@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK18_HUMAN: (2021-11-22 )
MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF
Atome Classification :
(509 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130......--.140.......150.......160........170....-.-.-.-180.......190....---...200......------.------210----.--.-----.......220.......230-.--.-.-.---.....240.......250.......260.......270-.-......280.......290.----.....---.300.......310.......320.......330.-......340.......350.......360.......370.---..--....380.....-..--.390........400.......410.......420.......430.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
K
M
K
N
F
K
R
R
FSLSVP
R
T
E
T
I
E
E
S
L
A
E
F
T
E
Q
F
N
Q
L
H
NRRNENLQLGPLGRD
P
P
Q
ECSTFSPTDSGEEPGQLSPG
V
Q
F
Q
R
R
QNQRRF
S
M
E
D
V
S
K
R
LSLPMDIR
L
P
Q
E
F
L
Q
K
L
QMESPDLP
K
P
L
S
R
M
S
R
RASLSDIG
F
G
K
--
L
E
T
Y
V
K
L
DKLGEGT
Y
A
T
V
FK
G
R
S
-
K
L
T
E
N
L
V
A
L
K
E
I
R
L
E-H-E-E-GAP
C
T
A
I
R
E
V
S
L
L
K
NLK---HA
N
I
V
T
L
H
D
L
IH------T------D------R--
S
-----
L
T
L
V
F
E
Y
L
D
S
D
L
K
Q
Y
L
D
H---C--
G
-
N
-
L
---
M
S
M
H
N
V
K
I
F
M
F
Q
L
L
R
G
L
A
Y
C
H
H
R
K
I
L
H
RDLKPQ
N
L
L
IN-E-RG
E
L
K
L
A
DFGLARAKSVPTK----TYSN
E
---
V
V
T
L
W
YR
P
P
D
V
L
LGSTEYSTPID
M
W
G
V
G
C
I
H
Y
EMA-TGRPLFPG
S
T
V
K
E
E
L
H
L
I
F
R
L
LGTPTEETWPG
V
T
A
F
S
EFR---TY--SFPCY-L
P
Q
P
L
I
-NH--APR-LDT
D
G
I
H
L
L
S
S
L
L
L
Y
ESKSRM
S
A
E
A
A
L
S
H
S
Y
F
R
S
L
G
E
R
V
H
Q
L
E
D
T
A
S
I
F
S
L
K
E
I
Q
L
QKDPGYRGLAFQQPGRGKNRRQSIF
21
Blastp_CBE
94.76
78%
-124
- C1 -
-
5G6V
3
CDK16_HUMAN
B:
[1-314]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
-
H
-
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
------
K
--
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
-
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-------------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
---
T
Y
--
N
Y
P
K
Y
-
R
A
E
A
L
L
-
S
H
--
A
P
R
-
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
S
--------------------
2
PsiBlast_PDB
94.03
77%
-111
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[1-313]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
-
H
-
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
------
K
--
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
-
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
D
N
E
---
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
---
T
Y
--
N
Y
P
K
Y
-
R
A
E
A
L
L
-
S
H
--
A
P
R
-
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
---------------------
552
HHSearch
93.60
77%
-111
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[2-313]
---------------------------------------------------------------------------------------------------------------------------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
-
H
-
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
------
K
--
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
-
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
D
N
E
---
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
---
T
Y
--
N
Y
P
K
Y
-
R
A
E
A
L
L
-
S
H
--
A
P
R
-
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
---------------------
1
PsiBlast_PDB
90.24
77%
-120
- C1 -
-
3MTL
-
CDK16_HUMAN
A:
[1-312]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
----------
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
------
K
--
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
-
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
-------------------
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
---
T
Y
--
N
Y
P
K
Y
-
R
A
E
A
L
L
-
S
H
--
A
P
R
-
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
----------------------
551
HHSearch
89.88
77%
-119
- C1 -
-
3MTL
-
CDK16_HUMAN
A:
[2-312]
---------------------------------------------------------------------------------------------------------------------------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
----------
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
------
K
--
S
-----
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
-
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
-------------------
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
---
T
Y
--
N
Y
P
K
Y
-
R
A
E
A
L
L
-
S
H
--
A
P
R
-
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
----------------------
439
Blastp_CBE
80.30
51%
-124
- C1 -
-
3NIZ
1
?
A:
[18-311]
----------------------------------------------------------------------------------------------------------------------------------------
G
L
--
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
-
S
-
Q
G
R
I
V
A
L
K
R
I
R
---------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
---
H
P
N
I
V
S
L
I
D
V
I
H
------
S
------
E
------
R
--
C
-----
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
--
K
-
T
-
G
---
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-------
H
E
---
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
---
Q
R
--
T
F
Q
V
F
-
E
K
K
P
W
S
-
S
I
--
I
P
G
-
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
------------------------------------------
54
Blastp_CBE
79.14
53%
-59
- C1 -
-
4FKU
3
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
560
HHSearch
78.92
54%
-115
- C1 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-286]
----------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
-------------
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
------
K
--
R
-----
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
--
E
-
G
-
G
---
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
---
P
---
N
F
T
V
Y
-
E
P
L
P
W
E
-
S
F
--
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-----------------------------------------------
321
Blastp_CBE
78.80
54%
-121
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-285]
----------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
-
A
L
K
K
I
R
L
-----------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
------
K
--
R
-----
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
--
E
-
G
-
G
---
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
---
P
---
N
F
T
V
Y
-
E
P
L
P
W
E
-
S
F
--
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
------------------------------------------------
320
Blastp_CBE
78.47
54%
-116
- C1 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-285]
----------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
-
A
L
K
K
I
R
L
-------------
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
------
K
--
R
-----
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
--
E
-
G
-
G
---
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
---
P
---
N
F
T
V
Y
-
E
P
L
P
W
E
-
S
F
--
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
------------------------------------------------
444
Blastp_CBE
77.51
53%
-56
- C1 -
-
4ERW
17
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
S
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
410
Blastp_CBE
77.50
53%
-51
- C1 -
-
2IW9
1
CDK2_HUMAN
A:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
148
Blastp_CBE
76.96
53%
-63
- C1 -
-
2C5Y
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
125
Blastp_CBE
76.88
53%
-62
- C1 -
-
2UZO
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
99
Blastp_CBE
76.82
53%
-51
- C1 -
-
2XNB
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
140
Blastp_CBE
76.80
53%
-55
- C1 -
-
2CLX
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
60
Blastp_CBE
76.68
53%
-58
- C1 -
-
4FKO
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
100
Blastp_CBE
76.55
53%
-55
- C1 -
-
2XMY
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
225
Blastp_CBE
76.47
53%
-56
- C1 -
-
6Q4C
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
511
Blastp_CBE
76.46
53%
-45
- C1 -
-
4EOI
2
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
361
Blastp_CBE
76.38
53%
-47
- C1 -
-
4EOS
1
CDK2_HUMAN
A:
[2-299]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
145
Blastp_CBE
76.16
53%
-60
- C1 -
-
2C6I
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
147
Blastp_CBE
76.09
53%
-54
- C1 -
-
2C68
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
448
Blastp_CBE
76.08
53%
-48
- C1 -
-
4EOO
1
CDK2_HUMAN
A:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
215
Blastp_CBE
76.00
53%
-59
- C1 -
-
1B38
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
181
Blastp_CBE
75.99
53%
-59
- C1 -
-
1PXL
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
437
Blastp_CBE
75.76
53%
-55
- C1 -
-
1W8C
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
W
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
52
Blastp_CBE
75.82
53%
-66
- C1 -
-
4FKW
2
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
124
Blastp_CBE
75.80
53%
-54
- C1 -
-
2V0D
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
144
Blastp_CBE
75.76
53%
-55
- C1 -
-
2C6K
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
141
Blastp_CBE
75.68
53%
-55
- C1 -
-
2C6O
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
169
Blastp_CBE
75.66
53%
-58
- C1 -
-
1Y8Y
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
168
Blastp_CBE
75.66
53%
-60
- C1 -
-
1Y91
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
36
Blastp_CBE
75.60
53%
-59
- C1 -
-
5IEX
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
209
Blastp_CBE
75.56
53%
-54
- C1 -
-
1E1X
2
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
422
Blastp_CBE
75.53
53%
-43
- C1 -
-
4EOJ
1
CDK2_HUMAN
A:
[3-300]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
220
Blastp_CBE
75.52
53%
-54
- C1 -
-
6Q4K
3
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
340
Blastp_CBE
75.41
54%
-137
- C1 -
-
1V0P
1
CDC2H_PLAFK
B:
[2-285]
---------------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
-
A
L
K
--------------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
----------------------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
--
E
-
G
-
G
---
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
--------------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
---
P
---
N
F
