@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK19_HUMAN: (2021-11-22 )
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
Atome Classification :
(504 SA)
.........10........20....-....30........40...---.....50.-..----....----.60........70........80......----.----.90........100.......110.......120-.......130.......140.......150.......-160.......170.......180....-...190.......200.......210.......220.......230........240.......250.......260.......270....-.--..280.......290-.........300..--.....310.......320.......330.....--..340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDYD
F
K
A
K
L
A
A
E
R
E
R
V
E
D
L
F
E
YEGC-KVGRGTYG
H
V
Y
K
A
RRKDGK---
D
E
K
E
Y
A
L
K
-
Q
I----EGTG----I
S
M
S
A
C
R
E
I
A
L
L
R
E
LKHP
N
V
I
A
L
Q
K
V
F
LS----H----SD
R
K
V
W
L
L
F
DYAE
H
D
L
W
H
I
I
K
F
H
RASKANKK
P
M
Q
-
L
P
R
S
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
HA
N
W
V
L
HRDLKPA
N
I
L
V
-MGEGPERG
R
V
K
I
A
D
M
G
F
A
R
L
FNSPLKP-LADLD
P
V
V
V
T
F
W
YR
A
P
E
L
L
L
GARH
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
LTS-EP
I
F
H
C
R
QEDIKTSNPF
H
H
D
Q
L
D
R
I
F
S
V
MGFPADK
D
W
E
D
I
R
KMPEY-P--
T
L
Q
K
D
F
R
R
TTYA
N
---
S
S
L
I
K
Y
M
E
K
HKVKP--D
S
K
V
F
L
L
L
Q
K
L
LTMDPTKRI
T
S
E
Q
ALQDPYFQE--DPL
P
T
L
D
V
FAGCQIPY
P
K
R
E
FLNEDDPEEKGD
K
N
Q
Q
Q
Q
Q
N
QHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
551
HHSearch
97.07
92%
-112
- C3 -
-
5XS2
2
CDK8_HUMAN
A:
[10-372]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
N
K
K
P
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
P
-
L
A
D
L
D
P
V
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
D
I
K
T
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.83
91%
-112
- C3 -
-
5XS2
2
CDK8_HUMAN
A:
[10-372]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
N
K
K
P
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
P
-
L
A
D
L
D
P
V
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
D
I
K
T
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
94.99
93%
-131
- C3 -
-
5HBH
3
CDK8_HUMAN
A:
[3-363]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
-------
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
---------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
------
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
93.72
93%
-136
- C3 -
-
5FGK
10
CDK8_HUMAN
A:
[3-364]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
-------
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
------------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
-------
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
--------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
93.71
91%
-121
- C3 -
-
5HNB
6
CDK8_HUMAN
A:
[4-362]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
-------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
-----------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
93.33
92%
-116
- C3 -
-
5IDP
3
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-----
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
-----------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
---
T
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
93.24
93%
-127
- C3 -
-
5HBJ
2
CDK8_HUMAN
A:
[3-363]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
----
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
--
L
F
N
S
P
L
-----------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
-----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
93.21
93%
-118
- C3 -
-
5ICP
7
CDK8_HUMAN
A:
[3-364]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
--------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
---------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
--------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
92.91
92%
-125
- C3 -
-
5IDN
5
CDK8_HUMAN
A:
[3-365]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
N
------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
-----------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
E
-------------------------------------------------------------------------------------------------------------------------------------------
552
HHSearch
92.83
92%
-115
- C3 -
-
5I5Z
2
CDK8_HUMAN
A:
[4-365]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
N
------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
-----------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
-----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
--------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
92.80
93%
-117
- C3 -
-
5HBE
4
CDK8_HUMAN
A:
[3-363]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
N
----
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
----------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
-----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------
553
HHSearch
92.66
93%
-118
- C3 -
-
5ICP
7
CDK8_HUMAN
A:
[3-363]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
--------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
---------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
92.61
91%
-115
- C3 -
-
5I5Z
2
CDK8_HUMAN
A:
[4-365]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
N
------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
-----------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
-----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
--------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
92.61
87%
-115
- C3 -
-
5CEI
9
CDK8_HUMAN
A:
[4-365]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
-----
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
P
----------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
--------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.38
91%
-124
- C3 -
-
5XQX
3
CDK8_HUMAN
A:
[10-371]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
---------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
--------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
----
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
--------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
92.24
87%
-124
- C3 -
-
4CRL
4
CDK8_HUMAN
A:
[4-362]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
------
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
-----------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
-------
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
91.73
87%
-125
- C3 -
-
4G6L
1
CDK8_HUMAN
A:
[4-362]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
---------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
-------------
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
------
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
91.33
87%
-120
- C3 -
-
4F7S
8
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
------
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
K
P
----------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
-----
T
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
90.88
87%
-115
- C3 -
-
5BNJ
3
CDK8_HUMAN
A:
[3-364]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
N
----
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
F
N
S
P
L
------------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
E
--------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
90.39
87%
-130
- C3 -
-
5HVY
2
CDK8_HUMAN
A:
[4-362]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
----
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
------
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
L
-------------
P
V
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
----
K
T
S
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
550
HHSearch
90.31
92%
-118
- C3 -
-
4F6U
10
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-----
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
-----
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
90.19
87%
-118
- C3 -
-
4F6W
10
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-----
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
-------------------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.98
87%
-123
- C3 -
-
4F6S
6
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
---------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
------------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
-------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
89.91
87%
-125
- C3 -
-
4F7N
2
CDK8_HUMAN
A:
[3-363]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
------
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
-----
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
89.44
87%
-121
- C3 -
-
4F7L
1
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
-------
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
