@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDKL3_HUMAN: (2021-11-22 )
MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRVIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKENPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQEDPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGMEVKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW
Atome Classification :
(509 SA)
.........10........20........30..-......-40...-......50........60........70-----.------...---.....80-------....---.....90--..---.---------.--.--...100.......110.......120.......130.......140.......150...----..---..160.......170.......180.......190...-....200.......210.......----220---....------....230.....-..240..--...-..--250----....-.--------------....260---........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
M
Y
E
T
L
GKVGEGSYG
T
V
M
K
C
KHKNT
G
Q
I
V
A
I
K
-
I
F
Y
ER
P
-
E
-
Q
S
V
-
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
------Q------KK
K
---
I
H
L
V
F
E
--------
F
I
D
H
---
T
V
L
D
E
L
Q
--
H
Y
---
C
---------H--G--L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
HSNNIIHRDIKPE
N
I
L
VSQSG
I
T
K
L
C
DFG
F
A
RTLAAPG
D
----
I
Y
---
T
D
Y
V
A
T
R
WYRAP
E
L
V
L
KDTSYGKP
V
D
I
W
A
L
G
C
M
I
I
E
MA-TGNPYLPSSS
D
L
D
L
L
H
K
I
V
L
K
VGN----L
S
----
P
H
L
Q
------
N
I
FSKSP
I
F
A
G
V
-VLPQVQH--
P
K
N
-
A
R
--
K
------KYP
K
-
L
--------------
N
G
L
L
A
D
----
I
V
H
A
C
LQI
D
P
A
DRISSSD
L
L
H
H
E
YFTRDG
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
N
S
LIKPKESS
K
E
N
E
L
R
K
D
ER
K
T
V
Y
T
N
T
L
L
S
S
S
V
L
G
K
E
I
E
KEKKPK
E
I
K
V
R
V
I
K
V
KGGRGDISEP
K
K
K
E
YEGGLGQQDANENVHPMSPDT
K
L
V
T
IEPPNPINPSTNCNGLKENPHCGG
S
V
TMPPINLTNSN
L
M
A
ANLSSNLFHPS
V
R
L
T
E
R
A
K
KRRTSS
Q
S
I
G
Q
VMPNSRQEDPG
P
I
Q
S
Q
M
E
KGIFNERTGHS
D
Q
MANENKRKLNFSRSDRKEFHFPEL
P
V
T
I
QSKDTKG
M
E
V
K
Q
I
K
M
L
K
R
E
SKKTESSKI
P
T
L
L
NVDQN
Q
E
KQEGGDGHCEGKNLKRNRFFFW
535
HHSearch
97.07
99%
-132
- C3 -
-
3ZDU
3
CDKL3_HUMAN
A:
[2-310]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
I
K
-
I
F
Y
----------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
------
Q
------
K
K
K
---
I
H
L
V
F
E
--------
F
I
D
H
---
T
V
L
D
E
L
Q
--
H
Y
---
C
---------
H
--
G
--
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
----
I
Y
---
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
-
T
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
K
V
G
N
----
L
S
----
P
H
L
Q
------
N
I
F
S
K
S
P
I
F
A
G
V
-
V
L
P
Q
V
Q
H
--
P
K
N
-
A
R
--
K
------
K
Y
P
K
-
L
--------------
N
G
L
L
A
D
----
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.07
99%
-132
- C3 -
-
3ZDU
3
CDKL3_HUMAN
A:
[2-310]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
I
K
-
I
F
Y
----------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
------
Q
------
K
K
K
---
I
H
L
V
F
E
--------
F
I
D
H
---
T
V
L
D
E
L
Q
--
H
Y
---
C
---------
H
--
G
--
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
----
I
Y
---
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
-
T
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
K
V
G
N
----
L
S
----
P
H
L
Q
------
N
I
F
S
K
S
P
I
F
A
G
V
-
V
L
P
Q
V
Q
H
--
P
K
N
-
A
R
--
K
------
K
Y
P
K
-
L
--------------
N
G
L
L
A
D
----
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
81.72
57%
-144
- C3 -
-
4BBM
3
CDKL2_HUMAN
B:
[24-331]
M
E
K
Y
E
N
L
-----
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
-
K
F
-----------
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
---------------------
Y
L
V
F
E
--------
F
V
D
H
---
T
I
L
D
D
L
E
--
L
F
---
P
---------
N
--
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
----
V
Y
---
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
----
L
I
----
P
R
H
Q
------
E
L
F
N
K
N
P
V
F
A
G
V
-
R
L
P
E
I
K
E
--
R
E
P
-
L
E
--
R
------
R
Y
P
K
-
L
--------------
S
E
V
V
I
D
----
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
HHSearch
77.92
58%
-55
- C3 -
-
4BBM
3
CDKL2_HUMAN
A:
[25-327]
-
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
-
K
F
L
E
S
D
D
D
-
K
M
V
-
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
------
K
------
K
K
R
---
W
Y
L
V
F
E
--------
F
V
D
H
---
T
I
L
D
D
L
E
--
L
F
---
P
---------
N
--
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
----
V
Y
---
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
----
L
I
----
P
R
H
Q
------
E
L
F
N
K
N
P
V
F
A
G
V
-
R
L
P
E
I
K
E
--
R
E
P
-
L
E
--
R
------
R
Y
P
K
-
L
--------------
S
E
V
V
I
D
----
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.37
57%
-56
- C3 -
-
4BBM
3
CDKL2_HUMAN
A:
[24-331]
M
E
K
Y
E
N
L
G
L
V
--
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
-
K
F
L
E
S
D
-
D
D
K
M
V
-
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
------
K
------
K
K
R
---
W
Y
L
V
F
E
--------
F
V
D
H
---
T
I
L
D
D
L
E
--
L
F
---
P
---------
N
--
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
----
V
Y
---
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
----
L
I
----
P
R
H
Q
------
E
L
F
N
K
N
P
V
F
A
G
V
-
R
L
P
E
I
K
E
--
R
E
P
-
L
E
--
R
------
R
Y
P
K
-
L
--------------
S
E
V
V
I
D
----
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
HHSearch
75.98
58%
-50
- C3 -
-
4AAA
7
CDKL2_HUMAN
A:
[25-325]
-
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
-
K
F
L
E
S
D
D
D
-
K
M
V
-
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
------
K
------
K
K
R
---
W
Y
L
V
F
E
--------
F
V
D
H
---
T
I
L
D
D
L
E
--
L
F
---
P
---------
N
--
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
-------------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
----
L
I
----
P
R
H
Q
------
E
L
F
N
K
N
P
V
F
A
G
V
-
R
L
P
E
I
K
E
--
R
E
P
-
L
E
--
R
------
R
Y
P
K
-
L
--------------
S
E
V
V
I
D
----
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.66
57%
-52
- C3 -
-
4AAA
7
CDKL2_HUMAN
A:
[24-325]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
-
K
F
L
E
S
D
-
D
D
K
M
V
-
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
------
K
------
K
K
R
---
W
Y
L
V
F
E
--------
F
V
D
H
---
T
I
L
D
D
L
E
--
L
F
---
P
---------
N
--
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
-------------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
N
----
L
I
----
P
R
H
Q
------
E
L
F
N
K
N
P
V
F
A
G
V
-
R
L
P
E
I
K
E
--
R
E
P
-
L
E
--
R
------
R
Y
P
K
-
L
--------------
S
E
V
V
I
D
----
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.24
42%
-119