T
V
Y
-
E
P
L
P
W
E
-
S
F
--
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
------------------------------------------------
227
Blastp_CBE
75.41
53%
-55
- C1 -
-
6Q4A
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
453
Blastp_CBE
75.27
53%
-53
- C1 -
-
4RJ3
1
CDK2_HUMAN
A:
[1-295]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
L
I
R
L
D
-
T
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
74
Blastp_CBE
75.36
53%
-61
- C1 -
-
3WBL
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
197
Blastp_CBE
75.34
53%
-53
- C1 -
-
1H0V
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
---
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
182
Blastp_CBE
75.30
53%
-60
- C1 -
-
1PXK
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
35
Blastp_CBE
75.29
53%
-58
- C1 -
-
5IEY
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
339
Blastp_CBE
75.27
53%
-52
- C1 -
-
6Q4I
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
L
---
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
226
Blastp_CBE
75.21
53%
-54
- C1 -
-
6Q4B
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
222
Blastp_CBE
75.21
53%
-57
- C1 -
-
6Q4H
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
119
Blastp_CBE
75.22
53%
-56
- C1 -
-
2VTL
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
146
Blastp_CBE
75.20
53%
-58
- C1 -
-
2C69
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
188
Blastp_CBE
75.21
53%
-63
- C1 -
-
1KE9
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
84
Blastp_CBE
75.20
53%
-54
- C1 -
-
3NS9
1
CDK2_HUMAN
A:
[3-296]
----------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
143
Blastp_CBE
75.19
53%
-55
- C1 -
-
2C6L
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
171
Blastp_CBE
75.15
53%
-63
- C1 -
-
1W0X
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
194
Blastp_CBE
75.13
53%
-55
- C1 -
-
1JSV
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
142
Blastp_CBE
75.08
53%
-56
- C1 -
-
2C6M
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
436
Blastp_CBE
74.98
53%
-60
- C1 -
-
2R3I
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
429
Blastp_CBE
74.98
53%
-56
- C1 -
-
2R3P
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
130
Blastp_CBE
74.95
53%
-58
- C1 -
-
2R3R
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
317
Blastp_CBE
74.94
53%
-58
- C1 -
-
5OO3
1
CDK2_HUMAN
A:
[7-299]
---------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
61
Blastp_CBE
74.92
53%
-59
- C1 -
-
4FKL
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
462
Blastp_CBE
74.89
53%
-49
- C1 -
-
4EOR
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
428
Blastp_CBE
74.88
53%
-54
- C1 -
-
2R3Q
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
316
Blastp_CBE
74.87
53%
-52
- C1 -
-
5OSM
1
CDK2_HUMAN
A:
[3-301]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
224
Blastp_CBE
74.85
53%
-55
- C1 -
-
6Q4D
6
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
426
Blastp_CBE
74.74
53%
-46
- C1 -
-
4EOK
1
CDK2_HUMAN
A:
[3-299]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
63
Blastp_CBE
74.83
53%
-53
- C1 -
-
4FKI
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
89
Blastp_CBE
74.82
53%
-57
- C1 -
-
3IGG
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
214
Blastp_CBE
74.81
53%
-58
- C1 -
-
1B39
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
192
Blastp_CBE
74.79
53%
-64
- C1 -
-
1KE5
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
116
Blastp_CBE
74.77
53%
-58
- C1 -
-
2VTO
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
85
Blastp_CBE
74.74
53%
-50
- C1 -
-
3LFS
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
191
Blastp_CBE
74.73
53%
-65
- C1 -
-
1KE6
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
64
Blastp_CBE
74.68
53%
-54
- C1 -
-
4FKG
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
67
Blastp_CBE
74.63
53%
-55
- C1 -
-
4EK5
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
112
Blastp_CBE
74.60
53%
-60
- C1 -
-
2VTS
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
37
Blastp_CBE
74.60
53%
-59
- C1 -
-
5IEV
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
196
Blastp_CBE
74.52
53%
-56
- C1 -
-
1H0W
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
77
Blastp_CBE
74.52
53%
-57
- C1 -
-
3ULI
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
199
Blastp_CBE
74.50
53%
-54
- C1 -
-
1H07
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
53
Blastp_CBE
74.44
53%
-58
- C1 -
-
4FKV
2
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
430
Blastp_CBE
74.39
53%
-56
- C1 -
-
2R3O
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
132
Blastp_CBE
74.37
53%
-52
- C1 -
-
2R3G
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
91
Blastp_CBE
74.35
53%
-56
- C1 -
-
3FZ1
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
68
Blastp_CBE
74.33
53%
-56
- C1 -
-
4EK4
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
298
Blastp_CBE
74.29
53%
-57
- C1 -
-
3QTR
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
190
Blastp_CBE
74.28
53%
-60
- C1 -
-
1KE7
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
443
Blastp_CBE
74.27
53%
-55
- C1 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-304]
---------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
165
Blastp_CBE
74.26
53%
-59
- C1 -
-
2A4L
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
441
Blastp_CBE
74.18
53%
-54
- C1 -
-
6Q4F
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
212
Blastp_CBE
74.14
53%
-54
- C1 -
-
1DI8
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
198
Blastp_CBE
74.12
53%
-56
- C1 -
-
1H08
2
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
47
Blastp_CBE
74.11
53%
-53
- C1 -
-
5A14
2
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
481
Blastp_CBE
74.06
53%
-46
- C1 -
-
6GVA
3
CDK2_HUMAN
A:
[2-291]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
---------------------------------------------
180
Blastp_CBE
74.04
53%
-53
- C1 -
-
1PXM
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
504
Blastp_CBE
74.01
53%
-58
- C1 -
-
5MHQ
1
?
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
-
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
446
Blastp_CBE
73.99
53%
-15
- C1 -
-
4EOP
1
CDK2_HUMAN
A:
[2-299]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
273
Blastp_CBE
73.98
53%
-58
- C1 -
-
3R7I
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
243
Blastp_CBE
73.85
53%
-58
- C1 -
-
3RPR
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
189
Blastp_CBE
73.87
53%
-58
- C1 -
-
1KE8
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
210
Blastp_CBE
73.85
53%
-52
- C1 -
-
1E1V
2
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
118
Blastp_CBE
73.83
53%
-55
- C1 -
-
2VTM
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
133
Blastp_CBE
73.82
53%
-57
- C1 -
-
2R3F
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
335
Blastp_CBE
73.76
53%
-21
- C1 -
-
2BKZ
1
CDK2_HUMAN
A:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
107
Blastp_CBE
73.80
53%
-53
- C1 -
-
2W06
2
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
272
Blastp_CBE
73.79
53%
-58
- C1 -
-
3R7U
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
334
Blastp_CBE
73.76
53%
-22
- C1 -
-
2BKZ
1
CDK2_HUMAN
C:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
131
Blastp_CBE
73.69
53%
-54
- C1 -
-
2R3H
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
126
Blastp_CBE
73.64
53%
-59
- C1 -
-
2UZN
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
221
Blastp_CBE
73.62
53%
-59
- C1 -
-
6Q4J
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
58
Blastp_CBE
73.58
53%
-57
- C1 -
-
4FKQ
2
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
113
Blastp_CBE
73.56
53%
-53
- C1 -
-
2VTR
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
109
Blastp_CBE
73.55
53%
-61
- C1 -
-
2VV9
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
300
Blastp_CBE
73.52
53%
-15
- C1 -
-
3QRU
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
325
Blastp_CBE
73.47
53%
-18
- C1 -
-
2WPA
1
CDK2_HUMAN
A:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
319
Blastp_CBE
73.38
53%
-57
- C1 -
-
6Q4G
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
359
Blastp_CBE
73.37
53%
-13
- C1 -
-
1OGU
1
CDK2_HUMAN
A:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------
P
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
206
Blastp_CBE
73.32
53%
-21
- C1 -
-
1FIN
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
57
Blastp_CBE
73.27
53%
-58
- C1 -
-
4FKR
2
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
219
Blastp_CBE
73.23
53%
-56
- C1 -
-
5K4J
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
260
Blastp_CBE
73.20
53%
-57
- C1 -
-
3R9N
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
297
Blastp_CBE
73.18
53%
-57
- C1 -
-
3QTS
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
230
Blastp_CBE
73.13
53%
-59
- C1 -
-
6Q3B
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
372
Blastp_CBE
73.14
53%
-13
- C1 -
-
4BCN
1
CDK2_HUMAN
C:
[1-296]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
83
Blastp_CBE
73.13
53%
-62
- C1 -
-
3S2P
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
258
Blastp_CBE
73.11
53%
-59
- C1 -
-
3RAH
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
350
Blastp_CBE
73.01
53%
-16
- C1 -
-
4CFN
1
CDK2_HUMAN
C:
[2-298]
---------------------------------------------------------------------------------------------------------------------------------------
P
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
451
Blastp_CBE
72.96
53%
-15
- C1 -
-
4EON
1
CDK2_HUMAN
C:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
205
Blastp_CBE
73.06
53%
-57
- C1 -
-
1FVT
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
223
Blastp_CBE
73.05
53%
-59
- C1 -
-
6Q4E
3
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
472
Blastp_CBE
72.93
53%
-17
- C1 -
-
2UZB
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
390
Blastp_CBE
73.04
53%
-15
- C1 -
-
5NEV
1
?
C:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
259
Blastp_CBE
73.01
53%
-54
- C1 -
-
3R9O
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
413
Blastp_CBE
72.98
53%
-14
- C1 -
-
3QHW
3
CDK2_HUMAN
C:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
59
Blastp_CBE
72.97
53%
-58
- C1 -
-
4FKP
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
92
Blastp_CBE
72.96
53%
-19
- C1 -
-
3F5X
2
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
290
Blastp_CBE
72.91
53%
-15
- C1 -
-
3QWK
5
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
510
Blastp_CBE
72.82
53%
-17
- C1 -
-
4EOI
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
27
Blastp_CBE
72.93
53%
-58
- C1 -
-
3EZV
1
CDK2_HUMAN
A:
[3-298]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
377
Blastp_CBE
72.92
53%
-18
- C1 -
-
3TNW
1
CDK2_HUMAN
A:
[2-298]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
167
Blastp_CBE
72.91
53%
-14
- C1 -
-
1YKR
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
373
Blastp_CBE
72.89
53%
-16
- C1 -
-
4BCN
1
CDK2_HUMAN
A:
[2-298]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
463
Blastp_CBE
72.88
53%
-17
- C1 -
-
4II5
3
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
307
Blastp_CBE
72.86
53%
-14
- C1 -
-
3QQF
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
475
Blastp_CBE
72.84
53%
-20
- C1 -
-
2C6T
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
353
Blastp_CBE
72.77
53%
-14
- C1 -
-
1OIY
1
CDK2_HUMAN
A:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
281
Blastp_CBE
72.83
53%
-9
- C1 -
-
3R1Q
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
349
Blastp_CBE
72.76
53%
-11
- C1 -
-
6GUB
1
CDK2_HUMAN
A:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
121
Blastp_CBE
72.81
53%
-63
- C1 -
-
2VTI
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
414
Blastp_CBE
72.73
53%
-13
- C1 -
-
3QHW
2
CDK2_HUMAN
A:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
88
Blastp_CBE
72.81
53%
-51
- C1 -
-
3LE6
1
CDK2_HUMAN
A:
[1-294]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
----------------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
502
Blastp_CBE
72.79
53%
-11
- C1 -
-
4I3Z
3
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
357
Blastp_CBE
72.78
53%
-15
- C1 -
-
1OI9
1
CDK2_HUMAN
A:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
213
Blastp_CBE
72.77
53%
-63
- C1 -
-
1CKP
2
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
240
Blastp_CBE
72.76
53%
-54
- C1 -
-
3RZB
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
464
Blastp_CBE
72.65
53%
-16
- C1 -
-
4II5
2
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
253
Blastp_CBE
72.71
53%
-12
- C1 -
-
3RK5
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
408
Blastp_CBE
72.74
53%
-19
- C1 -
-
1H1P
1
CDK2_HUMAN
A:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
241
Blastp_CBE
72.73
53%
-59
- C1 -
-
3RPY
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
450
Blastp_CBE
72.72
53%
-14
* C1 *
-
4EOM
1
CDK2_HUMAN
A:
[3-300]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
425
Blastp_CBE
72.62
53%
-12
- C1 -
-
4EOK
1
CDK2_HUMAN
C:
[1-299]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
248
Blastp_CBE
72.71
53%
-15
- C1 -
-
3RM7
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
156
Blastp_CBE
72.69
53%
-18
- C1 -
-
2C5N
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
110
Blastp_CBE
72.68
53%
-53
- C1 -
-
2VU3
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
----
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
323
Blastp_CBE
72.60
53%
-18
- C1 -
-
2WXV
1
CDK2_HUMAN
A:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
337
Blastp_CBE
72.59
53%
-19
- C1 -
-
1VYW
1
CDK2_HUMAN
A:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
93
Blastp_CBE
72.64
53%
-22
- C1 -
-
3F5X
2
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
503
Blastp_CBE
72.49
53%
-13
- C1 -
-
4I3Z
4
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
97
Blastp_CBE
72.60
53%
-17
- C1 -
-
3EJ1
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
96
Blastp_CBE
72.60
53%
-16
- C1 -
-
3EJ1
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
3
PsiBlast_PDB
72.59
57%
-58
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[6-290]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
------------
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
-----------------------
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
-
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
------
S
A
E
---
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
---
P
Y
----
P
M
Y
P
A
T
T
S
L
V
-
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-------------------------------------------------
346
Blastp_CBE
72.52
53%
-14
- C1 -
-
6GUC
1
CDK2_HUMAN
C:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
251
Blastp_CBE
72.54
53%
-13
- C1 -
-
3RK9
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
237
Blastp_CBE
72.54
53%
-60
- C1 -
-
3S1H
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
356
Blastp_CBE
72.50
53%
-16
- C1 -
-
1OI9
1
CDK2_HUMAN
C:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
355
Blastp_CBE
72.49
53%
-15
- C1 -
-
1OIU
1
CDK2_HUMAN
A:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------
P
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
265
Blastp_CBE
72.55
53%
-15
- C1 -
-
3R8U
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
393
Blastp_CBE
72.47
53%
-14
- C1 -
-
5CYI
1
CDK2_HUMAN
A:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
73
Blastp_CBE
72.54
53%
-56
- C1 -
-
4ACM
3
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
----------------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
283
Blastp_CBE
72.53
53%
-8
- C1 -
-
3QZH
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
329
Blastp_CBE
72.52
53%
-14
- C1 -
-
2WIH
1
CDK2_HUMAN
A:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
405
Blastp_CBE
72.43
53%
-17
- C1 -
-
1H1Q
1
CDK2_HUMAN
C:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
166
Blastp_CBE
72.50
53%
-13
- C1 -
-
2A0C
1
CDK2_HUMAN
X:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
303
Blastp_CBE
72.49
53%
-15
- C1 -
-
3QQK
6
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
381
Blastp_CBE
72.48
53%
-13
- C1 -
-
3BHV
2
CDK2_HUMAN
A:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
351
Blastp_CBE
72.47
53%
-17
- C1 -
-
4CFN
1
CDK2_HUMAN
A:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------
P
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
229
Blastp_CBE
72.46
53%
-59
- C1 -
-
6Q48
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
415
Blastp_CBE
72.45
53%
-15
- C1 -
-
3QHR
2
CDK2_HUMAN
C:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
115
Blastp_CBE
72.43
53%
-54
- C1 -
-
2VTP
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
65
Blastp_CBE
72.43
53%
-55
- C1 -
-
4EK8
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
397
Blastp_CBE
72.42
53%
-18
- C1 -
-
4CFW
1
CDK2_HUMAN
A:
[4-301]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
493
Blastp_CBE
72.16
53%
-16
- C1 -
-
2CCI
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
402
Blastp_CBE
72.40
53%
-16
- C1 -
-
1H1S
1
CDK2_HUMAN
A:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
152
Blastp_CBE
72.38
53%
-20
- C1 -
-
2C5V
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
327
Blastp_CBE
72.37
53%
-20
- C1 -
-
2WIP
1
CDK2_HUMAN
A:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
482
Blastp_CBE
72.23
53%
-14
- C1 -
-
5LMK
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
466
Blastp_CBE
72.34
53%
-17
- C1 -
-
2UZL
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
344
Blastp_CBE
72.28
53%
-14
- C1 -
-
6GUF
1
CDK2_HUMAN
A:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
250
Blastp_CBE
72.30
53%
-14
- C1 -
-
3RKB
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
465
Blastp_CBE
72.22
53%
-17
- C1 -
-
2UZL
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
434
Blastp_CBE
72.23
53%
-60
- C1 -
-
2R3K
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
245
Blastp_CBE
72.29
53%
-12
- C1 -
-
3ROY
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
406
Blastp_CBE
72.23
53%
-12
- C1 -
-
1H1Q
1
CDK2_HUMAN
A:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
403
Blastp_CBE
72.23
53%
-13
- C1 -
-
1H1R
1
CDK2_HUMAN
C:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
445
Blastp_CBE
72.11
53%
-11
- C1 -
-
4EOP
1
CDK2_HUMAN
C:
[3-299]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
55
Blastp_CBE
72.30
53%
-56
- C1 -
-
4FKT
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
134
Blastp_CBE
72.29
53%
-59
- C1 -
-
2J9M
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
333
Blastp_CBE
72.28
53%
-18
- C1 -
-
2BPM
1
CDK2_HUMAN
A:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
81
Blastp_CBE
72.27
53%
-60
- C1 -
-
3SW7
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
22
Blastp_CBE
72.27
57%
-64
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[6-290]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
------
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
-------------
K
--
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
-
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
-------------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
---
P
Y
----
P
M
Y
P
A
T
T
S
L
V
-
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-------------------------------------------------
122
Blastp_CBE
72.26
53%
-61
- C1 -
-
2VTH
2
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
399
Blastp_CBE
72.17
53%
-13
- C1 -
-
4CFM
1
CDK2_HUMAN
A:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
366
Blastp_CBE
72.17
53%
-18
- C1 -
-
4EOQ
1
CDK2_HUMAN
A:
[3-300]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
452
Blastp_CBE
72.13
53%
-12
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
288
Blastp_CBE
72.23
53%
-13
- C1 -
-
3QX4
3
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
244
Blastp_CBE
72.22
53%
-14
- C1 -
-
3RPO
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
301
Blastp_CBE
72.21
53%
-15
- C1 -
-
3QRT
3
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
271
Blastp_CBE
72.17
53%
-12
- C1 -
-
3R7V
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
435
Blastp_CBE
72.11
53%
-60
- C1 -
-
2R3J
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
154
Blastp_CBE
72.18
53%
-16
- C1 -
-
2C5O
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
394
Blastp_CBE
72.19
53%
-14
- C1 -
-
4CFX
1
CDK2_HUMAN
C:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
123
Blastp_CBE
72.18
53%
-61
- C1 -
-
2VTA
3
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
494
Blastp_CBE
71.93
53%
-18
- C1 -
-
2CCH
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
155
Blastp_CBE
72.17
53%
-14
- C1 -
-
2C5N
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
392
Blastp_CBE
72.01
53%
-12
- C1 -
-
5CYI
1
CDK2_HUMAN
C:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
136
Blastp_CBE
72.16
53%
-22
- C1 -
-
2I40
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
261
Blastp_CBE
72.11
53%
-12
- C1 -
-
3R9H
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
200
Blastp_CBE
72.14
53%
-57
- C1 -
-
1H00
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
207
Blastp_CBE
72.11
53%
-16
- C1 -
-
1FIN
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
375
Blastp_CBE
72.13
53%
-11
- C1 -
-
4BCK
2
CDK2_HUMAN
A:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
172
Blastp_CBE
72.11
53%
-53
- C1 -
-
1VYZ
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
71
Blastp_CBE
72.11
53%
-60
- C1 -
-
4BZD
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
470
Blastp_CBE
72.09
53%
-15
- C1 -
-
2UZD
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
336
Blastp_CBE
72.03
53%
-19
- C1 -
-
1VYW
1
CDK2_HUMAN
C:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
287
Blastp_CBE
72.08
53%
-13
- C1 -
-
3QXO
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
487
Blastp_CBE
71.96
53%
-14
- C1 -
-
3DDQ
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
274
Blastp_CBE
72.07
53%
-11
- C1 -
-
3R7E
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
326
Blastp_CBE
72.00
53%
-19
- C1 -
-
2WIP
1
CDK2_HUMAN
C:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
276
Blastp_CBE
72.05
53%
-12
- C1 -
-
3R71
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
86
Blastp_CBE
72.04
53%
-51
- C1 -
-
3LFQ
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
128
Blastp_CBE
72.03
53%
-19
- C1 -
-
2UUE
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
497
Blastp_CBE
71.89
53%
-15
- C1 -
-
1QMZ
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
376
Blastp_CBE
72.01
53%
-10
- C1 -
-
3TNW
1
CDK2_HUMAN
C:
[3-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
492
Blastp_CBE
71.89
53%
-21
- C1 -
-
2CCI
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
246
Blastp_CBE
72.00
53%
-11
- C1 -
-
3RNI
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
471
Blastp_CBE
71.99
53%
-21
- C1 -
-
2UZB
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
332
Blastp_CBE
71.98
53%
-17
- C1 -
-
2BPM
1
CDK2_HUMAN
C:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
330
Blastp_CBE
71.92
53%
-18
- C1 -
-
2C4G
1
CDK2_HUMAN
C:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
424
Blastp_CBE
71.97
53%
-13
- C1 -
-
4EOL
1
CDK2_HUMAN
A:
[3-299]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
---L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
159
Blastp_CBE
71.96
53%
-62
- C1 -
-
2BHH
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
324
Blastp_CBE
71.89
53%
-14
- C1 -
-
2WPA
1
CDK2_HUMAN
C:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
179
Blastp_CBE
71.94
53%
-7
- C1 -
-
1PXN
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
433
Blastp_CBE
71.84
53%
-62
- C1 -
-
2R3L
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
322
Blastp_CBE
71.93
53%
-16
- C1 -
-
2WXV
1
CDK2_HUMAN
C:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
33
Blastp_CBE
71.92
53%
-59
- C1 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-296]
----------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
491
Blastp_CBE
71.91
53%
-14
- C1 -
-
2G9X
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
407
Blastp_CBE
71.82
53%
-18
- C1 -
-
1H1P
1
CDK2_HUMAN
C:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
423
Blastp_CBE
71.90
53%
-14
- C1 -
-
4EOL
1
CDK2_HUMAN
C:
[1-299]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
416
Blastp_CBE
71.81
53%
-14
- C1 -
-
3QHR
6
CDK2_HUMAN
A:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
153
Blastp_CBE
71.89
53%
-17
- C1 -
-
2C5O
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
391
Blastp_CBE
71.81
53%
-12
- C1 -
-
5NEV
1
CDK2_HUMAN
A:
[5-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
----------------------------------------
420
Blastp_CBE
71.88
53%
-10
- C1 -
-
4CFU
1
CDK2_HUMAN
A:
[4-301]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
468
Blastp_CBE
71.76
53%
-19
- C1 -
-
2UZE
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
242
Blastp_CBE
71.84
53%
-13
- C1 -
-
3RPV
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
447
Blastp_CBE
71.85
53%
-15
- C1 -
-
4EOO
1
CDK2_HUMAN
C:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
94
Blastp_CBE
71.84
53%
-20
- C1 -
-
3EOC
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
385
Blastp_CBE
71.82
53%
-13
- C1 -
-
3BHT
1
CDK2_HUMAN
A:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
396
Blastp_CBE
71.73
53%
-14
- C1 -
-
4CFW
1
CDK2_HUMAN
C:
[4-301]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
360
Blastp_CBE
71.73
53%
-16
- C1 -
-
4EOS
1
CDK2_HUMAN
C:
[3-299]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
401
Blastp_CBE
71.79
53%
-10
- C1 -
-
1H1S
1
CDK2_HUMAN
C:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
50
Blastp_CBE
71.77
53%
-15
- C1 -
-
4FX3
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
277
Blastp_CBE
71.73
53%
-13
- C1 -
-
3R6X
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
127
Blastp_CBE
71.76
53%
-16
- C1 -
-
2UUE
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
479
Blastp_CBE
71.75
53%
-14
- C1 -
-
1JST
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
262
Blastp_CBE
71.73
53%
-12
- C1 -
-
3R9D
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
106
Blastp_CBE
71.70
53%
-63
- C1 -
-
2W17
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
---------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
108
Blastp_CBE
71.69
53%
-62
- C1 -
-
2W05
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
135
Blastp_CBE
71.67
53%
-19
- C1 -
-
2I40
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
95
Blastp_CBE
71.68
53%
-21
- C1 -
-
3EOC
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
70
Blastp_CBE
71.67
53%
-56
- C1 -
-
4D1X
1
CDK2_HUMAN
A:
[3-296]