---------------------
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
89.27
87%
-126
- C3 -
-
4F70
1
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
A
-------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
---------------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
-------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.21
87%
-118
- C3 -
-
4F6U
10
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
-----
V
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
E
-----
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.03
87%
-135
- C3 -
-
3RGF
6
CDK8_HUMAN
A:
[3-355]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
-----
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
A
S
K
--------
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
A
R
-----------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.03
87%
-124
- C3 -
-
4F7J
3
CDK8_HUMAN
A:
[3-361]
M
D
Y
D
F
K
V
K
L
S
S
E
R
E
R
V
E
D
L
F
E
Y
E
G
C
-
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
D
G
K
---
D
D
K
D
Y
A
L
K
-
Q
I
----
E
G
T
G
----
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
----
H
----
A
D
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
K
F
H
R
---------
Q
-
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
-
M
G
E
G
P
E
R
G
R
V
K
I
A
D
M
G
F
-------------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
S
-
E
P
I
F
H
C
R
Q
------
N
P
Y
H
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
K
M
P
E
H
-
S
--
T
L
M
K
D
F
R
R
N
T
Y
T
N
---
C
S
L
I
K
Y
M
E
K
H
K
V
K
P
--
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
E
--
D
P
L
P
T
S
D
V
F
A
G
C
Q
I
P
Y
P
K
R
E
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
65.57
40%
-97
- C3 -
-
3NS9
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
65.55
40%
-98
- C3 -
-
1PXL
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
65.06
40%
-98
- C3 -
-
2C5Y
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
64.99
40%
-100
- C3 -
-
2R3O
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
64.64
40%
-98
- C3 -
-
1E1X
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
64.24
40%
-95
- C3 -
-
2R3H
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
64.07
40%
-96
- C3 -
-
1B38
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
64.04
40%
-96
- C3 -
-
2R3G
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
63.91
40%
-99
- C3 -
-
4EK5
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
63.89
40%
-94
- C3 -
-
1JSV
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
63.88
40%
-98
- C3 -
-
2R3R
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
63.87
40%
-94
- C3 -
-
1PXK
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
63.81
40%
-99
- C3 -
-
4D1X
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
63.78
40%
-92
- C3 -
-
1E1V
2
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
63.75
40%
-99
- C3 -
-
2R3P
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
63.68
40%
-97
- C3 -
-
1B39
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
63.67
40%
-98
- C3 -
-
4FKL
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
63.61
40%
-97
- C3 -
-
2R3Q
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
63.60
40%
-99
- C3 -
-
2R3F
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
63.47
40%
-95
- C3 -
-
6Q3F
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
63.46
40%
-93
- C3 -
-
2A4L
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
----------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
63.43
40%
-101
- C3 -
-
2VTI
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
63.21
40%
-91
- C3 -
-
1PXM
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
63.19
40%
-97
- C3 -
-
3IGG
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
63.12
40%
-90
- C3 -
-
2VTL
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
63.09
40%
-97
- C3 -
-
2R3I
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
63.08
40%
-102
- C3 -
-
1CKP
2
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
62.96
40%
-102
- C3 -
-
2R64
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
62.96
40%
-100
- C3 -
-
2VTP
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
62.86
40%
-95
- C3 -
-
4EK4
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
62.85
40%
-95
- C3 -
-
1H08
2
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
--------
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
62.67
40%
-101
- C3 -
-
3SW4
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
62.54
40%
-94
- C3 -
-
3LE6
1
CDK2_HUMAN
A:
[9-294]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
62.36
40%
-94
- C3 -
-
4FKG
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
62.32
40%
-100
- C3 -
-
4FKP
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
62.15
40%
-96
- C3 -
-
3S2P
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
62.12
40%
-94
- C3 -
-
1VYZ
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
62.03
40%
-100
- C3 -
-
3IG7
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
61.81
40%
-97
- C3 -
-
5JQ8
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
61.77
40%
-94
- C3 -
-
4FKT
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
61.65
40%
-97
- C3 -
-
5AND
1
CDK2_HUMAN
A:
[9-294]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
61.60
40%
-95
- C3 -
-
4EK8
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
61.15
40%
-96
- C3 -
-
4FKJ
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
61.01
40%
-97
- C3 -
-
1GII
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
---
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
60.91
40%
-95
- C3 -
-
4BGH
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
60.81
40%
-90
- C3 -
-
2BTR
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
60.77
40%
-90
- C3 -
-
2UZN
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
60.74
40%
-94
- C3 -
-
4EK6
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
--------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
60.69
40%
-98
- C3 -
-
1H00
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
60.57
40%
-94
- C3 -
-
2R3J
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
60.48
40%
-92
- C3 -
-
1OIT
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
60.43
40%
-93
- C3 -
-
2DUV
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-----------------
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
60.42
40%
-88
- C3 -
-
2B55
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
60.30
40%
-95
* C3 *
-
2R3M
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
60.07
40%
-92
- C3 -
-
2R3K
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
60.04
40%
-93
- C3 -
-
2BHH
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
59.99
40%
-90
- C3 -
-
4FKS
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
59.91
40%
-95
- C3 -
-
1URW
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
59.70
40%
-92
- C3 -
-
1DM2
5
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
59.55
40%
-93
- C3 -
-
2VTT
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
59.49
40%
-88
- C3 -
-
6INL
1
?
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
59.19
40%
-88
- C3 -
-
1AQ1
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
59.11
40%
-31
- C3 -
-
3UNK
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R---
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
58.87
40%
-40
- C3 -
-
3PY0
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
58.69
40%
-35
- C3 -
-
3R1S
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
58.67
40%
-33
- C3 -
-
3TIZ
9
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
58.59
40%
-36
- C3 -
-
3R1Y
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
58.49
40%
-42
- C3 -
-
4EZ3
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
58.45
40%
-34
- C3 -
-
3QQJ
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
58.35
40%
-35
- C3 -
-
3QZH
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
58.36
40%
-35
- C3 -
-
3R6X
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
58.35
40%
-34
- C3 -
-
3R28
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
58.26
38%
-85
- C3 -
-
4AU8
2
CDK5_HUMAN
A:
[13-292]
--------------------------
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
-----
T
H
E
I
V
A
L
K
-
R
-------------
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
-------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
---
K
Y
F
D
S
C
N
G
D
L
D
P
------
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
----
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
---
S
---
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
---------
