@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DCLK1_HUMAN: (2021-11-22 )
MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
Atome Classification :
(341 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380..-.---..---..390-..-..-...400.......410.......420-------...-..----.-------.-.--430---.----.-----...-------....440.-.-.-....450.......460--..-------.......470.-.....--.--480----.---.......490.......500.......510.......520.......530.....--.------.-----540-.--.---.---..-.-...550......---.------560----...-----.-.....570.......580.......-590--.-------.-..-----...600.......610..-.....620.......630....----...640---......-.-..650------........660.......670.......680.......690.......700.......710.......720.......730.......740
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSFGRDM
E
L
E
HFD
E
R
D
K
A
Q
R
YSRGSRVNGLPSPTHSA
H
C
S
F
Y
R
T
R
T
L
Q
T
L
S
SEKKA
K
K
V
R
F
Y
RNGD
R
Y
F
K
G
I
V
Y
A
I
S
P
D
R
F
R
S
F
E
A
L
L
A
D
L
T
R
T
L
SDNVNLPQG
V
R
T
I
Y
T
I
D
G
L
K
K
I
S
S
L
D
Q
L
VEGE
S
Y
VCGSI
E
P
F
K
K
L
E
YTKNVNP
N
W
S
V
N
V
K
TT
S
A
S
R
A
V
S
S
L
ATAKG
S
P
S
E
V
R
ENKDF
I
R
P
K
L
V
T
I
I
R
SGV
K
P
R
K
A
V
R
I
L
LNKK
T
A
H
S
F
E
Q
V
L
T
D
I
T
D
A
I
KL
D
S
G
V
V
K
R
L
YTLDG
K
Q
V
M
C
L
Q
D
FFGDD
D
I
F
I
A
CGPEKFRYQDDFLLDESE
C
R
V
V
KSTS
Y
T
K
IASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTS
P
G
S
L
R
K
Q
R
SSQHGGSSTSL
A
S
T
K
V
CSSMDENDGPG
E
E
V
S
EEGFQI
P
A
-
T
---
I
T
---
E
R
YKV-G
R
-
T
I-GD
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------
K
KS-KC----R-------
G
-
K
--
E
-----
H
----
M
-----
I
Q
N
-------
E
V
S
I
L
R
RV-K-H-P
N
I
V
L
L
I
EEMDV
P
T
E
----
L
Y
-------
L
V
M
E
L
VKGG
D
L
-
F
D
A
I
T--S--T-N----K---YTERDAS
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
HRDIKPE
N
L
L
V
Y
EHQDGSKSLKLGDFG
L
A
--
T
------I-----V---D--G---P---
L
Y
-
T
-VCGTPTY
V
A
P
E
I
---
I
------A------ETG-----Y-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
LCGFPPFRG-SGD--
D
-------
Q
-
E
V
-----
L
F
D
Q
I
L
MGQVDFPSPYWD-NV
S
D
S
A
K
E
L
I
T
M
M
L
L
VD
V
D
Q
R
F
----
S
A
V
Q
-----
V
L
EHPW-V-NDDG-------LPEN
E
H
Q
L
S
V
A
G
K
I
K
K
H
FNTGPKPNSTAA
G
V
S
V
I
A
TTAL
D
K
E
R
Q
V
F
R
R
RR
N
Q
D
V
R
S
RYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
2
PsiBlast_PDB
90.84
99%
-133
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[10-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
Q
I
P
A
-
T
---
I
T
---
E
R
Y
K
V
-
G
R
-
T
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------
K
K
S
-
K
C
----
R
-------
G
-
K
--
E
-----
H
----
M
-----
I
Q
N
-------
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
-------
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
--
S
--
T
-
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
------
I
-----
V
---
D
--
G
---
P
---
L
Y
-
T
-
V
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
------
E
T
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
-
S
----
D
-------
Q
-
E
V
-----
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
----
S
A
V
Q
-----
V
L
E
H
P
W
-
V
-
N
---------------------------------------------------------------------------------------------------
590
HHSearch
90.37
100%
-131
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[12-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
P
A
-
T
---
I
T
---
E
R
Y
K
V
-
G
R
-
T
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------
K
K
S
-
K
C
----
R
-------
G
-
K
--
E
-----
H
----
M
-----
I
Q
N
-------
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
-------
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
--
S
--
T
-
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
------
I
-----
V
---
D
--
G
---
P
---
L
Y
-
T
-
V
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
------
E
T
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
-
S
----
D
-------
Q
-
E
V
-----
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
----
S
A
V
Q
-----
V
L
E
H
P
W
-
V
-
N
---------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.70
99%
-128
- C1 -
-
5JZJ
2
DCLK1_HUMAN
A:
[22-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
E
E
G
F
Q
I
P
A
-
T
---
I
T
---
E
R
Y
K
V
-
G
R
-
T
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------
K
K
S
-
K
C
----
R
-------
G
-
K
--
E
-----
H
----
M
-----
I
Q
N
-------
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
-------
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
--
S
--
T
-
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
------
I
-----
V
---
D
--
G
---
P
---
L
Y
-
T
-
V
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
------
E
T
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
-
S
--------------
E
V
-----
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
----
S
A
V
Q
-----
V
L
E
H
P
W
-
V
-
N
---------------------------------------------------------------------------------------------------
22
Blastp_CBE
88.82
99%
-131
- C1 -
-
5JZN
1
B:
[11-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
I
P
A
-
T
---
I
T
---
E
R
Y
K
V
-
G
R
-
T
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------
K
K
S
-
K
C
----
R
-------
G
-
K
--
E
-----
H
----
M
-----
I
Q
N
-------
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
-------
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
--
S
--
T
-
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
------
I
-----
V
---
D
--
G
---
P
---
L
Y
-
T
-
V
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
------
E
T
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
-
S
------------
Q
-
E
V
-----
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
----
S
A
V
Q
-----
V
L
E
H
P
W
-
V
-
N
---------------------------------------------------------------------------------------------------
591
HHSearch
87.41
100%
-136
- C1 -
-
5JZJ
1
B:
[30-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
A
-
T
---
I
T
---
E
R
Y
K
V
-
G
R
-
T
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------
K
K
S
-
K
C
----
R
-------
G
-
K
--
E
-----
H
----
M
-----
I
Q
N
-------
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
-------
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
--
S
--
T
-
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
------
I
-----
V
---
D
--
G
---
P
---
L
Y
-
T
-
V
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
------
E
T
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
-----------------
E
V
-----
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
----
S
A
V
Q
-----
V
L
E
H
P
W
-
V
-
N
---------------------------------------------------------------------------------------------------
21
Blastp_CBE
87.19
99%
-136
- C1 -
-
5JZJ
1
B:
[30-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
A
-
T
---
I
T
---
E
R
Y
K
V
-
G
R
-
T
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------
K
K
S
-
K
C
----
R
-------
G
-
K
--
E
-----
H
----
M
-----
I
Q
N
-------
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
-------
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
--
S
--
T
-
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
------
I
-----
V
---
D
--
G
---
P
---
L
Y
-
T
-
V
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
------
E
T
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
-----------------
E
V
-----
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
----
S
A
V
Q
-----
V
L
E
H
P
W
-
V
-
N
---------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.57
46%
-140
- C1 -
-
4FG8
1
KCC1A_HUMAN
A:
[16-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
---
D
I
Y
D
F
-
R
D
-
V
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--------
A
K
E
---------------------------------------
N
-------
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
--
E
--
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
-----------------------------------------
T
P
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
--
A
-------
K
--------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
-----
A
L
Q
H
P
W
-
I
A
G
D
T
A
-------
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
-----------------------------------------------------------------------
5
PsiBlast_PDB
73.38
46%
-139
- C1 -
-
4FG9
1
KCC1A_HUMAN
A:
[16-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
---
D
I
Y
D
F
-
R
D
-
V
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--------
A
K
E
--------------------------------------
E
N
-------
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
--
E
--
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
------------------------------------------
P
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
--
A
-------
K
--------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
-----
A
L
Q
H
P
W
-
I
A
G
D
T
A
-------
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
-----------------------------------------------------------------------
7
PsiBlast_PDB
72.96
46%
-137
- C1 -
-
1A06
-
KCC1A_RAT
A:
[16-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
---
D
I
Y
D
F
-
R
D
-
V
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--------
A
K
---------------------------------------
E
N
-------
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
--
E
--
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
------------------------------------------
P
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
--
A
-------
K
--------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
-----
A
L
Q
H
P
W
-
I
A
G
D
T
A
-------
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
-----------------------------------------------------------------------
24
Blastp_CBE
72.88
46%
-141
- C1 -
-
4FG9
1
KCC1A_HUMAN
B:
[16-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
---
D
I
Y
D
F
-
R
D
-
V
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--------
A
K
E
------------------------------------------------
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
--
E
--
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
-----------------------------
V
---
L
S
-
T
-
A
C
G
T
P
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
--
A
-------
K
--------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
-----
A
L
Q
H
P
W
-
I
A
G
D
T
A
-------
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
-----------------------------------------------------------------------
4
PsiBlast_PDB
71.52
44%
-141
- C1 -
-
2JC6
1
KCC1D_HUMAN
A:
[20-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
---
K
I
F
E
F
-
K
E
-
T
L
-
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
--------
P
K
K
-
A
------------------------
S
----
S
-----
I
E
N
-------
E
I
A
V
L
R
K
I
-
K
-
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
-------
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
--
E
--
K
-
G
----
F
---
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-
Q
D
E
E
S
K
I
M
I
S
--------------------------------------------
P
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
--
S
-------
K
--------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
----
T
C
E
Q
-----
A
A
R
H
P
W
-
I
A
G
D
T
A
-------
L
N
K
N
I
H
E
-
S
V
S
A
Q
I
R
K
N
F
-----------------------------------------------------------------------
25
Blastp_CBE
71.28
45%
-140
- C1 -
-
2JC6
1
KCC1D_HUMAN
C:
[20-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
---
K
I
F
E
F
-
K
E
-
T
L
-
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
--------
P
K
K
-
A
-----------------------------
S
-----
I
E
N
-------
E
I
A
V
L
R
K
I
-
K
-
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
-------
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
--
E
--
K
-
G
----
F
---
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-
Q
D
E
E
S
K
I
M
I
S
--------------------------------------------
P
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
--
S
-------
K
--------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
----
T
C
E
Q
-----
A
A
R
H
P
W
-
I
A
G
D
T
A
-------
L
N
K
N
I
H
E
-
S
V
S
A
Q
I
R
K
N
F
-----------------------------------------------------------------------
23
Blastp_CBE
69.44
46%
-88
- C1 -
-
4FG8
1
KCC1A_HUMAN
B:
[16-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
---
D
I
Y
D
F
-
R
D
-
V
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--------
A
K
----------------------------------------
N
-------
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
--
E
--
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
G
----------------------G-
S
---
V
---
L
S
-
T
-
A
C
G
T
P
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
--
A
-------
K
--------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
-----
A
L
Q
H
P
W
-
I
A
G
D
T
A
-------
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
-----------------------------------------------------------------------
390
Blastp_CBE
69.39
35%
-151
- C1 -
-
4BKY
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
--------------
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
-----------------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
378
Blastp_CBE
69.33
35%
-155
- C1 -
-
5TWY
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
---------------
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
-------------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.05
42%
-95
- C1 -
-
2JAM
3
KCC1G_HUMAN
A:
[7-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
---
K
T
F
I
F
-
M
E
-
V
L
-
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--------
K
K
---------------------------
S
----
S
-----
L
E
N
-------
E
I
A
V
L
K
K
I
-
K
-
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
-------
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
L
--
E
--
R
-
G
----
V
---
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
-
I
M
I
T
D
F
G
L
S
--
K
------
M
E----
Q
---
N
--
G
---
I
---
M
S
-
T
-
A
C
G
T
P
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
E
--
S
-------
K
--------
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
----
T
C
E
K
-----
A
L
S
H
P
W
-
I
-
D
G
N
T
-------
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
-----------------------------------------------------------------------
28
Blastp_CBE
68.98
42%
-97
- C1 -
-
2JAM
3
KCC1G_HUMAN
B:
[7-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
---
K
T
F
I
F
-
M
E
-
V
L
-
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--------
K
K
---------------------------
S
----
S
-----
L
E
N
-------
E
I
A
V
L
K
K
I
-
K
-
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
-------
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
L
--
E
--
R
-
G
----
V
---
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
-
I
M
I
T
D
F
G
L
S
--
K
------
M
E----
Q
---
N
--
G
---
I
---
M
S
-
T
-
A
C
G
T
P
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
-
E
T
E
--
S
-------
K
--------
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
----
T
C
E
K
-----
A
L
S
H
P
W
-
I
-
D
G
N
T
-------
