@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CHK2_HUMAN: (2021-11-22 )
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
Atome Classification :
(374 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......--------------210...--....220...-.....230.......240.......250--........260......-.270------.---.......280-..--.....-.-290-..-------.-.-.-.-------.300.......310..--..-..----.320.......330.......340.......350.-......360-.-......370-.-.---.-....380-..-.......390....---...400--.....-..410.......420.....-..--430----.....--...--------------.-440--..---.......450.......460.......470...-----....480--......----..--------.490.......500.......510.......520.......530.......540.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSRE
S
D
V
E
A
Q
Q
SHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
S
S
L
E
TV
S
T
Q
E
L
YSIPEDQEPEDQEPEEPTP
A
P
W
A
R
L
W
A
L
QDGFAN
L
E
C
VNDNYWFGRDKS
C
E
Y
C
FD
E
P
L
L
K
R
T
D
K
YRT
Y
S
K
K
H
F
R
I
F
R
E
VGPKN
S
Y
I
A
Y
I
EDHSGN
G
T
F
V
N
T
E
L
VGKGKRRPLNNN
S
E
I
A
L
S
LSR
N
K
V
F
V
F
F
D
L
T
VDDQ--------------SV
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K-TLGSGACG
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---SKRKFAIGSAREADPAL-N
V
E
-------
T
---
E
I
E
I
L
K
KL-N-H
P
--
C
I
I
K
I
-
K
-NFF-DA-------E-
D
-
Y
-
Y
-------
I
V
L
E
LMEG
G
E
L
F
D
K
V
V--GN-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
ENG
I
I
HRDLKPE
N
V
-
L
LSSQEE
D
C
-
L
-
I
K
I
TDFGHS-K-I---L-
G
E
T
S
L
---
M
R
-
T
L
CGTPTYL
A
P
E
V
L
---
V
S
VGTA--GYNR
A
-
V
D
C
W
S
L
G
V
I
L
F
I
CLSGYPPF-SE--H------
R
T
Q
V
S
--
L
K
D--------------Q-I----TS---GKYN
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
VVDPKARF-----
T
T
E
E
A
----LRHPWL----Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
SEENESTA
L
P
Q
V
LAQPSTSRKRPREGEAEGAETTKRPA
V
C
AAVL
591
HHSearch
97.26
100%
-132
- C1 -
-
3I6U
-
CHK2_HUMAN
A:
[89-501]
----------------------------------------------------------------------------------------
T
P
A
P
W
A
R
L
W
A
L
Q
D
G
F
A
N
L
E
C
V
N
D
N
Y
W
F
G
R
D
K
S
C
E
Y
C
F
D
E
P
L
L
K
R
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
R
E
V
G
P
K
N
S
Y
I
A
Y
I
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
G
K
G
K
R
R
P
L
N
N
N
S
E
I
A
L
S
L
S
R
N
K
V
F
V
F
F
D
L
T
V
D
D
Q
--------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
R
I
I
---
S
K
R
K
F
A
I
G
--------
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
---------------
P
T
Y
L
A
P
E
V
L
---
V
----
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
------------------------------------------
2
PsiBlast_PDB
97.03
99%
-132
- C1 -
-
3I6U
-
CHK2_HUMAN
A:
[89-501]
----------------------------------------------------------------------------------------
T
P
A
P
W
A
R
L
W
A
L
Q
D
G
F
A
N
L
E
C
V
N
D
N
Y
W
F
G
R
D
K
S
C
E
Y
C
F
D
E
P
L
L
K
R
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
R
E
V
G
P
K
N
S
Y
I
A
Y
I
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
G
K
G
K
R
R
P
L
N
N
N
S
E
I
A
L
S
L
S
R
N
K
V
F
V
F
F
D
L
T
V
D
D
Q
--------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
R
I
I
---
S
K
R
K
F
A
I
G
--------
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
---------------
P
T
Y
L
A
P
E
V
L
---
V
----
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
------------------------------------------
590
HHSearch
93.82
100%
-130
- C1 -
-
3I6U
-
CHK2_HUMAN
B:
[89-501]
----------------------------------------------------------------------------------------
T
P
A
P
W
A
R
L
W
A
L
Q
D
G
F
A
N
L
E
C
V
N
D
N
Y
W
F
G
R
D
K
S
C
E
Y
C
F
D
E
P
L
L
K
R
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
R
E
V
G
P
K
N
S
Y
I
A
Y
I
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
G
K
G
K
R
R
P
L
N
N
N
S
E
I
A
L
S
L
S
R
N
K
V
F
V
F
F
D
L
T
V
D
D
Q
--------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
R
I
I
---
S
K
R
K
F
A
I
G
--------
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
----------------------------
P
T
Y
L
A
P
E
V
L
---
V
---------
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
------------
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
------------------------------------------
1
PsiBlast_PDB
91.56
99%
-136
* C2 *
-
3I6W
-
CHK2_HUMAN
A:
[92-501]
-------------------------------------------------------------------------------------------
P
W
A
R
L
W
A
L
Q
D
G
F
A
N
L
E
C
V
N
D
N
Y
W
F
G
R
D
K
S
C
E
Y
C
F
D
E
P
L
L
K
R
T
D
K
Y
R
T
Y
S
K
K
H
F
R
I
F
R
E
V
G
P
K
N
S
Y
I
A
Y
I
E
D
H
S
G
N
G
T
F
V
N
T
E
L
V
G
K
G
K
R
R
P
L
N
N
N
S
E
I
A
L
S
L
S
R
N
K
V
F
V
F
F
D
L
T
V
D
D
Q
--------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
R
I
I
---
S
K
--------------
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
----------------------------
P
T
Y
L
A
P
E
V
L
---
V
----
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
------------------------------------------
20
PsiBlast_PDB
76.47
100%
-137
- C1 -
-
4A9R
2
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
25
Blastp_CBE
76.34
100%
-138
- C1 -
-
4BDG
2
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
8
PsiBlast_PDB
76.20
100%
-138
- C1 -
-
2YCQ
1
CHK2_HUMAN
A:
[3-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
15
PsiBlast_PDB
76.12
100%
-133
- C1 -
-
2WTI
3
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
--
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
7
PsiBlast_PDB
75.84
100%
-138
- C1 -
-
2YIT
1
CHK2_HUMAN
A:
[3-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
--------------
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
23
Blastp_CBE
75.77
100%
-130
- C1 -
-
4BDI
7
CHK2_HUMAN
A:
[8-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
-------------
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Q
P
----------------------------
4
PsiBlast_PDB
75.77
100%
-135
- C1 -
-
2W7X
3
CHK2_HUMAN
A:
[2-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
16
PsiBlast_PDB
75.76
100%
-138
- C1 -
-
2WTJ
5
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
--
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
26
Blastp_CBE
75.38
100%
-136
- C1 -
-
4BDF
3
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
33
Blastp_CBE
75.22
100%
-130
- C1 -
-
4A9T
4
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
35
Blastp_CBE
75.17
100%
-133
- C1 -
-
2YCF
1
CHK2_HUMAN
A:
[2-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
24
Blastp_CBE
75.02
100%
-143
- C1 -
-
4BDH
4
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
21
Blastp_CBE
74.94
100%
-135
- C1 -
-
4BDK
4
CHK2_HUMAN
A:
[9-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
-------------
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------
14
PsiBlast_PDB
74.94
100%
-135
- C1 -
-
2WTD
4
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
10
PsiBlast_PDB
74.92
100%
-130
- C1 -
-
2XK9
1
CHK2_HUMAN
A:
[2-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
34
Blastp_CBE
74.88
100%
-134
- C1 -
-
4A9S
1
CHK2_HUMAN
A:
[9-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
29
Blastp_CBE
74.86
100%
-137
- C1 -
-
4BDC
2
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
--
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
32
Blastp_CBE
74.79
100%
-135
- C1 -
-
4A9U
10
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
-----------
D
P
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
5
PsiBlast_PDB
74.74
100%
-137
- C1 -
-
2YIQ
1
CHK2_HUMAN
A:
[3-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
-----------------
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
6
PsiBlast_PDB
74.73
100%
-134
- C1 -
-
2YIR
1
CHK2_HUMAN
A:
[2-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
--------------
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
----------------------------------
31
Blastp_CBE
74.64
100%
-138
- C1 -
-
4BDA
8
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
--
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
19
PsiBlast_PDB
74.57
100%
-133
- C1 -
-
2XM9
1
CHK2_HUMAN
A:
[9-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
27
Blastp_CBE
74.55
100%
-143
- C1 -
-
4BDE
5
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
-------------
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
28
Blastp_CBE
74.28
100%
-148
- C1 -
-
4BDD
4
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
22
Blastp_CBE
74.28
100%
-136
- C1 -
-
4BDJ
1
CHK2_HUMAN
A:
[9-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
--
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------
11
PsiBlast_PDB
74.28
100%
-134
- C1 -
-
2CN5
1
CHK2_HUMAN
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
R
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
---------------------------------------
593
HHSearch
74.21
100%
-131
- C1 -
-
2YCF
1
CHK2_HUMAN
A:
[5-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
594
HHSearch
74.08
100%
-136
- C1 -
-
4BDC
2
CHK2_HUMAN
A:
[11-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
--
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
30
Blastp_CBE
74.08
100%
-141
- C1 -
-
4BDB
10
CHK2_HUMAN
A:
[8-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
--------------
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
--
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
13
PsiBlast_PDB
73.76
100%
-131
- C1 -
-
2WTC
1
CHK2_HUMAN
A:
[9-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
36
Blastp_CBE
73.67
99%
-136
- C1 -
-
2YCR
1
CHK2_HUMAN
A:
[3-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
-
G
E
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
---------------------------------
3
PsiBlast_PDB
73.43
100%
-136
- C1 -
-
2W0J
1
CHK2_HUMAN
A:
[2-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
-
T
A
L
P
Q
---------------------------------
17
PsiBlast_PDB
73.41
100%
-129
- C1 -
-
2XBJ
1
CHK2_HUMAN
A:
[9-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
-------------
A
L
-
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
9
PsiBlast_PDB
72.94
100%
-134
- C1 -
-
2YCS
1
CHK2_HUMAN
A:
[2-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
12
PsiBlast_PDB
70.00
100%
-137
- C1 -
-
2CN8
1
CHK2_HUMAN
A:
[10-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
--
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
---------
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
----------------------------------------
18
PsiBlast_PDB
67.83
100%
-141
- C1 -
-
2XM8
1
CHK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
--
L
R
D
E
Y
-
I
M
S
K
-
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
----------------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
-
K
-
N
F
F
-
D
A
-------
E
-
D
-
Y
-
Y
-------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
-
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
-
L
-
I
K
I
T
D
F
G
H
S
-
K
-
I
---
L
---
T
S
L
---
M
R
-
T
L
C
G
---
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
--
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
--
H
------
R
T
Q
V
S
--
L
K
D
--------------
Q
-
I
----
T
S
---
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
----
L
R
H
P
W
L
----
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
----------------------------------------
52
Blastp_CBE
50.55
34%
-17
- C1 -
-
5XZV
1
?
B:
[66-467]
----------------------------------------------------------------------------------------------------------------
W
T
F
G
R
N
P
A
C
D
Y
--------
H
L
G
N
I
S
R
L
S
N
K
H
F
Q
I
L
--
L
G
E
D
G
N
L
L
--
L
N
D
I
S
T
N
G
T
W
L
N
G
Q
K
V
E
K
N
S
N
Q
L
L
S
Q
G
D
E
I
T
V
G
V
-----
I
L
S
L
V
I
F
I
N
D
K
FKQCLEQ----------
N
K
T
GI
F
K
D
F
S
-
I
I
D
E
-
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
---
S
K
R
K
-----
M
D
-------
G
V
T
-------
R
---
E
L
E
V
L
Q
K
L
-
N
-
H
P
--
R
I
V
R
L
-
K
-
G
F
Y
E
D
T
-------
E
-
S
-
Y
-
Y
-------
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
--
A
H
-
G
A
----
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
-
L
I
-
E
Q
D
D
P
V
-
L
-
V
K
I
T
D
F
G
L
---------------------
T
F
C
G
T
L
A
Y
V
A
P
E
V
I
---------RN
E
Y
S
S
L
-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
-
S
---
G
------
S
T
Q
D
Q
--
L
Y
K
--------------
Q
-
I
----
G
R
---
G
S
Y
H
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
-----
T
A
A
K
A
----
L
N
H
P
W
I
----
V
----------------------------------------------------------------
41
Blastp_CBE
49.47
43%
-77
- C1 -
-
4FG7
1
KCC1A_HUMAN
A:
[16-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
-
D
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
-----------------
S
M
E
-------
N
---
E
I
A
V
L
H
K
I
-
K
-
H
P
--
N
I
V
A
L
-
D
-
D
I
Y
-
E
S
-------
G
-
G
-
H
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
-
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
Y
S
L
D
E
D
S
-
K
-
I
M
I
S
D
F
G
L
S
-
K
-
M
---
E
-
D
P
------------
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
----
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
---------
E
N
D
A
K
--
L
F
E
--------------
Q
-
I
----
L
K
---
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
----
L
Q
H
P
W
I
---------------------------------------------------------------------
51
Blastp_CBE
49.41
43%
-78
- C1 -
-
6T6F
1
?
A:
[20-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
---
P
K
K
A
L
---
K
G
K
E
S
-----
S
I
E
-------
N
---
E
I
A
V
L
R
K
I
-
K
-
H
E
--
N
I
V
A
L
-
E
-
D
I
Y
-
E
S
-------
P
-
N
-
H
L
Y
-------
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
-
G
F
----
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
Y
S
Q
D
E
E
S
-
K
-
I
M
I
S
D
F
G
L
S
-------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
--
E
------
N
D
S
-
K
--
L
F
E
--------------
Q
-
I
----
L
K
---
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
----
A
R
H
P
W
I
---------------------------------------------------------------------
280
Blastp_CBE
48.89
37%
-69
- C1 -
-
4REW
1
AAPK1_HUMAN
A:
[7-398]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
44
Blastp_CBE
48.87
43%
-84
- C1 -
-
4FG8
1
KCC1A_HUMAN
B:
[16-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
-
D
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
K
--------------------------
N
---
E
I
A
V
L
H
K
I
-
K
-
H
P
--
N
I
V
A
L
-
D
-
D
I
Y
-
E
S
-------
G
-
G
-
H
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
-
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
Y
S
L
D
E
D
S
-
K
-
I
M
I
S
D
F
G
-------------
G
S
V
---
L
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
---------
E
N
D
A
K
--
L
F
E
--------------
Q
-
I
----
L
K
---
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
----
L
Q
H
P
W
I
---------------------------------------------------------------------
222
Blastp_CBE
48.75
37%
-66
- C1 -
-
6C9H
2
AAPK1_HUMAN
A:
[15-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
50
Blastp_CBE
48.43
43%
-76
- C1 -
-
6T6F
1
?
