@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK14_HUMAN: (2021-11-22 )
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
Atome Classification :
(508 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130..-.....140.......150..-.....160......-.-170-.-.......180.......---190.......200-----..----.-.-----....210.......220.---.-----.-.-...230--.......240.......250.......260...-.-...270.......280....----...290.......300.......310.......320.....-..330.......340.......350.......360.......370..-..-...380.---.---..--...390..-------......400.......410.......420.......430.......440.......450.......460.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MCDLIEP
Q
P
A
E
K
I
G
K
M
K
K
L
R
R
T
L
S
E
S
F
S
R
IALKKDDT
T
F
D
E
I
C
V
T
KMSTRNCQ
G
M
D
S
V
I
K
P
L
DTIPEDK
K
V
R
V
Q
RTQSTFD
P
F
E
K
P
A
N
Q
V
K
R
V
HSEN
N
A
C
I
N
F
K
TSSTGKESPKVRRHSSPSSPTSPKFGKAD
S
-
Y
E
K
L
E
K
LGEG
S
Y
A
T
V
YKGKS-KVN
G
K
L
V
A
L
K
V
I
R
L
-Q-E-E-E-GTP
F
T
A
I
R
E
A
S
L
L
K
GLK---HA
N
I
V
L
L
H
D
I
IH------T
K
----
E
-
T
-----
L
T
L
V
F
E
Y
V
H
T
D
L
C
Q
Y
M
DK---H-----P-G-GLHP
D
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
S
Y
I
H
Q
R
Y
I
L
HRDLKPQ
N
L
L
IS-D-TG
E
L
K
L
ADFGL
A
R
A
KSVPSH----TYSN
E
V
V
T
L
W
YR
P
P
D
V
L
LGST
E
Y
S
T
C
L
D
M
W
G
V
G
C
I
F
V
E
M
I
Q
-
G
V
AAFP
G
M
K
D
I
Q
D
Q
L
E
R
I
F
L
V
L
GTPNEDTWPGVHSLPHFKPE
R
F
T
L
Y-SS-K
N
L
R
Q
A
W
---
N
---
K
L--SYV
N
H
-
A
E
-------
D
L
A
S
K
L
L
QCSPKNR
L
S
A
Q
A
A
L
S
H
E
Y
F
SDL
P
P
R
L
W
E
LTDMS
S
I
F
TVPN
V
R
LQPEAG
E
S
M
R
A
FGKNNSYGKSLSNSKH
21
Blastp_CBE
93.51
59%
-122
- C1 -
-
5G6V
3
CDK16_HUMAN
B:
[2-314]
------------------------------------------------------------------------------------------------------------------------------------
E
T
-
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
-
E
-
H
-
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
E
----
K
-
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
-----
G
-
N
-
I
I
N
M
H
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
----------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
-
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
N
Y
P
K
Y
-
R
A
-
E
A
L
L
S
H
A
---
P
---
R
L
--
D
--
S
D
-
G
A
-------
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
--
S
-------------------
2
PsiBlast_PDB
92.19
59%
-110
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[2-313]
------------------------------------------------------------------------------------------------------------------------------------
E
T
-
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
-
E
-
H
-
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
E
----
K
-
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
-----
G
-
N
-
I
I
N
M
H
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
-
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
N
Y
P
K
Y
-
R
A
-
E
A
L
L
S
H
A
---
P
---
R
L
--
D
--
S
D
-
G
A
-------
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
----------------------
1
PsiBlast_PDB
90.92
59%
-117
- C1 -
-
3MTL
-
CDK16_HUMAN
A:
[2-312]
------------------------------------------------------------------------------------------------------------------------------------
E
T
-
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
-----------
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
E
----
K
-
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
-----
G
-
N
-
I
I
N
M
H
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
----------------
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
-
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
N
Y
P
K
Y
-
R
A
-
E
A
L
L
S
H
A
---
P
---
R
L
--
D
--
S
D
-
G
A
-------
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
-----------------------
550
HHSearch
86.83
60%
-116
- C1 -
-
3MTL
-
CDK16_HUMAN
A:
[2-305]
------------------------------------------------------------------------------------------------------------------------------------
E
T
-
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
-----------
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
E
----
K
-
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
-----
G
-
N
-
I
I
N
M
H
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
----------------
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
-
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
N
Y
P
K
Y
-
R
A
-
E
A
L
L
S
-----
H
---
A
P
--
R
L
D
S
D
-
G
A
-------
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
------------------------------
9
PsiBlast_PDB
86.47
52%
-87
- C1 -
-
3NIZ
1
?
A:
[18-311]
---------------------------------------------------------------------------------------------------------------------------------
G
L
M
E
K
-
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
-
S
-
Q
G
R
I
V
A
L
K
R
I
R
----------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
---
H
P
N
I
V
S
L
I
D
V
I
H
------
S
E
----
R
-
C
-----
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
-----
K
-
T
-
G
L
Q
D
S
Q
--
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-------
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
-
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
Q
R
T
F
Q
V
F
-
E
K
-
K
----
P
W
---
S
---
S
I
IP
G
F
C
Q
E
-
G
I
-------
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-------------------------------------------
28
Blastp_CBE
84.53
52%
-116
- C1 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-286]
-------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
-
G
E
T
F
A
L
K
K
I
R
L
--------------
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
K
----
K
-
R
-----
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
-
G
L
E
S
V
T
--
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
-
N
F
T
V
Y
-
E
P
-
L
P
W
E
S
F
L
---
K
---
G
L
--
D
--
E
S
-
G
I
-------
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
------------------------------------------------
17
PsiBlast_PDB
84.35
52%
-123
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-286]
-------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
-
G
E
T
F
A
L
K
K
I
R
L
------------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
K
----
K
-
R
-----
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
-
G
L
E
S
V
T
--
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
-
N
F
T
V
Y
-
E
P
-
L
P
W
E
S
F
L
---
K
---
G
L
--
D
--
E
S
-
G
I
-------
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
------------------------------------------------
551
HHSearch
83.03
61%
-65
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[2-305]
------------------------------------------------------------------------------------------------------------------------------------
E
T
-
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
-
E
-
H
-
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
E
----
K
-
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
-----
G
-
N
-
I
I
N
M
H
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
-
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
N
Y
P
------
K
Y
R
A
E
A
L
---
L
SH-
A
P
--
R
L
D
S
D
-
G
A
-------
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
------------------------------
554
HHSearch
81.77
53%
-96
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[6-293]
------------------------------------------------------------------------------------------------------------------------------------
Q
K
-
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
-------
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
-----
K
-
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
----------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
--
P
M
Y
-
P
A
-
T
--
T
S
L
V
---
N
V--
V
P
--
K
L
N
A
T
-
G
R
-------
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----------------------------------------------
225
Blastp_CBE
81.62
52%
-63
- C1 -
-
2UZO
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
434
Blastp_CBE
81.59
52%
-52
- C1 -
-
2IW9
1
CDK2_HUMAN
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
269
Blastp_CBE
81.35
52%
-57
- C1 -
-
1Y8Y
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
248
Blastp_CBE
81.28
52%
-58
- C1 -
-
2C5Y
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
30
Blastp_CBE
81.27
52%
-131
- C1 -
-
1V0P
1
CDC2H_PLAFK
B:
[2-286]
------------------------------------------------------------------------------------------------------------------------------------
E
K
-
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
-
G
E
T
F
A
L
K
---------------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
-------------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
-
G
L
E
S
V
T
--
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
-----------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
-
N
F
T
V
Y
-
E
P
-
L
P
W
E
S
F
L
---
K
---
G
L
--
D
--
E
S
-
G
I
-------
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
------------------------------------------------
348
Blastp_CBE
81.23
52%
-57
- C1 -
-
4ERW
17
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
S
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
154
Blastp_CBE
80.95
52%
-57
- C1 -
-
4FKU
3
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
22
Blastp_CBE
80.94
55%
-61
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[8-293]
---------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
-------
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
-----
K
-
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
----------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
P
M
Y
P
A
T
-
T
S
L
V
N
V
V
---
P
---
K
L
--
N
A
T
---
G
R
-------
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----------------------------------------------
240
Blastp_CBE
80.92
52%
-51
- C1 -
-
2CLX
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
282
Blastp_CBE
80.88
52%
-59
- C1 -
-
1PXK
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
354
Blastp_CBE
80.86
52%
-47
- C1 -
-
4EOS
1
CDK2_HUMAN
A:
[2-292]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
200
Blastp_CBE
80.76
52%
-50
- C1 -
-
2XMY
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
429
Blastp_CBE
80.64
52%
-55
- C1 -
-
2R3I
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
38
Blastp_CBE
80.70
52%
-54
- C1 -
-
6Q4C
1
CDK2_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
161
Blastp_CBE
80.64
52%
-55
- C1 -
-
4FKL
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
339
Blastp_CBE
80.56
51%
-56
- C1 -
-
5OO3
1
CDK2_HUMAN
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
189
Blastp_CBE
80.53
52%
-56
- C1 -
-
3IGG
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
338
Blastp_CBE
80.43
51%
-53
- C1 -
-
5OSM
1
CDK2_HUMAN
A:
[3-294]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
230
Blastp_CBE
80.38
52%
-55
- C1 -
-
2R3R
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
241
Blastp_CBE
80.34
52%
-54
- C1 -
-
2C6O
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
281
Blastp_CBE
80.32
52%
-59
- C1 -
-
1PXL
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
33
Blastp_CBE
80.29
52%
-55
- C1 -
-
6Q4K
3
CDK2_HUMAN
A:
[8-297]
--------------------------------------------------------------------------------------------------------------------------------
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
35
Blastp_CBE
80.19
52%
-57
- C1 -
-
6Q4H
2
CDK2_HUMAN
A:
[8-297]
--------------------------------------------------------------------------------------------------------------------------------
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
430
Blastp_CBE
80.16
52%
-53
- C1 -
-
1W8C
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
W
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
315
Blastp_CBE
79.89
52%
-57
- C1 -
-
1B38
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
346
Blastp_CBE
79.93
52%
-53
- C1 -
-
6Q3F
1
CDK2_HUMAN
A:
[5-297]
-----------------------------------------------------------------------------------------------------------------------------
S
P
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
341
Blastp_CBE
79.93
51%
-52
- C1 -
-
5MHQ
1
?
