@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK15_HUMAN: (2021-11-22 )
MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLASYQKGHHPAQFSKCW
Atome Classification :
(508 SA)
.........10........20........30........40........50........60........70........80........90......-..100.......110.......120....-...130....-...-140........150.....---..160.......------170----.----..-----......180.......190--.-----.-.-.....200.........210.......220.......230.-.-.....240.......250..----.....260.......270.......280.......290...-....300.......310.......320.......330.--...-.....---340-........350---.-.--....---.360.......370.......380.......390.......400.......410.......420.......430...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
G
Q
E
L
C
A
K
TVQPG
C
S
C
Y
HCSEGGEAHSCRRSQPETTE
A
A
F
K
LTDLKEASCSMTSFHPRG
L
Q
A
A
R
A
Q
K
F
K
SKRPRSNSDCF
Q
E
E
D
L
R
Q
G
F
Q
W
R
KSLPF-GA
A
S
S
Y
L
N
L
E
K
LGEG
S
Y
A
T
V
Y
K
G
I
S
R
IN
G
-
Q
L
V
A
L
K
V
I
SM-NAE-E-GV
P
F
T
A
I
R
E
A
S
L
L
K
GLK---HA
N
I
V
L
L
H
D
I
IH------
T
------
K
----
E
T
-----
L
T
F
V
F
E
Y
M
H
T
D
L
A
Q
Y
M
S
Q---H-----P-G-GLHP
H
N
--
V
R
L
F
M
F
Q
L
L
R
G
L
A
Y
I
H
H
Q
H
V
L
H
RDLK
P
Q
N
L
L
I
S
-
H
-
L
GEL
K
L
A
D
FG
L
A
R
A
KSIPSQ----TYSS
E
V
V
T
L
W
YR
P
P
D
A
LLGATEYSSELDIWGA
G
C
I
F
I
E
MFQ-GQPLFP
G
V
S
N
I
L
E
Q
L
E
K
I
W
E
V
LGVPTEDTWPG
V
S
K--L--PNY-NPEWF---P-L-PTPR
S
L
H
V
V
W
N
---R-L--GRVP---
E
A
E
D
L
A
S
Q
M
L
KGFPRDR
V
S
A
Q
E
A
L
V
H
D
Y
F
S
A
L
P
S
Q
L
YQLPDEE
S
L
F
T
VSG
V
R
L
K
P
E
M
C
D
L
L
A
S
Y
QKGHHPAQFSKCW
21
Blastp_CBE
94.09
56%
-121
- C1 -
-
5G6V
3
CDK16_HUMAN
B:
[3-312]
------------------------------------------------------------------------------------------------------
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
-
N
L
V
A
L
K
E
I
R
L
-
E
H
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
----
K
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
-----
G
-
N
-
I
I
N
M
H
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
----------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
-
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
----
L
--
S
N
E
-
E
F
K
T
Y
---
N
-
Y
-
P
K
Y
R
A
E
A
L
L
S
H
---
A
-
P
--
R
L
D
S
---
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
---------------------
2
PsiBlast_PDB
93.19
55%
-110
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[3-312]
------------------------------------------------------------------------------------------------------
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
-
N
L
V
A
L
K
E
I
R
L
-
E
H
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
----
K
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
-----
G
-
N
-
I
I
N
M
H
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
-
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
----
L
--
S
N
E
-
E
F
K
T
Y
---
N
-
Y
-
P
K
Y
R
A
E
A
L
L
S
H
---
A
-
P
--
R
L
D
S
---
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
---------------------
1
PsiBlast_PDB
89.48
55%
-116
- C1 -
-
3MTL
-
CDK16_HUMAN
A:
[3-312]
------------------------------------------------------------------------------------------------------
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
-
N
L
V
A
L
K
E
I
R
L
---------
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
----
K
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
-----
G
-
N
-
I
I
N
M
H
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
----------------
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
-
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
----
L
--
S
N
E
-
E
F
K
T
Y
---
N
-
Y
-
P
K
Y
R
A
E
A
L
L
S
H
---
A
-
P
--
R
L
D
S
---
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
---------------------
550
HHSearch
88.73
55%
-119
- C1 -
-
3MTL
-
CDK16_HUMAN
A:
[2-307]
-----------------------------------------------------------------------------------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
-
N
L
V
A
L
K
E
I
R
L
---------
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
----
K
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
-----
G
-
N
-
I
I
N
M
H
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
----------------
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
-
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
--
N
--
E
E
F
-
K
T
Y
N
Y
---
P
-
K
-
Y
R
A
E
A
L
L
S
H
-----
A
-
P
--
R
L
D
S
---
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
--------------------------
552
HHSearch
85.61
55%
-66
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[2-311]
-----------------------------------------------------------------------------------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
-
N
L
V
A
L
K
E
I
R
L
-
E
H
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
----
K
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
-----
G
-
N
-
I
I
N
M
H
N
--
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
-
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
--
N
--
E
E
F
-
K
T
Y
N
Y
---------
P
K
Y
R
A
E
A
L
L
S--
H
A
P
--
R
L
D
S
---
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
----------------------
12
PsiBlast_PDB
81.65
52%
-75
- C1 -
-
1H4L
-
CDK5_HUMAN
A:
[4-287]
-------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
E
T
H
-
E
I
V
A
L
K
R
V
R
L
-
D
-----
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
----
K
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
A
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
--
L
--
P
D
Y
-
K
P
--
Y
---
P
-
M
Y
P
A
T
T
S
L
V
N
V
V
P
---
K
-
L
--
N
A
T
-----
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------
14
PsiBlast_PDB
81.30
50%
-95
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-285]
------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
-
G
-
E
T
F
A
L
K
K
I
R
L
----------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
----
K
R
-----
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
-
G
L
E
S
V
T
--
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
-
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
--
L
--
P
K
Y
-
D
P
N
F
T
VYE
P
-
L
-
P
W
E
S
F
L
K
------------
G
L
D
E
---
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-----------------------------------------------
395
Blastp_CBE
80.65
49%
-54
- C1 -
-
4EOS
1
CDK2_HUMAN
A:
[2-289]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
---
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
9
PsiBlast_PDB
80.59
52%
-75
- C1 -
-
1UNH
-
CDK5_HUMAN
A:
[4-287]
-------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
--
H
-
E
I
V
A
L
K
R
V
R
L
-
D
-----
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
----
K
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
--
L
--
P
D
Y
-
K
P
--
Y
---
P
-
M
Y
P
A
T
T
S
L
V
N
V
V
P
---
K
-
L
--
N
A
T
-----
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------
164
Blastp_CBE
80.48
50%
-60
- C1 -
-
2CLX
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
172
Blastp_CBE
80.24
50%
-65
- C1 -
-
2C5Y
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
28
Blastp_CBE
79.88
51%
-90
- C1 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-285]
------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
-
G
-
E
T
F
A
L
K
K
I
R
L
------------
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
----
K
R
-----
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
-
G
L
E
S
V
T
--
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
-
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
--
L
--
P
K
Y
-
D
P
N
F
T
VYE
P
-
L
-
P
W
E
S
F
L
K
------------
G
L
D
E
---
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-----------------------------------------------
421
Blastp_CBE
79.86
49%
-58
- C1 -
-
4EOO
1
CDK2_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
447
Blastp_CBE
79.81
49%
-57
- C1 -
-
4EOR
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
445
Blastp_CBE
79.76
50%
-63
- C1 -
-
4ERW
17
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
S
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
434
Blastp_CBE
79.68
50%
-58
- C1 -
-
1W8C
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
W
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
417
Blastp_CBE
79.68
49%
-58
- C1 -
-
2IW9
1
CDK2_HUMAN
A:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
108
Blastp_CBE
79.58
50%
-58
- C1 -
-
3NS9
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
124
Blastp_CBE
79.54
50%
-58
- C1 -
-
2XMY
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
22
Blastp_CBE
79.47
52%
-61
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[6-291]
-----------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
-
E
I
V
A
L
K
R
V
R
L
-----
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
-----------
K
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
----------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
--
L
--
P
D
Y
-
K
P
--
Y
---
P
-
M
Y
P
A
T
T
S
L
V
N
V
V
P
---
K
-
L
--
N
A
T
-----
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------
501
Blastp_CBE
79.21
49%
-53
- C1 -
-
4EOI
2
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
85
Blastp_CBE
79.20
50%
-62
- C1 -
-
4FKL
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
30
Blastp_CBE
79.18
49%
-55
- C1 -
-
5OSM
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
113
Blastp_CBE
79.17
50%
-61
- C1 -
-
3IGG
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
238
Blastp_CBE
79.14
50%
-65
- C1 -
-
1B39
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
206
Blastp_CBE
79.13
50%
-65
- C1 -
-
1PXK
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
497
Blastp_CBE
79.12
49%
-52
- C1 -
-
4EOK
1
CDK2_HUMAN
A:
[3-289]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
5
PsiBlast_PDB
78.85
51%
-32
- C1 -
-
4KRC
1
PHO85_YEAST
A:
[2-298]
--------------------------------------------------------------------------------------------------
S
S
S
S
Q
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
K
T
T
G
-
V
Y
V
A
L
K
E
V
K
L
-
D
S
E
-
E
-
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
I
H
------
T
------
E
----
N
K
-----
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
---
R
T----
P
-
R
-
G
L
E
L
N
L
--
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
-
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
--
L
--
P
K
Y
-
N
P
N
I
Q
---
Q
-
R
-
P
-
P
R
D
L
R
Q
V
L
Q
---
P
-
H
--
T
K
E
P
LDG
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
-----------------------------------------------
415
Blastp_CBE
78.82
49%
-52
- C1 -
-
4EOJ
1
CDK2_HUMAN
A:
[3-290]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
78
Blastp_CBE
78.73
50%
-64
- C1 -
-
4FKU
3
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
239
Blastp_CBE
78.66
50%
-64
- C1 -
-
1B38
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
31
Blastp_CBE
78.65
49%
-61
- C1 -
-
5OO3
1
CDK2_HUMAN
A:
[7-291]
-----------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
205
Blastp_CBE
78.62
50%
-64
- C1 -
-
1PXL
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
143
Blastp_CBE
78.60
50%
-59
- C1 -
-
2VTL
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
115
Blastp_CBE
78.54
50%
-61
- C1 -
-
3FZ1
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
92
Blastp_CBE
78.50
50%
-59
- C1 -
-
4EK4
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
154
Blastp_CBE
78.46
50%
-62
- C1 -
-
2R3R