B:
[20-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
---
P
K
K
A
L
---
K
G
K
E
S
-----
S
I
E
-------
N
---
E
I
A
V
L
R
K
I
-
K
-
H
E
--
N
I
V
A
L
-
E
-
D
I
Y
-
E
S
-------
P
-
N
-
H
L
Y
-------
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
-
G
F
----
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
Y
S
Q
D
E
E
S
-
K
-
I
M
I
S
D
F
G
---------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
--
E
------
N
D
S
-
K
--
L
F
E
--------------
Q
-
I
----
L
K
---
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
----
A
R
H
P
W
I
---------------------------------------------------------------------
210
Blastp_CBE
47.89
36%
-93
- C1 -
-
6BX6
1
AAPK2_HUMAN
A:
[12-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
V
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
K
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
T
-
D
-
F
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
H
-
G
R
----
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
--------------------------
N
Y
A
A
P
E
---------
Y
A
--
G
--
P
E
-
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
E
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
R
G
---
G
V
F
-
Y
I
P
E
Y
---
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
------------------------------------------------------
113
Blastp_CBE
47.85
39%
-47
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
T
D
E
Y
-
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
-
G
-
F
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
S
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
120
Blastp_CBE
47.81
39%
-40
- C1 -
-
6AYW
2
KCC2D_HUMAN
B:
[13-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
-
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
-
G
-
F
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
S
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
53
Blastp_CBE
47.61
34%
-9
- C1 -
-
5XZV
1
RAD53_YEAST
A:
[66-465]
----------------------------------------------------------------------------------------------------------------
W
T
F
G
R
N
P
A
C
D
Y
--------
H
------
L
S
N
K
H
F
Q
I
L
--
L
G
E
D
G
N
L
L
--
L
N
D
I
S
T
N
G
T
W
L
N
G
Q
K
V
E
K
N
S
N
Q
L
L
S
Q
G
D
E
I
T
V
G
V
---
S
D
I
L
S
L
V
I
F
I
N
D
K
FKQCLEQNKVDRIR----
K
T
GI
F
K
D
F
S
-
I
I
D
E
-
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
---
S
K
R
K
-
V
I
G
N
M
D
-------
G
V
T
-------
R
---
E
L
E
V
L
Q
K
L
-
N
-
H
P
--
R
I
V
R
L
-
K
-
G
F
Y
E
D
T
-------
E
-
S
-
Y
-
Y
-------
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
--
A
H
-
G
A
----
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
-
L
I
-
E
Q
D
D
P
V
-
L
-
V
K
I
T
D
F
G
L
A
-
K
-----------------------
L
A
Y
V
A
P
E
V
I
---------N-
E
Y
S
S
L
-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
------------
S
T
Q
D
Q
--
L
Y
K
--------------
Q
-
I
----
G
R
---
G
S
-----
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
---
D
P
N
N
-------
T
A
A
K
A
----
L
N
H
P
W
----------------------------------------------------------------------
54
Blastp_CBE
47.47
43%
-54
- C1 -
-
3LIJ
1
?
A:
[35-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
E
M
Y
-
Q
R
V
K
-
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
-----
R
K
-----
S
S
N
S
-----
K
L
L
-------
E
---
E
V
A
V
L
K
L
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
D
F
F
E
D
K
-------
R
-
N
-
Y
-
Y
-------
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
--
H
R
-
M
K
----
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
E
K
D
A
-
L
-
I
K
I
V
D
F
G
L
S
-
A
-
V
---
F
-
E
N
Q
K
K
---
M
K
-
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
K
--
K
Y
D
E
K
-
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
-
G
G
--
Q
------
T
D
Q
E
I
--
L
R
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
-----
S
A
Q
Q
A
----
L
E
H
P
W
I
----
K
E
---------------------------------------------------------------
604
HHSearch
47.42
45%
-86
- C1 -
-
2W4O
1
KCC4_HUMAN
A:
[51-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
D
F
F
-
E
V
E
S
-
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
---
K
K
-------------------------------
I
G
V
L
L
R
L
-
S
-
H
P
--
N
I
I
K
L
-
K
-
E
I
F
-
E
T
-------
P
-
T
E
I
-
S
-------
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
--
E
K
-
G
Y
----
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
A
T
P
A
P
D
A
-
P
-
L
K
I
A
D
F
--------------------------
G
T
P
G
Y
C
A
P
E
I
L
---
R
G
---
C
--
A
Y
G
P
E
-
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
-
Y
D
--
E
------
R
G
D
Q
F
--
M
F
R
--------------
R
-
I
----
L
N
---
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
-----
T
T
F
Q
A
----
L
Q
H
P
W
V
----
T
G
--------
K
A
-----------------------------------------------------
205
Blastp_CBE
47.38
36%
-83
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[12-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
V
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
K
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
T
-
D
-
F
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
H
-
G
R
----
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
-------
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
E
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
R
G
---
G
V
F
-
Y
I
P
E
Y
---
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
------------------------------------------------------
569
Blastp_CBE
47.25
35%
-39
- C1 -
-
2CKE
1
DAPK2_HUMAN
B:
[8-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
--
V
E
D
F
Y
-
D
I
G
E
-
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
S
R
--
A
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
S
I
L
R
Q
V
-
L
-
H
H
--
N
V
I
T
L
-
H
-
D
V
Y
-
E
N
-------
R
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
Q
K
-
E
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
-
M
L
L
D
K
N
I
P
I
P
H
-
I
K
L
I
D
F
G
L
A
-
H
-
E
---
I
-
E
D
G
V
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
I
----
T
S
---
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
----
L
R
H
P
W
I
----
T
P
--------
V
D
-----------------------------------------------------
570
Blastp_CBE
47.19
35%
-39
- C1 -
-
2CKE
1
DAPK2_HUMAN
A:
[8-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
--
V
E
D
F
Y
-
D
I
G
E
-
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
S
R
--
A
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
S
I
L
R
Q
V
-
L
-
H
H
--
N
V
I
T
L
-
H
-
D
V
Y
-
E
N
-------
R
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
Q
K
-
E
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
-
M
L
L
D
K
N
I
P
I
P
H
-
I
K
L
I
D
F
G
L
A
-
H
-
E
---
I
-
E
D
G
V
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
I
----
T
S
---
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
----
L
R
H
P
W
I
----
T
P
--------
V
D
-----------------------------------------------------
49
Blastp_CBE
47.24
43%
-84
- C1 -
-
2JC6
1
KCC1D_HUMAN
A:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
---
P
K
K
A
--------
S
-----
S
I
E
-------
N
---
E
I
A
V
L
R
K
I
-
K
-
H
E
--
N
I
V
A
L
-
E
-
D
I
Y
-
E
S
-------
P
-
N
-
H
L
Y
-------
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
-
G
F
----
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
Y
S
Q
D
E
E
S
-
K
-
I
M
I
S
------------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
--
E
------
N
D
S
-
K
--
L
F
E
--------------
Q
-
I
----
L
K
---
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
----
A
R
H
P
W
I
---------------------------------------------------------------------
567
Blastp_CBE
47.19
35%
-43
- C1 -
-
2CKE
1
DAPK2_HUMAN
D:
[8-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
--
V
E
D
F
Y
-
D
I
G
E
-
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
S
R
--
A
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
S
I
L
R
Q
V
-
L
-
H
H
--
N
V
I
T
L
-
H
-
D
V
Y
-
E
N
-------
R
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
Q
K
-
E
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
-
M
L
L
D
K
N
I
P
I
P
H
-
I
K
L
I
D
F
G
L
A
-
H
-
E
---
I
-
E
D
G
V
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
I
----
T
S
---
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
----
L
R
H
P
W
I
----
T
P
--------
V
D
-----------------------------------------------------
122
Blastp_CBE
46.99
39%
-39
- C1 -
-
5VLO
2
KCC2D_HUMAN
B:
[13-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
-
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
-
G
-
F
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
S
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
58
Blastp_CBE
46.98
40%
-62
- C1 -
-
2W4O
1
KCC4_HUMAN
A:
[50-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
S
D
F
F
-
E
V
E
S
-
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
---
K
K
-------------------------------
I
G
V
L
L
R
L
-
S
-
H
P
--
N
I
I
K
L
-
K
-
E
I
F
-
E
T
P------
T
-
E
-
I
-
S
-------
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
--
E
K
-
G
Y
----
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
A
T
P
A
P
D
A
-
P
-
L
K
I
A
D
F
--------------------------
G
T
P
G
Y
C
A
P
E
I
L
---
R
G
---
C
--
A
Y
G
P
E
-
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
-
Y
D
--
E
------
R
G
D
Q
F
--
M
F
R
--------------
R
-
I
----
L
N
---
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
-----
T
T
F
Q
A
----
L
Q
H
P
W
V
----
T
G
KAANFVHM
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
------------------------------
123
Blastp_CBE
46.90
39%
-44
- C1 -
-
5VLO
2
KCC2D_HUMAN
A:
[13-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
-
Q
L
F
E
-
E
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
-
G
-
F
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
S
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
43
Blastp_CBE
46.83
43%
-80
- C1 -
-
4FG9
1
KCC1A_HUMAN
A:
[16-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
-
D
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
K
E
-----------------
E
-------
N
---
E
I
A
V
L
H
K
I
-
K
-
H
P
--
N
I
V
A
L
-
D
-
D
I
Y
-
E
S
-------
G
-
G
-
H
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
-
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
Y
S
L
D
E
D
S
-
K
-
I
M
I
S
D
F
----------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
---------
E
N
D
A
K
--
L
F
E
--------------
Q
-
I
----
L
K
---
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
----
L
Q
H
P
W
I
---------------------------------------------------------------------
42
Blastp_CBE
46.83
43%
-89
- C1 -
-
4FG9
1
KCC1A_HUMAN
B:
[16-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
-
D
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
K
E
------------------------------
I
A
V
L
H
K
I
-
K
-
H
P
--
N
I
V
A
L
-
D
-
D
I
Y
-
E
S
-------
G
-
G
-
H
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
-
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
Y
S
L
D
E
D
S
-
K
-
I
M
I
S
D
F
----------------
V
---
L
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
---------
E
N
D
A
K
--
L
F
E
--------------
Q
-
I
----
L
K
---
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
----
L
Q
H
P
W
I
---------------------------------------------------------------------
339
Blastp_CBE
46.81
36%
-36
- C1 -
-
2UZU
1
KAPCA_BOVIN
E:
[27-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
W
-------
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
W
I
A
I
Y
Q
-----------------------------------------------
340
Blastp_CBE
46.76
36%
-39
- C1 -
-
2UZT
1
KAPCA_BOVIN
A:
[27-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
W
-------
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
W
I
A
I
Y
Q
-----------------------------------------------
125
Blastp_CBE
46.76
40%
-53
- C1 -
-
4YZB
1
?
B:
[27-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
F
S
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
---
S
K
R
--------
Q
K
T
D
K
E
-
L
L
L
-------
K
---
E
V
E
L
L
K
K
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
N
K
R
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
S
T
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
---
G
------
A
N
E
F
D
--
I
L
K
--------------
K
-
V
----
E
K
---
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
----
L
E
H
E
W
L
----
K
T
--------
T
D
-----------------------------------------------------
121
Blastp_CBE
46.61
39%
-43
- C1 -
-
6AYW
2
KCC2D_HUMAN
A:
[13-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
-
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
-
G
-
F
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
S
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
310
Blastp_CBE
46.59
36%
-38
- C1 -
-
3DFC
1
DAPK1_HUMAN
B:
[11-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
150
Blastp_CBE
46.58
35%
-61
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
T
--
I
T
E
R
Y
-
K
V
G
R
-
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
---
K
K
S
K
C
---
R
G
K
E
H
-----
M
I
Q
-------
N
---
E
V
S
I
L
R
R
V
-
K
-
H
P
--
N
I
V
L
L
-
I
-
E
E
M
-
D
V
P------
T
-
E
-
L
-
Y
-------
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
--
S
T
-
N
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
-
L
V
Y
E
H
Q
D
G
S
-
K
S
L
K
L
G
D
F
G
L
A
-
T
-
I
---
V
---
D
G
P
---
L
Y
-
T
V
C
G
T
P
T
Y
V
A
P
E
I
------
I
A
E
T
--
G
Y
G
L
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
S
----------
D
Q
E
V
--
L
F
D
--------------
Q
-
I
----
L
M
---
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
----
L
E
H
P
W
V
----
N
----------------------------------------------------------------
307
Blastp_CBE
46.51
37%
-37
- C1 -
-
2F7E
1
KAPCA_BOVIN
E:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
W
-------
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
149
Blastp_CBE
46.49
35%
-61
- C1 -
-
5JZN
1
B:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
T
--
I
T
E
R
Y
-
K
V
G
R
-
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
---
K
K
S
K
C
---
R
G
K
E
H
-----
M
I
Q
-------
N
---
E
V
S
I
L
R
R
V
-
K
-
H
P
--
N
I
V
L
L
-
I
-
E
E
M
-
D
V
P------
T
-
E
-
L
-
Y
-------
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
--
S
T
-
N
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
-
L
V
Y
E
H
Q
D
G
S
-
K
S
L
K
L
G
D
F
G
L
A
-
T
-
I
---
V
---
D
G
P
---
L
Y
-
T
V
C
G
T
P
T
Y
V
A
P
E
I
------
I
A
E
T
--
G
Y
G
L
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
S
-----------
Q
E
V
--
L
F
D
--------------
Q
-
I
----
L
M
---
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
----
L
E
H
P
W
V
----
N
----------------------------------------------------------------
335
Blastp_CBE
46.48
36%
-43
- C1 -
-
5AUU
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-----
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
338
Blastp_CBE
46.46
36%
-31
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[27-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
W
-------
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
W
I
A
I
Y
Q
-----------------------------------------------
289
Blastp_CBE
46.47
36%
-38
- C1 -
-
4YPD
1
DAPK1_HUMAN
A:
[10-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
Q
--------------------------------------------------
153
Blastp_CBE
46.46
35%
-66
- C1 -
-
5JZJ
1
B:
[31-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
T
--
I
T
E
R
Y
-
K
V
G
R
-
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
---
K
K
S
K
-----
C
R
G
K
E
H
M
---
I
Q
-------
N
---
E
V
S
I
L
R
R
V
-
K
-
H
P
--
N
I
V
L
L
-
I
-
E
E
M
-
D
V
P------
T
-
E
-
L
-
Y
-------
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
--
S
T
-
N
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
-
L
V
Y
E
H
Q
D
G
S
-
K
S
L
K
L
G
D
F
G
L
A
-
T
-
I
---
V
---
D
G
P
---
L
Y
-
T
V
C
G
T
P
T
Y
V
A
P
E
I
------
I
A
E
T
--
G
Y
G
L
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R--------------
E
V
--
L
F
D
--------------
Q
-
I
----
L
M
---
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
----
L
E
H
P
W
V
----
N
----------------------------------------------------------------
66
Blastp_CBE
46.46
41%
-63
- C1 -
-
3IGO
8
?