----------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
292
Blastp_CBE
71.66
53%
-13
- C1 -
-
3QU0
5
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
498
Blastp_CBE
71.53
53%
-15
- C1 -
-
1P5E
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
177
Blastp_CBE
71.62
53%
-8
- C1 -
-
1PXP
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
457
Blastp_CBE
71.41
53%
-12
- C1 -
-
1PKD
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
284
Blastp_CBE
71.55
53%
-13
- C1 -
-
3QZG
3
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
469
Blastp_CBE
71.59
53%
-25
- C1 -
-
2UZD
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
369
Blastp_CBE
71.58
53%
-12
- C1 -
-
4BCP
1
CDK2_HUMAN
A:
[2-298]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
496
Blastp_CBE
71.45
53%
-15
- C1 -
-
1QMZ
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
295
Blastp_CBE
71.53
53%
-13
- C1 -
-
3QTW
7
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
352
Blastp_CBE
71.51
53%
-14
- C1 -
-
1OIY
1
CDK2_HUMAN
C:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
204
Blastp_CBE
71.55
53%
-16
- C1 -
-
1FVV
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
56
Blastp_CBE
71.57
53%
-62
- C1 -
-
4FKS
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
282
Blastp_CBE
71.51
53%
-9
- C1 -
-
3QZI
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
404
Blastp_CBE
71.46
53%
-8
- C1 -
-
1H1R
1
CDK2_HUMAN
A:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
104
Blastp_CBE
71.54
53%
-16
- C1 -
-
2WEV
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
257
Blastp_CBE
71.53
53%
-12
- C1 -
-
3RAI
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
331
Blastp_CBE
71.46
53%
-16
- C1 -
-
2C4G
1
CDK2_HUMAN
A:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
256
Blastp_CBE
71.51
53%
-60
- C1 -
-
3RAK
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
266
Blastp_CBE
71.50
53%
-11
- C1 -
-
3R8P
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
293
Blastp_CBE
71.45
53%
-12
- C1 -
-
3QTZ
3
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
432
Blastp_CBE
71.49
53%
-59
- C1 -
-
2R3M
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
458
Blastp_CBE
71.38
53%
-20
- C1 -
-
1PKD
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
278
Blastp_CBE
71.46
53%
-11
- C1 -
-
3R28
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
314
Blastp_CBE
71.41
53%
-10
- C1 -
-
3PXQ
4
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
418
Blastp_CBE
71.36
53%
-11
- C1 -
-
4CFV
1
CDK2_HUMAN
A:
[4-301]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
302
Blastp_CBE
71.38
53%
-11
- C1 -
-
3QQL
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
291
Blastp_CBE
71.41
53%
-13
- C1 -
-
3QWJ
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
270
Blastp_CBE
71.38
53%
-14
- C1 -
-
3R7Y
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
500
Blastp_CBE
71.25
53%
-18
- C1 -
-
1GY3
2
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
275
Blastp_CBE
71.36
53%
-14
- C1 -
-
3R73
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
299
Blastp_CBE
71.35
53%
-13
- C1 -
-
3QTQ
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
280
Blastp_CBE
71.34
53%
-10
- C1 -
-
3R1S
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
203
Blastp_CBE
71.33
53%
-19
- C1 -
-
1FVV
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
411
Blastp_CBE
71.31
53%
-14
- C1 -
-
2IW6
1
CDK2_HUMAN
C:
[4-299]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
----------------------------------------
495
Blastp_CBE
71.18
53%
-20
- C1 -
-
2CCH
3
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
467
Blastp_CBE
71.19
53%
-14
- C1 -
-
2UZE
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
161
Blastp_CBE
71.29
53%
-56
- C1 -
-
2B55
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
459
Blastp_CBE
71.18
53%
-10
- C1 -
-
1E9H
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
49
Blastp_CBE
71.26
53%
-14
- C1 -
-
4KD1
2
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
231
Blastp_CBE
71.23
53%
-59
- C1 -
-
6GUK
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
371
Blastp_CBE
71.25
53%
-12
- C1 -
-
4BCO
1
CDK2_HUMAN
A:
[2-298]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
137
Blastp_CBE
71.23
53%
-54
- C1 -
-
2FVD
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------------
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
489
Blastp_CBE
71.11
53%
-11
- C1 -
-
3DDP
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
138
Blastp_CBE
71.22
53%
-9
- C1 -
-
2EXM
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
72
Blastp_CBE
71.20
53%
-66
- C1 -
-
4BGH
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
389
Blastp_CBE
71.19
53%
-15
- C1 -
-
4BCM
1
CDK2_HUMAN
A:
[2-299]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
289
Blastp_CBE
71.18
53%
-12
- C1 -
-
3QX2
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
476
Blastp_CBE
71.06
53%
-14
- C1 -
-
2C6T
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
268
Blastp_CBE
71.12
53%
-12
- C1 -
-
3R8L
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
386
Blastp_CBE
71.06
53%
-13
- C1 -
-
4BCQ
1
CDK2_HUMAN
C:
[3-297]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
306
Blastp_CBE
71.13
53%
-12
- C1 -
-
3QQG
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
151
Blastp_CBE
71.12
53%
-16
- C1 -
-
2C5V
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
285
Blastp_CBE
71.11
53%
-14
- C1 -
-
3QZF
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
383
Blastp_CBE
71.03
53%
-11
- C1 -
-
3BHU
1
CDK2_HUMAN
A:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
264
Blastp_CBE
71.08
53%
-12
- C1 -
-
3R8V
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
255
Blastp_CBE
71.07
53%
-59
- C1 -
-
3RAL
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
62
Blastp_CBE
71.06
53%
-59
- C1 -
-
4FKJ
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
46
Blastp_CBE
71.06
53%
-63
- C1 -
-
5AND
1
CDK2_HUMAN
A:
[2-294]
---------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
252
Blastp_CBE
71.01
53%
-11
- C1 -
-
3RK7
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
163
Blastp_CBE
71.04
53%
-7
- C1 -
-
2B53
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
395
Blastp_CBE
70.96
53%
-19
- C1 -
-
4CFX
1
CDK2_HUMAN
A:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
25
Blastp_CBE
71.03
57%
-71
- C1 -
-
1UNG
1
CDK5_HUMAN
B:
[2-286]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
-------
T
V
F
K
A
--------
I
V
A
L
K
R
V
R
L
D
-------
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
------
K
--
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
-
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
---
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
---
P
Y
----
P
M
Y
P
A
T
T
S
L
V
-
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-------------------------------------------------
328
Blastp_CBE
71.02
53%
-17
- C1 -
-
2WIH
1
CDK2_HUMAN
C:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
51
Blastp_CBE
71.01
53%
-12
- C1 -
-
4FX3
2
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
364
Blastp_CBE
70.97
53%
-59
- C1 -
-
1GII
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
195
Blastp_CBE
70.96
53%
-10
- C1 -
-
1HCK
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
488
Blastp_CBE
70.84
53%
-16
- C1 -
-
3DDP
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
379
Blastp_CBE
70.88
53%
-13
- C1 -
-
3MY5
3
CDK2_HUMAN
A:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
76
Blastp_CBE
70.94
53%
-9
- C1 -
-
3UNJ
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
201
Blastp_CBE
70.91
53%
-61
- C1 -
-
1GIH
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
234
Blastp_CBE
70.90
53%
-8
- C1 -
-
4EZ7
7
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
315
Blastp_CBE
70.84
53%
-5
- C1 -
-
3PXF
7
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
101
Blastp_CBE
70.88
53%
-13
- C1 -
-
2X1N
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
460
Blastp_CBE
70.77
53%
-15
- C1 -
-
1E9H
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
102
Blastp_CBE
70.87
53%
-14
- C1 -
-
2X1N
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
75
Blastp_CBE
70.87
53%
-10
- C1 -
-
3UNK
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
211
Blastp_CBE
70.84
53%
-62
- C1 -
-
1DM2
5
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
374
Blastp_CBE
70.77
53%
-16
- C1 -
-
4BCK