A:
[6-297]
------------------------------------------------------------------------------------------------------------------------------
P
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
L
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
247
Blastp_CBE
79.99
52%
-53
- C1 -
-
2C68
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
314
Blastp_CBE
79.95
52%
-59
- C1 -
-
1B39
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
242
Blastp_CBE
79.93
52%
-53
- C1 -
-
2C6M
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
160
Blastp_CBE
79.91
52%
-58
- C1 -
-
4FKO
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
245
Blastp_CBE
79.89
52%
-58
- C1 -
-
2C6I
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
438
Blastp_CBE
79.88
51%
-52
- C1 -
-
4EOO
1
CDK2_HUMAN
A:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
498
Blastp_CBE
79.73
51%
-46
- C1 -
-
4EOI
2
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
422
Blastp_CBE
79.72
52%
-52
- C1 -
-
2R3P
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
496
Blastp_CBE
79.77
51%
-46
- C1 -
-
4EOK
1
CDK2_HUMAN
A:
[3-292]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
492
Blastp_CBE
79.76
51%
-45
- C1 -
-
4EOJ
1
CDK2_HUMAN
A:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
423
Blastp_CBE
79.73
52%
-53
- C1 -
-
2R3O
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
310
Blastp_CBE
79.72
52%
-52
- C1 -
-
1E1V
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
40
Blastp_CBE
79.55
52%
-51
- C1 -
-
6Q4A
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
244
Blastp_CBE
79.52
52%
-52
- C1 -
-
2C6K
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
46
Blastp_CBE
79.49
52%
-6
- C1 -
-
4GCJ
5
CDK2_HUMAN
A:
[5-297]
-----------------------------------------------------------------------------------------------------------------------------
S
P
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
224
Blastp_CBE
79.47
52%
-51
- C1 -
-
2V0D
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
185
Blastp_CBE
79.40
52%
-51
- C1 -
-
3LFS
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
7
PsiBlast_PDB
79.25
54%
-21
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[4-291]
---------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
-
D
-
D
-
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
D
----
K
-
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
P
M
Y
P
A
T
-
T
S
L
V
N
V
V
---
P
---
K
L
--
N
A
T
---
G
R
-------
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
---------------------------------------------
168
Blastp_CBE
79.24
52%
-53
- C1 -
-
4EK4
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
406
Blastp_CBE
79.22
52%
-11
- C1 -
-
4CFN
1
CDK2_HUMAN
C:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
447
Blastp_CBE
79.15
52%
-50
- C1 -
-
4EOR
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
15
PsiBlast_PDB
79.11
51%
-56
- C1 -
-
6Q4G
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
418
Blastp_CBE
78.99
52%
-11
- C1 -
-
3QHR
2
CDK2_HUMAN
C:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
134
Blastp_CBE
79.08
52%
-54
- C1 -
-
5JQ5
1
CDK2_HUMAN
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
299
Blastp_CBE
78.99
52%
-53
- C1 -
-
1H07
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
163
Blastp_CBE
78.95
52%
-51
- C1 -
-
4FKI
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
246
Blastp_CBE
78.91
52%
-55
- C1 -
-
2C69
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
213
Blastp_CBE
78.87
52%
-49
- C1 -
-
2VTR
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
268
Blastp_CBE
78.79
52%
-56
- C1 -
-
1Y91
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
218
Blastp_CBE
78.79
52%
-51
- C1 -
-
2VTM
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
243
Blastp_CBE
78.81
52%
-53
- C1 -
-
2C6L
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
184
Blastp_CBE
78.80
52%
-52
- C1 -
-
3NS9
1
CDK2_HUMAN
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
34
Blastp_CBE
78.79
52%
-58
- C1 -
-
6Q4J
2
CDK2_HUMAN
A:
[8-297]
--------------------------------------------------------------------------------------------------------------------------------
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
375
Blastp_CBE
78.74
51%
-14
- C1 -
-
1H1P
1
CDK2_HUMAN
A:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
309
Blastp_CBE
78.73
52%
-50
- C1 -
-
1E1X
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
265
Blastp_CBE
78.72
52%
-56
- C1 -
-
2A4L
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
500
Blastp_CBE
78.48
51%
-10
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
31
Blastp_CBE
78.61
52%
-30
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[2-286]
------------------------------------------------------------------------------------------------------------------------------------
E
K
-
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
-
G
E
T
F
A
L
K
K
I
R
L
-
E
K
E
-
D
-
E
-
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
K
----
K
-
R
-----
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
-
G
L
E
S
V
T
--
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
-------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
-
N
F
T
V
Y
-
E
P
-
L
P
W
E
S
F
L
---
K
---
G
L
--
D
--
E
S
-
G
I
-------
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
------------------------------------------------
191
Blastp_CBE
78.55
52%
-55
- C1 -
-
3FZ1
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
167
Blastp_CBE
78.55
52%
-53
- C1 -
-
4EK5
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
495
Blastp_CBE
78.52
51%
-7
- C1 -
-
4EOK
1
CDK2_HUMAN
C:
[1-292]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
280
Blastp_CBE
78.45
52%
-52
- C1 -
-
1PXM
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
421
Blastp_CBE
78.50
52%
-51
- C1 -
-
2R3Q
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
186
Blastp_CBE
78.48
52%
-51
- C1 -
-
3LFQ
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
306
Blastp_CBE
78.46
52%
-15
- C1 -
-
1FIN
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
136
Blastp_CBE
78.45
52%
-59
- C1 -
-
5IEX
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
233
Blastp_CBE
78.44
52%
-53
- C1 -
-
2R3F
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
368
Blastp_CBE
78.39
51%
-5
- C1 -
-
1H1S
1
CDK2_HUMAN
C:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
232
Blastp_CBE
78.35
52%
-51
- C1 -
-
2R3G
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
402
Blastp_CBE
78.34
52%
-10
- C1 -
-
6GUC
1
CDK2_HUMAN
C:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
219
Blastp_CBE
78.33
52%
-52
- C1 -
-
2VTL
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
324
Blastp_CBE
78.25
52%
-15
- C1 -
-
2WPA
1
CDK2_HUMAN
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
111
Blastp_CBE
78.31
52%
-57
- C1 -
-
3QTR
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
188
Blastp_CBE
78.23
52%
-49
- C1 -
-
3LE6
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
158
Blastp_CBE
78.24
52%
-56
- C1 -
-
4FKQ
2
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
39
Blastp_CBE
78.23
52%
-51
- C1 -
-
6Q4B
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
231
Blastp_CBE
78.20
52%
-51
- C1 -
-
2R3H
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
345
Blastp_CBE
78.19
52%
-51
- C1 -
-
6Q4F
1
CDK2_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
294
Blastp_CBE
78.18
52%
-55
- C1 -
-
1JSV
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
56
Blastp_CBE
78.17
52%
-59
- C1 -
-
3RPR
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
357
Blastp_CBE
78.16
51%
-12
- C1 -
-
5NEV
1
?
C:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
129
Blastp_CBE
78.12
52%
-50
- C1 -
-
6Q4I
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
L
---
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
296
Blastp_CBE
78.11
52%
-58
- C1 -
-
1H0W
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
312
Blastp_CBE
78.10
52%
-54
- C1 -
-
1DI8
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
499
Blastp_CBE
78.08
51%
-9
- C1 -
-
4EON
1
CDK2_HUMAN
C:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
297
Blastp_CBE
78.07
52%
-50
- C1 -
-
1H0V
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
71
Blastp_CBE
78.05
52%
-58
- C1 -
-
3RAH
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
419
Blastp_CBE
78.03
52%
-10
- C1 -
-
3QHR
6
CDK2_HUMAN
A:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
360
Blastp_CBE
77.97
51%
-9
- C1 -
-
5CYI
1
CDK2_HUMAN
A:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
86
Blastp_CBE
77.95
52%
-57
- C1 -
-
3R7I
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
37
Blastp_CBE
77.94
52%
-54
- C1 -
-
6Q4D
6
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
415
Blastp_CBE
77.92
52%
-10
- C1 -
-
1OGU
1
CDK2_HUMAN
A:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
334
Blastp_CBE
77.87
52%
-17
- C1 -
-
2BKZ
1
CDK2_HUMAN
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
347
Blastp_CBE
77.77
52%
-52
- C1 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-297]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
378
Blastp_CBE
77.83
52%
-12
- C1 -
-
4BCM
1
CDK2_HUMAN
C:
[3-292]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
298
Blastp_CBE
77.82
52%
-54
- C1 -
-
1H08
2
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
413
Blastp_CBE
77.81
52%
-10
- C1 -
-
1OI9
1
CDK2_HUMAN
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
385
Blastp_CBE
77.78
52%
-10
- C1 -
-
4BCN
1
CDK2_HUMAN
C:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
267
Blastp_CBE
77.73
52%
-7
- C1 -
-
1YKR
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
85
Blastp_CBE
77.77
52%
-57
- C1 -
-
3R7U
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
47
Blastp_CBE
77.74
52%
-3
- C1 -
-
4EZ7
7
CDK2_HUMAN
A:
[5-297]
-----------------------------------------------------------------------------------------------------------------------------
S
P
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
130
Blastp_CBE
77.73
52%
-53
- C1 -
-
5K4J
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
45
Blastp_CBE
77.72
52%
-50
- C1 -
-
6GUH
3
CDK2_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
3
PsiBlast_PDB
77.71
54%
-52
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[8-293]
---------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
-------------
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
--------------
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
------
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
P
M
Y
P
A
T
-
T
S
L
V
N
V
V
---
P
---
K
L
--
N
A
T
---
G
R
-------
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----------------------------------------------
453
Blastp_CBE
77.66
52%
-10
- C1 -
-
2UZL
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
458
Blastp_CBE
77.65
52%
-18
- C1 -
-
2UZB
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
416
Blastp_CBE
77.55
52%
-9
- C1 -
-
3QHW
3
CDK2_HUMAN
C:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
13
PsiBlast_PDB
77.63
52%
-26
- C1 -
-
4KRC
1
PHO85_YEAST
A:
[4-299]
-----------------------------------------------------------------------------------------------------------------------------------
S
S
Q
-
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
-
K
T
T
G
V
Y
V
A
L
K
E
V
K
L
-
D
-
S
-
E
-
E
-
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
I
H
------
T
E
----
N
-
K
-----
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
---
R
T----
P
-
R
-
G
L
E
L
N
L
--
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
T
N
D
-
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
P
N
-
I
Q
Q
R
-
P
P
-
R
D
L
R
Q
V
L
---
Q
PHT
K
E
--
P
L
D
G
N
-
L
M
-------
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
------------------------------------------------
333
Blastp_CBE
77.61
52%
-18
- C1 -
-
2BKZ
1
CDK2_HUMAN
C:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
417
Blastp_CBE
77.50
52%
-8
- C1 -
-
3QHW
2
CDK2_HUMAN
A:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
483
Blastp_CBE
77.56
52%
-10
- C1 -
-
1QMZ
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
493
Blastp_CBE
77.43
51%
-10
- C1 -
-
4EOL
1
CDK2_HUMAN
C:
[1-292]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
490
Blastp_CBE
77.43
52%
-9
- C1 -
-
2IW8
1
CDK2_HUMAN
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
152
Blastp_CBE
77.55
52%
-62
- C1 -
-
4FKW
2
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
497
Blastp_CBE
77.53
51%
-11
- C1 -
-
4EOI
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
177
Blastp_CBE
77.50
52%
-55
- C1 -
-
3ULI
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
439
Blastp_CBE
77.39
51%
-6
- C1 -
-
4EOP
1
CDK2_HUMAN
C:
[3-292]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
149
Blastp_CBE
77.48
52%
-6
- C1 -
-
4KD1
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
135
Blastp_CBE
77.47
52%
-55
- C1 -
-
5IEY
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
358
Blastp_CBE
77.43
51%
-9
- C1 -
-
5NEV
1
CDK2_HUMAN
A:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
370
Blastp_CBE
77.42
51%
-10
- C1 -
-
1H1R
1
CDK2_HUMAN
C:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
303
Blastp_CBE
77.41
52%
-14
- C1 -
-
1FVV
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
475
Blastp_CBE
77.29
52%
-14
- C1 -
-
3DDP
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
411
Blastp_CBE
77.40
52%
-11
- C1 -
-
1OIU
1
CDK2_HUMAN
A:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
359
Blastp_CBE
77.39
51%
-8
- C1 -
-
5CYI
1
CDK2_HUMAN
C:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
521
Blastp_CBE
77.34
42%
-112
- C1 -
-
1UA2
1
CDK7_HUMAN
B:
[13-299]
----------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
-------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
K
----
S
-
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
-
V
L
T
P
S
H
--
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
-
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
--
T
F
K
S
F
-
P
G
-
I
P
L
H
H
I
F
---
S
---
A
A
--
G
--
D
D
-
L
L
-------
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
----------------------------------------------
382
Blastp_CBE
77.33
52%
-8
- C1 -
-
4BCP
1
CDK2_HUMAN
A:
[2-291]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
192
Blastp_CBE
77.27
52%
-14
- C1 -
-
3F5X
2
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
153
Blastp_CBE
77.29
52%
-54
- C1 -
-
4FKV
2
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
215
Blastp_CBE
77.24
52%
-51
- C1 -
-
2VTP
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
143
Blastp_CBE
77.27
52%
-57
- C1 -
-
5ANI
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
470
Blastp_CBE
77.14
52%
-8
- C1 -
-
5L2W
2
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
207
Blastp_CBE
77.24
52%
-51
- C1 -
-
2W06
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
362
Blastp_CBE
77.15
51%
-14
- C1 -
-
4CFX
1
CDK2_HUMAN
A:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
73
Blastp_CBE
77.21
52%
-57
- C1 -
-
3R9N
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
369
Blastp_CBE
77.13
51%
-13
- C1 -
-
1H1S
1
CDK2_HUMAN
A:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
440
Blastp_CBE
77.19
51%
-12
- C1 -
-
4EOP
1
CDK2_HUMAN
A:
[2-292]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
366
Blastp_CBE
77.11
51%
-6
- C1 -
-
4CFM
1
CDK2_HUMAN
A:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
478
Blastp_CBE
77.18
52%
-8
- C1 -
-
2G9X
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
204
Blastp_CBE
77.16
52%
-13
- C1 -
-
2WEV
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
562
HHSearch
77.02
43%
-111
- C1 -
-
1UA2
1
CDK7_HUMAN
B:
[13-299]
----------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
-------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
K
----
S
-
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
-
V
L
T
P
S
H
--
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
-
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
T
--
F
K
S
F
-
P
G
-
I
P
L
H
H
I
--------
F
S
--
A
A
G
D
D
-
L
L
-------
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
----------------------------------------------
5
PsiBlast_PDB
77.15
54%
-29
- C1 -
-
1UNG
1
CDK5_HUMAN
A:
[4-291]
---------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
-
D
-
D
-
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
D
----
K
-
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
P
M
Y
P
A
T
-
T
S
L
V
N
V
V
---
P
---
K
L
--
N
A
T
---
G
R
-------
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
P
---------------------------------------------
44
Blastp_CBE
77.14
52%
-58
- C1 -
-
6GUK
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
322
Blastp_CBE
77.13
52%
-13
- C1 -
-
2WXV
1
CDK2_HUMAN
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
181
Blastp_CBE
77.12
52%
-61
- C1 -
-
3SW7
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
435
Blastp_CBE
77.02
52%
-12
- C1 -
-
2IW6
1
CDK2_HUMAN
C:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
256
Blastp_CBE
77.11
52%
-16
- C1 -
-
2C5N
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
237
Blastp_CBE
77.10
52%
-53
- C1 -
-
2FVD
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------------
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
444
Blastp_CBE
76.99
52%
-8
- C1 -
-
1E9H
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
364
Blastp_CBE
77.09
51%
-13
- C1 -
-
4CFW
1
CDK2_HUMAN
A:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
455
Blastp_CBE
76.98
52%
-13
- C1 -
-
2UZE
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
371
Blastp_CBE
77.00
51%
-6
- C1 -
-
1H1R
1
CDK2_HUMAN
A:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
43
Blastp_CBE
77.03
52%
-56
- C1 -
-
6Q3B
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
350
Blastp_CBE
77.02
52%
-10
- C1 -
-
4CFV
1
CDK2_HUMAN
A:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
408
Blastp_CBE
76.92
52%
-9
- C1 -
-
1OIY
1
CDK2_HUMAN
C:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
110
Blastp_CBE
77.00
52%
-57
- C1 -
-
3QTS