A:
[30-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
---
N
K
-----
A
S
A
K
N
K
-
T
S
--
T
I
L
-------
R
---
E
V
E
L
L
K
K
L
-
D
-
H
P
--
N
I
M
K
L
-
F
-
E
I
L
E
D
S
-------
S
-
S
-
F
-
Y
-------
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
--
K
R
-
K
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
E
S
K
E
K
D
C
-
D
-
I
K
I
I
D
F
G
L
S
-
T
-
C
---
F
-
Q
Q
N
T
-----------
T
A
Y
Y
I
A
P
E
V
L
-------
R
G
--
T
Y
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
---
G
------
K
N
E
Y
D
--
I
L
K
--------------
R
-
V
----
E
T
---
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
----
L
E
H
P
W
I
----
Q
----------------------------------------------------------------
299
Blastp_CBE
46.42
36%
-38
- C1 -
-
3GU5
1
DAPK1_HUMAN
A:
[11-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
300
Blastp_CBE
46.40
36%
-39
- C1 -
-
3GU4
1
DAPK1_HUMAN
A:
[11-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
306
Blastp_CBE
46.37
37%
-36
- C1 -
-
2F7X
1
KAPCA_BOVIN
E:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
W
-------
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
116
Blastp_CBE
46.35
39%
-40
- C1 -
-
6BAB
1
KCC2D_MOUSE
D:
[13-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
-
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
-
G
-
F
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
S
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
62
Blastp_CBE
46.35
41%
-55
- C1 -
-
4IEB
1
?
A:
[49-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
---
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
-
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
302
Blastp_CBE
46.33
36%
-36
- C1 -
-
3F5U
1
DAPK1_HUMAN
A:
[11-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
292
Blastp_CBE
46.33
36%
-40
- C1 -
-
3EHA
1
DAPK1_HUMAN
A:
[10-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
--
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
291
Blastp_CBE
46.31
36%
-39
- C1 -
-
3F5G
1
DAPK1_HUMAN
A:
[10-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
--
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
337
Blastp_CBE
46.27
36%
-36
- C1 -
-
2UZW
1
KAPCA_BOVIN
E:
[27-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
W
-------
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
W
I
A
I
Y
Q
-----------------------------------------------
57
Blastp_CBE
46.20
43%
-61
- C1 -
-
3HZT
9
?
A:
[3-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
-
Q
R
V
K
-
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
---
K
K
S
S
V
T
T
T
S
N
S
G
A
------
L
L
-------
D
---
E
V
A
V
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
E
D
K
-------
R
-
N
-
Y
-
Y
-------
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
--
L
R
-
Q
K
----
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
R
D
A
-
L
-
I
K
I
V
D
F
G
L
S
-
A
-
H
---
F
-
E
V
------------
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
K
--
K
Y
D
E
K
-
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
-
G
G
--
Q
------
T
D
Q
E
I
--
L
K
---------------
R
-
V
----
E
K
---
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
A
E
E
A
----
L
N
H
P
W
I
---------------------------------------------------------------------
154
Blastp_CBE
46.19
35%
-61
- C1 -
-
5JZJ
2
DCLK1_HUMAN
A:
[31-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
T
--
I
T
E
R
Y
-
K
V
G
R
-
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
---
K
K
S
K
-----
C
R
G
K
E
H
M
---
I
Q
-------
N
---
E
V
S
I
L
R
R
V
-
K
-
H
P
--
N
I
V
L
L
-
I
-
E
E
M
-
D
V
P------
T
-
E
-
L
-
Y
-------
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
--
S
T
-
N
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
-
L
V
Y
E
H
Q
D
G
S
-
K
S
L
K
L
G
D
F
G
L
A
-
T
-
I
---
V
---
D
G
P
---
L
Y
-
T
V
C
G
T
P
T
Y
V
A
P
E
I
------
I
A
E
T
--
G
Y
G
L
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
S
------------
E
V
--
L
F
D
--------------
Q
-
I
----
L
M
---
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
----
L
E
H
P
W
V
----
N
----------------------------------------------------------------
334
Blastp_CBE
46.18
36%
-43
- C1 -
-
5AUV
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
--
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
298
Blastp_CBE
46.12
36%
-39
- C1 -
-
3GU6
1
DAPK1_HUMAN
A:
[11-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
48
Blastp_CBE
46.10
43%
-85
- C1 -
-
2JC6
1
KCC1D_HUMAN
C:
[28-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
---
P
K
K
A
--------------
S
I
E
-------
N
---
E
I
A
V
L
R
K
I
-
K
-
H
E
--
N
I
V
A
L
-
E
-
D
I
Y
-
E
S
-------
P
-
N
-
H
L
Y
-------
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
-
G
F
----
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
Y
S
Q
D
E
E
S
-
K
-
I
M
I
S
------------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
--
E
------
N
D
S
-
K
--
L
F
E
--------------
Q
-
I
----
L
K
---
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
----
A
R
H
P
W
I
---------------------------------------------------------------------
524
Blastp_CBE
46.04
35%
-42
- C1 -
-
2YAA
1
DAPK2_MOUSE
B:
[8-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
--
V
E
D
F
Y
-
D
I
G
E
-
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
S
R
--
A
S
R
R
G
V
C
R
E
-
E
I
E
-------
R
---
E
V
S
I
L
R
Q
V
-
L
-
H
P
--
N
I
I
T
L
-
H
-
D
V
Y
-
E
N
-------
R
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
Q
K
-
E
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
-
M
L
L
D
K
N
I
P
I
P
H
-
I
K
L
I
D
F
G
L
A
-
H
-
E
---
I
-
E
D
G
V
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
I
----
T
A
---
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
----
L
R
H
P
W
I
----
T
P
--------
V
D
T
Q
Q
--------------------------------------------------
303
Blastp_CBE
46.08
37%
-39
- C1 -
-
2OJF
1
KAPCA_BOVIN
E:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
W
-------
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
304
Blastp_CBE
46.04
37%
-36
- C1 -
-
2OH0
1
KAPCA_BOVIN
E:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
W
-------
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
317
Blastp_CBE
46.03
36%
-39
- C1 -
-
2Y0A
1
DAPK1_HUMAN
A:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
Q
--------------------------------------------------
320
Blastp_CBE
46.02
36%
-38
- C1 -
-
2XUU
1
DAPK1_HUMAN
A:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
A
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
Q
--------------------------------------------------
336
Blastp_CBE
45.99
36%
-45
- C1 -
-
5AUT
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-----
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
119
Blastp_CBE
45.99
39%
-42
- C1 -
-
6BAB
2
KCC2D_MOUSE
A:
[13-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
-
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
-
G
-
F
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
S
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
45
Blastp_CBE
45.97
43%
-77
- C1 -
-
4FG8
1
KCC1A_HUMAN
A:
[16-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
-
D
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
K
E
-------------------------
N
---
E
I
A
V
L
H
K
I
-
K
-
H
P
--
N
I
V
A
L
-
D
-
D
I
Y
-
E
S
-------
G
-
G
-
H
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
-
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
Y
S
L
D
E
D
S
-
K
-
I
M
I
S
D
F
---------------------------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
---------
E
N
D
A
K
--
L
F
E
--------------
Q
-
I
----
L
K
---
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
----
L
Q
H
P
W
I
---------------------------------------------------------------------
333
Blastp_CBE
45.96
36%
-44
- C1 -
-
5AUW
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
387
Blastp_CBE
45.94
36%
-38
- C1 -
-
4UV0
1
DAPK1_HUMAN
A:
[13-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
Q
--------------------------------------------------
157
Blastp_CBE
45.93
37%
-44
- C1 -
-
2V7O
3
KCC2G_HUMAN
A:
[31-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
-
Q
L
F
E
-
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
-
G
-
F
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
C
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
E
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
K
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
D
Q
A
----
L
K
H
P
W
V
---------------------------------------------------------------------
319
Blastp_CBE
45.90
36%
-41
- C1 -
-
6QMO
7
DAPK1_HUMAN
A:
[14-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
Q
--------------------------------------------------
294
Blastp_CBE
45.80
36%
-41
- C1 -
-
1JKL
1
DAPK1_HUMAN
A:
[10-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
91
Blastp_CBE
45.79
41%
-52
- C1 -
-
4ONA
1
?
A:
[26-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
98
Blastp_CBE
45.74
41%
-55
- C1 -
-
3UPX
1
?
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
200
Blastp_CBE
45.71
36%
-47
- C1 -
-
5A6N
4
DAPK3_HUMAN
A:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
R
R
L
S
--
S
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
A
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
63
Blastp_CBE
45.68
41%
-59
- C1 -
-
4Y5Q
1
?
A:
[30-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
---
N
K
-----
A
S
A
K
N
K
D
T
S
--
T
I
L
-------
R
---
E
V
E
L
L
K
K
L
-
D
-
H
P
--
N
I
M
K
L
-
F
-
E
I
L
E
D
S
-------
S
-
S
-
F
-
Y
-------
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
--
K
R
-
K
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
E
S
K
E
K
D
C
-
D
-
I
K
I
I
D
F
G
L
S
-
T
-
C
---
F
-
Q
Q
N
T
-------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
G
--
T
Y
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
---
G
------
K
N
E
Y
D
--
I
L
K
--------------
R
-
V
----
E
T
---
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
----
L
E
H
P
W
I
----
Q
----------------------------------------------------------------
326
Blastp_CBE
45.64
36%
-45
- C1 -
-
5AV3
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
--
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
139
Blastp_CBE
45.63
39%
-23
- C1 -
-
3MFS
1
CSKP_HUMAN
A:
[22-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
-
E
L
C
E
-
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
---
D
V
A
K
F
T
------
S
S
P
G
L
-
S
T
E
-------
D
LKR
E
A
S
I
C
H
M
L
-
K
-
H
P
--
H
I
V
E
L
-
L
-
E
T
Y
-
S
S
-------
D
-
G
-
M
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
--
K
R
-
A
D
AGFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
L
A
S
K
E
N
S
A
-
P
-
V
K
L
G
D
F
G
V
A
-
I
-
Q
---
L
-
G
E
S
G
L
---
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
------
V
K
R
E
--
P
Y
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
-----
Y
------
G
T
K
E
R
--
L
F
E
--------------
G
-
I
----
I
K
---
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
----
L
N
H
P
W
L
----
K
E
--------
R
D
-----------------------------------------------------
331
Blastp_CBE
45.61
36%
-42
- C1 -
-
5AUY
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
--
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
568
Blastp_CBE
45.54
35%
-36
- C1 -
-
2CKE
1
DAPK2_HUMAN
C:
[8-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
--
V
E
D
F
Y
-
D
I
G
E
-
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
S
R
--
A
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
S
I
L
R
Q
V
-
L
-
H
H
--
N
V
I
T
L
-
H
-
D
V
Y
-
E
N
-------
R
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
Q
K
-
E
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
-
M
L
L
D
K
N
I
P
I
P
H
-
I
K
L
I
D
F
G
L
A
-
H
-
E
---
I
-
E
D
G
V
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
I
----
T
S
---
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
----
L
R
H
P
W
I
----
T
P
--------
V
D
-----------------------------------------------------
327
Blastp_CBE
45.58
36%
-44
- C1 -
-
5AV2
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
--
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
138
Blastp_CBE
45.58
39%
-25
- C1 -
-
3MFU
1
CSKP_HUMAN
A:
[22-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
-
E
L
C
E
-
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
---
D
V
A
K
F
T
------
S
S
P
G
L
-
S
T
E
-------
D
LKR
E
A
S
I
C
H
M
L
-
K
-
H
P
--
H
I
V
E
L
-
L
-
E
T
Y
-
S
S
-------
D
-
G
-
M
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
--
K
R
-
A
D
AGFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
L
A
S
K
E
N
S
A
-
P
-
V
K
L
G
D
F
G
V
A
-
I
-
Q
---
L
-
G
E
S
G
L
---
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
------
V
K
R
E
--
P
Y
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
-----
Y
------
G
T
K
E
R
--
L
F
E
--------------
G
-
I
----
I
K
---
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
----
L
N
H
P
W
L
----
K
E
--------
R
D
-----------------------------------------------------
73
Blastp_CBE
45.58
41%
-55
- C1 -
-
3HX4
3
?
A:
[50-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
-------
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
----
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
297
Blastp_CBE
45.57
36%
-38
- C1 -
-
3GU7
1
DAPK1_HUMAN
A:
[11-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
67
Blastp_CBE
45.55
42%
-53
- C1 -
-
4MXA
1
?