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
-
K
--
P
Y
P
-----
M
Y
P
A
T
---
T
S
L
V
N
V
V
P
K
L
N
A
T
G
--
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
58.15
40%
-34
- C3 -
-
3R83
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
58.09
40%
-97
- C3 -
-
1PYE
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
--
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
58.09
40%
-36
- C3 -
-
3QTQ
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
58.08
40%
-34
- C3 -
-
3R73
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
58.04
40%
-36
- C3 -
-
1PXO
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
57.95
40%
-32
- C3 -
-
1PXP
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
57.95
40%
-31
- C3 -
-
2A0C
1
CDK2_HUMAN
X:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
57.88
40%
-34
- C3 -
-
1HCK
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
57.92
40%
-35
- C3 -
-
5ANE
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
57.87
40%
-35
- C3 -
-
3QL8
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
57.86
40%
-36
- C3 -
-
3TIY
13
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
57.89
40%
-36
- C3 -
-
3QZI
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
57.88
40%
-31
- C3 -
-
3S00
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
57.87
40%
-35
- C3 -
-
3QQF
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
57.86
40%
-36
- C3 -
-
3RJC
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
57.85
40%
-33
- C3 -
-
3QQH
5
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
57.82
40%
-36
- C3 -
-
3R7E
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
57.73
40%
-32
- C3 -
-
3RK5
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
57.74
40%
-34
- C3 -
-
3QZG
3
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
57.73
40%
-33
- C3 -
-
3RM7
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
57.67
40%
-33
- C3 -
-
1PXI
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
57.67
40%
-32
- C3 -
-
3QQG
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
57.70
40%
-37
- C3 -
-
3R8Z
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
57.68
40%
-30
- C3 -
-
3R8U
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
57.67
40%
-32
- C3 -
-
3R8V
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
57.65
40%
-94
- C3 -
-
5FP5
3
CDK2_HUMAN
A:
[9-295]
--------------------------
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
---
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
57.60
40%
-33
- C3 -
-
3PXY
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
57.63
40%
-32
- C3 -
-
3R71
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
57.58
40%
-36
- C3 -
-
3RAI
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
57.60
40%
-34
- C3 -
-
3R1Q
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
57.58
40%
-34
- C3 -
-
3RPO
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
57.52
40%
-95
- C3 -
-
1OIQ
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
---------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
---
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
57.52
40%
-32
- C3 -
-
1PXJ
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
57.52
40%
-35
- C3 -
-
3QTX
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
57.50
40%
-36
- C3 -
-
3RNI
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
57.49
40%
-34
- C3 -
-
3RK9
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
57.46
40%
-34
- C3 -
-
3ROY
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
57.44
40%
-35
- C3 -
-
3QX2
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
57.43
40%
-32
- C3 -
-
3R7V
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
57.39
40%
-31
- C3 -
-
3QU0
4
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
57.36
40%
-36
- C3 -
-
3QZF
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
57.29
40%
-31
- C3 -
-
3PJ8
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R---
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
57.32
40%
-38
- C3 -
-
2C6L
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
57.29
40%
-36
- C3 -
-
3QWK
5
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
57.29
40%
-32
- C3 -
-
3R8P
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
57.30
40%
-43
- C3 -
-
1WCC
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
57.29
40%
-33
- C3 -
-
3RK7
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
57.27
40%
-33
- C3 -
-
3R8L
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
57.23
40%
-37
- C3 -
-
1DI8
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
57.21
40%
-36
- C3 -
-
3QXP
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
57.16
40%
-37
- C3 -
-
3UNJ
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
57.11
40%
-25
- C3 -
-
2XNB
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
57.09
40%
-34
- C3 -
-
1PXN
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
57.05
40%
-34
- C3 -
-
3TI1
9
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
57.00
40%
-21
- C3 -
-
4FX3
2
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
56.97
40%
-37
- C3 -
-
1W8C
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
56.96
40%
-21
- C3 -
-
1VYW
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
56.94
40%
-34
- C3 -
-
3QQK
6
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
56.91
40%
-92
- C3 -
-
4D1Z
2
CDK2_HUMAN
A:
[9-295]
--------------------------
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
----------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
---------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
56.90
40%
-21
- C3 -
-
2BKZ
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
56.86
40%
-23
- C3 -
-
4FX3
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
56.77
40%
-19
- C3 -
-
2WIH
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
56.83
40%
-22
- C3 -
-
2BKZ
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
56.81
40%
-92
- C3 -
-
5ANG
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
--------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
---
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
56.80
40%
-30
- C3 -
-
3R7Y
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
56.79
40%
-18
- C3 -
-
2WPA
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
56.74
40%
-39
- C3 -
-
2VTS
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
56.77
40%
-34
- C3 -
-
3RPV
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
56.74
40%
-34
- C3 -
-
3QTZ
3
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
56.60
40%
-33
- C3 -
-
6Q3C
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
56.64
40%
-31
- C3 -
-
3QRT
3
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
56.61
40%
-76
- C3 -
-
6GUC
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
56.60
40%
-45
- C3 -
-
1KE9
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
56.51
40%
-23
- C3 -
-
3F5X
2
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
56.57
40%
-31
- C3 -
-
3LFS
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
56.56
40%
-36
- C3 -
-
3LFQ
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
56.55
40%
-35
- C3 -
-
3R7U
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
56.54
40%
-32
- C3 -
-
3R9D
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
56.50
40%
-36
- C3 -
-
3QWJ
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
56.52
40%
-77
- C3 -
-
6GUE
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
-----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
N
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
56.51
40%
-35
- C3 -
-
4FKI
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
56.43
40%
-19
- C3 -
-
2BPM
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
56.50
40%
-28
- C3 -
-
3QXO
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
56.46
40%
-9
- C3 -
-
2EXM
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
56.41
40%
-16
- C3 -
-
3F5X
2
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
56.43
40%
-29
- C3 -
-
2B53
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
56.42
40%
-36
- C3 -
-
1H0V
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
56.35
40%
-20
- C3 -
-
2WPA
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
56.41
40%
-89
- C3 -
-
5D1J
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
------------------
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
56.37
40%
-18
- C3 -
-
2UUE
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
56.32
40%
-31
- C3 -
-
2VTR
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
56.36
40%
-16
- C3 -
-
2C5N
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
56.28
39%
-38
- C3 -
-
3NIZ
1
?