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
-----------------------------------------------------------------------
467
Blastp_CBE
68.64
35%
-144
- C1 -
-
4D2P
2
MELK_HUMAN
A:
[27-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
---------------
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
----------------------------------
G
A
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
T
-------
A
-
A
A
-----
L
V
A
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
472
Blastp_CBE
68.44
34%
-145
- C1 -
-
4BFM
1
MELK_MOUSE
A:
[7-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
Y
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
A
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
V
K
T
-------
E
I
D
A
L
K
S
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
E
N
H
K
L
K
L
I
D
F
G
L
C
--
A
------
K
--------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
----------------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
E
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
R
N
-----
L
L
N
H
P
W
-
V
-
M
Q
D
-------------------------------------------------------------------------------------------------
455
Blastp_CBE
68.42
35%
-153
- C1 -
-
4D2W
1
MELK_HUMAN
A:
[27-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
---------------
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
---------------------------------
C
G
A
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
T
-------
A
-
A
A
-----
L
V
A
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
389
Blastp_CBE
68.41
35%
-158
- C1 -
-
4BKZ
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
-----------------
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
-----------------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
---------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
445
Blastp_CBE
68.37
35%
-127
- C1 -
-
4UMR
1
MELK_HUMAN
A:
[27-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
-------------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
T
-------
A
-
A
A
-----
L
V
A
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
473
Blastp_CBE
68.22
34%
-146
- C1 -
-
4CQG
1
MELK_MOUSE
A:
[7-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
Y
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
A
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
V
K
T
-------
E
I
D
A
L
K
S
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
E
N
H
K
L
K
L
I
D
F
G
L
C
--
A
------
K
--------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
----------------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
E
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
R
N
-----
L
L
N
H
P
W
-
V
-
M
Q
D
-------------------------------------------------------------------------------------------------
446
Blastp_CBE
68.19
35%
-124
- C1 -
-
4UMQ
1
MELK_HUMAN
A:
[27-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
-------------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
T
-------
A
-
A
A
-----
L
V
A
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.85
46%
-114
- C1 -
-
4FG7
1
KCC1A_HUMAN
A:
[16-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
---
D
I
Y
D
F
-
R
D
-
V
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--------
A
---------------------------------
S
-----
M
E
N
-------
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
-------
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
--
E
--
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
G
L
S
--
K
------
M
-----
E
---
D
P----------------
G
T
P
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
--------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
-
E
N
D
--
A
-------
K
--------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
-----
A
L
Q
H
P
W
-
I
A----------------------------------------------------------------------------------------------------
379
Blastp_CBE
67.76
35%
-120
- C1 -
-
5TWL
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
-------------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
388
Blastp_CBE
67.23
35%
-152
- C1 -
-
4BL1
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
-----------------
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
----------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
384
Blastp_CBE
67.19
35%
-123
- C1 -
-
5MAH
2
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
----------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
-------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
377
Blastp_CBE
67.17
35%
-157
- C1 -
-
5TWY
1
MELK_HUMAN
B:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-----------------
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---------------------------------------
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
387
Blastp_CBE
67.16
35%
-121
- C1 -
-
5M5A
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
-----------------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
-------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
425
Blastp_CBE
67.11
35%
-124
- C1 -
-
4UMU
1
MELK_HUMAN
A:
[27-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
-------------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
T
-------
A
-
A
A
-----
L
V
A
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
376
Blastp_CBE
67.07
35%
-124
- C1 -
-
5TWZ
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
---------------------------------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
375
Blastp_CBE
66.94
35%
-159
- C1 -
-
5TX3
2
MELK_HUMAN
A:
[11-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-------------------------------------
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
--------------------------------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
30
Blastp_CBE
66.94
43%
-61
- C1 -
-
3BHH
1
KCC2B_HUMAN
B:
[2-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
---
D
E
Y
Q
L
-
Y
E
-
D
I
-
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
E
A
-----
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
K
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
----
T
A
H
E
-----
A
L
K
H
P
W
-
V
-----------------------------------------------------------------------------------------------------
409
Blastp_CBE
66.91
35%
-128
- C1 -
-
5IHC
1
MELK_HUMAN
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
----------------------------------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
426
Blastp_CBE
66.90
35%
-128
- C1 -
-
4UMT
2
MELK_HUMAN
A:
[27-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
-------------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
T
-------
A
-
A
A
-----
L
V
A
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
411
Blastp_CBE
66.85
35%
-120
- C1 -
-
5IH9
1
MELK_HUMAN
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
------------------
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
----------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
386
Blastp_CBE
66.85
35%
-120
- C1 -
-
5MAF
2
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
--------------
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
----------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
-------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
36
Blastp_CBE
66.56
42%
-49
- C1 -
-
6BAB
2
KCC2D_MOUSE
C:
[14-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
398
Blastp_CBE
66.47
35%
-118
* C1 *
-
5TVT
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
---------------------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
408
Blastp_CBE
66.32
35%
-119
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
-----
P
----------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
40
Blastp_CBE
66.29
42%
-51
- C1 -
-
6AYW
2
KCC2D_HUMAN
A:
[11-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
66.10
43%
-60
- C1 -
-
3BHH
1
KCC2B_HUMAN
A:
[1-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
---
D
E
Y
Q
L
-
Y
E
-
D
I
-
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
E
A
-----
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
K
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
----
T
A
H
E
-----
A
L
K
H
P
W
-
V
-----------------------------------------------------------------------------------------------------
385
Blastp_CBE
65.95
35%
-119
- C1 -
-
5MAG
3
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
--------------
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
----------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
-------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
383
Blastp_CBE
65.95
35%
-126
- C1 -
-
5MAI
2
MELK_HUMAN
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----
G
-------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
-----------------------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
412
Blastp_CBE
65.86
35%
-122
- C1 -
-
5IH8
1
MELK_HUMAN
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
---------------
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
----------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
39
Blastp_CBE
65.70
42%
-49
- C1 -
-
6AYW
2
KCC2D_HUMAN
B:
[11-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.60
42%
-48
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[1-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
---
D
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
41
Blastp_CBE
65.55
42%
-49
- C1 -
-
5VLO
2
KCC2D_HUMAN
B:
[11-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
391
Blastp_CBE
65.44
35%
-141
- C1 -
-
6GVX
2
MELK_HUMAN
B:
[11-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
-------------
S
-
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
-----
P
---------------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
---------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
595
HHSearch
65.41
41%
-44
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
---
D
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
A------
R
-
D
--
H
-----
Q
----
K
-----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
K
G
A
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
---
D
QQA
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
-
E
D
Q
------------
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-
C
Q
R
S
-------
T
----------------------------------------------------------------------------------------
33
Blastp_CBE
65.26
42%
-53
- C1 -
-
2VN9
1
KCC2D_HUMAN
B:
[1-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
---
D
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
283
Blastp_CBE
65.24
39%
-73
- C1 -
-
4YUQ
1
?
B:
[26-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
A
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
--------
S
K
R
-
Q
-----------------------------------
L
L
K
-------
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
T
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
N
K
R
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
S
TK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
E
--
F
-------
D
--------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
----
S
A
R
D
-----
A
L
E
H
E
W
-
L
-----------------------------------------------------------------------------------------------------
38
Blastp_CBE
65.16
42%
-49
- C1 -
-
6BAB
2
KCC2D_MOUSE
A:
[12-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
---
D
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
65.16
41%
-62
- C1 -
-
3SOA
1
KCC2A_HUMAN
A:
[9-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
E
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
----
H
Y
-------
L
I
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
E
--
G
EQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
----
T
A
A
E
-----
A
L
K
H
P
W
-
I
-
S
---------------------------------------------------------------------------------------------------
220
Blastp_CBE
64.99
40%
-88
- C1 -
-
3F3Z
5
?
A:
[7-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
---
Q
Y
Y
T
L
-
E
N
-
T
I
-
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
--------
P
K
Y
-
F
V
----
E
-------
D
-
V
--
D
-----
R
----
F
-----
K
Q
--------
E
I
E
I
M
K
S
L
-
D
-
H
-
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
----
I
Y
-------
L
V
M
E
L
C
T
G
G
E
L
-
F
E
R
V
V
--
H
--
K
-
R
----
V
---
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
L
T
D
S
P
D
S
-
P
L
K
L
I
D
F
G
L
A
--
A
------
R
-----
F
---
K
PG
K
---
M
---
M
R
-
T
-
K
V
G
T
P
Y
Y
V
S
P
Q
V
---
L
-------------
E
G
L
-----
Y
-
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
-
P
T
D
--
S
---------
E
V
-----
M
L
-
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
-
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
----
T
S
L
Q
-----
A
L
E
H
E
W
-------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.86
41%
-114
- C1 -
-
2W4O
1
KCC4_HUMAN
A:
[50-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
L
S
---
D
F
F
E
V
-
E
S
-
E
L
-
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
--------
K
K
-------------------------------------------------
I
G
V
L
L
R
L
-
S
-
H
-
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
----
I
S
-------
L
V
L
E
L
V
T
G
G
E
L
-
F
D
R
I
V
--
E
--
K
-
G
----
Y
---
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
-
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
----------------------------------------
G
T
P
G
Y
C
A
P
E
I
---
L
------
R
------
G
C
A
-----
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
-
E
R
G
--
D
-------
Q
--
F
-----
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
-
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
----
T
T
F
Q
-----
A
L
Q
H
P
W
-
V
-
T
--
G
-------
K
A
A
N
F
V
H
M
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
--
A
A
V
K
A
V
V
A
S
S
----------------------------------------------------
20
PsiBlast_PDB
64.70
42%
-53
- C1 -
-
2VN9
2
KCC2D_HUMAN
A:
[1-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
---
D
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
42
Blastp_CBE
64.62
42%
-55
- C1 -
-
5VLO
2
KCC2D_HUMAN
A:
[11-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
E
Y
Q
L
-
F
E
-
E
L
-
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
410
Blastp_CBE
64.55
35%
-126
- C1 -
-
5IHA
1
MELK_HUMAN
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
----
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
L
----------------------------
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
----------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
392
Blastp_CBE
64.29
35%
-95
- C1 -
-
6GVX
3
MELK_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
T
--
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
N
-
T
---------------
D
--
L
-----
P
----
R
-----
I
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
--
A
------
K
-----
P
---
K
--
G
NK-----------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
287
Blastp_CBE
64.27
39%
-78
- C1 -
-
4YSJ
1
?
