@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK13_HUMAN: (2021-11-22 )
MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY
Atome Classification :
(509 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.-.---....-----.810.......820.......830.......840.....-..850.......860.-.....---.--870........880.......890.......900.......910.......920.......930.......940.......950----.-.-.-..------.-.--..960..---..-....970-----...---......980.......990......-.1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPSSSDTALGGGGG
L
S
W
A
E
K
K
L
E
E
R
R
K
R
R
RFLSPQQP
P
L
L
L
PLL
Q
P
Q
LLQPPPPPP
P
L
L
F
L
AAPG
T
A
A
A
A
A
A
A
AAASSSCFSPGP
P
L
E
V
K
R
L
ARGKRRAGG
R
Q
K
RRRGPRAG
Q
E
A
E
K
RRVFSLPQPQQDGGGGASSGGGV
T
P
L
V
E
YEDVSSQSEQ
G
L
L
LGGASAA
T
A
A
TAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSSSGR
S
K
E
R
H
R
E
H
R
RRDGQRGGS
E
A
S
KSRSRHSHS
G
E
E
R
A
E
V
A
KSGSSSSSGGRRKSASATSSSSSSRKDR
D
S
K
A
H
RSRTKSSKEP
P
S
AYKEP
P
K
A
Y
REDKTE
P
K
A
Y
R
R
RRSLSPLGGRDDSP
V
S
H
R
A
S
Q
S
L
R
SRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPY
S
P
V
L
R
RSGKSRSRSPYS
S
R
H
S
R
S
R
S
R
H
R
L
S
R
SRSRHSSISPS
T
L
T
L
K
S
S
L
A
A
E
LNKNK
K
A
R
A
A
E
A
A
R
A
A
E
A
A
K
A
A
E
A
T
K
A
A
E
A
A
A
K
AAKASNTSTPTKGNTETSASASQTN
H
V
K
D
V
K
K
I
K
I
E
HAPSPSSGGTLKNDKAKTKPP
L
Q
V
T
KVEN
N
L
I
V
DKAT
K
K
A
V
I
V
GKESKSAATKEESVSLKEKTKPLTPSIGAK
E
K
E
Q
H
V
A
L
VTSTLPPLPLPPMLPEDKE
A
D
SLRGNI
S
V
K
A
V
K
K
E
V
E
K
K
L
R
C
L
L
ADLPLPPELPGGDDLSKS
P
E
E
K
K
T
A
T
Q
L
HSKRRPKICGPRYGETKE
K
D
I
D
W
G
K
R
C
V
D
KF
D
I
I
G
I
IGEGTYG
Q
V
Y
KARDKDTG
E
M
V
A
L
K
K
V
RLDNEKEGFP
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
I
I
N
M
K
E
IVTD
K
E
D
ALDFKKDK
G
A
F
Y
L
V
F
E
YM
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H-----F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
KKNFLHRDIKCS
N
I
L
LNN-RG
Q
I
K
L
A
D
F
G
L
A
R
L
YS-SEESR---P--YT-N
K
V
I
T
L
W
YR
P
P
E
L
LLGEERYT
P
A
IDV
W
S
C
G
C
I
L
G
E
L
FTKKP
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
CGSPCPAV
W
P
D
V
IKLPYFNTM------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
K
L
-
R
EE---
F
V
-FI
P
A
A
-------
A
L
D
---
L
F
D
Y
M
L
ALDPSKRC
T
A
E
Q
A
L
Q
C
E
F
L
-RDVEPSKMPPPDL
P
L
W
Q
D
C
H
E
L
W
S
K
K
R
R
R
Q
K
QMGMTDD
V
S
T
IKAPR
K
D
LSLGLDDSRTNTPQGVL
P
S
S
Q
L
KSQGSSNVAPVKTGPGQHL
N
H
S
E
L
A
I
L
L
N
L
L
Q
S
KTSV
N
M
A
D
F
V
Q
V
L
N
I
K
VN
S
E
T
Q
Q
Q
L
N
KINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVE
T
D
A
A
Q
A
A
V
Q
S
A
F
A
V
L
L
T
Q
L
I
K
A
Q
QSKQKD
V
L
L
E
ERENGSGHE
A
S
L
Q
LRPPPEPSTPVSG
Q
D
D
L
I
Q
HQD
M
R
I
L
E
LTPEPDRPRILPPDQRPPEPPEPPPV
T
E
E
DLDYRTENQHVPTTSSSLTDPH
A
G
V
K
A
A
L
L
Q
L
L
A
QHQPQDDPKREGGIDYQAGD
T
Y
V
STSDYKDNFGSSSFSSAPYVSNDGLGSSSAPP
L
E
R
R
SFIGN
S
D
I
Q
S
LDNYSTASSHSGGPPQP
S
A
F
S
E
SFPSSVAGY
G
D
I
Y
LNAG
P
M
L
FSGDKD
H
R
F
EYSHG
P
I
A
V
L
ANSSDPSTGPESTHPLP
A
K
MHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY
21
Blastp_CBE
95.37
99%
-113
- C4 -
-
5EFQ
2
C:
[5-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
I
I
N
M
K
E
I
V
T
D
K
E
---------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
K
L
-
R
E
E
---
F
V
-
F
I
P
A
A
-------
A
L
D
---
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
-
R
D
V
E
P
S
K
M
P
P
P
D
L
P
L
W
Q
D
C
H
E
L
W
S
K
K
R
R
R
Q
K
Q
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
HHSearch
94.56
100%
-116
- C4 -
-
5EFQ
2
CDK13_HUMAN
A:
[3-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
I
I
N
M
K
E
I
V
T
D
K
E
---------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
K
L
-
R
E
E
---
F
V
-
F
I
P
A
A
-------
A
L
D
---
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
-
R
D
V
E
P
S
K
M
P
P
P
D
L
P
L
W
Q
D
C
H
E
L
W
S
K
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
94.48
91%
-113
- C4 -
-
4CXA
1
CDK12_HUMAN
A:
[6-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
--
L
D
F
K
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
E
E
-
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
R
R
R
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.33
99%
-116
- C4 -
-
5EFQ
2
CDK13_HUMAN
A:
[3-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
I
I
N
M
K
E
I
V
T
D
K
E
---------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
K
L
-
R
E
E
---
F
V
-
F
I
P
A
A
-------
A
L
D
---
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
-
R
D
V
E
P
S
K
M
P
P
P
D
L
P
L
W
Q
D
C
H
E
L
W
S
K
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.18
91%
-118
- C4 -
-
5ACB
1
CDK12_HUMAN
C:
[6-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
D
A
L
D
F
K
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
92.22
91%
-119
- C4 -
-
5ACB
1
D:
[6-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
----
F
K
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
----
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
91.53
90%
-119
- C4 -
-
6B3E
1
CDK12_HUMAN
A:
[2-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
----------
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.53
90%
-112
- C4 -
-
4NST
3
CDK12_HUMAN
A:
[6-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
D
--------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
HHSearch
91.33
91%
-113
- C4 -
-
4CXA
-
C:
[6-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
D
A
L
D
F
K
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
HHSearch
91.01
91%
-124
- C4 -
-
6B3E
3
C:
[3-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
----------
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
90.89
91%
-124
- C4 -
-
6B3E
3
C:
[3-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
----------
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
90.66
90%
-121
- C4 -
-
4NST
3
C:
[6-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
----------
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
-
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.34
90%
-118
- C4 -
-
4UN0
-
CDK12_HUMAN
C:
[719-1036]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
-------
K
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
----
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
87.06
90%
-135
- C4 -
-
6CKX
1
C:
[10-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
----------
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.93
90%
-135
- C4 -
-
6CKX
1
CDK12_HUMAN
A:
[10-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
----------
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-
S
---
G
L
V
H
-----
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
-
S
E
E
S
R
---
P
--
Y
T
-
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
------
K
-
P
-
K
-
K
Q
------
Y
-
R
--
R
R
L
-
R
E
E
---
F
S
-
F
I
P
S
A
-------
A
L
D
---
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-
K
D
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.22
48%
-77
- C4 -
-
6CYT
-
CDK9_HUMAN
A:
[18-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
K
--
A
S
----
C
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---
P
NR
Y
T
-
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
70.85
40%
-115
- C4 -
-
1V0P
1
CDC2H_PLAFK
A:
[1-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
K
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
K
K
----------
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
-
V
---
C
E
G
G
-----
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
-----------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
FTVYEP
L
-
P
-
W
-
E
S
------
F
-
L
--
K
G
L
-
D
E
-----------
S
-------
G
I
D
---
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.41
48%
-78
- C4 -
-
4OGR
1
CDK9_HUMAN
A:
[18-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---
P
NR
Y
T
-
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.40
48%
-87
- C4 -
-
4IMY
1
CDK9_HUMAN
A:
[18-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---
P
NR
Y
T
-
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.38
48%
-84
- C4 -
-
5L1Z
-
CDK9_HUMAN
A:
[16-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
----
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---
P
NR
Y
T
-
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.20
48%
-83
- C4 -
-
3MY1
3
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
K
---------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---
P
NR
Y
T
-
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.19
48%
-86
- C4 -
-
3LQ5
1
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
--
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
-------
P
NR
Y
T
-
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.96
48%
-90
- C4 -
-
3BLR
1
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
------------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
-------
P
NR
Y
T
-
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
---------------
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
66.75
44%
-49
- C4 -
-
3F5X
2
CDK2_HUMAN
C:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
66.71
44%
-48
- C4 -
-
2C5N
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
66.63
44%
-48
- C4 -
-
2WEV
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
66.59
44%
-43
- C4 -
-
4KD1
2
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
66.47
44%
-46
- C4 -
-
2C5O
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
66.40
44%
-58
- C4 -
-
2BKZ
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
66.36
44%
-47
- C4 -
-
2X1N
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
66.20
40%
-99
- C4 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
K
I
R
L
----------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
K
K
----------
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
-
V
---
C
E
G
G
-----
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
-
I
P
-
V
R
---
K
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
FTVYEP
L
-
P
-
W
-
E
S
------
F
-
L
--
K
G
L
-
D
E
-----------
S
-------
G
I
D
---
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
66.19
44%
-57
- C4 -
-
2BKZ
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
66.06
44%
-47
- C4 -
-
2UUE
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
65.99
44%
-47
- C4 -
-
2UUE
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
65.96
44%
-50
- C4 -
-
2CLX
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
65.91
44%
-48
- C4 -
-
2C5V
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
HHSearch
65.88
34%
-86
- C4 -
-
4IC7
1
MK07_HUMAN
A:
[53-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
----
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
-
S
---
S
-
Q
P
-----
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
-
T
S
P
A
E
HQY
F
--
M
T
-
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
------
Q
-
S
-
L
P
P
R
------
Q
-
P
--
V
P
W
-
E
T
V
---
Y
P
-
G
A
D
R
Q
-------
A
L
S
---
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
-
A
K
Y
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
65.86
44%
-47
- C4 -
-
1QMZ
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
65.81
44%
-53
- C4 -
-
1Y8Y
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
65.74
44%
-44
- C4 -
-
1FVV
1
CDK2_HUMAN
C:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
65.69
44%
-47
- C4 -
-
1FVV
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
65.66
44%
-49
- C4 -
-
2C6K
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
65.57
44%
-44
- C4 -
-
2C5N
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
65.49
44%
-46
- C4 -
-
1QMZ
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
HHSearch
65.47
34%
-89
- C4 -
-
4ZSG
6
MK07_HUMAN
A:
[5-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
----
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
-
S
---
S
-
Q
P
-----
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
-
T
S
P
A
E
HQY
F
--
M
T
-
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
------
Q
-
S
-
L
P
P
R
------
Q
-
P
--
V
P
W
-
E
T
V
---
Y
P
-
G
A
D
R
Q
-------
A
L
S
---
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
-
A
K
Y
H
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
65.43
44%
-44
- C4 -
-
2C5O
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
65.46
43%
-38
- C4 -
-
2C6T
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
65.44
40%
-102
- C4 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
K
I
R
L
--------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
K
K
----------
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
-
V
---
C
E
G
G
-----
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
-
I
P
-
V
R
---
K
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
FTVYEP
L
-
P
-
W
-
E
S
------
F
-
L
--
K
G
L
-
D
E
-----------
S
-------
G
I
D
---
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
65.43
44%
-45
- C4 -
-
2WEV
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
65.42
44%
-38
- C4 -
-
4FX3
2
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
65.33
44%
-50
- C4 -
-
2C6O
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
65.34
44%
-42
- C4 -
-
4FX3
1
CDK2_HUMAN
C:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
65.21
43%
-42
- C4 -
-
2UZE
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
65.33
44%
-48
- C4 -
-
2V0D
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
65.31
44%
-44
- C4 -
-
3QHR
6
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
65.21
44%
-45
- C4 -
-
4CFX
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
65.30
44%
-48
- C4 -
-
1FIN
1
CDK2_HUMAN
C:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
65.27
43%
-38
- C4 -
-
4EOI
1
CDK2_HUMAN
C:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
65.20
44%
-52
- C4 -
-
2C6I
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
65.20
44%
-47
- C4 -
-
2XMY
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
65.17
44%
-45
- C4 -
-
1YKR
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
65.21
44%
-43
- C4 -
-
1FIN
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
65.20
48%
-70
- C4 -
-
3BLQ
1
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
------------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
----------NR
Y
T
-
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
----------------
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
65.19
44%
-48
- C4 -
-
4FKU
3
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
65.17
44%
-46
- C4 -
-
2X1N
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
65.15
44%
-44
- C4 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
65.01
44%
-46
- C4 -
-
4BCN
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
65.10
44%
-43
- C4 -
-
3QHR
2
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
65.09
44%
-52
- C4 -
-
4FKL
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
65.08
44%
-50
- C4 -
-
2R3F
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
65.05
44%
-43
- C4 -
-
4CFN
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
65.03
43%
-42
- C4 -
-
2UZL
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
65.01
44%
-49
- C4 -
-
2C68
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
65.00
44%
-45
- C4 -
-
3F5X
2
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
64.98
44%
-53
- C4 -
-
2UZO
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
64.97
43%
-43
- C4 -
-
2UZB
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
64.86
44%
-46
- C4 -
-
5CYI
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
64.81
43%
-43
- C4 -
-
1JST
1
CDK2_HUMAN
C:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
64.92
44%
-44
- C4 -
-
4EOO