A:
[28-309]
--------------------------
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
G
R
---
I
---
V
A
L
K
-
R
I
R------
G
----
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
------
H
----
S
E
R
C
L
T
L
V
F
E
F
M
E
K
D
L
------
K
K
V
L
D
E
N
K
T
G
L
Q
---
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
S
D
G
A
----
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
H
---
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
-
K
P
L
F
P
G
V
T
D
D
---------
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
-
K
QR
T
F
Q
V
-
F
E
K
K
P
W
-----
S
S
I
I
P
G
F
C
Q
E
G
I
D
---------
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L-
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
56.35
40%
-37
- C3 -
-
3R7I
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
56.27
40%
-22
- C3 -
-
2WXV
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
56.33
40%
-21
- C3 -
-
2WXV
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
56.32
40%
-16
- C3 -
-
2X1N
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
56.28
40%
-39
- C3 -
-
3FZ1
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
--------
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
56.28
40%
-31
- C3 -
-
3QQL
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
56.27
40%
-18
- C3 -
-
2C5V
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
56.24
40%
-35
- C3 -
-
3QTW
7
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
56.21
40%
-18
- C3 -
-
2C5O
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
56.21
40%
-17
- C3 -
-
2WEV
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
56.24
40%
-33
- C3 -
-
3QX4
3
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
56.23
40%
-37
- C3 -
-
5JQ5
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
56.21
40%
-21
- C3 -
-
3EOC
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
56.12
40%
-41
- C3 -
-
1KE5
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
56.16
40%
-30
- C3 -
-
3R9H
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
56.12
40%
-35
- C3 -
-
3RKB
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
56.10
40%
-18
- C3 -
-
2BPM
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
56.05
40%
-34
- C3 -
-
3QTS
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
55.97
40%
-41
- C3 -
-
1KE7
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
55.96
40%
-21
- C3 -
-
6Q4C
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
55.94
40%
-14
- C3 -
-
2WEV
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
55.88
40%
-19
- C3 -
-
2UUE
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
55.90
40%
-17
- C3 -
-
2C4G
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
55.89
40%
-16
- C3 -
-
2C5N
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
55.88
40%
-11
- C3 -
-
5ANJ
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
55.87
40%
-23
- C3 -
-
2C6M
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
55.86
40%
-29
- C3 -
-
3RM6
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
55.84
40%
-32
- C3 -
-
6Q4H
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
55.82
40%
-33
- C3 -
-
3QTU
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
55.81
40%
-17
- C3 -
-
2XMY
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT---
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
55.80
38%
-81
- C3 -
-
1UA2
1
CDK7_HUMAN
D:
[18-310]
---------------------------
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
-----
T
N
Q
I
V
A
I
K
-
K
-------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
H
----
K
----
S
N
--
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
--------
D
N
S
L
V
-
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
-----
D
E
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
A
-
Y
H
Q
----
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
-
V
P
-
F
L
P
G
D
S
D
L
--------
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
------------
V
T
F
K
S
---
F
P
G
I
P
L
H
H
I
F
S
A
A
G
--
D
D
-
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
--
R
P
G
P
T
----
P
G
C
Q
L
P
R
P
----------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
55.79
40%
-17
- C3 -
-
1FIN
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
55.77
40%
-40
- C3 -
-
3ULI
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
55.69
40%
-18
- C3 -
-
2C4G
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
55.75
40%
-18
- C3 -
-
2C5V
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
55.74
40%
-34
- C3 -
-
3RAH
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
55.69
40%
-43
- C3 -
-
1W0X
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
55.68
40%
-19
- C3 -
-
2V0D
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
55.61
40%
-36
- C3 -
-
6Q4G
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
55.57
40%
-18
- C3 -
-
2WIH
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
55.57
40%
-17
- C3 -
-
1FVV
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
55.61
40%
-19
- C3 -
-
4FKU
3
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
55.60
40%
-20
- C3 -
-
2I40
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
55.55
40%
-37
- C3 -
-
2VTO
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
55.52
40%
-35
- C3 -
-
1H0W
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
55.53
40%
-21
- C3 -
-
2C68
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
55.50
40%
-91
- C3 -
-
2R3N
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
------------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
55.57
40%
-20
- C3 -
-
3EID
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
-----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
55.56
40%
-18
- C3 -
-
2C6O
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
55.55
40%
-33
- C3 -
-
3R9N
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
55.54
40%
-19
- C3 -
-
2B54
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
55.53
40%
-29
- C3 -
-
3LFN
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
----------
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
55.52
40%
-33
- C3 -
-
3RPR
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
55.51
40%
-20
- C3 -
-
2C6I
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
55.50
40%
-20
- C3 -
-
3EJ1
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
55.45
40%
-9
- C3 -
-
4KD1
2
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
55.42
40%
-17
- C3 -
-
2C6K
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
55.45
40%
-30
- C3 -
-
3SQQ
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
------
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
55.38
40%
-36
- C3 -
-
1FVT
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
55.43
40%
-38
- C3 -
-
1KE8
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
55.42
40%
-19
- C3 -
-
2UZO
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
55.40
40%
-30
- C3 -
-
2W1H
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
55.38
40%
-17
- C3 -
-
2C69
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
55.37
40%
-22
- C3 -
-
2CLX
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
55.36
40%
-15
- C3 -
-
2C5O
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
55.33
40%
-17
- C3 -
-
1VYW
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
55.24
40%
-41
- C3 -
-
5ANI
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
55.26
40%
-34
- C3 -
-
5A14
2
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
55.25
39%
-31
- C3 -
-
5MHQ
1
?
