@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CLK1_HUMAN: (2021-11-22 )
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
Atome Classification :
(95 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190..---.....200...--....210.......220..--.....230.......240...--....-250.......260.......270.......280.......290.......300---------........310.......320.......-330.....-.-.340.......350...-....360.......370.......380.......390.......-----400.---......410---..---.--.-----------.---..420.----.--.---....-----430-.---------.----------..-----.---------...-.-440........450........460.......470.......480..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRHSKRTYCPDWDDKDWDYGKWRSSS
S
H
K
R
R
KRSHSSAQENKRCKYN
H
S
KM
C
D
S
H
YLESRSIN
E
K
D
Y
H
S
R
R
Y
I
D
E
Y
R
N
D
Y
TQGCEPGHRQR
D
H
E
S
R
Y
QNHSSKSSGRSG
R
S
SYKSK
H
R
IHHSTSH
R
R
SH
G
K
S
H
R
R
K
RTRSVEDDEE
G
H
L
I
CQSGD
V
L
S
A
R
Y
E
I
V
D
T
LGE
G
A
F
G
K
V
V
E
C
I
DHKAGG
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
HLNTTDPN
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
HHG
H
I
C
I
V
F
E
L
LG--L
S
T
Y
-
D
F
I
K
ENG
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
HSNKLTHTDLKPE
N
I
L
F
V
QSDY----------TEAYNPKIKRDERTLINPD
I
K
V
V
DFGSA-TYDDEH
H
S
-
T
-
L
V
S
TRHYRAP
E
V
I
L
ALG-WSQPC
D
V
W
S
I
G
C
I
L
I
E
Y
Y
LG
F
T
V
FPTHD
S
K
E
H
L
A
M
M
E
R
I
LGPL
P
-----
K
H
M
I
---
Q
K
T
R
K
R
KYF---HH---D--R-----------L---DWDEHS----S--A---
G
R
Y
V
-----
S
---
R
---------
R
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
SQDV
E
H
E
R
L
F
-
D
L
I
Q
K
M
LEYDPAK
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
KSI
37
Blastp_CBE
97.23
99%
-143
- C1 -
-
6G33
1
CLK1_HUMAN
A:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
24
Blastp_CBE
96.84
99%
-145
- C1 -
-
6Q8P
1
CLK1_HUMAN
B:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
---
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
27
Blastp_CBE
96.60
99%
-142
- C1 -
-
6I5K
3
CLK1_HUMAN
C:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
10
PsiBlast_PDB
96.27
99%
-139
- C1 -
-
6I5K
3
CLK1_HUMAN
A:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
11
PsiBlast_PDB
96.12
99%
-141
- C1 -
-
6I5L
3
CLK1_HUMAN
A:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
7
PsiBlast_PDB
96.05
99%
-141
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
28
Blastp_CBE
95.97
99%
-143
- C1 -
-
6I5K
5
CLK1_HUMAN
B:
[3-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
26
Blastp_CBE
95.91
99%
-141
- C1 -
-
6I5L
2
CLK1_HUMAN
B:
[3-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
30
Blastp_CBE
95.90
99%
-140
- C1 -
-
6FT9
2
CLK1_HUMAN
C:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
17
PsiBlast_PDB
95.86
99%
-142
- C1 -
-
2VAG
1
CLK1_HUMAN
A:
[3-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
---
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
23
Blastp_CBE
95.82
99%
-140
- C1 -
-
6Q8P
1
CLK1_HUMAN
C:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
--
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
35
Blastp_CBE
95.54
99%
-137
- C1 -
-
5J1V
1
CLK1_HUMAN
B:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
33
Blastp_CBE
95.47
99%
-137
- C1 -
-
5J1W
3
CLK1_HUMAN
B:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
25
Blastp_CBE
95.28
99%
-141
- C1 -
-
6I5L
4
CLK1_HUMAN
C:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
6
PsiBlast_PDB
95.28
99%
-141
- C1 -
-
6G33
1
CLK1_HUMAN
B:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
5
PsiBlast_PDB
95.21
99%
-134
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
31
Blastp_CBE
94.97
99%
-142
- C1 -
-
6FT9
2
CLK1_HUMAN
B:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
99
HHSearch
94.96
100%
-141
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
29
Blastp_CBE
94.91
99%
-140
- C1 -
-
6G33
1
CLK1_HUMAN
C:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
-
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
13
PsiBlast_PDB
94.91
99%
-139
- C1 -
-
6Q8K
2
CLK1_HUMAN
A:
[3-339]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
I
12
PsiBlast_PDB
94.85
99%
-146
- C1 -
-
6I5H
7
CLK1_HUMAN
A:
[3-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
-----------
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
9
PsiBlast_PDB
94.34
99%
-138
- C1 -
-
6I5I
13
CLK1_HUMAN
A:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
-----------
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
98
HHSearch
94.21
100%
-142
- C1 -
-
6I5L
4
CLK1_HUMAN
C:
[5-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
