@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CSF1R_HUMAN: (2021-11-22 )
MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC
Atome Classification :
(472 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500......---.510.......520.......530.......540.......550..--.....560.....--..570-.----------......580.......590....----------...600..--.-..--.--.610.........620........630.......640.......650..-.-....660.......670.....-..680....---...690.......700.......710.......720.......730.......740-.........-----750----........760.......770.......780.....---.---.790.......800.......810.......820.......830.......840.......850.......860..-------.....870.......880.......890.......900.....----..910.......920.......930.......940.......950.......960.......970
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGPG
V
L
L
L
L
L
V
A
T
AWHGQGIPVIEPSVP
E
L
V
VKPG
A
T
V
T
L
R
C
VGNGSVEWDGPPSP
H
W
T
L
YSDGSS
S
I
LSTNNATFQNTG
T
Y
RCTEPGDPLGG
S
A
A
I
H
L
Y
VKDPAR
P
W
N
V
L
A
Q
E
V
V
V
FEDQDAL
L
P
C
LLT
D
P
V
L
E
A
G
V
S
L
V
RVRGRPLMRHTNYSFSPWH
G
F
T
I
H
R
A
K
F
IQSQDYQ
C
S
A
LMGG
R
K
V
M
S
I
S
I
R
L
K
V
Q
KVIPGPP
A
L
T
L
V
P
A
E
L
V
R
IRGE
A
A
Q
I
V
C
SAS
S
V
D
V
N
F
D
V
F
L
Q
HNN
T
K
L
AIPQQSDFHNN
R
Y
Q
K
V
L
T
L
NLD
Q
V
D
F
QHAGNY
S
C
V
ASNVQGKH
S
T
S
M
F
F
R
V
V
E
S
A
Y
LNLS
S
E
Q
N
L
I
Q
E
VTVGEGL
N
L
K
V
M
V
E
AYPGLQGF
N
W
T
Y
LGPFSDHQPEPKLANATTKD
T
Y
R
H
T
F
T
LSLPRLKPSEAG
R
Y
S
F
L
ARNPGG
W
R
A
L
T
F
E
L
T
L
RYPP
E
V
S
V
I
W
T
F
INGS
G
T
L
L
C
AASGYPQPN
V
T
W
L
Q
CSGHTDRCD
E
A
Q
V
L
Q
VWDDP
Y
P
E
V
LSQEP
F
H
K
V
T
V
Q
S
L
L
T
V
E
TLEHNQ
T
Y
E
C
R
AHNSVGSG
S
W
A
F
I
P
ISAGAHTH---P
P
D
E
F
L
F
T
P
V
V
V
A
C
M
S
I
M
A
L
L
L
L
L
L
L
L
L
L
Y
K
YKQKP
K
Y
Q
V
R
W
K
I
I
E
--SYEGN
S
Y
T
F
IDPT--QLPYN-E----------KWEFPRNNLQFGKTLGA
G
A
F
G
K
V
----------
V
E
A
T
AFGL--G-K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T-AHA
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
LGQ
H
E
N
I
V
N
L
L
G
ACT-H-G
G
P
V
L
V
I
TEYC
C
Y
G
D
L
L
N
F
L
R
R
-
K
A
E
A
MLGPS---LSPGQDPEGGVDY
K
N
I
H
L
E
K
K
Y
V
RRDSGFSSQGV
D
T
Y
V
E
M
RPVSTSSNDSFSEQ---DLDKEDGR
P
-----
L
-
E
----
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
ASKN
C
I
H
R
D
VAAR
N
V
L
LT---N---G
H
V
A
KIG
D
F
G
L
A
R
D
I
MNDS
N
Y
I
V
KGN
A
R
L
P
V
K
WM
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
LGLNPYP
G
I
L
V
N
S
K
-------
F
Y
K
L
V
KDGYQMAQPAFA
P
K
N
I
Y
S
I
M
Q
A
C
WALEPTHR
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
D
R
R
ERDYTNLPSSSRSGGSGSS
S
S
E
L
EEESSSE
H
L
T
CCEQGDIAQPLLQPNNYQFC
1
PsiBlast_PDB
84.79
100%
-111
* C8 *
-
4LIQ
1
?
E:
[22-502]
-------------------
I
P
V
I
E
P
S
V
P
E
L
V
V
K
P
G
A
T
V
T
L
R
C
V
G
N
G
S
V
E
W
D
G
P
P
S
P
H
W
T
L
Y
S
D
G
S
S
S
I
L
S
T
N
N
A
T
F
Q
N
T
G
T
Y
R
C
T
E
P
G
-----
S
A
A
I
H
L
Y
V
K
D
P
A
R
P
W
N
V
L
A
Q
E
V
V
V
F
E
D
Q
D
A
L
L
P
C
L
L
T
D
P
V
L
E
A
G
V
S
L
V
R
V
---
P
L
M
R
H
T
N
Y
S
F
S
P
W
H
G
F
T
I
H
R
A
K
F
I
Q
S
Q
D
Y
Q
C
S
A
L
M
G
G
R
K
V
M
S
I
S
I
R
L
K
V
Q
K
V
I
P
G
P
P
A
L
T
L
V
P
A
E
L
V
R
I
R
G
E
A
A
Q
I
V
C
S
A
S
S
V
D
V
N
F
D
V
F
L
Q
H
N
N
T
K
L
A
I
P
Q
Q
S
D
F
H
N
N
R
Y
Q
K
V
L
T
L
N
L
D
Q
V
D
F
Q
H
A
G
N
Y
S
C
V
A
S
N
V
Q
G
K
H
S
T
S
M
F
F
R
V
V
E
S
A
Y
L
N
L
S
S
E
Q
N
L
I
Q
E
V
T
V
G
E
G
L
N
L
K
V
M
V
E
A
Y
P
G
L
Q
G
F
N
W
T
Y
L
G
P
F
S
D
H
Q
P
E
-
K
L
A
N
A
T
---
T
Y
R
H
T
F
T
L
S
L
P
R
L
K
P
S
E
A
G
R
Y
S
F
L
A
R
N
P
G
G
W
R
A
L
T
F
E
L
T
L
R
Y
P
P
E
V
S
V
I
W
T
F
I
N
G
S
G
T
L
L
C
A
A
S
G
Y
P
Q
P
N
V
T
W
L
Q
C
S
G
H
T
D
R
C
D
E
A
Q
V
L
Q
V
W
D
D
P
Y
P
E
V
L
S
Q
E
P
F
H
K
V
T
V
Q
S
L
L
T
V
E
T
L
E
H
N
Q
T
Y
E
C
R
A
H
N
S
V
G
S
G
S
W
A
F
I
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
HHSearch
83.75
100%
-109
- C8 -
-
4LIQ
1
?
E:
[22-499]
-------------------
I
P
V
I
E
P
S
V
P
E
L
V
V
K
P
G
A
T
V
T
L
R
C
V
G
N
G
S
V
E
W
D
G
P
P
S
P
H
W
T
L
Y
S
D
G
S
S
S
I
L
S
T
N
N
A
T
F
Q
N
T
G
T
Y
R
C
T
E
P
G
-----
S
A
A
I
H
L
Y
V
K
D
P
A
R
P
W
N
V
L
A
Q
E
V
V
V
F
E
D
Q
D
A
L
L
P
C
L
L
T
D
P
V
L
E
A
G
V
S
L
V
R
V
---
P
L
M
R
H
T
N
Y
S
F
S
P
W
H
G
F
T
I
H
R
A
K
F
I
Q
S
Q
D
Y
Q
C
S
A
L
M
G
G
R
K
V
M
S
I
S
I
R
L
K
V
Q
K
V
I
P
G
P
P
A
L
T
L
V
P
A
E
L
V
R
I
R
G
E
A
A
Q
I
V
C
S
A
S
S
V
D
V
N
F
D
V
F
L
Q
H
N
N
T
K
L
A
I
P
Q
Q
S
D
F
H
N
N
R
Y
Q
K
V
L
T
L
N
L
D
Q
V
D
F
Q
H
A
G
N
Y
S
C
V
A
S
N
V
Q
G
K
H
S
T
S
M
F
F
R
V
V
E
S
A
Y
L
N
L
S
S
E
Q
N
L
I
Q
E
V
T
V
G
E
G
L
N
L
K
V
M
V
E
A
Y
P
G
L
Q
G
F
N
W
T
Y
L
G
P
F
S
D
H
Q
P
E
-
K
L
A
N
A
T
---
T
Y
R
H
T
F
T
L
S
L
P
R
L
K
P
S
E
A
G
R
Y
S
F
L
A
R
N
P
G
G
W
R
A
L
T
F
E
L
T
L
R
Y
P
P
E
V
S
V
I
W
T
F
I
N
G
S
G
T
L
L
C
A
A
S
G
Y
P
Q
P
N
V
T
W
L
Q
C
S
G
H
T
D
R
C
D
E
A
Q
V
L
Q
V
W
D
D
P
Y
P
E
V
L
S
Q
E
P
F
H
K
V
T
V
Q
S
L
L
T
V
E
T
L
E
H
N
Q
T
Y
E
C
R
A
H
N
S
V
G
S
G
S
W
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
72.83
87%
-134
- C7 -
-
4R7H
1
A:
[14-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Y
Q
V
R
W
K
I
I
E
-------
S
Y
T
F
I
D
P
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
-
K
A
E
A
M
L
G
P
S
---
L
--------------------------------------------------------------
G
R
P
-----
L
-
E
----
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
----
S
F
L
Q
E
Q
A
Q
---------------------------------------------------------
8
PsiBlast_PDB
72.67
87%
-142
- C7 -
-
6IG8
2
?
A:
[1-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
I
I
E
---------
T
F
I
D
P
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
A
E
A
M
L
G
P
S
---
L
--------------------------------------------------------------
G
R
P
-----
L
-
E
----
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
--------------------------------------------------------
21
Blastp_CBE
71.79
88%
-132
- C7 -
-
6T2W
1
?
A:
[6-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
R
W
K
I
I
E
--
S
Y
--
N
S
Y
T
F
I
D
P
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
A
E
A
M
L
----------------------------------------------------------------------
R
P
-----
L
-
E
----
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
--------------------------------------------------------
15
PsiBlast_PDB
71.36
81%
-129
- C7 -
-
2I1M
1
A:
[13-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
R
W
K
I
I
E
--
S
Y
--
N
S
Y
T
F
I
D
P
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
S
R
V
L
---------------------------------------------
E
T
D
-------
S
T
A
S
T
--------------------------
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
D
R
R
E
R
---------------------------------------------------
14
PsiBlast_PDB
71.29
81%
-128
- C7 -
-
3BEA
1
A:
[13-332]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
R
W
K
I
I
E
--
S
Y
E
G
N
S
Y
T
F
I
D
P
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
S
R
V
L
-------------------------------------------------------
S
T
L
S
T
--------------------------
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
D
R
R
E
R
---------------------------------------------------
12
PsiBlast_PDB
71.09
82%
-131
- C7 -
-
3KRJ
1
A:
[10-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Y
Q
V
R
W
K
I
I
E
--
S
Y
E
G
N
S
Y
T
F
I
D
P
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
P
P
G
------------------------------------------------------------
Q
-----------------
L
-
S
----
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
----------------------------------------------------------
6
PsiBlast_PDB
71.06
87%
-134
- C7 -
-
6N33
1
A:
[36-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
-
K
A
E
A
M
L
G
P
S
---
L
S
-------------------------------------------------------------
G
R
P
-----
L
-
E
----
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
----
S
F
L
Q
E
Q
A
Q
---------------------------------------------------------
5
PsiBlast_PDB
70.79
87%
-140
- C7 -
-
4R7I
1
?
A:
[37-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
-
K
A
E
A
M
L
G
P
S
---
L
S
-------------------------------------------------------------
G
R
P
-----
L
-
E
----
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
----
S
F
L
Q
E
Q
A
----------------------------------------------------------
9
PsiBlast_PDB
70.52
82%
-131
- C7 -
-
2I0V
1
A:
[10-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Y
Q
V
R
W
K
I
I
E
--
S
Y
E
G
N
S
Y
T
F
I
D
P
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
--------------------------------------------------------
3
PsiBlast_PDB
69.82
87%
-138
- C7 -
-
4HW7
1
A:
[36-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
-
K
A
E
A
M
L
G
P
S
------------------------------------------------------------------
G
R
P
-----
L
-
E
----
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
----
S
F
L
Q
E
Q
A
----------------------------------------------------------
10
PsiBlast_PDB
69.54
82%
-143
- C7 -
-
2I0Y
1
?
