@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CLK3_HUMAN: (2021-11-22 )
MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR
Atome Classification :
(107 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400-.......410.......420.--......430.......440...-....450.......-----460.......470.......480.......490.......500.......510.......520.......530.......540.....---.-.550-.-..-.-.-.--.----560-..---.-..--.--.----.-.--570.---------.---------.--------.---------..--------..580---------------.-.---------....--------------------.590.---.......600.......610.......620.--......630......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPV
L
S
A
R
R
R
E
L
A
D
HAGSGRRSGPSPTARSGPH
L
S
A
L
RAQPA
R
A
AHLSGR
G
T
Y
V
R
RDTAGGGPGQARPLGPP
G
T
S
L
L
GRGARRSGEGWCPGAFESGARAARPPSRVE
P
R
L
ATAASREGAGLP
R
A
E
VAAGSGRGARSGEWGLAAA
G
A
W
E
T
M
H
H
C
K
RYRSPEPDP
Y
L
S
Y
R
W
K
R
RRSYSREHEGRLRYPSRREPPPRRSRSRSHDRL
P
Y
Q
R
R
Y
R
E
RRDSDT
Y
R
CEERSPSFGEDYYGP
S
R
S
R
H
R
R
RSRERGPYR
T
R
K
H
A
H
H
C
H
K
R
R
TRSCSSASSR
S
Q
Q
SSKRSSRSVEDDKE
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
VGNLGE
G
T
F
G
K
V
V
E
C
L
D
H
ARG
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
KDKEN
K
F
L
C
V
L
M
S
D
W
F
N
FHG
H
M
C
I
A
F
E
L
LG
K
N
T
F
E
F
L
K
ENNFQP-YPL
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--ENQLTHTDLKPE
N
I
L
F
VN
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
KSV-----KNT
S
I
R
V
A
DFGSATFDHEH
H
T
T
I
V
A
TRHYR
P
P
E
V
I
LELGWAQPC
D
V
W
S
I
G
C
I
L
F
E
Y
YRG
F
T
L
F
Q
THEN
R
E
H
L
V
M
M
E
K
I
LGPI
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-Y-K-G--
G
----
L
---
V
W---D-EN--S--S----D-G--R-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
LEFDPA
Q
R
I
T
L
A
E
A
L
L
H
P
F
FAGL--TP
E
E
RSFHTSRNPSR
2
PsiBlast_PDB
96.41
99%
-131
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[31-380]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
-------
4
PsiBlast_PDB
95.72
99%
-125
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[31-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
T
------
10
PsiBlast_PDB
95.51
100%
-129
- C1 -
-
2EU9
1
CLK3_HUMAN
A:
[1-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
-
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
---------
5
PsiBlast_PDB
95.47
99%
-124
- C1 -
-
6FT7
7
CLK3_HUMAN
A:
[5-360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
T
------
8
PsiBlast_PDB
95.36
100%
-126
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[4-358]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
--------
23
Blastp_CBE
95.11
99%
-122
- C1 -
-
6FT7
8
CLK3_HUMAN
B:
[5-360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
T
------
3
PsiBlast_PDB
94.86
99%
-128
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[32-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
--------
7
PsiBlast_PDB
94.71
100%
-126
- C1 -
-
6FYP
1
CLK3_HUMAN
A:
[11-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
--------
6
PsiBlast_PDB
94.33
99%
-122
- C1 -
-
6RCT
8
CLK3_HUMAN
A:
[11-360]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
T
------
21
Blastp_CBE
94.28
99%
-123
- C1 -
-
3RAW
1
CLK3_HUMAN
B:
[33-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
T
------
22
Blastp_CBE
94.02
99%
-120
- C1 -
-
6RCT
7
CLK3_HUMAN
B:
[10-360]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
T
------
138
HHSearch
93.45
100%
-127
- C1 -
-
6FT7
7
CLK3_HUMAN
B:
[15-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
H
T
------
139
HHSearch
93.05
100%
-133
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[17-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
-
T
L
Y
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
F
--------
134
HHSearch
93.02
100%
-142
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[142-481]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
V
C
R
I
G
D
W
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
--------------
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
---------
1
PsiBlast_PDB
92.82
99%
-142
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[142-481]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
V
C
R
I
G
D
W
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
-
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