14
PsiBlast_PDB
93.93
99%
-138
- C1 -
-
6Q8P
1
CLK1_HUMAN
A:
[3-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
94
HHSearch
93.62
100%
-136
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[149-482]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
--
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
22
Blastp_CBE
93.40
99%
-136
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[149-482]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
--
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
100
HHSearch
93.38
100%
-136
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[4-337]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
----
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
--
36
Blastp_CBE
93.10
99%
-137
- C1 -
-
5X8I
1
CLK1_HUMAN
A:
[8-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
15
PsiBlast_PDB
93.07
99%
-139
- C1 -
-
6RAA
2
CLK1_HUMAN
A:
[3-336]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
18
PsiBlast_PDB
92.92
87%
-141
- C1 -
-
6FYV
1
CLK4_HUMAN
A:
[5-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
R
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
G
M
D
G
M
H
V
A
V
K
I
V
K
---
N
V
G
R
Y
R
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
S
T
D
P
N
S
V
F
R
C
--
V
Q
M
L
E
W
F
D
H
H
G
H
V
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
S
F
L
P
F
Q
I
D
H
I
R
Q
M
A
Y
Q
I
C
Q
S
I
N
F
L
H
H
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
K
S
D
Y
----------
V
V
K
Y
N
---
K
R
D
E
R
T
L
K
N
T
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
Q
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
Q
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
N
--
Q
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
R
---
R
---------
R
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
C
H
D
E
E
H
E
K
L
F
-
D
L
V
R
R
M
L
E
Y
D
P
T
Q
R
I
T
L
D
E
A
L
Q
H
P
F
F
D
L
L
K
---
21
Blastp_CBE
92.44
99%
-141
- C1 -
-
6KHD
1
CLK1_HUMAN
C:
[150-479]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
-----
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
-----
16
PsiBlast_PDB
92.18
99%
-138
- C1 -
-
5X8I
1
CLK1_HUMAN
B:
[9-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
95
HHSearch
91.18
100%
-143
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[149-481]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
---------
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
F
---
H
H
---
D
--
R
-----------
L
---
D
W
D
E
H
S
----
S
--
A
---
G
R
Y
V
-----
S
---
R
---------
A
----------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
---
34
Blastp_CBE
90.31
99%
-148
- C1 -
-
5J1V
2
CLK1_HUMAN
C:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
---
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
Y
-------------------------------------------------------------------------------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
39
Blastp_CBE
90.27
66%
-131
- C1 -
-
6FYK
1
CLK2_HUMAN
B:
[5-350]
---------------------------------------------------------------------------------------------------------------------------------------
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
41
Blastp_CBE
90.14
66%
-143
- C1 -
-
5UNP
1
CLK2_HUMAN
A:
[13-356]
-----------------------------------------------------------------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
40
Blastp_CBE
90.13
66%
-142
- C1 -
-
5UNP
1
CLK2_HUMAN
B:
[13-356]
-----------------------------------------------------------------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
38
Blastp_CBE
90.00
66%
-134
- C1 -
-
6FYK
1
CLK2_HUMAN
C:
[5-350]
---------------------------------------------------------------------------------------------------------------------------------------
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
32
Blastp_CBE
89.68
99%
-143
- C1 -
-
5J1W
5
CLK1_HUMAN
C:
[3-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
--
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
--
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
--
L
S
T
Y
-
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
----------
T
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
-
T
Y
D
D
E
H
H
S
-
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
-----
K
H
M
I
---
Q
K
T
R
K
R
K
--------------------------------------------------------------------------------
C
K
-----
P
---------
L
K
E
-
F
-
M
-
L
S
Q
D
V
E
H
E
R
L
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
S
-
43
Blastp_CBE
89.53
67%