1
CDK2_HUMAN
C:
[1-296]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
304
Blastp_CBE
70.81
53%
-13
- C1 -
-
3QQJ
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
269
Blastp_CBE
70.80
53%
-11
- C1 -
-
3R83
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
82
Blastp_CBE
70.79
53%
-58
- C1 -
-
3SW4
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
150
Blastp_CBE
70.76
53%
-11
- C1 -
-
2C5X
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
279
Blastp_CBE
70.77
53%
-14
- C1 -
-
3R1Y
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
45
Blastp_CBE
70.76
53%
-13
- C1 -
-
5ANE
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
6
PsiBlast_PDB
70.76
56%
-17
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-286]
--------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
-
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
------
K
--
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
-
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
---
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
---
P
Y
----
P
M
Y
P
A
T
T
S
L
V
-
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-------------------------------------------------
312
Blastp_CBE
70.75
53%
-10
- C1 -
-
3PXY
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
174
Blastp_CBE
70.73
53%
-65
- C1 -
-
1URW
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
103
Blastp_CBE
70.74
53%
-14
- C1 -
-
2WEV
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
117
Blastp_CBE
70.73
53%
-56
- C1 -
-
2VTN
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
80
Blastp_CBE
70.73
53%
-12
- C1 -
-
3TI1
9
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
216
Blastp_CBE
70.71
53%
-54
- C1 -
-
1AQ1
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
296
Blastp_CBE
70.69
53%
-12
- C1 -
-
3QTU
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
254
Blastp_CBE
70.66
53%
-11
- C1 -
-
3RJC
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
66
Blastp_CBE
70.65
53%
-56
- C1 -
-
4EK6
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
309
Blastp_CBE
70.63
53%
-4
- C1 -
-
3PY1
4
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
286
Blastp_CBE
70.61
53%
-13
- C1 -
-
3QXP
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
388
Blastp_CBE
70.53
53%
-17
- C1 -
-
4BCM
1
CDK2_HUMAN
C:
[3-297]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
485
Blastp_CBE
70.57
53%
-16
- C1 -
-
3DOG
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
157
Blastp_CBE
70.53
53%
-63
- C1 -
-
2BTS
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
78
Blastp_CBE
70.54
53%
-10
- C1 -
-
3TIZ
9
CDK2_HUMAN
A:
[2-296]
---------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
98
Blastp_CBE
70.53
53%
-16
- C1 -
-
3EID
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
-----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
310
Blastp_CBE
70.48
53%
-10
- C1 -
-
3PY0
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
308
Blastp_CBE
70.52
53%
-11
- C1 -
-
3QL8
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
499
Blastp_CBE
70.39
53%
-19
- C1 -
-
1P5E
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
43
Blastp_CBE
70.51
53%
-57
- C1 -
-
5ANI
1
CDK2_HUMAN
A:
[2-296]
---------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
239
Blastp_CBE
70.50
53%
-12
- C1 -
-
3S00
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
28
Blastp_CBE
70.49
53%
-55
- C1 -
-
3EZR
2
CDK2_HUMAN
A:
[3-298]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
-------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
235
Blastp_CBE
70.48
53%
-12
- C1 -
-
4EZ3
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
13
PsiBlast_PDB
70.44
50%
-18
- C1 -
-
6GU2
1
CDK1_HUMAN
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
------
S
--
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
-
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
------
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
---
N
---
T
F
P
K
W
-
K
P
G
S
L
A
-
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
D
N
Q
I
------------------------------------------
305
Blastp_CBE
70.38
53%
-10
- C1 -
-
3QQH
5
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
23
Blastp_CBE
70.42
57%
-75
- C1 -
-
3O0G
1
CDK5_HUMAN
B:
[6-286]
-------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
K
I
-----
G
T
V
F
K
A
-------
E
I
V
A
L
K
R
V
R
-----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
------
K
--
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
-
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
---
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
---
P
Y
----
P
M
Y
P
A
T
T
S
L
V
-
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-------------------------------------------------
347
Blastp_CBE
70.40
53%
-13
- C1 -
-
6GUC
1
CDK2_HUMAN
A:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
183
Blastp_CBE
70.39
53%
-9
- C1 -
-
1PXJ
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
20
PsiBlast_PDB
70.38
53%
-14
- C1 -
-
6GUE
1
CDK2_HUMAN
A:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
N
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
178
Blastp_CBE
70.37
53%
-11
- C1 -
-
1PXO
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
79
Blastp_CBE
70.35
53%
-12
- C1 -
-
3TIY
13
CDK2_HUMAN
A:
[2-296]
---------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
173
Blastp_CBE
70.33
53%
-62
- C1 -
-
1V1K
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
501
Blastp_CBE
70.30
53%
-11
- C1 -
-
1GY3
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
158
Blastp_CBE
70.27
53%
-56
- C1 -
-
2BTR
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
294
Blastp_CBE
70.25
53%
-13
- C1 -
-
3QTX
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
427
Blastp_CBE
70.24
53%
-54
- C1 -
-
4NJ3
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
348
Blastp_CBE
70.17
53%
-7
- C1 -
-
6GUB
1
?
C:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
------
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
232
Blastp_CBE
70.15
53%
-51
- C1 -
-
6GUH
3
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
478
Blastp_CBE
70.08
53%
-20
- C1 -
-
1JST
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
185
Blastp_CBE
70.05
53%
-13
- C1 -
-
1PF8
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
41
Blastp_CBE
70.01
53%
-62
- C1 -
-
5ANK
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
-----------------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
343
Blastp_CBE
69.97
53%
-9
- C1 -
-
6GUF
1
CDK2_HUMAN
C:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
249
Blastp_CBE
69.96
53%
-9
- C1 -
-
3RM6
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
162
Blastp_CBE
69.93
53%
-12
- C1 -
-
2B54
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
149
Blastp_CBE
69.87
53%
-16
- C1 -
-
2C5X
1
CDK2_HUMAN
C:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
202
Blastp_CBE
69.78
53%
-59
- C1 -
-
1G5S
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
120
Blastp_CBE
69.80
53%
-57
- C1 -
-
2VTJ
2
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
311
Blastp_CBE
69.79
53%
-5
- C1 -
-
3PXZ
3
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
42
Blastp_CBE
69.78
53%
-14
- C1 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-296]
----------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
217
Blastp_CBE
69.73
53%
-60
- C1 -
-
6INL
1
?
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
238
Blastp_CBE
69.59
53%
-13
- C1 -
-
3S0O
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
263
Blastp_CBE
69.56
53%
-13
- C1 -
-
3R8Z
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
--------
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
175
Blastp_CBE
69.53
53%
-60
- C1 -
-
1R78
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
341
Blastp_CBE
69.52
54%
-24
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[1-285]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
-
A
L
K
K
I
R
L
E
-
K
-
E
D
E
-
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
------
K
--
R
-----
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
--
E
-
G
-
G
---
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
----------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
D
---
P
---
N
F
T
V
Y
-
E
P
L
P
W
E
-
S
F
--
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
------------------------------------------------
512
Blastp_CBE
69.43
48%
-63
- C1 -
-
3GC0
1
?