B:
[26-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
A
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
--------
S
K
R
-------------------------------------
L
L
K
-------
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
T
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
N
K
R
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
S
TK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
E
--
F
-------
D
--------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
----
S
A
R
D
-----
A
L
E
H
E
W
-
L
-----------------------------------------------------------------------------------------------------
284
Blastp_CBE
64.08
39%
-75
- C1 -
-
4YUQ
1
?
A:
[26-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
A
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
--------
S
K
R
-
Q
-----------------------------
L
-----
L
L
K
-------
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
T
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
N
K
R
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
S
TK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
E
--
F
-------
D
--------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
----
S
A
R
D
-----
A
L
E
H
E
W
-
L
-----------------------------------------------------------------------------------------------------
605
HHSearch
63.54
39%
-15
- C1 -
-
2Y7J
1
PHKG2_HUMAN
A:
[91-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
F
Y
---
Q
K
Y
D
P
-
K
D
-
V
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
--------
E
V
T
-
A
E
----
R
LSPEQLE
E
-
V
--
R
-----
E
----
A
-----
T
R
R
-------
E
T
H
I
L
R
Q
V
A
G
-
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
-------
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
L
T
--
E
--
K
-
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
--
C
------
H
-----
L
---
E
--
P
GE-
K
---
L
R
-
E
-
L
C
G
T
P
G
Y
L
A
P
E
I
---
L
------
K
CSMDET
H
P
G
-----
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
R
Q
------------
I
L
-----
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
----
T
A
E
Q
-----
A
L
Q
H
P
F
-
F
-
E
---------------------------------------------------------------------------------------------------
359
Blastp_CBE
63.28
36%
-119
- C1 -
-
5XZV
1
?
B:
[200-467]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
E
-
V
V
-
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
--------
S
K
R
-
K
------------------
M
-----
D
----
G
-----
V
T
R
-------
E
L
E
V
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
----
Y
Y
-------
M
V
M
E
F
V
S
G
G
D
L
-
M
D
F
V
A
--
A
--
H
-
G
----
A
---
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
--
E
Q
D
D
P
V
L
V
K
I
T
D
F
G
L
----------------------------------
T
-
F
C
G
T
L
A
Y
V
A
P
E
V
---
I
-------------
R
N
E
-----
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
-
S
T
Q
--
D
-------
Q
--------
L
Y
K
Q
I
G
R
G
S
Y
-
H
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
----
T
A
A
K
-----
A
L
N
H
P
W
-
I
-
V
---------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.27
43%
-9
- C1 -
-
2V7O
3
KCC2G_HUMAN
A:
[20-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
A
-
T
CTR
F
T
---
D
D
Y
Q
L
-
F
E
-
E
L
-
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
EQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
K
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
----
T
A
D
Q
-----
A
L
K
H
P
W
-
V
-----------------------------------------------------------------------------------------------------
261
Blastp_CBE
63.11
36%
-9
- C1 -
-
3MFR
1
CSKP_HUMAN
A:
[26-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
C
E
-
V
I
-
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--------
D
V
A
-
K
F
----
T
-------
S
-
S
--
P
-----
G
----
L
STED-
L
K
R
-------
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
--
A
-
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
-
A
S
K
E
N
S
A
P
V
K
L
G
D
F
G
V
A
--
I
QLGESG
L
-----
V
---
A
--
G
----------
G
-
R
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
------
R
E
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
------------
K
-
E
R
-----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
-----
A
L
N
H
P
W
-
L
-
K
E
R
D
RYAYKIH
L
P
E
T
V
E
Q
L
---------------------------------------------------------------------------------
51
Blastp_CBE
63.04
40%
-48
- C1 -
-
4JG8
1
A:
[33-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
G
Y
E
V
-
K
E
-
D
I
-
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
--------
D
K
S
-
K
R
----
D
-------
P
-
T
--
E
--------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
-------
V
V
M
E
L
M
K
G
G
E
L
-
L
D
K
I
L
--
R
--
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
------
Q
-----
L
RAE
N
--
G
---
L
---
L
M
-
T
-
P
C
Y
T
A
N
F
V
A
P
E
V
---
L
------
E
------
R
Q
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
-
G
P
D
--
D
-------
T
P
E
E
-----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
----
T
A
A
L
-----
V
L
R
H
P
W
I
V
-
H
W
D
Q
-------
L
P
Q
Y
Q
------------------------------------------------------------------------------------
162
Blastp_CBE
63.03
36%
-26
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[82-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
--
W
A
A
A
K
-
E
---
F
Y
---
Q
K
Y
D
P
-
K
D
-
V
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
--------
E
V
--------
R
-------
L
-
S
--
P
-----
E
----
Q
-----
L
E
E
VREATRR
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
-------
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
L
T
--
E
--
K
-
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
--
C
------
H
-----
L
---
E
PG
E
---
K
---
L
R
-
E
-
L
C
G
T
P
G
Y
L
A
P
E
I
---
L
KCSMDE
T
------
H
P
G
-----
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
----
R
-------
Q
-
I
L
-----
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
----
T
A
E
Q
-----
A
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------
163
Blastp_CBE
62.90
36%
-23
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[82-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
--
W
A
A
A
K
-
E
---
F
Y
---
Q
K
Y
D
P
-
K
D
-
V
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
--------
E
V
T
-
A
E
----
R
-------
L
-
S
--
P
-----
E
----
Q
-----
L
E
E
VREATRR
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
-------
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
L
T
--
E
--
K
-
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
--
C
------
H
-----
L
---
E
PG
E
---
K
---
L
R
-
E
-
L
C
G
T
P
G
Y
L
A
P
E
I
---
L
KCSMDE
T
------
H
P
G
-----
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
----
R
-------
Q
-
I
L
-----
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
----
T
A
E
Q
-----
A
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------
215
Blastp_CBE
62.78
38%
-47
- C1 -
-
3HX4
3
?
A:
[46-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
-------------------D-
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
291
Blastp_CBE
62.71
35%
-18
- C1 -
-
3C0H
1
CSKP_HUMAN
A:
[26-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
C
E
-
V
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--------
D
V
A
-
K
F
----
T
-------
S
-
S
--
P
-----
G
----
L
STED-
L
K
R
-------
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
--
A
-
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
-
A
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
QLGESG
L
-----
V
---
A
--
G
----------
G
-
R
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
------
R
E
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
------------
K
-
E
R
-----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
-----
A
L
N
H
P
W
-
L
-
K
E
R
D
RYAYKIH
L
P
E
T
V
E
Q
L
---------------------------------------------------------------------------------
37
Blastp_CBE
62.71
42%
-45
- C1 -
-
6BAB
2
KCC2D_MOUSE
B:
[14-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
Q
L
-
F
E
-
E
L
-
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
259
Blastp_CBE
62.50
36%
-12
- C1 -
-
3MFU
1
CSKP_HUMAN
A:
[26-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
C
E
-
V
I
-
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--------
D
V
A
-
K
F
----
T
-------
S
-
S
--
P
-----
G
----
L
STED-
L
K
R
-------
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
--
A
-
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
-
A
S
K
E
N
S
A
P
V
K
L
G
D
F
G
V
A
--
I
QLGESG
L
-----
V
---
A
--
G
----------
G
-
R
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
------
R
E
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
------------
K
-
E
R
-----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
-----
A
L
N
H
P
W
-
L
-
K
E
R
D
RYAYKIH
L
P
E
T
V
E
Q
L
---------------------------------------------------------------------------------
293
Blastp_CBE
62.49
35%
-13
- C1 -
-
3C0G
1
CSKP_HUMAN
A:
[26-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
C
E
-
V
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--------
D
V
A
-
K
F
----
T
-------
S
-
S
--
P
-----
G
----
L
STED-
L
K
R
-------
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
--
A
-
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
-
A
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
QLGESG
L
-----
V
---
A
--
G
----------
G
-
R
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
------
R
E
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
------------
K
-
E
R
-----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
-----
A
L
N
H
P
W
-
L
-
K
E
R
D
RYAYKIH
L
P
E
T
V
E
Q
L
---------------------------------------------------------------------------------
165
Blastp_CBE
62.41
36%
-20
- C1 -
-
2Y7J
1
PHKG2_HUMAN
A:
[82-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
--
W
A
A
A
K
-
E
---
F
Y
---
Q
K
Y
D
P
-
K
D
-
V
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
--------
E
V
T
-
A
E
----
R
-------
L
-
S
--
P
-----
E
----
Q
-----
L
E
E
VREATRR
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
-------
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
L
T
--
E
--
K
-
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
--
C
------
H
-----
L
---
E
PG
E
---
K
---
L
R
-
E
-
L
C
G
T
P
G
Y
L
A
P
E
I
---
L
KCSMDE
T
------
H
P
G
-----
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
----
R
-------
Q
-
I
L
-----
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
----
T
A
E
Q
-----
A
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------
374
Blastp_CBE
62.37
35%
-126
- C1 -
-
5TX3
2
MELK_HUMAN
B:
[11-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
Y
Y
E
L
-
H
E
-
T
I
-
G
-----
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
--------
D
K
---------------------------------------
K
T
-------
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
-------
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
--
S
--
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
-----------------------------------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
------
G
--------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
--
N
-------
V
-
M
A
-----
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
-----
L
L
N
H
P
W
-
I
-
M
Q
D
-------------------------------------------------------------------------------------------------
290
Blastp_CBE
62.17
35%
-20
- C1 -
-
3C0H
1
CSKP_HUMAN
B:
[26-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
C
E
-
V
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--------
D
V
A
-
K
F
----
T
-------
S
-
S
--
P
-----
G
----
L
STED-
L
K
R
-------
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
--
A
-
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
-
A
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
QLGESG
L
-----
V
---
A
--
G
----------
G
-
R
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
------
R
E
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
------------
K
-
E
R
-----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
-----
A
L
N
H
P
W
-
L
-
K
E
R
D
RYAYKIH
L
P
E
T
V
E
Q
L
---------------------------------------------------------------------------------
164
Blastp_CBE
62.17
36%
-22
- C1 -
-
2Y7J
1
PHKG2_HUMAN
B:
[82-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
--
W
A
A
A
K
-
E
---
F
Y
---
Q
K
Y
D
P
-
K
D
-
V
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
--------
E
V
T
-
A
---------------
S
--
P
-----
E
----
Q
-----
L
E
E
VREATRR
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
-------
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
L
T
--
E
--
K
-
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
--
C
------
H
-----
L
---
E
PG
E
---
K
---
L
R
-
E
-
L
C
G
T
P
G
Y
L
A
P
E
I
---
L
KCSMDE
T
------
H
P
G
-----
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
-
R
----
R
-------
Q
-
I
L
-----
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
----
T
A
E
Q
-----
A
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------
260
Blastp_CBE
62.11
36%
-12
- C1 -
-
3MFS
1
CSKP_HUMAN
A:
[26-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
C
E
-
V
I
-
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--------
D
V
A
-
K
F
----
T
-------
S
-
S
--
P
-----
G
----
L
STED-
L
K
R
-------
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
--
A
-
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
-
A
S
K
E
N
S
A
P
V
K
L
G
D
F
G
V
A
--
I
QLGESG
L
-----
V
---
A
--
G
----------
G
-
R
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
------
R
E
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
------------
K
-
E
R
-----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
-----
A
L
N
H
P
W
-
L
-
K
E
R
D
RYAYKIH
L
P
E
T
V
E
Q
L
---------------------------------------------------------------------------------
292
Blastp_CBE
61.95
35%
-17
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[26-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
C
E
-
V
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--------
D
V
A
-
K
F
----
T
-------
S
-
S
--
P
-----
G
----
L
STED-
L
K
R
-------
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
--
A
-
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
-
A
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
QLGESG
L
-----
V
---
A
--
G
----------
G
-
R
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
------
R
E
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
------------
K
-
E
R
-----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
-----
A
L
N
H
P
W
-
L
-
K
E
R
D
RYAYKIH
L
P
E
T
V
E
Q
L
---------------------------------------------------------------------------------
135
Blastp_CBE
61.90
40%
-37
- C1 -
-
3LIJ
1
?