-134
- C1 -
-
3NR9
1
CLK2_HUMAN
C:
[15-355]
--------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
45
Blastp_CBE
89.23
67%
-138
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[15-355]
--------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
-------
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
19
PsiBlast_PDB
89.18
66%
-137
- C1 -
-
6FYK
1
CLK2_HUMAN
A:
[5-350]
---------------------------------------------------------------------------------------------------------------------------------------
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
44
Blastp_CBE
88.96
67%
-134
- C1 -
-
3NR9
1
CLK2_HUMAN
B:
[15-354]
--------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
----
56
Blastp_CBE
88.57
62%
-138
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[31-369]
------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
42
Blastp_CBE
87.75
67%
-136
- C1 -
-
6FYI
1
CLK2_HUMAN
A:
[20-355]
-------------------------------------------------------------------------------------------------------------------------------------------------
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
54
Blastp_CBE
87.73
62%
-135
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[31-369]
------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
20
PsiBlast_PDB
87.60
66%
-136
- C1 -
-
6FYL
1
CLK2_HUMAN
A:
[11-350]
---------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
51
Blastp_CBE
87.46
62%
-130
- C1 -
-
6FT7
8
CLK3_HUMAN
B:
[6-348]
--------------------------------------------------------------------------------------------------------------------------------------
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
46
Blastp_CBE
87.39
66%
-139
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[144-483]
---------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---
53
Blastp_CBE
86.68
62%
-133
- C1 -
-
3RAW
1
CLK3_HUMAN
B:
[33-369]
--------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
48
Blastp_CBE
86.53
61%
-132
- C1 -
-
6FYP
1
CLK3_HUMAN
A:
[11-348]
-------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
47
Blastp_CBE
86.19
61%
-133
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[4-348]
------------------------------------------------------------------------------------------------------------------------------------
S
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
49
Blastp_CBE
86.00
62%
-130
- C1 -
-
6RCT
7
CLK3_HUMAN
B:
[10-348]
------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
55
Blastp_CBE
85.93
62%
-134
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[32-369]
-------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
52
Blastp_CBE
85.78
62%
-132
- C1 -
-
6FT7
7
CLK3_HUMAN
A:
[6-348]
--------------------------------------------------------------------------------------------------------------------------------------
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
50
Blastp_CBE
85.74
62%
-132
- C1 -
-
6RCT
8
CLK3_HUMAN
A:
[11-348]
-------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
-------
96
HHSearch
85.17
55%
-139
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[144-484]
---------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
--
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
--
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
--
L
S
T
F
-
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
----------
E
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
K
S
T
A
V
R
V
V
D
F
G
S
A
-
T
F
D
H
E
H
H
S
-
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
-
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
-----
S
R
M
I
---
R
K
T
R
K
Q
K
Y
F
---
Y
R
---
G
--
R
-----------
L
---
D
W
D
E
N
T
----
S
--
A
---
G
R
Y
V
-----
R
---
E
---------
N
----------
C
K
-----
P
---------
L
R
R
-
Y
-
L
-
T
S
E
A
E
E
H
H
Q
L
F
-
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
--
102
HHSearch
85.09
61%
-134
- C1 -
-
6FT7
7
CLK3_HUMAN
B:
[16-352]
------------------------------------------------------------------------------------------------------------------------------------------------
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
---
101
HHSearch
85.01
61%
-136
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[15-352]
-----------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
----------
E
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
---
97
HHSearch
83.05
61%
-146
* C1 *
-
6KHF
1
CLK3_HUMAN
A:
[142-477]
--------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