A:
[14-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
--
S
Y
E
--
S
Y
T
F
I
-----------
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
--------------------------------------------------------
7
PsiBlast_PDB
69.09
87%
-133
- C7 -
-
3LCO
1
A:
[2-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
E
----------
F
I
D
P
T
--
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
A
E
A
M
L
G
P
S
------------------------------------------------------------------
G
R
P
-----
L
-
E
----
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
----
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
---------------------------------------------------------
13
PsiBlast_PDB
68.85
82%
-147
- C7 -
-
3KRL
1
A:
[11-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Q
V
R
W
K
I
I
--------------------
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
-
K
E
--
D
--
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
-
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
------------------------------------------------------------
20
PsiBlast_PDB
68.73
60%
-120
- C7 -
-
4HVS
1
A:
[10-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
Y
E
V
Q
W
K
V
V
E
--
E
S
N
G
N
N
Y
S
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Q
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
-----------------------------------
R
D
S
F
H
S
S
-------
D
T
S
P
A
S
M
---------------
E
D
D
E
N
A
-----
L
-
D
----
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
----
Q
D
I
E
K
Q
I
S
E
--------------------------------------------------------
11
PsiBlast_PDB
66.99
82%
-146
- C7 -
-
3DPK
1
A:
[14-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
--
S
----
S
Y
T
F
I
D
------
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
F
G
L
--
G
--------
A
V
--
L
K
V
A
V
K
M
L
K
S
T
-
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
------------------------------------------------------------------
Q
-----------------
L
-
S
----
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
---
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
----
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
-------
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
------------------------------------------------------------
28
Blastp_CBE
66.80
59%
-134
- C7 -
-
6GQL
1
KIT_HUMAN
A:
[22-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Q
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
D
E
F
V
P
Y
--------------------------------------------------------------
L
Y
K
D
---
F
-----
L
-
T
----
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
----
Q
D
I
E
K
Q
I
S
E
--------------------------------------------------------
30
Blastp_CBE
66.78
59%
-131
- C7 -
-
6GQK
1
?
A:
[21-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
S
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Q
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
D
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
---
F
-----
L
-
T
----
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
----
Q
D
I
E
K
Q
I
S
E
--------------------------------------------------------
26
Blastp_CBE
66.62
59%
-134
- C7 -
-
6GQM
2
A:
[23-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Q
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
D
E
F
V
P
Y
--------------------------------------------------------------
L
Y
K
D
---
F
-----
L
-
T
----
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
----
Q
D
I
E
K
Q
I
S
E
--------------------------------------------------------
36
Blastp_CBE
63.71
53%
-159
- C7 -
-
6JQR
5
?
A:
[17-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
Y
F
Y
V
D
F
R
--
E
Y
E
Y
D
-
L
----------
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
----------
M
N
A
T
A
Y
G
I
--
S
--------
V
S
--
I
Q
V
A
V
K
M
L
K
E
---
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
-
K
R
E
K
F
-------------
S
---------------------------------------------------------
N
V
-----
L
-
T
----
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
---
G
K
V
V
K
I
C
D
F
------
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
V
N
P
Y
P
G
I
P
V
D
A
N
-------
F
Y
K
L
I
Q
N
G
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
----
S
F
L
--------------------------------------------------------------
286
Blastp_CBE
62.87
43%
-160
- C7 -
-
6IUO
1
?
A:
[23-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
R
A
E
A
F
G
M
--
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
----------------------------------------
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
37
Blastp_CBE
62.59
55%
-148
- C7 -
-
4XUF
1
B:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
----------
M
N
A
T
A
Y
G
I
--
S
-
K
T
--
G
--
V
S
--
I
Q
V
A
V
K
M
L
K
E
K
-
A
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
-
K
R
--------------------------------------------------------------------------
N
V
-----
L
-
T
----
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
---
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
V
N
P
Y
P
G
I
P
V
D
A
N
-------
F
Y
K
L
I
Q
N
G
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
----
S
F
L
--------------------------------------------------------------
211
Blastp_CBE
62.56
43%
-136
- C7 -
-
4J97
1
B:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
---
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
--------
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
------------------------------------------------------
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
282
Blastp_CBE
62.33
43%
-156
- C7 -
-
4QQC
1
A:
[24-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
R
A
E
A
F
G
M
--------
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
----------------------------------------
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
210
Blastp_CBE
61.94
43%
-136
- C7 -
-
4J97
1
?
C:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
---
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
--------
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
-------------------------------------------------------
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
283
Blastp_CBE
61.43
43%
-154
- C7 -
-
4R6V
1
A:
[24-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
R
A
E
A
F
G
M
--------
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
----------------------------------------
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
38
Blastp_CBE
61.22
55%
-149
- C7 -
-
4XUF
1
FLT3_HUMAN
A:
[3-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
----------
M
N
A
T
A
Y
G
I
--
S
-
K
T
--
G
--
V
S
--
I
Q
V
A
V
K
M
L
K
E
----
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
-
K
R
---------------------------------------------------------------------------------
L
-
T
----
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
---
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
V
N
P
Y
P
G
I
P
V
D
A
N
-------
F
Y
K
L
I
Q
N
G
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
----
S
F
L
--------------------------------------------------------------
284
Blastp_CBE
60.93
43%
-154
- C7 -
-
4QQ5
1
A:
[24-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
R
A
E
A
F
G
M
--------
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
----------------------------------------
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
118
Blastp_CBE
59.83
44%
-159
- C7 -
-
6C1B
1
B:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
-------------
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
565
HHSearch
58.99
46%
-132
- C7 -
-
5FM3
1
A:
[58-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-
S
----------------------------------------------------------------------------
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
P
E
-
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
---------------------------------------------------------
39
Blastp_CBE
58.33
51%
-103
- C7 -
-
3G0E
1
?
A:
[4-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
Y
L
Q
K
P
M
Y
E
V
Q
W
K
V
V
E
--
E
I
N
G
N
N
Y
V
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
H
M
---------
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
I
C
S
K
T
S
P
A
I
M
E
D
D
E
L
A
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
152
Blastp_CBE
58.31
44%
-147
- C7 -
-
4NKS
1
FGFR1_HUMAN
A:
[9-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
----------
V
L
A
E
A
I
----------
N
--
R
V
--
T
K
V
A
V
K
M
L
K
-
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
-------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
309
Blastp_CBE
58.00
37%
-119
- C7 -
-
2IVU
3
A:
[7-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
L
-
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
-------------------------------------
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
-------------------------------------------------------
305
Blastp_CBE
57.79
37%
-132
- C7 -
-
2X2M
4
B:
[7-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
----
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
----
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
---------------------------------------
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
--------------------------------------------------------
301
Blastp_CBE
57.47
38%
-117
- C7 -
-
2IVS
5
RET_HUMAN
A:
[14-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
-----------
K
V
G
P
G
Y
L
-------------------
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
-------------------------------------------------------
304
Blastp_CBE
57.08
37%
-119
- C7 -
-
4CKJ
16
A:
[7-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
L
E
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
-----------
K
V
------------------------
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------
299
Blastp_CBE
57.05
38%
-111
- C7 -
-
6NEC
3
RET_HUMAN
A:
[14-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
-----------
K
V
G
P
G
Y
L
G
----------------
D
E
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
-------------------------------------------------------
126
Blastp_CBE
57.04
44%
-156
- C7 -
-
5UQ0
1
B:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
G
L
-----------
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
--
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
42
Blastp_CBE
57.00
51%
-112
- C7 -
-
6KLA
1
?
A:
[8-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
W
K
V
V
E
--
E
I
N
G
N
N
Y
V
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
---------
H
M
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
-----------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
306
Blastp_CBE
56.72
37%
-124
- C7 -
-
2X2M
3
RET_HUMAN
A:
[7-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
L
-
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
--
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
--------------------------------------
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------
340
Blastp_CBE
56.69
34%
-135
- C7 -
-
6PL3
1
A:
[23-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
--
L
-
P
E
--
Q
--
D
K
--
M
L
V
A
V
K
A
L
K
E
--
S
E
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
----
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
310
Blastp_CBE
56.67
37%
-117
- C7 -
-
2IVT
3
A:
[7-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
----
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
-----------
K
V
------------------------
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
-------------------------------------------------------
307
Blastp_CBE
56.45
37%
-122
- C7 -
-
2X2L
5
A:
[7-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
L
---
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
-----------
K
V
------------------------
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
---------------------------------------------------------
52
Blastp_CBE
56.41
51%
-108
- C7 -
-
6MOB
1
KIT_HUMAN
A:
[2-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
V
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
---------
H
M
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
I
C
S
K
T
S
P
A
I
M
E
D
D
E
L
A
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
303
Blastp_CBE
56.38
37%
-121
- C7 -
-
2IVV
3
A:
[7-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
---------------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
--------------------------------------------
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
S
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
--------------------------------------------------------
298
Blastp_CBE
56.18
38%
-116
- C7 -
-
6NEC
1
C:
[7-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
L
E
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
-----------
K
V
-----------------------
E
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
---------
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
-------------------------------------------------------
300
Blastp_CBE
56.17
38%
-121
- C7 -
-
2IVS
3
B:
[7-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
----
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
-----------
K
-------------------------
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
-----------
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
-------------------------------------------------------
308
Blastp_CBE
56.11
37%
-118
- C7 -
-
2X2K
4
A:
[7-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
----
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
--------------------------------------
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
-----------
K
V
------------------------
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------
334
Blastp_CBE
55.86
31%
-118
- C7 -
-
3LW0
3
IGF1R_HUMAN
A:
[8-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----------
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
----------
Y
E
G
V
A
K
G
V
--
V
-
K
D
--
E
--
P
E
--
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
--------------------------------------
K
S
Y
L
R
--------------
S
L
R
P
-----------------------
P
-----
P
-
S
----
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
-------
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
----
S
S
I
K
E
E
M
E
P
G
F
R
E
----------------------------------------------------
332
Blastp_CBE
55.61
31%
-117
- C7 -
-
3LW0
4
IGF1R_HUMAN
C:
[8-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----------
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
----------
Y
E
G
V
A
K
G
V
--
V
-
K
D
--
E
--
P
E
--
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
--------------------------------------
K
S
Y
L
R
--------------
S
L
R
P
-----------------------
P
-----
P
-
S
----
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
-------
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
----
S
S
I
K
E
E
M
E
P
G
F
R
E
----------------------------------------------------
333
Blastp_CBE
55.58
31%
-117
- C7 -
-
3LW0
4
IGF1R_HUMAN
B:
[8-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----------
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
----------
Y
E
G
V
A
K
G
V
--
V
-
K
D
--
E
--
P
E
--
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
--------------------------------------
K
S
Y
L
R
--------------
S
L
R
P
-----------------------
P
-----
P
-
S
----
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
-------
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
----
S
S
I
K
E
E
M
E
P
G
F
R
E
----------------------------------------------------
331
Blastp_CBE
55.39
31%
-116
- C7 -
-
3LW0
3
D:
[8-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----------
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
----------
Y
E
G
V
A
K
G
V
--
V
-
K
D
--
E
--
P
E
--
T
R
V
A
I
K
T
V
N
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
--------------------------------------
K
S
Y
L
R
--------------
S
L
R
P
-----------------------
P
-----
P
-
S
----
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
-------
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
----
S
S
I
K
E
E
M
E
P
G
F
R
E
----------------------------------------------------
47
Blastp_CBE
55.24
51%
-111
- C7 -
-
6ITV
1
?
A:
[23-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Y
-------------------
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
---------
H
M
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
-----------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
55
Blastp_CBE
55.17
51%
-105
- C7 -
-
6HH1
1
?
A:
[1-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
N
Y
V
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
H
M
---------
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
------
F
L
R
R
---------------------
K
R
D
S
F
I
C
S
---
K
T
S
P
A
I
E
L
A
-----
L
-
D
----
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
-----------------------------------------------------------
35
Blastp_CBE
55.04
49%
-96
- C7 -
-
4RT7
1
A:
[56-407]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
L
----------
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
----------
M
N
A
T
A
Y
G
I
--
S
-----
G
--
V
S
--
I
Q
V
A
V
K
M
L
K
----
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
-
K
R
------------------------------------------------------------------------------------NVLT
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
---
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
V
N
P
Y
P
G
I
P
V
D
A
N
-------
F
Y
K
L
I
Q
N
G
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
----
S
F
L
G
C
Q
L
A
-
D
A
------------------------------------------------------
51
Blastp_CBE
54.88
51%
-104
- C7 -
-
1T46
1
?
A:
[1-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
N
Y
V
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
---------
H
M
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
--------------
L
A
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
316
Blastp_CBE
54.86
35%
-126
- C7 -
-
3L8P
1
A:
[7-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
I
Y
P
V
L
-
D
-----------
W
----
N
D
I
K
F
Q
D
V
I
G
E
G
N
F
G
Q
V
----------
L
K
A
R
---
I
--
K
-
K
D
--
G
--
L
R
--
M
D
A
A
I
K
R
M
------------
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
-------------------------------
R
V
L
E
T
D
P
A
F
A
------------
I
A
N
S
T
A
S
T
L
S
S
Q
---
Q
L
-----------------------
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
---
N
Y
V
A
K
I
A
D
F
G
L
S
R
---
G
Q
E
V
Y
V
K
K
-----
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
-
A
E
-------
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
----
V
S
L
N
R
M
L
E
E
R
K
------------------------------------------------------
40
Blastp_CBE
54.57
51%
-108
- C7 -
-
3G0F
1
?