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
169
Blastp_CBE
78.44
50%
-64
- C1 -
-
2C6I
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
433
Blastp_CBE
78.37
50%
-61
- C1 -
-
2R3I
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
193
Blastp_CBE
78.34
50%
-64
- C1 -
-
1Y8Y
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
220
Blastp_CBE
78.24
50%
-65
- C1 -
-
1H0W
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
192
Blastp_CBE
78.24
50%
-63
- C1 -
-
1Y91
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
263
Blastp_CBE
78.18
50%
-60
- C1 -
-
6Q4H
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
261
Blastp_CBE
78.16
50%
-57
- C1 -
-
6Q4K
3
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
149
Blastp_CBE
78.13
50%
-67
- C1 -
-
2UZO
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
426
Blastp_CBE
78.12
50%
-58
- C1 -
-
2R3P
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
140
Blastp_CBE
78.02
50%
-63
- C1 -
-
2VTO
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
84
Blastp_CBE
77.92
50%
-63
- C1 -
-
4FKO
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
234
Blastp_CBE
77.90
50%
-56
- C1 -
-
1E1V
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
165
Blastp_CBE
77.91
50%
-59
- C1 -
-
2C6O
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
60
Blastp_CBE
77.90
50%
-65
- C1 -
-
5IEX
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
58
Blastp_CBE
77.87
50%
-58
- C1 -
-
5JQ5
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
233
Blastp_CBE
77.81
50%
-55
- C1 -
-
1E1X
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
267
Blastp_CBE
77.82
50%
-57
- C1 -
-
6Q4B
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
167
Blastp_CBE
77.81
50%
-58
- C1 -
-
2C6L
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
223
Blastp_CBE
77.80
50%
-59
- C1 -
-
1H07
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
13
PsiBlast_PDB
77.79
48%
-31
- C1 -
-
3NIZ
1
?
A:
[15-311]
-----------------------------------------------------------------------------------------------
Y
F
Q
G
L
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
-
Q
G
-
R
I
V
A
L
K
R
I
R
--------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
---
H
P
N
I
V
S
L
I
D
V
I
H
------
S
------
E
----
R
C
-----
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
-----
K
-
T
-
G
L
Q
D
S
Q
--
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-------
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
D
-
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
--
L
--
P
L
W
-
K
Q
R
T
F
---
Q
-
V
-
F
E
K
K
P
----
W
S
---
S
-
I
IP
G
F
C
Q
---
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-----------------------------------------
427
Blastp_CBE
77.73
50%
-60
- C1 -
-
2R3O
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
131
Blastp_CBE
77.69
50%
-57
- C1 -
-
2W06
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
98
Blastp_CBE
77.59
50%
-66
- C1 -
-
3WBL
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
T
G
-
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
262
Blastp_CBE
77.54
50%
-63
- C1 -
-
6Q4J
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
7
PsiBlast_PDB
77.54
51%
-56
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[4-291]
---------------------------------------------------------------------------------------------------
G
S
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
-
E
I
V
A
L
K
R
-----------
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
-------------------
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
------
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
--
L
--
P
D
Y
-
K
P
--
Y
---
P
-
M
Y
P
A
T
T
S
L
V
N
V
V
P
---
K
-
L
--
N
A
T
-----
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------
29
Blastp_CBE
77.53
50%
-108
- C1 -
-
1V0P
1
CDC2H_PLAFK
B:
[3-285]
------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
-
G
-
E
T
F
A
L
K
-------------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------------------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
-
G
L
E
S
V
T
--
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
-----------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
-
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
--
L
--
P
K
Y
-
D
P
N
F
T
VYE
P
-
L
-
P
W
E
S
F
L
K
------------
G
L
D
E
---
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-----------------------------------------------
171
Blastp_CBE
77.51
50%
-59
- C1 -
-
2C68
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
109
Blastp_CBE
77.48
50%
-55
- C1 -
-
3LFS
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
222
Blastp_CBE
77.44
50%
-60
- C1 -
-
1H08
2
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
236
Blastp_CBE
77.41
50%
-61
- C1 -
-
1DI8
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
10
PsiBlast_PDB
77.40
52%
-22
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[4-287]
-------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
-
E
I
V
A
L
K
R
V
R
L
-
D
D
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
----
K
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
--
L
--
P
D
Y
-
K
P
--
Y
---
P
-
M
Y
P
A
T
T
S
L
V
N
V
V
P
---
K
-
L
--
N
A
T
-----
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------
508
Blastp_CBE
77.39
46%
-35
- C1 -
-
6GU2
1
CDK1_HUMAN
A:
[3-299]
------------------------------------------------------------------------------------------------
L
-
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
-
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
----
S
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
--
L
--
Q
D
Y
-
K
-
N
T
F
---
P
-
K
-
W
K
P
G
S
L
A
S
H
V
K
---
N
-
L
--
D
E
-----
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
D
N
Q
I
-----------------------------------------
61
Blastp_CBE
77.37
50%
-64
- C1 -
-
5IEV
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
189
Blastp_CBE
77.35
50%
-60
- C1 -
-
2A4L
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
--------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
215
Blastp_CBE
77.34
50%
-72
- C1 -
-
1KE6
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
168
Blastp_CBE
77.30
50%
-59
- C1 -
-
2C6K
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
268
Blastp_CBE
77.29
50%
-57
- C1 -
-
6Q4A
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
170
Blastp_CBE
77.24
50%
-61
- C1 -
-
2C69
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
110
Blastp_CBE
77.23
50%
-54
- C1 -
-
3LFQ
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
91
Blastp_CBE
77.22
50%
-58
- C1 -
-
4EK5
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
212
Blastp_CBE
77.15
50%
-69
- C1 -
-
1KE9
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
204
Blastp_CBE
77.15
50%
-58
- C1 -
-
1PXM
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
155
Blastp_CBE
77.13
50%
-57
- C1 -
-
2R3H
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
157
Blastp_CBE
77.09
50%
-60
- C1 -
-
2R3F
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
153
Blastp_CBE
77.09
50%
-67
- C1 -
-
2R64
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
444
Blastp_CBE
76.99
50%
-58
- C1 -
-
6Q3C
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
76
Blastp_CBE
76.99
50%
-69
- C1 -
-
4FKW
2
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
35
Blastp_CBE
76.95
49%
-61
- C1 -
-
5K4J
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
A
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
562
HHSearch
76.80
40%
-113
- C1 -
-
1UA2
1
CDK7_HUMAN
B:
[13-299]
--------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
-
Q
I
V
A
I
K
K
-----------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
----
S
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
-
V
L
T
P
S
H
--
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
-
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
--
L
--
P
D
Y
-
V
T
--
F
---
K
-
S
-
F
P
G
I
P
L
H
H
I
F
------
S
--
A
A
G
D
---
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
--------------------------------------------
556
HHSearch
76.87
49%
-26
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[2-290]
-----------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
-
E
I
V
A
L
K
R
V
R
L
-
D
D
D
-
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
----
K
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
--
L
--
P
D
Y
-
K
P
Y
P
----
M
-
Y
-
P
A
T
T
S
L
V
N
V
V
P
--------
K
L
N
A
---
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
C
--------------------------------------------
265
Blastp_CBE
76.80
50%
-58
- C1 -
-
6Q4D
6
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
237
Blastp_CBE
76.85
50%
-69
- C1 -
-
1CKP
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
87
Blastp_CBE
76.83
50%
-57
- C1 -
-
4FKI
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
266
Blastp_CBE
76.82
50%
-56
- C1 -
-
6Q4C
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
150
Blastp_CBE
76.80
50%
-65
- C1 -
-
2UZN
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
142
Blastp_CBE
76.78
50%
-58
- C1 -
-
2VTM
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
166
Blastp_CBE
76.75
50%
-59
- C1 -
-
2C6M
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
505
Blastp_CBE
76.66
46%
-36
- C1 -
-
6GU6
1
CDK1_HUMAN
A:
[6-296]
----------------------------------------------------------------------------------------------------
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
-
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
----
S
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
-------
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
--
L
--
Q
D
Y
-
K
-
N
T
F
---
P
-
K
-
W
K
P
G
S
L
A
S
H
V
K
---
N
-
L
--
D
E
-----
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
D
--------------------------------------------
112
Blastp_CBE
76.59
50%
-53
- C1 -
-
3LE6
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
101
Blastp_CBE
76.58
50%
-64
- C1 -
-
3ULI
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
59
Blastp_CBE
76.49
50%
-63
- C1 -
-
5IEY
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
195
Blastp_CBE
76.43
50%
-67
- C1 -
-
1W0X
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
512
Blastp_CBE
76.44
46%
-35
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[5-302]
---------------------------------------------------------------------------------------------------
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
-
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
----
S
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
--
L
--
Q
D
Y
-
K
-
N
T
F
---
P
-
K
-
W
K
P
G
S
L
A
S
H
V
K
---
N
-
L
--
D
E
-----
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
D
N
Q
I
K
K
M
--------------------------------------
136
Blastp_CBE
76.43
50%
-63
- C1 -
-
2VTS
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
221
Blastp_CBE
76.41
50%
-57
- C1 -
-
1H0V
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
137
Blastp_CBE
76.41
50%
-54
- C1 -
-
2VTR
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
57
Blastp_CBE
76.38
50%
-61
- C1 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
254
Blastp_CBE
76.35
49%
-20
- C1 -
-
1H1S
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
393
Blastp_CBE
76.36
49%
-58
- C1 -
-
5MHQ
1
?