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
64.89
44%
-40
- C4 -
-
2EXM
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
64.78
44%
-49
- C4 -
-
1H1S
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
64.86
44%
-48
- C4 -
-
1OI9
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
64.84
44%
-50
- C4 -
-
2C6M
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
64.82
44%
-43
- C4 -
-
4EOL
1
CDK2_HUMAN
C:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
64.81
44%
-47
- C4 -
-
4BCM
1
CDK2_HUMAN
C:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
64.80
44%
-47
- C4 -
-
2C5V
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
64.66
43%
-40
- C4 -
-
2UZD
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
64.66
43%
-38
- C4 -
-
2UZE
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
64.78
44%
-52
- C4 -
-
2C5Y
1
CDK2_HUMAN
A:
[1-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
64.74
43%
-41
- C4 -
-
4II5
2
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
64.73
43%
-40
- C4 -
-
4II5
3
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
64.72
44%
-54
- C4 -
-
2WPA
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
64.58
44%
-50
- C4 -
-
1P5E
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
64.69
44%
-46
- C4 -
-
1H1R
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
64.60
44%
-50
- C4 -
-
2R3O
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
64.66
44%
-43
- C4 -
-
1H1S
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
64.64
44%
-54
- C4 -
-
3EOC
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
64.63
48%
-84
- C4 -
-
4BCG
2
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---
P
--
N
R
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
64.50
44%
-46
- C4 -
-
4EOK
1
CDK2_HUMAN
C:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
64.61
44%
-51
- C4 -
-
1B38
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
64.60
44%
-44
- C4 -
-
3TIY
13
CDK2_HUMAN
A:
[2-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
64.59
44%
-46
- C4 -
-
4CFV
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
64.58
44%
-51
- C4 -
-
2WIH
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
64.57
43%
-37
- C4 -
-
2UZL
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
64.56
44%
-48
- C4 -
-
1H1Q
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
64.43
43%
-35
- C4 -
-
1JST
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
64.53
44%
-50
- C4 -
-
2C4G
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
64.52
44%
-47
- C4 -
-
2C5X
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
64.50
44%
-49
- C4 -
-
2BPM
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
64.50
44%
-52
- C4 -
-
2WXV
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
64.43
44%
-48
- C4 -
-
2C5X
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
64.46
44%
-46
- C4 -
-
2C6L
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
64.43
44%
-46
- C4 -
-
4EK5
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
64.43
44%
-48
- C4 -
-
4FKI
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
64.43
44%
-53
- C4 -
-
2WIH
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
64.41
44%
-48
- C4 -
-
3UNJ
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
64.33
44%
-49
- C4 -
-
6GUC
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
64.39
44%
-48
- C4 -
-
1H1Q
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
64.29
44%
-45
- C4 -
-
5CYI
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
64.38
44%
-50
- C4 -
-
1VYW
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
64.34
44%
-51
- C4 -
-
4LYN
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
64.35
44%
-47
- C4 -
-
2IW6
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
64.34
44%
-50
- C4 -
-
2C4G
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
64.33
44%
-50
- C4 -
-
2IW9
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
64.32
44%
-51
- C4 -
-
2WPA
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
64.30
44%
-46
- C4 -
-
5L2W
2
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
64.29
44%
-51
- C4 -
-
2R3R
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
64.28
44%
-52
- C4 -
-
3DDP
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
64.16
44%
-41
- C4 -
-
4EON
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
64.27
43%
-39
- C4 -
-
4EOI
2
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
64.20
44%
-46
- C4 -
-
1PXJ
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
64.25
44%
-49
- C4 -
-
2C69
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
HHSearch
64.11
34%
-83
- C4 -
-
5BYZ
7
MK07_HUMAN
A:
[5-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
----
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
-
S
---
S
-
Q
P
-----
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
-
T
S
P
A
E
HQY
F
--
M
T
-
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
------
Q
-
S
-
L
P
P
R
------
Q
-
P
--
V
P
W
-
E
T
V
---
Y
P
-
G
A
D
R
Q
-------
A
L
S
---
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
-
A
K
Y
H
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
64.11
44%
-41
- C4 -
-
4I3Z
3
CDK2_HUMAN
C:
[1-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
64.23
44%
-46
- C4 -
-
4EOJ
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
64.22
44%
-55
- C4 -
-
3R83
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
64.21
44%
-49
- C4 -
-
2I40
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
64.20
44%
-57
- C4 -
-
3QX2
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
64.14
44%
-49
- C4 -
-
1PXI
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
64.08
44%
-53
- C4 -
-
4EOM
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
64.11
44%
-48
- C4 -
-
2R3P
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
64.04
44%
-46
- C4 -
-
1E9H
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
64.17
44%
-46
- C4 -
-
3TIZ
9
CDK2_HUMAN
A:
[2-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
64.11
44%
-45
- C4 -
-
1HCK
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
64.16
44%
-46
- C4 -
-
1E1X
2
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
64.15
44%
-40
- C4 -
-
4I3Z
4
CDK2_HUMAN
A:
[1-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
64.14
44%
-46
- C4 -
-
2B54
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
64.07
44%
-53
- C4 -
-
1B39
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
64.13
44%
-46
- C4 -
-
1VYW
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
64.12
43%
-40
- C4 -
-
2UZB
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
64.04
44%
-47
- C4 -
-
1W8C
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
64.07
44%
-46
- C4 -
-
2B53
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
64.11
44%
-47
- C4 -
-
3EJ1
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
63.98
44%
-54
- C4 -
-
2CCI
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
64.04
44%
-50
- C4 -
-
1PXL
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
64.08
44%
-53
- C4 -
-
5IEY
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
64.07
44%
-44
- C4 -
-
2XNB
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
64.04
44%
-48
- C4 -
-
3EID
1
CDK2_HUMAN
A:
[1-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
64.04
44%
-54
- C4 -
-
3QZH
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
64.02
44%
-47
- C4 -
-
4CFW
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
63.86
43%
-43
- C4 -
-
2UZD
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
63.76
44%
-44
- C4 -
-
3DDP
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
63.98
44%
-52
- C4 -
-
4FKQ
2
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
63.97
44%
-50
- C4 -
-