- C3 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-298]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
-
K
F
K
--------
V
-
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
------
R
------
R
G
K
---
L
Y
L
V
F
E
--------
Y
V
E
K
---
N
M
L
E
L
L
E
--
E
M
---
P
---------
N
--
G
--
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-----------------
T
R
W
Y
R
S
P
E
L
L
L
-
G
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
-
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
----
L
P
----
S
E
Q
M
------
K
L
F
Y
S
N
P
R
F
H
G
L
-
R
F
P
A
V
N
H
--
P
Q
S
-
L
E
--
R
------
R
Y
L
G
I
L
--------------
N
S
V
L
L
D
----
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
HHSearch
73.65
42%
-116
- C3 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-301]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
-
K
F
K
--------
V
-
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
------
R
------
R
G
K
---
L
Y
L
V
F
E
--------
Y
V
E
K
---
N
M
L
E
L
L
E
--
E
M
---
P
---------
N
--
G
--
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-----------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
-
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
P
----
L
P
----
S
E
Q
M
------
K
L
F
Y
S
N
P
R
F
H
G
L
-
R
F
P
A
V
N
H
--
P
Q
S
L
E
R
--
R
------
Y
L
G
I
-
L
--------------
N
S
V
L
L
D
----
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
HHSearch
71.80
49%
-50
- C3 -
-
4AGU
1
CDKL1_HUMAN
C:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
-
K
F
L
E
S
E
D
D
-
P
V
I
-
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
------
R
------
K
R
R
---
L
H
L
V
F
E
--------
Y
C
D
H
---
T
V
L
H
E
L
D
--
R
Y
---
Q
---------
R
--
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
-------------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
----
L
I
----
P
R
H
Q
------
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
I
P
D
P
E
D
--
M
E
P
-
L
E
--
L
------
K
F
P
N
-
I
--------------
S
Y
P
A
L
G
----
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
70.87
49%
-52
- C3 -
-
4AGU
1
CDKL1_HUMAN
C:
[3-288]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
-
K
F
L
E
S
E
-
D
-
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
------
R
------
K
R
R
---
L
H
L
V
F
E
--------
Y
C
D
H
---
T
V
L
H
E
L
D
--
R
Y
---
Q
---------
R
--
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
-------------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
----
L
I
----
P
R
H
Q
------
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
I
P
D
P
E
D
--
M
E
P
-
L
E
--
L
------
K
F
P
N
-
I
--------------
S
Y
P
A
L
G
----
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
HHSearch
70.05
34%
-120
- C3 -
-
1UA2
1
CDK7_HUMAN
B:
[13-298]
----
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
-
K
----------
I
-
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
------
H
------
K
S
N
---
I
S
L
V
F
D
--------
F
M
E
T
---
D
L
E
V
I
I
K
--
D
N
---
S
---------
L
--
V
--
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
---
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
----
P
T
----
E
E
Q
W
------
P
D
M
C
S
L
P
D
Y
V
T
---
F
K
-
S
F
P
--
G
I
P
-
L
H
--
H
------
I
F
S
A
-
A
--------------
G
D
D
L
L
D
----
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.86
49%
-52
- C3 -
-
4AGU
1
CDKL1_HUMAN
A:
[3-288]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
-
K
F
L
E
S
E
---
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
------
R
------
K
R
R
---
L
H
L
V
F
E
--------
Y
C
D
H
---
T
V
L
H
E
L
D
--
R
Y
---
Q
---------
R
--
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
-------------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
----
L
I
----
P
R
H
Q
------
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
I
P
D
P
E
D
--
M
E
P
-
L
E
--
L
------
K
F
P
N
-
I
--------------
S
Y
P
A
L
G
----
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
HHSearch
69.51
34%
-119
- C3 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-286]
--
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
-
Y
G
E
T
F
A
L
K
-
K
I
R
L
------------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
K
R
---
L
V
L
V
F
E
--------
H
L
D
Q
---
D
L
K
K
L
L
D
--
V
C
---
E
---------
G
--
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
----
P
N
----
S
K
N
W
------
P
N
V
T
E
L
P
K
Y
D
P
--
N
F
-
T
V
Y
E
--
P
L
P
-
W
E
--
S
------
F
L
K
G
-
L
--------------
D
E
S
G
I
D
----
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
69.23
49%
-55
- C3 -
-
4AGU
1
CDKL1_HUMAN
B:
[4-288]
--
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
-
K
F
L
E
S
----
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
------
R
------
K
R
R
---
L
H
L
V
F
E
--------
Y
C
D
H
---
T
V
L
H
E
L
D
--
R
Y
---
Q
---------
R
--
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
-------------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
D
----
L
I
----
P
R
H
Q
------
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
I
P
D
P
E
D
--
M
E
P
-
L
E
--
L
------
K
F
P
N
-
I
--------------
S
Y
P
A
L
G
----
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
553
HHSearch
69.07
34%
-110
- C3 -
-
5G6V
4
CDK16_HUMAN
A:
[1-290]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
-
E
I
R
L
E
H
-
E
-
E
G
A
-
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
K
S
---
L
T
L
V
F
E
--------
Y
L
D
K
---
D
L
K
Q
Y
L
D
--
D
C
---
G
---------
N
--
I
--
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
E
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
---
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
----
P
T
----
E
E
T
W
------
P
G
I
L
S
N
E
E
F
K
T
Y
-
N
Y
P
K
Y
R
---
A
E
A
-
L
L
--
S
------
H
A
P
R
-
L
--------------
D
S
D
G
A
D
----
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
HHSearch
68.17
34%
-120
- C3 -
-
3MTL
-
CDK16_HUMAN
A:
[1-290]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
-
E
I
R
L
---------
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
H
A
N
I
V
T
L
H
D
I
I
H
------
T
------
E
K
S
---
L
T
L
V
F
E
--------
Y
L
D
K
---
D
L
K
Q
Y
L
D
--
D
C
---
G
---------
N
--
I
--
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
E
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
-------------------
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
----
P
T
----
E
E
T
W
------
P
G
I
L
S
N
E
E
F
K
T
Y
-
N
Y
P
K
Y
R
---
A
E
A
-
L
L
--
S
------
H
A
P
R
-
L
--------------
D
S
D
G
A
D
----
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
65.20
37%
-55
- C3 -
-
3NIZ
1
?