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
V
A
L
K
I
R
L-----------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
55.24
40%
-18
- C3 -
-
6Q4B
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
55.22
40%
-26
- C3 -
-
3PXQ
4
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
55.18
40%
-18
- C3 -
-
1FVV
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
55.15
40%
-14
- C3 -
-
3QRU
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
55.10
40%
-14
- C3 -
-
2X1N
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
55.09
40%
-21
- C3 -
-
5IEX
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
55.08
40%
-42
- C3 -
-
2VTH
2
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
55.04
40%
-22
- C3 -
-
5IEV
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
54.97
40%
-36
- C3 -
-
3R8M
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
54.94
40%
-42
- C3 -
-
1KE6
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
54.92
40%
-18
- C3 -
-
1Y8Y
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
54.90
40%
-29
- C3 -
-
2B52
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R----
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
------------
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
54.88
40%
-16
- C3 -
-
2C5X
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
54.86
40%
-24
- C3 -
-
6Q4I
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---
L
----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
54.85
40%
-9
- C3 -
-
3PXZ
3
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
54.83
40%
-14
- C3 -
-
1FIN
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
54.76
40%
-8
- C3 -
-
3PXF
7
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
54.76
40%
-16
- C3 -
-
4EZ7
7
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
54.68
40%
-13
- C3 -
-
1YKR
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
54.64
40%
-14
- C3 -
-
4GCJ
5
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
54.63
40%
-18
- C3 -
-
2I40
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
54.62
40%
-19
- C3 -
-
3EJ1
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
54.57
40%
-37
- C3 -
-
3RAL
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
54.54
40%
-34
- C3 -
-
2W06
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
54.51
40%
-20
- C3 -
-
3S0O
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
54.50
40%
-14
- C3 -
-
6Q4F
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
54.48
40%
-32
- C3 -
-
3R9O
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
54.47
40%
-24
- C3 -
-
6Q4A
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
54.38
40%
-17
- C3 -
-
2C5X
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
54.42
40%
-36
- C3 -
-
6GUK
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
54.38
40%
-33
- C3 -
-
3QTR
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
54.38
40%
-23
- C3 -
-
6Q4J
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
54.14
40%
-21
- C3 -
-
4FKO
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
54.12
40%
-11
- C3 -
-
6Q4D
6
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
54.11
40%
-36
- C3 -
-
3RAK
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
54.09
40%
-20
- C3 -
-
4FKQ
2
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
54.08
40%
-19
- C3 -
-
3WBL
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
53.99
40%
-32
- C3 -
-
1GIH
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
54.04
40%
-35
- C3 -
-
3RPY
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
54.03
40%
-17
- C3 -
-
5IEY
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
54.02
40%
-14
- C3 -
-
3PY1
4
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
53.99
40%
-13
- C3 -
-
1PF8
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
53.94
40%
-33
- C3 -
-
1H07
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
----
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
53.85
40%
-37
- C3 -
-
2J9M
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
53.84
40%
-36
- C3 -
-
3S1H
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
53.82
40%
-17
- C3 -
-
4FKR
2
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
53.74
40%
-39
- C3 -
-
5K4J
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
53.71
40%
-16
- C3 -
-
4LYN
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
53.68
40%
-21
- C3 -
-
6Q48
2
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
53.56
40%
-32
- C3 -
-
2VTN
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
53.56
40%
-18
- C3 -
-
6Q4E
3
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
53.55
40%
-34
- C3 -
-
3RZB
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
53.47
40%
-25
- C3 -
-
4FKW
2
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
53.38
40%
-41
- C3 -
-
5ANK
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
--------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
53.34
40%
-37
- C3 -
-
2VTJ
2
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
53.28
40%
-18
- C3 -
-
1Y91
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
------
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
53.06
40%
-34
- C3 -
-
3EZV
1
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
53.04
38%
-23
- C3 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-286]
--------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
G
E
---
T
---
F
A
L
K
-
K
I
RL--------------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
------
H
----
T
K
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
---------
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
R
E
G
----
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
K
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
-
T
P
L
F
P
G
V
S
E
---------
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
--------
D
P
N
F
T
V
Y
E
P
LPW
E
S
F
L
K
G
L
D
E
S
G
I
D
---------
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
52.92
40%
-41
- C3 -
-
2W17
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
52.89
40%
-19
- C3 -
-
2FVD
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------------
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
--
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
52.86
40%
-32
- C3 -
-
2R3L
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
52.83
40%
-33
- C3 -
-
2W05
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
52.70
40%
-32
- C3 -
-
4ACM
3
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
--
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
52.67
40%
-20
- C3 -
-
2VU3
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
----
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
52.66
40%
-19
- C3 -
-
3RMF
1
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
52.60
40%
-35
- C3 -
-
2BTS
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
52.59
40%
-23
- C3 -
-
2VV9
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
52.46
40%
-28
- C3 -
-
1GIJ
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R---------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
---
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
52.53
40%
-27
- C3 -
-
4BCP
1
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
52.43
40%
-34
- C3 -
-
1G5S
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
52.46
40%
-30
- C3 -
-
4EOR
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
52.43
40%
-24
- C3 -
-
3DDQ
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
52.31
40%
-26
- C3 -
-
3SW7
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
52.25
40%
-31
- C3 -
-
2VTQ
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
52.25
40%
-26
- C3 -
-
5LMK
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
52.20
40%
-29
- C3 -
-
4EOM
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL--
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
52.20
40%
-23
- C3 -
-
3BHU
1
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
52.19
40%
-23
- C3 -
-
4BZD
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
52.15
40%
-14
- C3 -
-
5OO1
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
52.14
38%
-18
- C3 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-286]
--------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
G
E
---
T
---
F
A
L
K
-
K
I
RL------------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
------
H
----
T
K
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
---------
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
R
E
G
----
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
K
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
-
T
P
L
F
P
G
V
S
E
---------
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
--------
D
P
N
F
T
V
Y
E
P
LPW
E
S
F
L
K
G
L
D
E
S
G
I
D
---------
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
52.07
40%
-19
- C3 -
-
4FKV
2
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-----
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
51.94
40%
-20
- C3 -
-
4NJ3
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
51.94
40%
-27
- C3 -
-
4CFV
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
51.82
40%
-26
- C3 -
-
4CFW
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
51.80
40%
-30
- C3 -
-
2CCI
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
51.78
40%
-28
- C3 -
-
4EOO
1
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
51.67
40%
-28
- C3 -
-
4EOL
1