A:
[27-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
E
D
K
-------
G
-
Y
-
Y
-
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
----
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
344
Blastp_CBE
45.54
36%
-37
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[13-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
Q
--------------------------------------------------
325
Blastp_CBE
45.53
36%
-44
- C1 -
-
5AV4
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-----
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
99
Blastp_CBE
45.50
41%
-54
- C1 -
-
3T3V
2
?
A:
[26-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
88
Blastp_CBE
45.48
41%
-50
- C1 -
-
4WG4
1
?
A:
[26-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
118
Blastp_CBE
45.45
39%
-38
- C1 -
-
6BAB
2
KCC2D_MOUSE
B:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
-
Q
L
F
E
-
E
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
-
G
-
F
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
S
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
525
Blastp_CBE
45.42
35%
-39
- C1 -
-
2YAA
1
DAPK2_MOUSE
A:
[8-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
--
V
E
D
F
Y
-
D
I
G
E
-
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
---
K
K
R
Q
S
R
--
A
S
R
R
G
V
C
R
E
-
E
I
E
-------
R
---
E
V
S
I
L
R
Q
V
-
L
-
H
P
--
N
I
I
T
L
-
H
-
D
V
Y
-
E
N
-------
R
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
Q
K
-
E
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
-
M
L
L
D
K
N
I
P
I
P
H
-
I
K
L
I
D
F
G
L
A
-
H
-
E
---
I
-
E
D
G
V
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
I
----
T
A
---
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
----
L
R
H
P
W
I
----
T
P
--------
V
D
T
Q
Q
--------------------------------------------------
87
Blastp_CBE
45.37
41%
-49
- C1 -
-
4WG5
1
?
A:
[26-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
80
Blastp_CBE
45.34
41%
-54
- C1 -
-
6BFA
1
?
A:
[26-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
332
Blastp_CBE
45.32
36%
-42
- C1 -
-
5AUX
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
--
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
195
Blastp_CBE
45.32
36%
-50
- C1 -
-
5VJA
2
DAPK3_HUMAN
B:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
--------
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
A
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
330
Blastp_CBE
45.31
36%
-45
- C1 -
-
5AUZ
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
-----
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
82
Blastp_CBE
45.29
41%
-53
- C1 -
-
5W9E
1
?
A:
[26-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
68
Blastp_CBE
45.28
42%
-58
- C1 -
-
4MX9
1
?
A:
[27-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
E
D
K
-------
G
-
Y
-
Y
-
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
----
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
295
Blastp_CBE
45.27
36%
-43
- C1 -
-
1JKK
1
DAPK1_HUMAN
A:
[10-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
------------------------------------------------------
86
Blastp_CBE
45.23
41%
-52
- C1 -
-
4YJN
1
?
A:
[26-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
59
Blastp_CBE
45.20
40%
-57
- C1 -
-
2WEI
1
?
A:
[22-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
Y
-
N
I
V
C
-
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
---
N
K
-----
A
S
A
K
N
K
D
T
S
--
T
I
L
-------
R
---
E
V
E
L
L
K
K
L
-
D
-
H
P
--
N
I
M
K
L
-
F
-
E
I
L
E
D
S
-------
S
-
S
-
F
-
Y
-------
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
--
K
R
-
K
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
E
S
K
E
K
D
C
-
D
-
I
K
I
I
D
F
G
L
S
-
T
-
C
---
F
-
Q
Q
N
T
K
---
M
K
-
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
G
--
T
Y
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
---
G
------
K
N
E
Y
D
--
I
L
K
--------------
R
-
V
----
E
T
---
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
----
L
E
H
P
W
I
----
Q
----------------------------------------------------------------
293
Blastp_CBE
45.19
36%
-42
- C1 -
-
3EH9
1
DAPK1_HUMAN
A:
[10-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
-
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
--
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
193
Blastp_CBE
45.14
36%
-50
- C1 -
-
5VJA
3
DAPK3_HUMAN
D:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
R
R
L
S
-------
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
-----
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
A
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
341
Blastp_CBE
45.13
36%
-38
- C1 -
-
4TXC
7
DAPK1_HUMAN
A:
[30-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
198
Blastp_CBE
45.12
36%
-45
- C1 -
-
5A6O
3
DAPK3_HUMAN
A:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
R
R
L
S
--
S
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
--------
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
196
Blastp_CBE
45.09
36%
-48
- C1 -
-
5VJA
2
DAPK3_HUMAN
A:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
R
-------
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
A
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
322
Blastp_CBE
45.07
36%
-38
- C1 -
-
6QN4
4
DAPK1_HUMAN
A:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
132
Blastp_CBE
45.06
40%
-49
- C1 -
-
4YSJ
1
?
A:
[27-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
F
S
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
---
S
K
R
----------------
L
L
-------
K
---
E
V
E
L
L
K
K
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
N
K
R
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
S
T
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
---
G
------
A
N
E
F
D
--
I
L
K
--------------
K
-
V
----
E
K
---
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
----
L
E
H
E
W
L
----
K
T
--------
T
D
-----------------------------------------------------
92
Blastp_CBE
45.05
41%
-55
- C1 -
-
4M84
1
?
A:
[26-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
329
Blastp_CBE
45.01
36%
-43
- C1 -
-
5AV0
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
--
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
316
Blastp_CBE
44.97
36%
-37
- C1 -
-
2YAK
1
DAPK1_HUMAN
A:
[11-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
------------------------------------------------------
61
Blastp_CBE
44.91
41%
-59
- C1 -
-
3MA6
1
?
A:
[32-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
-
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
194
Blastp_CBE
44.90
36%
-47
- C1 -
-
5VJA
2
DAPK3_HUMAN
C:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
R
R
L
S
--
S
---
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
----
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
A
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
507
Blastp_CBE
44.86
35%
-39
- C1 -
-
3GUB
1
DAPK1_HUMAN
A:
[11-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
-----------------------------------------------------
70
Blastp_CBE
44.85
41%
-48
- C1 -
-
4IH8
1
?
A:
[49-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
--
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
----
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
100
Blastp_CBE
44.83
41%
-51
- C1 -
-
3T3U
5
?
A:
[26-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
290
Blastp_CBE
44.82
36%
-39
- C1 -
-
4YO4
1
DAPK1_HUMAN
A:
[10-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
-
T
Q
Q
--------------------------------------------------
296
Blastp_CBE
44.81
36%
-40
- C1 -
-
1IG1
1
DAPK1_HUMAN
A:
[10-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
---------------------------------------------------
95
Blastp_CBE
44.78
41%
-51
- C1 -
-
3V5P
1
?
A:
[26-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
81
Blastp_CBE
44.78
41%
-51
- C1 -
-
5W9R
1
?
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
324
Blastp_CBE
44.76
36%
-40
- C1 -
-
6AAR
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
--------------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
---------------------------------------------------------------
71
Blastp_CBE
44.72
41%
-46
- C1 -
-
4IFG
1
?
A:
[49-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
----
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
188
Blastp_CBE
44.71
37%
-43
- C1 -
-
3SOA
1
KCC2A_HUMAN
A:
[11-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
Y
-
Q
L
F
E
-
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
G
H
-
H
-
Y
-------
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
-
L
L
A
S
K
L
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
E
-
G
E
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
-----
T
A
A
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
202
Blastp_CBE
44.70
36%
-49
- C1 -
-
3BHY
1
DAPK3_HUMAN
A:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
R
R
L
S
--
S
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
------------
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
305
Blastp_CBE
44.68
37%
-35
- C1 -
-
2F7Z
1
KAPCA_BOVIN
E:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
W
-------
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
508
Blastp_CBE
44.63
35%
-35
- C1 -
-
3GU8
1
DAPK1_HUMAN
A:
[11-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
-----------------------------------------------------
199
Blastp_CBE
44.61
36%
-45
- C1 -
-
5A6N
1
DAPK3_HUMAN
B:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
R
R
L
S
--
S
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
--------
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
347
Blastp_CBE
44.57
36%
-33
- C1 -
-
6FHB
2
DAPK1_HUMAN
A:
[14-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
Q
--------------------------------------------------
468
Blastp_CBE
44.54
36%
-39
- C1 -
-
2W4J
1
DAPK1_HUMAN
A:
[11-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
----------------------------------------------------------------
197
Blastp_CBE
44.57
36%
-45
- C1 -
-
5A6O
2
DAPK3_HUMAN
B:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
R
R
L
S
--
S
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
--------
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
83
Blastp_CBE
44.56
41%
-49
- C1 -
-
5W91
1
?
A:
[26-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
77
Blastp_CBE
44.54
41%
-52
- C1 -
-
5JN2
1
?
A:
[67-342]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
----
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
65
Blastp_CBE
44.53
41%
-62
- C1 -
-
3MWU
1
?
A:
[30-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
---
N
K
-----
A
S
A
K
N
K
D
T
S
--
T
I
L
-------
R
---
E
V
E
L
L
K
K
L
-
D
-
H
P
--
N
I
M
K
L
-
F
-
E
I
L
E
D
S
-------
S
-
S
-
F
-
Y
-------
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
--
K
R
-
K
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
E
S
K
E
K
D
C
-
D
-
I
K
I
I
D
F
G
L
S
-
T
-
C
---
F
-
Q
Q
N
--------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
G
--
T
Y
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
---
G
------
K
N
E
Y
D
--
I
L
K
--------------
R
-
V
----
E
T
---
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
----
L
E
H
P
W
I
----
Q
----------------------------------------------------------------
56
Blastp_CBE
44.51
39%
-95
- C1 -
-
4PDS
1
RAD53_YEAST
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
I
F
K
D
F
S
I
I
D
E
--------------
V
--------------------------
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
----------------------
V
T
-------
R
---
E
L
E
V
L
Q
K
L
-
N
-
H
P
--
R
I
V
R
L
-
K
-
G
F
Y
----------
E
-
S
-
Y
-
Y
-------
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
--
A
H
-
G
A
----
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
-
L
I
-
E
Q
D
D
P
V
-
L
-
V
K
I
T
A
F
G
L
A
-
K
-
V
----------------------
A
Y
V
A
P
E
V
I
---
R
-----RN
E
Y
S
S
L
-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
-
S
---
G
------
S
T
Q
D
Q
--
L
Y
K
--------------
Q
-
I
----
G
R
---
G
S
Y
H
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
-----
T
A
A
K
A
----
L
N
H
P
W
I
----
K
----------------------------------------------------------------
64
Blastp_CBE
44.45
41%
-61
- C1 -
-
3NCG
1
?
A:
[30-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
---
N
K
-----
A
S
A
K
N
K
D
T
S
--
T
I
L
-------
R
---
E
V
E
L
L
K
K
L
-
D
-
H
P
--
N
I
M
K
L
-
F
-
E
I
L
E
D
S
-------
S
-
S
-
F
-
Y
-------
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
--
K
R
-
K
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
E
S
K
E
K
D
C
-
D
-
I
K
I
I
D
F
G
L
S
-
T
-
C
---
F
-
Q
Q
N
T
---------
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
G
--
T
Y
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
---
G
------
K
N
E
Y
D
--
I
L
K
--------------
R
-
V
----
E
T
---
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
----
L
E
H
P
W
I
----
Q
----------------------------------------------------------------
74
Blastp_CBE
44.32
41%
-52
- C1 -
-
5T6K
1
?
A:
[67-358]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
-
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
----
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
483
Blastp_CBE
44.31
36%
-38
- C1 -
-
1WVY
1
DAPK1_HUMAN
A:
[11-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
----------------------------------------------------------------
465
Blastp_CBE
44.26
36%
-41
- C1 -
-
4PF4
6
DAPK1_HUMAN
A:
[12-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
----------------------------------------------------------------
78
Blastp_CBE
44.20
41%
-50
- C1 -
-
5JMS
2
?
A:
[67-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
----
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
349
Blastp_CBE
44.13
35%
-53
- C1 -
-
2J90
2
DAPK3_HUMAN
A:
[20-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
--
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
R
R
L
S
--
S
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
-------------
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
I
A
-
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
117
Blastp_CBE
43.94
39%
-42
- C1 -
-
6BAB
2
KCC2D_MOUSE
C:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
-
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
S
E
-------
E
-
G
-
F
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
S
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
Q
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
--
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
Q
--------------
Q
-
I
----
K
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
101
Blastp_CBE
43.92
41%
-48
- C1 -
-
3SXF
3
?
A:
[26-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
85
Blastp_CBE
43.87
41%
-48
- C1 -
-
5W80
1
?
A:
[26-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
201
Blastp_CBE
43.76
36%
-47
- C1 -
-
3BQR
4
DAPK3_HUMAN
A:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
---
K
K
R
R
L
S
--
S
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
A
G
N
-------
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
76
Blastp_CBE
43.70
41%
-48
- C1 -
-
5T6A
1
?
A:
[67-358]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
-
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
----
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
311
Blastp_CBE
43.62
36%
-30
- C1 -
-
2W4K
1
DAPK1_HUMAN
A:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
T
Q
Q
--------------------------------------------------
111
Blastp_CBE
43.61
38%
-37
- C1 -
-
5FG8
3
KCC2A_DROME
A:
[14-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
Y
-
D
I
K
E
-
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
---
N
T
K
K
L
---
T
A
R
D
F
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
K
L
-
H
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
Q
E
-------
E
-
N
-
Y
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
F
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
A
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
H
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
K
E
--
P
Y
G
K
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
S
--------------
Q
-
I
----
K
A
---
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
301
Blastp_CBE
43.57
36%
-36
- C1 -
-
1P4F
1
DAPK1_HUMAN
A:
[10-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
--------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
--
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
F
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
P
--------
K
D
-----------------------------------------------------
509
Blastp_CBE
43.53
36%
-69
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[17-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
R
L
L
R
-
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
---
D
K
T
Q
L
N
P
S
S
L
Q
K
-------
L
F
-------
R
---
E
V
R
I
M
K
G
L
-
N
-
H
P
--
N
I
V
K
L
-
F
-
E
V
I
-
E
T
-------
E
-
K
T
L
-
Y
-------
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
--
S
H
-
G
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
-
L
L
D
A
E
A
N
-----
I
K
I
A
D
F
G
F
S
-
N
----------------------
S
P
P
Y
A
A
P
E
L
F
---
Q
G
K
K
Y
D
--
G
--
P
E
-
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
G
--
H
------
N
L
K
-
E
--
L
R
E
--------------
R
-
V
----
L
R
---
G
K
Y
R
----
V
P
F
Y
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
-----
T
L
E
Q
I
----
M
K
D
K
W
I
----
N
----------------------------------------------------------------
75
Blastp_CBE
43.52
41%
-53
- C1 -
-
5T6I
1
?