--------------
S
V
-----
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
---
R
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
K
-
G
--
G
----
L
---
V
W
---
D
-
E
N
--
S
--
S
----
D
-
G
--
R
-
Y
V
---------
K
---------
E
--------
N
---------
C
K
--------
P
L
K
S
Y
---------------
M
-
L
---------
Q
D
S
L
--------------------
E
H
V
-
Q
---
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
---------
25
Blastp_CBE
89.79
72%
-129
- C1 -
-
6FYK
1
CLK2_HUMAN
B:
[4-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
--
R
A
E
------------
26
Blastp_CBE
89.48
72%
-141
- C1 -
-
5UNP
1
CLK2_HUMAN
B:
[13-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
--
R
--------------
14
PsiBlast_PDB
88.98
71%
-141
- C1 -
-
5UNP
1
CLK2_HUMAN
A:
[13-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
--
R
--------------
24
Blastp_CBE
88.96
72%
-133
- C1 -
-
6FYK
1
CLK2_HUMAN
C:
[4-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
--
R
A
E
------------
12
PsiBlast_PDB
88.81
71%
-134
- C1 -
-
6FYK
1
CLK2_HUMAN
A:
[4-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
--
R
A
E
------------
27
Blastp_CBE
88.17
72%
-134
- C1 -
-
3NR9
1
CLK2_HUMAN
C:
[15-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
--
R
--------------
15
PsiBlast_PDB
88.03
72%
-138
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[15-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
-------
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
--
R
A
-------------
13
PsiBlast_PDB
87.57
71%
-135
- C1 -
-
6FYL
1
CLK2_HUMAN
A:
[11-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
--
R
--------------
28
Blastp_CBE
87.47
72%
-131
- C1 -
-
3NR9
1
CLK2_HUMAN
B:
[15-354]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
-----------------
135
HHSearch
86.63
72%
-144
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[149-485]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
--
R
A
E
------------
11
PsiBlast_PDB
86.62
70%
-139
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[144-485]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
RA
E
--------------
16
PsiBlast_PDB
85.28
72%
-137
- C1 -
-
6FYI
1
CLK2_HUMAN
A:
[20-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
Y
H
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
-
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
D
Y
E
-
L
T
Y
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
---
K
-
T
R
K
Q
-
K
-
Y
F
-
Y
-
R
-
G
--
R
----
L
---
D
W
---
D
-
E
N
--
T
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
E
--------
N
---------
C
K
--------
P
L
R
R
Y
---------------
L
-
T
---------
S
E
A
E
--------------------
E
H
H
-
Q
---
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
--
R
--------------
35
Blastp_CBE
85.12
61%
-136
- C1 -
-
6Q8K
2
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
45
Blastp_CBE
84.69
61%
-137
- C1 -
-
6G33
1
CLK1_HUMAN
B:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
43
Blastp_CBE
84.49
61%
-144
- C1 -
-
6I5H
6
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
------------
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
39
Blastp_CBE
84.32
61%
-138
- C1 -
-
6I5K
3
CLK1_HUMAN
C:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
33
Blastp_CBE
84.25
61%
-140
- C1 -
-
6Q8P
1
CLK1_HUMAN
B:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
---
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
40
Blastp_CBE
84.05
61%
-140
- C1 -
-
6I5K
5
CLK1_HUMAN
B:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
31
Blastp_CBE
84.03
61%
-137
- C1 -
-
6RAA
2
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
36
Blastp_CBE
84.00
61%
-137
- C1 -
-
6I5L
4
CLK1_HUMAN
C:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
47
Blastp_CBE
83.88
61%
-139
- C1 -
-
6FT9
2
CLK1_HUMAN
B:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
18
PsiBlast_PDB
83.66
63%
-138
- C1 -
-
6FYV
1
CLK4_HUMAN
A:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
R
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
G
M
D
G
M
H
V
A
V
K
I
V
K
N
V
G
R
Y
R
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
S
T
D
P
N
S
V
F
R
C
V
Q
M
L
E
W
F
D
H
H
G
H
V
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
S
F
L
P
-
F
Q
I
D
H
I
R
Q
M
A
Y
Q
I
C
Q
S
I
N
F