CDK2_HUMAN
A:
[12-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL--
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
D
F
M
D
A
S
-
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
51.66
40%
-31
- C3 -
-
4BCM
1
CDK2_HUMAN
A:
[12-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
51.54
40%
-34
- C3 -
-
4EOK
1
CDK2_HUMAN
A:
[12-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
D
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
554
HHSearch
51.59
32%
-22
- C3 -
-
4IC7
1
MK07_HUMAN
A:
[60-354]
-----------------------
I
E
-
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
-----
T
G
Q
Q
V
A
I
K
-
K
I
----
P
N
A
F
DVVT
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
----
T
VPYG
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
---------
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
-
N
E
----
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
-
R
Q
L
F
P
G
K
N
Y
---------
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
-
V
-
R
--
A
Y
I
Q
S
L
P
P
R
--
Q
P
---
V
P
----
W
E
T
V
Y
P
G
A
--
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
--
Y
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
51.57
40%
-30
- C3 -
-
3TNW
1
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
51.57
40%
-21
- C3 -
-
4CFU
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
51.56
40%
-29
- C3 -
-
2IW9
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
51.54
40%
-23
- C3 -
-
2G9X
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
51.52
40%
-27
- C3 -
-
2UZL
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
51.42
40%
-21
- C3 -
-
1R78
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
51.44
40%
-32
- C3 -
-
4EOJ
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
D
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
51.43
40%
-22
- C3 -
-
1H1S
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
51.42
40%
-22
- C3 -
-
3BHT
1
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
51.40
40%
-28
- C3 -
-
3EZR
2
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
R-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
51.40
40%
-19
- C3 -
-
1H1R
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
51.34
40%
-23
- C3 -
-
4CFN
1
CDK2_HUMAN
C:
[13-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
51.33
40%
-32
- C3 -
-
4CFN
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
51.31
40%
-25
- C3 -
-
1H1P
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
51.31
40%
-26
- C3 -
-
6GUB
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
51.26
40%
-29
- C3 -
-
3QHW
3
CDK2_HUMAN
C:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
51.22
40%
-28
- C3 -
-
3QHR
2
CDK2_HUMAN
C:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
51.22
40%
-28
- C3 -
-
4EOQ
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
51.21
40%
-24
- C3 -
-
4CFX
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
51.18
40%
-23
- C3 -
-
4BCO
1
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
51.16
40%
-25
- C3 -
-
5NEV
1
CDK2_HUMAN
A:
[14-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
51.15
40%
-29
- C3 -
-
1OGU
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
51.13
40%
-23
- C3 -
-
6GUF
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
51.12
40%
-18
- C3 -
-
4EOS
1
CDK2_HUMAN
C:
[12-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
51.11
40%
-21
- C3 -
-
4EON
1
CDK2_HUMAN
C:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
51.09
40%
-18
- C3 -
-
1P2A
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL--------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
51.00
40%
-27
- C3 -
-
3MY5
3
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
51.00
40%
-20
- C3 -
-
4BCN
1
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
50.97
40%
-27
- C3 -
-
2CCH
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
50.95
40%
-28
- C3 -
-
4BCM
1
CDK2_HUMAN
C:
[12-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
50.93
40%
-28
- C3 -
-
4II5
3
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
50.90
40%
-23
- C3 -
-
1P5E
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
50.89
40%
-22
- C3 -
-
2C6T
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
50.88
40%
-27
- C3 -
-
1OIU
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
50.84
40%
-24
- C3 -
-
4I3Z
4
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
50.84
40%
-24
- C3 -
-
4EOO
1
CDK2_HUMAN
C:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
50.83
40%
-26
- C3 -
-
3QHR
6
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
50.82
40%
-27
- C3 -
-
1OIY
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
50.80
40%
-27
- C3 -
-
3QHW
2
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
50.80
40%
-19
- C3 -
-
1E9H
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
50.79
40%
-23
- C3 -
-
4I3Z
3
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
50.76
40%
-20
- C3 -
-
3BHV
2
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
50.76
40%
-18
- C3 -
-
1E9H
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
50.75
40%
-27
- C3 -
-
1OI9
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
50.72
40%
-19
- C3 -
-
3DDP
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
50.71
40%
-23
- C3 -
-
1H1R
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
50.69
40%
-27
- C3 -
-
5CYI
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
50.67
40%
-29
- C3 -
-
6GUF
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
50.64
40%
-22
- C3 -
-
1H1Q
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
50.65
40%
-24
- C3 -
-
3DDP
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
50.64
40%
-27
- C3 -
-
1PKD
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
50.62
40%
-20
- C3 -
-
4EON
1
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
50.60
40%
-28
- C3 -
-
4II5
2
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
50.60
40%
-24
- C3 -
-
1QMZ
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
50.55
40%
-14
- C3 -
-
6GUH
3
CDK2_HUMAN
A:
[17-304]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
--------
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
50.57
40%
-26
- C3 -
-
2CCH
3
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
50.55
40%
-29
- C3 -
-
4BCK
2
CDK2_HUMAN
A:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
50.54
40%
-23
- C3 -
-
1H1S
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
50.53
40%
-22
- C3 -
-
3DOG
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLT-
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
50.51
40%
-15
- C3 -
-
1V1K
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
50.50
40%
-27
- C3 -
-
4EOK
1
CDK2_HUMAN
C:
[12-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
D
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
50.48
40%
-27
- C3 -
-
4EOI
2
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL----
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
D
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
50.47
40%
-26
- C3 -
-
2UZD
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
50.43
40%
-23
- C3 -
-
1H1P
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
50.40
40%
-24
- C3 -
-
4CFW
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
50.39
40%
-22
- C3 -
-
2UZL
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
50.36
40%
-23
- C3 -
-
1H1Q
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
50.35
40%
-17
- C3 -
-
1OI9
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLT-
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
50.33
40%
-21
- C3 -
-
2C6T
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
50.33
40%
-21
- C3 -
-
4EOP
1
CDK2_HUMAN
C:
[12-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
50.30
40%
-23
- C3 -
-
4CFM
1
CDK2_HUMAN
A:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
50.28
40%
-24
- C3 -
-
5CYI
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
50.28
40%
-25
- C3 -
-
4BCQ
1
CDK2_HUMAN
A:
[9-298]
--------------------------
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
50.28
40%
-24
- C3 -
-
4EOP
1
CDK2_HUMAN
A:
[12-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
50.27
40%
-25
- C3 -
-
1JST
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
50.25
40%
-23
- C3 -
-
4BCN
1
CDK2_HUMAN
C:
[11-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
50.23
40%
-24
- C3 -
-
4CFX
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
50.23
40%
-26
- C3 -
-
6GUB
1
?
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
--------------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
50.21
37%
7
- C3 -
-
1V0P
1
CDC2H_PLAFK
A:
[3-286]
--------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
G
E
---
T
---
F
A
L
K
-
K
I
RLEK
E
D
E
G
----
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
------
H
----
T
K
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
---------
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
R
E
G
----
E
L
K
I
A
D
F
G
L
A
R
A
F
G
-------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
-
T
P
L
F
P
G
V
S
E
---------
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
--------
D
P
N
F
T
V
Y
E
P
LPW
E
S
F
L
K
G
L
D
E
S
G
I
D
---------
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
50.20
40%
-17
- C3 -
-
4EOI
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
D
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
50.19
40%
-18
- C3 -
-
5NEV
1
?