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
134
Blastp_CBE
76.35
50%
-58
- C1 -
-
2VU3
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
----
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
148
Blastp_CBE
76.33
50%
-57
- C1 -
-
2V0D
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
8
PsiBlast_PDB
76.31
52%
-31
- C1 -
-
1UNG
1
CDK5_HUMAN
A:
[4-287]
-------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
E
T
H
-
E
I
V
A
L
K
R
V
R
L
-
D
D
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
----
K
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
--
L
--
P
D
Y
-
K
P
--
Y
---
P
-
M
Y
P
A
T
T
S
L
V
N
V
V
P
---
K
-
L
--
N
A
T
-----
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------
357
Blastp_CBE
76.30
50%
-61
- C1 -
-
6Q4G
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
229
Blastp_CBE
76.26
50%
-63
- C1 -
-
1FVT
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
358
Blastp_CBE
76.22
50%
-56
- C1 -
-
6Q4I
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
L
---
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
145
Blastp_CBE
76.18
50%
-67
- C1 -
-
2VTI
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
27
Blastp_CBE
76.12
52%
-67
- C1 -
-
1UNG
1
CDK5_HUMAN
B:
[4-287]
-------------------------------------------------------------------------------------------------------
Y
E
K
L
E
K
-------
T
V
F
K
A
--------
I
V
A
L
K
R
V
R
L
-
D
-----
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
----
K
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
--
L
--
P
D
Y
-
K
P
--
Y
---
P
-
M
Y
P
A
T
T
S
L
V
N
V
V
P
---
K
-
L
--
N
A
T
-----
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------
88
Blastp_CBE
76.09
50%
-56
- C1 -
-
4FKG
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
39
Blastp_CBE
76.06
49%
-21
- C1 -
-
2WPA
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
214
Blastp_CBE
76.02
50%
-66
- C1 -
-
1KE7
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
89
Blastp_CBE
75.98
50%
-59
- C1 -
-
4EK8
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
503
Blastp_CBE
75.83
49%
-17
- C1 -
-
2IW8
1
CDK2_HUMAN
A:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
133
Blastp_CBE
75.93
50%
-66
- C1 -
-
2VV9
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
49
Blastp_CBE
75.91
49%
-23
- C1 -
-
2BKZ
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
216
Blastp_CBE
75.89
50%
-68
- C1 -
-
1KE5
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
499
Blastp_CBE
75.88
49%
-17
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
82
Blastp_CBE
75.86
50%
-62
- C1 -
-
4FKQ
2
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
25
Blastp_CBE
75.83
52%
-69
- C1 -
-
3O0G
1
CDK5_HUMAN
B:
[6-287]
---------------------------------------------------------------------------------------------------------
K
L
E
K
I
-----
G
T
V
F
K
A
-------
E
I
V
A
L
K
R
V
R
----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
----
K
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
-
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
--
L
--
P
D
Y
-
K
P
--
Y
---
P
-
M
Y
P
A
T
T
S
L
V
N
V
V
P
---
K
-
L
--
N
A
T
-----
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------
255
Blastp_CBE
75.79
49%
-17
- C1 -
-
1H1R
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
513
Blastp_CBE
75.71
46%
-33
- C1 -
-
4Y72
1
CDK1_HUMAN
A:
[3-294]
------------------------------------------------------------------------------------------------
L
-
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
-
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
----
S
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
--
L
--
Q
D
Y
-
K
-
N
T
F
---
P
-
K
-
W
K
P
G
S
L
A
S
H
V
K
---
N
-
L
--
D
E
-----
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
----------------------------------------------
67
Blastp_CBE
75.81
50%
-63
- C1 -
-
5ANI
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
107
Blastp_CBE
75.79
50%
-69
- C1 -
-
3S2P
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
96
Blastp_CBE
75.77
50%
-71
- C1 -
-
4BGH
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
511
Blastp_CBE
75.71
46%
-33
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[3-294]
------------------------------------------------------------------------------------------------
L
-
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
-
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
----
S
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
--
L
--
Q
D
Y
-
K
-
N
T
F
---
P
-
K
-
W
K
P
G
S
L
A
S
H
V
K
---
N
-
L
--
D
E
-----
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
----------------------------------------------
408
Blastp_CBE
75.64
49%
-18
- C1 -
-
1OIU
1
CDK2_HUMAN
A:
[3-290]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
282
Blastp_CBE
75.55
50%
-61
- C1 -
-
3RPY
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
147
Blastp_CBE
75.54
50%
-65
- C1 -
-
2VTA
3
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
33
Blastp_CBE
75.53
49%
-64
- C1 -
-
3EZV
1
CDK2_HUMAN
A:
[3-288]
----------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
423
Blastp_CBE
75.52
49%
-18
- C1 -
-
4EOP
1
CDK2_HUMAN
A:
[2-289]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
410
Blastp_CBE
75.50
49%
-16
- C1 -
-
1OI9
1
CDK2_HUMAN
A:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
403
Blastp_CBE
75.48
49%
-16
- C1 -
-
4CFN
1
CDK2_HUMAN
C:
[3-290]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
191
Blastp_CBE
75.46
50%
-15
- C1 -
-
1YKR
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
156
Blastp_CBE
75.46
50%
-56
- C1 -
-
2R3G
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
498
Blastp_CBE
75.45
49%
-17
- C1 -
-
4EON
1
CDK2_HUMAN
C:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
259
Blastp_CBE
75.43
49%
-20
- C1 -
-
1H1P
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
253
Blastp_CBE
75.39
49%
-13
- C1 -
-
1H1S
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
213
Blastp_CBE
75.39
50%
-64
- C1 -
-
1KE8
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
146
Blastp_CBE
75.36
50%
-66
- C1 -
-
2VTH
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
494
Blastp_CBE
75.33
49%
-17
- C1 -
-
4EOL
1
CDK2_HUMAN
C:
[1-289]
------------------------------------------------------------------------------------------------
L
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
230
Blastp_CBE
75.32
50%
-22
- C1 -
-
1FIN
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
466
Blastp_CBE
75.21
49%
-21
- C1 -
-
2CCI
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
144
Blastp_CBE
75.29
50%
-62
- C1 -
-
2VTJ
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
139
Blastp_CBE
75.28
50%
-58
- C1 -
-
2VTP
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
264
Blastp_CBE
75.27
50%
-62
- C1 -
-
6Q4E
3
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
391
Blastp_CBE
75.20
49%
-18
- C1 -
-
4BCM
1
CDK2_HUMAN
C:
[3-289]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
339
Blastp_CBE
75.20
50%
-60
- C1 -
-
3QTR
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
260
Blastp_CBE
75.24
49%
-20
- C1 -
-
1H1P
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
297
Blastp_CBE
75.20
50%
-63
- C1 -
-
3RAK
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
257
Blastp_CBE
75.23
49%
-19
- C1 -
-
1H1Q
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
114
Blastp_CBE
75.21
50%
-63
- C1 -
-
3IG7
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
284
Blastp_CBE
75.17
50%
-63
- C1 -
-
3RPR
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
242
Blastp_CBE
75.20
49%
-19
- C1 -
-
5NEV
1
?
C:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
470
Blastp_CBE
75.11
49%
-15
- C1 -
-
1QMZ
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
245
Blastp_CBE
75.19
49%
-16
- C1 -
-
5CYI
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
77
Blastp_CBE
75.17
50%
-62
- C1 -
-
4FKV
2
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
278
Blastp_CBE
75.15
50%
-64
- C1 -
-
3S1H
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
243
Blastp_CBE
75.13
49%
-18
- C1 -
-
5NEV
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
500
Blastp_CBE
75.01
49%
-19
- C1 -
-
4EOI
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
197
Blastp_CBE
75.11
50%
-69
- C1 -
-
1V1K
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
467
Blastp_CBE
75.09
49%
-19
- C1 -
-
2CCI
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
37
Blastp_CBE
75.05
49%
-21
- C1 -
-
2WXV
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
429
Blastp_CBE
75.04
50%
-62
- C1 -
-
2R3M
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
468
Blastp_CBE
75.02
49%
-19
- C1 -
-
2CCH
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
105
Blastp_CBE
75.01
50%
-65
- C1 -
-
3SW7
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
178
Blastp_CBE
75.00
50%
-20
- C1 -
-
2C5O
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
45
Blastp_CBE
74.99
49%
-18
- C1 -
-
2C4G
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
404
Blastp_CBE
74.92
49%
-16
- C1 -
-
4CFN
1
CDK2_HUMAN
A:
[3-290]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
256
Blastp_CBE
74.94
49%
-13
- C1 -
-
1H1R
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
430
Blastp_CBE
74.95
50%
-66
- C1 -
-
2R3L
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
181
Blastp_CBE
74.94
50%
-69
- C1 -
-
2BTS
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
425
Blastp_CBE
74.93
50%
-56
- C1 -
-
2R3Q
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
79
Blastp_CBE
74.92
50%
-58
- C1 -
-
4FKT
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
479
Blastp_CBE
74.90
50%
-17
- C1 -
-
2UZL
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
47
Blastp_CBE
74.89
49%
-19
- C1 -
-
2BPM
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
51
Blastp_CBE
74.86
49%
-22
- C1 -
-
1VYW
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
457
Blastp_CBE
74.76
49%
-15
- C1 -
-
5L2W
2
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
438
Blastp_CBE
74.76
49%
-16
- C1 -
-
3QHR
2
CDK2_HUMAN
C:
[1-288]
--------------------------------------------------------------------------------------------------
G
H
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
380
Blastp_CBE
74.83
49%
-22
- C1 -
-
3TNW
1
CDK2_HUMAN
A:
[2-288]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
235
Blastp_CBE
74.80
50%
-66
- C1 -
-
1DM2
5
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
65
Blastp_CBE
74.81
50%
-66
- C1 -
-
5ANK
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
-------------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
81
Blastp_CBE
74.80
50%
-61
- C1 -
-
4FKR
2
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
469
Blastp_CBE
74.79
49%
-22
- C1 -
-
2CCH
3
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
456
Blastp_CBE
74.70
49%
-19
- C1 -
-
5LMK
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
362
Blastp_CBE
74.72
50%
-65
- C1 -
-
1GII
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
338
Blastp_CBE
74.72
50%
-61
- C1 -
-
3QTS
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
97
Blastp_CBE
74.76
50%
-59
- C1 -
-
4ACM
3
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
496
Blastp_CBE
74.66
49%
-14
- C1 -
-
4EOK
1
CDK2_HUMAN
C:
[1-289]
------------------------------------------------------------------------------------------------
L
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
83
Blastp_CBE
74.76
50%
-63
- C1 -
-
4FKP
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
43
Blastp_CBE
74.75
49%
-17
- C1 -
-
2WIH
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
442
Blastp_CBE
74.67
50%
-54
- C1 -
-
6Q4F
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
248
Blastp_CBE
74.72
49%
-15
- C1 -
-
4CFW
1
CDK2_HUMAN
C:
[4-291]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
80
Blastp_CBE
74.74
50%
-65
- C1 -
-
4FKS
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
271
Blastp_CBE
74.73
50%
-61
- C1 -
-
6Q3B
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
86
Blastp_CBE
74.72
50%
-63
- C1 -
-
4FKJ
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
106
Blastp_CBE
74.70
50%
-63
- C1 -
-
3SW4
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
48
Blastp_CBE
74.70
49%
-25
- C1 -
-
2BKZ
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
432
Blastp_CBE
74.61
50%
-63
- C1 -
-
2R3J
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
130
Blastp_CBE
74.67
50%
-68
- C1 -
-
2W17
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
-----
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
364
Blastp_CBE
74.66
49%
-18
- C1 -
-
4CFV
1
CDK2_HUMAN
A:
[3-291]
------------------------------------------------------------------------------------------------
P
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
314
Blastp_CBE
74.61
50%
-59
- C1 -
-
3R7I
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
246
Blastp_CBE
74.65
49%
-16
- C1 -
-
4CFX
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
161
Blastp_CBE
74.64
50%
-58
- C1 -
-
2FVD
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------------
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
95
Blastp_CBE
74.64
50%
-65
- C1 -
-
4BZD
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
132
Blastp_CBE
74.63
50%
-65
- C1 -
-
2W05
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
419
Blastp_CBE
74.56
49%
-20
- C1 -
-
2IW6
1
CDK2_HUMAN
A:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
313
Blastp_CBE
74.61
50%
-60
- C1 -
-
3R7U
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
247
Blastp_CBE
74.60
49%
-20
- C1 -
-
4CFX
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
70
Blastp_CBE
74.57
50%
-67
- C1 -
-
5AND
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
158
Blastp_CBE
74.56
50%
-64
- C1 -
-
2J9M
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
299
Blastp_CBE
74.48
50%
-62
- C1 -
-
3RAH
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
463
Blastp_CBE
74.51
49%
-12
- C1 -
-
3DDP
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
495
Blastp_CBE
74.50
49%
-15
- C1 -
-
4EOL
1
CDK2_HUMAN
A:
[3-289]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
------L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
471
Blastp_CBE
74.41
49%
-16
- C1 -
-
1QMZ
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
382
Blastp_CBE
74.49
49%
-18
- C1 -
-
3MY5
3
CDK2_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
270
Blastp_CBE
74.48
50%
-60
- C1 -
-
6Q48
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
431
Blastp_CBE
74.47
50%
-65
- C1 -
-
2R3K
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
399
Blastp_CBE
74.45
49%
-19
- C1 -
-
6GUC
1
CDK2_HUMAN
C:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
384
Blastp_CBE
74.44
49%
-17
- C1 -
-
3BHV
2
CDK2_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
199
Blastp_CBE
74.41
50%
-67
- C1 -
-
1R78
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
258
Blastp_CBE
74.39
49%
-17
- C1 -
-
1H1Q
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
249
Blastp_CBE
74.34
49%
-21
- C1 -
-
4CFW
1
CDK2_HUMAN
A:
[4-291]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
244
Blastp_CBE
74.34
49%
-14
- C1 -
-
5CYI
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
73
Blastp_CBE
74.36
50%
-12
- C1 -
-
4KD1
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
176
Blastp_CBE
74.35
50%
-22
- C1 -
-
2C5V
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
180
Blastp_CBE
74.34
50%
-24
- C1 -
-
2C5N
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
461
Blastp_CBE
74.25
49%
-18
- C1 -
-
3DDQ
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
301
Blastp_CBE
74.33
50%
-61
- C1 -
-
3R9N
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
251
Blastp_CBE
74.32
49%
-15
- C1 -
-
4CFM
1
CDK2_HUMAN
A:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
418
Blastp_CBE
74.23
49%
-18
- C1 -
-
2IW6
1
CDK2_HUMAN
C:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
484
Blastp_CBE
74.20
50%
-23
- C1 -
-
2UZB
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
296
Blastp_CBE
74.29
50%
-63
- C1 -
-
3RAL
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
436
Blastp_CBE
74.20
49%
-14
- C1 -
-
3QHW
3
CDK2_HUMAN
C:
[1-288]
--------------------------------------------------------------------------------------------------
G
H
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
455
Blastp_CBE
74.19
49%
-18
- C1 -
-
6GVA
3
CDK2_HUMAN
A:
[2-287]
----------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
366
Blastp_CBE
74.25
49%
-15
- C1 -
-
4CFU
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
P
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
378
Blastp_CBE
74.19
49%
-14
- C1 -
-
4BCK
2
CDK2_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
485
Blastp_CBE
74.15
50%
-17
- C1 -
-
2UZB
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
34
Blastp_CBE
74.24
49%
-60
- C1 -
-
3EZR
2
CDK2_HUMAN
A:
[3-288]
----------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
183
Blastp_CBE
74.23
50%
-66
- C1 -
-
2BHH
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
478
Blastp_CBE
74.22
50%
-16
- C1 -
-
2UZL
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
477
Blastp_CBE
74.12
50%
-17
- C1 -
-
4II5
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
272
Blastp_CBE
74.21
50%
-60
- C1 -
-
6GUK
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
374
Blastp_CBE
74.20
49%
-14
- C1 -
-
4BCO
1
CDK2_HUMAN
A:
[2-288]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
50
Blastp_CBE
74.19
49%
-21
- C1 -
-
1VYW
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
402
Blastp_CBE
74.17
49%
-18
- C1 -
-
6GUB
1
CDK2_HUMAN
A:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
388
Blastp_CBE
74.15
49%
-20
- C1 -
-
3BHT
1
CDK2_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