A:
[33-322]
--------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
-
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
-
H
---------
T
A
I
R
E
V
S
L
L
K
E
L
Q
---
H
R
N
I
I
E
L
K
S
V
I
H
------
H
------
N
------
H
--
R
-----
L
H
L
I
F
E
Y
A
E
N
D
L
K
K
Y
M
D
K
---
N
--
P
-
D
-
V
----
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
V
E
-
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
-------------
E
---
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
-
M
K
T
P
L
F
P
G
D
S
E
I
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
P
G
V
T
A
L
P
D
W
K
---
Q
---
S
F
P
K
F
-
R
G
K
T
L
K
-
R
V
L-
G
A
L
-
L
D
D
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
-------------------------------------------------
483
Blastp_CBE
69.37
53%
-9
- C1 -
-
5L2W
2
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
12
PsiBlast_PDB
69.31
50%
-19
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[5-302]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
------
S
--
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
-
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
------
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
---
N
---
T
F
P
K
W
-
K
P
G
S
L
A
-
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
D
N
Q
I
K
K
M
---------------------------------------
363
Blastp_CBE
69.30
53%
-54
- C1 -
-
1GIJ
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
218
Blastp_CBE
69.24
53%
-14
- C1 -
-
3PJ8
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
48
Blastp_CBE
69.15
53%
-15
- C1 -
-
4LYN
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
480
Blastp_CBE
69.01
53%
-16
- C1 -
-
1FQ1
1
CDK2_HUMAN
B:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
111
Blastp_CBE
68.87
53%
-55
- C1 -
-
2VTT
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
345
Blastp_CBE
68.79
53%
-13
- C1 -
-
6GUE
1
CDK2_HUMAN
C:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
-----
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
----
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
10
PsiBlast_PDB
68.66
50%
-17
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[3-294]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
------
S
--
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
-
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
---
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
---
N
---
T
F
P
K
W
-
K
P
G
S
L
A
-
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------
9
PsiBlast_PDB
68.66
50%
-17
- C1 -
-
4Y72
1
CDK1_HUMAN
A:
[3-294]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
------
S
--
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
-
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
---
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
---
N
---
T
F
P
K
W
-
K
P
G
S
L
A
-
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------
342
Blastp_CBE
68.58
53%
-63
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[3-296]
----------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
-
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
557
HHSearch
68.44
40%
-111
- C1 -
-
1UA2
1
CDK7_HUMAN
B:
[13-299]
------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
------
S
--
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
--
S
-
L
-
V
---
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
---
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
---
T
F
----
K
S
F
-
P
G
I
P
L
H
-
H
I
--
F
S
A
-
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
---------------------------------------------
236
Blastp_CBE
68.44
53%
-11
- C1 -
-
3SQQ
2
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
15
PsiBlast_PDB
68.41
50%
-20
- C1 -
-
6GU4
1
CDK1_HUMAN
A:
[3-294]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
------
S
--
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
-
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
---
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
---
N
---
T
F
P
K
W
-
K
P
G
S
L
A
-
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------
16
PsiBlast_PDB
68.28
50%
-19
- C1 -
-
6GU6
1
CDK1_HUMAN
A:
[6-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
------
S
--
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
-
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
-------
T
H
E
---
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
---
N
---
T
F
P
K
W
-
K
P
G
S
L
A
-
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
D
---------------------------------------------
114
Blastp_CBE
68.24
53%
-57
- C1 -
-
2VTQ
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
387
Blastp_CBE
68.01
53%
-5
- C1 -
-
4BCQ
1
CDK2_HUMAN
A:
[2-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
----------------------------------------
139
Blastp_CBE
67.98
53%
-56
- C1 -
-
2DUV
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
105
Blastp_CBE
67.96
53%
-10
- C1 -
-
2W1H
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
14
PsiBlast_PDB
67.93
50%
-17
- C1 -
-
6GU3
1
CDK1_HUMAN
A:
[3-294]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
------
S
--
R
-----
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
-
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
---
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
K
---
N
---
T
F
P
K
W
-
K
P
G
S
L
A
-
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------
187
Blastp_CBE
67.70
53%
-65
- C1 -
-
1OIQ
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
----------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
44
Blastp_CBE
67.65
53%
-59
- C1 -
-
5ANG
1
CDK2_HUMAN
A:
[2-296]
---------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
----------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
87
Blastp_CBE
67.62
53%
-5
- C1 -
-
3LFN
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
164
Blastp_CBE
67.51
53%
-8
- C1 -
-
2B52
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
176
Blastp_CBE
67.44
53%
-64
- C1 -
-
1PYE
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
---------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
186
Blastp_CBE
67.39
53%
-56
- C1 -
-
1P2A
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
4
PsiBlast_PDB
67.36
56%
-23
- C1 -
-
1UNG
1
CDK5_HUMAN
A:
[1-286]
--------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
-
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
------
K
--
K
-----
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
-
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
---
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
---
P
Y
----
P
M
Y
P
A
T
T
S
L
V
-
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-------------------------------------------------
170
Blastp_CBE
67.26
53%
-17
- C1 -
-
1WCC
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
267
Blastp_CBE
67.05
53%
-11
- C1 -
-
3R8M
1
CDK2_HUMAN
A:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
505
Blastp_CBE
66.84
55%
-26
- C1 -
-
4KRC
1
PHO85_YEAST
A:
[7-297]
-----------------------------------------------------------------------------------------------------------------------------------------------
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
-
K
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
-
S
-
E
-
E
-
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
R---------
T
PRG
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
S
S
E
---
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
-
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
PNI
Q
Q
--
R
P
P
R
D
-
L
R
Q
V
L
Q
-
P
H
--
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
-------------------------------------------------
40
Blastp_CBE
66.75
53%
-59
- C1 -
-
5D1J
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
-----------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
39
Blastp_CBE
66.47
53%
-54
- C1 -
-
5FP5
3
CDK2_HUMAN
A:
[1-295]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
----------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
----------------------------------------
515
Blastp_CBE
66.29
41%
-103
- C1 -
-
1UA2
1
CDK7_HUMAN
B:
[13-295]
------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
------
S
--
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
--
S
-
L
-
V
---
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
---
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
---
T
F
K-
S
F
P
G
I
----
P
L
H
-
H
I
--
F
S
A
-
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
-------------------------------------------------
421
Blastp_CBE
66.11
53%
-26
- C1 -
-
4EOJ
1
CDK2_HUMAN
C:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
------------------------
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
38
Blastp_CBE
65.86
53%
-12
- C1 -
-
5FP6
2
CDK2_HUMAN
A:
[1-294]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
365
Blastp_CBE
65.52
53%
-29
- C1 -
-
4EOQ
1
CDK2_HUMAN
C:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
318
Blastp_CBE
65.43
53%
-12
- C1 -
-
5OO1
1
CDK2_HUMAN
A:
[9-301]
-----------------------------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
513
Blastp_CBE
65.06
41%
-101
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-295]
------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
------
S
--
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
--
S
-
L
-
V
---
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
---
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
---
T
F
K-
S
F
P
G
I
----
P
L
H
-
H
I
--
F
S
A
-
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
-------------------------------------------------
516
Blastp_CBE
64.95
41%
-100
- C1 -
-
1UA2
1
CDK7_HUMAN
A:
[13-295]
------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
------
S
--
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
--
S
-
L
-
V
---
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
---
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
---
T
F
K-
S
F
P
G
I
----
P
L
H
-
H
I
--
F
S
A
-
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
-------------------------------------------------
69
Blastp_CBE
64.75
53%
-55
- C1 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-295]
----------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
----------------
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
----------------------------------------
382
Blastp_CBE
64.60
53%
-22
- C1 -
-
3BHU
1
CDK2_HUMAN
C:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
507
Blastp_CBE
64.48
55%
-35
- C1 -
-
2PMI
2
PHO85_YEAST
A:
[19-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
V
Y
K
G
L
N
-
K
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
-
S
-
E
-
E
-
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
RT-
V
--
G
-
N
-
T
PRG
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
S
S
E
---
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
-
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
PNI
Q
Q
--
R
P
P
R
D
-
L
R
Q
V
L
Q
-
P
H
--
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
-------------------------------------------------
380
Blastp_CBE
64.06
53%
-21
- C1 -
-
3BHV
1
CDK2_HUMAN
C:
[1-298]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
514
Blastp_CBE
63.97
41%
-102
- C1 -
-
1UA2
1
CDK7_HUMAN
C:
[13-295]
------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
------
S
--
N
-----
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
--
S
-
L
-
V
---
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
T
H
Q
---
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
---
T
F
K-
S
F
P
G
I
----
P
L
H
-
H
I
--
F
S
A
-
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
-------------------------------------------------
449
Blastp_CBE
63.83
53%
-24
- C1 -
-
4EOM
1
CDK2_HUMAN
C:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
419
Blastp_CBE
63.92
53%
-23
- C1 -
-
4CFU
1
CDK2_HUMAN
C:
[4-301]
----------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
409
Blastp_CBE
63.83
53%
-23
- C1 -
-
2IW9
1
CDK2_HUMAN
C:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
------------------------------------
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
358
Blastp_CBE
63.43
53%
-21
- C1 -
-
1OGU
1
CDK2_HUMAN
C:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------
P
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
431
Blastp_CBE
63.35
53%
-62
- C1 -
-
2R3N
1
CDK2_HUMAN
A:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
370
Blastp_CBE
63.21
53%
-21
- C1 -
-
4BCO
1
CDK2_HUMAN
C:
[2-298]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
384
Blastp_CBE
62.96
53%
-22
- C1 -
-
3BHT
1
CDK2_HUMAN
C:
[2-298]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
461
Blastp_CBE
62.87
53%
-25
- C1 -
-
4EOR
1
CDK2_HUMAN
C:
[2-295]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
-----------------------------------------
398
Blastp_CBE
62.60
53%
-28
- C1 -
-
4CFM
1
CDK2_HUMAN
C:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------------------------------------
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
490
Blastp_CBE
62.20
53%
-20
- C1 -
-
2G9X
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
378
Blastp_CBE
61.63
53%
-25
- C1 -
-
3MY5
1
CDK2_HUMAN
C:
[2-298]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
--------------------------------------
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
354
Blastp_CBE
61.63
53%
-22
- C1 -
-
1OIU
1
CDK2_HUMAN
C:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-----------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
456
Blastp_CBE
61.62
53%
-25
- C1 -
-
5LMK
1
?