L
H
--
H
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
K
S
D
Y
V
-
V
K
Y
N
---
K
R
D
E
R
T
L
-----
K
N
T
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
Q
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
I
P
Q
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
N
--
Q
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
R
---------
R
--------
R
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
C
H
D
E
--------------------
E
H
E
-
K
---
L
F
D
L
V
R
R
M
L
E
Y
D
P
T
Q
R
I
T
L
D
E
A
L
Q
H
P
F
F
D
L
L
-----------------
37
Blastp_CBE
83.61
61%
-137
- C1 -
-
6I5L
2
CLK1_HUMAN
B:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
41
Blastp_CBE
83.58
61%
-135
- C1 -
-
6I5K
3
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
49
Blastp_CBE
83.56
61%
-137
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
20
PsiBlast_PDB
83.49
61%
-133
- C1 -
-
5J1V
2
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
58
Blastp_CBE
83.32
61%
-137
- C1 -
-
6G33
1
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
32
Blastp_CBE
83.26
61%
-139
- C1 -
-
6Q8P
1
CLK1_HUMAN
C:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
--
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
48
Blastp_CBE
83.25
61%
-134
- C1 -
-
6FT9
4
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
38
Blastp_CBE
83.17
61%
-135
- C1 -
-
6I5L
3
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
51
Blastp_CBE
83.15
61%
-134
- C1 -
-
5J1W
3
CLK1_HUMAN
B:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
56
Blastp_CBE
83.11
61%
-137
- C1 -
-
5X8I
1
CLK1_HUMAN
B:
[9-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
46
Blastp_CBE
83.11
61%
-135
- C1 -
-
6FT9
2
CLK1_HUMAN
C:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
136
HHSearch
83.07
61%
-137
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[149-481]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
---------
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
--
K
--------------
54
Blastp_CBE
83.06
61%
-134
- C1 -
-
5J1V
1
CLK1_HUMAN
B:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
19
PsiBlast_PDB
82.91
61%
-133
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
----
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
44
Blastp_CBE
82.69
61%
-136
- C1 -
-
6G33
1
CLK1_HUMAN
C:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
-
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
52
Blastp_CBE
82.58
61%
-132
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
140
HHSearch
82.52
61%
-135
- C1 -
-
6I5L
4
CLK1_HUMAN
C:
[8-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
--
K
--------------
42
Blastp_CBE
82.29
61%
-135
- C1 -
-
6I5I
13
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
--------
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
59
Blastp_CBE
82.18
61%
-137
- C1 -
-
2VAG
1
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
---
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
34
Blastp_CBE
82.18
61%
-133
- C1 -
-
6Q8P
1
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
142
HHSearch
82.05
61%
-134
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[9-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
--
K
--------------
141
HHSearch
82.01
61%
-131
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[8-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
----
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
--
K
--------------
57
Blastp_CBE
81.89
61%
-135
- C1 -
-
5X8I
1
CLK1_HUMAN
A:
[8-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
137
HHSearch
81.66
61%
-132
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[149-481]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
--
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
--
K
--------------
55
Blastp_CBE
80.93
61%
-131
- C1 -
-
6FYO
1
CLK1_HUMAN
A:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
---
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
R
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
17
PsiBlast_PDB
80.59
49%
-137
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[149-480]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
---------
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
29
Blastp_CBE
79.60
50%