A:
[20-304]
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
-
D
S
Q
G
R
I
V
A
L
K
R
I
R
--------
G
I
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
------
S
------
E
R
C
---
L
T
L
V
F
E
--------
F
M
E
K
---
D
L
K
K
V
L
D
--
E
N
---
K
---------
T
--
G
--
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----------
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
----
P
N
----
P
R
E
W
------
P
Q
V
Q
E
L
P
L
W
K
Q
R
-
T
F
-
Q
V
F
E
--
K
K
P
-
W
S
--
S
------
I
I
P
G
-
F
--------------
C
Q
E
G
I
D
----
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
HHSearch
63.05
33%
-18
- C3 -
-
4ZSG
6
MK07_HUMAN
A:
[7-304]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
-
K
I
P
N
A
F
D
V
-
V
T
N
-
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
PTVPYG
E
------
F
K
S
---
V
Y
V
V
L
D
--------
L
M
E
S
---
D
-
L
H
Q
I
I
--
H
S
---
S
---------
Q
--
P
--
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
---
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
----
P
S
----
P
A
V
I
------
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
-
P
R
Q
--
P
V
P
-
W
E
--
T
------
V
Y
P
G
-
A
--------------
D
R
Q
A
L
S
----
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
HHSearch
62.63
33%
-19
- C3 -
-
4IC7
1
MK07_HUMAN
A:
[55-352]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
-
K
I
P
N
A
F
D
V
-
V
T
N
-
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
------
P
TVPYGE
F
K
S
---
V
Y
V
V
L
D
--------
L
M
E
S
---
D
-
L
H
Q
I
I
--
H
S
---
S
---------
Q
--
P
--
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
---
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
----
P
S
----
P
A
V
I
------
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
-
R
Q
--
P
V
P
-
W
E
--
T
------
V
Y
P
G
-
A
--------------
D
R
Q
A
L
S
----
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.56
37%
-27
- C3 -
-
6GU3
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
S
R
---
L
Y
L
I
F
E
--------
F
L
S
M
---
D
L
K
K
Y
L
D
--
S
I
---
P
---------
P
--
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
----
P
N
N
E
-------------------
V
W
P
E
V
E
S
--
L
Q
D
-
Y
K
--
N
------
T
F
P
K
-
W
KPGSLASHVKNLDE
N
G
L
--
D
----
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
62.44
36%
-41
- C3 -
-
1VYW
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.22
37%
-27
- C3 -
-
6GU6
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
S
R
---
L
Y
L
I
F
E
--------
F
L
S
M
---
D
L
K
K
Y
L
D
--
S
I
---
P
---------
P
--
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
----------
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
----
P
N
N
E
-------------------
V
W
P
E
V
E
S
--
L
Q
D
-
Y
K
--
N
------
T
F
P
K
-
W
KPGSLASHVKNLDE
N
G
L
--
D
----
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
62.16
37%
-27
- C3 -
-
6GU4
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
S
R
---
L
Y
L
I
F
E
--------
F
L
S
M
---
D
L
K
K
Y
L
D
--
S
I
---
P
---------
P
--
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
----
P
N
N
E
-------------------
V
W
P
E
V
E
S
--
L
Q
D
-
Y
K
--
N
------
T
F
P
K
-
W
KPGSLASHVKNLDE
N
G
L
--
D
----
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
62.12
36%
-42
- C3 -
-
2C5O
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.08
37%
-29
- C3 -
-
5HQ0
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
S
R
---
L
Y
L
I
F
E
--------
F
L
S
M
---
D
L
K
K
Y
L
D
--
S
I
---
P
---------
P
--
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
----
P
N
N
E
-------------------
V
W
P
E
V
E
S
--
L
Q
D
-
Y
K
--
N
------
T
F
P
K
-
W
KPGSLASHVKNLDE
N
G
L
--
D
----
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.08
37%
-29
- C3 -
-
4Y72
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
S
R
---
L
Y
L
I
F
E
--------
F
L
S
M
---
D
L
K
K
Y
L
D
--
S
I
---
P
---------
P
--
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
----
P
N
N
E
-------------------
V
W
P
E
V
E
S
--
L
Q
D
-
Y
K
--
N
------
T
F
P
K
-
W
KPGSLASHVKNLDE
N
G
L
--
D
----
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.07
37%
-31
- C3 -
-
4YC3
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
S
R
---
L
Y
L
I
F
E
--------
F
L
S
M
---
D
L
K
K
Y
L
D
--
S
I
---
P
---------
P
--
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
----
P
N
N
E
-------------------
V
W
P
E
V
E
S
--
L
Q
D
-
Y
K
--
N
------
T
F
P
K
-
W
KPGSLASHVKNLDE
N
G
L
--
D
----
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
HHSearch
62.05
33%
-18
- C3 -
-
5BYZ
7
MK07_HUMAN
A:
[6-303]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
-
K
I
P
N
A
F
-
D
V
V
T
N
-
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
PTVPYG
E
------
F
K
S
---
V
Y
V
V
L
D
--------
L
M
E
S
---
D
-
L
H
Q
I
I
--
H
S
---
S
---------
Q
--
P
--
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
---
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
----
P
S
----
P
A
V
I
------
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
-
P
R
Q
--
P
V
P
-
W
E
--
T
------
V
Y
P
G
-
A
--------------
D
R
Q
A
L
S
----
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
61.94
36%
-38
- C3 -
-
2UUE
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
61.90
36%
-37
- C3 -
-
2C5N
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
61.85
36%
-37
- C3 -
-
2UUE
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
61.69
36%
-42
- C3 -
-
2WXV
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
61.65
36%
-50
- C3 -
-
3F5X
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
61.61
36%
-41
- C3 -
-
4FX3
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
61.56
36%
-38
- C3 -
-
2C5N
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
61.41
36%
-40
- C3 -
-
1FVV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
61.24
36%
-24
- C3 -
-
1UNL
1
CDK5_HUMAN
A:
[1-287]
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
-
D
-
E
G
V
-
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
K
K
---
L
T
L
V
F
E
--------
F
C
D
Q
-------
D
L
K
--
K
Y
FDS
C
---------
N
--
G
D-
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
---
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
----
P
T
----
E
E
Q
W
------
P
S
M
T
K
L
P
D
Y
K
-----
P
Y
P
M
Y
--
P
A
T
-
T
S
LV
N
------
V
V
P
K
-
L
--------------
N
A
T
G
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
61.22
36%
-44
- C3 -
-
2WPA
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
61.12
36%
-34
- C3 -
-
2C5X
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
61.16
36%
-32
- C3 -
-
3QRU
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
61.15
36%
-33
- C3 -
-
3PXZ
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
61.12
35%
-32
- C3 -
-
4KRC
1
PHO85_YEAST
A:
[7-298]
---
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
K
T
T
G
V
Y
V
A
L
K
-
E
V
K
L
D
S
-
E
-
E
G
T
-
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
H
------
T
------
E
N
K
---
L
T
L
V
F
E
--------
F
M
D
-------
N
D
L
K
--
K
Y
---
M
DSRTP----
R
--
G
--
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
K
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
---
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
-
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
----
P
N
----
E
S
L
W
------
P
S
V
T
K
L
P
K
Y
N
-----
P
N
I
Q
Q
RP
P
R
D
-
L
R
--
Q
VLQPHT
K
E
P
--
L
--------------
D
G
N
L
M
D
----
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
61.10
36%
-42
- C3 -
-
2WPA
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
61.09
36%
-35
- C3 -
-
2X1N
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
61.07
36%
-38
- C3 -
-
2C4G
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
61.02
36%
-40
- C3 -
-
2WEV
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
60.90
36%
-36
- C3 -
-
2C5O
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
60.89
36%
-41
- C3 -
-
1FVV
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
60.88
36%
-38
- C3 -
-
2C5V
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
60.86
36%
-42
- C3 -
-
2BKZ
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
60.84
36%
-43
- C3 -
-
2I40
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
60.83
36%
-31
- C3 -
-
2EXM
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
60.78
36%
-37
- C3 -
-
3PY1
4
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
60.76
36%
-38
- C3 -
-
2WXV
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
60.74
36%
-40
- C3 -
-
3F5X
2
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
60.69
36%
-45
- C3 -
-
2I40
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
60.62
36%
-36
- C3 -
-
2WEV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
60.62
36%
-40
- C3 -
-
2BKZ
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
60.60
36%
-32
- C3 -
-
3PXF
7
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
60.47
36%
-38
- C3 -
-
1PXI
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
60.48
36%
-38
- C3 -
-
3EJ1
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
60.50
36%
-40
- C3 -
-
2BPM
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
60.48
36%
-37
- C3 -
-
4GCJ
5
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
60.47
36%
-28
- C3 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
60.45
36%
-38
- C3 -
-
4FX3
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.43
37%
-30
- C3 -
-
6GU2
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
------
D
S
R
---
L
Y
L
I
F
E
--------
F
L
S
M
---
D
L
K
K
Y
L
D
--
S
I
---
P
---------
P
--
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
----
P
N
N
E
-------------------
V
W
P
E
V
E
S
--
L
Q
D
-
Y
K
--
N
------
T
F
P
K
-
W
KPGSLASHVKNLDE
N
G
L
--
D
----
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
60.35
36%
-33
- C3 -
-
1YKR
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
60.30
36%
-33
- C3 -
-
3R83
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
60.29
36%
-40
- C3 -
-
3EOC
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
60.23
36%
-41
- C3 -
-
1E1V
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
60.15
36%
-32
- C3 -
-
4KD1
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
60.15
36%
-35
- C3 -
-
3R8V
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
60.13
36%
-42
- C3 -
-
2C5V
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
60.12
36%
-24
- C3 -
-
4AU8
2
CDK5_HUMAN
A:
[8-291]
---
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R-----------
V
-
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
---------------
K
---
L
T
L
V
F
E
--------
F
C
D
Q
-------
D
L
K
--
K
Y
FDS
C
---------
N
--
G
D-
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
---------
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
----
P
T
----
E
E
Q
W
------
P
S
M
T
K
L
P