B:
[23-331]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
N
N
Y
V
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
H
M
---------
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
----------------
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
49
Blastp_CBE
54.51
50%
-104
- C7 -
-
1PKG
1
KIT_HUMAN
A:
[19-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
M
Y
-------------------
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
---------
H
M
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
I
C
S
K
-----------
A
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
-----------------------------------------------------------
41
Blastp_CBE
54.48
51%
-106
- C7 -
-
3G0F
1
?
A:
[25-331]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Y
V
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
H
M
---------
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
----------------
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
50
Blastp_CBE
54.11
51%
-106
- C7 -
-
4U0I
1
A:
[3-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
N
Y
V
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
--------
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
---------
H
M
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
I
C
S
-----------
L
A
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
33
Blastp_CBE
53.90
50%
-18
- C7 -
-
6IL3
13
A:
[32-359]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
R
Y
E
S
Q
L
Q
M
V
Q
VT
G
S
S
D
N
E
Y
F
Y
V
D
F
R
--
E
Y
E
Y
D
-
L
----------
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
----------
M
N
A
T
A
Y
G
I
--
S
-
K
T
--
G
--
V
S
--
I
Q
V
A
V
K
M
L
K
E
K
-
A
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
-
K
R
E
K
F
-------------
S
---------------------------------------------------------
N
V
-----
L
-
T
----
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
---
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
V
N
P
Y
P
G
I
P
V
D
A
N
-------
F
Y
K
L
I
Q
N
G
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
----
S
F
L
G
C
Q
L
----------------------------------------------------------
216
Blastp_CBE
53.81
44%
-59
- C7 -
-
6P69
3
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
386
Blastp_CBE
53.57
33%
-78
- C7 -
-
3LCT
3
A:
[27-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
S
G
M
--
P
-
N
D
--
P
--
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
43
Blastp_CBE
53.56
51%
-105
- C7 -
-
6ITT
2
?
B:
[20-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Y
V
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
---------
H
M
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
------------
M
E
D
D
E
L
A
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
48
Blastp_CBE
53.51
50%
-112
- C7 -
-
1PKG
2
B:
[18-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
M
Y
-------------------
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
---------
H
M
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
I
C
--------------
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
-------------
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
---------------------------------------------------------
359
Blastp_CBE
53.43
33%
-84
- C7 -
-
5IUI
1
A:
[6-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
--
D
Y
N
P
N
-
Y
S
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
S
G
---------
P
--
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-----
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
44
Blastp_CBE
53.42
51%
-101
- C7 -
-
6ITT
2
?
A:
[17-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
G
N
N
Y
V
Y
I
D
P
T
--
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
----------
V
E
A
T
A
Y
G
L
--
I
-
K
S
--
D
--
A
A
--
M
T
V
A
V
K
M
L
K
P
S
-
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
-
Y
-
L
G
N
---------
H
M
N
I
V
N
L
L
---
G
A
C
T
I
G
G
P
T
---
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
-----------
E
D
D
E
L
A
L
D
L
E
D
L
L
S
--------------------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
-------
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
171
Blastp_CBE
53.29
44%
-57
- C7 -
-
1FGI
1
FGFR1_HUMAN
A:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
160
Blastp_CBE
52.79
44%
-55
- C7 -
-
4F64
3
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
141
Blastp_CBE
52.69
44%
-62
- C7 -
-
4V05
3
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
---P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
----
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
378
Blastp_CBE
52.65
34%
-89
- C7 -
-
4CMO
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
215
Blastp_CBE
52.56
44%
-57
- C7 -
-
6P69
2
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
364
Blastp_CBE
52.38
33%
-88
- C7 -
-
4FOD
2
A:
[11-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
M
T
--
D
Y
N
P
N
-
Y
S
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
S
-------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
348
Blastp_CBE
52.33
33%
-87
- C7 -
-
4FOC
1
A:
[36-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
S
-------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
351
Blastp_CBE
52.26
34%
-89
- C7 -
-
5AAA
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
---------
L
L
E
F
M
-----------------------
A
G
G
D
L
K
S
F
L
R
E
T
R
------------------
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
372
Blastp_CBE
52.25
34%
-90
- C7 -
-
4CTC
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
356
Blastp_CBE
52.19
33%
-87
- C7 -
-
5FTO
1
A:
[1-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
N
Y
C
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
S
G
M
-----------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
387
Blastp_CBE
52.10
33%
-77
- C7 -
-
3LCS
3
A:
[30-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
S
G
M
--
P
-
N
D
--
P
--
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
383
Blastp_CBE
52.13
33%
-82
- C7 -
-
4Z55
3
A:
[22-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
-----------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
392
Blastp_CBE
52.12
33%
-78
- C7 -
-
4MKC
3
A:
[50-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
S
-------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
376
Blastp_CBE
52.11
34%
-89
- C7 -
-
4CMU
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
137
Blastp_CBE
52.10
44%
-62
- C7 -
-
5O49
1
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
---P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
-----------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
352
Blastp_CBE
52.06
34%
-93
- C7 -
-
5AA9
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
---------
L
L
E
F
M
-----------------------
A
G
G
D
L
K
S
F
L
R
E
T
R
------------------
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
173
Blastp_CBE
52.08
44%
-57
- C7 -
-
1AGW
1
FGFR1_HUMAN
A:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
34
Blastp_CBE
52.08
50%
-18
- C7 -
-
5X02
1
A:
[13-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
L
Q
M
V
Q
VT
G
S
S
D
N
E
Y
F
Y
V
D
F
R
--
E
Y
E
Y
D
-
L
----------
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
----------
M
N
A
T
A
Y
G
I
--
S
-
K
T
--
G
--
V
S
--
I
Q
V
A
V
K
M
L
K
E
K
-
A
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
-
K
R
E
K
F
-------------
S
----------------------------------------------------------
V
-----
L
-
T
----
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
---
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
V
N
P
Y
P
G
I
P
V
D
A
N
-------
F
Y
K
L
I
Q
N
G
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
----
S
F
L
G
C
Q
L
----------------------------------------------------------
177
Blastp_CBE
52.06
44%
-63
- C7 -
-
4RWL
1
B:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
---P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
379
Blastp_CBE
51.93
34%
-91
- C7 -
-
4CLI
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
370
Blastp_CBE
51.88
34%
-87
- C7 -
-
5KZ0
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
373
Blastp_CBE
51.83
34%
-91
- C7 -
-
4CTB
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
---
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
380
Blastp_CBE
51.85
34%
-89
- C7 -
-
4CCU
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
162
Blastp_CBE
51.83
44%
-55
- C7 -
-
4F63
3
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
375
Blastp_CBE
51.81
34%
-95
- C7 -
-
4CNH
1
ALK_HUMAN
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
------
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
396
Blastp_CBE
51.72
33%
-90
- C7 -
-
4ANQ
1
A:
[41-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
381
Blastp_CBE
51.74
34%
-94
- C7 -
-
4CCB
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
---
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
362
Blastp_CBE
51.73
33%
-82
- C7 -
-
4FNZ
1
A:
[10-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
-
Y
S
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
----------
Y
E
G
Q
V
S
G
------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
---------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
355
Blastp_CBE
51.72
33%
-85
- C7 -
-
5FTQ
2
A:
[1-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
N
Y
C
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
319
Blastp_CBE
51.67
35%
-132
- C7 -
-
2OSC
1
A:
[30-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
----------
L
K
A
R
---
I
---------------
M
D
A
A
I
K
R
M
K
-----
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-----
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
-------------------------------
R
V
L
E
T
D
P
A
F
A
------------
I
A
N
S
T
A
S
T
L
S
S
Q
---
Q
L
-----------------------
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
---
N
Y
V
A
K
I
A
D
F
G
L
--------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
-
A
E
-------
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
----
V
S
L
N
R
M
L
E
E
R
K
------------------------------------------------------
170
Blastp_CBE
51.66
44%
-66
- C7 -
-
1FGI
1
B:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
317
Blastp_CBE
51.63
35%
-134
- C7 -
-
2P4I
1
B:
[29-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
V
----------
L
K
A
R
---
I
------------
R
--
M
D
A
A
I
K
R
M
K
E
----
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-----
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
-------------------------------
R
V
L
E
T
D
P
A
F
A
------------
I
A
N
S
T
A
S
T
L
S
S
Q
---
Q
L
-----------------------
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
---
N
Y
V
A
K
I
A
D
F
G
L
---------------
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
-
A
E
-------
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
----
V
S
L
N
R
M
L
E
E
R
K
------------------------------------------------------
349
Blastp_CBE
51.60
33%
-84
- C7 -
-
4FOB
1
A:
[36-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
S
-------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
---
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
374
Blastp_CBE
51.54
34%
-80
- C7 -
-
4CNH
2
B:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
---
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
Y
-----
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
369
Blastp_CBE
51.48
34%
-95
- C7 -
-
6E0R
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
----
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
360
Blastp_CBE
51.46
33%
-85
- C7 -
-
5IUH
1
A:
[10-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
-
Y
S
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
-----
G
E
V
----------
Y
E
G
Q
V
S
G
-------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
---
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
-------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
261
Blastp_CBE
51.44
43%
-24
- C7 -
-
6JPJ
1
A:
[12-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
--
G
P
D
---
L
S
P
----------------------
D
G
P
R
S
S
E
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
108
Blastp_CBE
51.38
44%
-63
- C7 -
-
5A4C
7
B:
[6-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
---P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
350
Blastp_CBE
51.37
33%
-82
- C7 -
-
3AOX
5
A:
[19-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
I
M
--
T
D
Y
N
P
N
Y
C
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
110
Blastp_CBE
51.33
44%
-68
- C7 -
-
3RHX
2
B:
[5-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
361
Blastp_CBE
51.32
33%
-79
- C7 -
-
5IUG
1
A:
[10-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
-
Y
S
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
----------
Y
E
G
Q
V
S
--------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
----
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
384
Blastp_CBE
51.30
34%
-85
- C7 -
-
4TT7
5
A:
[17-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
---
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
---
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
--
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
104
Blastp_CBE
51.29
44%
-53
- C7 -
-
5Z0S
1
B:
[7-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
320
Blastp_CBE
51.22
35%
-133
- C7 -
-
2OO8
1
X:
[29-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
V
----------
L
K
A
R
---
I
------------
R
--
M
D
A
A
I
K
R
M
K
E
----
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-----
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
-------------------------------
R
V
L
E
T
D
P
A
F
A
------------
I
A
N
S
T
A
S
T
L
S
S
Q
---
Q
L
-----------------------
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
---
N
Y
V
A
K
I
A
D
F
G
L
--------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
-
A
E
-------
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
----
V
S
L
N
R
M
L
E
E
R
K
------------------------------------------------------
382
Blastp_CBE
51.16
34%
-92
- C7 -
-
2XP2
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
---
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
366
Blastp_CBE
51.09
33%
-79
- C7 -
-
4DCE
1
ALK_HUMAN
A:
[16-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
-
Y
S
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
----------
Y
E
G
Q
V
S
----------
P
--
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
--------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
71
Blastp_CBE
51.09
44%
-27
- C7 -
-
4AGD
1
A:
[34-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
I
V
M
D
P
D
--
E
L
P
----LPYDAS----
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
---------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
159
Blastp_CBE
51.07
44%
-68
- C7 -
-
4F64
3
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
363
Blastp_CBE
51.06
34%
-88
- C7 -
-
6MX8
1
A:
[17-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
--
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
-------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
367
Blastp_CBE
51.05
34%
-92
- C7 -
-
6EDL
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
----------
Y
E
G
Q
V
S
-------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
168
Blastp_CBE
51.04
44%
-69
- C7 -
-
2FGI
1
B:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
358
Blastp_CBE
50.93
33%
-86
- C7 -
-
2XB7
1
A:
[3-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
--------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
232
Blastp_CBE
50.95
43%
-23
- C7 -
-
5UI0
1
B:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-------------
M
E
Y
S
Y
-----------------------------------
D
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
72
Blastp_CBE
50.93
44%
-21
- C7 -
-
4AGC
1
A:
[33-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
I
V
M
D
P
D
--
E
L
P
----LPYDAS----
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
---------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
262
Blastp_CBE
50.91
43%
-21
- C7 -
-
4QRC
1
A:
[24-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
--
G
P
D
---
L
S
P
----------------------
D
G
P
R
S
S
E
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
174
Blastp_CBE
50.88
44%
-22
- C7 -
-
4K33
1
A:
[25-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
D
-
P
----------
K
W
E
L
S
R
A
R
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
I
G
I
--
D
-
K
D
--
R
--
A
A
KP
V
T
V
A
V
K
M
L
K
D
D
-
A
T
D
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
G
G
P
L
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
G
L
D
Y
S
---
F
D
T
S
------------------------------------------------
E
Q
-----------------
L
-
T
----
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
V
H
N
L
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
161
Blastp_CBE
50.88
44%
-62
- C7 -
-
4F63
3
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
199
Blastp_CBE
50.86
43%
-16
- C7 -
-
4J99
1
?
C:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-------------
M
E
Y
S
Y
-----------------------------------
D
-------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
336
Blastp_CBE
50.83
34%
-69
- C7 -
-
4PMS
1
A:
[7-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
--
L
--------
D
K
--
M
L
V
A
V
K
A
L
K
E
----
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
AKL
L
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
--
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
196
Blastp_CBE
50.75
43%
-20
- C7 -
-
4J96
1
FGFR2_HUMAN
B:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-------------
M
E
Y
S
Y
-----------------------------------
D
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
200
Blastp_CBE
50.71
43%
-17
- C7 -
-
4J99
1
B:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-------------
M
E
Y
S
Y
-----------------------------------
D
-------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
393
Blastp_CBE
50.66
33%
-76
- C7 -
-
3L9P
4
A:
[50-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
S
G
------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
145
Blastp_CBE
50.61
44%
-61
- C7 -
-
4V01
6
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
---P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
--------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
377
Blastp_CBE
50.55
34%
-97
- C7 -
-
4CMT
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
---
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
339
Blastp_CBE
50.53
34%
-74
- C7 -
-
6NSP
1
A:
[8-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
--
L
-
P
E
--
Q
--
D
K
--
M
L
V
A
V
K
A
L
K
E
A
-
S
E
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
A---
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
365
Blastp_CBE
50.45
33%
-84
- C7 -
-
4DCE
1
B:
[17-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
-
Y
S
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
----
E
V
----------
Y
E
G
Q
V
S
-------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
---------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
212
Blastp_CBE
50.44
43%
-20
- C7 -
-
4J97
1
FGFR2_HUMAN
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
---
G
Q
V
----------
V
M
A
E
A
V
G
I
-----
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
----------------------------------------------------------
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
169
Blastp_CBE
50.39
44%
-57
- C7 -
-
2FGI
1
FGFR1_HUMAN
A:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
-------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
-
D
I
H
H
I
D
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
213
Blastp_CBE
50.37
43%
-18
- C7 -
-
4J98
1
FGFR2_HUMAN
B:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-------------
M
E
Y
S
Y
-----------------------------------
D
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
Q
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
368
Blastp_CBE
50.25
34%
-91
- C7 -
-
6EBW
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
--
F
G
E
V
----------
Y
E
G
Q
V
S
-------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
--
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
--------------
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
172
Blastp_CBE
50.25
44%
-64
- C7 -
-
1AGW
1
B:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
338
Blastp_CBE
50.24
34%
-69
- C7 -
-
4PMM
2
A:
[7-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
--
L
--------
D
K
--
M
L
V
A
V
K
A
L
K
E
----
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
AKL
L
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
273
Blastp_CBE
50.23
43%
-19
- C7 -
-
5UGX
1
FGFR2_HUMAN
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-------------
M
E
Y
S
Y
-----------------------------------
D
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
341
Blastp_CBE
50.18
34%
-62
- C7 -
-
6NSS
1
A:
[23-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
--
L
-
P
E
--
Q
--
D
K
--
M
L
V
A
V
K
A
L
K
----
E
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
AKL
L
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
193
Blastp_CBE
50.19
44%
-65
- C7 -
-
6NVL
1
FGFR1_HUMAN
C:
[9-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
---P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
---
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
----
H
H
I
D
Y
Y
K
K
T
-----
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
249
Blastp_CBE
50.17
43%
-16
- C7 -
-
5EG3
1
A:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
------------------------------------
A
R
R
P
P
G
-------------------------------
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
F
F
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
186
Blastp_CBE
50.18
44%
-16
- C7 -
-
3C4F
1
B:
[1-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
62
Blastp_CBE
50.17
45%
-39
- C7 -
-
5EW3
1
B:
[15-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPYDAS----
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
----
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
----------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
-------------------------------------------------------------
157
Blastp_CBE
50.12
44%
-54
- C7 -
-
4F65
4
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
---P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
--------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
229
Blastp_CBE
50.01
43%
-19
- C7 -
-
2PVY
1
?
A:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-------------
M
---------------------------------------
D
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
202
Blastp_CBE
50.00
43%
-29
- C7 -
-
2PZP
1
B:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-----------------------------------------------------------
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
390
Blastp_CBE
49.99
33%
-90
- C7 -
-
4FNY
1
A:
[20-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
----------
Y
E
G
Q
V
S
G
-------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
----
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
357
Blastp_CBE
49.93
33%
-93
- C7 -
-
2XBA
1
A:
[3-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
--
S
S
I
S
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
-------
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
209
Blastp_CBE
49.91
43%
-19
- C7 -
-
4J97
1
?
D:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
---------------------------------------------------------
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
148
Blastp_CBE
49.86
44%
-11
- C7 -
-
4UWC
10
FGFR1_HUMAN
A:
[9-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
-
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
187
Blastp_CBE
49.81
44%
-14
- C7 -
-
3C4F
1
FGFR1_HUMAN
A:
[1-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
228
Blastp_CBE
49.77
43%
-18
- C7 -
-
2PVY
1
?
B:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-----------------------------------------------------
D
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
--
Y
Y
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
337
Blastp_CBE
49.76
34%
-71
- C7 -
-
4PMP
1
A:
[7-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
--
L
---------
K
--
M
L
V
A
V
K
A
L
K
-----
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
AKL
L
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
T
D
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
151
Blastp_CBE
49.75
44%
-60
- C7 -
-
4NKS
1
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
----------
V
L
A
E
A
I
G
L
------P-
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
258
Blastp_CBE
49.68
43%
-25
- C7 -
-
5UHN
1
FGFR2_HUMAN
A:
[25-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-------------------------------------------------------------------------
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
251
Blastp_CBE
49.68
43%
-24
- C7 -
-
2PY3
1
B:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
----
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-----------------------------------------------------------
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
247
Blastp_CBE
49.66
43%
-27
- C7 -
-
2Q0B
1
B:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
------------------------------------------------------------
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
226
Blastp_CBE
49.66
43%
-22
- C7 -
-
2PVY
1
?
D:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
---------------------------------------------------------
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
290
Blastp_CBE
49.53
42%
-24
- C7 -
-
6NVH
1
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
------------------------------------
A
R
R
P
P
G
-
S
S
E
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
---------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
296
Blastp_CBE
49.51
39%
-76
- C7 -
-
6NE7
2
A:
[7-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
L
E
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
A
S
L
R
G
F
L
R
E
-
S
R
K
--
V
G
--------------------------------------------------------------------
E
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
--
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------
107
Blastp_CBE
49.50
44%
-16
- C7 -
-
4ZSA
1
FGFR1_HUMAN
A:
[8-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
245
Blastp_CBE
49.44
43%
-24
- C7 -
-
2PWL
1
FGFR2_HUMAN
B:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
------------------------------------------------------------
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
75
Blastp_CBE
49.34
45%
-4
- C7 -
-
3VO3
2
A:
[9-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
-
E
HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
-----------------------------------------------
E
F
V
P
Y
K
----
D
L
Y
K
D
F
-----------------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
371
Blastp_CBE
49.31
34%
-88
- C7 -
-
5IMX
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
----------
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
224
Blastp_CBE
49.30
43%
-20
- C7 -
-
4J95
1
?
B:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
---------------------------------------------------------------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
242
Blastp_CBE
49.29
43%
-25
- C7 -
-
2PZ5
1
FGFR2_HUMAN
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
------------------------------------------------------------------------
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
208
Blastp_CBE
49.28
44%
-10
- C7 -
-
3TT0
1
FGFR1_HUMAN
A:
[57-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
67
Blastp_CBE
49.26
45%
-19
- C7 -
-
6GQP
1
?
A:
[16-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYDAS-----
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
73
Blastp_CBE
49.25
46%
-17
- C7 -
-
3WZE
2
A:
[6-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
------------------------------------------------------------
D
L
Y
K
D
---
F
-----
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
-
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
-----------------------------------------------------------
292
Blastp_CBE
49.18
42%
-16
- C7 -
-
4XCU
1
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
------------------------------------
A
R
R
P
P
G
-
S
S
E
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
230
Blastp_CBE
49.19
43%
-21
- C7 -
-
2PZR
1
B:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
------------------------------------------------------------
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
225
Blastp_CBE
49.18
43%
-23
- C7 -
-
4J95
1
FGFR2_HUMAN
A:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
---------------------------------------------------------------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
----
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
289
Blastp_CBE
49.17
42%
-24
- C7 -
-
6NVI
1
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
------------------------------------
A
R
R
P
P
---
S
E
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
-------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
238
Blastp_CBE
49.16
43%
-24
- C7 -
-
3RI1
1
?
A:
[13-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
-------------------------------------------------------------
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
321
Blastp_CBE
49.15
34%
-140
- C7 -
-
4X3J
1
A:
[37-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----------
L
K
A
-----------------
R
--
M
D
A
A
I
K
-----------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
----------
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
-------------------------------
R
V
L
E
T
D
P
A
F
A
------------
I
A
N
S
T
A
S
T
L
S
S
Q
---
Q
L
-----------------------
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
---
E
---
N
Y
V
A
K
I
A
D
F
G
------------------
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
-
A
E
-------
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
----
V
S
L
N
R
M
L
E
E
R
K
------------------------------------------------------
347
Blastp_CBE
49.09
34%
-72
- C7 -
-
5I8A
1
A:
[10-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
----------
F
L
A
E
C
H
N
-------------
K
--
M
L
V
A
V
K
A
L
K
----------
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
AKL
L
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
-
S
R
D
I
-
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
----------------------------------------------------------------------
256
Blastp_CBE
49.09
43%
-19
- C7 -
-
5UGL
1
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
-----------------------------------------------------------------------
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
252
Blastp_CBE
49.09
43%
-26
- C7 -
-
2PY3
1
FGFR2_HUMAN
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
------------------------------------------------------------------------
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
272
Blastp_CBE
49.07
43%
-17
- C7 -
-
5UGX
1
B:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-------------
M
----------------------------------------
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
V
----------
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
203
Blastp_CBE
49.06
43%
-27
- C7 -
-
2PZP
1
FGFR2_HUMAN
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
------------------------------------------------------------------------
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
295
Blastp_CBE
49.01
39%
-76
- C7 -
-
6NJA
2
A:
[7-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
L
E
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-
S
R
K
--
V
---------------------------------------------------------------------
E
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
--
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------
221
Blastp_CBE
49.01
44%
-9
- C7 -
-
5VND
10
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
353
Blastp_CBE
48.96
35%
-73
- C7 -
-
5AAB
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
--
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
--
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
---------
L
L
E
F
M
-----------------------
A
G
G
D
L
K
S
F
L
R
E
T
R
------------------
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
179
Blastp_CBE
48.98
44%
-17
- C7 -
-
4RWJ
1
FGFR1_HUMAN
A:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
318
Blastp_CBE
48.99
35%
-135
- C7 -
-
2P4I
1
TIE2_HUMAN
A:
[31-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----------
L
K
A
R
---
I
------------
R
--
M
D
A
A
I
K
R
---------------
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-----
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
-------------------------------
R
V
L
E
T
D
P
A
F
A
------------
I
A
N
S
T
A
S
T
L
S
S
Q
---
Q
L
-----------------------
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
---
N
Y
V
A
K
I
A
D
F
G
L
S
R
--------
V
K
K
T
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
-
A
E
-------
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
----
V
S
L
N
R
M
L
E
E
R
K
------------------------------------------------------
220
Blastp_CBE
48.97
44%
-18
- C7 -
-
5VND
9
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
--------------
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
59
Blastp_CBE
48.98
49%
-14
- C7 -
-
3VHE
1
A:
[9-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
-
P
Y
---
K
--------------------------------------------------------
D
L
Y
K
D
---
F
-----
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
---------------------------------------------------------
150
Blastp_CBE
48.97
44%
-11
- C7 -
-
4UWB
4
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
-----
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
70
Blastp_CBE
48.96
44%
-8
- C7 -
-
4ASD
1
A:
[39-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
--
E
L
P
L
D
-
E
HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
---------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
275
Blastp_CBE
48.91
43%
-30
- C7 -
-
5NWZ
1
FGFR4_HUMAN
A:
[8-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
--
G
P
D
---
L
----------------------------------------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
246
Blastp_CBE
48.91
43%
-22
- C7 -
-
2PWL
1
FGFR2_HUMAN
A:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
--------------------------------------------------------------
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
285
Blastp_CBE
48.84
43%
-23
- C7 -
-
6IUP
2
?