4EK4
1
CDK2_HUMAN
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
63.96
44%
-50
- C4 -
-
2VTO
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
63.83
44%
-43
- C4 -
-
4EON
1
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
63.92
44%
-49
- C4 -
-
3ULI
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
63.94
44%
-43
- C4 -
-
4BCP
1
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
63.92
44%
-59
- C4 -
-
3RM7
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
63.78
44%
-41
- C4 -
-
3QHW
3
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
63.79
44%
-49
- C4 -
-
2CCI
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
63.85
44%
-50
- C4 -
-
1Y91
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
63.89
44%
-44
- C4 -
-
2IW8
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
63.88
44%
-52
- C4 -
-
6GUB
1
?
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-----------------------
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
63.87
44%
-41
* C4 *
-
4EOP
1
CDK2_HUMAN
C:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
63.86
44%
-48
- C4 -
-
1H1R
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
63.85
44%
-43
- C4 -
-
5ANE
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
63.73
44%
-44
- C4 -
-
1GY3
2
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
63.83
44%
-54
- C4 -
-
1WCC
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
63.71
44%
-45
- C4 -
-
1P5E
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
63.82
44%
-45
- C4 -
-
3NS9
1
CDK2_HUMAN
A:
[3-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
63.77
44%
-46
- C4 -
-
1PXO
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
63.71
44%
-46
- C4 -
-
4CFW
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
63.71
44%
-46
- C4 -
-
5NEV
1
?
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
63.80
44%
-48
- C4 -
-
5NEV
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
63.79
44%
-55
- C4 -
-
3WBL
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
63.78
44%
-48
- C4 -
-
4BCK
2
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
63.77
44%
-53
- C4 -
-
5IEX
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
63.76
44%
-46
- C4 -
-
1PXP
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
63.73
44%
-50
- C4 -
-
3IGG
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
63.64
44%
-49
- C4 -
-
5LMK
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
63.61
44%
-43
- C4 -
-
1PKD
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
63.63
44%
-44
- C4 -
-
4BCO
1
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
63.73
44%
-59
- C4 -
-
3R7E
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
63.72
44%
-47
- C4 -
-
3DDQ
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
63.71
44%
-48
- C4 -
-
2R3I
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
63.60
44%
-51
- C4 -
-
4BCK
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
63.70
43%
-38
- C4 -
-
2C6T
1
CDK2_HUMAN
C:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
63.69
44%
-45
- C4 -
-
6GUF
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
63.68
44%
-43
- C4 -
-
1PXN
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
63.57
44%
-51
- C4 -
-
3TNW
1
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
63.67
44%
-51
- C4 -
-
2WXV
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
63.66
43%
-46
- C4 -
-
4RJ3
1
CDK2_HUMAN
A:
[1-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
L
I
R
L
D
T
-------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
63.54
44%
-41
- C4 -
-
1H1P
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
63.63
44%
-47
- C4 -
-
3EJ1
1
CDK2_HUMAN
C:
[1-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
63.62
44%
-45
- C4 -
-
2G9X
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
63.49
44%
-48
- C4 -
-
4EOK
1
CDK2_HUMAN
A:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
63.51
44%
-48
- C4 -
-
3BHT
1
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
63.61
44%
-47
- C4 -
-
1PF8
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
63.60
44%
-54
- C4 -
-
6Q4C
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
63.59
44%
-58
- C4 -
-
3RAI
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
63.51
44%
-48
- C4 -
-
2IW6
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
63.58
44%
-47
- C4 -
-
2BPM
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
63.57
44%
-55
- C4 -
-
3R1Y
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
63.51
44%
-46
- C4 -
-
1H0V
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
63.55
44%
-44
- C4 -
-
3UNK
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
63.46
44%
-46
- C4 -
-
6GUE
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
N
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
63.54
44%
-46
- C4 -
-
4CFU
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
63.53
44%
-47
- C4 -
-
3BHV
2
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
63.51
44%
-48
- C4 -
-
3FZ1
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
63.50
44%
-47
- C4 -
-
4EOS
1
CDK2_HUMAN
C:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
63.49
44%
-47
- C4 -
-
2VTL
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
63.48
44%
-54
- C4 -
-
2WIP
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
63.42
44%
-47
- C4 -
-
1JSV
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
63.47
44%
-47
- C4 -
-
1OI9
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
63.46
44%
-57
- C4 -
-
3PY0
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
63.34
44%
-42
- C4 -
-
1GY3
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
63.28
44%
-46
- C4 -
-
1OIY
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
63.44
44%
-43
- C4 -
-
3LFN
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
63.41
44%
-43
- C4 -
-
2VTR
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
63.43
44%
-42
- C4 -
-
2CCH
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
63.36
44%
-53
- C4 -
-
6Q4F
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
63.42
44%
-52
- C4 -
-
5IEV
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
63.33
44%
-51
- C4 -
-
6GUC
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
63.36
44%
-44
- C4 -
-
2A0C
1
CDK2_HUMAN
X:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
63.30
44%
-48
- C4 -
-
1OIU
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
63.32
44%
-49
- C4 -
-
1H0W
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
63.37
44%
-57
- C4 -
-
1W0X
1
CDK2_HUMAN
C:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
63.33
44%
-45
- C4 -
-
2R3H
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
63.36
44%
-56
- C4 -
-
3R73
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
63.35
44%
-41
- C4 -
-
3QHW
2
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
63.34
44%
-48
- C4 -
-
4EOS
1
CDK2_HUMAN
A:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
63.33
44%
-44
- C4 -
-
3LFS
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
63.32
44%
-51
- C4 -
-
6Q4B
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
63.23
44%
-49
- C4 -
-
4EOO
1
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
63.31
44%
-44
- C4 -
-
2VTM
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
63.30
44%
-49
- C4 -
-
2I40
1
CDK2_HUMAN
A:
[1-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
63.29
44%
-46
- C4 -
-
4FKG
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
63.19
44%
-40
- C4 -
-
1H1P
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
63.28
44%
-53
- C4 -
-
3R1S
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
63.27
44%
-49
- C4 -
-
4BCQ
1
CDK2_HUMAN
C:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
63.26
44%