D
Y
K
-----
P
Y
P
M
Y
--
P
A
T
-
T
S
LV
N
------
V
V
P
K
-
L
--------------
N
A
T
G
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
60.10
36%
-40
- C3 -
-
2WIH
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
60.07
36%
-39
- C3 -
-
2WIH
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
60.06
36%
-37
- C3 -
-
1FIN
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
60.02
36%
-40
- C3 -
-
2C4G
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
60.00
36%
-38
- C3 -
-
4FKL
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
60.01
36%
-32
- C3 -
-
2X1N
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
60.00
36%
-37
- C3 -
-
2BPM
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
59.99
36%
-39
- C3 -
-
2C6I
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
59.95
36%
-30
- C3 -
-
3NS9
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
59.95
36%
-33
- C3 -
-
5ANE
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
59.94
36%
-43
- C3 -
-
3EOC
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
59.88
36%
-55
- C3 -
-
3QHR
6
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
59.87
36%
-34
- C3 -
-
4EZ7
7
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
59.84
36%
-35
- C3 -
-
2R3R
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
59.80
36%
-38
- C3 -
-
2VTM
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
59.82
36%
-19
- C3 -
-
4AU8
2
CDK5_HUMAN
B:
[8-291]
---
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
------
E
G
V
-
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
------
S
-------
K
K
---
L
T
L
V
F
E
--------
F
C
D
Q
-------
D
L
K
--
K
Y
FDS
C
---------
N
--
G
D-
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
-------------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
----
P
T
----
E
E
Q
W
------
P
S
M
T
K
L
P
D
Y
K
-----
P
Y
P
M
Y
--
P
A
T
-
T
S
LV
N
------
V
V
P
K
-
L
--------------
N
A
T
G
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
59.81
36%
-32
- C3 -
-
3RPO
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
59.80
36%
-31
- C3 -
-
4EK4
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
59.79
36%
-37
- C3 -
-
3EJ1
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
59.77
36%
-35
- C3 -
-
3QZH
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
59.72
36%
-31
- C3 -
-
3S00
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
59.65
36%
-38
- C3 -
-
1PXO
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
59.62
36%
-41
- C3 -
-
2C5X
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
59.65
36%
-32
- C3 -
-
3UNJ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
59.62
36%
-37
- C3 -
-
4FKU
3
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
59.60
36%
-40
- C3 -
-
2C6O
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
59.59
36%
-32
- C3 -
-
3RM7
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
59.58
36%
-35
- C3 -
-
6Q4H
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
59.54
36%
-51
- C3 -
-
5MHQ
1
?
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
-
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
59.51
36%
-43
- C3 -
-
5IEY
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
59.52
36%
-32
- C3 -
-
2CLX
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
59.51
36%
-42
- C3 -
-
6Q4J
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
59.50
36%
-39
- C3 -
-
1Y8Y
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
59.49
36%
-25
- C3 -
-
1UNG
1
CDK5_HUMAN
A:
[1-287]
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
-
D
-
E
G
V
-
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
K
K
---
L
T
L
V
F
E
--------
F
C
D
Q
-------
D
L
K
--
K
Y
FDS
C
---------
N
--
G
D-
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
---
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
----
P
T
----
E
E
Q
W
------
P
S
M
T
K
L
P
D
Y
K
-----
P
Y
P
M
Y
--
P
A
T
-
T
S
LV
N
------
V
V
P
K
-
L
--------------
N
A
T
G
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
59.48
36%
-31
- C3 -
-
3QX2
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
59.39
36%
-48
- C3 -
-
1H1R
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
59.37
36%
-53
- C3 -
-
4I3Z
3
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
59.39
36%
-32
- C3 -
-
1E1X
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
59.43
36%
-39
- C3 -
-
4LYN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
59.32
36%
-54
- C3 -
-
5LMK
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
59.42
36%
-40
- C3 -
-
1PXL
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
59.41
36%
-34
- C3 -
-
3LFQ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
59.35
36%
-33
- C3 -
-
1PXJ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
59.39
36%
-40
- C3 -
-
1FIN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
59.37
36%
-34
- C3 -
-
3RAI
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
59.31
36%
-31
- C3 -
-
1PXP
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
59.35
36%
-32
- C3 -
-
3R8U
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
59.34
36%
-37
- C3 -
-
3QTZ
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
59.33
36%
-44
- C3 -
-
2WIP
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
59.32
36%
-33
- C3 -
-
3QQL
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
59.31
36%
-32
- C3 -
-
3R1Y
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
59.28
36%
-30
- C3 -
-
2XNB
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
----
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
59.27
36%
-31
- C3 -
-
1HCK
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
59.22
36%
-37
- C3 -
-
2C6M
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
59.26
36%
-35
- C3 -
-
1PF8
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
59.22
36%
-38
- C3 -
-
4EZ3
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
59.21
36%
-32
- C3 -
-
3QTQ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
59.16
36%
-37
- C3 -
-
2VTL
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
59.19
36%
-40
- C3 -
-
5ANI
1
CDK2_HUMAN
A:
[2-286]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
59.10
36%
-55
- C3 -
-
1H1Q
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
59.17
36%
-31
- C3 -
-
2XMY
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-----
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
59.14
36%
-35
- C3 -
-
3TI1
8
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
59.16
36%
-46
- C3 -
-
5IEV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
59.07
36%
-54
- C3 -
-
1OI9
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
59.15
36%
-51
- C3 -
-
4I3Z
4
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
59.14
36%
-32
- C3 -
-
3R73
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
59.12
36%
-37
- C3 -
-
3IGG
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
59.10
36%
-34
- C3 -
-
1B38
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
59.07
36%
-29
- C3 -
-
3R7Y
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
59.06
35%
-34
- C3 -
-
2IW8
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
H
V
D
Q
---
D
L
K
K
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
59.01
36%
-29
- C3 -
-
3QQG
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
59.02
36%
-33
- C3 -
-
2A0C
1
CDK2_HUMAN
X:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
59.01
36%
-29
- C3 -
-
3R1S
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
59.01
36%
-32
- C3 -
-
3R8P
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
58.89
36%
-51
- C3 -
-
2UZE
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
59.00
36%
-32
- C3 -
-
3QQF
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
58.97
36%
-37
- C3 -
-
1VYW
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
58.95
36%
-31
- C3 -
-
3R6X
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
58.95
35%
-30
- C3 -
-
2PMI
2
PHO85_YEAST
A:
[19-298]
---------------
A
T
V
Y
K
G
L
N
K
T
T
G
V
Y
V
A
L
K
-
E
V
K
L
D
S
-
E
-
E
G
T
-
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
H
E
N
I
V
R
L
Y
D
V
I
H
------
T
------
E
N
K
---
L
T
L
V
F
E
--------
F
M
D
-------
N
D
L
K
--
K
Y
---
M
DSRTVGNTP
R
--
G
--
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
K
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
---
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
-
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
----
P
N
----
E
S
L
W
------
P
S
V
T
K
L
P
K
Y
N
-----
P
N
I
Q
Q
RP
P
R
D
-
L
R
--
Q
VLQPHT
K
E
P
--
L
--------------
D
G
N
L
M
D
----
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
58.94
35%
-21
- C3 -
-
4EOI
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
H
Q
---
D
L
K
D
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
58.93
36%
-33
- C3 -
-
2B54
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
58.92
36%
-31
- C3 -
-
3QZI
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
58.91
36%
-37
- C3 -
-
1B39
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
58.90
36%
-47
- C3 -
-
2UZL
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
58.89
36%
-41
- C3 -
-
2WIP
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
--
D
A
---
S
---------
A
LT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
58.84
36%
-37
- C3 -
-
2C69
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
58.78
36%
-59
- C3 -
-
6GVA
3
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
----
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
58.86
36%
-60
- C3 -
-
2UZB
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
58.85
36%
-41
- C3 -
-
2VTP
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
58.84
36%
-34
- C3 -
-
3QQK
6
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
58.74
36%
-55
- C3 -
-
1H1P
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
58.67
35%
-57
- C3 -
-
1V0P
1
CDC2H_PLAFK
B:
[2-284]
-
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
--------------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------------
L
V
L
V
F
E
--------
H
L
D
Q
---
D
-
L
K
K
L
L
--
D
V
---
C
---------
E
--
G
G-
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
--------------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
----
P
N
SKNW
P
N
V
T
------
E
L
P
K
Y
D
P
N
F
T
-------
V
Y
E
--
P
L
P
-
W
E
--
S
------
F
L
K
G
-
L
--------------
D
E
S
G
I
D
----
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
58.79
36%
-30
- C3 -
-
3R28
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
58.78
36%
-54
- C3 -
-
5CYI
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
58.77
36%
-35
- C3 -
-
2B53
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
58.75
36%
-51
- C3 -
-
5NEV
1
?