V
C
R
I
G
D
W
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
-----------------------
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
--
58
Blastp_CBE
82.61
61%
-147
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[142-475]
--------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
V
C
R
I
G
D
W
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
--
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
--
K
N
T
F
-
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
-----------------------
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
-
T
F
D
H
E
H
H
T
-
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
-----
S
H
M
I
---
H
R
T
R
K
Q
K
Y
F
---
Y
K
---
G
--
G
-----------
L
---
V
W
D
E
N
S
----
S
--
D
---
G
R
Y
V
-----
K
---
E
---------
N
----------
C
K
-----
P
---------
L
K
S
-
Y
-
M
-
L
Q
D
S
L
E
H
V
Q
L
F
-
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
----
107
HHSearch
67.07
35%
-103
- C1 -
-
5Y86
8
DYRK3_HUMAN
A:
[200-525]
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
H
-
K
L
R
Q
Y
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
M
N
V
--
I
H
M
L
E
S
F
T
F
R
N
H
V
C
M
A
F
E
L
L
S
--
I
D
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
H
K
N
K
I
I
H
C
D
L
K
P
E
N
I
L
L
K
H
H
G
---------------------------
R
S
S
T
K
V
I
D
F
G
S
S
-
C
F
E
Y
Q
K
L
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
S
R
-
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
P
G
E
D
E
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
-----
P
K
L
L
---
E
Q
S
K
R
A
K
Y
F
---
I
N
---
S
--
K
-----------
G
IP-
R
Y
C
S
V
T
TQAD
G
--
R
---
V
V
L
V
-----
G
---
G
---------
R
----------
S
R
-----
R
GKKRGPPG-
S
K
D
-
W
-
G
T
A
L
K
G
C
D
D
Y
L
F
I
-
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
P
W
I
S
K
S
----
61
Blastp_CBE
66.46
36%
-100
- C1 -
-
5LXD
6
DYRK2_HUMAN
A:
[60-391]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
---
V
S
---
S
--
K
GYPRYCTVTTL
S
---
D
G
S
V
V
L
----
N
--
G
---
G
R
-------
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
104
HHSearch
66.40
36%
-117
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[94-416]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
---
V
S
---
S
KG
Y
-----------
P
---
R
Y
C
T
V
T
----
T
--
L
SDG
S
V
V
L
-----
N
---
G
GRSRRGKLR
G
----------
P
P
-----
E
---------
S
R
E
-
W
G
N
-
A
L
K
G
C
D
D
P
L
F
L
-
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
---
60
Blastp_CBE
66.38
36%
-100
- C1 -
-
5LXD
6
DYRK2_HUMAN
B:
[60-391]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
---
V
S
---
S
--
K
GYPRYCTVTTL
S
---
D
G
S
V
V
L
----
N
--
G
---
G
R
-------
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
62
Blastp_CBE
66.10
36%
-98
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[60-391]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
---
V
S
---
S
--
K
GYPRYCTVTTL
S
---
D
G
S
V
V
L
----
N
--
G
---
G
R
-------
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
105
HHSearch
65.63
37%
-109
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[72-394]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
---
V
S
---
S
KG
Y
-----------
P
---
R
Y
C
T
V
T
----
T
--
L
SD-
G
S
V
V
-----
L
---
N
---------
G
GRSRRGKLRG
P
P
-----
E
---------
S
R
E
-
W
G
N
-
A
L
K
G
C
D
D
P
L
F
L
-
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
----
63
Blastp_CBE
65.53
36%
-98
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[60-391]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
---
V
S
---
S
--
K
GYPRYCTVTTL
S
---
D
G
S
V
V
L
----
N
--
G
---
G
R
-------
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
59
Blastp_CBE
64.96
36%
-53
- C1 -
-
3LLT
1
?
A:
[20-360]
-----------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
-
Q
H
I
D
N
K
K
Y
Y
A
V
K
V
V
R
---
N
I
K
K
Y
T
R
S
A
K
I
--
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
N
N
-
N
I
--
V
K
Y
H
G
K
F
M
Y
Y
D
H
M
C
L
I
F
E
P
L
G
--
P
S
L
Y
-
E
I
I
T
R
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
Y
F
EKSLITVRRV
T
D
G
K
K
I
Q
I
Y
R
T
K
S
T
----
G
I
K
L
I
D
F
G
C
A
-
T
F
K
S
D
Y
H
G
-
S
-
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
G
-
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
-----
K
N
M
L
YEA
T
K
T
N
G
S
K
Y
V
---
N
K
---
D
EL
K
-----------
L
---
A
W
P
E
N
A
----
S
--
S
---
I
N
S
I
-----
K
HV-
K
---------
K
----------
C
L
-----
P
---------
L
Y
K
-
I
-------
I
K
H
E
L
F
C
-
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
------
109
HHSearch
64.35
37%
-112
- C1 -
-
6K0J
1
?