A:
[67-361]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
--
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
-
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
----
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
103
Blastp_CBE
43.49
41%
-46
- C1 -
-
3N51
3
?
A:
[26-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
60
Blastp_CBE
43.45
41%
-53
- C1 -
-
3MA6
1
?
B:
[32-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
-
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
112
Blastp_CBE
43.41
38%
-37
- C1 -
-
5HU3
1
KCC2A_DROME
A:
[14-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
Y
-
D
I
K
E
-
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
---
N
T
K
K
L
---
T
A
R
D
F
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
K
L
-
H
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
Q
E
-------
E
-
N
-
Y
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
F
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
-
L
L
A
S
K
A
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
H
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
K
E
--
P
Y
G
K
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
S
--------------
Q
-
I
----
K
A
---
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
206
Blastp_CBE
43.39
37%
-38
- C1 -
-
4CZU
3
CIPKN_ARATH
D:
[12-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
-
E
L
G
R
-
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
---
D
K
E
K
-----
V
L
K
N
K
M
I
A
-
Q
I
K
-------
R
---
E
I
S
T
M
K
L
I
-
K
-
H
P
--
N
V
I
R
M
-
F
-
E
V
M
-
A
S
-------
K
T
K
-
I
-
Y
-------
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
--
S
N
-
G
R
----
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
---
N
G
-
A
-
L
K
V
S
D
F
G
L
S
-
A
-
L
PQQ
V
-
R
E
D
G
L
---
L
H
-
D
T
C
G
T
P
N
Y
V
A
P
E
V
------
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
------
S
N
L
T
S
--
L
Y
K
--------------
K
-
I
----
F
K
---
A
E
F
T
C
P
P
--
W
F
S
A
S
A
K
K
--
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
----
I
E
N
E
W
F
----
K
K
--------
G
Y
K
A
P
K
F
E
N
----------------------------------------------
190
Blastp_CBE
43.34
37%
-40
- C1 -
-
4CZT
3
CIPKN_ARATH
C:
[12-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
-
E
L
G
R
-
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
---
D
K
E
K
-----
V
L
K
N
K
M
I
A
-
Q
I
K
-------
R
---
E
I
S
T
M
K
L
I
-
K
-
H
P
--
N
V
I
R
M
-
F
-
E
V
M
-
A
S
-------
K
T
K
-
I
-
Y
-------
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
--
S
N
-
G
R
----
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
---
N
G
-
A
-
L
K
V
S
D
F
G
L
S
-
A
-
L
PQQ
V
-
R
E
D
G
L
---
L
H
-
T
T
C
G
T
P
N
Y
V
A
P
E
V
------
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
------
S
N
L
T
S
--
L
Y
K
--------------
K
-
I
----
F
K
---
A
E
F
T
C
P
P
--
W
F
S
A
S
A
K
--
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
----
I
E
N
E
W
F
----
K
K
--------
G
Y
K
A
P
K
F
E
N
----------------------------------------------
104
Blastp_CBE
43.34
41%
-46
- C1 -
-
3I7B
4
?
A:
[26-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
-
E
A
S
K
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------
208
Blastp_CBE
43.15
37%
-39
- C1 -
-
4CZU
3
CIPKN_ARATH
B:
[12-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
-
E
L
G
R
-
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
---
D
K
E
K
-----
V
L
K
N
K
M
I
A
-
Q
I
K
-------
R
---
E
I
S
T
M
K
L
I
-
K
-
H
P
--
N
V
I
R
M
-
F
-
E
V
M
-
A
S
-------
K
T
K
-
I
-
Y
-------
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
--
S
N
-
G
R
----
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
---
N
G
-
A
-
L
K
V
S
D
F
G
L
S
-
A
-
L
PQQ
V
-
R
E
D
G
L
---
L
H
-
D
T
C
G
T
P
N
Y
V
A
P
E
V
------
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
------
S
N
L
T
S
--
L
Y
K
--------------
K
-
I
----
F
K
---
A
E
F
T
C
P
P
--
W
F
S
A
S
A
K
K
--
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
----
I
E
N
E
W
F
----
K
K
--------
G
Y
K
A
P
K
F
E
N
----------------------------------------------
110
Blastp_CBE
43.10
38%
-37
- C1 -
-
5H9B
2
KCC2A_DROME
A:
[14-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
Y
-
D
I
K
E
-
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
---
N
T
K
K
L
---
T
A
R
D
F
Q
----
K
L
E
-------
R
---
E
A
R
I
C
R
K
L
-
H
-
H
P
--
N
I
V
R
L
-
H
-
D
S
I
-
Q
E
-------
E
-
N
-
Y
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
-
E
F
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
-
L
L
A
S
K
A
K
G
A
-
A
-
V
K
L
A
D
F
G
L
A
I
E
-
V
---
Q
-
G
D
H
Q
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
K
E
--
P
Y
G
K
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-
W
D
---------
E
D
Q
H
R
--
L
Y
S
--------------
Q
-
I
----
K
A
---
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
----
L
K
H
P
W
I
---------------------------------------------------------------------
216
Blastp_CBE
43.08
38%
-66
- C1 -
-
5KZ8
1
MARK2_HUMAN
A:
[35-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
R
L
L
K
-
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
---
D
K
T
Q
L
N
S
S
S
L
Q
K
-------
L
F
-------
R
---
E
V
R
I
M
K
V
L
-
N
-
H
P
--
N
I
V
K
L
-
F
-
E
V
I
-
E
T
-------
E
-
K
T
L
-
Y
-------
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
--
A
H
-
G
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
-
L
L
D
A
---
D
M
-
N
-
I
K
I
A
D
F
G
------------------------
C
G
S
P
P
Y
A
A
P
E
L
F
---
Q
G
K
K
Y
D
--
G
--
P
E
-
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
G
--
Q
------
N
L
K
-
E
--
L
R
E
--------------
R
-
V
----
L
R
---
G
K
Y
R
-
I
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
----
M
K
D
R
W
M
NVGH
E
D
--------
D
E
L
K
---------------------------------------------------
189
Blastp_CBE
43.04
37%
-37
- C1 -
-
4CZT
4
CIPKN_ARATH
D:
[12-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
-
E
L
G
R
-
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
---
D
K
E
K
-----
V
L
K
N
K
M
I
A
-
Q
I
K
-------
R
---
E
I
S
T
M
K
L
I
-
K
-
H
P
--
N
V
I
R
M
-
F
-
E
V
M
-
A
S
-------
K
T
K
-
I
-
Y
-------
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
--
S
N
-
G
R
----
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
---
N
G
-
A
-
L
K
V
S
D
F
G
L
S
-
A
-
L
PQQ
V
-
R
E
D
G
L
---
L
H
-
T
T
C
G
T
P
N
Y
V
A
P
E
V
------
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
------
S
N
L
T
S
--
L
Y
K
--------------
K
-
I
----
F
K
---
A
E
F
T
C
P
P
--
W
F
S
A
S
A
K
--
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
----
I
E
N
E
W
F
----
K
K
--------
G
Y
K
A
P
K
F
E
N
----------------------------------------------
514
Blastp_CBE
42.80
37%
-38
- C1 -
-
6E4U
2
AAPK1_RAT
A:
[17-406]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
191
Blastp_CBE
42.79
37%
-37
- C1 -
-
4CZT
2
CIPKN_ARATH
B:
[12-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
-
E
L
G
R
-
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
---
D
K
E
K
-----
V
L
K
N
K
M
I
A
-
Q
I
K
-------
R
---
E
I
S
T
M
K
L
I
-
K
-
H
P
--
N
V
I
R
M
-
F
-
E
V
M
-
A
S
-------
K
T
K
-
I
-
Y
-------
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
--
S
N
-
G
R
----
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
L
D
A
---
N
G
-
A
-
L
K
V
S
D
F
G
L
S
-
A
-
L
PQQ
V
-
R
E
D
G
L
---
L
H
-
T
T
C
G
T
P
N
Y
V
A
P
E
V
------
I
N
N
K
--
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
------
S
N
L
T
S
--
L
Y
K
--------------
K
-
I
----
F
K
---
A
E
F
T
C
P
P
--
W
F
S
A
S
A
K
--
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
----
I
E
N
E
W
F
----
K
K
--------
G
Y
K
A
P
K
F
E
N
----------------------------------------------
513
Blastp_CBE
42.71
37%
-39
- C1 -
-
6E4W
2
?
A:
[17-410]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
47
Blastp_CBE
42.56
44%
-16
- C1 -
-
2JAM
3
KCC1G_HUMAN
A:
[7-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
K
T
F
-
I
F
M
E
-
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
---
K
K
---------------S
S
L
E
-------
N
---
E
I
A
V
L
K
K
I
-
K
-
H
E
--
N
I
V
T
L
-
E
-
D
I
Y
-
E
S
-------
T
T
H
-
Y
-
Y
-------
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
--
E
R
-
G
V
----
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
L
T
P
E
E
N
S
-
K
-
I
M
I
T
D
F
G
L
S
-
K
-----
M
-
E
Q
N
G
I
---
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
-
Y
E
---------
E
T
E
S
K
--
L
F
E
--------------
K
-
I
----
K
E
---
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
E
K
A
----
L
S
H
P
W
I
---------------------------------------------------------------------
312
Blastp_CBE
42.44
36%
-64
- C1 -
-
3ZXT
1
DAPK1_HUMAN
D:
[11-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------------
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
---------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
--------------
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
----------------------------------------------------------------
396
Blastp_CBE
42.42
36%
-41
- C1 -
-
5N32
3
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
-
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
46
Blastp_CBE
42.35
44%
-14
- C1 -
-
2JAM
3
KCC1G_HUMAN
B:
[7-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
K
T
F
-
I
F
M
E
-
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
---
K
K
---------------S
S
L
E
-------
N
---
E
I
A
V
L
K
K
I
-
K
-
H
E
--
N
I
V
T
L
-
E
-
D
I
Y
-
E
S
-------
T
T
H
-
Y
-
Y
-------
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
--
E
R
-
G
V
----
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
L
T
P
E
E
N
S
-
K
-
I
M
I
T
D
F
G
L
S
-
K
-----
M
-
E
Q
N
G
I
---
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
-
Y
E
---------
E
T
E
S
K
--
L
F
E
--------------
K
-
I
----
K
E
---
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
E
K
A
----
L
S
H
P
W
I
---------------------------------------------------------------------
174
Blastp_CBE
42.20
39%
-19
- C1 -
-
4D9U
1
A:
[22-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
Y
-
E
V
K
E
-
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
---
D
K
S
K
--------
R
D
P
T
------------
E
---
E
I
E
I
L
L
R
Y
-
G
Q
H
P
--
N
I
I
T
L
-
K
-
D
V
Y
-
D
D
-------
G
-
K
-
Y
V
Y
-------
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
--
R
Q
-
K
F
----
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y
V
D
E
S
G
N
P
E
S
-
I
R
I
C
D
F
G
F
A
-
K
-
Q
---
L
R
A
E
N
G
L
---
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
R
Q
--
G
Y
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
GP
D
------
D
T
P
E
E
--
I
L
A
--------------
R
-
I
----
G
S
---
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
A
L
V
----
L
R
H
P
W
I
----
V
H
--------
W
D
Q
L
P
Q
Y
Q
-----------------------------------------------
472
Blastp_CBE
42.16
36%
-44
- C1 -
-
1XH6
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
401
Blastp_CBE
42.12
36%
-41
- C1 -
-
5M75
2
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
404
Blastp_CBE
42.14
36%
-40
- C1 -
-
5M6V
1
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
218
Blastp_CBE
42.12
38%
-63
- C1 -
-
5KZ7
1
MARK2_HUMAN
A:
[35-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
R
L
L
K
-
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
---
D
K
T
Q
L
N
S
S
S
L
Q
K
-------
L
F
-------
R
---
E
V
R
I
M
K
V
L
-
N
-
H
P
--
N
I
V
K
L
-
F
-
E
V
I
-
E
T
-------
E
-
K
T
L
-
Y
-------
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
--
A
H
-
G
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
-
L
L
D
A
---
D
M
-
N
-
I
K
I
A
D
F
--------------------------
G
S
P
P
Y
A
A
P
E
L
F
---
Q
G
K
--
D
--
G
--
P
E
-
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
----------
N
L
K
-
E
--
L
R
E
--------------
R
-
V
----
L
R
---
G
K
Y
R
-
I
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
----
M
K
D
R
W
M
NVGH
E
D
--------
D
E
L
K
---------------------------------------------------
313
Blastp_CBE
42.06
36%
-45
- C1 -
-
3ZXT
1
DAPK1_HUMAN
C:
[11-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
--
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
S
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
---------------
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
----------------------------------------------------------------
211
Blastp_CBE
42.05
38%
-57
- C1 -
-
5EAK
1
MARK2_HUMAN
B:
[17-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
R
L
L
K
-
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
---
D
K
T
Q
L
N
S
S
S
L
Q
K
-------
L
F
-------
R
---
E
V
R
I
M
K
V
L
-
N
-
H
P
--
N
I
V
K
L
-
F
-
E
V
I
-
E
T
-------
E
-
K
T
L
-
Y
-------
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
--
A
H
-
G
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
-
L
L
D
A
---
D
M
-
N
-
I
K
I
A
D
F
G
-----------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
---
Q
G
K
K
Y
D
--
G
--
P
E
-
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
G
--
Q
------
N
L
K
-
E
--
L
R
E
--------------
R
-
V
----
L
R
---
G
K
Y
R
-
I
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
----
M
K
D
R
W
M
NVGH
E
D
--------
D
E
L
K
---------------------------------------------------
519
Blastp_CBE
42.04
37%
-39
- C1 -
-
4QFS
2
AAPK1_RAT
A:
[17-410]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
135
Blastp_CBE
42.01
39%
-17
- C1 -
-
1PHK
1
PHKG1_RABIT
A:
[23-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
---
D
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
-
E
A
T
-------
L
K--
E
V
D
I
L
R
K
V
-
S
G
H
P
--
N
I
I
Q
L
-
K
-
D
T
Y
-
E
T
-------
N
-
T
-
F
-
F
F------
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
--
E
K
-
V
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
---
D
D
D
M
-
N
-
I
K
L
T
D
F
G
F
S
-
C
-
Q
---
L
-
D
P
G
E
K
---
L
R
-
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
ECS
M
N
D
N
H
P
--
G
Y
G
K
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
-
W
---
H
------
R
K
Q
M
L
--
M
L
R
--------------
M
-
I
----
M
S
---
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
----
L
A
H
P
F
F
----
Q
----------------------------------------------------------------
158
Blastp_CBE
41.99
38%
-41
- C1 -
-
3F3Z
5
?