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
384
Blastp_CBE
76.84
52%
-8
- C1 -
-
4BCO
1
CDK2_HUMAN
A:
[2-291]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
54
Blastp_CBE
77.00
52%
-59
- C1 -
-
3RPY
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
114
Blastp_CBE
76.99
52%
-10
- C1 -
-
3QRT
3
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
120
Blastp_CBE
76.98
52%
-9
- C1 -
-
3QQF
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
485
Blastp_CBE
76.84
52%
-9
- C1 -
-
1P5E
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
449
Blastp_CBE
76.83
52%
-8
- C1 -
-
4I3Z
4
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
412
Blastp_CBE
76.83
52%
-11
- C1 -
-
1OI9
1
CDK2_HUMAN
C:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
361
Blastp_CBE
76.92
51%
-10
- C1 -
-
4CFX
1
CDK2_HUMAN
C:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
388
Blastp_CBE
76.90
52%
-4
- C1 -
-
4BCK
2
CDK2_HUMAN
A:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
174
Blastp_CBE
76.88
52%
-59
- C1 -
-
3WBL
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
T
G
E
V
V
A
L
K
K
I
R
L
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
252
Blastp_CBE
76.86
52%
-17
- C1 -
-
2C5V
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
253
Blastp_CBE
76.84
52%
-13
- C1 -
-
2C5O
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
228
Blastp_CBE
76.83
52%
-13
- C1 -
-
2UUE
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
379
Blastp_CBE
76.75
52%
-12
- C1 -
-
4BCM
1
CDK2_HUMAN
A:
[2-292]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
254
Blastp_CBE
76.81
52%
-14
- C1 -
-
2C5O
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
332
Blastp_CBE
76.79
52%
-13
- C1 -
-
2BPM
1
CDK2_HUMAN
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
374
Blastp_CBE
76.78
51%
-14
- C1 -
-
1H1P
1
CDK2_HUMAN
C:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
409
Blastp_CBE
76.59
52%
-9
- C1 -
-
1OIY
1
CDK2_HUMAN
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
494
Blastp_CBE
76.77
51%
-8
- C1 -
-
4EOL
1
CDK2_HUMAN
A:
[3-292]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
------L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
150
Blastp_CBE
76.75
52%
-11
- C1 -
-
4FX3
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
462
Blastp_CBE
76.63
52%
-12
- C1 -
-
2C6T
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
457
Blastp_CBE
76.63
52%
-10
- C1 -
-
2UZD
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
328
Blastp_CBE
76.72
52%
-10
- C1 -
-
2WIH
1
CDK2_HUMAN
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
407
Blastp_CBE
76.63
52%
-10
- C1 -
-
4CFN
1
CDK2_HUMAN
A:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
48
Blastp_CBE
76.69
52%
-7
- C1 -
-
4EZ3
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
190
Blastp_CBE
76.66
52%
-56
- C1 -
-
3IG7
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
376
Blastp_CBE
76.68
52%
-8
- C1 -
-
4BCQ
1
CDK2_HUMAN
C:
[3-292]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
502
Blastp_CBE
76.54
51%
-13
- C1 -
-
4EOM
1
CDK2_HUMAN
A:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
23
Blastp_CBE
76.66
54%
-70
- C1 -
-
3O0G
1
CDK5_HUMAN
B:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------
K
L
E
K
I
-----
G
T
V
F
K
A
-------
E
I
V
A
L
K
R
V
R
------------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
D
----
K
-
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
P
M
Y
P
A
T
-
T
S
L
V
N
V
V
---
P
---
K
L
--
N
A
T
---
G
R
-------
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
------------------------------------------------
212
Blastp_CBE
76.63
52%
-57
- C1 -
-
2VTS
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
353
Blastp_CBE
76.62
52%
-13
- C1 -
-
4EOS
1
CDK2_HUMAN
C:
[3-292]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
445
Blastp_CBE
76.61
52%
-9
- C1 -
-
1E9H
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
227
Blastp_CBE
76.59
52%
-12
- C1 -
-
2UUE
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
66
Blastp_CBE
76.58
52%
-6
- C1 -
-
3RK5
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
450
Blastp_CBE
76.47
52%
-12
- C1 -
-
4II5
3
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
476
Blastp_CBE
76.44
52%
-6
- C1 -
-
3DDP
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
400
Blastp_CBE
76.55
52%
-11
- C1 -
-
6GUF
1
CDK2_HUMAN
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
113
Blastp_CBE
76.54
52%
-10
- C1 -
-
3QRU
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
137
Blastp_CBE
76.52
52%
-56
- C1 -
-
5IEV
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
486
Blastp_CBE
76.51
52%
-16
- C1 -
-
1P5E
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
389
Blastp_CBE
76.41
52%
-8
- C1 -
-
3TNW
1
CDK2_HUMAN
C:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
103
Blastp_CBE
76.47
52%
-9
- C1 -
-
3QWK
5
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
335
Blastp_CBE
76.40
52%
-14
- C1 -
-
1VYW
1
CDK2_HUMAN
C:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
484
Blastp_CBE
76.34
52%
-11
- C1 -
-
1QMZ
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
481
Blastp_CBE
76.34
52%
-13
- C1 -
-
2CCH
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
437
Blastp_CBE
76.46
51%
-9
- C1 -
-
4EOO
1
CDK2_HUMAN
C:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
436
Blastp_CBE
76.34
52%
-14
- C1 -
-
2IW6
1
CDK2_HUMAN
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
392
Blastp_CBE
76.43
52%
-12
- C1 -
-
3MY5
3
CDK2_HUMAN
A:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
216
Blastp_CBE
76.42
52%
-56
- C1 -
-
2VTO
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
157
Blastp_CBE
76.41
52%
-56
- C1 -
-
4FKR
2
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
209
Blastp_CBE
76.34
52%
-61
- C1 -
-
2VV9
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
133
Blastp_CBE
76.40
52%
-57
- C1 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
352
Blastp_CBE
76.32
52%
-8
- C1 -
-
4CFU
1
CDK2_HUMAN
A:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
336
Blastp_CBE
76.39
52%
-15
- C1 -
-
1VYW
1
CDK2_HUMAN
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
387
Blastp_CBE
76.38
52%
-12
- C1 -
-
4BCK
1
CDK2_HUMAN
C:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
64
Blastp_CBE
76.37
52%
-7
- C1 -
-
3RK9
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
472
Blastp_CBE
76.25
52%
-12
- C1 -
-
3DOG
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
193
Blastp_CBE
76.34
52%
-18
- C1 -
-
3F5X
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
480
Blastp_CBE
76.33
52%
-12
- C1 -
-
2CCI
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
72
Blastp_CBE
76.32
52%
-53
- C1 -
-
3R9O
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
81
Blastp_CBE
76.30
52%
-6
- C1 -
-
3R8L
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
452
Blastp_CBE
76.29
52%
-10
- C1 -
-
2UZL
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
329
Blastp_CBE
76.22
52%
-13
- C1 -
-
2C4G
1
CDK2_HUMAN
C:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
459
Blastp_CBE
76.17
52%
-12
- C1 -
-
2UZB
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
291
Blastp_CBE
76.22
52%
-65
- C1 -
-
1KE6
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
443
Blastp_CBE
76.16
52%
-14
- C1 -
-
1PKD
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
305
Blastp_CBE
76.26
52%
-57
- C1 -
-
1FVT
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
155
Blastp_CBE
76.24
52%
-53
- C1 -
-
4FKT
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
151
Blastp_CBE
76.24
52%
-9
- C1 -
-
4FX3
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
386
Blastp_CBE
76.25
52%
-12
- C1 -
-
4BCN
1
CDK2_HUMAN
A:
[2-291]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
79
Blastp_CBE
76.24
52%
-6
- C1 -
-
3R8P
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
50
Blastp_CBE
76.22
52%
-60
- C1 -
-
3S1H
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
394
Blastp_CBE
76.13
52%
-9
- C1 -
-
3BHV
2
CDK2_HUMAN
A:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
330
Blastp_CBE
76.21
52%
-12
- C1 -
-
2C4G
1
CDK2_HUMAN
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
313
Blastp_CBE
76.19
52%
-63
- C1 -
-
1CKP
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
289
Blastp_CBE
76.18
52%
-58
- C1 -
-
1KE8
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
121
Blastp_CBE
76.17
52%
-7
- C1 -
-
3QL8
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
373
Blastp_CBE
76.09
51%
-9
- C1 -
-
1H1Q
1
CDK2_HUMAN
A:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
396
Blastp_CBE
76.16
52%
-8
- C1 -
-
3BHU
1
CDK2_HUMAN
A:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
91
Blastp_CBE
76.15
52%
-6
- C1 -
-
3R28
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
456
Blastp_CBE
76.03
52%
-20
- C1 -
-
2UZD
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
102
Blastp_CBE
76.13
52%
-8
- C1 -
-
3QX2
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
285
Blastp_CBE
76.12
52%
-10
- C1 -
-
1PF8
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
307
Blastp_CBE
76.06
52%
-9
- C1 -
-
1FIN
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
323
Blastp_CBE
76.11
52%
-11
- C1 -
-
2WPA
1
CDK2_HUMAN
C:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
279
Blastp_CBE
76.04
52%
-2
- C1 -
-
1PXN
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
25
Blastp_CBE
76.09
54%
-70
- C1 -
-
1UNG
1
CDK5_HUMAN
B:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
-------
T
V
F
K
A
--------
I
V
A
L
K
R
V
R
L
-
D
-------
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
D
----
K
-
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
--
Y
P
M
Y
P
A
T
-
T
S
L
V
N
V
V
---
P
---
K
L
--
N
A
T
---
G
R
-------
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-------------------------------------------------
55
Blastp_CBE
76.08
52%
-8
- C1 -
-
3RPV
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
468
Blastp_CBE
76.07
52%
-12
- C1 -
-
6GVA
3
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
451
Blastp_CBE
75.96
52%
-11
- C1 -
-
4II5
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
65
Blastp_CBE
76.06
52%
-6
- C1 -
-
3RK7
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
128
Blastp_CBE
76.04
52%
2
- C1 -
-
3PXF
7
CDK2_HUMAN
A:
[5-297]
-----------------------------------------------------------------------------------------------------------------------------
S
P
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