506
Blastp_CBE
74.14
46%
-33
- C1 -
-
6GU4
1
CDK1_HUMAN
A:
[3-294]
------------------------------------------------------------------------------------------------
L
-
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
-
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
----
S
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
--
L
--
Q
D
Y
-
K
-
N
T
F
---
P
-
K
-
W
K
P
G
S
L
A
S
H
V
K
---
N
-
L
--
D
E
-----
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
----------------------------------------------
41
Blastp_CBE
74.13
49%
-22
- C1 -
-
2WIP
1
CDK2_HUMAN
A:
[2-291]
-----------------------------------------------------------------------------------------------
P
L
-
V
D
M
E
N
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
273
Blastp_CBE
74.12
50%
-55
- C1 -
-
6GUH
3
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
397
Blastp_CBE
74.11
49%
-17
- C1 -
-
6GUF
1
CDK2_HUMAN
A:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
152
Blastp_CBE
74.09
50%
-20
- C1 -
-
2UUE
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
116
Blastp_CBE
74.09
50%
-20
- C1 -
-
3F5X
2
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
452
Blastp_CBE
74.01
49%
-18
- C1 -
-
1E9H
1
CDK2_HUMAN
A:
[2-287]
----------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
372
Blastp_CBE
74.07
49%
-14
- C1 -
-
4BCP
1
CDK2_HUMAN
A:
[2-288]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
473
Blastp_CBE
73.98
49%
-23
- C1 -
-
1P5E
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
44
Blastp_CBE
74.06
49%
-19
- C1 -
-
2C4G
1
CDK2_HUMAN
C:
[4-291]
--------------------------------------------------------------------------------------------------
V
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
198
Blastp_CBE
74.05
50%
-72
- C1 -
-
1URW
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
38
Blastp_CBE
74.04
49%
-16
- C1 -
-
2WPA
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
451
Blastp_CBE
73.96
49%
-12
- C1 -
-
1E9H
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
225
Blastp_CBE
74.01
50%
-63
- C1 -
-
1GIH
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
151
Blastp_CBE
73.98
50%
-17
- C1 -
-
2UUE
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
482
Blastp_CBE
73.88
50%
-24
- C1 -
-
2UZD
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
476
Blastp_CBE
73.88
50%
-17
- C1 -
-
4II5
3
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
459
Blastp_CBE
73.88
49%
-18
- C1 -
-
3DOG
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
--
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
179
Blastp_CBE
73.96
50%
-15
- C1 -
-
2C5N
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
392
Blastp_CBE
73.89
49%
-18
- C1 -
-
4BCM
1
CDK2_HUMAN
A:
[2-289]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
54
Blastp_CBE
73.95
49%
-23
- C1 -
-
4EOQ
1
CDK2_HUMAN
A:
[3-290]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
138
Blastp_CBE
73.94
50%
-63
- C1 -
-
2VTQ
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
424
Blastp_CBE
73.87
50%
-59
- C1 -
-
4NJ3
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
288
Blastp_CBE
73.92
50%
-60
- C1 -
-
3RMF
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
42
Blastp_CBE
73.91
49%
-21
- C1 -
-
2WIH
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
412
Blastp_CBE
73.90
49%
-16
- C1 -
-
1OGU
1
CDK2_HUMAN
A:
[3-290]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
125
Blastp_CBE
73.89
50%
-15
- C1 -
-
2X1N
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
74
Blastp_CBE
73.88
50%
-18
- C1 -
-
4FX3
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
224
Blastp_CBE
73.87
50%
-61
- C1 -
-
1H00
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
437
Blastp_CBE
73.79
49%
-14
- C1 -
-
3QHW
2
CDK2_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------
G
H
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
409
Blastp_CBE
73.79
49%
-14
- C1 -
-
1OI9
1
CDK2_HUMAN
C:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
240
Blastp_CBE
73.83
50%
-59
- C1 -
-
1AQ1
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
227
Blastp_CBE
73.83
50%
-20
- C1 -
-
1FVV
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
377
Blastp_CBE
73.77
49%
-20
- C1 -
-
4BCK
1
CDK2_HUMAN
C:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
376
Blastp_CBE
73.77
49%
-19
- C1 -
-
4BCN
1
CDK2_HUMAN
A:
[2-288]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
465
Blastp_CBE
73.81
49%
-16
- C1 -
-
2G9X
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
317
Blastp_CBE
73.79
50%
-12
- C1 -
-
3R71
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
128
Blastp_CBE
73.77
50%
-19
- C1 -
-
2WEV
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
375
Blastp_CBE
73.76
49%
-17
- C1 -
-
4BCN
1
CDK2_HUMAN
C:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
488
Blastp_CBE
73.65
50%
-16
- C1 -
-
2C6T
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
119
Blastp_CBE
73.74
50%
-23
- C1 -
-
3EOC
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
483
Blastp_CBE
73.73
50%
-15
- C1 -
-
2UZD
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
159
Blastp_CBE
73.71
50%
-21
- C1 -
-
2I40
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
454
Blastp_CBE
73.68
50%
-13
- C1 -
-
4I3Z
4
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
300
Blastp_CBE
73.63
50%
-57
- C1 -
-
3R9O
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
422
Blastp_CBE
73.67
49%
-14
- C1 -
-
4EOP
1
CDK2_HUMAN
C:
[3-289]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
406
Blastp_CBE
73.66
49%
-15
- C1 -
-
1OIY
1
CDK2_HUMAN
A:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
118
Blastp_CBE
73.65
50%
-23
- C1 -
-
3EOC
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
36
Blastp_CBE
73.65
49%
-18
- C1 -
-
2WXV
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
208
Blastp_CBE
73.64
50%
-11
- C1 -
-
1PXI
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
177
Blastp_CBE
73.62
50%
-20
- C1 -
-
2C5O
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
141
Blastp_CBE
73.62
50%
-62
- C1 -
-
2VTN
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
394
Blastp_CBE
73.60
49%
-20
- C1 -
-
4EOS
1
CDK2_HUMAN
C:
[3-289]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
439
Blastp_CBE
73.56
49%
-16
- C1 -
-
3QHR
6
CDK2_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------
G
H
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
117
Blastp_CBE
73.47
50%
-24
- C1 -
-
3F5X
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
472
Blastp_CBE
73.46
49%
-15
- C1 -
-
1P5E
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
185
Blastp_CBE
73.44
50%
-61
- C1 -
-
2B55
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
475
Blastp_CBE
73.34
49%
-13
- C1 -
-
1GY3
1
CDK2_HUMAN
A:
[2-287]
----------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
489
Blastp_CBE
73.31
50%
-13
- C1 -
-
2C6T
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
386
Blastp_CBE
73.32
49%
-16
- C1 -
-
3BHU
1
CDK2_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
441
Blastp_CBE
73.36
49%
-20
- C1 -
-
4EOM
1
CDK2_HUMAN
A:
[3-290]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
---
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
294
Blastp_CBE
73.31
50%
-9
- C1 -
-
3RK5
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
94
Blastp_CBE
73.34
50%
-60
- C1 -
-
4D1X
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
348
Blastp_CBE
73.33
50%
-14
- C1 -
-
3QQF
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
162
Blastp_CBE
73.32
50%
-10
- C1 -
-
2EXM
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
66
Blastp_CBE
73.31
50%
-15
- C1 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
507
Blastp_CBE
73.20
46%
-31
- C1 -
-
6GU3
1
CDK1_HUMAN
A:
[3-294]
------------------------------------------------------------------------------------------------
L
-
G
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
-
Q
V
V
A
M
K
K
I
R
L
-
E
S
E
-
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
----
S
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
-----
P
-
P
-
G
Q
Y
M
D
S
SL
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
--
L
--
Q
D
Y
-
K
-
N
T
F
---
P
-
K
-
W
K
P
G
S
L
A
S
H
V
K
---
N
-
L
--
D
E
-----
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
----------------------------------------------
341
Blastp_CBE
73.24
50%
-13
- C1 -
-
3QRU
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
450
Blastp_CBE
73.29
49%
-20
- C1 -
-
1PKD
1
CDK2_HUMAN
A:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
289
Blastp_CBE
73.24
50%
-11
- C1 -
-
3RM7
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
492
Blastp_CBE
73.16
50%
-14
- C1 -
-
1JST
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
480
Blastp_CBE
73.25
50%
-16
- C1 -
-
2UZE
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
209
Blastp_CBE
73.24
50%
-15
- C1 -
-
1PF8
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
226
Blastp_CBE
73.23
50%
-67
- C1 -
-
1G5S
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
307
Blastp_CBE
73.18
50%
-11
- C1 -
-
3R8P
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
481
Blastp_CBE
73.13
50%
-19
- C1 -
-
2UZE
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
90
Blastp_CBE
73.20
50%
-59
- C1 -
-
4EK6
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
123
Blastp_CBE
73.19
50%
-11
- C1 -
-
2XNB
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
292
Blastp_CBE
73.18
50%
-11
- C1 -
-
3RK9
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
231
Blastp_CBE
73.17
50%
-14
- C1 -
-
1FIN
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
320
Blastp_CBE
73.16
50%
-11
- C1 -
-
3R1Y
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
405
Blastp_CBE
73.15
49%
-14
- C1 -
-
1OIY
1
CDK2_HUMAN
C:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
420
Blastp_CBE
73.07
49%
-16
- C1 -
-
4EOO
1
CDK2_HUMAN
C:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
379
Blastp_CBE
73.13
49%
-14
- C1 -
-
3TNW
1
CDK2_HUMAN
C:
[3-288]
----------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
46
Blastp_CBE
73.07
49%
-17
- C1 -
-
2BPM
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
52
Blastp_CBE
73.06
49%
-65
- C1 -
-
6INL
1
?