A:
[5-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
---
N
N
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
A
K
P
E
N
I
L
L
K
Q
Q
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
---
V
S
---
S
KG
Y
-----------
P
RYC
T
V
T
T
L
S
----
D
--
G
---
S
V
V
L
-----
N
---
G
---------
G
----------
R
S
-----
R
RGKLRGPPE
S
R
E
W
G
-
N
-
A
L
K
G
C
D
D
P
L
F
L
-
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
A
-----
66
Blastp_CBE
63.75
36%
-105
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[81-412]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
VSK
G
Y
---
P
--
R
-----------
Y
---
C
T
V
T
T
L
----
S
--
D
---
G
S
V
V
LNGGR
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
70
Blastp_CBE
63.67
36%
-105
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[81-412]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
VSK
G
Y
---
P
--
R
-----------
Y
---
C
T
V
T
T
L
----
S
--
D
---
G
--
V
LNGGR
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
103
HHSearch
63.56
37%
-104
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[94-413]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
---------------------------
R
S
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
---
V
S
SK-
G
--
Y
-----------
P
---
R
Y
C
T
V
T
----
T
LS
D
----
V
V
L
-----
N
GGR
S
RRGKLR---
G
----------
P
P
-----
E
---------
S
R
E
-
W
G
N
-
A
L
K
G
C
D
D
P
L
F
L
-
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
------
65
Blastp_CBE
63.29
36%
-106
- C1 -
-
3KVW
1
DYRK2_HUMAN
A:
[81-412]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
VSK
G
Y
---
P
--
R
-----------
Y
---
C
T
V
T
T
L
----
S
--
D
---
G
--
V
LNGGR
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
64
Blastp_CBE
63.11
36%
-106
- C1 -
-
6HDR
2
DYRK2_HUMAN
A:
[81-412]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
VSK
G
Y
---
P
--
R
-----------
Y
---
C
T
V
T
T
L
----
S
--
D
---
G
--
V
LNGGR
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
67
Blastp_CBE
61.30
36%
-106
- C1 -
-
5ZTN
1
DYRK2_HUMAN
B:
[81-412]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
VSK
G
Y
---
P
--
R
-----------
Y
---
C
T
V
T
T
----------------LNGGR
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
68
Blastp_CBE
61.01
36%
-106
- C1 -
-
5ZTN
1
DYRK2_HUMAN
A:
[81-412]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
VSK
G
Y
---
P
--
R
-----------
Y
---
C
T
V
T
T
----------------LNGGR
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
71
Blastp_CBE
59.33
36%
-112
- C1 -
-
6K0J
1
?
A:
[5-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
---
N
N
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
--
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
--
M
N
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
A
K
P
E
N
I
L
L
K
Q
Q
G
R
----------
S
-----------------
G
I
K
V
I
D
F
G
S
S
-
C
Y
E
H
Q
R
V
Y
-
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
-
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
-----
Q
K
L
L
---
D
A
S
K
R
A
K
N
F
VSK
G
Y
---
P
--
R
-----------
Y
---
C
T
V
T
T
L
----
S
--
D
---
G
S
V
V
LNGGR
S
---
R
---------
R
----------
G
K
LRGPP
E
---------
S
R
E
-
W
-
G
-
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-------
72
Blastp_CBE
52.39
36%
-61
- C1 -
-
5Y86
7
DYRK3_HUMAN
A:
[191-522]
----------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
H
K
L
R
-
Q
Y
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
--
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
M
N
V
--
I
H
M
L
E
S
F
T
F
R
N
H
V
C
M
A
F
E
L
L
S
--
I
D
L
Y
-
E
L
I
K
K
N
K
F
Q
G
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
H
K
N
K
I
I
H
C
D
L
K
P
E
N
I
L
-----------------------
L
K
H
H
G
R
S
-----
T
K
V
I
D
F
G
S
S
-
C
F
E
Y
Q
K
L
Y
-
T
--
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
S
R
-
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
P
G
E
D
E
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
-----
P
K
L
L
---
E
Q
S
K
R
A
K
Y
F
---
I
N
KGI
P
--
R
-----------
Y
---
C
S
V
T
T
Q
----
A
--
D
---
G
R
V
V
LVGGR
S
---
R
---------
R
----------
G
K
KRGPP
G
---------
S
K
D
-
W
-
G
-
T
A
L
K
G
C
D
D
Y
L
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
P
-
A
Q
A
L
R
H
P
W
I
-------
79
Blastp_CBE
47.53
32%
-39
- C1 -
-
2B9I
1
FUS3_YEAST
A:
[9-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
-
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
---
P
F
D
K
P
L
F
A
L
R
T
LR
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
---
I
Q
R
P
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
--
T
D
L
H
-
R
V
I
S
T
Q
M
L
---
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
-----------------------------
N
C
D
L
K
V
C
D
F
G
L
A
-
R
I
I
D
E
---V
E
-
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-
T
P
HSDND
L
R
C
I
---
E
S
P
R
A
R
E
Y
I