-44
- C4 -
-
4EOL
1
CDK2_HUMAN
A:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
----
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
63.25
44%
-56
- C4 -
-
2R64
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
63.23
44%
-49
- C4 -
-
3EOC
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
63.21
44%
-43
- C4 -
-
4BCN
1
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
63.19
44%
-54
- C4 -
-
3QZI
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
63.17
44%
-45
- C4 -
-
4FKO
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
63.17
44%
-54
- C4 -
-
3RPO
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
63.16
44%
-52
- C4 -
-
3PXY
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
63.12
44%
-45
- C4 -
-
3LFQ
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
63.04
44%
-47
- C4 -
-
4EOP
1
CDK2_HUMAN
A:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
63.01
44%
-47
- C4 -
-
6GUB
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
63.09
44%
-53
- C4 -
-
3R8U
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
63.08
44%
-57
- C4 -
-
1CKP
2
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
63.07
44%
-57
- C4 -
-
2WIP
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
63.06
44%
-47
- C4 -
-
3BHU
1
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
63.05
44%
-53
- C4 -
-
3QQF
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
63.04
44%
-50
- C4 -
-
3QTQ
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
62.96
44%
-42
- C4 -
-
1OIY
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
63.04
44%
-51
- C4 -
-
3RK7
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
63.01
44%
-51
- C4 -
-
4EK8
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
62.93
44%
-43
- C4 -
-
1OGU
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
63.01
44%
-52
- C4 -
-
3QTZ
3
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
62.94
44%
-46
- C4 -
-
2R3G
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
62.99
44%
-48
- C4 -
-
3QU0
5
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
62.99
48%
-80
- C4 -
-
3MIA
1
CDK9_HUMAN
A:
[16-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
---
P
--
N
R
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
62.98
44%
-51
- C4 -
-
5OO3
1
CDK2_HUMAN
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
62.91
44%
-46
- C4 -
-
2R3Q
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
62.96
44%
-53
- C4 -
-
4FKW
2
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
62.94
44%
-52
- C4 -
-
2UZN
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
62.97
44%
-51
- C4 -
-
3QQK
6
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
62.91
44%
-56
- C4 -
-
1KE9
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
62.96
44%
-50
- C4 -
-
3R9H
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
62.95
44%
-42
- C4 -
-
3TNW
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
62.94
44%
-54
- C4 -
-
3R71
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
62.93
44%
-47
- C4 -
-
3R9D
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
62.92
44%
-52
- C4 -
-
3R28
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
62.91
44%
-51
- C4 -
-
2VTS
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
62.90
44%
-50
- C4 -
-
3QXO
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
62.89
44%
-53
- C4 -
-
4FKP
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
62.88
44%
-46
- C4 -
-
3QQL
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
62.86
44%
-47
- C4 -
-
4BCM
1
CDK2_HUMAN
A:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
62.83
44%
-40
- C4 -
-
4CFM
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
HHSearch
62.81
34%
-86
- C4 -
-
4B99
1
MK07_HUMAN
A:
[52-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
----
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
-
S
----
S
Q
P
-----
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
-------QY-
F
--
M
T
-
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
-----
R
V
R
A
Y
I
------
Q
-
S
-
L
P
P
R
------
Q
-
P
--
V
P
W
-
E
T
V
---
Y
P
-
G
A
D
R
Q
-------
A
L
S
---
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
-
A
K
Y
H
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
62.80
44%
-45
- C4 -
-
1PKD
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
62.79
44%
-45
- C4 -
-
3QRU
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
62.76
44%
-55
- C4 -
-
1KE6
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
62.73
44%
-50
- C4 -
-
3R7V
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
62.61
44%
-43
- C4 -
-
3DOG
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
62.71
44%
-49
- C4 -
-
2VTP
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
62.61
44%
-46
- C4 -
-
4CFX
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
62.59
44%
-42
- C4 -
-
2CCH
3
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
62.65
44%
-47
- C4 -
-
1PXM
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
62.69
44%
-48
- C4 -
-
4EOR
1
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
62.63
44%
-47
- C4 -
-
1PXK
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
62.61
44%
-49
- C4 -
-
5OSM
1
CDK2_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
62.66
44%
-46
- C4 -
-
4FKV
2
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
62.67
44%
-51
- C4 -
-
3QXP
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
62.67
44%
-53
- C4 -
-
3ROY
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
62.66
44%
-52
- C4 -
-
3QWK
5
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
62.66
44%
-54
- C4 -
-
3QZG
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
62.62
44%
-47
- C4 -
-
2A4L
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
62.66
44%
-55
- C4 -
-
3R6X
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
62.65
44%
-53
- C4 -
-
6Q4K
3
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
62.64
44%
-52
- C4 -
-
3R7Y
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
62.63
44%
-52
- C4 -
-
6Q4D
6
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
62.61
44%
-44
- C4 -
-
5JQ5
1
CDK2_HUMAN
A:
[3-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
62.61
44%
-49
- C4 -
-
3RNI
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
62.59
44%
-46
- C4 -
-
5K4J
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
62.56
44%
-52
- C4 -
-
3R8V
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
62.54
44%
-49
- C4 -
-
4FKR
2
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
62.54
44%
-53
- C4 -
-
6Q4H
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
62.53
44%
-45
- C4 -
-
1H07
1
CDK2_HUMAN
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-----
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
62.39
40%
-116
- C4 -
-
1V0P
1
CDC2H_PLAFK
B:
[2-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
-----------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
-------------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
-
V
---
C
E
G
G
-----
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
---------------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
FTVYEP
L
-
P
-
W
-
E
S
------
F
-
L
--
K
G
L
-
D
E
-----------
S
-------
G
I
D
---
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
62.46
44%
-45
- C4 -
-
3PJ8
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
62.52
44%
-52
- C4 -
-
3RJC
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
62.45
44%
-47
- C4 -
-
1H08
2
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
62.50
44%
-43
- C4 -
-
6GVA
3
CDK2_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
62.42
44%
-55
- C4 -
-
2VTH
2
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
62.48
44%
-54
- C4 -
-