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
58.52
36%
-51
- C3 -
-
1P5E
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
58.74
36%
-40
- C3 -
-
1PXM
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
58.68
36%
-36
- C3 -
-
2C6K
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
58.72
36%
-52
- C3 -
-
5NEV
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
58.68
36%
-36
- C3 -
-
4EK5
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
58.68
36%
-43
- C3 -
-
4FKQ
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
58.67
36%
-45
- C3 -
-
1H1R
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
58.63
36%
-38
- C3 -
-
3ULI
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
58.63
36%
-38
- C3 -
-
3RNI
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
58.56
36%
-41
- C3 -
-
1JSV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
58.61
36%
-30
- C3 -
-
3TIZ
9
CDK2_HUMAN
A:
[2-286]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
58.60
36%
-30
- C3 -
-
3TIY
12
CDK2_HUMAN
A:
[2-286]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
58.49
36%
-57
- C3 -
-
1H1P
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
58.58
36%
-32
- C3 -
-
2C68
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
58.56
36%
-37
- C3 -
-
2R3G
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
58.55
36%
-54
- C3 -
-
1E9H
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
58.51
36%
-40
- C3 -
-
2V0D
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
58.46
36%
-13
- C3 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-284]
--
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
K
I
R
L
-----------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
K
R
---
L
V
L
V
F
E
--------
H
L
D
Q
---
D
-
L
K
K
L
L
--
D
V
---
C
---------
E
--
G
G-
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
----
P
N
SKNW
P
N
V
T
------
E
L
P
K
Y
D
P
N
F
T
-------
V
Y
E
--
P
L
P
-
W
E
--
S
------
F
L
K
G
-
L
--------------
D
E
S
G
I
D
----
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
58.54
36%
-17
- C3 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-284]
--
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
K
I
R
L
-------------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
K
R
---
L
V
L
V
F
E
--------
H
L
D
Q
---
D
-
L
K
K
L
L
--
D
V
---
C
---------
E
--
G
G-
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
----
P
N
SKNW
P
N
V
T
------
E
L
P
K
Y
D
P
N
F
T
-------
V
Y
E
--
P
L
P
-
W
E
--
S
------
F
L
K
G
-
L
--------------
D
E
S
G
I
D
----
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
58.53
36%
-30
- C3 -
-
3ROY
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
58.52
36%
-32
- C3 -
-
3RPV
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
58.51
36%
-35
- C3 -
-
3PJ8
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
58.49
36%
-33
- C3 -
-
3R8L
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
58.48
36%
-35
- C3 -
-
3QXP
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
58.48
36%
-32
- C3 -
-
3R9H
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
58.47
36%
-44
- C3 -
-
3EID
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
58.46
36%
-35
- C3 -
-
3S0O
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
58.45
36%
-57
- C3 -
-
3DDP
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
58.41
36%
-42
- C3 -
-
2UZO
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
58.40
36%
-31
- C3 -
-
2R3H
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
58.44
36%
-45
- C3 -
-
1DI8
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
58.32
36%
-50
- C3 -
-
2UZE
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
58.43
36%
-52
- C3 -
-
2UZL
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
58.34
36%
-54
- C3 -
-
1H1Q
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
58.32
36%
-53
- C3 -
-
2CCI
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
58.41
36%
-30
- C3 -
-
3PXY
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
58.40
36%
-35
- C3 -
-
3PY0
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
58.38
36%
-31
- C3 -
-
3R1Q
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
58.27
36%
-53
- C3 -
-
1QMZ
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
58.27
36%
-52
- C3 -
-
1QMZ
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
58.37
36%
-32
- C3 -
-
2R3F
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
58.36
36%
-31
- C3 -
-
3RK9
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
58.27
36%
-57
- C3 -
-
1OIU
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
58.35
36%
-54
- C3 -
-
3DOG
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
58.26
36%
-57
- C3 -
-
1OGU
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
58.34
36%
-44
- C3 -
-
6GUK
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
58.33
36%
-52
- C3 -
-
3QHW
3
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
58.24
36%
-49
- C3 -
-
1OIY
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
58.26
36%
-38
- C3 -
-
1H0W
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
58.22
36%
-53
- C3 -
-
4BCO
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
58.31
36%
-33
- C3 -
-
5JQ5
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
58.23
36%
-55
- C3 -
-
4BCM
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
58.29
36%
-42
- C3 -
-
5IEX
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
58.30
36%
-42
- C3 -
-
2VTA
3
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
58.20
36%
-53
- C3 -
-
4BCP
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
58.29
36%
-32
- C3 -
-
3QTX
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
58.18
36%
-56
- C3 -
-
3BHU
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
58.27
36%
-34
- C3 -
-
2A4L
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
58.26
36%
-28
- C3 -
-
6Q4A
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
58.25
36%
-35
- C3 -
-
3QWJ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
58.22
36%
-44
- C3 -
-
2VTS
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
58.25
36%
-30
- C3 -
-
3R7V
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
58.24
36%
-27
- C3 -
-
3R71
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
58.23
36%
-38
- C3 -
-
6Q4G
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
58.10
35%
-9
- C3 -
-
1V0P
1
CDC2H_PLAFK
A:
[1-284]
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
A
L
K
K
I
R
L
E
K
E
-
D
-
E
G
I
-
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
------
K
K
R
---
L
V
L
V
F
E
--------
H
L
D
Q
---
D
-
L
K
K
L
L
--
D
V
---
C
---------
E
--
G
G-
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
----------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
----
P
N
SKNW
P
N
V
T
------
E
L
P
K
Y
D
P
N
F
T
-------
V
Y
E
--
P
L
P
-
W
E
--
S
------
F
L
K
G
-
L
--------------
D
E
S
G
I
D
----
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
58.22
36%
-36
- C3 -
-
3R8Z
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----------
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
58.21
36%
-30
- C3 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-294]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
58.14
35%
-41
- C3 -
-
4EOM
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
S
M
---
D
L
K
K
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
58.20
36%
-30
- C3 -
-
3RK5
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
58.12
36%
-35
- C3 -
-
6Q4F
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
58.18
36%
-33
- C3 -
-
3R9D
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
58.18
36%
-31
- C3 -
-
6Q4B
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
58.17
36%
-55
- C3 -
-
4EOO
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
58.14
36%
-34
- C3 -
-
3QQJ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
58.10
36%
-44
- C3 -
-
2VTO
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
58.13
36%
-51
- C3 -
-
1GY3
2
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
58.03
36%
-57
- C3 -
-
3MY5
3
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
58.08
36%
-31
- C3 -
-
2C5Y
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
58.08
36%
-41
- C3 -
-
2R64
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
58.02
36%
-57
- C3 -
-
3TNW
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
58.11
36%
-35
- C3 -
-
3LE6
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
--------
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
58.00
36%
-52
- C3 -
-
3DDQ
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
58.10
36%
-35
- C3 -
-
3LFS
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
57.99
36%
-51
- C3 -
-
3DDP
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
57.97
36%
-49
- C3 -
-
1GY3
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
58.08
36%
-35
- C3 -
-
2VTR
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
57.97
36%
-49
- C3 -
-
4EOS
1
CDK2_HUMAN
C:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
58.04
36%
-52
- C3 -
-
4CFX
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
58.03
36%
-32
- C3 -
-
3QZG
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
57.95
36%
-50
- C3 -
-
4BCQ
1
CDK2_HUMAN
C:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
58.02
36%
-53
- C3 -
-
5CYI
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
58.01
36%
-43
- C3 -
-
1PXK
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
57.99
36%
-33
- C3 -
-
3QRT
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
58.00
36%
-42
- C3 -
-
6Q48
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
57.99
36%
-29
- C3 -
-
3R7E
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
57.99
36%
-37
- C3 -
-
6Q4C
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
57.98
36%
-37
- C3 -
-
1PXN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
57.88
36%
-50
- C3 -
-
4BCK
2
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
57.97
36%
-28
- C3 -
-
3QXO
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
57.84
36%
-50
- C3 -
-
1JST
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
57.96
36%
-37
- C3 -
-
3QTW
6
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
57.84
36%
-54
- C3 -
-
2UZB
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