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-----------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
338
Blastp_CBE
61.55
53%
-25
- C1 -
-
2IW8
1
CDK2_HUMAN
C:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-----------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
368
Blastp_CBE
61.48
53%
-20
- C1 -
-
4BCP
1
CDK2_HUMAN
C:
[2-298]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
484
Blastp_CBE
61.12
53%
-23
- C1 -
-
3DOG
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
417
Blastp_CBE
60.88
53%
-24
- C1 -
-
4CFV
1
CDK2_HUMAN
C:
[5-301]
-----------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
486
Blastp_CBE
60.51
53%
-23
- C1 -
-
3DDQ
1
CDK2_HUMAN
C:
[2-297]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-----------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
519
Blastp_CBE
59.45
43%
-5
- C1 -
-
1XO2
1
CDK6_HUMAN
B:
[11-303]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
-
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
------
S
----------RETK-
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G
---
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
-----
A
L
T
S
V
---
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
------
Q
--
A
F
H
----
A
Q
P
I
E
-
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
----------------------------------------------
554
HHSearch
58.85
37%
-10
- C1 -
-
4IC7
1
MK07_HUMAN
A:
[54-355]
--------------------------------------------------------------------------------------------------------------------------------------------
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
-
F
-
D
V
V
-
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
R
------
P
TVPYGE
F
------
K
--
S
-----
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
---
S
----
Q
-
P
---
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
-
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
-
V
R
---
A
Y
IQ
S
L
P
P
R
-
Q
P
V
P
W
E
-
T
V
--
Y
P
G
-
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
-------------------------------------------
565
HHSearch
58.76
37%
-10
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[6-306]
---------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
-
F
-
D
-
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
R
PTVPYG
E
------
F
------
K
--
S
-----
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
---
S
----
Q
-
P
---
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
-
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
-
V
R
---
A
Y
IQ
S
L
P
P
R
-
Q
P
V
P
W
E
-
T
V
--
Y
P
G
-
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
-------------------------------------------
518
Blastp_CBE
58.20
43%
-1
- C1 -
-
2EUF
2
CDK6_HUMAN
B:
[11-303]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
-
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
------
S
------
R
--
T
DRETK
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G
---
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
-----
A
L
T
S
V
---
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
-----------------------
A
Q
P
I
E
-
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
----------------------------------------------
558
HHSearch
57.85
37%
-10
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[7-307]
---------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
-
F
-
D
V
V
-
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
R
PTVPYG
E
------
F
------
K
--
S
-----
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
---
S
----
Q
-
P
---
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
-
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
-
V
R
---
A
Y
IQ
S
L
P
P
R
-
Q
P
V
P
W
E
-
T
V
--
Y
P
G
-
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
-------------------------------------------
517
Blastp_CBE
56.42
43%
4
- C1 -
-
2F2C
2
CDK6_HUMAN
B:
[11-303]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
-
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
-
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
------
S
---------
T
DRETK
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G
---
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
-----
A
L
T
S
V
---
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
-------------
Q
--
A
F
-----
A
Q
P
I
E
-
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
----------------------------------------------
563
HHSearch
55.08
32%
-20
- C1 -
-
1J1B
1
GSK3B_HUMAN
A:
[54-345]
---------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
-
K
--------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
---
H
C
N
I
V
R
L
R
Y
F
F
Y
------
S
------
S
GEKKDE
V
--
Y
-----
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
YSR
A
--
K
-
Q
-
T
---
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
-
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-----
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
-
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
T
---
E
F
--
K
F
P
Q
I
-
K
A
H
P
W
T
K
V
F
--
R
P
R
-
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
--------------------------------------------
525
Blastp_CBE
54.47
43%
-14
- C1 -
-
5L2S
1
CDK6_HUMAN
A:
[11-301]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
-------------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G
---
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
------
Q
--
A
F
H
S
K
-
S
A
Q
P
I
E
-
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
------------------------------------------------
455
Blastp_CBE
54.21
53%
-19
- C1 -
-
1H01
3
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
-
I
R
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
526
Blastp_CBE
54.18
43%
-12
- C1 -
-
5L2I
1
CDK6_HUMAN
A:
[11-301]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
-----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
-------------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G
---
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
------
Q
--
A
F
--
K
-
S
A
Q
P
I
E
-
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
------------------------------------------------
524
Blastp_CBE
52.87
43%
-9
- C1 -
-
5L2T
1
CDK6_HUMAN
A:
[11-301]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
------------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
-------------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G
---
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
------
Q
--
A
F
H
S
K
-
S
A
Q
P
I
E
-
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
------------------------------------------------
527
Blastp_CBE
52.76
43%
-11
- C1 -
-
4EZ5
1
CDK6_HUMAN
A:
[11-301]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
------------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
-------------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G
---
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
------
Q
--
A
F
H
---
S
A
Q
P
I
E
-
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
------------------------------------------------
534
Blastp_CBE
52.67
40%
-5
- C1 -
-
4BCF
1
CDK9_HUMAN
A:
[16-318]
-----------------------------------------------------------------------------------------------------------------------------------------
E
--
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
-
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
-
N
-
E
K
E
-
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
---
H
E
N
V
V
N
L
I
E
I
C
R
------
T
------
K
------
A
--
S
-----
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
---
V
--
L
-
V
-
K
---
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
-
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
---------
P
N
R
YNR
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
E
L
Y
E
---
K
L
--
E
L
V
K
G
-
Q
K
R
K
V
K
-
D
R
LK
A
Y
V
-
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
-----------------------------------------------
529
Blastp_CBE
52.56
43%
-9
- C1 -
-
3NUX
1
CDK6_HUMAN
A:
[11-301]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
-----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
-------------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G
---
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
------
Q
--
A
F
H
-
K
-
S
A
Q
P
I
E
-
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
------------------------------------------------
454
Blastp_CBE
52.46
53%
-16
- C1 -
-
1OIR
1
CDK2_HUMAN
A:
[1-296]
--------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
-
I
R
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
------
N
--
K
-----
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
-
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
---
P
---
S
F
P
K
W
-
A
R
Q
D
F
S
-
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
H
L
---------------------------------------
532
Blastp_CBE
52.42
38%
-9
- C1 -
-
5EFQ
2
CDK13_HUMAN
A:
[3-309]
-------------------------------------------------------------------------------------------------------------------------------------
I
D
W
G
K
RC
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
-
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
-
N
-
E
K
E
-
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
---
H
Q
S
I
I
N
M
K
E
I
V
-------
T
------
D
------
K
EG
A
-----
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
--
L
-
V
-
H
---
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
Y
N
K
---
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
---
T
M
--
K
P
K
K
Q
-
Y
R
R
K
L
R
-
E
E
--
F
V
F
-
I
P
A
A
A
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
R
D
V
----------------------------------------------
530
Blastp_CBE
51.90
43%
-15
- C1 -
-
3NUP
1
CDK6_HUMAN
A:
[12-300]
----------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
-------------
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
-----------------K----
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G
---
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
------
Q
--
A
F
H
---
S
A
Q
P
I
E
-
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
-------------------------------------------------
531
Blastp_CBE
51.76
38%
-9
- C1 -
-
5EFQ
2
C:
[5-309]
---------------------------------------------------------------------------------------------------------------------------------------
W
G
K
RC
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
-
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
-
N
-
E
K
E
-
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
---
H
Q
S
I
I
N
M
K
E
I
V
-------
T
------
D
------
K
EG
A
-----
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
--
L
-
V
-
H
---
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
Y
N
K
---
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
---
T
M
--
K
P
K
K
Q
-
Y
R
R
K
L
R
-
E
E
--
F
V
F
-
I
P
A
A
A
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
R
D
V
----------------------------------------------
520
Blastp_CBE
50.95
43%
-2
- C1 -
-
4TTH
1
CDK6_HUMAN
B:
[15-303]
-------------------------------------------------------------------------------------------------------------------------------------------------
C
V
A
E
I
G
E
----
K
V
F
K
A
R
D
L
K
N
-
G
R
F
V
A
L
K
R
V
R
V
------
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
-
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
-
Q
M
----
A
L
T
S
V
---
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
-------------------------
P
I
E
-
K
F
----
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
----------------------------------------------
528
Blastp_CBE
49.81
43%
-5
- C1 -
-
4AUA
1
CDK6_HUMAN
A:
[11-301]
---------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
---------------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
-------------------------TK---
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G
---
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
----------------------
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
P
R
------
Q
--
A
F
H
S
K
-
S
A
Q
P
I
E
-
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------