A:
[35-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
---
E
M
Y
Q
R
-
V
K
-
K
L
-
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
--------
R
K
------------------
S
--
S
-----
N
S---
K
-----
L
L
E
-------
E
V
A
V
L
K
L
L
-
D
-
H
-
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
----
Y
Y
-------
L
V
M
E
C
Y
K
G
G
E
L
-
F
D
E
I
I
--
H
--
R
-
M
----
K
---
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
E
K
D
A
L
I
K
I
V
D
F
G
L
S
--
A
------
V
-----
F
---
E
--
N
QK-
K
---
M
K
-
E
-
R
L
G
T
A
Y
Y
I
A
P
E
V
---
L
------
R
------
K
K
------
Y
-
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
-
G
-
G
Q
T
--
D
-------
Q
-
E
I
-----
L
-
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
-
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
----
S
A
Q
Q
-----
A
L
E
H
P
W
-
I
-
K
E
--------------------------------------------------------------------------------------------------
600
HHSearch
61.85
35%
-45
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[21-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
F
E
---
D
V
Y
E
L
-
C
E
-
V
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--------
D
V
A
-
K
F
----
T
SSPG---
L
-
S
--
T
-----
E
----
D
-----
L
K
R
-------
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
-
C
F
E
I
V
--
K
--
R
-
A
DAGF
V
---
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
------
Q
-----
L
---
G
--
E
---
S
GLV
A
G
-
G
-
R
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
------
R
E
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
K
E
-------------
R
-----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
-----
A
L
N
H
P
W
-
L
-
K
E
R
D
-------
R
----------------------------------------------------------------------------------------
289
Blastp_CBE
61.67
35%
-15
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[26-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
-
C
E
-
V
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--------
D
V
A
-
K
F
----
T
-------
S
-
S
--
P
-----
G
----
L
STED-
L
K
R
-------
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
--
R
--
A
-
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
-
A
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
QLGESG
L
-----
V
---
A
--
G
----------
G
-
R
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
------
R
E
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
------------
K
-
E
R
-----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
-----
A
L
N
H
P
W
-
L
-
K
E
R
D
RYAYKIH
L
P
E
T
V
E
Q
L
---------------------------------------------------------------------------------
73
Blastp_CBE
61.58
38%
-17
- C1 -
-
5VJA
2
DAPK3_HUMAN
A:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
M
---
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
R
---R---
R
-------
G
V
S
--
R
-----
E
----
E
-----
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
--
A
GN-
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
601
HHSearch
61.42
35%
-42
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[21-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
F
E
---
D
V
Y
E
L
-
C
E
-
V
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
--------
D
V
A
-
K
F
----
T
SSPG---
L
-
S
--
T
-----
E
----
D
-----
L
K
R
-------
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
-------
M
V
F
E
F
M
D
G
A
D
L
-
C
F
E
I
V
--
K
--
R
-
A
DAGF
V
---
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
------
Q
-----
L
---
G
--
E
---
S
GLV
A
G
-
G
-
R
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
------
R
E
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
-
T
K
E
-------------
R
-----
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
-----
A
L
N
H
P
W
-
L
-
K
E
R
D
-------
R
----------------------------------------------------------------------------------------
127
Blastp_CBE
61.33
38%
-5
- C1 -
-
2Y0A
1
DAPK1_HUMAN
A:
[8-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
195
Blastp_CBE
61.24
35%
-89
- C1 -
-
4BDG
2
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
--------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
192
Blastp_CBE
61.23
35%
-100
- C1 -
-
4BDJ
1
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
------
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
--------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
E--
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
105
Blastp_CBE
61.20
38%
-1
- C1 -
-
6FHB
2
DAPK1_HUMAN
A:
[12-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
101
Blastp_CBE
61.17
38%
3
- C1 -
-
1WVY
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
360
Blastp_CBE
61.08
36%
-120
- C1 -
-
5XZV
1
RAD53_YEAST
A:
[200-465]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
E
-
V
V
-
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
--------
S
K
R
-
K
V
----
I
-------
G
-
N
--
M
-----
D
----
G
-----
V
T
R
-------
E
L
E
V
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
----
Y
Y
-------
M
V
M
E
F
V
S
G
G
D
L
-
M
D
F
V
A
--
A
--
H
-
G
----
A
---
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
--
E
Q
D
D
P
V
L
V
K
I
T
D
F
G
L
A
--
K
------------------------------------
L
A
Y
V
A
P
E
V
---
I
--------------
N
E
-----
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
---
S
T
Q
--
D
-------
Q
--------
L
Y
K
Q
I
G
R
G
S
------
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
---
D
P
N
N
------
T
A
A
K
-----
A
L
N
H
P
W
-------------------------------------------------------------------------------------------------------
126
Blastp_CBE
61.07
38%
-2
- C1 -
-
4TXC
7
DAPK1_HUMAN
A:
[28-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
282
Blastp_CBE
61.01
39%
-23
- C1 -
-
4YZB
1
?
A:
[26-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
A
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
--------
S
K
R
---------------
Q
-
K
TD
K
-----
E
----
L
-----
L
L
K
-------
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
T
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
N
K
R
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
S
TK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
E
--
F
-------
D
--------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
----
S
A
R
D
-----
A
L
E
H
E
W
-
L
-----------------------------------------------------------------------------------------------------
55
Blastp_CBE
60.90
40%
-47
- C1 -
-
4JG7
1
A:
[33-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
G
Y
E
V
-
K
E
-
D
I
-
G
V
--
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
--------
D
K
S
-
K
R
----
D
-------
P
-
T
--
E
--------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
-------
V
V
T
E
L
M
K
G
G
E
L
-
L
D
K
I
L
--
R
--
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
------
Q
-----
L
RAE
N
--
G
---
L
---
L
M
-
T
-
P
C
Y
T
A
N
F
V
A
P
E
V
---
L
------
E
------
R
Q
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
-
G
P
D
--
D
-------
T
P
E
E
-----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
----
T
A
A
L
-----
V
L
R
H
P
W
I
V
-
H
W
D
Q
-------
L
P
Q
Y
Q
------------------------------------------------------------------------------------
196
Blastp_CBE
60.87
35%
-90
- C1 -
-
4BDF
3
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
--------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
80
Blastp_CBE
60.75
38%
0
- C1 -
-
2W4K
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
49
Blastp_CBE
60.74
40%
-46
- C1 -
-
4MAO
1
A:
[33-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
G
Y
E
V
-
K
E
-
D
I
-
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
--------
D
K
S
-
K
R
----
D
-------
P
-
T
--
E
--------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
-------
V
V
M
E
L
M
K
G
G
E
L
-
L
D
K
I
L
--
R
--
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
------
Q
-----
L
RAE
N
--
G
---
L
---
L
M
-
T
-
P
C
Y
T
A
N
F
V
A
P
E
V
---
L
------
E
------
R
Q
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
-
G
P
D
--
D
-------
T
P
E
E
-----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
----
T
A
A
L
-----
V
L
R
H
P
W
I
V
-
H
W
D
Q
-------
L
P
Q
Y
Q
------------------------------------------------------------------------------------
245
Blastp_CBE
60.70
38%
-23
- C1 -
-
3UPX
1
?
A:
[22-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
187
Blastp_CBE
60.68
35%
-95
- C1 -
-
2YCS
1
CHK2_HUMAN
A:
[5-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
--------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
---
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
238
Blastp_CBE
60.64
38%
-22
- C1 -
-
4ONA
1
?
A:
[22-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
198
Blastp_CBE
60.61
35%
-102
- C1 -
-
4BDD
3
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
--------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
---
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
242
Blastp_CBE
60.53
38%
-22
- C1 -
-
3V5P
1
?
A:
[22-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
50
Blastp_CBE
60.51
40%
-47
- C1 -
-
4M8T
1
A:
[33-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
G
Y
E
V
-
K
E
-
D
I
-
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
--------
D
K
S
-
K
R
----
D
-------
P
-
T
--
E
--------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
-------
V
V
M
E
L
M
K
G
G
E
L
-
L
D
K
I
L
--
R
--
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
------
Q
-----
L
RAE
N
--
G
---
L
---
L
M
-
T
-
P
C
Y
T
A
N
F
V
A
P
E
V
---
L
------
E
------
R
Q
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
-
G
P
D
--
D
-------
T
P
E
E
-----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
----
T
A
A
L
-----
V
L
R
H
P
W
I
V
-
H
W
D
Q
-------
L
P
Q
Y
Q
------------------------------------------------------------------------------------
104
Blastp_CBE
60.42
38%
-1
- C1 -
-
6QMO
7
DAPK1_HUMAN
A:
[12-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
156
Blastp_CBE
60.41
38%
-8
- C1 -
-
2CKE
1
DAPK2_HUMAN
B:
[14-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
-
Q
S
----
R
-------
A
-
S
--
R
RGVSR
E
----
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
Q
--
K
-
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H-
E
------
I
-----
E
---
D
--
G
---
V
---
E
F
K
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
----
T
I
Q
E
-----
A
L
R
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
250
Blastp_CBE
60.39
38%
-17
- C1 -
-
3N51
3
?
A:
[22-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
68
Blastp_CBE
60.37
40%
-51
- C1 -
-
3IGO
8
?
A:
[17-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
-
T
---
F
A
---
E
R
Y
N
I
-
V
C
-
M
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
--------
N
K
A
-
S
A
----
K
-------
N
-
K
---T----
S
----
T
-----
I
L
R
-------
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
-------
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
--
K
--
R
-
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
------
C
-----
F
QQ-
N
--
T
---------------
T
A
Y
Y
I
A
P
E
V
---
L
------
R
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
--
Y
-------
D
--------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
----
T
A
T
Q
-----
C
L
E
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
277
Blastp_CBE
60.32
37%
-58
- C1 -
-
6CJ5
1
MKNK2_HUMAN
A:
[20-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
--------
E
K
Q
-
P
G
----
H
-------
I
-
R
--
S
-----
R
----
V
-----
F
R
--------
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
-------
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
--
K
--
R
-
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
-
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
---------------------------------------
G
S
A
E
Y
M
A
P
E
V
---
V
------
E
------
A
F
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
-----CGACPAC
Q
-
N
M
-----
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
----
S
A
A
Q
-----
V
L
Q
H
P
W
-
V
-
Q
G
C
-------------------------------------------------------------------------------------------------
179
Blastp_CBE
60.33
39%
-25
- C1 -
-
4IEB
1
?
A:
[45-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
---------------TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
M
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
-
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
258
Blastp_CBE
60.32
38%
-20
- C1 -
-
4MX9
1
?
A:
[23-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
Y
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
96
Blastp_CBE
60.32
38%
1
- C1 -
-
2YAK
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
128
Blastp_CBE
60.31
38%
-2
- C1 -
-
4UV0
1
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
103
Blastp_CBE
60.21
38%
-2
- C1 -
-
4PF4
6
DAPK1_HUMAN
A:
[10-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
225
Blastp_CBE
60.20
38%
-18
- C1 -
-
5JMS
2
?