57.95
36%
-35
- C3 -
-
6Q4K
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
57.94
36%
-49
- C3 -
-
2G9X
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
57.92
36%
-54
- C3 -
-
1OIY
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
57.91
36%
-54
- C3 -
-
1E9H
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
57.90
36%
-56
- C3 -
-
3BHT
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
57.89
36%
-39
- C3 -
-
1CKP
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
57.88
36%
-52
- C3 -
-
4BCN
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
57.76
36%
-48
- C3 -
-
2UZD
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
57.87
36%
-34
- C3 -
-
1H0V
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
57.86
36%
-54
- C3 -
-
4CFM
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
57.75
36%
-53
- C3 -
-
3QHR
2
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
57.73
36%
-53
- C3 -
-
2C6T
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
57.84
36%
-33
- C3 -
-
3QQH
4
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
57.83
36%
-43
- C3 -
-
3WBL
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
57.82
36%
-51
- C3 -
-
4CFV
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
57.71
36%
-52
- C3 -
-
4BCK
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
57.80
36%
-42
- C3 -
-
4D1X
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
57.73
35%
-33
- C3 -
-
4EOK
1
CDK2_HUMAN
C:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
S
M
---
D
L
K
D
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
57.79
36%
-50
- C3 -
-
1H1S
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
57.78
36%
-52
- C3 -
-
4EOP
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
57.75
36%
-31
- C3 -
-
3LFN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
----------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
57.69
36%
-57
- C3 -
-
6GUC
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
57.65
36%
-49
- C3 -
-
4II5
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
57.76
36%
-34
- C3 -
-
3QL8
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
57.75
36%
-25
- C3 -
-
3UNK
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
57.71
36%
-45
- C3 -
-
2VTH
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
57.74
36%
-51
- C3 -
-
3QHW
2
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
57.69
36%
-39
- C3 -
-
2C6L
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
57.69
36%
-32
- C3 -
-
4FKG
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
57.73
36%
-43
- C3 -
-
3RPR
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
57.71
36%
-44
- C3 -
-
4FKT
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
57.65
36%
-56
- C3 -
-
4BCM
1
CDK2_HUMAN
C:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
57.72
36%
-45
- C3 -
-
5A14
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
----
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
57.71
36%
-35
- C3 -
-
3RKB
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
57.60
36%
-52
- C3 -
-
1P5E
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
57.69
36%
-44
- C3 -
-
4FKP
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
57.70
36%
-28
- C3 -
-
3QTU
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
57.69
36%
-33
- C3 -
-
3PXQ
4
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
57.67
36%
-31
* C3 *
-
4EOI
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
H
Q
---
D
L
K
D
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
57.65
36%
-35
- C3 -
-
6Q4I
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
L
---
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
57.63
36%
-44
- C3 -
-
3QTS
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
57.63
36%
-32
- C3 -
-
3QZF
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
57.62
36%
-53
- C3 -
-
3BHV
2
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
57.61
36%
-53
- C3 -
-
4EOO
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
57.60
36%
-33
- C3 -
-
1WCC
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
57.58
36%
-40
- C3 -
-
2VTI
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
57.57
36%
-52
- C3 -
-
4CFN
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
57.47
36%
-50
- C3 -
-
3TNW
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
57.54
36%
-57
- C3 -
-
2CCI
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
57.53
36%
-35
- C3 -
-
2W1H
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
57.52
36%
-56
- C3 -
-
4EOQ
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
57.47
36%
-40
- C3 -
-
2UZN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
57.49
36%
-34
- C3 -
-
3QX4
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
57.48
36%
-53
- C3 -
-
4CFU
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
57.46
36%
-36
- C3 -
-
4FKI
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
57.47
36%
-31
- C3 -
-
3QWK
5
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
57.39
36%
-54
- C3 -
-
4CFW
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
57.47
36%
-40
- C3 -
-
3R9N
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
57.46
36%
-42
- C3 -
-
3QTR
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
57.34
36%
-48
- C3 -
-
4II5
3
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
57.44
36%
-48
- C3 -
-
1OI9
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
57.31
36%
-41
- C3 -
-
2C6T
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
57.42
36%
-56
- C3 -
-
2UZD
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
57.39
36%
-43
- C3 -
-
6Q4E
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
57.38
36%
-29
- C3 -
-
3RJC
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
57.36
36%
-36
- C3 -
-
3FZ1
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
57.35
36%
-42
- C3 -
-
4FKO
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
57.27
36%
-51
- C3 -
-
4BCQ
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
57.27
35%
-29
- C3 -
-
4EON
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
S
M
---
D
L
K
K
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
57.32
36%
-53
- C3 -
-
4CFN
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
57.31
36%
-48
- C3 -
-
6GUE
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV---------
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
------
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
57.30
36%
-38
- C3 -
-
1H08
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
57.29
36%
-50
- C3 -
-
4EOS
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
57.28
36%
-44
- C3 -
-
1KE6
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
57.27
36%
-43
- C3 -
-
1KE9
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
57.26
36%
-50
- C3 -
-
1PKD
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
57.25
36%
-49
- C3 -
-
5L2W
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
57.24
36%
-48
- C3 -
-
2CCH
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
57.23
36%
-54
- C3 -
-
4BCN
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
57.14
36%
-47
- C3 -
-
6GUF
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
57.15
35%
-30
- C3 -
-
4EOL
1
CDK2_HUMAN
C:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
S
M
---
D
L
K
D
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
57.12
36%
-56
- C3 -
-
4CFX
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
57.19
36%
-53
- C3 -
-
4EOR
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
57.18
36%
-51
- C3 -
-
2G9X
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PD--------------------------------------------------------
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
57.14
36%
-42
- C3 -
-
4EK8
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
57.15
36%
-35
- C3 -
-
1H07
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
----
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
57.14
36%
-46
- C3 -
-
3R7I
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
57.13
36%
-51
- C3 -
-
2VV9
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
57.12
35%
-27
- C3 -
-
4EON
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
S
M
---
D
L
K
K
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
57.10
36%
-51
- C3 -
-
6GUC
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
57.09
36%
-55
- C3 -
-
6GUF
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
57.08
36%
-53
- C3 -
-
1H1S
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
57.07
36%
-41
- C3 -
-
3RAH
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
57.05
36%
-37
- C3 -
-
2BHH
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
56.96
36%
-59
- C3 -
-
6GUB
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
57.01
36%
-39
- C3 -
-
5AND
1
CDK2_HUMAN
A:
[2-286]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
56.99
36%
-44
- C3 -
-
4FKW
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
56.99
36%
-40
- C3 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
56.97
35%
-34
- C3 -
-
4EOK
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
S
M
---
D
L
K
D
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
56.96
36%
-47
- C3 -
-
4EOP
1
CDK2_HUMAN
C:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
56.95
36%
-42
- C3 -
-
1KE7
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
56.82
35%
-30
- C3 -
-
4EOL
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
S
M
---
D
L
K
D
F
M
D
--
A
S
----L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
56.94
36%
-53
- C3 -
-
6GUE
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
N
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
56.93
36%
-40
- C3 -
-
3IG7
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
56.89
36%
-37
- C3 -
-
3SW4
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
56.82
36%
-42
- C3 -
-
2W06
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
56.88
36%
-29
- C3 -
-
3RK7
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
56.85
36%
-36
- C3 -
-
5FP6
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
56.72
36%
-55
- C3 -
-
1JST
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
56.82
36%
-38
- C3 -
-
4FKJ
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
56.80
36%
-44
- C3 -
-
6Q3B