A:
[2-287]
----------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
18
PsiBlast_PDB
73.06
50%
-29
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[3-285]
------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
-
G
-
E
T
F
A
L
K
K
I
R
L
-
E
K
E
D
E
-
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
----
K
R
-----
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
-----
E
-
G
-
G
L
E
S
V
T
--
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
-------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
-
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
--
L
--
P
K
Y
-
D
P
N
F
T
VYE
P
-
L
-
P
W
E
S
F
L
K
------------
G
L
D
E
---
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-----------------------------------------------
361
Blastp_CBE
73.05
50%
-60
- C1 -
-
1GIJ
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
286
Blastp_CBE
73.01
50%
-13
- C1 -
-
3ROY
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
517
Blastp_CBE
73.04
41%
-79
- C1 -
-
1UA2
1
CDK7_HUMAN
B:
[13-299]
--------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
-
Q
I
V
A
I
K
K
-----------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
----
S
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
-
V
L
T
P
S
H
--
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
-
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
--
L
--
P
D
Y
V
T
F
K
S
F
---
P
G
I
-
P
----
L
H
H
I
F
S
---
A
-
A
--
G
D
-----
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
--------------------------------------------
449
Blastp_CBE
73.03
49%
-16
- C1 -
-
1PKD
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
196
Blastp_CBE
73.01
50%
-56
- C1 -
-
1VYZ
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
274
Blastp_CBE
73.00
50%
-15
- C1 -
-
4GCJ
5
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
453
Blastp_CBE
72.90
50%
-12
- C1 -
-
4I3Z
3
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
163
Blastp_CBE
72.95
50%
-62
- C1 -
-
2DUV
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
---------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
330
Blastp_CBE
72.88
50%
-13
- C1 -
-
3QX2
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
329
Blastp_CBE
72.92
50%
-12
- C1 -
-
3QX4
3
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
389
Blastp_CBE
72.86
49%
-17
- C1 -
-
4BCQ
1
CDK2_HUMAN
C:
[3-289]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
343
Blastp_CBE
72.90
50%
-11
- C1 -
-
3QQL
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
69
Blastp_CBE
72.88
50%
-13
- C1 -
-
5ANE
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
281
Blastp_CBE
72.87
50%
-57
- C1 -
-
3RZB
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
322
Blastp_CBE
72.86
50%
-11
- C1 -
-
3R1Q
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
120
Blastp_CBE
72.85
50%
-15
- C1 -
-
3EJ1
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
203
Blastp_CBE
72.82
50%
-10
- C1 -
-
1PXN
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
121
Blastp_CBE
72.77
50%
-18
- C1 -
-
3EJ1
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
190
Blastp_CBE
72.74
50%
-10
- C1 -
-
2A0C
1
CDK2_HUMAN
X:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
285
Blastp_CBE
72.75
50%
-13
- C1 -
-
3RPO
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
122
Blastp_CBE
72.74
50%
-17
- C1 -
-
3EID
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
327
Blastp_CBE
72.68
50%
-12
- C1 -
-
3QXP
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
186
Blastp_CBE
72.71
50%
-12
- C1 -
-
2B54
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
309
Blastp_CBE
72.68
50%
-11
- C1 -
-
3R8L
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
40
Blastp_CBE
72.66
49%
-23
- C1 -
-
2WIP
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
D
M
E
N
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
321
Blastp_CBE
72.64
50%
-10
- C1 -
-
3R1S
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
311
Blastp_CBE
72.63
50%
-11
- C1 -
-
3R7Y
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
298
Blastp_CBE
72.61
50%
-13
- C1 -
-
3RAI
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
310
Blastp_CBE
72.60
50%
-12
- C1 -
-
3R83
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
347
Blastp_CBE
72.53
50%
-11
- C1 -
-
3QQG
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
331
Blastp_CBE
72.58
50%
-12
- C1 -
-
3QWK
5
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
316
Blastp_CBE
72.56
50%
-13
- C1 -
-
3R73
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
127
Blastp_CBE
72.54
50%
-16
- C1 -
-
2WEV
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
4
PsiBlast_PDB
72.54
51%
-35
- C1 -
-
2PMI
2
PHO85_YEAST
A:
[19-298]
-------------------------------------------------------------------------------------------------------------------
A
T
V
Y
K
G
L
N
K
T
T
G
-
V
Y
V
A
L
K
E
V
K
L
-
D
S
E
-
E
-
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
I
H
------
T
------
E
----
N
K
-----
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
---
R
TVGNT
P
-
R
-
G
L
E
L
N
L
--
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
-
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
--
L
--
P
K
Y
-
N
P
N
I
Q
---
Q
-
R
-
P
-
P
R
D
L
R
Q
V
L
Q
---
P
-
H
--
T
K
E
P
LDG
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
-----------------------------------------------
126
Blastp_CBE
72.53
50%
-17
- C1 -
-
2X1N
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
102
Blastp_CBE
72.52
50%
-12
- C1 -
-
3TIZ
9
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
462
Blastp_CBE
72.49
49%
-19
- C1 -
-
3DDP
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
353
Blastp_CBE
72.48
50%
-11
- C1 -
-
3PXY
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
334
Blastp_CBE
72.41
50%
-13
- C1 -
-
3QTZ
3
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
160
Blastp_CBE
72.45
50%
-23
- C1 -
-
2I40
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
306
Blastp_CBE
72.41
50%
-13
- C1 -
-
3R8U
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
323
Blastp_CBE
72.39
50%
-11
- C1 -
-
3QZI
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
325
Blastp_CBE
72.34
50%
-12
- C1 -
-
3QZG
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
400
Blastp_CBE
72.30
49%
-18
- C1 -
-
6GUC
1
CDK2_HUMAN
A:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
340
Blastp_CBE
72.29
50%
-11
- C1 -
-
3QTQ
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
396
Blastp_CBE
72.28
49%
-14
- C1 -
-
6GUF
1
CDK2_HUMAN
C:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
413
Blastp_CBE
72.17
49%
-16
- C1 -
-
6GUE
1
CDK2_HUMAN
A:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
N
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
474
Blastp_CBE
72.23
49%
-19
- C1 -
-
1GY3
2
CDK2_HUMAN
C:
[2-287]
----------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
135
Blastp_CBE
72.22
50%
-59
- C1 -
-
2VTT
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
326
Blastp_CBE
72.17
50%
-12
- C1 -
-
3QZF
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
283
Blastp_CBE
72.16
50%
-11
- C1 -
-
3RPV
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
319
Blastp_CBE
72.15
50%
-11
- C1 -
-
3R28
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
201
Blastp_CBE
72.14
50%
-8
- C1 -
-
1PXP
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
302
Blastp_CBE
72.01
50%
-13
- C1 -
-
3R9H
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
345
Blastp_CBE
72.05
50%
-12
- C1 -
-
3QQJ
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
71
Blastp_CBE
72.03
50%
-24
- C1 -
-
5A14
2
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
--T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
182
Blastp_CBE
72.01
50%
-60
- C1 -
-
2BTR
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
344
Blastp_CBE
72.00
50%
-15
- C1 -
-
3QQK
6
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
359
Blastp_CBE
71.94
49%
-67
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
332
Blastp_CBE
71.96
50%
-13
- C1 -
-
3QWJ
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
207
Blastp_CBE
71.94
50%
-9
- C1 -
-
1PXJ
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
75
Blastp_CBE
71.94
50%
-15
- C1 -
-
4FX3
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
342
Blastp_CBE
71.93
50%
-11
- C1 -
-
3QRT
3
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
276
Blastp_CBE
71.90
50%
-13
- C1 -
-
4EZ3
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
202
Blastp_CBE
71.88
50%
-12
- C1 -
-
1PXO
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
103
Blastp_CBE
71.84
50%
-14
- C1 -
-
3TIY
12
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
315
Blastp_CBE
71.83
50%
-8
- C1 -
-
3R7E
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
275
Blastp_CBE
71.82
50%
-9
- C1 -
-
4EZ7
7
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
291
Blastp_CBE
71.78
50%
-13
- C1 -
-
3RKB
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
557
HHSearch
71.81
50%
-31
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[6-293]
-----------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
-
E
I
V
A
L
K
R
V
R
L
------E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
-----------
K
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
-----
N
-
G
-
D
L
D
P
E
I
--
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
----------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
--
L
--
P
D
Y
-
K
P
Y
P
M
-----
Y
-
P
A
T
T
S
L
V
N
V
V
------
P
--
K
L
N
A
---
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
---------------------------------------------
175
Blastp_CBE
71.80
50%
-17
- C1 -
-
2C5V
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
99
Blastp_CBE
71.78
50%
-12
- C1 -
-
3UNK
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
324
Blastp_CBE
71.77
50%
-9
- C1 -
-
3QZH
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
228
Blastp_CBE
71.75
50%
-16
- C1 -
-
1FVV
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
355
Blastp_CBE
71.73
50%
-12
- C1 -
-
3PXQ
4
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
219
Blastp_CBE
71.72
50%
-9
- C1 -
-
1HCK
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
287
Blastp_CBE
71.70
50%
-10
- C1 -
-
3RNI
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
491
Blastp_CBE
71.57
50%
-16
- C1 -
-
1JST
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
312
Blastp_CBE
71.65
50%
-10
- C1 -
-
3R7V
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
493
Blastp_CBE
71.53
50%
-17
- C1 -
-
1FQ1
1
CDK2_HUMAN
B:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
280
Blastp_CBE
71.62
50%
-11
- C1 -
-
3S00
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
349
Blastp_CBE
71.61
50%
-10
- C1 -
-
3QL8
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
295
Blastp_CBE
71.57
50%
-10
- C1 -
-
3RJC
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
318
Blastp_CBE
71.55
50%
-12
- C1 -
-
3R6X
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
336
Blastp_CBE
71.50
50%
-12
- C1 -
-
3QTW
6
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
293
Blastp_CBE
71.54
50%
-8
- C1 -
-
3RK7
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
346
Blastp_CBE
71.53
50%
-10
- C1 -
-
3QQH
4
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
333
Blastp_CBE
71.52
50%
-12
- C1 -
-
3QU0
5
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
305
Blastp_CBE
71.50
50%
-12
- C1 -
-
3R8V
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
350
Blastp_CBE
71.36
50%
-3
- C1 -
-
3PY1
4
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
104
Blastp_CBE
71.33
50%
-12
- C1 -
-
3TI1
8
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
401
Blastp_CBE
71.32
49%
-14
- C1 -
-
6GUB
1
?
C:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
----------
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
303
Blastp_CBE
71.28
50%
-10
- C1 -
-
3R9D
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
352
Blastp_CBE
71.25
50%
-5
- C1 -
-
3PXZ
3
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
356
Blastp_CBE
71.22
50%
-4
- C1 -
-
3PXF
7
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
194
Blastp_CBE
71.21
50%
-17
- C1 -
-
1WCC
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
328
Blastp_CBE
71.16
50%
-12
- C1 -
-
3QXO
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
390
Blastp_CBE
71.13
49%
-13
- C1 -
-
4BCQ
1
CDK2_HUMAN
A:
[2-289]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
174
Blastp_CBE
71.06
50%
-12
- C1 -
-
2C5X
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
100
Blastp_CBE
71.06
50%
-12
- C1 -
-
3UNJ
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
187
Blastp_CBE
71.05
50%
-7
- C1 -
-
2B53
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
337
Blastp_CBE
71.03
50%
-11
- C1 -
-
3QTU
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
335
Blastp_CBE
70.94
50%
-10
- C1 -
-
3QTX
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
304
Blastp_CBE
70.91
50%
-12
- C1 -
-
3R8Z
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
--------
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
72
Blastp_CBE
70.90
50%
-14
- C1 -
-
4LYN
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
351
Blastp_CBE
70.74
50%
-11
- C1 -
-
3PY0
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
200
Blastp_CBE
70.70
50%
-71
- C1 -
-
1PYE
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
-----------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
63
Blastp_CBE
70.61
50%
-61
- C1 -
-
5FP5
3
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
398
Blastp_CBE
70.58
49%
-18
- C1 -
-
6GUE
1
CDK2_HUMAN
C:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
-----
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-----
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
516
Blastp_CBE
70.57
41%
-71
- C1 -
-
1UA2
1
CDK7_HUMAN
C:
[13-299]
--------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
-
Q
I
V
A
I
K
K
-----------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
----
S
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
-
V
L
T
P
S
H
--
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
-
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
--
L
--
P
D
Y
V
T
F
K
S
F
---
P
G
I
-
P
----
L
H
H
I
F
S
---
A
-
A
--
G
D
-----
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
--------------------------------------------
290
Blastp_CBE
70.37
50%
-7
- C1 -
-
3RM6
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
68
Blastp_CBE
70.37
50%
-64
- C1 -
-
5ANG
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
279
Blastp_CBE
70.24
50%
-15
- C1 -
-
3S0O
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
173
Blastp_CBE
70.21
50%
-20
- C1 -
-
2C5X
1
CDK2_HUMAN
C:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
211
Blastp_CBE
70.03
50%
-69
- C1 -
-
1OIQ
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
241
Blastp_CBE
70.00
50%
-14
- C1 -
-
3PJ8
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
515
Blastp_CBE
69.64
41%
-76
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-299]
--------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
-
Q
I
V
A
I
K
K
-----------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
----
S
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
-
V
L
T
P
S
H
--
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
-
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
--
L
--
P
D
Y
V
T
F
K
S
F
---
P
G
I
-
P
----
L
H
H
I
F
S
---
A
-
A
--
G
D
-----
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
--------------------------------------------
210
Blastp_CBE
69.36
50%
-61
- C1 -
-
1P2A
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
277
Blastp_CBE
69.32
50%
-9
- C1 -
-
3SQQ
2
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
111
Blastp_CBE
69.32
50%
-5
- C1 -
-
3LFN
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
62
Blastp_CBE
69.15
50%
-15
- C1 -
-
5FP6
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
514
Blastp_CBE
68.93
47%
-21
- C1 -
-
3GC0
1
?
A:
[36-323]
-------------------------------------------------------------------------------------------------------
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
T
V
T
N
-
E
T
V
A
I
K
R
I
R
L
E
H
---------
T
A
I
R
E
V
S
L
L
K
E
L
Q
---
H
R
N
I
I
E
L
K
S
V
I
H
------
H
------
N
----
H
R
-----
L
H
L
I
F
E
Y
A
E
N
D
L
K
K
Y
M
D
K
---
N
-----
P
-
D
--
V
S
M
R
V
--
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
V
E
-
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
-------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
-
K
T
P
L
F
P
G
D
S
E
I
-
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
P
G
V
T
A
--
L
--
P
D
W
-
K
-
Q
S
F
---
P
-
K
-
F
R
G
K
T
L
K
R
V
L
G
---
A
-
L
--
L
D
D
----
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
S
-----------------------------------------------
64
Blastp_CBE
68.92
50%
-64
- C1 -
-
5D1J
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
----------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
32
Blastp_CBE
68.56
49%
-12
- C1 -
-
5OO1
1
CDK2_HUMAN
A:
[9-291]
-------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
129
Blastp_CBE
68.55
50%
-9
- C1 -
-
2W1H
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
518
Blastp_CBE
68.45
41%
-71
- C1 -
-
1UA2
1
CDK7_HUMAN
A:
[13-299]
--------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
-
Q
I
V
A
I
K
K
-----------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
----
S
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
-----
S
-
L
-
V
L
T
P
S
H
--
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
-
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
--
L
--
P
D
Y
V
T
F
K
S
F
---
P
G
I
-
P
----
L
H
H
I
F
S
---
A
-
A
--
G
D
-----
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
--------------------------------------------
428
Blastp_CBE
68.31
50%
-66
- C1 -
-
2R3N
1
CDK2_HUMAN
A:
[4-287]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
308
Blastp_CBE
68.18
50%
-11
- C1 -
-
3R8M
1
CDK2_HUMAN
A:
[11-294]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
93
Blastp_CBE
67.65
50%
-62
- C1 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
--------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
---------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
188
Blastp_CBE
66.78
50%
-6
- C1 -
-
2B52
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
250
Blastp_CBE
66.65
49%
-31
- C1 -
-
4CFM
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
414
Blastp_CBE
66.45
49%
-34
- C1 -
-
4EOJ
1
CDK2_HUMAN
C:
[1-290]
-----------------------------------------------------------------------------------------------
P
L
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
----------------------------
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
416
Blastp_CBE
66.09
49%
-30
- C1 -
-
2IW9
1
CDK2_HUMAN
C:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
558
HHSearch
65.61
36%
-31
- C1 -
-
4NM3
5
GSK3B_HUMAN
A:
[53-346]
----------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
-
E
L
V
A
I
K
K
V
L
Q
-
D
K
-------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
---
H
C
N
I
V
R
L
R
Y
F
F
Y
------
S
------
S
KKDE
V
Y
-----
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
YSR
A
-----
K
-
Q
-
T
L
P
V
I
Y
--
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
-
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
-
E
----
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
P
G
D
S
G
-
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
------
N
Y
-
T
E
--
F
---
K
-
F
---
P
Q
I
K
A
H
P
W
T
KVF
R
-
P
--
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
------------------------------------------
53
Blastp_CBE
65.24
49%
-35
- C1 -
-
4EOQ
1
CDK2_HUMAN
C:
[1-290]
-----------------------------------------------------------------------------------------------
P
L
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
407
Blastp_CBE
65.16
49%
-31
- C1 -
-
1OIU
1
CDK2_HUMAN
C:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
------------------------------------------
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
523
Blastp_CBE
64.82
40%
-20
- C1 -
-
1XO2
1
CDK6_HUMAN
B:
[11-303]
-----------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
------
S
------RETK-
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
-
Q
M
----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
--
L
--
P
R
----
Q
A
F
---
H
-----
A
Q
P
I
E
K
F
V
T
---
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
---------------------------------------------
365
Blastp_CBE
64.73
49%
-29
- C1 -
-
4CFU
1
CDK2_HUMAN
C:
[3-291]
------------------------------------------------------------------------------------------------
P
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------------
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
464
Blastp_CBE
64.63
49%
-27
- C1 -
-
2G9X
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
502
Blastp_CBE
64.56
49%
-32
- C1 -
-
2IW8
1
CDK2_HUMAN
C:
[4-290]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
------------------------------------------
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
373
Blastp_CBE
64.36
49%
-28
- C1 -
-
4BCO
1
CDK2_HUMAN
C:
[2-288]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
--------------------------------------