A:
[11-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
T
L
E
N
-
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
---
P
K
Y
-----
F
V
E
D
V
D
----
R
F
K
-------
Q
---
E
I
E
I
M
K
S
L
-
D
-
H
P
--
N
I
I
R
L
Y
E
-
T
F
E
-
D
N
-------
T
-
D
-
I
-
Y
-------
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
--
H
K
-
R
V
----
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
-
L
F
L
T
D
S
P
D
S
-
P
-
L
K
L
I
D
F
G
L
A
-
A
-
R
---
F
-
K
P
G
K
M
---
M
R
-
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
---
E
G
L
------
Y
G
P
E
-
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
-
S
A
--
P
------
T
D
E
V
M
--
L
K
-----------------
I
----
R
E
---
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
-----
T
S
L
Q
A
----
L
E
H
E
W
F
----
E
K
--------
Q
------------------------------------------------------
395
Blastp_CBE
41.97
36%
-40
- C1 -
-
5N7P
2
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
557
Blastp_CBE
41.96
37%
-40
- C1 -
-
4C35
2
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
348
Blastp_CBE
41.92
35%
-49
- C1 -
-
2J90
3
DAPK3_HUMAN
B:
[27-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
E
M
G
E
-
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
----
K
E
Y
A
A
K
F
I
---
K
K
R
R
L
S
--
S
S
R
R
G
V
S
R
E
-
E
I
E
-------
R
---
E
V
N
I
L
R
E
I
-
R
-
H
P
--
N
I
I
T
L
-
H
-
D
I
F
-
E
N
-------
K
T
D
-
V
-
V
-------
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
--
E
K
--
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
-
R
-
I
K
L
I
D
F
G
I
A
-
H
-
K
---
I
-
E
A
G
N
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
E
------
T
K
Q
E
T
--
L
T
N
----------------
I
----
S
A
---
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
I
A
-
Q
S
----
L
E
H
S
W
I
----
K
----------------------------------------------------------------
518
Blastp_CBE
41.87
37%
-39
- C1 -
-
5KQ5
2
?
A:
[17-408]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
460
Blastp_CBE
41.86
37%
-61
- C1 -
-
6B2E
2
AAPK2_HUMAN
A:
[28-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
V
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
K
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
T
-
D
-
F
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
H
-
G
R
----
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
E
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
R
G
---
G
V
F
-
Y
I
P
E
Y
---
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
----------------------------------------------------------------
388
Blastp_CBE
41.78
36%
-42
- C1 -
-
3L9N
1
KAPCA_HUMAN
A:
[42-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
516
Blastp_CBE
41.75
37%
-40
- C1 -
-
5UFU
2
AAPK1_MOUSE (first)
A:
[17-403]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
517
Blastp_CBE
41.74
37%
-36
- C1 -
-
5T5T
2
AAPK1_RAT
A:
[17-403]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
398
Blastp_CBE
41.70
36%
-37
- C1 -
-
5N1E
4
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
532
Blastp_CBE
41.63
37%
-41
- C1 -
-
4CFH
1
AAPK1_RAT
A:
[34-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
457
Blastp_CBE
41.63
36%
-43
- C1 -
-
1YDS
1
KAPCA_BOVIN
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
215
Blastp_CBE
41.61
38%
-54
- C1 -
-
5KZ8
1
MARK2_HUMAN
B:
[35-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
R
L
L
K
-
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
---
D
K
T
Q
L
N
S
S
S
L
Q
K
-------
L
F
-------
R
---
E
V
R
I
M
K
V
L
-
N
-
H
P
--
N
I
V
K
L
-
F
-
E
V
I
-
E
T
-------
E
-
K
T
L
-
Y
-------
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
--
A
H
-
G
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
-
L
L
D
A
---
D
M
-
N
-
I
K
I
A
D
F
--------------------------
G
S
P
P
Y
A
A
P
E
L
F
---
Q
G
K
K
Y
D
--
G
--
P
E
-
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
G
--
Q
------
N
L
K
-
E
--
L
R
E
--------------
R
-
V
----
L
R
---
G
K
Y
R
-
I
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
----
M
K
D
R
W
M
NVGH
E
D
--------
D
E
L
K
---------------------------------------------------
133
Blastp_CBE
41.56
39%
-17
- C1 -
-
1QL6
1
PHKG1_RABIT
A:
[23-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
---
D
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
-
E
A
T
-------
L
K--
E
V
D
I
L
R
K
V
-
S
G
H
P
--
N
I
I
Q
L
-
K
-
D
T
Y
-
E
T
-------
N
-
T
-
F
-
F
F------
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
--
E
K
-
V
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
---
D
D
D
M
-
N
-
I
K
L
T
D
F
G
F
S
-
C
-
Q
---
L
-
D
P
G
E
K
---
L
R
-
S
V
C
G
T
P
S
Y
L
A
P
E
I
I
ECS
M
N
D
N
H
P
--
G
Y
G
K
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
-
W
---
H
------
R
K
Q
M
L
--
M
L
R
--------------
M
-
I
----
M
S
---
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
----
L
A
H
P
F
F
----
Q
----------------------------------------------------------------
515
Blastp_CBE
41.54
37%
-37
- C1 -
-
6E4T
2
?
A:
[17-410]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
432
Blastp_CBE
41.53
36%
-39
- C1 -
-
6MM8
6
KAPCA_MOUSE
C:
[30-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
511
Blastp_CBE
41.46
36%
-42
- C1 -
-
2GNH
2
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
K
V
A
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
412
Blastp_CBE
41.45
36%
-38
- C1 -
-
5LCQ
3
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
136
Blastp_CBE
41.44
39%
-11
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[10-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
---
D
V
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
R
-
E
A
T
-------
L
K--
E
V
D
I
L
R
K
V
-
S
G
H
P
--
N
I
I
Q
L
-
K
-
D
T
Y
-
E
T
-------
N
-
T
-
F
-
F
F------
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
--
E
K
-
V
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
---
D
D
D
M
-
N
-
I
K
L
T
D
F
G
F
S
-
C
-
Q
---
L
-
D
P
G
E
K
---
L
R
-
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
ECS
M
N
D
N
H
P
--
G
Y
G
K
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
-
W
---
H
------
R
K
Q
M
L
--
M
L
R
--------------
M
-
I
----
M
S
---
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
----
L
A
H
P
F
F
----
Q
----------------------------------------------------------------
408
Blastp_CBE
41.39
36%
-39
- C1 -
-
5M0B
4
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
565
Blastp_CBE
41.36
36%
-38
- C1 -
-
4WB8
2
KAPCA_HUMAN
A:
[28-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
W
I
A
I
Y
Q
-----------------------------------------------
394
Blastp_CBE
41.39
36%
-36
- C1 -
-
5N7U
2
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
433
Blastp_CBE
41.37
36%
-40
- C1 -
-
6MM7
9
KAPCA_MOUSE
D:
[30-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
409
Blastp_CBE
41.36
36%
-43
- C1 -
-
5LCU
5
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
212
Blastp_CBE
41.31
38%
-52
- C1 -
-
5EAK
1
MARK2_HUMAN
A:
[17-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
R
L
L
K
-
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
---
D
K
T
Q
L
N
S
S
S
L
Q
K
-------
L
F
-------
R
---
E
V
R
I
M
K
V
L
-
N
-
H
P
--
N
I
V
K
L
-
F
-
E
V
I
-
E
T
-------
E
-
K
T
L
-
Y
-------
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
--
A
H
-
G
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
-
L
L
D
A
---
D
M
-
N
-
I
K
I
A
D
F
G
F
S
---------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
---
Q
G
K
K
Y
D
--
G
--
P
E
-
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
G
--
Q
------
N
L
K
-
E
--
L
R
E
--------------
R
-
V
----
L
R
---
G
K
Y
R
-
I
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
----
M
K
D
R
W
M
NVGH
E
D
--------
D
E
L
K
---------------------------------------------------
471
Blastp_CBE
41.29
36%
-39
- C1 -
-
1XH8
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
361
Blastp_CBE
41.27
36%
-39
- C1 -
-
4UJ2
2
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
528
Blastp_CBE
41.22
36%
-41
- C1 -
-
2GNF
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
K
V
A
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
480
Blastp_CBE
41.22
36%
-37
- C1 -
-
4YXR
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
368
Blastp_CBE
41.19
36%
-39
- C1 -
-
3OOG
1
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
425
Blastp_CBE
41.14
36%
-41
- C1 -
-
2QUR
1
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLPN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
541
Blastp_CBE
41.13
36%
-34
- C1 -
-
2JDT
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
T
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
453
Blastp_CBE
41.11
36%
-37
- C1 -
-
2C1B
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
556
Blastp_CBE
41.03
37%
-40
- C1 -
-
4C36
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
482
Blastp_CBE
41.08
36%
-39
- C1 -
-
3DND
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
454
Blastp_CBE
41.05
36%
-39
- C1 -
-
2C1A
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
440
Blastp_CBE
40.98
36%
-44
- C1 -
-
1BX6
1
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
500
Blastp_CBE
41.04
36%
-37
- C1 -
-
1SVG
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
410
Blastp_CBE
41.03
36%
-41
- C1 -
-
5LCT
4
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
543
Blastp_CBE
40.98
36%
-37
- C1 -
-
2GNJ
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
K
V
A
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
217
Blastp_CBE
41.01
38%
-57
- C1 -
-
5KZ7
1
MARK2_HUMAN
B:
[35-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
R
L
L
K
-
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
---
D
K
T
Q
L
N
S
S
S
L
Q
K
-------
L
F
-------
R
---
E
V
R
I
M
K
V
L
-
N
-
H
P
--
N
I
V
K
L
-
F
-
E
V
I
-
E
T
-------
E
-
K
T
L
-
Y
-------
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
--
A
H
-
G
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
-
L
L
D
A
---
D
M
-
N
-
I
K
I
A
D
F
--------------------------
G
S
P
P
Y
A
A
P
E
L
F
---
Q
G
K
--
D
--
G
--
P
E
-
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
-
D
----------
N
L
K
-
E
--
L
R
E
--------------
R
-
V
----
L
R
---
G
K
Y
R
-
I
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
----
M
K
D
R
W
M
NVGH
E
D
--------
D
E
L
K
---------------------------------------------------
501
Blastp_CBE
40.99
36%
-35
- C1 -
-
1SVE
2
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
353
Blastp_CBE
40.98
36%
-35
- C1 -
-
6C0U
4
KAPCA_HUMAN
A:
[45-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
558
Blastp_CBE
40.97
37%
-42
- C1 -
-
4C34
3
KAPCA_BOVIN
A:
[42-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
389
Blastp_CBE
40.95
36%
-35
- C1 -
-
3L9M
1
KAPCA_HUMAN
B:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
418
Blastp_CBE
40.92
36%
-40
- C1 -
-
4HPT
1
KAPCA_MOUSE
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
403
Blastp_CBE
40.92
36%
-41
- C1 -
-
5M6Y
2
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
367
Blastp_CBE
40.92
36%
-39
- C1 -
-
3OVV
2
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
411
Blastp_CBE
40.87
36%
-39
- C1 -
-
5LCR
6
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
402
Blastp_CBE
40.87
36%
-42
- C1 -
-
5M71
2
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
407
Blastp_CBE
40.85
36%
-40
- C1 -
-
5M0C
3
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
364
Blastp_CBE
40.87
36%
-38
- C1 -
-
3P0M
1
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
399
Blastp_CBE
40.85
36%
-38
- C1 -
-
5N1D
3
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
521
Blastp_CBE
40.81
37%
-38
- C1 -
-
4QFG
1
AAPK1_RAT
A:
[17-406]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
375
Blastp_CBE
40.85
36%
-39
- C1 -
-
3VQH
2
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
170
Blastp_CBE
40.82
39%
-27
- C1 -
-
4M8T
1
A:
[35-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
Y
-
E
V
K
E
-
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
---
D
K
S
K
--------
R
D
P
T
------------
E
---
E
I
E
I
L
L
R
Y
-
G
Q
H
P
--
N
I
I
T
L
-
K
-
D
V
Y
-
D
D
-------
G
-
K
-
Y
V
Y
-------
V
V
M
E
L
M
K
G
G
E
L
L
D
K
I
L
--
R
Q
-
K
F
----
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y
V
D
E
S
G
N
P
E
S
-
I
R
I
C
D
F
G
F
A
-
K
-
Q
---
L
R
A
E
N
G
L
---
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
R
Q
--
G
Y
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
GP
D
------
D
T
P
E
E
--
I
L
A
--------------
R
-
I
----
G
S
---
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
A
L
V
----
L
R
H
P
W
I
----
V
H
--------
W
D
Q
L
P
Q
Y
Q
-----------------------------------------------
363
Blastp_CBE
40.81
36%
-41
- C1 -
-
3POO
2
KAPCA_HUMAN
A:
[42-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
366
Blastp_CBE
40.80
36%
-40
- C1 -
-
3OWP
1
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
547
Blastp_CBE
40.78
36%
-35
- C1 -
-
4RER
2
AAPK1_HUMAN
A:
[7-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
560
Blastp_CBE
40.72
36%
-37
- C1 -
-
3AMA
1
KAPCA_HUMAN
A:
[42-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
R
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
Q
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
K
V
A
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
175
Blastp_CBE
40.77
39%
-16
- C1 -
-
4D9T
1
A:
[22-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
Y
-
E
V
K
E
-
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
---
D
K
S
K
--------
R
D
P
T
------------
E
---
E
I
E
I
L
L
R
Y
-
G
Q
H
P
--
N
I
I
T
L
-
K
-
D
V
Y
-
D
D
-------
G
-
K
-
Y
V
Y
-------
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
--
R
Q
-
K
F
----
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y
V
D
E
S
G
N
P
E
S
-
I
R
I
C
D
F
G
F
A
-
K
-
Q
---
L
R
A
E
N
G
L
---
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
R
Q
--
G
Y
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
GP
D
------
D
T
P
E
E
--
I
L
A
--------------
R
-
I
----
G
S
---
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
A
L
V
----
L
R
H
P
W
I
----
V
H
--------
W
D
Q
L
P
Q
Y
Q
-----------------------------------------------
422
Blastp_CBE
40.75
36%
-44
- C1 -
-
3IDC
1
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
406
Blastp_CBE
40.74
36%
-41
- C1 -
-
5M0L
3
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
405
Blastp_CBE
40.73
36%
-39
- C1 -
-
5M0U
8
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
----
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
438
Blastp_CBE
40.72
36%
-40
- C1 -
-
2ERZ
1
KAPCA_MOUSE
E:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
469
Blastp_CBE
40.68
36%
-38
- C1 -
-
4IJ9
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
400
Blastp_CBE
40.67
36%
-36
- C1 -
-
5MHI
4
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
473
Blastp_CBE
40.65
36%
-38
- C1 -
-
1XH5
3
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
390
Blastp_CBE
40.68
36%
-36
- C1 -
-
3L9M
1
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
413
Blastp_CBE
40.65
36%
-41
- C1 -
-
5LCP
3
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
314
Blastp_CBE
40.67
36%
-54
- C1 -
-
3ZXT
1
DAPK1_HUMAN
B:
[11-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
K
-
S
R
R
G
V
S
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
--------------
T
P
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
---
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
----------------------------------------------------------------
377
Blastp_CBE
40.65
36%
-38
- C1 -
-
3AGL
1
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
458
Blastp_CBE
40.64
36%
-38
- C1 -
-
1YDR
1
KAPCA_BOVIN
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
365
Blastp_CBE
40.63
36%
-39
- C1 -
-
3OXT
1
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
554
Blastp_CBE
40.57
37%
-39
- C1 -
-
4C37
2
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
559
Blastp_CBE
40.54
36%
-38
- C1 -
-
3AMB
1
KAPCA_HUMAN
A:
[42-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
R
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
Q
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
K
V
A
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
435
Blastp_CBE
40.57
36%
-43
- C1 -
-
6MM6
1
KAPCA_MOUSE
E:
[30-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
443
Blastp_CBE
40.56
36%
-38
- C1 -
-
3O7L
2
KAPCA_MOUSE
B:
[41-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
---
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
I
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
I
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
437
Blastp_CBE
40.55
36%
-37
- C1 -
-
6MM5
1
KAPCA_MOUSE
E:
[30-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
448
Blastp_CBE
40.54
36%
-39
- C1 -
-
6E99
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
520
Blastp_CBE
40.49
37%
-36
- C1 -
-
4QFR
2
?