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
56.78
36%
-45
- C3 -
-
2R3P
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
56.75
36%
-42
- C3 -
-
2R3I
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
56.73
36%
-34
- C3 -
-
6Q4D
6
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
56.72
35%
-38
- C3 -
-
4EOJ
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
S
M
---
D
L
K
D
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
56.66
36%
-45
- C3 -
-
2R3O
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
56.63
36%
-63
- C3 -
-
5LMK
1
?
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------------------------------------
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
56.61
36%
-41
- C3 -
-
2VU3
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
----
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
56.60
36%
-52
- C3 -
-
6GUB
1
?
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
--------------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
56.56
36%
-50
- C3 -
-
2CCH
3
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
56.49
36%
-41
- C3 -
-
1AQ1
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
56.54
36%
-46
- C3 -
-
5K4J
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
56.49
36%
-43
- C3 -
-
1VYZ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
56.52
36%
-60
- C3 -
-
1OIU
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------------------------------------
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
56.50
36%
-28
- C3 -
-
5OSM
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
C
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
56.49
36%
-39
- C3 -
-
4FKS
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
56.48
36%
-44
- C3 -
-
3R7U
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
56.47
36%
-38
- C3 -
-
4EK6
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
56.46
36%
-51
- C3 -
-
4CFW
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
56.43
36%
-34
- C3 -
-
3SQQ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
------
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
56.35
36%
-58
- C3 -
-
4EOQ
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P--------------------------------------------------------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
56.40
36%
-39
- C3 -
-
1H00
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
56.39
36%
-37
- C3 -
-
3S2P
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
56.29
36%
-33
- C3 -
-
2IW6
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
H
Q
DLK
T
F
M
D
--
A
--
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
56.35
36%
-41
- C3 -
-
1KE5
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
56.34
36%
-41
- C3 -
-
2J9M
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
56.32
36%
-42
- C3 -
-
1URW
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
56.31
36%
-51
- C3 -
-
1PKD
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
56.29
36%
-39
- C3 -
-
2VTJ
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
56.28
36%
-43
- C3 -
-
4FKR
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
56.25
36%
-61
- C3 -
-
3MY5
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------------------------------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
56.20
36%
-42
- C3 -
-
3RZB
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
56.13
36%
-29
- C3 -
-
5OO3
1
CDK2_HUMAN
A:
[7-291]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
C
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
56.15
36%
-43
- C3 -
-
1KE8
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
56.13
36%
-43
- C3 -
-
1FVT
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
56.12
36%
-45
- C3 -
-
3RPY
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
56.10
36%
-46
- C3 -
-
3RAK
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
56.06
36%
-59
- C3 -
-
3DDQ
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------------------------------------
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
56.05
36%
-52
- C3 -
-
4BCO
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P-----------------------------------------------------------
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
56.01
36%
-45
- C3 -
-
1W8C
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
56.00
36%
-40
- C3 -
-
2BTS
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
55.99
36%
-50
- C3 -
-
2BTR
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
55.98
36%
-48
- C3 -
-
5ANK
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
-------------------
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
55.97
36%
-45
- C3 -
-
2W17
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
-
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
55.94
36%
-42
- C3 -
-
2VTQ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
55.87
36%
-43
- C3 -
-
3S1H
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
55.83
36%
-42
- C3 -
-
2R3Q
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
55.73
36%
-57
- C3 -
-
3DOG
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P-----------------------------------------------------------------------------
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
55.69
36%
-38
- C3 -
-
1W0X
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
55.68
36%
-46
- C3 -
-
1V1K
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
55.62
36%
-44
- C3 -
-
3RMF
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
55.60
35%
-40
- C3 -
-
1GII
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
HVHQDLKT
F
M
D
A
---
S
A
L
T
-----------------------
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
55.57
36%
-37
- C3 -
-
4FKV
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
55.47
36%
-43
- C3 -
-
2IW9
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
H
Q
DLK
T
F
M
D
--
A
--
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PD---------------------------------------------------------------------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
55.52
36%
-41
- C3 -
-
3R9O
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
55.47
36%
-39
- C3 -
-
1OIT
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
55.45
36%
-36
- C3 -
-
3R8M
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
55.35
35%
-42
- C3 -
-
4EOM
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
S
M
---
D
L
K
K
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P--------------------------------------------------------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
55.41
36%
-43
- C3 -
-
1Y91
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
55.35
36%
-38
- C3 -
-
2DUV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------------
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
55.32
36%
-44
- C3 -
-
2VTT
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
55.31
36%
-23
- C3 -
-
3O0G
1
CDK5_HUMAN
B:
[6-287]
-----
K
L
E
K
I
-----
G
T
V
F
K
A
------
E
I
V
A
L
K
R
V
R
-----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
K
K
---
L
T
L
V
F
E
--------
F
C
D
Q
-------
D
L
K
--
K
Y
FDS
C
---------
N
--
G
D-
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
---
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
----
P
T
----
E
E
Q
W
------
P
S
M
T
K
L
P
D
Y
K
-----
P
Y
P
M
Y
--
P
A
T
-
T
S
LV
N
------
V
V
P
K
-
L
--------------
N
A
T
G
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
55.26
36%
-39
- C3 -
-
4BGH
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
55.21
36%
-35
- C3 -
-
5OO1
1
CDK2_HUMAN
A:
[9-291]
---
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
C
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
55.15
36%
-39
- C3 -
-
4ACM
3
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
--------
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
55.14
36%
-41
- C3 -
-
2W05
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
55.13
36%
-35
- C3 -
-
2B55
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
55.12
36%
-43
- C3 -
-
1G5S
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
55.09
36%
-35
- C3 -
-
6GUH
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
--------
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
55.01
36%
-33
- C3 -
-
2IW6
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
H
Q
DLK
T
F
M
D
--
A
--
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
55.07
36%
-49
- C3 -
-
1FQ1
1
CDK2_HUMAN
B:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
55.06
36%
-54
- C3 -
-
4CFM
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PD-----------------------------------------------------------------------------
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
55.03
36%
-55
- C3 -
-
4EOR
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PD--------------------------------------------------------
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
55.01
36%
-39
- C3 -
-
4BZD
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
54.96
36%
-27
- C3 -
-
3RM6
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
54.92
36%
-51
- C3 -
-
3BHU
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P----------------------------------------------------------
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
54.87
36%
-34
- C3 -
-
2B52
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
------------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
54.86
36%
-54
- C3 -
-
3BHT
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P----------------------------------------------------------
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
54.85
36%
-37
- C3 -
-
2VTN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
54.80
36%
-34
- C3 -
-
1DM2
5
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
54.79
36%
-45
- C3 -
-
3RAL
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
54.78
36%
-30
- C3 -
-
2IW9
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
H
Q
DLK
T
F
M
D
--
A
--
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
54.74
36%
-49
- C3 -
-
1OGU
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P----------------------------------------------------------
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
54.68
36%
-44
- C3 -
-
6INL
1
?