A:
[63-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
181
Blastp_CBE
60.19
35%
-88
- C1 -
-
2YCR
1
CHK2_HUMAN
A:
[5-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
--------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
155
Blastp_CBE
60.17
38%
-2
- C1 -
-
2CKE
1
DAPK2_HUMAN
C:
[14-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
-
Q
S
----
R
-------
A
-
S
--
R
RGVSR
E
----
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
Q
--
K
-
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H-
E
------
I
-----
E
---
D
--
G
---
V
---
E
F
K
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
----
T
I
Q
E
-----
A
L
R
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
194
Blastp_CBE
60.14
35%
-95
- C1 -
-
4BDH
4
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
--------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
229
Blastp_CBE
60.11
38%
-19
- C1 -
-
5W9E
1
?
A:
[22-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
214
Blastp_CBE
60.10
35%
-88
- C1 -
-
2CN5
1
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
R
-------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
78
Blastp_CBE
60.10
38%
0
- C1 -
-
3BQR
4
DAPK3_HUMAN
A:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
M
---
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
R
-
R
L
SSSR
R
-------
G
V
S
--
R
-----
E
----
E
-----
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
--
A
GN--------
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
235
Blastp_CBE
60.08
38%
-22
- C1 -
-
4WG4
1
?
A:
[22-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
72
Blastp_CBE
60.05
38%
-19
- C1 -
-
5VJA
2
DAPK3_HUMAN
B:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
M
---
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
----R---
R
-------
G
V
S
--
R
-----
E
----
E
-----
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
--
A
GN-
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
270
Blastp_CBE
60.03
37%
-52
- C1 -
-
6CKI
1
MKNK2_HUMAN
A:
[20-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
--------
E
K
Q
-
P
G
----
H
-------
I
-
R
--
S
-----
R
----
V
-----
F
R
--------
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
-------
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
--
K
--
R
-
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
-
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
---------------------------------------
G
S
A
E
Y
M
A
P
E
V
---
V
------
E
------
A
F
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
-----CGACPAC
Q
-
N
M
-----
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
----
S
A
A
Q
-----
V
L
Q
H
P
W
-
V
-
Q
G
C
-------------------------------------------------------------------------------------------------
234
Blastp_CBE
60.00
38%
-21
- C1 -
-
4WG5
1
?
A:
[22-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
257
Blastp_CBE
59.99
38%
-18
- C1 -
-
4MXA
1
?
A:
[23-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
Y
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
115
Blastp_CBE
59.98
38%
-4
- C1 -
-
5AV3
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
218
Blastp_CBE
59.95
38%
-13
- C1 -
-
4IFG
1
?
A:
[45-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
56
Blastp_CBE
59.91
40%
-49
- C1 -
-
4JG6
1
A:
[33-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
G
Y
E
V
-
K
E
-
D
I
------
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
--------
D
K
S
-
K
R
----
D
-------
P
-
T
--
E
--------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
-------
V
V
T
E
L
M
K
G
G
E
L
-
L
D
K
I
L
--
R
--
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
------
Q
-----
L
RAE
N
--
G
---
L
---
L
M
-
T
-
P
C
Y
T
A
N
F
V
A
P
E
V
---
L
------
E
------
R
Q
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
-
G
P
D
--
D
-------
T
P
E
E
-----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
----
T
A
A
L
-----
V
L
R
H
P
W
I
V
-
H
W
D
Q
-------
L
P
Q
Y
Q
------------------------------------------------------------------------------------
70
Blastp_CBE
59.88
38%
-14
- C1 -
-
5VJA
3
DAPK3_HUMAN
D:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
M
---
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
R
-
R
L
S------------V
S
--
R
-----
E
----
E
-----
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
-----
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
--
A
GN-
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
91
Blastp_CBE
59.85
38%
-3
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
201
Blastp_CBE
59.75
35%
-97
- C1 -
-
4BDA
8
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
--------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
E--
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
107
Blastp_CBE
59.75
38%
-1
- C1 -
-
2W4J
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
57
Blastp_CBE
59.73
40%
-48
- C1 -
-
5O1S
2
A:
[42-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
G
Y
E
V
-
K
E
-
D
I
------
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
--------
D
K
S
-
K
R
----
D
-------
P
-
T
--
E
--------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
-------
V
V
T
E
L
M
K
G
G
E
L
-
L
D
K
I
L
--
R
--
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
------
Q
-----
L
RAE
N
--
G
---
L
---
L
M
-
T
-
P
C
---
N
F
V
A
P
E
V
---
L
------
E
------
R
Q
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
-
G
P
D
--
D
-------
T
P
E
E
-----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
----
T
A
A
L
-----
V
L
R
H
P
W
I
V
-
H
W
D
Q
-------
L
P
Q
Y
Q
------------------------------------------------------------------------------------
122
Blastp_CBE
59.71
38%
-7
- C1 -
-
5AUW
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
----------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
154
Blastp_CBE
59.68
38%
-7
- C1 -
-
2CKE
1
DAPK2_HUMAN
D:
[14-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
-
Q
S
----
R
-------
A
-
S
--
R
RGVSR
E
----
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
Q
--
K
-
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H-
E
------
I
-----
E
---
D
--
G
---
V
---
E
F
K
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
----
T
I
Q
E
-----
A
L
R
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
224
Blastp_CBE
59.65
38%
-19
- C1 -
-
5JN2
1
?
A:
[63-342]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
230
Blastp_CBE
59.64
38%
-19
- C1 -
-
5W91
1
?
A:
[22-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
106
Blastp_CBE
59.64
38%
2
- C1 -
-
6QN4
4
DAPK1_HUMAN
A:
[12-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
121
Blastp_CBE
59.62
38%
-0
- C1 -
-
5AUX
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
271
Blastp_CBE
59.60
37%
-52
- C1 -
-
6CK6
1
MKNK2_HUMAN
A:
[20-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
--------
E
K
Q
-
P
G
----
H
-------
I
-
R
--
S
-----
R
----
V
-----
F
R
--------
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
-------
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
--
K
--
R
-
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
-
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
---------------------------------------
G
S
A
E
Y
M
A
P
E
V
---
V
------
E
------
A
F
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
-----CGACPAC
Q
-
N
M
-----
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
----
S
A
A
Q
-----
V
L
Q
H
P
W
-
V
-
Q
G
C
-------------------------------------------------------------------------------------------------
247
Blastp_CBE
59.53
38%
-16
- C1 -
-
3T3U
5
?
A:
[22-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
227
Blastp_CBE
59.53
38%
-18
- C1 -
-
6BFA
1
?
A:
[22-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
138
Blastp_CBE
59.52
39%
-8
- C1 -
-
2YAA
1
DAPK2_MOUSE
B:
[14-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
-
Q
S
----
R
-------
A
-
S
--
R
RGVCR
E
----
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
Q
--
K
-
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H-
E
------
I
-----
E
---
D
--
G
---
V
---
E
F
K
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
-
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
----
T
I
Q
E
-----
A
L
R
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
239
Blastp_CBE
59.51
38%
-18
- C1 -
-
4M84
1
?
A:
[22-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
71
Blastp_CBE
59.48
38%
-4
- C1 -
-
5VJA
2
DAPK3_HUMAN
C:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
M
---
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
R
-
R
L
SS----------
G
V
S
--
R
-----
E
----
E
-----
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
----
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
--
A
GN-
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
157
Blastp_CBE
59.46
38%
-4
- C1 -
-
2CKE
1
DAPK2_HUMAN
A:
[14-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
-
Q
S
----
R
-------
A
-
S
--
R
RGVSR
E
----
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
Q
--
K
-
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H-
E
------
I
-----
E
---
D
--
G
---
V
---
E
F
K
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
----
T
I
Q
E
-----
A
L
R
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
278
Blastp_CBE
59.41
37%
-48
- C1 -
-
2HW7
1
MKNK2_HUMAN
A:
[20-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
--------
E
K
Q
-
P
G
----
H
-------
I
-
R
--
S
-----
R
----
V
-----
F
R
--------
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
-------
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
--
K
--
R
-
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
-
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
---------------------------------------
G
S
A
E
Y
M
A
P
E
V
---
V
------
E
------
A
F
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
-----CGACPAC
Q
-
N
M
-----
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
----
S
A
A
Q
-----
V
L
Q
H
P
W
-
V
-
Q
G
C
-------------------------------------------------------------------------------------------------
178
Blastp_CBE
59.41
38%
-24
- C1 -
-
4CZU
3
CIPKN_ARATH
A:
[12-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
-
G
R
-
T
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
--------
D
K
E
-
K
V
----
L
-------
K
-
N
--
K
-----
M
----
I
AQ---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
-------
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
--
S
--
N
-
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
------
L
PQQVR
E
---
D
--
G
---
L
---
L
H
-
D
-
T
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
------
N
K
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
----
N
-------
L
-
T
S
-----
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
----
T
F
A
E
-----
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------
221
Blastp_CBE
59.34
38%
-11
- C1 -
-
5T6K
1
?
A:
[63-358]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
K--
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
116
Blastp_CBE
59.33
38%
-1
- C1 -
-
5AV2
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
75
Blastp_CBE
59.32
38%
4
- C1 -
-
5A6O
3
DAPK3_HUMAN
A:
[3-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
R
-
R
L
SSSR
R
-------
G
V
S
--
R
-----
E
----
E
-----
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
-----------
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
276
Blastp_CBE
59.31
37%
-56
- C1 -
-
6CJE
1
MKNK2_HUMAN
A:
[20-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
--------
E
K
Q
-
P
G
----
H
-------
I
-
R
--
S
-----
R
----
V
-----
F
R
--------
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
-------
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
--
K
--
R
-
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
-
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-------------------------------------
P
C
G
S
A
E
Y
M
A
P
E
V
---
V
------
E
------
A
F
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
-----CGACPAC
Q
-
N
M
-----
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
----
S
A
A
Q
-----
V
L
Q
H
P
W
-
V
-
Q
G
C
-------------------------------------------------------------------------------------------------
404
Blastp_CBE
59.30
36%
-40
- C1 -
-
2OH0
1
KAPCA_BOVIN
E:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
273
Blastp_CBE
59.28
37%
-47
- C1 -
-
6CJY
1
MKNK2_HUMAN
A:
[20-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
--------
E
K
Q
-
P
G
----
H
-------
I
-
R
--
S
-----
R
----
V
-----
F
R
--------
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
-------
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
--
K
--
R
-
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
-
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
---------------------------------------
G
S
A
E
Y
M
A
P
E
V
---
V
------
E
------
A
F
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
-----CGACPAC
Q
-
N
M
-----
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
----
S
A
A
Q
-----
V
L
Q
H
P
W
-
V
-
Q
G
C
-------------------------------------------------------------------------------------------------
246
Blastp_CBE
59.28
38%
-20
- C1 -
-
3T3V
2
?
A:
[22-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
74
Blastp_CBE
59.28
38%
8
- C1 -
-
5A6O
2
DAPK3_HUMAN
B:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
M
---
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
R
-
R
L
SSSR
R
-------
G
V
S
--
R
-----
E
----
E
-----
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
-----------
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
118
Blastp_CBE
59.26
38%
-2
- C1 -
-
5AV0
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
124
Blastp_CBE
59.22
38%
-4
- C1 -
-
5AUU
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
-------
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
125
Blastp_CBE
59.21
38%
-4
- C1 -
-
5AUT
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
-------
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
207
Blastp_CBE
59.20
35%
-100
- C1 -
-
2XM8
1
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
------
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------------------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
---
T
--
S
---
L
---
M
R
-
T
-
L
C
G
---
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
213
Blastp_CBE
59.18
35%
-96
- C1 -
-
2CN8
1
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
--------------------------------
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
---
T
--
S
---
L
---
M
R
-
T
-
L
C
--
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
-------------
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
503
Blastp_CBE
59.15
33%
-9
- C1 -
-
3MVJ
1
KAPCA_HUMAN
A:
[36-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
-
Q
---
N
T
AHL
D
Q
F
E
R
-
I
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
123
Blastp_CBE
59.14
38%
0
- C1 -
-
5AUV
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
228
Blastp_CBE
59.12
38%
-18
- C1 -
-
5W9R
1
?