-138
- C1 -
-
6KHD
1
CLK1_HUMAN
C:
[150-479]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
-----
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
------------------
30
Blastp_CBE
79.32
50%
-132
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[149-480]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
--
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
F
-
H
-
H
-
D
--
R
----
L
---
D
W
---
D
-
E
H
--
S
--
S
----
A
-
G
--
R
-
Y
V
---------
S
---------
R
--------
A
---------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
53
Blastp_CBE
78.34
61%
-144
- C1 -
-
5J1V
2
CLK1_HUMAN
C:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
---
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
-
Y
------------------------------------------------------------------------------------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
50
Blastp_CBE
76.78
61%
-139
- C1 -
-
5J1W
5
CLK1_HUMAN
C:
[3-335]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
-
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
-
E
A
Y
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
---
K
-
T
R
K
R
-
K
--------------------------------------------------------------------------------------
C
K
--------
P
L
K
E
F
---------------
M
-
L
---------
S
Q
D
V
--------------------
E
H
E
-
R
---
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
-----------------
143
HHSearch
69.45
35%
-113
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[72-394]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
V
S
-
S
-
K
G-
Y
----
P
---
R
Y
---
C
-
T
V
TT
L
--
S
----
D
-
G
--
S
-
V
V
LNGGRSR--
R
GKL------
R
--------
G
---------
P
P
--------
E
S
R
E
W
---------------
G
N
A
---------
L
K
G
C
--------------------
D
D
P
-
L
---
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
-----------------
148
HHSearch
69.27
35%
-108
- C1 -
-
5Y86
8
DYRK3_HUMAN
A:
[202-526]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
H
K
L
R
-
Q
Y
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
M
N
V
I
H
M
L
E
S
F
T
F
R
N
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
H
--
K
N
K
I
I
H
C
D
L
K
P
E
N
I
L
L
K
H
H
-----------------------
G
R
S
S
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
L
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
S
R
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
P
G
E
D
E
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
L
L
E
---
Q
-
S
K
R
A
-
K
-
Y
F
I
N
-
S
-
K
--
G
I---
P
---
R
Y
---
C
-
S
V
--
T
TQ
A
----
D
-
G
RV
V
-
L
V
---------
G
---------
G
RSRRGKKR
G
---------
P
P
--------
G
S
K
D
W
---------------
G
T
A
---------
L
K
G
C
--------------------
D
D
Y
-
L
---
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
P
W
I
S
K
S
--
V
--------------
145
HHSearch
68.62
34%
-117
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[93-418]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
N
F
V
-
S
-
S
-
K
G-
Y
----
P
---
R
Y
---
C
-
T
V
--
T
TL
S
----
D
G
S
--
V
-
V
L
NGGRSRRGK
L
---------
R
--------
G
---------
P
P
--------
E
S
R
E
W
---------------
G
-
N
A--------
L
K
G
C
--------------------
D
D
P
-
L
---
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
--
L
P
K
------------
144
HHSearch
68.23
35%
-122
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[93-413]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
N
F
V
-
S
S
K
-
G
--
Y
----
P
---
R
Y
---
C
-
T
V
TT
L
--
S
----
D
-----V
V
L
---------
N
GGRSRRGKL
R
--------
G
---------
P
P
--------
E
S
R
E
W
---------------
G
N
A
---------
L
K
G
C
--------------------
D
D
P
-
L
---
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------
149
HHSearch
67.62
34%
-116
- C1 -
-
6K0J
1
?
A:
[5-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
N
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
A
K
P
E
N
I
L
L
K
Q
Q
-----------------------
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
N
F
V
-
S
S
K
-
G
--
Y
----
P
---
R
Y
CTV
T
-
T
L
--
S
--
D
----
G
-
S
--
V
-
V
L
---------
N
---------
G
--------
G
RSRRGKLRG
P
P
--------
E
S
R
E
W
---------------
G
N
A
---------
L
K
G
C
--------------------
D
D
P
-
L
---
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
A
A
-----------------
60
Blastp_CBE
63.72
38%
-65
- C1 -
-
3LLT
1
?