A:
[17-410]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
-
I
L
G
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
---
N
R
Q
K
I
-----
R
S
L
D
V
V
G
-
K
I
R
-------
R
---
E
I
Q
N
L
K
L
F
-
R
-
H
P
--
H
I
I
K
L
-
Y
-
Q
V
I
-
S
T
P------
S
-
D
-
I
-
F
-------
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
--
K
N
-
G
R
----
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
N
-----
A
K
I
A
D
F
G
L
S
-
N
-
M
---
M
-
S
D
G
E
F
---
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
---
S
G
R
L
Y
A
--
G
--
P
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-
D
D
--
D
------
H
V
P
T
L
--
F
K
---------------
K
-
I
----
C
D
---
G
I
F
-
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
----
R
E
H
E
W
F
----
K
Q
--------
D
L
P
K
Y
L
F
------------------------------------------------
537
Blastp_CBE
40.50
36%
-33
- C1 -
-
2UW7
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
T
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
542
Blastp_CBE
40.45
36%
-40
- C1 -
-
2GNL
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
K
V
A
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
444
Blastp_CBE
40.49
36%
-41
- C1 -
-
4NTT
1
KAPCA_MOUSE
B:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
474
Blastp_CBE
40.48
36%
-34
- C1 -
-
1SVH
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
430
Blastp_CBE
40.46
36%
-37
- C1 -
-
1FMO
1
KAPCA_MOUSE
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
370
Blastp_CBE
40.45
36%
-41
- C1 -
-
3L9L
1
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
449
Blastp_CBE
40.44
36%
-34
- C1 -
-
4IE9
2
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
481
Blastp_CBE
40.42
36%
-34
- C1 -
-
3DNE
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
553
Blastp_CBE
40.41
37%
-39
- C1 -
-
4C38
4
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
529
Blastp_CBE
40.35
36%
-32
- C1 -
-
1XHA
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
E
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
L
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
551
Blastp_CBE
40.39
36%
-42
- C1 -
-
3QAL
1
KAPCA_MOUSE
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
A
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
456
Blastp_CBE
40.34
36%
-37
- C1 -
-
1YDT
1
KAPCA_BOVIN
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
452
Blastp_CBE
40.36
36%
-37
- C1 -
-
2VO7
2
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
376
Blastp_CBE
40.34
36%
-38
* C1 *
-
3AGL
1
KAPCA_HUMAN
B:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
540
Blastp_CBE
40.31
36%
-38
- C1 -
-
2JDV
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
T
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
510
Blastp_CBE
40.35
36%
-38
- C1 -
-
2GNI
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
K
V
A
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
359
Blastp_CBE
40.34
36%
-36
- C1 -
-
4UJA
2
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
504
Blastp_CBE
40.32
36%
-38
- C1 -
-
1Q8T
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
169
Blastp_CBE
40.31
39%
-27
- C1 -
-
4MAO
1
A:
[35-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
Y
-
E
V
K
E
-
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
---
D
K
S
K
--------
R
D
P
T
------------
E
---
E
I
E
I
L
L
R
Y
-
G
Q
H
P
--
N
I
I
T
L
-
K
-
D
V
Y
-
D
D
-------
G
-
K
-
Y
V
Y
-------
V
V
M
E
L
M
K
G
G
E
L
L
D
K
I
L
--
R
Q
-
K
F
----
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y
V
D
E
S
G
N
P
E
S
-
I
R
I
C
D
F
G
F
A
-
K
-
Q
---
L
R
A
E
N
G
L
---
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
R
Q
--
G
Y
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
GP
D
------
D
T
P
E
E
--
I
L
A
--------------
R
-
I
----
G
S
---
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
A
L
V
----
L
R
H
P
W
I
----
V
H
--------
W
D
Q
L
P
Q
Y
Q
-----------------------------------------------
354
Blastp_CBE
40.29
36%
-37
- C1 -
-
5UZK
1
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
503
Blastp_CBE
40.27
36%
-40
- C1 -
-
1Q8U
3
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
423
Blastp_CBE
40.23
36%
-38
- C1 -
-
3IDB
1
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
362
Blastp_CBE
40.22
36%
-38
- C1 -
-
4UJ1
2
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
420
Blastp_CBE
40.14
36%
-36
- C1 -
-
3OW3
1
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
351
Blastp_CBE
40.14
36%
-36
- C1 -
-
1CDK
2
KAPCA_PIG
B:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
Y
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
459
Blastp_CBE
40.11
37%
-34
- C1 -
-
1XH9
4
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
E
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
L
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
315
Blastp_CBE
40.09
36%
-48
- C1 -
-
3ZXT
1
DAPK1_HUMAN
A:
[11-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
-
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---
K
K
R
R
--
T
--------
R
E
-
D
I
E
-------
R
---
E
V
S
I
L
K
E
I
-
Q
-
H
P
--
N
V
I
T
L
-
H
-
E
V
Y
-
E
N
-------
K
T
D
-
V
-
I
-------
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
K
-
E
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
P
K
P
-
R
-
I
K
I
I
D
F
G
L
A
-
H
-
K
---
I
-
D
----------------
E
F
V
A
P
E
I
------
V
N
Y
E
--
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
-
L
G
--
D
------
T
K
Q
E
T
--
L
A
N
----------------
V
----
S
A
---
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
----
L
Q
H
P
W
I
----
K
----------------------------------------------------------------
485
Blastp_CBE
40.05
36%
-37
- C1 -
-
4Z83
2
KAPCA_BOVIN
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
445
Blastp_CBE
40.05
36%
-42
- C1 -
-
4NTT
1
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
397
Blastp_CBE
40.08
36%
-35
- C1 -
-
5N1K
3
KAPCA_CRIGR
A:
[44-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
439
Blastp_CBE
40.05
36%
-36
- C1 -
-
2GU8
1
KAPCA_HUMAN
A:
[28-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
---
D
E
Q
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
502
Blastp_CBE
40.01
36%
-41
- C1 -
-
1STC
1
KAPCA_BOVIN
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
369
Blastp_CBE
40.02
36%
-37
- C1 -
-
3L9L
1
KAPCA_HUMAN
B:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
417
Blastp_CBE
40.01
36%
-35
- C1 -
-
3MVJ
1
KAPCA_HUMAN
A:
[62-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
374
Blastp_CBE
40.00
36%
-37
- C1 -
-
4UJB
3
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
352
Blastp_CBE
39.97
36%
-39
- C1 -
-
1CDK
2
KAPCA_PIG
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
Y
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
548
Blastp_CBE
39.93
36%
-40
- C1 -
-
3QAM
1
KAPCA_MOUSE
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
A
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
428
Blastp_CBE
39.92
36%
-35
- C1 -
-
1RE8
2
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
563
Blastp_CBE
39.85
36%
-38
- C1 -
-
4WB5
1
KAPCA_HUMAN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
424
Blastp_CBE
39.84
36%
-39
- C1 -
-
3FJQ
1
KAPCA_MOUSE
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
373
Blastp_CBE
39.80
36%
-37
- C1 -
-
5BX6
4
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
450
Blastp_CBE
39.74
36%
-37
- C1 -
-
3ZO4
4
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
391
Blastp_CBE
39.77
36%
-43
- C1 -
-
6F14
2
KAPCA_CRIGR
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
F
-
D
R
I
K
-
T
L
G
T
----
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
372
Blastp_CBE
39.76
36%
-38
- C1 -
-
5BX7
4
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
419
Blastp_CBE
39.74
36%
-39
- C1 -
-
4DIN
1
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
447
Blastp_CBE
39.72
36%
-34
- C1 -
-
6E9L
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
564
Blastp_CBE
39.66
36%
-40
- C1 -
-
1RDQ
3
KAPCA_MOUSE
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
A
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
552
Blastp_CBE
39.60
36%
-35
- C1 -
-
3FHI
1
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
A
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
479
Blastp_CBE
39.60
36%
-36
- C1 -
-
4YXS
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
545
Blastp_CBE
39.59
36%
-36
- C1 -
-
1Q24
1
KAPCA_BOVIN
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
546
Blastp_CBE
39.56
36%
-30
- C1 -
-
2VO0
4
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
T
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
536
Blastp_CBE
39.49
36%
-28
- C1 -
-
4AXA
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
T
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
427
Blastp_CBE
39.46
36%
-36
- C1 -
-
1REJ
1
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
415
Blastp_CBE
39.45
36%
-35
- C1 -
-
3MVJ
1
KAPCA_HUMAN
E:
[62-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
P
----
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
426
Blastp_CBE
39.42
36%
-34
- C1 -
-
1REK
2
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
539
Blastp_CBE
39.40
36%
-32
- C1 -
-
2UVX
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
T
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
441
Blastp_CBE
39.30
36%
-45
- C1 -
-
1BKX
1
KAPCA_MOUSE
A:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
506
Blastp_CBE
39.27
36%
-35
- C1 -
-
1JBP
2
KAPCA_MOUSE
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
E
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
431
Blastp_CBE
39.25
36%
-37
- C1 -
-
1ATP
1
KAPCA_MOUSE
E:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
266
Blastp_CBE
39.22
36%
-25
- C1 -
-
2JBO
1
MAPK2_HUMAN
A:
[20-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
DR
G
D
-
Q
A
----
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
-
T
------------
C
Y
T
P
Y
Y
V
A
P
E
V
L
------
G
P
E
--
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
--
H
------
G
L
A
I
S
PG
M
K
T
--------------
R
-
I
----
R
M
---
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
538
Blastp_CBE
39.11
36%
-29
- C1 -
-
2UW4
1
KAPCA_BOVIN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
-
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
T
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
D
Q
Q
---
G
-
Y
-
I
K
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
601
HHSearch
39.07
32%
-16
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[90-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
-
S
K
T
E
-
I
L
-----
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
---
K
T
R
G
M
--------
K
D
K
E
-
E
V
K
-------
N
---
E
I
S
V
M
N
Q
L
-
D
-
H
A
--
N
L
I
Q
L
-
Y
-
D
A
F
-
E
S
-------
K
-
N
D
I
-
V
-------
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
--
D
E
S
Y
N
----
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
-
L
C
V
N
R
-
D
A
K
-
Q
-
I
K
I
I
D
F
G
L
A
-
R
-
R
---
Y
-
K
P
R
E
K
---
L
K
-
V
N
F
G
T
P
E
F
L
A
P
E
V
V
---
N
Y
---
D
--
F
V
S
F
P
-
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
-
L
G
--
D
------
N
D
A
E
---
T
L
N
--------------
N
-
I
----
L
A
---
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
-----
S
A
S
E
A
----
L
K
H
P
W
L
----
S
D
--------
H
K
L
H
S
--------------------------------------------------
531
Blastp_CBE
39.06
36%
-35
- C1 -
-
4WB6
1
KAPCA_HUMAN
B:
[41-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
R
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
----
K
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
124
Blastp_CBE
38.61
40%
1
- C1 -
-
3Q5I
1
?