A:
[22-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
223
Blastp_CBE
59.10
38%
-15
- C1 -
-
5T6A
1
?
A:
[63-358]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
K--
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
114
Blastp_CBE
59.10
38%
-6
- C1 -
-
5AV4
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
-------
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
119
Blastp_CBE
59.07
38%
-4
- C1 -
-
5AUZ
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
-------
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
232
Blastp_CBE
59.04
38%
-18
- C1 -
-
5W80
1
?
A:
[22-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
432
Blastp_CBE
58.97
37%
-41
- C1 -
-
2GNH
2
KAPCA_BOVIN
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
I
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
M
P
G
G
D
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
175
Blastp_CBE
58.95
38%
-15
- C1 -
-
4CZU
3
CIPKN_ARATH
D:
[12-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
-
G
R
-
T
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
--------
D
K
E
-
K
V
----
L
-------
K
-
N
--
K
-----
M
----
I
AQ---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
-------
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
--
S
--
N
-
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
------
L
PQQVR
E
---
D
--
G
---
L
---
L
H
-
D
-
T
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
------
N
K
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
----
N
-------
L
-
T
S
-----
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
----
T
F
A
E
-----
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------
272
Blastp_CBE
58.94
37%
-45
- C1 -
-
6CK3
1
MKNK2_HUMAN
A:
[20-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
--------
E
K
Q
-
P
G
----
H
-------
I
-
R
--
S
-----
R
----
V
-----
F
R
--------
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
-------
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
--
K
--
R
-
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
-
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
---------------------------------------
G
S
A
E
Y
M
A
P
E
V
---
V
------
E
------
A
F
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
-----CGACPAC
Q
-
N
M
-----
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
----
S
A
A
Q
-----
V
L
Q
H
P
W
-
V
-
Q
G
C
-------------------------------------------------------------------------------------------------
169
Blastp_CBE
58.94
39%
-26
- C1 -
-
4CZT
3
CIPKN_ARATH
C:
[12-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
-
G
R
-
T
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
--------
D
K
E
-
K
V
----
L
-------
K
-
N
--
K
-----
M
----
I
AQ---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
-------
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
--
S
--
N
-
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
------
L
PQQVR
E
---
D
--
G
---
L
---
L
H
-
T
-
T
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
------
N
K
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
----
N
-------
L
-
T
S
-----
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
----
T
F
A
E
-----
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------
32
Blastp_CBE
58.90
42%
-2
- C1 -
-
5HU3
1
KCC2A_DROME
A:
[9-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
T
RFS
D
N
Y
D
I
-
K
E
-
E
L
-
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
--------
N
T
K
-
K
L
----
T
-------
A
-
R
--
D
-----
F
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
F
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DHQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
K
------
K
E
P
-----
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
--
D
-------
Q
-
H
R
-----
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
----
T
A
A
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
522
Blastp_CBE
58.85
36%
-36
- C1 -
-
5LCR
5
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
217
Blastp_CBE
58.85
38%
-13
- C1 -
-
4IH8
1
?
A:
[45-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
--
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
79
Blastp_CBE
58.84
38%
4
- C1 -
-
3BHY
1
DAPK3_HUMAN
A:
[2-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
R
-
R
L
SSSR
R
-------
G
V
S
--
R
-----
E
----
E
-----
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
----------------
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
512
Blastp_CBE
58.82
36%
-37
- C1 -
-
5M75
2
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
431
Blastp_CBE
58.80
37%
-40
- C1 -
-
2GNI
1
KAPCA_BOVIN
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
I
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
M
P
G
G
D
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
89
Blastp_CBE
58.80
38%
-5
- C1 -
-
2XUU
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
A
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
120
Blastp_CBE
58.79
38%
3
- C1 -
-
5AUY
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
468
Blastp_CBE
58.78
33%
1
- C1 -
-
6C0U
4
KAPCA_HUMAN
A:
[15-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
-
Q
---
N
T
AHL
D
Q
F
E
R
-
I
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
551
Blastp_CBE
58.77
35%
-33
- C1 -
-
1CDK
2
KAPCA_PIG
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
DGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
251
Blastp_CBE
58.76
38%
-19
- C1 -
-
3I7B
4
?
A:
[23-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
77
Blastp_CBE
58.67
38%
-0
- C1 -
-
5A6N
4
DAPK3_HUMAN
A:
[2-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
R
-
R
L
SSSR
R
-------
G
V
S
--
R
-----
E
----
E
-----
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
--
A
GN-
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
498
Blastp_CBE
58.63
36%
-44
- C1 -
-
3L9L
1
KAPCA_HUMAN
B:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
520
Blastp_CBE
58.60
36%
-39
- C1 -
-
5LCU
5
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
500
Blastp_CBE
58.62
36%
-38
- C1 -
-
3AGM
1
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
58.61
41%
-1
- C1 -
-
5FG8
3
KCC2A_DROME
A:
[9-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
T
RFS
D
N
Y
D
I
-
K
E
-
E
L
-
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
--------
N
T
K
-
K
L
----
T
-------
A
-
R
--
D
F----
Q
----
K
-----
L
E
R
-------
E
A
R
I
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
F
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
A
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DHQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
K
------
K
E
P
-----
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
--
D
-------
Q
-
H
R
-----
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
----
T
A
A
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
429
Blastp_CBE
58.60
37%
-38
- C1 -
-
2GNF
1
KAPCA_BOVIN
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
I
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
M
P
G
G
D
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
495
Blastp_CBE
58.56
36%
-34
- C1 -
-
3OWP
1
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
521
Blastp_CBE
58.51
36%
-37
- C1 -
-
5LCT
3
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
554
Blastp_CBE
58.49
36%
-42
- C1 -
-
1YDS
1
KAPCA_BOVIN
E:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
DGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
166
Blastp_CBE
58.46
38%
5
- C1 -
-
1QL6
1
PHKG1_RABIT
A:
[17-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
-
K
E
-
I
L
-
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
DVTGGGSF
S
A
E
-
E
V
----
Q
-------
E
-
L
--
R
-----
E
----
A
-----
T
L
K
-------
E
V
D
I
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
-------
L
V
F
D
L
M
K
K
G
E
L
-
F
D
Y
L
T
--
E
--
K
-
V
----
T
---
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
--
C
------
Q
-----
L
---
D
PG
E
---
K
---
L
R
-
S
-
V
C
G
T
P
S
Y
L
A
P
E
I
---
I
------
E
CSMNDN
H
P
G
-----
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
-
R
----
K
-------
Q
-
M
L
-----
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
-
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
----
T
A
E
E
-----
A
L
A
H
P
F
-
F
-
Q
Q
Y
V
------------------------------------------------------------------------------------------------
513
Blastp_CBE
58.43
36%
-40
- C1 -
-
5M71
2
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
524
Blastp_CBE
58.44
36%
-39
- C1 -
-
5LCP
3
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
168
Blastp_CBE
58.43
39%
-22
- C1 -
-
4CZT
4
CIPKN_ARATH
D:
[12-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
-
G
R
-
T
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
--------
D
K
E
-
K
V
----
L
-------
K
-
N
--
K
-----
M
----
I
AQ---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
-------
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
--
S
--
N
-
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
------
L
PQQVR
E
---
D
--
G
---
L
---
L
H
-
T
-
T
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
------
N
K
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
----
N
-------
L
-
T
S
-----
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
----
T
F
A
E
-----
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------
171
Blastp_CBE
58.42
39%
-21
- C1 -
-
4CZT
3
CIPKN_ARATH
A:
[12-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
-
G
R
-
T
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
--------
D
K
E
-
K
V
----
L
-------
K
-
N
--
K
-----
M
----
I
AQ---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
-------
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
--
S
--
N
-
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
------
L
PQQVR
E
---
D
--
G
---
L
---
L
H
-
T
-
T
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
------
N
K
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
----
N
-------
L
-
T
S
-----
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
----
T
F
A
E
-----
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------
170
Blastp_CBE
58.41
39%
-18
- C1 -
-
4CZT
2
CIPKN_ARATH
B:
[12-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
-
G
R
-
T
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
--------
D
K
E
-
K
V
----
L
-------
K
-
N
--
K
-----
M
----
I
AQ---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
-------
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
--
S
--
N
-
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
------
L
PQQVR
E
---
D
--
G
---
L
---
L
H
-
T
-
T
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
------
N
K
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
----
N
-------
L
-
T
S
-----
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
----
T
F
A
E
-----
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------
527
Blastp_CBE
58.38
36%
-35
- C1 -
-
5BX6
4
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
176
Blastp_CBE
58.37
38%
-23
- C1 -
-
4CZU
3
CIPKN_ARATH
C:
[12-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
-
G
R
-
T
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
--------
D
K
E
-
K
V
----
L
-------
K
-
N
--
K
-----
M
----
I
AQ---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
-------
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
--
S
--
N
-
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
------
L
PQQVR
E
---
D
--
G
---
L
---
L
H
-
D
-
T
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
------
N
K
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
----
N
-------
L
-
T
S
-----
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
----
T
F
A
E
-----
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------
186
Blastp_CBE
58.35
35%
-86
- C1 -
-
2YIQ
1
CHK2_HUMAN
A:
[5-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
--------------------------------------
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
510
Blastp_CBE
58.33
36%
-33
- C1 -
-
5N1D
3
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
139
Blastp_CBE
58.31
39%
-6
- C1 -
-
2YAA
1
DAPK2_MOUSE
A:
[14-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
-
Q
S
----
R
-------
A
-
S
--
R
RGVCR
E
----
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
Q
--
K
-
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H-
E
------
I
-----
E
---
D
--
G
---
V
---
E
F
K
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
---
L
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
-
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
----
T
I
Q
E
-----
A
L
R
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
65
Blastp_CBE
58.28
40%
-49
- C1 -
-
4Y5Q
1
?