A:
[20-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
-
Q
H
I
D
N
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
N
N
N
I
-
V
K
Y
H
G
K
F
M
Y
Y
D
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
Y
N
G
-
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
--
K
M
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
Y
F
E
K
S
L
I
T
V
R
R
V
T
D
G
K
K
I
QIYRT
K
S
T
G
I
K
L
I
D
F
G
C
A
T
F
K
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
EAT
K
-
T
N
G
S
-
K
-
Y
V
-
N
-
K
-
D
EL
K
----
L
---
A
W
---
P
-
E
N
--
A
--
S
----
S
-
I
--
N
-
S
I
---------
K
---------
H
--------
V
---------
K
K
--------
C
L
P
L
Y
---------------
K
-
I
------------
I
--------------------
K
H
E
-
L
---
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
--------------------
152
HHSearch
62.64
33%
-79
* C1 *
-
6S1H
4
DYR1A_HUMAN
A:
[22-355]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
Q
-
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
R
K
-
F
F
-
E
-
K
L
P
--
D
----
G
---
T
W
---
N
-
L
K
--
K
--------------
Y
K
---------
P
---------
P
--------
G
---------
T
R
--------
K
L
H
N
I
LGVETGGPGGRRAGE
S
-
G
---------
H
T
V
A
--------------------
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
67
Blastp_CBE
58.81
33%
-76
- C1 -
-
5LXD
6
DYRK2_HUMAN
B:
[60-391]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
S
--
K
GYPR
Y
---
C
T
---
V
-
T
T
--
L
--
S
----
D
-
G
--
S
-
V
V
---------
L
---------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
69
Blastp_CBE
58.51
33%
-73
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[60-391]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
S
--
K
GYPR
Y
---
C
T
---
V
-
T
T
--
L
--
S
----
D
-
G
--
S
-
V
V
---------
L
---------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
85
Blastp_CBE
58.04
31%
-90
- C1 -
-
6S17
8
DYR1A_HUMAN
A:
[24-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
--
T
------------------------------------------------------
Y
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
86
Blastp_CBE
57.93
31%
-84
- C1 -
-
6S14
1
DYR1A_HUMAN
A:
[24-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
--
T
-------------------------------------------------------
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
61
Blastp_CBE
57.93
34%
-75
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[81-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
K
--
G
YPR-
Y
---
C
T
---
V
-
T
T
--
L
--
S
----
D
-
G
--
S
-
V
V
---------
L
---------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
70
Blastp_CBE
57.89
33%
-73
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[60-391]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
S
--
K
GYPR
Y
---
C
T
---
V
-
T
T
--
L
--
S
----
D
-
G
--
S
-
V
V
---------
L
---------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
68
Blastp_CBE
57.46
33%
-75
- C1 -
-
5LXD
6
DYRK2_HUMAN
A:
[60-391]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
S
--
K
GYPR
Y
---
C
T
---
V
-
T
T
--
L
--
S
----
D
-
G
--
S
-
V
V
---------
L
---------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
64
Blastp_CBE
57.46
34%
-77
- C1 -
-
6HDR
2
DYRK2_HUMAN
A:
[81-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
K
--
G
YPR-
Y
---
C
T
---
V
-
T
T
--
L
--
S
----
D
-
G
--
S
------------
L
---------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
88
Blastp_CBE
57.43
31%
-78
- C1 -
-
6S11
1
DYR1A_HUMAN
A:
[24-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
--
T
--
K
--------------------------------
R
--------
E
---------
Y
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
78
Blastp_CBE
57.39
31%
-82
- C1 -
-
6S1J
8
DYR1A_HUMAN
A:
[24-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
--
T
-------------------------------------------------------
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
65
Blastp_CBE
57.21
34%
-75
- C1 -
-
3KVW
1
DYRK2_HUMAN
A:
[81-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
K
--
G
YPR-
Y
---
C
T
---
V
-
T
T
--
L
--
S
----
D
-
G
--
S
------------
L
---------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
66
Blastp_CBE
57.17
34%
-77
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[81-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
K
--
G
YPR-
Y
---
C
T
---
V
-
T
T
--
L
--
S
----
D
-
G
--
S
------------
L
---------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
109
Blastp_CBE
57.10
31%
-80
- C1 -
-
6A1F
2
DYR1A_HUMAN
A:
[25-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
--
T
--
K
----
D
----------------------------------------------
Y
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
94
Blastp_CBE
56.97
31%
-89
- C1 -
-
4YLK
13
DYR1A_HUMAN
A:
[24-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
--
T
------------------------------------------------------
Y
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
93
Blastp_CBE
56.76
31%
-89
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[24-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
--
T
------------------------------------------------------
Y
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