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
50.15
38%
-8
- C3 -
-
4AU8
2
CDK5_HUMAN
B:
[13-292]
--------------------------
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
-----
T
H
E
I
V
A
L
K
-
R
V
RL----
E
G
----
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
----
S
-
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
---
K
Y
F
D
S
C
N
G
D
L
D
P
------
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
----
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
----------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
---------
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
-
K
--
P
Y
P
-----
M
Y
P
A
T
---
T
S
L
V
N
V
V
P
K
L
N
A
T
G
--
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
50.12
40%
-26
- C3 -
-
2IW6
1
CDK2_HUMAN
C:
[13-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
50.08
36%
-8
- C3 -
-
4KRC
1
PHO85_YEAST
A:
[12-299]
--------------------------
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
K
T
T
G
VYV
A
L
K
E
V
K
L
D
-
S
E
----
E
G
T
------
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
------
H
----
T
E
N
K
L
T
L
V
F
E
F
M
D
N
D
L
---
K
K
Y
M
D
S
R
----
T
P
R
G
-
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
-----
N
K
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
T
-
F
S
S
---
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
G
-
K
P
L
F
P
G
T
N
D
E
---------
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
V
T
K
L
P
K
Y
N
P
--
N
I
Q
Q
R
P
P
R
---------
D
L
R
Q
V
L
Q
P
H
T
K
E
P
L-
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
50.06
40%
-20
- C3 -
-
1OIY
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
50.04
40%
-20
- C3 -
-
4EOL
1
CDK2_HUMAN
C:
[12-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
D
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
50.03
40%
-22
- C3 -
-
2IW8
1
CDK2_HUMAN
A:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
49.99
40%
-25
- C3 -
-
4BCK
1
CDK2_HUMAN
C:
[11-296]
--------------------------
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
49.98
40%
-25
- C3 -
-
4EOS
1
CDK2_HUMAN
A:
[12-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD---
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
49.97
40%
-24
- C3 -
-
6GUC
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
49.95
40%
-22
- C3 -
-
2UZE
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
49.94
40%
-15
- C3 -
-
1P5E
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
49.91
40%
-21
- C3 -
-
2UZD
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
49.92
40%
-10
- C3 -
-
5FP6
2
CDK2_HUMAN
A:
[9-294]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
49.91
40%
-22
- C3 -
-
2UZE
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
49.83
40%
-24
- C3 -
-
5L2W
2
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
49.83
40%
-26
- C3 -
-
6GUE
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
-----
T
S
M
P
D
Y
K
P
--
S
F
P
K
---
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
49.82
40%
-25
- C3 -
-
6GVA
3
CDK2_HUMAN
A:
[10-291]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLD--
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
49.73
37%
5
- C3 -
-
1UNL
1
CDK5_HUMAN
A:
[9-288]
--------------------------
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
-----
H
E
I
V
A
L
K
-
R
V
RLDD
D
D
E
G
----
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
----
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
---
K
Y
F
D
S
C
N
G
D
L
D
P
------
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
----
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
C
-
Y
S
---
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
---------
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
-
K
--
P
Y
P
-----
M
Y
P
A
T
---
T
S
L
V
N
V
V
P
K
L
N
A
T
G
--
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
49.63
40%
-19
- C3 -
-
2UZB
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
49.60
40%
-20
- C3 -
-
1QMZ
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
49.55
40%
-27
- C3 -
-
2IW6
1
CDK2_HUMAN
A:
[13-299]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RL---
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
49.53
40%
-20
- C3 -
-
1GY3
2
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
49.48
40%
-19
- C3 -
-
1JST
1
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
49.46
40%
-19
- C3 -
-
2UZB
1
CDK2_HUMAN
C:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
49.41
40%
-18
- C3 -
-
3TNW
1
CDK2_HUMAN
C:
[11-296]
--------------------------
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
49.37
40%
-22
- C3 -
-
4BCQ
1
CDK2_HUMAN
C:
[12-297]
--------------------------
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
49.35
40%
-29
- C3 -
-
2CCI
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
49.29
38%
-2
- C3 -
-
4YC3
1
CDK1_HUMAN
A:
[14-294]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
--
T
---
T
G
Q
V
V
A
M
K
-
K
I
RLES
E
E
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
----------
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
-------
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-----
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
V
-
Y
T
------
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
---------
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
-
K
--
N
T
F
P
K
W
K
P
G
S
L
A
S
------------
H
V
K
N
L
--
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
49.27
38%
0
- C3 -
-
6GU2
1
CDK1_HUMAN
A:
[14-294]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
--
T
---
T
G
Q
V
V
A
M
K
-
K
I
RLES
E
E
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
----------
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
-------
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-----
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
V
-
Y
T
------
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
---------
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
-
K
--
N
T
F
P
K
W
K
P
G
S
L
A
S
------------
H
V
K
N
L
--
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
49.26
38%
8
- C3 -
-
6GU3
1
CDK1_HUMAN
A:
[14-294]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
--
T
---
T
G
Q
V
V
A
M
K
-
K
I
RLES
E
E
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
----------
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
-------
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-----
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
V
-
Y
T
H
---
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
---------
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
-
K
--
N
T
F
P
K
W
K
P
G
S
L
A
S
------------
H
V
K
N
L
--
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
48.99
38%
3
- C3 -
-
6GU4
1
CDK1_HUMAN
A:
[14-294]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
--
T
---
T
G
Q
V
V
A
M
K
-
K
I
RLES
E
E
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
----------
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
-------
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-----
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
V
-
Y
T
H
---
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
---------
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
-
K
--
N
T
F
P
K
W
K
P
G
S
L
A
S
------------
H
V
K
N
L
--
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
48.98
40%
-19
- C3 -
-
1GY3
1
CDK2_HUMAN
A:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
48.87
38%
7
- C3 -
-
4Y72
1
CDK1_HUMAN
A:
[14-294]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
--
T
---
T
G
Q
V
V
A
M
K
-
K
I
RLES
E
E
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
----------
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
-------
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-----
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
V
-
Y
T
H
---
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
---------
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
-
K
--
N
T
F
P
K
W
K
P
G
S
L
A
S
------------
H
V
K
N
L
--
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
48.87
38%
7
- C3 -
-
5HQ0
1
CDK1_HUMAN
A:
[14-294]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
--
T
---
T
G
Q
V
V
A
M
K
-
K
I
RLES
E
E
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
----------
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
-------
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-----
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
V
-
Y
T
H
---
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
---------
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
-
K
--
N
T
F
P
K
W
K
P
G
S
L
A
S
------------
H
V
K
N
L
--
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
48.65
40%
-26
- C3 -
-
2G9X
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-----------------------------------------
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
48.48
40%
-17
- C3 -
-
1PKD
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
48.38
36%
-1
- C3 -
-
3GC0
1
?