A:
[14-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
G
-
T
---
F
A
---
E
R
Y
N
I
-
V
C
-
M
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
--------
N
K
A
-
S
A
----
K
-------
N
-
K
--
D
T----
S
----
T
-----
I
L
R
-------
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
-------
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
--
K
--
R
-
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
------
C
-----
F
QQ-
N
--
T
----------
D
-
R
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
R
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
--
Y
-------
D
--------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
----
T
A
T
Q
-----
C
L
E
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
534
Blastp_CBE
58.27
35%
-40
- C1 -
-
4HPT
1
KAPCA_MOUSE
E:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
497
Blastp_CBE
58.25
36%
-36
- C1 -
-
3OOG
1
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
501
Blastp_CBE
58.23
33%
-7
- C1 -
-
3MVJ
1
KAPCA_HUMAN
E:
[36-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
-
Q
---
N
T
AHL
D
Q
F
E
R
-
I
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
491
Blastp_CBE
58.22
36%
-32
- C1 -
-
4UJ1
2
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
562
Blastp_CBE
58.21
35%
-41
- C1 -
-
3L9N
1
KAPCA_HUMAN
A:
[48-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
----
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
566
Blastp_CBE
58.15
35%
-40
- C1 -
-
6MM8
4
KAPCA_MOUSE
C:
[36-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
58.18
41%
1
- C1 -
-
5H9B
2
KCC2A_DROME
A:
[9-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
T
RFS
D
N
Y
D
I
-
K
E
-
E
L
-
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
--------
N
T
K
-
K
L
----
T
-------
A
-
R
--
D
F----
Q
----
K
-----
L
E
R
-------
E
A
R
I
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
F
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
A
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DHQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
K
------
K
E
P
-----
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
E
--
D
-------
Q
-
H
R
-----
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
----
T
A
A
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
515
Blastp_CBE
58.16
36%
-34
- C1 -
-
5M6V
1
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
553
Blastp_CBE
58.15
36%
-39
- C1 -
-
1YDT
1
KAPCA_BOVIN
E:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
DGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
490
Blastp_CBE
58.14
36%
-32
- C1 -
-
4UJ2
2
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
488
Blastp_CBE
58.12
36%
-33
- C1 -
-
4UJA
2
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
415
Blastp_CBE
58.11
36%
-38
- C1 -
-
2UZW
1
KAPCA_BOVIN
E:
[33-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
DGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
76
Blastp_CBE
58.10
38%
9
- C1 -
-
5A6N
1
DAPK3_HUMAN
B:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
M
---
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
R
-
R
L
SSSR
R
-------
G
V
S
--
R
-----
E
----
E
-----
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
-----------
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
599
HHSearch
58.06
33%
-49
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
S
K
-
T
E
-
I
L
------
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
--------
K
T
R
-
G
M
----
K
---------
D
--
K
-----
E
----
E
-----
V
K
N
-------
E
I
S
V
M
N
Q
L
-
D
-
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
----
I
V
-------
L
V
M
E
Y
V
D
G
G
E
L
-
F
D
R
I
I
--
D
--
E
S
Y
----
N
---
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
--
R
D
A
K
Q
I
K
I
I
D
F
G
L
A
--
R
------
R
-----
Y
---
K
--
P
---
R
EK-
L
K
-
V
-
N
F
G
T
P
E
F
L
A
P
E
V
---
V
------
N
------
Y
D
F
-----
V
-
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
-
D
N
D
--
A
----------
E
-----
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
-
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
----
S
A
S
E
-----
A
L
K
H
P
W
-
L
-
S
D
H
K
------------------------------------------------------------------------------------------------
499
Blastp_CBE
58.04
36%
-43
- C1 -
-
3L9L
1
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
417
Blastp_CBE
58.03
36%
-37
- C1 -
-
2UZU
1
KAPCA_BOVIN
E:
[33-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
DGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
552
Blastp_CBE
58.01
35%
-41
- C1 -
-
2ERZ
1
KAPCA_MOUSE
E:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
555
Blastp_CBE
57.97
36%
-40
- C1 -
-
1YDR
1
KAPCA_BOVIN
E:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
DGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
67
Blastp_CBE
57.99
40%
-50
- C1 -
-
3MWU
1
?
A:
[14-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
G
-
T
---
F
A
---
E
R
Y
N
I
-
V
C
-
M
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
--------
N
K
A
-
S
A
----
K
-------
N
-
K
--
D
T----
S
----
T
-----
I
L
R
-------
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
-------
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
--
K
--
R
-
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
------
C
-----
F
QQ-
N
-------------
D
-
R
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
R
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
--
Y
-------
D
--------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
----
T
A
T
Q
-----
C
L
E
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
528
Blastp_CBE
57.97
36%
-31
- C1 -
-
4UJB
3
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
571
Blastp_CBE
57.93
35%
-34
- C1 -
-
6MM5
1
KAPCA_MOUSE
E:
[36-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
564
Blastp_CBE
57.95
35%
-39
- C1 -
-
3L9M
1
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
----
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
542
Blastp_CBE
57.93
35%
-42
- C1 -
-
1REJ
1
KAPCA_MOUSE
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
569
Blastp_CBE
57.88
35%
-40
- C1 -
-
6MM6
1
KAPCA_MOUSE
E:
[36-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
407
Blastp_CBE
57.88
36%
-39
- C1 -
-
2F7E
1
KAPCA_BOVIN
E:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
493
Blastp_CBE
57.86
36%
-35
- C1 -
-
3P0M
1
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
514
Blastp_CBE
57.85
36%
-34
- C1 -
-
5M6Y
2
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
526
Blastp_CBE
57.80
36%
-33
- C1 -
-
5BX7
4
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
492
Blastp_CBE
57.80
36%
-33
- C1 -
-
3POO
2
KAPCA_HUMAN
A:
[48-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
568
Blastp_CBE
57.81
35%
-42
- C1 -
-
6MM7
6
KAPCA_MOUSE
A:
[36-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
567
Blastp_CBE
57.77
35%
-39
- C1 -
-
6MM7
9
KAPCA_MOUSE
D:
[36-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
563
Blastp_CBE
57.77
35%
-43
- C1 -
-
3L9M
1
KAPCA_HUMAN
B:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
A
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
----
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
177
Blastp_CBE
57.80
38%
-18
- C1 -
-
4CZU
3
CIPKN_ARATH
B:
[12-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
E
L
-
G
R
-
T
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
--------
D
K
E
-
K
V
----
L
-------
K
-
N
--
K
-----
M
----
I
AQ---
I
K
R
-------
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
-------
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
--
S
--
N
-
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
------
L
PQQVR
E
---
D
--
G
---
L
---
L
H
-
D
-
T
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
------
N
K
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
-
S
----
N
-------
L
-
T
S
-----
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
----
T
F
A
E
-----
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------
443
Blastp_CBE
57.79
37%
-38
- C1 -
-
2GNL
1
KAPCA_BOVIN
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
I
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
546
Blastp_CBE
57.78
35%
-39
- C1 -
-
1ATP
1
KAPCA_MOUSE
E:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
496
Blastp_CBE
57.77
36%
-36
- C1 -
-
3OVV
2
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
529
Blastp_CBE
57.70
36%
-32
- C1 -
-
3VQH
2
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
66
Blastp_CBE
57.69
40%
-51
- C1 -
-
3NCG
1
?
A:
[14-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
G
-
T
---
F
A
---
E
R
Y
N
I
-
V
C
-
M
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
--------
N
K
A
-
S
A
----
K
-------
N
-
K
--
D
T----
S
----
T
-----
I
L
R
-------
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
-------
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
--
K
--
R
-
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
------
C
-----
F
QQ-
N
--
T
-------------
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
R
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
--
Y
-------
D
--------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
----
T
A
T
Q
-----
C
L
E
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
530
Blastp_CBE
57.65
36%
-35
- C1 -
-
3AGL
1
KAPCA_HUMAN
B:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
541
Blastp_CBE
57.64
35%
-35
- C1 -
-
1REK
2
KAPCA_MOUSE
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
523
Blastp_CBE
57.63
36%
-33
- C1 -
-
5LCQ
3
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
531
Blastp_CBE
57.60
36%
-33
- C1 -
-
3AGL
1
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
533
Blastp_CBE
57.55
37%
-23
- C1 -
-
6C9H
2
AAPK1_HUMAN
A:
[15-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
F--
L
R
-
T
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
506
Blastp_CBE
57.55
36%
-33
- C1 -
-
5N7P
2
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
418
Blastp_CBE
57.55
36%
-37
- C1 -
-
2UZT
1
KAPCA_BOVIN
A:
[33-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
DGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
550
Blastp_CBE
57.52
35%
-34
- C1 -
-
1CDK
2
KAPCA_PIG
B:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
DGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
444
Blastp_CBE
57.51
37%
-35
- C1 -
-
2GNJ
1
KAPCA_BOVIN
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
I
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
447
Blastp_CBE
57.46
36%
-36
- C1 -
-
3NX8
3
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLK
N
G
V
N
-----
D
I
N
H
K
W
-------------------------------------------------------------------------------------------------------
58
Blastp_CBE
57.44
39%
-39
- C1 -
-
2WEI
1
?
A:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
Y
F
Q
G
-
T
---
F
A
---
E
R
Y
N
I
-
V
C
-
M
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
--------
N
K
A
-
S
A
----
K
-------
N
-
K
--
D
T----
S
----
T
-----
I
L
R
-------
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
-------
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
--
K
--
R
-
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
------
C
-----
F
QQ-
N
--
T
---
K
---
M
K
-
D
-
R
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
R
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
-
K
N
E
--
Y
-------
D
--------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
----
T
A
T
Q
-----
C
L
E
H
P
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
172
Blastp_CBE
57.43
38%
-16
- C1 -
-
3MA6
1
?
B:
[29-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
--TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
SK-
K
---
M
K
-
D
-
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
N
E
--
Y
-------
D
--------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
545
Blastp_CBE
57.42
35%
-41
- C1 -
-
1FMO
1
KAPCA_MOUSE
E:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
403
Blastp_CBE
57.28
36%
-37
- C1 -
-
2OJF
1
KAPCA_BOVIN
E:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
548
Blastp_CBE
57.24
35%
-39
- C1 -
-
1BX6
1
KAPCA_MOUSE
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
547
Blastp_CBE
57.26
35%
-31
- C1 -
-
1JBP
2
KAPCA_MOUSE
E:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
--
E
-------
P
-
I
Q
-----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
519
Blastp_CBE
57.25
36%
-31
- C1 -
-
5M0B
3
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
494
Blastp_CBE
57.22
36%
-29
- C1 -
-
3OXT
1
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
482
Blastp_CBE
57.22
36%
-36
- C1 -
-
6F14
2
KAPCA_CRIGR
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
----
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
517
Blastp_CBE
57.24
36%
-32
- C1 -
-
5M0L
3
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
167
Blastp_CBE
57.22
38%
2
- C1 -
-
1PHK
1
PHKG1_RABIT
A:
[17-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
-
K
E
-
I
L
-
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
DVTGGGSF
S
A
E
-
E
V
----
Q
-------
E
-
L
--
R
-----
E
----
A
-----
T
L
K
-------
E
V
D
I
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
-------
L
V
F
D
L
M
K
K
G
E
L
-
F
D
Y
L
T
--
E
--
K
-
V
----
T
---
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
--
C
------
Q
-----
L
---
D
PG
E
---
K
---
L
R
-
E
-
V
C
G
T
P
S
Y
L
A
P
E
I
---
I
------
E
CSMNDN
H
P
G
-----
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
-
R
----
K
-------
Q
-
M
L
-----
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
-
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
----
T
A
E
E
-----
A
L
A
H
P
F
-
F
-
Q
Q
Y
V
------------------------------------------------------------------------------------------------
406
Blastp_CBE
57.20
36%
-35
- C1 -
-
2F7X
1
KAPCA_BOVIN
E:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
509
Blastp_CBE
57.18
36%
-31
- C1 -
-
5N1E
4
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
174
Blastp_CBE
57.20
38%
2
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[4-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
-
K
E
-
I
L
-
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
DVTGGGSF
S
A
E
-
E
V
----
Q
-------
E
-
L
--
R
-----
E
----
A
-----
T
L
K
-------
E
V
D
I
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
-------
L
V
F
D
L
M
K
K
G
E
L
-
F
D
Y
L
T
--
E
--
K
-
V
----
T
---
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
--
C
------
Q
-----
L
---
D
PG
E
---
K
---
L
R
-
E
-
V
C
G
T
P
S
Y
L
A
P
E
I
---
I
------
E
CSMNDN
H
P
G
-----
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
-
R
----
K
-------
Q
-
M
L
-----
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
-
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
----
T
A
E
E
-----
A
L
A
H
P
F
-------------------------------------------------------------------------------------------------------
113
Blastp_CBE
57.18
38%
2
- C1 -
-
6AAR
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
-------------------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
FG
N
---
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
543
Blastp_CBE
57.14
35%
-36
- C1 -
-
1RE8
2
KAPCA_MOUSE
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
536
Blastp_CBE
57.10
35%
-36
- C1 -
-
3OW3
1
KAPCA_MOUSE
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
483
Blastp_CBE
57.10
36%
-33
- C1 -
-
5UZK
1
KAPCA_HUMAN
A:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
539
Blastp_CBE
57.01
35%
-40
- C1 -
-
3IDB
1
KAPCA_MOUSE
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
540
Blastp_CBE
56.97
35%
-35
- C1 -
-
3FJQ
1
KAPCA_MOUSE
E:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
518
Blastp_CBE
56.94
36%
-32
- C1 -
-
5M0C
2
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
145
Blastp_CBE
56.90
39%
-11
- C1 -
-
3Q5I
1
?