A:
[38-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
F
K
V
R
-
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
---
K
K
-------------------KFHEEIY
N
---
E
I
S
L
L
K
S
L
-
D
-
H
P
--
N
I
I
K
L
-
F
-
D
V
F
E
D
K
-------
K
-
Y
-
F
-
Y
-------
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
--
N
R
-
H
K
----
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
-
L
L
E
N
K
N
S
L
L
-
N
-
I
K
I
V
D
F
G
L
S
-
S
-
F
---
F
-
S
K
D
Y
K
---
L
R
-
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-------
K
K
--
K
Y
N
E
K
-
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
-
G
G
--
Q
------
N
D
Q
D
I
--
I
K
---------------
K
-
V
----
E
K
---
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
-----
T
A
E
E
A
----
L
N
S
R
W
I
----
K
----------------------------------------------------------------
172
Blastp_CBE
38.49
39%
-17
- C1 -
-
4JG7
1
A:
[35-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
Y
-
E
V
K
E
-
D
I
G
V
--
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
---
D
K
S
K
--------
R
D
P
T
------------
E
---
E
I
E
I
L
L
R
Y
-
G
Q
H
P
--
N
I
I
T
L
-
K
-
D
V
Y
-
D
D
-------
G
-
K
-
Y
V
Y
-------
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
--
R
Q
-
K
F
----
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y
V
D
E
S
G
N
P
E
S
-
I
R
I
C
D
F
G
F
A
-
K
-
Q
---
L
R
A
E
N
G
L
---
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
R
Q
--
G
Y
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
GP
D
------
D
T
P
E
E
--
I
L
A
--------------
R
-
I
----
G
S
---
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
A
L
V
----
L
R
H
P
W
I
----
V
H
--------
W
D
Q
L
P
Q
Y
Q
-----------------------------------------------
173
Blastp_CBE
38.45
39%
-20
- C1 -
-
4JG6
1
A:
[35-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
Y
-
E
V
K
E
-
D
I
-----
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
---
D
K
S
K
--------
R
D
P
T
------------
E
---
E
I
E
I
L
L
R
Y
-
G
Q
H
P
--
N
I
I
T
L
-
K
-
D
V
Y
-
D
D
-------
G
-
K
-
Y
V
Y
-------
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
--
R
Q
-
K
F
----
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y
V
D
E
S
G
N
P
E
S
-
I
R
I
C
D
F
G
F
A
-
K
-
Q
---
L
R
A
E
N
G
L
---
L
M
-
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
R
Q
--
G
Y
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
GP
D
------
D
T
P
E
E
--
I
L
A
--------------
R
-
I
----
G
S
---
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
A
L
V
----
L
R
H
P
W
I
----
V
H
--------
W
D
Q
L
P
Q
Y
Q
-----------------------------------------------
321
Blastp_CBE
38.28
37%
-32
- C1 -
-
3NX8
3
KAPCA_HUMAN
A:
[42-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
-
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
---
D
K
Q
K
--
V
V
K
L
K
Q
I
E
H
T
L
-
N
-------------
E
K
R
I
L
Q
A
V
-
N
-
F
P
--
F
L
V
K
L
-
E
F
S
F
K
-
D
N
-------
S
-
N
-
L
-
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
--
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
D
Q
Q
---
G
-
Y
-
I
Q
V
T
D
F
G
F
A
-
K
R
V
---
K
-
G
R
T
--------
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
---
L
S
---
K
--
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-
F
A
--
D
------
Q
P
-
I
Q
--
I
Y
E
--------------
K
-
I
----
V
S
---
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
-----
G
N
L
K
N
GVND
I
N
H
K
W
F
----
A
T
--------
T
D
-----------------------------------------------------
177
Blastp_CBE
38.12
39%
-17
- C1 -
-
5O1S
2
A:
[44-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
Y
-
E
V
K
E
-
D
I
-----
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
---
D
K
S
K
--------
R
D
P
T
------------
E
---
E
I
E
I
L
L
R
Y
-
G
Q
H
P
--
N
I
I
T
L
-
K
-
D
V
Y
-
D
D
-------
G
-
K
-
Y
V
Y
-------
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
--
R
Q
-
K
F
----
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y
V
D
E
S
G
N
P
E
S
-
I
R
I
C
D
F
G
F
A
-
K
-
Q
---
L
R
A
E
N
G
L
---
L
M
-
T
P
C
---
N
F
V
A
P
E
V
L
---
E
R
---
Q
--
G
Y
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
GP
D
------
D
T
P
E
E
--
I
L
A
--------------
R
-
I
----
G
S
---
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
A
L
V
----
L
R
H
P
W
I
----
V
H
--------
W
D
Q
L
P
Q
Y
Q
-----------------------------------------------
607
HHSearch
38.11
33%
-25
- C1 -
-
4B99
1
MK07_HUMAN
A:
[52-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
E
Y
-
E
I
I
E
-
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
---
P
N
A
F
D
V
------
V
T
N
A
K
-
R
T
L
-------
R
---
E
L
K
I
L
K
H
F
-
K
-
H
D
--
N
I
I
A
I
-
K
-
D
I
L
-
R
P
TVPYGEF
K
-
S
-
V
-
Y
-------
V
V
L
D
L
M
E
-
S
D
L
H
Q
I
I
H
--
S
S
-
Q
P
----
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
-
L
V
N
E
---
N
C
-
E
-
L
K
I
G
D
F
G
M
A
-
R
-
G
---
L
------QYF
M
T
-
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
---
L
S
--
L
H
--
E
Y
T
Q
A
-
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
-
P
G
--
K
------
N
Y
V
H
Q
--
L
Q
L
IMMVLGTPSPAVIQ-R
V
RAYI
Q
S
LPP
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
-----
S
A
A
A
A
----
L
R
H
P
F
L
----
A
K
--------
Y
H
-----------------------------------------------------
254
Blastp_CBE
36.93
36%
-24
- C1 -
-
2PZY
1
MAPK2_HUMAN
A:
[18-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
DR----
A
----
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
----------------
T
P
Y
Y
V
A
P
E
V
L
------
G
P
E
--
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
--
H
------
G
L
A
I
S
PG
M
K
T
--------------
R
-
I
----
R
M
---
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
220
Blastp_CBE
36.83
36%
-11
- C1 -
-
3KN5
1
KS6A5_HUMAN
A:
[17-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
---
S
K
R
M
E
A
------------
N
T
Q
-------
K
---
E
I
T
A
L
K
L
C
E
G
-
H
P
--
N
I
V
K
L
-
H
-
E
V
F
H
D
Q
-------
L
-
H
-
T
-
F
-------
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
--
K
K
-
K
H
----
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
-
L
F
T
D
----
L
-
E
-
I
K
I
I
D
F
G
F
A
-
R
-
L
---
K
P
P
--------------------------------
N
--
G
Y
D
E
S
-
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
-
Q
----C-----
T
S
A
V
E
--
I
M
K
--------------
K
-
I
----
K
K
---
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
-----
K
M
S
G
L
----
R
Y
N
E
W
L
----
Q
D
---------------------------------------------------------------
252
Blastp_CBE
36.02
36%
-14
- C1 -
-
2PZY
1
MAPK2_HUMAN
C:
[18-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
DR
G
D
-
Q
A
----
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
----------------
T
P
Y
Y
V
A
P
E
V
L
------
G
P
E
--
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
--
H
------
G
L
A
I
S
PG
M
K
T
--------------
R
-
I
----
R
M
---
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
219
Blastp_CBE
35.98
36%
-4
- C1 -
-
3KN5
1
B:
[17-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
---
S
K
R
M
E
A
------------
N
T
Q
-------
K
---
E
I
T
A
L
K
L
C
E
G
-
H
P
--
N
I
V
K
L
-
H
-
E
V
F
H
D
Q
-------
L
-
H
-
T
-
F
-------
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
--
K
K
-
K
H
----
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
-
L
F
T
D
----
L
-
E
-
I
K
I
I
D
F
G
F
A
-
R
-
L
---
K
P
P
--------------------------------
N
--
G
Y
D
E
S
-
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
-
Q
S
--
H
DRSLTC
T
S
A
V
E
--
I
M
K
--------------
K
-
I
----
K
K
---
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
-----
K
M
S
G
L
----
R
Y
N
E
W
L
----
Q
D
---------------------------------------------------------------
253
Blastp_CBE
34.95
36%
-18
- C1 -
-
2PZY
1
MAPK2_HUMAN
B:
[18-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
DR
G
D
-
Q
A
----
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
----------------
T
P
Y
Y
V
A
P
E
V
L
------
G
P
E
--
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
---------------G-
M
K
T
--------------
R
-
I
----
R
M
---
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
379
Blastp_CBE
33.30
36%
-5
- C1 -
-
1NY3
1
MAPK2_HUMAN
A:
[58-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D-----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
-
T
S
H
-------------
P
Y
Y
V
A
P
E
V
L
------
G
P
E
--
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
---------------G-
M
K
T
--------------
R
-
I
----
R
M
---
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
283
Blastp_CBE
32.71
36%
-17
- C1 -
-
3FYK
1
MAPK2_HUMAN
X:
[14-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
DR
G
D
-
Q
A
----
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
-
T
S
----------------------------------
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------------------------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
285
Blastp_CBE
32.23
36%
-9
- C1 -
-
2P3G
1
MAPK2_HUMAN
X:
[14-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
DR
G
D
-
Q
A
----
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
-
T
S
----------------------------------
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------------------------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
284
Blastp_CBE
31.85
36%
-15
- C1 -
-
3FYJ
1
MAPK2_HUMAN
X:
[14-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
DR
G
D
-
Q
A
----
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
-
T
S
----------------------------------
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------------------------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
185
Blastp_CBE
31.18
36%
-8
- C1 -
-
3R1N
1
MAPK3_HUMAN
A:
[6-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
V
T
D
D
Y
-
Q
L
S
K
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
YDS
P
K
A
R
Q
E
V
D
H
H
W
Q
A
S
G
G
P
-
H
I
V
-------
C
---
I
L
D
V
Y
E
N
M
-
H
-
H
G
KR
C
L
L
--------------------------------
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
ER
G
---
A
----
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
E
K
D
A
-
V
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
-
T
-------------------------------
P
E
--
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
--------------------------------------------------
Y
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
-----
T
I
T
Q
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
287
Blastp_CBE
30.77
36%
14
- C1 -
-
3R30
1
MAPK2_HUMAN
A:
[13-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
-
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D-----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
-
T
-------------------------------
P
E
--
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
---------------G-
M
K
T
--------------
R
-
I
----
R
M
---
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
187
Blastp_CBE
30.59
36%
-8
- C1 -
-
3FHR
1
MAPK3_HUMAN
A:
[25-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
V
T
D
D
Y
-
Q
L
S
K
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
YDS
P
K
A
R
Q
E
V
D
H
H
W
Q
A
S
G
G
P
-
H
I
V
-------
C
---
I
L
D
V
Y
E
N
M
-
H
-
H
G
KR
C
L
L
--------------------------------
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
ER-
D
-
Q
A
----
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
E
K
D
A
-
V
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
----------------------------------
E
--
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
---------------------------------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
-----
T
I
T
Q
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
288
Blastp_CBE
30.32
36%
9
- C1 -
-
3R2Y
1
MAPK2_HUMAN
A:
[13-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D-----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
-
T
-------------------------------------
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y------------------
M
K
T
--------------
R
-
I
----
R
M
---
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
184
Blastp_CBE
30.07
36%
-8
- C1 -
-
3SHE
1
MAPK3_HUMAN
A:
[6-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
V
T
D
D
Y
-
Q
L
S
K
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
YDS
P
K
A
R
Q
E
V
D
H
H
W
Q
A
S
G
G
P
-
H
I
V
-------
C
---
I
L
D
V
Y
E
N
M
-
H
-
H
G
KR
C
L
L
--------------------------------
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E-----
A
----
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
E
K
D
A
-
V
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
----------------------------------
E
--
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
--------------------------------------------------
Y
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
-----
T
I
T
Q
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
442
Blastp_CBE
29.98
35%
-1
- C1 -
-
3KA0
1
MAPK2_HUMAN
A:
[12-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
I
I
D
D
Y
K
V
T
S
Q
-
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------------
Q
D
C
P
K
A
-
R
R
E
-------
V
---
E
L
H
-
W
R
A
S
-
Q
-
C
P
--
H
I
V
R
I
-
V
-
D
V
Y
----------
E
-
N
-
L
-
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D-----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
R
P
N
A
-
I
-
L
K
L
T
D
F
G
F
A
-
K
-
E
---
T
-------------------------------------
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y----------------G-
M
K
T
--------------
R
-
I
----
R
M
---
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
186
Blastp_CBE
29.17
36%
-9
- C1 -
-
3FXW
1
MAPK3_HUMAN
A:
[25-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
V
T
D
D
Y
-
Q
L
S
K
Q
V
L
G
L
G
V
-
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
YDS
P
K
A
R
Q
E
V
D
H
H
W
Q
A
S
G
G
P
-
H
I
V
-------
C
---
I
L
D
V
Y
E
N
M
-
H
-
H
G
KR
C
L
L
--------------------------------
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
ER-
D
-
Q
A
----
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
-
L
Y
T
S
K
E
K
D
A
-
V
-
L
K
L
T
D
F
G
F
A
-
K
-
E
--------------------------------------
E
--
K
Y
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
---------------------------------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
-----
T
I
T
Q
F
----
M
N
H
P
W
I
---------------------------------------------------------------------
160
Blastp_CBE
22.66
41%
-23
- C1 -
-
3I7C
1
?
A:
[26-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
-
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
R
Q
V
K
Q
K
T
D
K
E
S
------
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
-
I
K
L
-
Y
-
E
F
F
-
E
D
-------
K
-
G
-
Y
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
-
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
-
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
E
S
K
S
K
D
A
-
N
-
I
R
I
I
D
F
G
L
S
-
T
-
H
---
F
--
E
A
S
K
---
K
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-------
H
G
--
T
Y
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
--
A
------
N
E
Y
D
I
--
L
K
---------------
K
-
V
----
E
K
---
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
L
T
Y
V
--
P
S
R
I
-----
S
A
R
D
A
----
L
D
H
E
W
I
----
Q
----------------------------------------------------------------