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
460
Blastp_CBE
64.25
49%
-28
- C1 -
-
3DDQ
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
------------------------------------------
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
446
Blastp_CBE
64.17
49%
-31
- C1 -
-
4EOR
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
440
Blastp_CBE
63.85
49%
-31
- C1 -
-
4EOM
1
CDK2_HUMAN
C:
[1-290]
-----------------------------------------------------------------------------------------------
P
L
-
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
383
Blastp_CBE
63.75
49%
-30
- C1 -
-
3BHV
1
CDK2_HUMAN
C:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------------
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
385
Blastp_CBE
63.58
49%
-27
- C1 -
-
3BHU
1
CDK2_HUMAN
C:
[1-288]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------------
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
387
Blastp_CBE
63.55
49%
-29
- C1 -
-
3BHT
1
CDK2_HUMAN
C:
[2-288]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------------
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
381
Blastp_CBE
63.45
49%
-30
- C1 -
-
3MY5
1
CDK2_HUMAN
C:
[2-288]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
-----------------------------------------
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
411
Blastp_CBE
63.43
49%
-28
- C1 -
-
1OGU
1
CDK2_HUMAN
C:
[3-290]
--------------------------------------------------------------------------------------------------
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------------
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
553
HHSearch
63.39
36%
-17
- C1 -
-
4IC7
1
MK07_HUMAN
A:
[53-354]
---------------------------------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
-
Q
Q
V
A
I
K
K
I
P
N
-
A
F
D
V
V
-
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
R
------
P
TVPYGE
F
----
K
S
-----
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
---
S
-------
Q
-
P
L
T
L
E
H
--
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
-
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-
R
R
Q
L
F
P
G
K
N
Y
-
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
ER
V
--
R
A
Y
-
I
Q
S
L
----
P
-
P
-
R
Q
P
V
P
W
E
T
V
Y
P
--------
G
A
D
R
---
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
-------------------------------------------
448
Blastp_CBE
63.28
49%
-31
- C1 -
-
5LMK
1
?
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
------------------------------------------
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
458
Blastp_CBE
63.11
49%
-27
- C1 -
-
3DOG
1
CDK2_HUMAN
C:
[1-287]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
371
Blastp_CBE
63.11
49%
-29
- C1 -
-
4BCP
1
CDK2_HUMAN
C:
[2-288]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------------
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
363
Blastp_CBE
63.10
49%
-29
- C1 -
-
4CFV
1
CDK2_HUMAN
C:
[5-291]
---------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
K
I
R
L
-
D
T
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
522
Blastp_CBE
62.24
40%
-15
- C1 -
-
2EUF
2
CDK6_HUMAN
B:
[10-303]
----------------------------------------------------------------------------------------------------
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
------
S
----
R
T
DRETK
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
-
Q
M
----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
---------------------------
A
Q
P
I
E
K
F
V
T
---
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
---------------------------------------------
560
HHSearch
61.21
36%
-11
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[5-307]
---------------------------------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
-
Q
Q
V
A
I
K
K
I
P
N
-
A
F
D
V
V
-
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
R
PTVPYG
E
------
F
----
K
S
-----
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
---
S
-------
Q
-
P
L
T
L
E
H
--
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
-
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-
R
R
Q
L
F
P
G
K
N
Y
-
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
--
E
RV
R
A
Y
-
I
Q
S
-
L
---
P
-
P
-
R
Q
P
V
P
W
E
T
V
Y
------
P
--
G
A
D
R
---
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
------------------------------------------
527
Blastp_CBE
60.05
40%
-30
- C1 -
-
5L2S
1
CDK6_HUMAN
A:
[11-300]
-----------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
---------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
---------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
--
L
--
P
R
----
Q
A
F
---
H
-
S
-
K
S
A
Q
P
I
E
K
F
V
T
---
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
------------------------------------------------
526
Blastp_CBE
58.78
40%
-29
- C1 -
-
5L2T
1
CDK6_HUMAN
A:
[11-300]
-----------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
-----------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
---------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
--
L
--
P
R
----
Q
A
F
---
H
-
S
-
K
S
A
Q
P
I
E
K
F
V
T
---
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
------------------------------------------------
521
Blastp_CBE
58.26
40%
-10
- C1 -
-
2F2C
2
CDK6_HUMAN
B:
[9-303]
---------------------------------------------------------------------------------------------------
A
D
Q
Q
Y
E
C
-
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
------
S
-----
T
DRETK
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
-
Q
M
----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
---------------
Q
A
F
---------
A
Q
P
I
E
K
F
V
T
---
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
---------------------------------------------
532
Blastp_CBE
57.49
40%
-31
* C1 *
-
3NUP
1
CDK6_HUMAN
A:
[12-300]
------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
------------
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
-------------K----
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
--
L
--
P
R
----
Q
A
F
---
H
----
S
A
Q
P
I
E
K
F
V
T
---
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
------------------------------------------------
531
Blastp_CBE
57.38
40%
-24
- C1 -
-
3NUX
1
CDK6_HUMAN
A:
[10-300]
----------------------------------------------------------------------------------------------------
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
---------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
--
L
--
P
R
----
Q
A
F
---
H
---
K
S
A
Q
P
I
E
K
F
V
T
---
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
------------------------------------------------
528
Blastp_CBE
56.82
40%
-27
- C1 -
-
5L2I
1
CDK6_HUMAN
A:
[10-300]
----------------------------------------------------------------------------------------------------
D
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
---------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
--
L
--
P
R
----
Q
A
F
-------
K
S
A
Q
P
I
E
K
F
V
T
---
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
------------------------------------------------
529
Blastp_CBE
56.59
40%
-28
- C1 -
-
4EZ5
1
CDK6_HUMAN
A:
[11-300]
-----------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
-----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
---------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
--
L
--
P
R
----
Q
A
F
---
H
----
S
A
Q
P
I
E
K
F
V
T
---
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
------------------------------------------------
530
Blastp_CBE
55.32
40%
-24
- C1 -
-
4AUA
1
CDK6_HUMAN
A:
[11-300]
-----------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
--------------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
---------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
-------------------
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
--
L
--
P
R
----
Q
A
F
---
H
-
S
-
K
S
A
Q
P
I
E
K
F
V
T
---
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
------------------------------------------------
524
Blastp_CBE
52.46
40%
-19
- C1 -
-
4TTH
1
CDK6_HUMAN
B:
[15-303]
---------------------------------------------------------------------------------------------------------
C
V
A
E
I
G
E
----
K
V
F
K
A
R
D
L
K
N
-G
R
F
V
A
L
K
R
V
R
V
-----
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
--------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
-----
P
-
E
P
G
V
P
T
E
T
--
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
-
Q
M
----
A
L
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
-
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
-----------------------------
P
I
E
K
F
-----
D
-
I
--
D
E
L
-----
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
---------------------------------------------
369
Blastp_CBE
45.77
49%
-17
- C1 -
-
1H01
3
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
I
R
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
367
Blastp_CBE
45.29
49%
-15
- C1 -
-
4RJ3
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
I
R
L
D
-
T
E
---------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
368
Blastp_CBE
45.22
49%
-13
- C1 -
-
1OIR
1
CDK2_HUMAN
A:
[3-286]
------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
-
E
V
V
A
L
K
I
R
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
----
N
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
-----
A
L
T
-
G
I
P
L
P
L
--
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
-
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
--
M
--
P
D
Y
-
K
P
S
-
F
---
P
-
K
-
W
A
R
Q
D
F
S
K
V
V
P
---
P
-
L
--
D
E
-----
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------