390
Blastp_CBE
76.05
52%
-16
- C1 -
-
3TNW
1
CDK2_HUMAN
A:
[2-291]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
69
Blastp_CBE
76.04
52%
-60
- C1 -
-
3RAK
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
57
Blastp_CBE
76.04
52%
-9
- C1 -
-
3RPO
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
327
Blastp_CBE
76.03
52%
-14
- C1 -
-
2WIH
1
CDK2_HUMAN
C:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
116
Blastp_CBE
76.02
52%
-9
- C1 -
-
3QQK
6
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
92
Blastp_CBE
76.02
52%
-6
- C1 -
-
3R1Y
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
442
Blastp_CBE
75.91
52%
-10
- C1 -
-
1PKD
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
482
Blastp_CBE
75.88
52%
-14
- C1 -
-
2CCH
3
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
448
Blastp_CBE
76.00
52%
-6
- C1 -
-
4I3Z
3
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
479
Blastp_CBE
75.84
52%
-14
- C1 -
-
2CCI
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
398
Blastp_CBE
75.96
52%
-12
- C1 -
-
3BHT
1
CDK2_HUMAN
A:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
95
Blastp_CBE
75.95
52%
-5
- C1 -
-
3QZI
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
83
Blastp_CBE
75.95
52%
-9
- C1 -
-
3R7Y
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
208
Blastp_CBE
75.91
52%
-59
- C1 -
-
2W05
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
304
Blastp_CBE
75.87
52%
-12
* C1 *
-
1FVV
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
70
Blastp_CBE
75.92
52%
-7
- C1 -
-
3RAI
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
235
Blastp_CBE
75.88
52%
-13
- C1 -
-
2I40
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
112
Blastp_CBE
75.91
52%
-7
- C1 -
-
3QTQ
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
220
Blastp_CBE
75.87
52%
-56
- C1 -
-
2VTJ
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
173
Blastp_CBE
75.87
52%
-53
- C1 -
-
4ACM
3
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
122
Blastp_CBE
75.87
52%
5
- C1 -
-
3PY1
4
CDK2_HUMAN
A:
[5-297]
-----------------------------------------------------------------------------------------------------------------------------
S
P
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
469
Blastp_CBE
75.76
52%
-12
- C1 -
-
5LMK
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
97
Blastp_CBE
75.87
52%
-9
- C1 -
-
3QZG
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
96
Blastp_CBE
75.86
52%
-4
- C1 -
-
3QZH
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
61
Blastp_CBE
75.86
52%
-7
- C1 -
-
3RM7
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
84
Blastp_CBE
75.85
52%
-5
- C1 -
-
3R7V
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
326
Blastp_CBE
75.78
52%
-15
- C1 -
-
2WIP
1
CDK2_HUMAN
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
115
Blastp_CBE
75.84
52%
-6
- C1 -
-
3QQL
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
363
Blastp_CBE
75.83
51%
-8
- C1 -
-
4CFW
1
CDK2_HUMAN
C:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
255
Blastp_CBE
75.81
52%
-9
- C1 -
-
2C5N
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
88
Blastp_CBE
75.80
52%
-8
- C1 -
-
3R73
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
454
Blastp_CBE
75.79
52%
-10
- C1 -
-
2UZE
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
100
Blastp_CBE
75.78
52%
-8
- C1 -
-
3QXO
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
94
Blastp_CBE
75.77
52%
-6
- C1 -
-
3R1Q
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
156
Blastp_CBE
75.76
52%
-58
- C1 -
-
4FKS
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
53
Blastp_CBE
75.73
52%
-53
- C1 -
-
3RZB
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
520
Blastp_CBE
75.72
42%
-111
- C1 -
-
1UA2
1
CDK7_HUMAN
C:
[13-299]
----------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
-------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
K
----
S
-
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
-
V
L
T
P
S
H
--
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
-
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
--
T
F
K
S
F
-
P
G
-
I
P
L
H
H
I
F
---
S
---
A
A
--
G
--
D
D
-
L
L
-------
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
----------------------------------------------
465
Blastp_CBE
75.71
52%
-11
- C1 -
-
1JST
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
331
Blastp_CBE
75.69
52%
-12
- C1 -
-
2BPM
1
CDK2_HUMAN
C:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
404
Blastp_CBE
75.60
52%
-6
- C1 -
-
6GUB
1
?
C:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
-------
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
19
PsiBlast_PDB
75.67
51%
-57
- C1 -
-
3EZV
1
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
170
Blastp_CBE
75.65
52%
-56
- C1 -
-
4D1X
1
CDK2_HUMAN
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
117
Blastp_CBE
75.65
52%
-9
- C1 -
-
3QQJ
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
58
Blastp_CBE
75.65
52%
-7
- C1 -
-
3ROY
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
223
Blastp_CBE
75.60
52%
-58
- C1 -
-
2VTA
3
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
89
Blastp_CBE
75.63
52%
-6
- C1 -
-
3R71
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
288
Blastp_CBE
75.57
52%
-60
- C1 -
-
1KE9
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
403
Blastp_CBE
75.62
52%
-10
- C1 -
-
6GUC
1
CDK2_HUMAN
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
229
Blastp_CBE
75.61
52%
-62
- C1 -
-
2R64
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
78
Blastp_CBE
75.60
52%
-8
- C1 -
-
3R8U
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
257
Blastp_CBE
75.57
52%
-63
- C1 -
-
2BTS
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
162
Blastp_CBE
75.56
52%
-57
- C1 -
-
4FKJ
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
171
Blastp_CBE
75.55
52%
-58
- C1 -
-
4BZD
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
127
Blastp_CBE
75.54
52%
-3
- C1 -
-
3PXQ
4
CDK2_HUMAN
A:
[5-297]
-----------------------------------------------------------------------------------------------------------------------------
S
P
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
399
Blastp_CBE
75.43
52%
-7
- C1 -
-
6GUF
1
CDK2_HUMAN
C:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
182
Blastp_CBE
75.51
52%
-57
- C1 -
-
3SW4
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
82
Blastp_CBE
75.50
52%
-8
- C1 -
-
3R83
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
555
HHSearch
75.49
53%
-9
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
Q
K
-
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
-
D
-
D
-
D
-
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
D
----
K
-
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
--
P
M
Y
-
P
A
T
T
S
L
V
N
V
--------
V
P
--
K
L
N
A
T
-
G
R
-------
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----------------------------------------------
292
Blastp_CBE
75.47
52%
-62
- C1 -
-
1KE5
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
522
Blastp_CBE
75.33
42%
-110
- C1 -
-
1UA2
1
CDK7_HUMAN
A:
[13-299]
----------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
-------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
K
----
S
-
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
-
V
L
T
P
S
H
--
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
-
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
--
T
F
K
S
F
-
P
G
-
I
P
L
H
H
I
F
---
S
---
A
A
--
G
--
D
D
-
L
L
-------
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
----------------------------------------------
178
Blastp_CBE
75.44
52%
-6
- C1 -
-
3TIZ
9
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
105
Blastp_CBE
75.44
52%
-8
- C1 -
-
3QU0
5
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
401
Blastp_CBE
75.35
52%
-10
- C1 -
-
6GUE
1
CDK2_HUMAN
C:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
-----
V
T
S
M
P
D
Y
K
P
S
-
F
P
----
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
68
Blastp_CBE
75.43
52%
-59
- C1 -
-
3RAL
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
202
Blastp_CBE
75.40
52%
-12
- C1 -
-
2X1N
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
75
Blastp_CBE
75.42
52%
-7
- C1 -
-
3R9D
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
474
Blastp_CBE
75.29
52%
-10
- C1 -
-
3DDQ
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
466
Blastp_CBE
75.29
52%
-7
- C1 -
-
1JST
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
258
Blastp_CBE
75.36
52%
-54
- C1 -
-
2BTR
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
93
Blastp_CBE
75.40
52%
-5
- C1 -
-
3R1S
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
519
Blastp_CBE
75.26
42%
-112
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-299]
----------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
-------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
K
----
S
-
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
-
V
L
T
P
S
H
--
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
-
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
--
T
F
K
S
F
-
P
G
-
I
P
L
H
H
I
F
---
S
---
A
A
--
G
--
D
D
-
L
L
-------
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
----------------------------------------------
356
Blastp_CBE
75.32
51%
-15
- C1 -
-
4EOQ
1
CDK2_HUMAN
A:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
234
Blastp_CBE
75.39
52%
-60
- C1 -
-
2J9M
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
405
Blastp_CBE
75.29
52%
-10
- C1 -
-
6GUB
1
CDK2_HUMAN
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
196
Blastp_CBE
75.35
52%
-11
- C1 -
-
3EJ1
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
277
Blastp_CBE
75.32
52%
-0
- C1 -
-
1PXP
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
199
Blastp_CBE
75.37
52%
-2
- C1 -
-
2XNB
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
59
Blastp_CBE
75.36
52%
-6
- C1 -
-
3RNI
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
87
Blastp_CBE
75.35
52%
-4
- C1 -
-
3R7E
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
67
Blastp_CBE
75.35
52%
-6
- C1 -
-
3RJC
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
145
Blastp_CBE
75.33
52%
-5
- C1 -
-
5ANE
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
273
Blastp_CBE
75.29
52%
-64
- C1 -
-
1V1K
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
98
Blastp_CBE
75.33
52%
-8
- C1 -
-
3QZF
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
60