A:
[23-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
---
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
------------------------------------
P
R
S
S
E
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
69
Blastp_CBE
48.83
44%
-9
- C7 -
-
4ASE
1
A:
[39-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
--
E
L
P
L
D
-
E
HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
---------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
343
Blastp_CBE
48.82
34%
-101
- C7 -
-
6NPT
1
A:
[17-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
--
L
-
P
E
--
Q
--
D
K
--
M
L
V
A
V
K
A
L
K
E
------
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
------
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
T
D
Y
-
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
98
Blastp_CBE
48.81
46%
-17
- C7 -
-
2P2I
1
VGFR2_HUMAN
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
--------
T
C
--
R
T
V
A
V
K
M
L
-----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
183
Blastp_CBE
48.71
44%
-14
- C7 -
-
3JS2
1
FGFR1_HUMAN
A:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
----------
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
74
Blastp_CBE
48.71
46%
-18
- C7 -
-
3WZD
10
A:
[7-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
----
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
---
F
-----
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
-----------------------------------------------------------
569
Fugue
48.62
32%
-22
- C7 -
-
3CD3
3
A:
[1-376]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
LLV
H
S
G
D
F
L
V
R
E
S
Q
E
Y
V
L
S
V
P
R
---------
H
F
I
I
N
L
Y
R
L
F
P
S
I
P
L
L
I
D
--
H
L
L
S
T
Q
Q
P
L
S
G
V
V
LH
R
A
V
P
K
-
D
----------
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
----------
F
S
G
R
L
R
A
D
--
N
-
T
-----------
L
V
A
V
K
S
C
R
P
-----
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
A
R
-------------------------------------------------------------------------------
L
-
R
----
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
---
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
-
A
D
G
V
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
-
L
S
N
Q
Q
-------
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
----
Q
E
L
Q
S
I
R
K
R
H
-------------------------------------------------------
241
Blastp_CBE
48.68
43%
-28
- C7 -
-
2PZ5
1
B:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
-------------------------------------------------------------
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
57
Blastp_CBE
48.67
49%
-11
- C7 -
-
3HNG
1
A:
[13-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
A
R
E
R
L
K
L
G
K
S
L
G
R
G
A
F
G
K
V
----------
V
Q
A
S
A
F
G
I
--
K
-
K
S
--
P
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
A
S
E
Y
K
A
L
M
T
E
L
K
I
L
T
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
Q
-
G
G
P
L
M
V
I
V
E
Y
C
K
Y
G
N
L
S
N
Y
L
K
S
-
K
R
-------------------------------------------------------------------------
K
E
P
-----
I
-
T
----
M
E
D
L
I
S
Y
S
F
Q
V
A
R
G
M
E
F
L
S
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
N
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
N
P
D
Y
V
R
K
--
T
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
I
Y
S
T
K
S
D
V
W
S
Y
G
V
L
L
W
E
I
F
S
L
G
G
S
P
Y
P
G
V
Q
M
D
E
D
-------
F
C
S
R
L
R
E
G
M
R
M
R
A
P
E
Y
S
T
P
E
I
Y
Q
I
M
L
D
C
W
H
R
D
P
K
E
R
P
R
F
A
E
L
V
----
E
K
L
--------------------------------------------------------------
147
Blastp_CBE
48.64
44%
-16
- C7 -
-
4UWC
9
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
---
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
223
Blastp_CBE
48.62
43%
-17
- C7 -
-
4J95
1
?
C:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
---------------------------------------------------------------------------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
248
Blastp_CBE
48.63
43%
-25
- C7 -
-
2Q0B
1
FGFR2_HUMAN
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
------------------------------------------------------------------------
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
105
Blastp_CBE
48.62
44%
-11
- C7 -
-
5Z0S
1
FGFR1_HUMAN
A:
[7-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
176
Blastp_CBE
48.61
44%
-15
- C7 -
-
5AM7
1
FGFR1_HUMAN
A:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
-------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
201
Blastp_CBE
48.58
43%
-19
- C7 -
-
4J99
1
FGFR2_HUMAN
A:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
---------------------------------------------------------------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
--
D
Y
Y
K
--
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
297
Blastp_CBE
48.54
39%
-72
- C7 -
-
4CKI
8
A:
[7-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
L
E
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-
S
R
K
--
V
--------------------------------------------------------------------
D
E
R
A
-----
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
--
V
K
R
S
Q
G
R
I
P
V
K
W
T
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------
135
Blastp_CBE
48.56
44%
-20
- C7 -
-
5O4A
1
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
------
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
185
Blastp_CBE
48.54
44%
-13
- C7 -
-
4RWK
1
FGFR1_HUMAN
A:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
231
Blastp_CBE
48.51
43%
-23
- C7 -
-
2PZR
1
FGFR2_HUMAN
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
------------------------------------------------------------
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
184
Blastp_CBE
48.50
44%
-25
- C7 -
-
4RWK
1
B:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
--
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
142
Blastp_CBE
48.49
44%
-16
- C7 -
-
4V05
4
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
--------------
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
103
Blastp_CBE
48.49
44%
-9
- C7 -
-
6ITJ
1
?
A:
[8-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
335
Blastp_CBE
48.45
34%
-76
- C7 -
-
4PMT
1
A:
[7-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
-----------
D
K
--
M
L
V
A
V
K
A
L
-----------
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
AKL
L
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
429
Blastp_CBE
48.42
31%
-67
- C7 -
-
5BVW
1
A:
[15-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDS----------------------
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
K
---------------------------------------
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
----
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
274
Blastp_CBE
48.45
43%
-31
- C7 -
-
5NWZ
1
B:
[8-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
-------------------------------------------------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
111
Blastp_CBE
48.42
44%
-9
- C7 -
-
3RHX
5
FGFR1_HUMAN
A:
[5-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
198
Blastp_CBE
48.41
43%
-23
- C7 -
-
4J99
1
?
D:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
---------------------------------------------------------------------------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
88
Blastp_CBE
48.30
46%
-18
- C7 -
-
3B8Q
1
B:
[6-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
------------------------------------------------------------
125
Blastp_CBE
48.29
44%
-13
- C7 -
-
5UR1
1
FGFR1_HUMAN
A:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
-
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
--------
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
140
Blastp_CBE
48.28
44%
-15
- C7 -
-
5EW8
1
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
--------------
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
259
Blastp_CBE
48.23
43%
-18
- C7 -
-
4UXQ
1
A:
[10-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
----------------------------------------
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
346
Blastp_CBE
48.25
34%
-70
- C7 -
-
5KVT
2
A:
[7-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
-----------
D
K
--
M
L
V
A
V
K
A
L
K
E
A
-
S
E
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
AKL
L
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
----------------------------------------------------------------------
278
Blastp_CBE
48.22
43%
-31
- C7 -
-
4TYJ
2
A:
[12-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
--------------------------------------------------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
---------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
64
Blastp_CBE
48.24
45%
-8
- C7 -
-
4AG8
1
A:
[11-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
---------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
166
Blastp_CBE
48.23
44%
-15
- C7 -
-
5AM6
1
FGFR1_HUMAN
A:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
--------------
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
66
Blastp_CBE
48.23
45%
-5
- C7 -
-
6GQQ
1
A:
[8-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
-
E
HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
-----------------------------------------------------------
191
Blastp_CBE
48.22
44%
-17
- C7 -
-
5ZV2
1
FGFR1_HUMAN
A:
[5-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
-------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
--
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
219
Blastp_CBE
48.19
44%
-5
- C7 -
-
6P68
1
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
175
Blastp_CBE
48.17
44%
-14
- C7 -
-
5AM7
1
B:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
-------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
76
Blastp_CBE
48.17
45%
-1
- C7 -
-
3VNT
4
A:
[9-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
-
E
HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
-----------------------------------------------
E
F
V
P
Y
K
------
Y
K
D
F
-----------------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
389
Blastp_CBE
48.09
34%
-65
- C7 -
-
5A9U
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
--
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
302
Blastp_CBE
48.13
38%
-81
- C7 -
-
5AMN
7
A:
[7-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
--
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-
S
R
K
--
V
---------------------------------------------
E
R
A
L
T
M
G
D
L
I
S
F
A
W
Q
----------------------------------
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
--
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
------------------------------------------------------------
149
Blastp_CBE
48.10
44%
-15
- C7 -
-
4UWB
3
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
---
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
68
Blastp_CBE
48.09
45%
-3
- C7 -
-
6GQO
1
A:
[6-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
E
HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
65
Blastp_CBE
48.09
45%
-6
- C7 -
-
2XIR
1
A:
[11-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
---------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
432
Blastp_CBE
48.07
31%
-57
- C7 -
-
5BVK
1
A:
[15-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDS----------------------
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
K
---------------------------------------
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
61
Blastp_CBE
48.06
47%
-10
- C7 -
-
3EWH
2
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
--------
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
-----
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
164
Blastp_CBE
47.99
44%
-9
- C7 -
-
5B7V
1
FGFR1_HUMAN
A:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
--------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
106
Blastp_CBE
47.94
44%
-16
- C7 -
-
4ZSA
1
B:
[7-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
102
Blastp_CBE
47.94
44%
-9
- C7 -
-
6ITJ
1
?
B:
[7-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
-----
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
129
Blastp_CBE
47.87
44%
-16
- C7 -
-
4WUN
1
FGFR1_HUMAN
A:
[11-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
-
L
E
Y
S
---
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
93
Blastp_CBE
47.86
46%
-11
- C7 -
-
2QU5
1
A:
[5-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
-------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
--------------------------------------------------------
109
Blastp_CBE
47.83
44%
-8
- C7 -
-
5A4C
6
FGFR1_HUMAN
A:
[6-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
388
Blastp_CBE
47.77
34%
-67
- C7 -
-
5AAC
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
--
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
227
Blastp_CBE
47.77
43%
-18
- C7 -
-
2PVY
1
?
C:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
G
-------------
M
E
------------------------------------------
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
--
Y
Y
K
---
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
255
Blastp_CBE
47.75
43%
-21
- C7 -
-
5UGL
1
?
B:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
---------------------------------------------------------------------
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
178
Blastp_CBE
47.77
44%
-23
- C7 -
-
4RWJ
1
B:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
---------
Y
K
K
T
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
83
Blastp_CBE
47.75
46%
-23
- C7 -
-
3CP9
1
B:
[5-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
-----------------------------------------------------------
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
-------------------------------------------------------------
288
Blastp_CBE
47.73
42%
-26
- C7 -
-
6NVJ
1
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
------------------------------------
A
R
R
P
P
G
-
S
S
E
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
136
Blastp_CBE
47.72
44%
-11
- C7 -
-
5O4A
2
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
--------------
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
115
Blastp_CBE
47.70
44%
-19
- C7 -
-
6C1O
1
FGFR1_HUMAN
A:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
--------
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
87
Blastp_CBE
47.67
46%
-13
- C7 -
-
3B8R
2
VGFR2_HUMAN
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
113
Blastp_CBE
47.62
44%
-15
- C7 -
-
6MZQ
1
FGFR1_HUMAN
A:
[10-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
N
P
S
---
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
56
Blastp_CBE
47.62
48%
-6
- C7 -
-
3VHK
2
A:
[11-365]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
E
HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
-
P
Y
---
K
----------------------------------------------------------
Y
K
D
---
F
-----
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
243
Blastp_CBE
47.58
43%
-15
- C7 -
-
5A46
2
B:
[28-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
-
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
86
Blastp_CBE
47.57
46%
-18
- C7 -
-
3B8R
1
B:
[7-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
------------------------------------------------------------
89
Blastp_CBE
47.56
46%
-7
- C7 -
-
3B8Q
1
VGFR2_HUMAN
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
90
Blastp_CBE
47.52
46%
-8
- C7 -
-
2RL5
1
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
--------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
222
Blastp_CBE
47.50
43%
-24
- C7 -
-
4J95
2
?
D:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
---------------------------------------------------------------------------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
91
Blastp_CBE
47.47
46%
-17
- C7 -
-
2QU6
1
B:
[8-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
-------------------------------------------------------------------
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
-------------------------------------------------------------
94
Blastp_CBE
47.46
46%
-15
- C7 -
-
2P2H
1
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
---------------
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
58
Blastp_CBE
47.45
49%
-2
- C7 -
-
3VID
1
A:
[7-348]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
-
P
Y
---
K
------------------------------------------------
E
-
A
P
E
---
D
L
Y
K
D
---
F
-----
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
-------
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
----
E
H
L
--------------------------------------------------------------
81
Blastp_CBE
47.44
46%
-20
- C7 -
-
3CPB
1
B:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---------------------------------------------------------------
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
-------------------------------------------------------------
431
Blastp_CBE
47.43
31%
-54
- C7 -
-
5BVN
1
A:
[15-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDS----------------------
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
K
---------------------------------------
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
190
Blastp_CBE
47.41
44%
-23
- C7 -
-
5ZV2
1
B:
[5-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
----------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-------
D
Y
Y
K
K
T
---
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
96
Blastp_CBE
47.41
46%
-13
- C7 -
-
3EFL
1
VGFR2_HUMAN
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
--------
T
C
--
R
T
V
A
V
K
M
L
K
E
---
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
165
Blastp_CBE
47.39
44%
-14
- C7 -
-
5AM6
1
B:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
-------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
123
Blastp_CBE
47.37
44%
-5
- C7 -
-
6C18
1
FGFR1_HUMAN
A:
[11-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
---
S
---
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
95
Blastp_CBE
47.37
46%
-22
- C7 -
-
3EFL
1
B:
[7-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
-----------------------------------------------------------------
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
-------------------------------------------------------------
253
Blastp_CBE
47.35
43%
-15
- C7 -
-
3B2T
1
B:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
----------
V
M
A
E
A
V
G
I
-----
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
--------------------------------------------------------------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
116
Blastp_CBE
47.32
44%
-25
- C7 -
-
6C1C
1
B:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
-
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
---KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
--------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
205
Blastp_CBE
47.30
44%
-15
- C7 -
-
3GQL
1
FGFR1_HUMAN
B:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
--------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
291
Blastp_CBE
47.27
42%
-27
- C7 -
-
6NVG
1
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
------------------------------------
A
R
R
P
P
G
-
S
S
E
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
234
Blastp_CBE
47.27
44%
-41
- C7 -
-
3GQI
2
A:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
F
S
---
F
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
K
K
T
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
121
Blastp_CBE
47.26
44%
-16
- C7 -
-
6C19
1
FGFR1_HUMAN
A:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
--
E
Y
S
---
Y
N
P
S
---
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
139
Blastp_CBE
47.25
44%
-13
- C7 -
-
5EW8
1
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
--
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
354
Blastp_CBE
47.16
35%
-67
- C7 -
-
5AA8
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
--
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
---------
L
L
E
F
M
-----------------------
A
G
G
D
L
K
S
F
L
R
E
T
R
------------------
P
R
P
S
Q
P
S
S
------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
154
Blastp_CBE
47.15
44%
-6
- C7 -
-
4NKA
3
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
257
Blastp_CBE
47.14
43%
-26
- C7 -
-
5UHN
2
B:
[25-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
---------------------------------------------------------------------------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
254
Blastp_CBE
47.13
43%
-11
- C7 -
-
3B2T
1
FGFR2_HUMAN
A:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
------PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
--------------------------------------------------------------
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
244
Blastp_CBE
47.10
43%
-10
- C7 -
-
5A46
4
FGFR1_HUMAN
A:
[28-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
-------------
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
-
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
112
Blastp_CBE
47.07
44%
-24
- C7 -
-
6MZQ
1
B:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
----------------------------------------------------------------------------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
-------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
344
Blastp_CBE
47.06
34%
-65
- C7 -
-
6PL2
1
A:
[23-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
--
L
-
P
E
--
Q
--
D
K
--
M
L
V
A
V
K
A
L
K
E
A
-
S
E
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
AKL
L
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
T
D
Y
-
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
385
Blastp_CBE
46.98
33%
-101
- C7 -
-
4JOA
1
A:
[41-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
L
----------
K
-
E
V
P
R
K
N
I
T
L
I
R
G
L
G
------
V
----------
Y
E
G
Q
V
S
-----------------
L
Q
V
A
V
K
T
L
P
----------
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
L
P
R
F
I
L
L
-----------------
E
L
M
A
G
G
D
---
L
------------------
K
S
F
L
R
E
------------
T
R
P
R
------------------------------
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------
A
M
L
P
V
K
W
M
P
P
E
A
---
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
124
Blastp_CBE
47.02
44%
-24
- C7 -
-
5UR1
1
B:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
--------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
287
Blastp_CBE
46.98
42%
-22
- C7 -
-
6NVK
1
A:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
------------------------------------
A
R
R
P
P
G
-
S
S
E
G
--------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
264
Blastp_CBE
46.98
43%
-45
- C7 -
-
3CLY
1
FGFR2_HUMAN
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-------------------------------------------------------------------------
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
K
K
T
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
79
Blastp_CBE
46.94
46%
-21
- C7 -
-
3CPC
1
B:
[6-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
----------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
-------------------------------------------------------------
189
Blastp_CBE
46.92
44%
-14
- C7 -
-
6MZW
1
FGFR1_HUMAN
A:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
N
P
S
--
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
63
Blastp_CBE
46.93
45%
-24
- C7 -
-
5EW3
1
VGFR2_HUMAN
A:
[16-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYDAS-----
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
-----------------------------------------------------------
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
182
Blastp_CBE
46.92
44%
-12
- C7 -
-
3JS2
1
B:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
237
Blastp_CBE
46.90
43%
-21
- C7 -
-
3RI1
1
FGFR2_HUMAN
B:
[13-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
------PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-----------
P
P
-------------------------------------------------------------
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
80
Blastp_CBE
46.87
46%
-10
- C7 -
-
3CPC
1
VGFR2_HUMAN
A:
[6-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
345
Blastp_CBE
46.83
34%
-67
- C7 -
-
6PL1
1
?
A:
[23-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
--
L
-
P
E
--
Q
--
D
K
--
M
L
V
A
V
K
A
L
K
----
E
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
AKL
L
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
T
D
Y
-
Y
R
V
G
---
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
117
Blastp_CBE
46.85
44%
-8
- C7 -
-
6C1C
1
FGFR1_HUMAN
A:
[11-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
----
S
---
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
195
Blastp_CBE
46.84
44%
-13
- C7 -
-
6NVL
1
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
-------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
--------
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
276
Blastp_CBE
46.83
43%
-22
- C7 -
-
5NUD
1
B:
[8-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
-------------------------------------------------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
------------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
53
Blastp_CBE
46.82
48%
-21
- C7 -
-
1Y6B
1
A:
[14-363]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLPYDAS---
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
-
P
Y
--------------------------------------------------------------------
F
-----
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
84
Blastp_CBE
46.81
46%
-8
- C7 -
-
3CP9
1
VGFR2_HUMAN
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
128
Blastp_CBE
46.80
44%
-26
- C7 -
-
4WUN
1
B:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
-------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
158
Blastp_CBE
46.79
44%
-15
- C7 -
-
4F65
6
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
--------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
----------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
120
Blastp_CBE
46.78
44%
-23
- C7 -
-
6C19
1
B:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
430
Blastp_CBE
46.72
31%
-61
- C7 -
-
5BVO
1
A:
[15-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
--
F
G
E
V
HLCEVDS----------------------
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
K
---------------------------------------
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
206
Blastp_CBE
46.66
44%
-15
- C7 -
-
3GQL
1
FGFR1_HUMAN
A:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
250
Blastp_CBE
46.65
43%
-55
- C7 -
-
2PVF
1
A:
[23-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
P-----
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------------------------------------
A
R
R
P
P
G
M
E
S
Y
D
--------------------------------------
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
K
K
T
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
235
Blastp_CBE
46.60
43%
-18
- C7 -
-
1OEC
1
A:
[15-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--------
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--------------------------------------------------------------------------
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
85
Blastp_CBE
46.59
46%
-8
- C7 -
-
3BE2
1
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
--------
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
77
Blastp_CBE
46.58
46%
-18
- C7 -
-
3DTW
1
B:
[6-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
--------------------------------------------------------------
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
----------------
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
------------------------------------------------------------
268
Blastp_CBE
46.57
42%
-31
- C7 -
-
6AGX
1
?
C:
[1-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------------------------------------
A
R
R
P
---------------------------------
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
---
K
K
T
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
97
Blastp_CBE
46.54
46%
-21
- C7 -
-
2P2I
1
B:
[6-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
-----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
-----------------------------------------------------------------
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
----------------------------------------------------------
144
Blastp_CBE
46.53
44%
-3
- C7 -
-
4V04
7
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
-----
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
82
Blastp_CBE
46.53
46%
-7
- C7 -
-
3CPB
1
VGFR2_HUMAN
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
163
Blastp_CBE
46.52
44%
-17
- C7 -
-
5B7V
1
B:
[9-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
----------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
K
K
T
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
218
Blastp_CBE
46.44
44%
-9
- C7 -
-
6P68
1
FGFR1_HUMAN
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
----------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
153
Blastp_CBE
46.40
44%
-10
- C7 -
-
4NKA
2
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
------
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
217
Blastp_CBE
46.33
44%
-3
- C7 -
-
6P68
1
C:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
---------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
279
Blastp_CBE
46.28
43%
-25
- C7 -
-
4TYI
1
A:
[12-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
-------------------------------------------------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
G
--------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
277
Blastp_CBE
46.27
43%
-25
- C7 -
-
5NUD
1
FGFR4_HUMAN
A:
[8-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
--------------------------------------------------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
342
Blastp_CBE
46.26
34%
-68
- C7 -
-
5WR7
1
A:
[19-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
----------
F
L
A
E
C
H
N
L
--
L
-
P
E
--
Q
--
D
K
--
M
L
V
A
V
K
A
L
K
E
A
-
S
E
S
-
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
-
L
N
R
F
L
R
-
S
H
----
G
P
D
AKL
L
A
G
G
E
D
V
A
P
G
-------------------------------------------------------
P
-----
L
-
G
----
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
T
D
Y
-
Y
R
V
G
G
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
-------
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----
A
R
L
Q
A
L
A
Q
---------------------------------------------------------
54
Blastp_CBE
46.24
48%
-32
- C7 -
-
1Y6A
1
A:
[15-362]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPYDAS----
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
-----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
-
P
Y
----------------------------------------------------------------
D
---
F
-----
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
-----------------------------------------------------------
433
Blastp_CBE
46.19
31%
-55
- C7 -
-
5FDX
5
B:
[29-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDS-----------------------
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
K
A
-------------------------------------
G
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
------------------------------------------------------------
119
Blastp_CBE
46.15
44%
-20
- C7 -
-
6C1B
1
FGFR1_HUMAN
A:
[11-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
----------------
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
188
Blastp_CBE
46.14
44%
-24
- C7 -
-
6MZW
1
B:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
--------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
156
Blastp_CBE
46.13
44%
-11
- C7 -
-
4NK9
5
FGFR1_HUMAN
A:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
--
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
99
Blastp_CBE
46.11
45%
-15
- C7 -
-
1YWN
1
A:
[15-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPYDAS----
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
-----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
-------------------------------------------------------------------
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
-----
I
K
D
P
D
Y
-
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------
204
Blastp_CBE
46.09
44%
-18
- C7 -
-
3GQL
1
C:
[16-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
143
Blastp_CBE
46.06
44%
-11
- C7 -
-
4V04
6
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
207
Blastp_CBE
46.03
44%
-19
- C7 -
-
3TT0
4
B:
[57-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
-
K
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
270
Blastp_CBE
45.99
42%
-32
- C7 -
-
6AGX
1
FGFR2_HUMAN
A:
[1-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------------------------------------
A
R
R
P
--------------------------------
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
---
K
K
T
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
260
Blastp_CBE
45.98
43%
-22
- C7 -
-
5JKG
1
A:
[12-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
----
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
--
G
P
---------------------------------------------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
266
Blastp_CBE
45.93
43%
-21
- C7 -
-
5XFF
1
A:
[12-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
N
-
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
--
G
P
---------------------------------------------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
122
Blastp_CBE
45.87
44%
-23
- C7 -
-
6C18
1
B:
[12-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
---------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
488
Blastp_CBE
45.83
44%
-162
- C7 -
-
2HK5
1
HCK_HUMAN
A:
[100-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
S
D
E
G
S
K
-----
Q
-
P
----
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
-
V
I
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
-------
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
----
S
V
L
D
D
------------------------------------------------------------
155
Blastp_CBE
45.69
44%
-6
- C7 -
-
4NK9
2
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
-------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
--------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
311
Blastp_CBE
45.64
37%
-61
- C7 -
-
6FEK
3
A:
[7-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
A
F
--
K
I
L
A
A
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-
S
R
K
---------
V
G
P
G
P
D
E
R
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
--------
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
-----------------------------------
R
D
--------------
L
A
A
R
N
----------
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
--
F
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
-------------------------------------------------------
146
Blastp_CBE
45.55
44%
-6
- C7 -
-
4V01
7
FGFR1_HUMAN
A:
[9-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
-------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
78
Blastp_CBE
45.28
46%
-5
- C7 -
-
3DTW
1
VGFR2_HUMAN
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
------
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
92
Blastp_CBE
45.24
46%
-10
- C7 -
-
2QU6
1
VGFR2_HUMAN
A:
[5-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
------
T
C
--
R
T
V
A
V
K
M
L
K
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
P
Y
K
---
V
A
P
--------------------------------------------------
E
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
265
Blastp_CBE
45.23
43%
-24
- C7 -
-
5XFJ
1
A:
[12-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
----------
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
----------
V
R
A
E
A
F
G
M
DP
A
-
R
P
--
D
--
Q
A
--
S
T
V
A
V
K
M
L
K
D
----
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
G
P
L
Y
V
I
M
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
P
P
--
G
P
---------------------------------------------------------------------
P
-----
L
-
S
----
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
-
E
-------
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
----
E
A
L
D
K
------------------------------------------------------------
194
Blastp_CBE
45.16
44%
-15
- C7 -
-
6NVL
1
FGFR1_HUMAN
B:
[8-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
-------
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
----------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
114
Blastp_CBE
44.96
44%
-23
- C7 -
-
6C1O
1
B:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
----------
V
L
A
E
A
I
G
L
------KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
--------------------------------------------------------------
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
127
Blastp_CBE
44.70
44%
-22
- C7 -
-
5UQ0
1
FGFR1_HUMAN
A:
[10-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
----------
V
L
A
E
A
I
G
L
--
D
---KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
-------------------------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
--
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
422
Blastp_CBE
44.57
31%
-30
- C7 -
-
6GWR
12
DDR1_HUMAN
A:
[6-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD
L
V
S
L
D
F
P
L
--------
G
--
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
K
A
A
E
----------------------------------
Q
G
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
412
Blastp_CBE
44.50
31%
-58
- C7 -
-
3EKN
1
A:
[8-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
-
D
----------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
----------
Y
E
G
N
A
R
D
I
--
I
-
K
G
--
E
--
A
E
--
T
R
V
A
V
K
T
V
N
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
----
E
---
N
N
P
G
R
P
P
P
---------------------------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
------------------
L
-
N
----
A
K
K
F
V
H
R
N
---------
L
A
A
R
N
C
----------
M
V
A
---
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
-------
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
----
N
L
L
K
D
------------------------------------------------------------
421
Blastp_CBE
44.27
31%
-33
- C7 -
-
6GWR
8
B:
[6-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD
L
V
S
-----------------
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
K
A
A
------------------------------------
G
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
-----------------------------------------------------------
192
Blastp_CBE
43.87
44%
-12
- C7 -
-
6NVL
1
D:
[15-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
--------
Q
V
----------
V
L
A
E
A
I
G
L
-----
D
KP
N
--
R
V
--
T
K
V
A
V
K
M
L
K
S
---
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
P
P
G
L
E
Y
S
---
Y
N
P
S
H
N
P
E
--------------------------------------------
E
Q
-----------------
L
-
S
----
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
---
D
N
V
M
K
I
A
D
F
G
L
---------
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
419
Blastp_CBE
43.66
31%
-31
- C7 -
-
6HP9
1
B:
[6-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD
L
------------------
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
---------------------------------------
G
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
434
Blastp_CBE
43.65
31%
-32
- C7 -
-
5FDX
6
DDR1_HUMAN
A:
[28-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD
L
V
-----------------
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
----------------------------------------
G
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
435
Blastp_CBE
43.44
31%
-30
- C7 -
-
5FDP
7
A:
[28-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD-------------------
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
K
A
A
------------------------------------
G
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
413
Blastp_CBE
43.25
31%
-60
- C7 -
-
3EKK
1
A:
[4-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
--
S
V
Y
V
P
-
D
----------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
----------
Y
E
G
N
A
R
D
I
--
I
-
K
G
--
E
--
A
E
--
T
R
V
A
V
K
T
V
N
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
----
E
---
N
N
P
G
R
P
P
P
---------------------------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
------------------
L
-
N
----
A
K
K
F
V
H
R
N
---------
L
A
A
R
N
C
----------
M
V
A
---
H
---
D
F
T
V
K
I
G
D
F
------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
-------
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
----
N
L
L
K
D
------------------------------------------------------------
418
Blastp_CBE
43.17
34%
-40
- C7 -
-
4CD0
1
A:
[41-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
-----------------------------------------------
E
V
C
S
E
Q
D
E
L
D
F
L
----
M
E
A
L
I
I
S
K
---
F
----------
N
H
Q
N
I
-------
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
-------
L
R
E
T
R
P
R
P
SQPSS
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
518
Blastp_CBE
42.78
44%
-150
- C7 -
-
5ZJ6
1
HCK_HUMAN
B:
[111-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
S
D
E
G
S
K
-----
Q
-
P
----
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
-
V
I
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
-------
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
----
S
V
L
D
D
------------------------------------------------------------
519
Blastp_CBE
42.76
44%
-150
- C7 -
-
5ZJ6
1
HCK_HUMAN
A:
[111-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
S
D
E
G
S
K
-----
Q
-
P
----
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
-
V
I
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
-------
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
----
S
V
L
D
D
------------------------------------------------------------
416
Blastp_CBE
42.51
34%
-41
- C7 -
-
4CLJ
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
----------
Y
E
G
Q
V
--------------
S
P
--
L
Q
V
A
V
K
T
L
P
-----------------------------------------------
E
V
C
S
E
Q
D
E
L
D
F
L
----
M
E
A
L
I
I
S
K
---
F
----------
N
H
Q
N
I
-------
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
-------
L
R
E
T
R
P
R
P
SQPSS
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
100
Blastp_CBE
42.47
45%
-6
- C7 -
-
2OH4
1
A:
[12-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HCERLPYDAS
K
W
E
F
P
R
D
R
L
N
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
--
A
--
T
C
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
N
E
F
V
--------
P
Y
--------------------------------
Y
K
D
F
-------------------------------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
K
D
P
D
--
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------
423
Blastp_CBE
42.43
31%
-21
- C7 -
-
4CKR
6
A:
[6-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD
L
V
S
L
D
F
P
L
--
N
V
R
K
--
G
--
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
----------------------------------------
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
----
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
269
Blastp_CBE
42.34
42%
-28
- C7 -
-
6AGX
1
B:
[1-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------------------------------------
A
R
R
P
P
G
M
-----------------------
E
S
---
D
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
K
K
T
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
427
Blastp_CBE
42.27
31%
-9
- C7 -
-
3ZOS
4
DDR1_HUMAN
A:
[6-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD
L
V
S
L
D
F
P
L
--
N
V
R
K
--
G
--
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
------------------------------------
A
A
Q
G
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
428
Blastp_CBE
42.15
33%
-39
- C7 -
-
4ANS
1
A:
[41-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
-----------------------------------------------
E
V
C
S
E
Q
D
E
L
D
F
L
----
M
E
A
L
I
I
S
K
---
F
----------
N
H
Q
N
I
-------
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
-------
L
R
E
T
R
P
R
P
SQPSS
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
420
Blastp_CBE
42.04
31%
-13
- C7 -
-
6HP9
1
DDR1_HUMAN
A:
[6-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD
L
V
S
L
D
F
P
L
--
N
V
R
K
--
G
--
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
---------------------------------------
Q
G
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
426
Blastp_CBE
41.99
31%
-13
- C7 -
-
3ZOS
3
B:
[6-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD
L
V
S
L
D
F
P
L
--
N
V
R
K
--
G
--
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
K
-------------------------------------
Q
G
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
490
Blastp_CBE
41.87
42%
-153
- C7 -
-
2HZ4
1
ABL1_HUMAN
B:
[113-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
---------------------------------------------------------
267
Blastp_CBE
41.84
42%
-25
- C7 -
-
6AGX
1
?
D:
[1-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
----------
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
----------
V
M
A
E
A
V
G
I
--
D
-
K
D
--
K
PK
E
A
--
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
------------------------------------
A
R
R
P
P
G
M
-----------------------
E
S
---
D
I
N
R
V
P
E
E
Q
-----
M
-
T
----
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
---
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
K
K
T
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
-
E
E
-------
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
----
E
D
L
--------------------------------------------------------------
522
Blastp_CBE
41.81
42%
-150
- C7 -
-
4TWP
1
ABL1_HUMAN
B:
[108-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------
417
Blastp_CBE
41.63
34%
-38
- C7 -
-
2YFX
1
A:
[26-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
----------
Y
E
G
Q
V
---------------
P
--
L
Q
V
A
V
K
T
L
P
-----------------------------------------------
E
V
C
S
E
Q
D
E
L
D
F
L
----
M
E
A
L
I
I
S
K
---
F
----------
N
H
Q
N
I
-------
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
-------
L
R
E
T
R
P
R
P
SQPSS
L
-
A
----
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
-------
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
----
E
R
I
E
Y
C
T
Q
D
--------------------------------------------------------
502
Blastp_CBE
41.57
41%
-148
- C7 -
-
3UE4
1
ABL1_HUMAN
B:
[115-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
---------------------------------------------------------
515
Blastp_CBE
41.53
42%
-151
- C7 -
-
2HZI
1
ABL1_HUMAN
B:
[117-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------
472
Blastp_CBE
41.52
41%
-147
- C7 -
-
1M52
3
ABL1_MOUSE
B:
[118-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------
425
Blastp_CBE
41.36
31%
-16
- C7 -
-
4BKJ
10
DDR1_HUMAN
A:
[6-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD
L
V
S
L
D
F
P
L
--
N
V
R
K
--
G
--
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
----------------------------------------
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
514
Blastp_CBE
41.28
42%
-140
- C7 -
-
3CS9
1
ABL1_HUMAN
A:
[117-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------
526
Blastp_CBE
41.26
41%
-141
- C7 -
-
2G2H
1
ABL1_HUMAN
B:
[115-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------
480
Blastp_CBE
41.21
41%
-143
- C7 -
-
4WA9
1
ABL1_HUMAN
A:
[114-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------
424
Blastp_CBE
41.17
31%
-14
- C7 -
-
4BKJ
10
B:
[6-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
HLCEVDSPQD
L
V
S
L
D
F
P
L
--
N
V
R
K
--
G
--
H
P
--
L
L
V
A
V
K
I
L
R
P
D
-
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-
H
Q
L
E
D
K
--------------------------------------
G
P
T
I
S
Y
P
M
-----------------------------------------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
---
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
VIENAGE
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
----
R
F
L
A
E
D
A
----------------------------------------------------------
523
Blastp_CBE
41.15
42%
-150
- C7 -
-
4TWP
1
ABL1_HUMAN
A:
[108-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------
516
Blastp_CBE
41.14
42%
-143
- C7 -
-
2HZI
1
ABL1_HUMAN
A:
[117-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------
483
Blastp_CBE
41.13
41%
-145
- C7 -
-
4ZOG
2
ABL1_HUMAN
B:
[112-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
--
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------
492
Blastp_CBE
40.91
42%
-144
- C7 -
-
2HYY
1
ABL1_HUMAN
D:
[113-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
---------------------------------------------------------
455
Blastp_CBE
40.94
41%
-139
- C7 -
-
2QOH
1
ABL1_MOUSE
B:
[113-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
473
Blastp_CBE
40.93
41%
-146
- C7 -
-
1M52
1
ABL1_MOUSE
A:
[118-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
---------------------------------------------------------
479
Blastp_CBE
40.91
41%
-140
- C7 -
-
4WA9
1
ABL1_HUMAN
B:
[114-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
---------------------------------------------------
437
Blastp_CBE
40.86
45%
-150
- C7 -
-
4UEU
1
?