--------------------------------
K
----
S
--
L
---
P
M
Y
P
-----
A
-------------------------
A
-----
P
---------
L
E
K
-
M
-
F
-
P
R
V
N
---
P
K
G
I
-
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------
78
Blastp_CBE
46.29
32%
-38
- C1 -
-
2B9J
1
FUS3_YEAST
A:
[9-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
-
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
---
P
F
D
K
P
L
F
A
L
R
T
LR
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
---
I
Q
R
P
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
--
T
D
L
H
-
R
V
I
S
T
Q
M
L
---
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
-----------------------------
N
C
D
L
K
V
C
D
F
G
L
A
-
R
I
I
D
----V
E
-
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-
T
P
HSDND
L
R
C
I
---
E
S
P
R
A
R
E
Y
I
--------------------------------
K
----
S
--
L
---
P
M
Y
P
-----
A
-------------------------
A
-----
P
---------
L
E
K
-
M
-
F
-
P
R
V
N
---
P
K
G
I
-
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------
80
Blastp_CBE
46.04
32%
-43
- C1 -
-
2B9H
1
FUS3_YEAST
A:
[9-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
-
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
---
P
F
D
K
P
L
F
A
L
R
T
LR
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
---
I
Q
R
P
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
--
T
D
L
H
-
R
V
I
S
T
Q
M
L
---
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
-----------------------------
N
C
D
L
K
V
C
D
F
G
L
A
-
R
I
I
D
----V
E
-
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-
T
P
HSDND
L
R
C
I
---
E
S
P
R
A
R
E
Y
I
--------------------------------
K
----
S
--
L
---
P
M
Y
P
-----
A
-------------------------
A
-----
P
---------
L
E
K
-
M
-
F
-
P
R
V
N
---
P
K
G
I
-
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------
81
Blastp_CBE
45.79
32%
-37
- C1 -
-
2B9F
1
FUS3_YEAST
A:
[9-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
-
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
---
P
F
D
K
P
L
F
A
L
R
T
LR
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
---
I
Q
R
P
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
--
T
D
L
H
-
R
V
I
S
T
Q
M
L
---
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
-----------------------------
N
C
D
L
K
V
C
D
F
G
L
A
-
R
I
I
D
---
T
-
E
-
Y
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-
T
P
HSDND
L
R
C
I
---
E
S
P
R
A
R
E
Y
I
--------------------------------
K
----
S
--
L
---
P
M
Y
P
-----
A
-------------------------
A
-----
P
---------
L
E
K
-
M
-
F
-
P
R
V
N
---
P
K
G
I
-
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------
73
Blastp_CBE
45.62
32%
-43
- C1 -
-
2F9G
1
FUS3_YEAST
A:
[9-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
-
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
---
P
F
D
K
P
L
F
A
L
R
T
LR
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
---
I
Q
R
P
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
--
T
D
L
H
-
R
V
I
S
T
Q
M
L
---
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
-----------------------------
N
C
D
L
K
V
C
D
F
G
L
A
-
R
I
I
D
----------
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-
T
P
HSDND
L
R
C
I
---
E
S
P
R
A
R
E
Y
I
--------------------------------
K
----
S
--
L
---
P
M
Y
P
-----
A
-------------------------
A
-----
P
---------
L
E
K
-
M
-
F
-
P
R
V
N
---
P
K
G
I
-
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
-------
86
Blastp_CBE
43.34
32%
-32
- C1 -
-
1XO2
1
CDK6_HUMAN
B:
[12-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
VQT
G
E
E
G
M
P
L
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
T
V
S
---
R
E
T
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
-
V
P
--
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
-
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
R
D
V
----
A
--
L
---
P
R
Q
A
FH----------------------------
A
Q
-----
P
---------
I
E
K
-
F
-
V
-
T
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
--
90
Blastp_CBE
42.92
32%
-45
- C1 -
-
4EZ5
1
CDK6_HUMAN
A:
[12-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
---------
P
L
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
--------
T
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
V
---
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
A
--------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
R
D
V
----
A
--
L
---
P
R
Q
A
FH-----------------
S
----------
A
Q
-----
P
---------
I
E
K
-
F
-
V
-
T
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
-------
92
Blastp_CBE
42.02
32%
-44
- C1 -
-
3NUX
1
CDK6_HUMAN
A:
[12-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
--------
P
L
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
--------
T
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
V
---
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
A