107
Blastp_CBE
56.19
31%
-78
- C1 -
-
6A1G
1
DYR1A_HUMAN
B:
[25-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
----------------------------------------------------------
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
62
Blastp_CBE
56.19
34%
-74
- C1 -
-
5ZTN
1
DYRK2_HUMAN
B:
[81-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
K
--
G
YPR-
Y
---
C
T
---
V
-
T
T
--
L
-----------------------------------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
108
Blastp_CBE
56.12
31%
-82
- C1 -
-
6A1G
1
DYR1A_HUMAN
A:
[25-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
-------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
---------------------------------------------------------
Y
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
63
Blastp_CBE
55.97
34%
-75
- C1 -
-
5ZTN
1
DYRK2_HUMAN
A:
[81-412]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
K
--
G
YPR-
Y
---
C
T
---
V
-
T
T
--
L
-----------------------------------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
73
Blastp_CBE
55.89
32%
-65
- C1 -
-
5Y86
8
DYRK3_HUMAN
A:
[191-527]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
H
-
K
L
R
Q
Y
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
M
N
V
I
H
M
L
E
S
F
T
F
R
N
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
H
--
K
N
K
I
I
H
C
D
L
K
P
E
N
I
L
L
K
H
------------------------
H
G
R
S
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
L
Y
T
I
Y
Q
S
R
F
Y
R
A
P
E
I
I
L
G
S
R
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
P
G
E
D
E
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
L
L
E
---
Q
-
S
K
R
A
-
K
-
Y
F
-
I
-
N
-
K
--
G
----
I
PRY
C
S
---
V
-
T
T
--
Q
--
A
----
D
-
G
--
R
-
V
V
---------
L
---------
V
--------
G
---------
G
R
SRRGKKRG
P
P
G
S
K
---------------
D
-
W
---------
G
T
A
L
--------------------
K
G
C
-
D
DYL
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
P
-
A
Q
A
L
R
H
P
W
I
S
K
S
--
V
P
-------------
72
Blastp_CBE
55.38
33%
-80
- C1 -
-
6K0J
1
?
A:
[5-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
N
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
-
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
R
I
I
H
C
D
A
K
P
E
N
I
L
L
------------------
K
Q
Q
-----
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
---
A
-
S
K
R
A
-
K
-
N
F
-
V
-
S
-
K
--
G
YPR-
Y
---
C
T
---
V
-
T
T
--
L
--
S
----
D
-
G
--
S
-
V
V
---------
L
---------
N
--------
G
---------
G
R
SRRGKLRG
P
P
E
S
R
---------------
E
-
W
---------
G
N
A
L
--------------------
K
G
C
-
D
DPL
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
84
Blastp_CBE
54.71
31%
-78
- C1 -
-
6S1B
2
DYR1A_HUMAN
A:
[24-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
L------
G
---
T
W
---
N
L
K
K
--
T
-------------------------------------------------------
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
114
Blastp_CBE
54.43
31%
-77
- C1 -
-
2WO6
1
DYR1A_HUMAN
B:
[45-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
--------------------------------------
R
--------
E
---------
Y
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
120
Blastp_CBE
53.84
32%
-35
- C1 -
-
6PK6
1
A:
[16-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
----------
N
E
S
K
--------------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
---
K
G
V
F
K
D
-
Q
-
H
F
-
D
-
Q
-
N
L-
N
----
F
---
M
Y
---
I
-
E
V
--
D
--
K
VTER
E
-
K
--
V
-
T
V
---------
M
---------
S
--------
T
---------
I
N
--------
P
T
K
D
L
---------------
L
-
A
DLIGCQRLP
E
D
Q
R
--------------------
K
K
V
H
Q
---
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
--------------------
87
Blastp_CBE
52.81
31%
-79
- C1 -
-
6S11
1
DYR1A_HUMAN
B:
[24-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
--
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
----------------------------------------------------------
Y
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVTGGPGGRESGHTVA----
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
124
Blastp_CBE
51.68
32%
-35
- C1 -
-
4IIR
1
PRP4B_HUMAN
A:
[15-348]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
----------
N
E
S
K
--------------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
---
K
G
V
F
K
D
-
Q
-
H
F
-
D
-
Q
-
N
L-
N
----
F
---
M
Y
---
I
-
E
-------R---
E
-
K
--
V
-
T
V
---------
M
---------
S
--------
T
---------
I
N
--------
P
T
K
D
L
---------------
L
-
A
DLIGP----
E
D
Q
R
--------------------
K
K
V
H
Q
---
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
--------------------
126
Blastp_CBE
50.38
32%
-36
- C1 -
-
4IFC
1
PRP4B_HUMAN
A:
[15-348]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
----------
N
E
S
K
--------------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
---
K
G
V
F
K
D
-
Q
-
H
F
-
D
-
Q
-
N
L-
N
----
F
---
M
Y
---
I
-
E
-------R---
E
-
K
--
V
-
T
V
---------
M
---------
S
--------
T
---------
I
N
--------
P
T
K
D
L
---------------
L
-
A
DLIGP----
E
D
Q
R
--------------------
K
K
V
H
Q
---
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
--------------------
122
Blastp_CBE
50.25
32%
-26
- C1 -
-
4IJP
1