3QZF
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
62.47
44%
-48
- C4 -
-
4EOQ
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
62.46
44%
-48
- C4 -
-
3IG7
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
62.45
44%
-43
- C4 -
-
4GCJ
5
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
62.44
44%
-56
- C4 -
-
4EZ3
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
62.42
44%
-41
- C4 -
-
3PXZ
3
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
62.39
44%
-41
- C4 -
-
4CFN
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
62.38
48%
-87
- C4 -
-
4BCJ
1
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
K
---------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
-------
P
--
N
R
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
62.37
44%
-50
- C4 -
-
3R8P
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
62.32
44%
-45
- C4 -
-
2W1H
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
62.23
44%
-44
- C4 -
-
6GUF
1
CDK2_HUMAN
A:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
62.29
44%
-40
- C4 -
-
1E9H
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
62.28
44%
-55
- C4 -
-
3S2P
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
62.21
44%
-47
- C4 -
-
1DI8
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
62.26
44%
-44
- C4 -
-
3MY5
3
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
62.17
44%
-53
- C4 -
-
4BCQ
1
CDK2_HUMAN
A:
[4-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
62.20
44%
-52
- C4 -
-
1KE7
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
62.23
44%
-50
- C4 -
-
3QQG
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
62.17
44%
-52
- C4 -
-
1KE5
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
62.22
44%
-37
- C4 -
-
3PY1
4
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
62.21
44%
-48
- C4 -
-
3RK9
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
62.20
48%
-86
- C4 -
-
4BCH
2
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
K
--
A
-------
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L--------
P
--
N
R
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
62.17
44%
-56
- C4 -
-
3R8Z
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
----------
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
62.16
44%
-53
- C4 -
-
2VTA
3
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
62.13
44%
-52
- C4 -
-
6Q4A
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
62.12
44%
-51
- C4 -
-
3QX4
3
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
62.11
44%
-52
- C4 -
-
3QQH
4
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
62.09
44%
-52
- C4 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
62.07
44%
-50
- C4 -
-
3SW4
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
62.05
44%
-49
- C4 -
-
3RK5
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
61.95
44%
-50
- C4 -
-
6GUE
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
-----
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
--------------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
62.02
44%
-53
- C4 -
-
2W17
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
62.00
44%
-51
- C4 -
-
4FKT
1
CDK2_HUMAN
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
62.00
44%
-55
- C4 -
-
6Q4J
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
61.98
44%
-51
- C4 -
-
6Q4I
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
L
-----
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
61.95
44%
-41
- C4 -
-
5A14
2
CDK2_HUMAN
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
61.96
44%
-56
- C4 -
-
2VTI
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
61.95
44%
-42
- C4 -
-
3PXQ
4
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
61.94
44%
-49
- C4 -
-
1FVT
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
61.92
44%
-49
- C4 -
-
1KE8
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
61.88
44%
-45
- C4 -
-
2W06
2
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
61.86
44%
-39
- C4 -
-
3PXF
7
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
61.82
44%
-53
- C4 -
-
3QQJ
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
61.81
44%
-51
- C4 -
-
3QL8
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
61.78
48%
-84
- C4 -
-
4BCI
1
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
-----------
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
-------
P
--
N
R
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
61.77
44%
-49
- C4 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
61.76
44%
-56
- C4 -
-
6Q4G
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
61.69
44%
-53
- C4 -
-
1GII
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
61.69
44%
-49
- C4 -
-
4FKJ
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
61.69
44%
-49
- C4 -
-
5ANI
1
CDK2_HUMAN
A:
[2-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
61.66
44%
-55
- C4 -
-
5ANK
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
61.65
48%
-84
- C4 -
-
4BCF
1
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
K
A
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L--------
P
--
N
R
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
61.63
44%
-49
- C4 -
-
3RPV
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
61.63
44%
-52
- C4 -
-
3S00
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
61.62
44%
-55
- C4 -
-
6Q4E
3
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
61.52
44%
-50
- C4 -
-
3QWJ
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
61.51
44%
-56
- C4 -
-
3S0O
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
61.49
44%
-49
- C4 -
-
2J9M
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
61.47
44%
-59
- C4 -
-
5AND
1
CDK2_HUMAN
A:
[2-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
61.48
44%
-43
- C4 -
-
2VU3
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
----
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
61.47
44%
-48
- C4 -
-
3RM6
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
61.46
44%
-53
- C4 -
-
4FKS
1
CDK2_HUMAN
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
61.45
44%
-37
- C4 -
-
4EZ7
7
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
61.42
44%
-52
- C4 -
-
4BGH
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
61.39
44%
-47
- C4 -
-
2R3L
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
61.38
44%
-57
- C4 -
-
6Q3B
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
61.37
44%
-50
- C4 -
-
3QTX
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
61.34
44%
-50
- C4 -
-
3QTW
6
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
61.26
44%
-48
- C4 -
-
3QTU
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
61.24
44%
-47
- C4 -
-
2R3M
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
61.22
44%
-54
- C4 -
-
3QTS
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
61.22
44%
-50
- C4 -
-
3R8L
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
61.20
44%
-46
- C4 -
-
2B52
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
61.09
44%
-61
- C4 -
-
5OO1
1
CDK2_HUMAN
A:
[9-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
-------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
61.09
44%
-47
- C4 -
-
1VYZ
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
61.09
44%
-48
- C4 -
-
2BHH
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
61.12
44%
-51
- C4 -
-
3RKB
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
61.11
44%
-63
- C4 -
-
4EOJ
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
-----------------------------------------
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
61.09
44%
-43
- C4 -
-
3QRT
3
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
60.89
44%
-55
- C4 -
-
5MHQ
1
?