A:
[41-325]
--------------------------
K
L
G
E
G
T
Y
G
E
V
Y
K
A
--
I
D
T
V
---
T
N
E
T
V
A
I
K
-
R
I
RLEH-----------
T
A
I
R
E
V
S
L
L
K
E
L
Q
H
R
N
I
I
E
L
K
S
V
I
------
H
----
H
N
H
R
L
H
L
I
F
E
Y
A
E
N
D
L
---------
K
K
Y
M
D
K
N
P
D
-
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
V
----
E
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
-------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
K
-
T
P
L
F
P
G
D
S
E
I
---------
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
P
G
V
T
A
L
P
D
W
-
K
--
Q
S
F
P
K
F
R
G
K
T
L
K
R
---
V
L
--------
G
A
L
L
--
D
D
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
S
H
--
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
567
HHSearch
48.25
32%
-14
- C3 -
-
5BYZ
7
MK07_HUMAN
A:
[12-305]
------------------------
E
-
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
-----
T
G
Q
Q
V
A
I
K
-
K
I
----
P
N
A
F
DVVT
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
TVPY
G
----
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
---------
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
-
N
E
----
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
-
R
Q
L
F
P
G
K
N
Y
---------
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
--
R
--
A
Y
I
Q
S
L
P
P
R
Q
---------
P
V
P
W
E
T
V
Y
P
G
A
--
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
--
Y
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
48.20
37%
-25
- C3 -
-
1V0P
1
CDC2H_PLAFK
B:
[3-286]
--------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
G
E
---
T
---
F
A
L
K
----------------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
------
H
----
T
---
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
E
G
G
---------
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
R
E
G
----
E
L
K
I
A
D
F
G
L
A
R
A
F
-----------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
-
T
P
L
F
P
G
V
S
E
---------
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
P
K
Y
--------
D
P
N
F
T
V
Y
E
P
LPW
E
S
F
L
K
G
L
D
E
S
G
I
D
---------
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
48.10
40%
-17
- C3 -
-
1FQ1
1
CDK2_HUMAN
B:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
47.87
40%
-27
- C3 -
-
1OGU
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
47.86
38%
5
- C3 -
-
6GU6
1
CDK1_HUMAN
A:
[14-294]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
--
T
---
T
G
Q
V
V
A
M
K
-
K
I
RLES
E
E
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
Q
----------
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
-------
K
K
Y
L
D
S
I
P
P
G
Q
Y
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-----
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
----
T
H
---
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
---------
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
Y
-
K
--
N
T
F
P
K
W
K
P
G
S
L
A
S
------------
H
V
K
N
L
--
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
47.69
37%
10
- C3 -
-
1UNG
1
CDK5_HUMAN
A:
[5-288]
--------------------------
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
-----
H
E
I
V
A
L
K
-
R
V
RLDD
D
D
E
G
----
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
----
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
---
K
Y
F
D
S
C
N
G
D
L
D
P
------
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
----
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
C
-
Y
S
---
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
---------
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
-
K
--
P
Y
P
-----
M
Y
P
A
T
---
T
S
L
V
N
V
V
P
K
L
N
A
T
G
--
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
47.67
40%
-26
- C3 -
-
3BHU
1
CDK2_HUMAN
C:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
47.65
40%
-25
- C3 -
-
4BCO
1
CDK2_HUMAN
C:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
--------------------------------------------
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
47.62
40%
-23
- C3 -
-
4EOJ
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
D
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
----------------------------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
47.57
40%
-26
- C3 -
-
3DOG
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------------
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
47.38
40%
-28
- C3 -
-
3BHV
1
CDK2_HUMAN
C:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
47.28
40%
-26
- C3 -
-
3BHT
1
CDK2_HUMAN
C:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
557
HHSearch
47.06
32%
-16
- C3 -
-
4B99
1
MK07_HUMAN
A:
[60-353]
------------------------
E
-
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
-----
T
G
Q
Q
V
A
I
K
-
K
I
----
P
N
A
F
DVVT
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
----
T
VPYG
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
---------
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
-
N
E
----
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
-------
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
-
R
Q
L
F
P
G
K
N
Y
---------
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
------
R
V
-
R
--
A
Y
I
Q
S
L
P
P
---------
R
Q
P
V
P
W
E
T
V
Y
P
G
A
--
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
--
Y
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
47.02
40%
-25
- C3 -
-
4EOR
1
CDK2_HUMAN
C:
[10-295]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-----------------------------------------
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
46.85
40%
-24
- C3 -
-
4CFU
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
46.74
40%
-30
- C3 -
-
3DDQ
1
CDK2_HUMAN
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
46.63
40%
-19
- C3 -
-
4EOQ
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
46.58
40%
-25
- C3 -
-
5LMK
1
?
C:
[10-297]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
46.55
40%
-31
- C3 -
-
4CFM
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-----------------------------------------------PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
46.34
40%
-20
- C3 -
-
2IW8
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
46.19
37%
-11
- C3 -
-
1UNG
1
CDK5_HUMAN
B:
[2-287]
--------------------------
K
I
G
E
G
T
Y
G
T
V
F
K
A
------------
I
V
A
L
K
-
R
V
RLD----
G
----
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
----
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
---
K
Y
F
D
S
C
N
G
D
L
D
P
------
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
----
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
C
-
Y
S
---
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
---------
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
-
K
--
P
Y
P
-----
M
Y
P
A
T
---
T
S
L
V
N
V
V
P
K
L
N
A
T
G
--
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
46.16
40%
-23
- C3 -
-
4BCP
1
CDK2_HUMAN
C:
[11-298]
--------------------------
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
46.01
40%
-21
- C3 -
-
4EOM
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
45.83
40%
-34
- C3 -
-
4CFV
1
CDK2_HUMAN
C:
[14-301]
--------------------------
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------------
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
45.71
40%
-27
- C3 -
-
3MY5
1
CDK2_HUMAN
C:
[11-298]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
45.69
40%
-27
- C3 -
-
1OIU
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
45.58
40%
-21
- C3 -
-
2IW9
1
CDK2_HUMAN
C:
[13-300]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
---------------------------------------------
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
42.74
39%
-13
- C3 -
-
4RJ3
1
CDK2_HUMAN
A:
[9-295]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
V
A
L
K
I
R
L
D
T
----
E
-----------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
37.93
39%
-3
- C3 -
-
1H01
3
CDK2_HUMAN
A:
[9-296]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
V
A
L
K
I
R
----------
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
34.36
40%
6
- C3 -
-
2WIP
1
CDK2_HUMAN
C:
[5-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
33.08
40%
8
- C3 -
-
2WIP
1
CDK2_HUMAN
A:
[2-301]
--------------------------
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
---
E
V
--
V
A
L
K
-
K
I
RLDT
E
T
E
G
----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
----
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
-
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
-
N
T
E
G
A
----
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-
Y
T
H
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
I
---------
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
--
S
F
P
K
W
A
R
Q
---------------
D
F
S
K
V
V
P
PL
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
VT
K
P
V
P
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------