A:
[102-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
H
T
-----
V
-
N
----
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
N
V
V
K
V
A
D
F
G
L
A
R
-
L
I
----------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
-
M
S
G
S
E
-------
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
----
H
A
L
E
-------------------------------------------------------------
528
Blastp_CBE
40.82
41%
-141
- C7 -
-
2G2F
1
ABL1_HUMAN
B:
[115-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
---------------------------------------------------------
525
Blastp_CBE
40.80
41%
-154
- C7 -
-
2G2I
1
ABL1_HUMAN
A:
[115-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
---------------------------------------------------------
454
Blastp_CBE
40.77
41%
-139
- C7 -
-
3KF4
1
ABL1_MOUSE
A:
[113-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
508
Blastp_CBE
40.75
42%
-148
- C7 -
-
3QRK
1
ABL1_HUMAN
A:
[118-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
-----------------------------------------------------------
465
Blastp_CBE
40.71
41%
-147
- C7 -
-
3MS9
2
ABL1_MOUSE
B:
[118-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
-------------------------------------------------------------
530
Blastp_CBE
40.65
41%
-136
- C7 -
-
2F4J
1
ABL1_HUMAN
A:
[114-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
510
Blastp_CBE
40.70
42%
-145
- C7 -
-
3QRI
1
ABL1_HUMAN
A:
[118-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
---------------------------------------------------------
521
Blastp_CBE
40.64
42%
-147
- C7 -
-
3QRJ
1
ABL1_HUMAN
A:
[118-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
-----------------------------------------------------------
511
Blastp_CBE
40.64
42%
-136
- C7 -
-
3CS9
1
ABL1_HUMAN
D:
[117-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------
506
Blastp_CBE
40.65
41%
-150
- C7 -
-
2G1T
1
ABL1_HUMAN
B:
[115-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
---------------------------------------------------------
500
Blastp_CBE
40.64
41%
-146
- C7 -
-
4YC8
3
ABL1_HUMAN
B:
[115-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
---------------------------------------------------------
509
Blastp_CBE
40.57
42%
-145
- C7 -
-
3QRI
1
ABL1_HUMAN
B:
[118-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
---------------------------------------------------------
456
Blastp_CBE
40.50
41%
-142
- C7 -
-
2QOH
1
ABL1_MOUSE
A:
[113-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
----------------------------------------------------------
520
Blastp_CBE
40.39
42%
-142
- C7 -
-
3QRJ
1
ABL1_HUMAN
B:
[118-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
----------------------------------------------------------
313
Blastp_CBE
40.39
38%
-55
- C7 -
-
5FM2
1
A:
[52-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
E
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
-------------
N
V
L
K
Q
V
N
-
H
---
P
H
V
I
K
L
Y
G
A
C
S
Q
D
--------------
G
P
L
---
L
L
I
V
E
Y
A
K
G
S
L
---------------
R
G
F
L
R
E
S
R
-------------------------------------
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
K
R
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
-
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------
493
Blastp_CBE
40.28
42%
-145
- C7 -
-
2HYY
1
ABL1_HUMAN
C:
[113-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
---
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
---------------------------------------------------------
484
Blastp_CBE
40.28
41%
-145
- C7 -
-
4ZOG
5
ABL1_HUMAN
A:
[112-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
----------------------------------------------------------
487
Blastp_CBE
40.27
41%
-136
- C7 -
-
2Z60
1
ABL1_MOUSE
A:
[113-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
497
Blastp_CBE
40.26
41%
-143
- C7 -
-
2HIW
1
ABL1_HUMAN
A:
[115-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
------------------------------------------------------------
494
Blastp_CBE
40.24
42%
-137
- C7 -
-
2HYY
1
ABL1_HUMAN
B:
[113-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
---------------------------------------------------------
534
Blastp_CBE
40.15
41%
-141
- C7 -
-
6NPU
2
ABL1_HUMAN
A:
[126-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
-----------------------------------------------------------
532
Blastp_CBE
40.15
41%
-137
- C7 -
-
6NPV
2
ABL1_HUMAN
A:
[126-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
-----------------------------------------------------------
503
Blastp_CBE
40.14
41%
-143
- C7 -
-
3UE4
1
ABL1_HUMAN
A:
[115-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
---------------------------------------------------------
501
Blastp_CBE
40.13
41%
-142
- C7 -
-
4YC8
3
ABL1_HUMAN
A:
[115-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
----------------------------------------------------------
538
Blastp_CBE
40.08
41%
-142
- C7 -
-
3PYY
1
ABL1_HUMAN
A:
[126-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
-----------------------------------------------------------
463
Blastp_CBE
39.99
41%
-146
- C7 -
-
3MSS
2
ABL1_MOUSE
B:
[118-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
-------------------------------------------------------------
536
Blastp_CBE
40.02
41%
-141
- C7 -
-
6NPE
2
ABL1_HUMAN
A:
[126-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
-----------------------------------------------------------
527
Blastp_CBE
40.01
41%
-134
- C7 -
-
2G2H
1
ABL1_HUMAN
A:
[115-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------
453
Blastp_CBE
39.99
41%
-143
- C7 -
-
3KF4
1
ABL1_MOUSE
B:
[113-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
----------------------------------------------------------
512
Blastp_CBE
39.92
42%
-153
- C7 -
-
3CS9
1
ABL1_HUMAN
C:
[117-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
-------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
----------------------------------------------------------
475
Blastp_CBE
39.92
41%
-144
- C7 -
-
1IEP
1
ABL1_MOUSE
A:
[118-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
-------------------------------------------------------------
477
Blastp_CBE
39.87
41%
-139
- C7 -
-
1FPU
1
ABL1_MOUSE
A:
[118-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
------------------------------------------------------------
449
Blastp_CBE
39.86
45%
-144
- C7 -
-
2XYN
3
ABL2_HUMAN
B:
[132-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------------------------------------------------------------
524
Blastp_CBE
39.82
41%
-144
- C7 -
-
2G2I
1
ABL1_HUMAN
B:
[115-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
-----------------------------------------------------------
461
Blastp_CBE
39.80
41%
-146
- C7 -
-
3MSS
2
ABL1_MOUSE
D:
[118-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
-------------------------------------------------------------
505
Blastp_CBE
39.74
41%
-137
- C7 -
-
2G1T
1
ABL1_HUMAN
C:
[115-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
----------------------------------------------------
495
Blastp_CBE
39.74
42%
-141
- C7 -
-
2HYY
1
ABL1_HUMAN
A:
[113-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
---------------------------------------------------------
537
Blastp_CBE
39.72
41%
-145
- C7 -
-
3PYY
3
ABL1_HUMAN
B:
[126-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
513
Blastp_CBE
39.77
42%
-155
- C7 -
-
3CS9
1
ABL1_HUMAN
B:
[117-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
-------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------
452
Blastp_CBE
39.76
41%
-125
- C7 -
-
3KFA
1
ABL1_MOUSE
A:
[113-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
448
Blastp_CBE
39.74
45%
-145
- C7 -
-
2XYN
3
ABL2_HUMAN
C:
[132-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------------------------------------------------------------
450
Blastp_CBE
39.73
45%
-146
- C7 -
-
2XYN
2
ABL2_HUMAN
A:
[132-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------------------------------------------------------------
486
Blastp_CBE
39.72
41%
-138
- C7 -
-
3IK3
1
ABL1_MOUSE
A:
[113-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
464
Blastp_CBE
39.63
41%
-141
- C7 -
-
3MSS
2
ABL1_MOUSE
A:
[118-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
-------------------------------------------------------------
312
Blastp_CBE
39.59
38%
-51
- C7 -
-
5FM3
1
A:
[49-353]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
F
--
K
I
L
E
D
-
P
----------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
----------
V
K
A
T
A
F
H
L
--
K
-
G
R
--
A
--
G
Y
--
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
-------------
N
V
L
K
Q
V
N
-
H
---
P
H
V
I
K
L
Y
G
A
C
S
Q
D
--------------
G
P
L
---
L
L
I
V
E
Y
A
K
G
S
L
---------------
R
G
F
L
R
E
S
R
-------------------------------------
L
-
T
----
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
K
R
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
-
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
-
P
P
E
R
-------
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
----
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------
451
Blastp_CBE
39.58
41%
-125
- C7 -
-
3KFA
1
ABL1_MOUSE
B:
[113-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
535
Blastp_CBE
39.56
41%
-146
- C7 -
-
6NPE
3
ABL1_HUMAN
B:
[126-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
478
Blastp_CBE
39.55
41%
-135
- C7 -
-
3OXZ
1
ABL1_MOUSE
A:
[113-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
-----------
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
504
Blastp_CBE
39.53
41%
-144
- C7 -
-
2G1T
1
ABL1_HUMAN
D:
[115-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
---------------------------------------------------------
481
Blastp_CBE
39.52
41%
-142
- C7 -
-
2E2B
1
ABL1_HUMAN
B:
[118-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
--------------------------------------------------------------
533
Blastp_CBE
39.51
41%
-143
- C7 -
-
6NPU
5
ABL1_HUMAN
B:
[126-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
531
Blastp_CBE
39.45
41%
-143
- C7 -
-
6NPV
5
ABL1_HUMAN
B:
[126-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
507
Blastp_CBE
39.50
41%
-144
- C7 -
-
2G1T
1
ABL1_HUMAN
A:
[115-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
---------------------------------------------------------
529
Blastp_CBE
39.45
41%
-137
- C7 -
-
2G2F
1
ABL1_HUMAN
A:
[115-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
-----------------------------------------------------
476
Blastp_CBE
39.39
41%
-141
- C7 -
-
1FPU
1
ABL1_MOUSE
B:
[118-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
------------------------------------------------------------
498
Blastp_CBE
39.29
41%
-126
* C7 *
-
3OY3
1
ABL1_MOUSE
B:
[113-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
474
Blastp_CBE
39.26
41%
-135
- C7 -
-
1IEP
1
ABL1_MOUSE
B:
[118-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
-------------------------------------------------------------
499
Blastp_CBE
39.23
41%
-123
- C7 -
-
3OY3
1
ABL1_MOUSE
A:
[113-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
517
Blastp_CBE
39.19
42%
-137
- C7 -
-
5HU9
9
ABL1_HUMAN
A:
[117-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
---------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
----
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------
462
Blastp_CBE
39.13
41%
-141
- C7 -
-
3MSS
2
ABL1_MOUSE
C:
[118-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
-------------------------------------------------------------
444
Blastp_CBE
39.13
45%
-146
- C7 -
-
4XLI
1
B:
[108-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------------------------------------------------------------
485
Blastp_CBE
39.12
41%
-126
- C7 -
-
3IK3
1
ABL1_MOUSE
B:
[113-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
470
Blastp_CBE
39.10
41%
-129
- C7 -
-
1OPJ
2
ABL1_MOUSE
B:
[118-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
482
Blastp_CBE
39.05
41%
-132
- C7 -
-
2E2B
1
ABL1_HUMAN
A:
[118-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
----
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
---------------------------------------------------------
468
Blastp_CBE
39.04
41%
-130
- C7 -
-
3K5V
2
ABL1_MOUSE
A:
[118-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
458
Blastp_CBE
39.02
41%
-130
- C7 -
-
6HD6
2
ABL1_MOUSE
A:
[118-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
445
Blastp_CBE
39.01
45%
-144
- C7 -
-
4XLI
1
ABL2_MOUSE
A:
[108-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------------------------------------------------------------
446
Blastp_CBE
38.94
45%
-136
- C7 -
-
3HMI
1
ABL2_HUMAN
A:
[132-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------------------------------------------------------------
460
Blastp_CBE
38.91
41%
-132
- C7 -
-
6HD4
3
ABL1_MOUSE
A:
[118-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
469
Blastp_CBE
38.83
41%
-128
- C7 -
-
2HZN
1
ABL1_MOUSE
A:
[118-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
----------------------------------------------------------
466
Blastp_CBE
38.65
41%
-136
- C7 -
-
3MS9
2
ABL1_MOUSE
A:
[118-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
--
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
-------------------------------------------------------------
496
Blastp_CBE
38.53
41%
-133
- C7 -
-
2HIW
1
ABL1_HUMAN
B:
[115-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
------------------------------------------------------------
447
Blastp_CBE
38.09
45%
-137
- C7 -
-
3GVU
2
ABL2_HUMAN
A:
[132-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
V
V
K
V
A
D
F
G
L
S
R
----
G
D
T
Y
T
----
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
-----------------------------------------------------------------------
471
Blastp_CBE
38.01
41%
-125
- C7 -
-
1OPJ
2
ABL1_MOUSE
A:
[118-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
459
Blastp_CBE
37.82
41%
-129
- C7 -
-
6HD4
2
ABL1_MOUSE
B:
[118-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
467
Blastp_CBE
37.78
41%
-128
- C7 -
-
3K5V
2
ABL1_MOUSE
B:
[118-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
457
Blastp_CBE
37.43
41%
-127
- C7 -
-
6HD6
1
ABL1_MOUSE
B:
[118-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
-------
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
QAFE
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
--------------------------------------------------
439
Blastp_CBE
34.61
39%
-32
- C7 -
-
3ETA
1
B:
[80-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
LRP
E
A
E
N
N
P
G
R
P
-----
P
P
T
----
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
-------
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
----
N
L
L
K
D
------------------------------------------------------------
440
Blastp_CBE
33.47
39%
-31
- C7 -
-
3ETA
1
INSR_HUMAN
A:
[80-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
LRP
E
A
E
N
N
P
G
R
P
-----
P
P
T
----
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
-
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
-------
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
----
N
L
L
K
D
------------------------------------------------------------
101
Blastp_CBE
33.15
45%
12
- C7 -
-
3CJG
1
A:
[11-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HCERLPYDAS
K
W
E
F
P
R
D
R
L
N
L
G
K
P
L
G
R
---
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
-----
A
T
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
--------------------------------------
S
T
Y
L
R
--------------------
S
K
R
N
E
F
V
P
Y
K
---
D
L
Y
K
D
F
--------
L
-
T
----
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
--------------
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
----
E
H
L
--------------------------------------------------------------
293
Blastp_CBE
31.41
43%
18
- C7 -
-
3CJF
1
A:
[12-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CERLPYDAS-
K
W
E
F
P
R
D
R
L
N
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
-----
A
T
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
------------------------------------
L
G
A
C
---
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
--------------------
S
K
R
N
E
F
V
P
Y
K
---
D
---
D
F
--------
L
-
T
----
L
E
H
L
I
-
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
-
D
F
G
-
A
R
D
I
Y
K
D
P
D
------------
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
R
R
L
C
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
----
E
H
L
--------------------------------------------------------------
294
Blastp_CBE
31.31
42%
26
- C7 -
-
3C7Q
1
A:
[16-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLPYDAS---
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
----------
I
E
A
D
A
F
G
I
--
D
-
K
T
-----
A
T
--
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
------------------------------------
L
G
A
C
---
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
-------
N
E
F
V
P
Y
--------------------
K
D
F
--------
L
-
T
----
L
E
H
L
I
-
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
---
K
N
V
V
K
I
C
D
F
G
L
A
R
D
---
P
D
--
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
-------
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
EHLG
N
L
L
Q
A
N
A
Q
Q
D
-------------------------------------------------------
546
Blastp_CBE
28.72
39%
-22
- C7 -
-
1RQQ
1
B:
[81-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
LRP
E
A
E
N
N
P
G
R
P
-----
P
P
T
----
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
R
K
Y
--
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
-------
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
----
N
L
L
K
D
------------------------------------------------------------
547
Blastp_CBE
28.02
39%
-23
- C7 -
-
1RQQ
1
INSR_HUMAN
A:
[81-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
LRP
E
A
E
N
N
P
G
R
P
-----
P
P
T
----
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
R
K
Y
--
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
-------
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
----
N
L
L
K
D
------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------