Blastp_CBE
75.33
52%
-56
- C1 -
-
3RMF
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
274
Blastp_CBE
75.28
52%
-67
- C1 -
-
1URW
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
195
Blastp_CBE
75.32
52%
-18
- C1 -
-
3EOC
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
425
Blastp_CBE
75.31
52%
-55
- C1 -
-
2R3M
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
175
Blastp_CBE
75.29
52%
-6
- C1 -
-
3UNK
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
179
Blastp_CBE
75.28
52%
-9
- C1 -
-
3TIY
12
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
90
Blastp_CBE
75.27
52%
-7
- C1 -
-
3R6X
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
302
Blastp_CBE
75.26
52%
-62
- C1 -
-
1G5S
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
300
Blastp_CBE
75.20
52%
-54
- C1 -
-
1H00
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
99
Blastp_CBE
75.24
52%
-8
- C1 -
-
3QXP
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
463
Blastp_CBE
75.12
52%
-8
- C1 -
-
2C6T
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
210
Blastp_CBE
75.19
52%
-54
- C1 -
-
2VU3
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
----
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
249
Blastp_CBE
75.13
52%
-13
- C1 -
-
2C5X
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
290
Blastp_CBE
75.21
52%
-59
- C1 -
-
1KE7
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
104
Blastp_CBE
75.20
52%
-10
- C1 -
-
3QWJ
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
107
Blastp_CBE
75.19
52%
-10
- C1 -
-
3QTX
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
36
Blastp_CBE
75.18
52%
-57
- C1 -
-
6Q4E
3
CDK2_HUMAN
A:
[8-297]
--------------------------------------------------------------------------------------------------------------------------------
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
203
Blastp_CBE
75.15
52%
-10
- C1 -
-
2WEV
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
108
Blastp_CBE
75.17
52%
-7
- C1 -
-
3QTW
6
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
101
Blastp_CBE
75.15
52%
-9
- C1 -
-
3QX4
3
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
63
Blastp_CBE
75.15
52%
-9
- C1 -
-
3RKB
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
284
Blastp_CBE
75.09
52%
-7
- C1 -
-
1PXI
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
124
Blastp_CBE
75.14
52%
2
- C1 -
-
3PXZ
3
CDK2_HUMAN
A:
[5-297]
-----------------------------------------------------------------------------------------------------------------------------
S
P
E
F
--
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
427
Blastp_CBE
75.04
52%
-57
- C1 -
-
2R3K
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
141
Blastp_CBE
75.13
52%
-60
- C1 -
-
5ANK
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
--------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
226
Blastp_CBE
75.12
52%
-59
- C1 -
-
2UZN
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
106
Blastp_CBE
75.09
52%
-9
- C1 -
-
3QTZ
3
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
206
Blastp_CBE
75.05
52%
-58
- C1 -
-
2W17
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
222
Blastp_CBE
75.00
52%
-59
- C1 -
-
2VTH
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
125
Blastp_CBE
75.07
52%
-6
- C1 -
-
3PXY
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
420
Blastp_CBE
75.06
52%
-52
- C1 -
-
4NJ3
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
166
Blastp_CBE
75.05
52%
-53
- C1 -
-
4EK6
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
266
Blastp_CBE
75.04
52%
-5
- C1 -
-
2A0C
1
CDK2_HUMAN
X:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
172
Blastp_CBE
75.02
52%
-65
- C1 -
-
4BGH
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
488
Blastp_CBE
74.90
52%
-4
- C1 -
-
1GY3
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
118
Blastp_CBE
75.02
52%
-6
- C1 -
-
3QQH
4
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
221
Blastp_CBE
75.00
52%
-60
- C1 -
-
2VTI
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
272
Blastp_CBE
74.98
52%
-52
- C1 -
-
1VYZ
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
321
Blastp_CBE
74.91
52%
-9
- C1 -
-
2WXV
1
CDK2_HUMAN
C:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
197
Blastp_CBE
74.97
52%
-13
- C1 -
-
3EJ1
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
119
Blastp_CBE
74.93
52%
-6
- C1 -
-
3QQG
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
504
Blastp_CBE
74.79
49%
-27
- C1 -
-
6GU6
1
CDK1_HUMAN
A:
[6-295]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
D
-
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
D
----
S
-
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
-------
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
------------
K
N
T
F
P
K
W
---
K
---
P
G
--
S
L
A
S
H
-
V
K
NLDENGL
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
-----------------------------------------------
42
Blastp_CBE
74.92
52%
-56
- C1 -
-
6Q48
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
238
Blastp_CBE
74.91
52%
-3
- C1 -
-
2EXM
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
426
Blastp_CBE
74.90
52%
-60
- C1 -
-
2R3L
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
74
Blastp_CBE
74.87
52%
-8
- C1 -
-
3R9H
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
505
Blastp_CBE
74.86
49%
-23
- C1 -
-
6GU4
1
CDK1_HUMAN
A:
[3-294]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
D
-
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
D
----
S
-
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
------------
K
N
T
F
P
K
W
---
K
---
P
G
--
S
L
A
S
H
-
V
K
NLDENGL
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
------------------------------------------------
428
Blastp_CBE
74.82
52%
-56
- C1 -
-
2R3J
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
487
Blastp_CBE
74.81
52%
-11
- C1 -
-
1GY3
2
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
194
Blastp_CBE
74.80
52%
-15
- C1 -
-
3EOC
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
183
Blastp_CBE
74.78
52%
-62
- C1 -
-
3S2P
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
214
Blastp_CBE
74.79
52%
-55
- C1 -
-
2VTQ
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
176
Blastp_CBE
74.78
52%
-6
- C1 -
-
3UNJ
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
283
Blastp_CBE
74.77
52%
-3
- C1 -
-
1PXJ
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
109
Blastp_CBE
74.76
52%
-8
- C1 -
-
3QTU
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
250
Blastp_CBE
74.74
52%
-6
- C1 -
-
2C5X
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
295
Blastp_CBE
74.72
52%
-3
- C1 -
-
1HCK
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
325
Blastp_CBE
74.70
52%
-15
- C1 -
-
2WIP
1
CDK2_HUMAN
C:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
263
Blastp_CBE
74.67
52%
-2
- C1 -
-
2B53
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
123
Blastp_CBE
74.65
52%
-6
- C1 -
-
3PY0
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
320
Blastp_CBE
74.63
52%
-57
- C1 -
-
1GII
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
512
Blastp_CBE
74.49
49%
-22
- C1 -
-
4Y72
1
CDK1_HUMAN
A:
[3-294]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
D
-
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
D
----
S
-
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
------------
K
N
T
F
P
K
W
---
K
---
P
G
--
S
L
A
S
H
-
V
K
NLDENGL
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
------------------------------------------------
76
Blastp_CBE
74.61
52%
-8
- C1 -
-
3R8Z
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
--------
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
507
Blastp_CBE
74.45
49%
-25
- C1 -
-
6GU2
1
CDK1_HUMAN
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
D
-
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
D
----
S
-
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
------------
K
N
T
F
P
K
W
---
K
---
P
G
--
S
L
A
S
H
-
V
K
NLDENGL
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
-----------------------------------------------
52
Blastp_CBE
74.54
52%
-5
- C1 -
-
3S00
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
180
Blastp_CBE
74.53
52%
-7
- C1 -
-
3TI1
9
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
510
Blastp_CBE
74.49
49%
-22
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[3-294]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
D
-
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
D
----
S
-
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
------------
K
N
T
F
P
K
W
---
K
---
P
G
--
S
L
A
S
H
-
V
K
NLDENGL
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
------------------------------------------------
259
Blastp_CBE
74.45
52%
-60
- C1 -
-
2BHH
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
146
Blastp_CBE
74.38
52%
-62
- C1 -
-
5AND
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
77
Blastp_CBE
74.33
52%
-6
- C1 -
-
3R8V
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
262
Blastp_CBE
74.29
52%
-2
- C1 -
-
2B54
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
301
Blastp_CBE
74.24
52%
-58
- C1 -
-
1GIH
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
311
Blastp_CBE
74.20
52%
-61
- C1 -
-
1DM2
5
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
251
Blastp_CBE
74.17
52%
-11
- C1 -
-
2C5V
1
CDK2_HUMAN
C:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
261
Blastp_CBE
74.12
52%
-54
- C1 -
-
2B55
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
159
Blastp_CBE
74.12
52%
-56
- C1 -
-
4FKP
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
316
Blastp_CBE
74.09
52%
-52
- C1 -
-
1AQ1
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
432
Blastp_CBE
74.08
52%
-9
- C1 -
-
6GUE
1
CDK2_HUMAN
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
N
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
32
Blastp_CBE
74.07
52%
-63
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
-
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
18
PsiBlast_PDB
74.05
51%
-54
- C1 -
-
3EZR
2
CDK2_HUMAN
A:
[3-291]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
142
Blastp_CBE
74.01
52%
-8
- C1 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
319
Blastp_CBE
74.00
52%
-52
- C1 -
-
1GIJ
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
377
Blastp_CBE
73.96
52%
-4
- C1 -
-
4BCQ
1
CDK2_HUMAN
A:
[2-292]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
317
Blastp_CBE
73.87
52%
-58
- C1 -
-
6INL
1
?