--------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
R
D
V
----
A
--
L
---
P
R
Q
A
FH-------
K
---------
S
----------
A
Q
-----
P
---------
I
E
K
-
F
-
V
-
T
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
-------
85
Blastp_CBE
41.12
32%
-25
- C1 -
-
2EUF
2
CDK6_HUMAN
B:
[12-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
VQT
G
E
E
G
M
P
L
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
T
V
S
R
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
-
V
P
--
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
-
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
------------------------------------------------
A
Q
-----
P
---------
I
E
K
-
F
-
V
-
T
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
--
91
Blastp_CBE
40.76
32%
-38
- C1 -
-
4AUA
1
CDK6_HUMAN
A:
[12-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
------------
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
--------
T
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
V
---
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
A
---------------
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
R
D
V
----
A
--
L
---
P
R
Q
A
FH---
S
---
K
---------
S
----------
A
Q
-----
P
---------
I
E
K
-
F
-
V
-
T
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
-------
84
Blastp_CBE
39.83
32%
-29
- C1 -
-
2F2C
2
CDK6_HUMAN
B:
[12-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
-
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
VQT
G
E
E
G
M
P
L
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
T
V
S
-
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
-
V
P
--
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
-
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
----------------
Q
A
F-----------------------------
A
Q
-----
P
---------
I
E
K
-
F
-
V
-
T
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
R
--
87
Blastp_CBE
39.43
32%
-19
- C1 -
-
5L2T
1
CDK6_HUMAN
A:
[12-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V---------
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
--------
T
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
V
---
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
A
--------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
R
D
V
----
A
--
L
---
P
R
Q
A
FH---
S
---
K
---------
S
----------
A
Q
-----
P
---------
I
E
K
-
F
-
V
-
T
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
-------
88
Blastp_CBE
39.24
32%
-23
- C1 -
-
5L2S
1
CDK6_HUMAN
A:
[12-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V-------
P
L
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
--------
T
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
V
---
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
A
--------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
R
D
V
----
A
--
L
---
P
R
Q
A
FH---
S
---
K
---------
S
----------
A
Q
-----
P
---------
I
E
K
-
F
-
V
-
T
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
-------
93
Blastp_CBE
38.70
32%
-53
- C1 -
-
3NUP
1
CDK6_HUMAN
A:
[12-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
----------
L
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
T
V
-------
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
V
---
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
---------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
R
D
V
----
A
--
L
---
P
R
Q
A
FH-----------------
S
----------
A
Q
-----
P
---------
I
E
K
-
F
-
V
-
T
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
-------
89
Blastp_CBE
37.65
32%
-38
- C1 -
-
5L2I
1
CDK6_HUMAN
A:
[12-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
--------
P
L
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
--------
T
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
V
---
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
---------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
R
D
V
----
A
--
L
---
P
R
Q
A
F--------
K
---------
S
----------
A
Q
-----
P
---------
I
E
K
-
F
-
V
-
T
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
-------
82
Blastp_CBE
35.11
31%
-11
- C1 -
-
4TTH
1
CDK6_HUMAN
B:
[15-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
A
E
I
G
E
----
K
V
F
K
A
R
D
L
K
N
-
G
R
F
V
A
L
K
R
V
R
V----
E
G
M
P
L
S
T
I
R
--
E
V
A
V
L
R
H
L
E
T
F
E
H
P
N
V
V
R
L
FD
V
C
T
-------
T
K
L
T
L
V
F
E
H
V
D
QD
L
T
T
Y
L
D
K
V
P
E
P
G
V
---
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
S
G
-----------------------------
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
L
-
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
-
L
P
-----
G
E
E
----------------------------------------
D
W
P
-------------------------------------------------------
P
---------
I
E
K
-
F
----
D
I
D
---
E
L
G
K
-
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
E
---