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
54.59
36%
-43
- C3 -
-
2FVD
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------------
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
--
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
54.58
35%
-45
- C3 -
-
4EOJ
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
S
M
---
D
L
K
D
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
---------------------------------------------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
54.35
36%
-56
- C3 -
-
4NJ3
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
54.33
36%
-52
- C3 -
-
2R3K
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
54.23
36%
-39
- C3 -
-
3EZV
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
54.21
36%
-43
- C3 -
-
3SW7
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
54.13
36%
-42
- C3 -
-
1GIH
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
54.17
36%
-47
- C3 -
-
5FP5
3
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------------
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
54.13
36%
-37
- C3 -
-
1R78
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
54.06
36%
-47
- C3 -
-
2R3M
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
54.02
35%
-34
- C3 -
-
2IW8
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
H
V
D
Q
---
D
L
K
K
F
M
D
--
A
S
---
A
L--------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------------------------------------
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
54.00
36%
-48
- C3 -
-
2R3J
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
53.86
36%
-51
- C3 -
-
3BHV
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P----------------------------------------------------------
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
53.83
36%
-39
- C3 -
-
5ANG
1
CDK2_HUMAN
A:
[2-286]
-
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------------
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
53.82
34%
-33
- C3 -
-
3BLR
1
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
---------S--
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
--------PNR
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY
E
L
Y
E
K
L
E
L
V
K
------------
V
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
53.69
36%
-42
- C3 -
-
3EZR
2
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
-------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
53.63
36%
-51
- C3 -
-
4CFU
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P----------------------------------------------------------
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
53.58
36%
-57
- C3 -
-
4CFV
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P-----------------------------------------------------------------------------
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
53.40
34%
-23
- C3 -
-
4BCI
1
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
---------GS-
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
--------PNR
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY
E
L
Y
E
K
L
E
L
V
K
G
-----
Q
K
R
K
--
V
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
53.10
36%
-25
- C3 -
-
1UNG
1
CDK5_HUMAN
B:
[2-287]
-
Q
K
Y
E
K
L
E
K
-------
T
V
F
K
A
-------
I
V
A
L
K
R
V
R
L
D
------
G
V
-
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------
D
K
K
---
L
T
L
V
F
E
--------
F
C
D
Q
-------
D
L
K
--
K
Y
FDS
C
---------
N
--
G
D-
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
---
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
----
P
T
----
E
E
Q
W
------
P
S
M
T
K
L
P
D
Y
K
-----
P
Y
P
M
Y
--
P
A
T
-
T
S
LV
N
------
V
V
P
K
-
L
--------------
N
A
T
G
R
D
----
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
52.99
36%
-51
- C3 -
-
4BCP
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
-
T
-
E
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P----------------------------------------------------------
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
52.93
36%
-44
- C3 -
-
1P2A
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
52.77
34%
-19
- C3 -
-
3LQ5
1
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
--
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
---------KGS
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
--------PNR
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY
E
L
Y
E
K
L
E
L
V
K
G
-----
Q
K
R
K
--
V
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
52.63
36%
-41
- C3 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
---------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
--------
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
52.54
36%
-37
- C3 -
-
5D1J
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K-----------------
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
52.46
34%
-17
- C3 -
-
4BCF
1
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
---------KAS
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
---------PNR
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY
E
L
Y
E
K
L
E
L
V
K
G
-----
Q
K
R
K
--
V
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
52.42
34%
-12
- C3 -
-
3MY1
3
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
------
K
--KGS
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
----
S
Q
PNR
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY
E
L
Y
E
K
L
E
L
V
K
G
-----
Q
K
R
K
--
V
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
52.35
34%
-23
- C3 -
-
4BCH
2
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
------
K
A
-GS-
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
---------PNR
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY
E
L
Y
E
K
L
E
L
V
K
G
-----
Q
K
R
K
--
V
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
52.25
34%
-24
- C3 -
-
3TN8
2
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
---------GS-
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
--------
Q
PNR
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY
E
L
Y
E
K
L
E
L
V
K
G
-----
Q
K
R
K
--
V
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
52.23
34%
-13
- C3 -
-
4BCG
2
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
---------KGS
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
----
S
Q
PNR
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY
E
L
Y
E
K
L
E
L
V
K
G
-----
Q
K
R
K
--
V
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
52.16
36%
-44
- C3 -
-
1OIQ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------------
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
52.03
35%
-41
- C3 -
-
1GIJ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
HVHQDLKT
F
M
D
A
---
S
A
L
T
-----------------------
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
51.62
36%
-50
- C3 -
-
2R3L
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
51.44
34%
-15
- C3 -
-
4BCJ
1
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
------
K
--KGS
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
--------PNR
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY
E
L
Y
E
K
L
E
L
V
K
G
-----
Q
K
R
K
--
V
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
51.39
36%
-43
- C3 -
-
1PYE
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
-----
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
50.80
34%
-19
- C3 -
-
3BLQ
1
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
---------S--
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
----------NR-
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY
E
L
Y
E
K
L
E
L
V
K
-------------
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
49.74
36%
-56
- C3 -
-
2R3N
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
49.21
34%
-22
- C3 -
-
3TNH
1
CDK9_HUMAN
A:
[20-319]
---
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
-
K
-
E
G
F
-
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
------
T
---------S--
I
Y
L
V
F
D
--------
F
C
E
H
---
D
L
A
G
L
L
S
--
N
V
---
L
---------
V
--
K
--
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
----------NR-
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
-
T
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
----
I
T
----
P
E
V
W
PNVDNY----------------------
V
K
D
-
R
L
--
K
------
A
Y
V
R
----------------
D
P
Y
A
L
D
----
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
46.29
36%
-32
- C3 -
-
4RJ3
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
-
I
R
L
D
T
E
----------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
42.18
36%
-75
- C3 -
-
1H01
3
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
-
I
R
--------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
42.04
36%
-74
- C3 -
-
1OIR
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
-
I
R
--------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
------
T
------
E
N
K
---
L
Y
L
V
F
E
--------
F
L
-
H
---
Q
D
L
K
K
F
M
DA
S
A
---
L
---------
T
--
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
PDEV
V
W
----
P
G
V
T
------
S
M
P
D
Y
K
P
S
F
-------------
P
K
W
-
A
R
--
Q
------
D
F
S
K
-
V
--------------
V
P
P
L
D
E
DGRS
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------