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
236
Blastp_CBE
73.90
52%
-17
- C1 -
-
2I40
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
49
Blastp_CBE
73.87
52%
-8
- C1 -
-
3SQQ
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
506
Blastp_CBE
73.80
49%
-20
- C1 -
-
6GU3
1
CDK1_HUMAN
A:
[3-294]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
D
-
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
D
----
S
-
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
------------
K
N
T
F
P
K
W
---
K
---
P
G
--
S
L
A
S
H
-
V
K
NLDENGL
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
------------------------------------------------
278
Blastp_CBE
73.79
52%
-5
- C1 -
-
1PXO
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
217
Blastp_CBE
73.77
52%
-54
- C1 -
-
2VTN
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
198
Blastp_CBE
73.71
52%
-12
- C1 -
-
3EID
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
511
Blastp_CBE
73.65
49%
-27
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[5-295]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
D
-
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
D
----
S
-
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
------------
K
N
T
F
P
K
W
---
K
---
P
G
--
S
L
A
S
H
-
V
K
NLDENGL
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
-----------------------------------------------
467
Blastp_CBE
73.59
52%
-9
- C1 -
-
1FQ1
1
CDK2_HUMAN
B:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
62
Blastp_CBE
73.56
52%
-2
- C1 -
-
3RM6
2
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
239
Blastp_CBE
73.43
52%
-56
- C1 -
-
2DUV
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
275
Blastp_CBE
73.27
52%
-60
- C1 -
-
1R78
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
147
Blastp_CBE
73.14
52%
-18
- C1 -
-
5A14
2
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
211
Blastp_CBE
73.08
52%
-52
- C1 -
-
2VTT
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
51
Blastp_CBE
73.01
52%
-9
- C1 -
-
3S0O
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
12
PsiBlast_PDB
72.95
52%
-29
- C1 -
-
2PMI
2
PHO85_YEAST
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------
A
T
V
Y
K
G
L
N
-
K
T
T
G
V
Y
V
A
L
K
E
V
K
L
-
D
-
S
-
E
-
E
-
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
I
H
------
T
E
----
N
-
K
-----
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
---
R
TVGNT
P
-
R
-
G
L
E
L
N
L
--
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
T
N
D
-
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
P
N
-
I
Q
Q
R
-
P
P
-
R
D
L
R
Q
V
L
---
Q
PHT
K
E
--
P
L
D
G
N
-
L
M
-------
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
------------------------------------------------
491
Blastp_CBE
72.51
51%
-26
- C1 -
-
4EOJ
1
CDK2_HUMAN
C:
[2-293]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
--------------------
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
337
Blastp_CBE
72.25
52%
-7
- C1 -
-
3PJ8
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
144
Blastp_CBE
71.84
52%
-58
- C1 -
-
5ANG
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
148
Blastp_CBE
71.81
52%
-7
- C1 -
-
4LYN
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
276
Blastp_CBE
71.72
52%
-64
- C1 -
-
1PYE
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
187
Blastp_CBE
71.72
52%
2
- C1 -
-
3LFN
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
286
Blastp_CBE
71.57
52%
-55
- C1 -
-
1P2A
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
140
Blastp_CBE
71.38
52%
-59
- C1 -
-
5D1J
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
------------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
138
Blastp_CBE
71.07
52%
-6
- C1 -
-
5FP6
2
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
270
Blastp_CBE
70.89
52%
-9
- C1 -
-
1WCC
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
139
Blastp_CBE
70.89
52%
-55
- C1 -
-
5FP5
3
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
80
Blastp_CBE
70.80
52%
-5
- C1 -
-
3R8M
1
CDK2_HUMAN
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
340
Blastp_CBE
70.56
51%
-7
- C1 -
-
5OO1
1
CDK2_HUMAN
A:
[9-294]
---------------------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
264
Blastp_CBE
70.53
52%
0
- C1 -
-
2B52
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
169
Blastp_CBE
70.42
52%
-58
- C1 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------
N
-
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
---------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
355
Blastp_CBE
70.17
51%
-27
- C1 -
-
4EOQ
1
CDK2_HUMAN
C:
[2-293]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
513
Blastp_CBE
70.18
47%
-19
- C1 -
-
3GC0
1
?
A:
[32-323]
----------------------------------------------------------------------------------------------------------------------------------
S
I
D
R
-
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
-
T
V
T
N
E
T
V
A
I
K
R
I
R
L
-
E
H----------
T
A
I
R
E
V
S
L
L
K
E
L
Q
---
H
R
N
I
I
E
L
K
S
V
I
H
------
H
N
----
H
-
R
-----
L
H
L
I
F
E
Y
A
E
N
D
L
K
K
Y
M
D
K
---
N
-----
P
-
D
--
V
S
M
R
V
--
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
V
E
-
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
-------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
-
K
T
P
L
F
P
G
D
S
E
I
-
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
P
G
V
T
A
L
P
D
W
K
-
Q
S
F
P
K
F
-
R
G
-
K
T
L
K
R
V
L
---
G
---
A
L
--
L
D
D
E
--
G
L
-------
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
S
-------------------------------------------------
287
Blastp_CBE
70.17
52%
-63
- C1 -
-
1OIQ
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
501
Blastp_CBE
70.12
51%
-21
- C1 -
-
4EOM
1
CDK2_HUMAN
C:
[2-293]
--------------------------------------------------------------------------------------------------------------------------------
L
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
205
Blastp_CBE
69.46
52%
-3
- C1 -
-
2W1H
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
351
Blastp_CBE
69.32
52%
-21
- C1 -
-
4CFU
1
CDK2_HUMAN
C:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
393
Blastp_CBE
69.28
52%
-21
- C1 -
-
3BHV
1
CDK2_HUMAN
C:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
395
Blastp_CBE
69.11
52%
-21
- C1 -
-
3BHU
1
CDK2_HUMAN
C:
[1-291]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
397
Blastp_CBE
69.01
52%
-20
- C1 -
-
3BHT
1
CDK2_HUMAN
C:
[2-291]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
477
Blastp_CBE
68.80
52%
-17
- C1 -
-
2G9X
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
414
Blastp_CBE
68.80
52%
-18
- C1 -
-
1OGU
1
CDK2_HUMAN
C:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------
G
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
446
Blastp_CBE
68.68
52%
-24
- C1 -
-
4EOR
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
433
Blastp_CBE
68.27
52%
-21
- C1 -
-
2IW9
1
CDK2_HUMAN
C:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
424
Blastp_CBE
68.04
52%
-59
- C1 -
-
2R3N
1
CDK2_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
365
Blastp_CBE
67.82
51%
-23
- C1 -
-
4CFM
1
CDK2_HUMAN
C:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
------------------------------------
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
383
Blastp_CBE
67.81
52%
-20
- C1 -
-
4BCO
1
CDK2_HUMAN
C:
[2-291]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
489
Blastp_CBE
67.70
52%
-26
- C1 -
-
2IW8
1
CDK2_HUMAN
C:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
410
Blastp_CBE
67.54
52%
-24
- C1 -
-
1OIU
1
CDK2_HUMAN
C:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
471
Blastp_CBE
67.04
52%
-22
- C1 -
-
3DOG
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
349
Blastp_CBE
66.98
52%
-24
- C1 -
-
4CFV
1
CDK2_HUMAN
C:
[5-294]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
381
Blastp_CBE
66.92
52%
-20
- C1 -
-
4BCP
1
CDK2_HUMAN
C:
[2-291]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
473
Blastp_CBE
66.67
52%
-22
- C1 -
-
3DDQ
1
CDK2_HUMAN
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
391
Blastp_CBE
66.36
52%
-25
- C1 -
-
3MY5
1
CDK2_HUMAN
C:
[2-291]
----------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
---------------------------------
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
441
Blastp_CBE
65.81
52%
-23
- C1 -
-
5LMK
1
?
C:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
516
Blastp_CBE
65.34
43%
-6
- C1 -
-
1XO2
1
CDK6_HUMAN
B:
[11-303]
-------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
-
Q
-
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
S
-------RETK-
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
-
Q
M
----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
------
Q
A
F
-
H
----
A
Q
P
I
E
---
K
---
F
V
--
T
D
I
D
E
L
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
-----------------------------------------------
515
Blastp_CBE
63.45
43%
14
- C1 -
-
2EUF
2
CDK6_HUMAN
B:
[10-303]
------------------------------------------------------------------------------------------------------------------------------------
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
-
Q
-
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
S
----
R
-
T
DRETK
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
-
Q
M
----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
----------------------
A
Q
P
I
E
---
K
---
F
V
--
T
D
I
D
E
L
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
-----------------------------------------------
561
HHSearch
63.38
34%
-32
- C1 -
-
4NM3
5
GSK3B_HUMAN
A:
[52-344]
----------------------------------------------------------------------------------------------------------------------------------
Q
E
V
S
-
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
-
D
-
K
--------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
---
H
C
N
I
V
R
L
R
Y
F
F
Y
------
S
S
KKDE
V
-
Y
-----
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
YSR
A
-----
K
-
Q
-
T
L
P
V
I
Y
--
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
-
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-----
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
P
G
D
S
G
V
-
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
--
P
N
Y
T
E
F
K
F
P
Q
I
------
K
A
H
P
W
TKV
F
---
R
P
--
R
T
P
P
E
-
A
I
-------
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
----------------------------------------------
524
Blastp_CBE
60.60
43%
-17
- C1 -
-
5L2S
1
CDK6_HUMAN
A:
[11-300]
-------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
-----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
----------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
---
Q
A
F
H
S
K
-
S
A
-
Q
P
I
E
K
F
V
---
T
---
D
I
--
D
E
L
---
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
523
Blastp_CBE
60.20
43%
-20
- C1 -
-
5L2T
1
CDK6_HUMAN
A:
[11-300]
-------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
-------------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
----------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
---
Q
A
F
H
S
K
-
S
A
-
Q
P
I
E
K
F
V
---
T
---
D
I
--
D
E
L
---
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
532
Blastp_CBE
59.97
37%
-26
- C1 -
-
5EFQ
2
C:
[10-311]
-----------------------------------------------------------------------------------------------------------------------------------
V
D
K
-
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
-
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
-
E
-
K
-
E
-
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
---
H
Q
S
I
I
N
M
K
E
I
V
T
------
D
K
----
E
G
A
-----
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
-----
L
-
V
-
H
F
N
E
N
H
--
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
Q
E
L
A
-
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
-
Y
R
-
R
K
L
R
E
E
F
---
V
---
F
I
--
P
A
A
---
A
L
-------
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
R
D
V
E
P
---------------------------------------------
529
Blastp_CBE
59.66
43%
-26
- C1 -
-
3NUP
1
CDK6_HUMAN
A:
[12-300]
--------------------------------------------------------------------------------------------------------------------------------------Q
Y
E
C
V
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
--------------
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
--------K----
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
---
Q
A
F
H
---
S
A
-
Q
P
I
E
K
F
V
---
T
---
D
I
--
D
E
L
---
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
533
Blastp_CBE
59.53
37%
-23
- C1 -
-
5EFQ
2
CDK13_HUMAN
A:
[10-311]
-----------------------------------------------------------------------------------------------------------------------------------
V
D
K
-
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
-
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
-
E
-
K
-
E
-
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
---
H
Q
S
I
I
N
M
K
E
I
V
T
------
D
K
----
E
G
A
-----
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
-----
L
-
V
-
H
F
N
E
N
H
--
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
Q
E
L
A
-
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
-
Y
R
-
R
K
L
R
E
E
F
---
V
---
F
I
--
P
A
A
---
A
L
-------
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
R
D
V
E
P
---------------------------------------------
514
Blastp_CBE
59.28
43%
15
- C1 -
-
2F2C
2
CDK6_HUMAN
B:
[9-303]
-----------------------------------------------------------------------------------------------------------------------------------
A
D
Q
Q
Y
E
C
-
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
-
Q
-
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
S
------
T
DRETK
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
-
Q
M
----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
-------------
Q
A
F
------
A
Q
P
I
E
---
K
---
F
V
--
T
D
I
D
E
L
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
-----------------------------------------------
566
HHSearch
59.27
34%
-8
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[6-307]
-----------------------------------------------------------------------------------------------------------------------------------
G
D
E
-
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
-
A
-
F
-
D
V
V
-
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
R
PTVPYG
E
F
----
K
-
S
-----
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
---
S
-------
Q
-
P
L
T
L
E
H
--
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
-
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-
R
R
Q
L
F
P
G
K
N
Y
-
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
-
R
V
R
-
A
Y
I
Q
S
L
-
P
P
-
R
-
Q
P
V
P
W
---
E
TV-
Y
P
--
G
A
D
R
Q
-
A
L
-------
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
--------------------------------------------
528
Blastp_CBE
58.85
43%
-14
- C1 -
-
3NUX
1
CDK6_HUMAN
A:
[10-300]
------------------------------------------------------------------------------------------------------------------------------------
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
------------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
----------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
---
Q
A
F
H
-
K
-
S
A
-
Q
P
I
E
K
F
V
---
T
---
D
I
--
D
E
L
---
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
526
Blastp_CBE
58.49
43%
-15
- C1 -
-
4EZ5
1
CDK6_HUMAN
A:
[11-300]
-------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
-------------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
----------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
---
Q
A
F
H
---
S
A
-
Q
P
I
E
K
F
V
---
T
---
D
I
--
D
E
L
---
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
525
Blastp_CBE
58.46
43%
-11
- C1 -
-
5L2I
1
CDK6_HUMAN
A:
[10-300]
------------------------------------------------------------------------------------------------------------------------------------
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
------------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
----------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
---
Q
A
F
--
K
-
S
A
-
Q
P
I
E
K
F
V
---
T
---
D
I
--
D
E
L
---
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
342
Blastp_CBE
57.61
51%
-10
- C1 -
-
4RJ3
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
L
D
-
T
-
E
----------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
517
Blastp_CBE
56.26
43%
-19
- C1 -
-
4TTH
1
CDK6_HUMAN
B:
[15-303]
-----------------------------------------------------------------------------------------------------------------------------------------
C
V
A
E
I
G
E
----
K
V
F
K
A
R
D
L
K
N
-
G
R
F
V
A
L
K
R
V
R
V
-------
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
---------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
-
Q
M
----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
---------------------
P
I
E
K
F
--------
D
I
--
D
E
L
---
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
-----------------------------------------------
343
Blastp_CBE
55.22
51%
-16
- C1 -
-
1OIR
1
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
-----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
344
Blastp_CBE
55.18
51%
-19
- C1 -
-
1H01
3
CDK2_HUMAN
A:
[2-289]
------------------------------------------------------------------------------------------------------------------------------------
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
-----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
E
----
N
-
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
S
-
F
P
K
W
-
A
R
-
Q
D
F
S
K
V
V
---
P
---
P
L
--
D
--
E
D
-
G
R
-------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------
527
Blastp_CBE
55.17
43%
-7
- C1 -
-
4AUA
1
CDK6_HUMAN
A:
[11-300]
-------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
----------------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
----------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
-------------------
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
---
Q
A
F
H
S
K
-
S
A
-
Q
P
I
E
K
F
V
---
T
---
D
I
--
D
E
L
---
G
K
-------
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------