PRP4B_HUMAN
A:
[15-348]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
----------
N
E
S
K
--------------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
---
K
G
V
F
K
D
-
Q
-
H
F
-
D
-
Q
-
N
L-
N
----
F
---
M
Y
---
I
-
E
V
--
D
--
K
R---
E
-
K
--
V
-
T
V
---------
M
---------
S
--------
T
---------
I
N
--------
P
T
K
D
L
---------------
L
-
A
DLIGRLP--
E
D
Q
R
--------------------
K
K
V
H
Q
---
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
--------------------
121
Blastp_CBE
49.76
32%
-27
- C1 -
-
4IJP
1
B:
[15-348]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
----------
N
E
S
K
--------------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
---
K
G
V
F
K
D
-
Q
-
H
F
-
D
-
Q
-
N
L-
N
----
F
---
M
Y
---
I
-
E
V
--
D
--
K
----
E
-
K
--
V
-
T
V
---------
M
---------
S
--------
T
---------
I
N
--------
P
T
K
D
L
---------------
L
-
A
DLIGCQRLP
E
D
Q
R
--------------------
K
K
V
H
Q
---
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
--------------------
123
Blastp_CBE
49.51
32%
-27
- C1 -
-
4IIR
1
B:
[15-348]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
---
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
----------
N
E
S
K
--------------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
---
K
G
V
F
K
D
-
Q
-
H
F
-
D
-
Q
-
N
L-
N
----
F
---
M
Y
---
I
-
E
V
--
D
--
K
R---
E
-
K
--
V
-
T
V
---------
M
---------
S
--------
T
---------
I
N
--------
P
T
K
D
L
---------------
L
-
A
DLIGRLP--
E
D
Q
R
--------------------
K
K
V
H
Q
---
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
--------------------
125
Blastp_CBE
49.09
32%
-31
- C1 -
-
4IFC
1
B:
[15-348]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
-
V
F
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
----------
N
E
S
K
--------------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
---
K
G
V
F
K
D
-
Q
-
H
F
-
D
-
Q
-
N
L-
N
----
F
---
M
Y
---
I
-
E
V
--
D
--
K
R---
E
-
K
--
V
-
T
V
---------
M
---------
S
--------
T
---------
I
N
--------
P
T
K
D
L
---------------
L
-
A
DLIGRLP--
E
D
Q
R
--------------------
K
K
V
H
Q
---
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
--------------------
83
Blastp_CBE
41.12
31%
-82
- C1 -
-
6S1H
4
DYR1A_HUMAN
A:
[24-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
V
E
-
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
-
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
Y
Q
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
---
Q
-
A
P
K
A
-
R
-
K
F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
--
T
-------------------------------------------------------
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
115
Blastp_CBE
39.89
31%
-77
- C1 -
-
2WO6
1
DYR1A_HUMAN
A:
[45-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
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F
G
Q
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K
A
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D
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-
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I
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A
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A
Q
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L
L
E
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H
D
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Y
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I
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H
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M
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R
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H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
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G
-
V
S
L
N
L
T
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K
F
A
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Q
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C
T
A
L
L
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L
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
-----------------------
K
R
S
A
I
K
I
V
D
F
G
S
S
C
-
Q
L
G
Q
R
I
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L
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M
P
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A
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D
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C
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A
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D
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M
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K
I
V
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V
L
G
I
P
P
A
H
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L
D
---
Q
-
A
P
K
A
-
R
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F
-
F
-
E
-
K
LP
D
----
G
---
T
W
---
N
L
K
K
--
T
--
K
-----------------------------------------
E
---------
Y
K
--------
P
P
G
T
R
---------------
K
-
L
---------
H
N
I
L
GVETGGPGGRRAGESGHTVA
D
Y
L
-
K
---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------