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
-
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
60.89
44%
-49
- C4 -
-
2R3K
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
60.94
44%
-44
- C4 -
-
4EK6
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
60.91
44%
-51
- C4 -
-
2VV9
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
60.92
44%
-40
- C4 -
-
3LE6
1
CDK2_HUMAN
A:
[1-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
60.91
44%
-48
- C4 -
-
3SW7
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
60.90
44%
-48
- C4 -
-
1V1K
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
60.89
44%
-45
- C4 -
-
1H00
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
60.74
44%
-43
- C4 -
-
4ACM
3
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
60.76
44%
-56
- C4 -
-
3RAH
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
60.74
48%
-79
- C4 -
-
3TN8
2
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
-----------
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L----
Q
---
P
--
N
R
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
K
L
------
E
-
L
-
V
-
K
G
------
Q
-
K
--
R
K
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
60.70
44%
-44
- C4 -
-
2B55
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
60.68
44%
-55
- C4 -
-
6GUK
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
60.63
44%
-46
- C4 -
-
4BZD
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
60.62
44%
-50
- C4 -
-
3SQQ
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
60.60
44%
-49
- C4 -
-
4D1X
1
CDK2_HUMAN
A:
[3-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
60.55
44%
-43
- C4 -
-
2FVD
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
--
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
60.53
43%
-37
- C4 -
-
1FQ1
1
CDK2_HUMAN
B:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
60.44
44%
-50
- C4 -
-
1DM2
5
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
60.50
44%
-54
- C4 -
-
3RPR
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
60.44
44%
-58
- C4 -
-
3R7U
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
60.37
44%
-49
- C4 -
-
2R3J
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
60.32
44%
-57
- C4 -
-
6Q48
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
60.30
44%
-56
- C4 -
-
3R7I
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
60.23
44%
-58
- C4 -
-
2G9X
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
------------------------------------------------
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
60.21
44%
-48
- C4 -
-
2BTS
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
60.17
44%
-52
- C4 -
-
1URW
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
59.94
44%
-41
- C4 -
-
4NJ3
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
59.90
44%
-40
- C4 -
-
5FP6
2
CDK2_HUMAN
A:
[1-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
59.78
44%
-47
- C4 -
-
2W05
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
59.77
44%
-51
- C4 -
-
3R9N
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
59.73
44%
-47
- C4 -
-
1GIH
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
59.59
44%
-51
- C4 -
-
3R8M
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
59.57
44%
-46
- C4 -
-
2VTN
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
59.53
44%
-52
- C4 -
-
1OIT
1
CDK2_HUMAN
A:
[3-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
59.47
44%
-64
- C4 -
-
4EOR
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
------------------------------------------------
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
59.44
44%
-52
- C4 -
-
3QTR
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
59.41
44%
-44
- C4 -
-
2VTJ
2
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
59.39
44%
-62
- C4 -
-
2IW9
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------------------
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
59.28
41%
-44
- C4 -
-
6GU6
1
CDK1_HUMAN
A:
[15-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
--
Q
D
S
--------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-
S
IPP
G
-
Q
Y
-----
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
-
I
P
-
I
--------
T
-
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
N
T
------
F
-
P
-
K
-
W
K
PGSLAS
H
-
V
--
K
N
L
-
D
E
N
------------------
G
L
D
---
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
-
N
D
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
59.26
44%
-54
- C4 -
-
3RPY
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
59.25
44%
-44
- C4 -
-
2VTQ
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
59.23
44%
-62
- C4 -
-
4EOQ
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
59.21
44%
-52
- C4 -
-
3EZV
1
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
HHSearch
59.20
37%
-93
- C4 -
-
4BGQ
3
CDKL5_HUMAN
A:
[10-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
----------
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
-
E
---
M
P
N
G
-----
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
-
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
-
E
-----------------
T
R
W
Y
R
S
P
E
L
L
L
G
A
-
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
G
L
------
R
F
P
-
A
-
V
N
------
H
P
Q
--
S
L
E
-
R
R
Y
---
L
G
-
I
L
N
S
V
-------
L
L
D
---
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
-
Q
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
59.15
44%
-44
- C4 -
-
2BTR
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
59.09
44%
-44
- C4 -
-
2DUV
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------------
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
59.04
44%
-62
- C4 -
-
1OGU
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------------
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
58.92
44%
-64
- C4 -
-
3BHT
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------------
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
58.96
44%
-43
- C4 -
-
2VTT
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
58.92
44%
-62
- C4 -
-
3BHU
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------------
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
58.88
44%
-59
- C4 -
-
4BCO
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------------
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
58.84
41%
-37
- C4 -
-
6GU4
1
CDK1_HUMAN
A:
[15-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
--
Q
D
S
--------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-
S
IPP
G
-
Q
Y
-----
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
-
I
P
-
I
R
---
V
--
Y
T
-
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
N
T
------
F
-
P
-
K
-
W
K
PGSLAS
H
-
V
--
K
N
L
-
D
E
N
------------------
G
L
D
---
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
-
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
58.77
44%
-58
- C4 -
-
6INL
1
?
A:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
58.76
44%
-41
- C4 -
-
1AQ1
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
58.75
44%
-52
- C4 -
-
3S1H
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
58.61
41%
-34
- C4 -
-
4Y72
1
CDK1_HUMAN
A:
[15-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
--
Q
D
S
--------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-
S
IPP
G
-
Q
Y
-----
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
-
I
P
-
I
R
---
V
--
Y
T
-
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
N
T
------
F
-
P
-
K
-
W
K
PGSLAS
H
-
V
--
K
N
L
-
D
E
N
------------------
G
L
D
---
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
-
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
58.61
41%
-34
- C4 -
-
5HQ0
1
CDK1_HUMAN
A:
[15-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
--
Q
D
S
--------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-
S
IPP
G
-
Q
Y
-----
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
-
I
P
-
I
R
---
V
--
Y
T
-
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
N
T
------
F
-
P
-
K
-
W
K
PGSLAS
H
-
V
--
K
N
L
-
D
E
N
------------------
G
L
D
---
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
-
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
58.74
44%
-57
- C4 -
-
3BHV
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------------
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
58.66
44%
-54
- C4 -
-
3RAK
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
58.55
44%
-55
- C4 -
-
4CFM
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------------------------
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
58.63
44%
-50
- C4 -
-
3RMF
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
58.62
44%
-50
- C4 -
-
3RZB
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
58.61
44%
-62
- C4 -
-
3MY5
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
---------------------------------------------------------
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
58.59
44%
-51
- C4 -
-
3R9O
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
58.56
44%
-47
- C4 -
-
6GUH
3
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
58.55
44%
-48
- C4 -
-
1R78
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
58.54
44%
-60
- C4 -
-
4EOM
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
57.88
41%
-37
- C4 -
-
4YC3
1
CDK1_HUMAN
A:
[15-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
--
Q
D
S
--------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-
S
IPP
G
-
Q
Y
-----
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
-
I
P
-
I
R
---
V
--
Y
T
----
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
N
T
------
F
-
P
-
K
-
W
K
PGSLAS
H
-
V
--
K
N
L
-
D
E
N
------------------
G
L
D
---
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
-
N
D
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
57.84
44%
-60
- C4 -
-
5LMK
1
?
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
57.83
44%
-39
- C4 -
-
1GIJ
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
57.81
41%
-32
- C4 -
-
6GU3
1
CDK1_HUMAN
A:
[15-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
--
Q
D
S
--------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-
S
IPP
G
-
Q
Y
-----
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
-
I
P
-
I
R
---
V
--
Y
T
-
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
N
T
------
F
-
P
-
K
-
W
K
PGSLAS
H
-
V
--
K
N
L
-
D
E
N
------------------
G
L
D
---
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
-
N
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
57.79
44%
-60
- C4 -
-
4CFV
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------------------------------
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
57.72
44%
-59
- C4 -
-
3DOG
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------------------------------
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
57.64
44%
-59
- C4 -
-
4CFU
1
CDK2_HUMAN
C:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------------
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
57.54
44%
-53
- C4 -
-
3RAL
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
57.51
44%
-46
- C4 -
-
1G5S
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
57.47
44%
-59
- C4 -
-
4BCP
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------------
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
57.45
44%
-55
- C4 -
-
3DDQ
1
CDK2_HUMAN
C:
[2-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
57.44
44%
-59
- C4 -
-
2IW8
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
57.39
44%
-46
- C4 -
-
3EZR
2
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
--------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
57.36
41%
-34
- C4 -
-
6GU2
1
CDK1_HUMAN
A:
[15-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
--
Q
D
S
--------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-
S
IPP
G
-
Q
Y
-----
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
-
I
P
-
I
R
---
V
--
Y
T
----
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
N
T
------
F
-
P
-
K
-
W
K
PGSLAS
H
-
V
--
K
N
L
-
D
E
N
------------------
G
L
D
---
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
-
N
D
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
56.87
44%
-45
- C4 -
-
5D1J
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
--------------
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
-------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
56.86
44%
-51
- C4 -
-
1OIQ
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
---
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
56.73
44%
-53
- C4 -
-
1PYE
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
56.70
44%
-43
- C4 -
-
1P2A
1
CDK2_HUMAN
A:
[1-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
56.42
44%
-57
- C4 -
-
1OIU
1
CDK2_HUMAN
C:
[5-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
-
P
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
55.72
42%
-25
- C4 -
-
4KRC
1
PHO85_YEAST
A:
[13-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
K
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
S
E
-
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
-
H
T
E
N
K
L
T
---------
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
-
S
---
R
---TPRG-
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
-
I
P
V
N
----
T
--
F
S
-
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
----------
P
-
N
-
I
Q
------
Q
-
R
PP
R
D
L
-
R
Q
-----
V
-
L
Q
P
H
T
KEPLDGN
L
M
D
---
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
55.67
48%
-76
- C4 -
-
3TNH
1
CDK9_HUMAN
A:
[17-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
------------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
-
N
---
V
L
V
K
-----
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
------------
N
R
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
---------------------------------
V
-
K
D
R
LKA
Y
V
-
R
D
P
-
Y
-------
A
L
D
---
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
P
M
P
S
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
55.61
44%
-43
- C4 -
-
5FP5
3
CDK2_HUMAN
A:
[1-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
---
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
HHSearch
55.54
31%
-46
- C4 -
-
1J1B
1
GSK3B_HUMAN
A:
[53-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
----
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
-
H
YSR
A
K
Q
T
-----
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
-----
P
--
N
V
-
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
------
K
-
F
P
Q
-
I
K
------
A
-
H
--
P
W
T
-
K
V
F
---
R
P
-
R
T
P
P
E
-------
A
I
A
---
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
-
D
E
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
55.33
44%
-52
- C4 -
-
2R3N
1
CDK2_HUMAN
A:
[2-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
55.33
44%
-43
- C4 -
-
5ANG
1
CDK2_HUMAN
A:
[2-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
---
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
53.77
44%
-39
- C4 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
-------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
HHSearch
53.50
31%
-45
- C4 -
-
4NM3
5
GSK3B_HUMAN
A:
[53-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
-
H
YSR
A
K
Q
T
-----
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
-----
P
--
N
V
-
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
E
F
------
K
-
F
-
P
-
Q
I
------
K
-
A
--
H
P
W
T
K
V
F
---
R
P
-
R
T
P
P
E
-------
A
I
A
---
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
-
D
E
L
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
52.46
42%
-27
- C4 -
-
2PMI
2
PHO85_YEAST
A:
[19-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
V
Y
K
G
L
N
K
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
S
E
-
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
-
H
T
E
N
K
L
T
---------
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
-
S
---
R
T
V
G
NTPRG
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
-
I
P
V
N
----
T
--
F
S
-
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
----------
P
-
N
-
I
Q
------
Q
-
R
PP
R
D
L
-
R
Q
-----
V
-
L
Q
P
H
T
KEPLDGN
L
M
D
---
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
44.44
43%
-31
- C4 -
-
1OIR
1
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
-
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
37.26
43%
-34
- C4 -
-
1H01
3
CDK2_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
-
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
----------
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
-----
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-
V
P
-
V
R
---
T
--
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
------
F
-
P
-
K
-
W
A
---------------
R
Q
D
---
F
S
K
V
V
P
P
L
-------
D
E
D
GRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
-
Q
D
V
T
K
---
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------