A:
[31-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
-
K
---
I
G
---
E
S
Y
F
K
-
V
R
-
K
L
-
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
--------
K
K
-------------------KF
H
-----
E
----
E
-----
I
Y
N
-------
E
I
S
L
L
K
S
L
-
D
-
H
-
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
----
F
Y
-------
L
V
T
E
F
Y
E
G
G
E
L
-
F
E
Q
I
I
--
N
--
R
-
H
----
K
---
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
-
E
N
K
N
S
L
L
N
I
K
I
V
D
F
G
L
S
--
S
------
F
-----
F
SK-
D
--
Y
---
K
---
L
R
-
D
-
R
L
G
T
A
Y
Y
I
A
P
E
V
---
L
------
K
------
K
K
------
Y
-
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
-
G
-
G
Q
N
--
D
-------
Q
-
D
I
-----
I
-
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
-
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
----
T
A
E
E
-----
A
L
N
S
R
W
-
I
-----------------------------------------------------------------------------------------------------
368
Blastp_CBE
56.89
35%
-115
- C1 -
-
4PDS
1
RAD53_YEAST
B:
[26-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
E
-
V
V
-
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
------------------------------------------------
V
T
R
-------
E
L
E
V
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
---------
Y
Y
-------
M
V
M
E
F
V
S
G
G
D
L
-
M
D
F
V
A
--
A
--
H
-
G
----
A
---
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
--
E
Q
D
D
P
V
L
V
K
I
T
A
F
G
L
A
--
K
------
V
----------------------------
T
L
A
Y
V
A
P
E
V
---
I
--------------
N
E
-----
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
-
S
T
Q
--
D
-------
Q
--------
L
Y
K
Q
I
G
R
G
S
Y
H
-
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
----
T
A
A
K
-----
A
L
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
507
Blastp_CBE
56.84
36%
-35
- C1 -
-
5N32
3
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
-
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
538
Blastp_CBE
56.59
35%
-42
- C1 -
-
3IDC
1
KAPCA_MOUSE
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
557
Blastp_CBE
56.56
35%
-45
- C1 -
-
4NTT
1
KAPCA_MOUSE
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
416
Blastp_CBE
56.55
36%
-35
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[33-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
DGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
511
Blastp_CBE
56.39
36%
-30
- C1 -
-
5MHI
3
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
35
Blastp_CBE
56.32
42%
-50
- C1 -
-
6BAB
1
KCC2D_MOUSE
D:
[10-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
---
D
E
Y
Q
L
-
F
E
-
E
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
-
K
L
----
S
-------
A
-
R
--
D
-----
H
----
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
-------
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
--
A
--
R
-
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
------
E
-----
V
---
Q
--
G
DQQ
A
---
W
F
-
G
-
F
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
---
W
D
E
--
D
-------
Q
-
H
R
-----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
----
T
A
S
E
-----
A
L
K
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
405
Blastp_CBE
56.29
36%
-38
- C1 -
-
2F7Z
1
KAPCA_BOVIN
E:
[48-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
95
Blastp_CBE
56.25
38%
-38
- C1 -
-
3ZXT
1
DAPK1_HUMAN
A:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
-----------------------------RED--
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
--------------------
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
423
Blastp_CBE
56.19
36%
-42
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[17-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
-
L
R
-
T
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
--------
D
K
T
-
Q
L
----
N
P------
S
-
S
--
L
-----
Q
----
K
-----
L
F
R
-------
E
V
R
I
M
K
G
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
----
L
Y
-------
L
V
M
E
Y
A
S
A
G
E
V
-
F
D
Y
L
V
--
S
--
H
-
G
----
R
---
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
----
D
A
E
A
N
I
K
I
A
D
F
G
F
S
--
N
-----------------------------------
S
P
P
Y
A
A
P
E
L
---
F
------
Q
------
G
K
K
-----
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
---
D
G
H
--
N
-------
L
-
K
E
-----
L
R
E
R
V
L
R
G
K
--
Y
R
V
P
F
Y
---
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
----
T
L
E
Q
-----
I
M
K
D
K
W
-
I
-
N
---------------------------------------------------------------------------------------------------
556
Blastp_CBE
55.98
35%
-45
- C1 -
-
4NTT
1
KAPCA_MOUSE
B:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
508
Blastp_CBE
55.89
36%
-32
- C1 -
-
5N1K
3
KAPCA_CRIGR
A:
[50-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
T
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
P
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
430
Blastp_CBE
55.88
38%
-22
- C1 -
-
4REW
1
AAPK1_HUMAN
A:
[7-395]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
F--
L
R
-
T
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
S
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
211
Blastp_CBE
55.55
35%
-28
- C1 -
-
2WTD
4
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------PAL-
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
---
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
205
Blastp_CBE
55.33
35%
-15
- C1 -
-
4A9R
2
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------PAL-
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
212
Blastp_CBE
55.20
35%
-35
- C1 -
-
2WTC
1
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------PAL-
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
---
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
203
Blastp_CBE
55.14
35%
-16
- C1 -
-
4A9T
4
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------PAL-
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
549
Blastp_CBE
55.09
35%
-40
- C1 -
-
1BKX
1
KAPCA_MOUSE
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
210
Blastp_CBE
54.90
35%
-24
- C1 -
-
2WTI
3
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------PAL-
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
E--
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
204
Blastp_CBE
54.87
35%
-29
- C1 -
-
4A9S
1
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------PAL-
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
---
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
422
Blastp_CBE
54.74
37%
-27
- C1 -
-
6BX6
1
AAPK2_HUMAN
A:
[12-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
V
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
K
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
----
F
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
H
-
G
----
R
---
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
----------------------------------------
N
Y
A
A
P
E
--------------------------
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
E
-
H
V
PT---
L
F
K
K
I
R
G
G
V
F
Y
I
P
----
E
-
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
-------------------------------------------------------------------------------------------------
200
Blastp_CBE
54.61
35%
-34
- C1 -
-
4BDB
10
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------L---
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
E--
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
206
Blastp_CBE
54.46
35%
-18
- C1 -
-
2XM9
1
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------PAL-
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
208
Blastp_CBE
54.23
35%
-3
- C1 -
-
2XBJ
1
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------AL--
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
---
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
197
Blastp_CBE
54.09
35%
-8
- C1 -
-
4BDE
5
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------AL--
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
---
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
535
Blastp_CBE
54.06
35%
-37
- C1 -
-
4DIN
1
KAPCA_MOUSE
A:
[47-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
T
L
-
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
--------
D
K
Q
-
K
V
VKL-
K
-------
Q
-
I
--
E
-----
H
----
T
-----
L
-
N
-------
E
K
R
I
L
Q
A
V
-
N
-
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
-------
M
V
M
E
Y
V
A
G
G
E
M
-
F
S
H
L
R
--
R
--
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
--
K
------
R
-----
V
---
K
--
G
---
R
---
T
W
-
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
------
S
K
G
-----
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
------
D
-------
Q
-
P
I
Q----
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
-----
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
----
G
N
L
K
NGVND
I
K
N
H
K
W
-------------------------------------------------------------------------------------------------------
191
Blastp_CBE
53.96
35%
2
- C1 -
-
4BDK
4
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------AL--
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
369
Blastp_CBE
53.90
35%
-96
- C1 -
-
4PDS
1
RAD53_YEAST
A:
[35-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
E
-
V
--------
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
------------------------------------------------
V
T
R
-------
E
L
E
V
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
---
E
S
----
Y
Y
-------
M
V
M
E
F
V
S
G
G
D
L
-
M
D
F
V
A
--
A
--
H
-
G
----
A
---
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
--
E
Q
D
D
P
V
L
V
K
I
T
A
F
G
L
A
--
K
------
V
------------------------------
A
Y
V
A
P
E
V
---
I
R------------
R
N
E
-----
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
-
S
T
Q
--
D
-------
Q
--------
L
Y
K
Q
I
G
R
G
S
Y
H
-
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
----
T
A
A
K
-----
A
L
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
209
Blastp_CBE
53.62
35%
-24
- C1 -
-
2WTJ
5
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------PAL-
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
E--
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
438
Blastp_CBE
53.58
37%
-24
- C1 -
-
5T5T
2
AAPK1_RAT
A:
[17-400]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
94
Blastp_CBE
53.55
38%
-7
- C1 -
-
3ZXT
1
DAPK1_HUMAN
B:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
---------
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
----------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
------------------
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
----
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
393
Blastp_CBE
53.33
37%
-31
- C1 -
-
6B2E
2
AAPK2_HUMAN
A:
[28-386]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
V
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
K
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
----
F
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
H
-
G
----
R
---
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
E
-
H
V
PT---
L
F
K
K
I
R
G
G
V
F
Y
I
P
----
E
-
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
-
Q
G
-------
L
P
---------------------------------------------------------------------------------------
93
Blastp_CBE
53.26
38%
4
- C1 -
-
3ZXT
1
DAPK1_HUMAN
C:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
---
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
-
R
T
----
K
-------
S
-
S
--
R
-----
R
----
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
-------------------
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
437
Blastp_CBE
53.04
37%
-19
- C1 -
-
5UFU
2
AAPK1_MOUSE (first)
A:
[17-400]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
193
Blastp_CBE
53.04
35%
1
- C1 -
-
4BDI
6
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------AL--
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
GE-
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
202
Blastp_CBE
53.01
35%
-4
- C1 -
-
4A9U
10
CHK2_HUMAN
A:
[11-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
-
A
---
L
R
---
D
E
Y
I
M
-
S
K
-
T
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
K
----------------------------DPAL
N
-----
V
E
T
-------
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
----
Y
Y
-------
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
--
G
--
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
-
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
--
K
------
I
-----
L
---
T
--
S
---
L
---
M
R
-
T
-
L
C
G
T
P
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
-
E
H
R
--
T
-------
Q
-
V
S
-----
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
-----
A
L
R
H
P
W
-
L
-
Q
D
E
D
-------
M
----------------------------------------------------------------------------------------
434
Blastp_CBE
52.65
37%
-20
- C1 -
-
6E4W
2
?
A:
[17-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
474
Blastp_CBE
52.44
37%
-25
- C1 -
-
4CFH
1
AAPK1_RAT
A:
[34-352]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
424
Blastp_CBE
52.27
37%
-22
- C1 -
-
4RER
2
AAPK1_HUMAN
A:
[7-347]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
S
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
435
Blastp_CBE
52.25
37%
-18
- C1 -
-
6E4U
2
AAPK1_RAT
A:
[17-403]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
441
Blastp_CBE
52.04
37%
-16
- C1 -
-
4QFR
2
?
A:
[17-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
442
Blastp_CBE
52.02
37%
-19
- C1 -
-
4QFG
1
A:
[17-403]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
92
Blastp_CBE
52.01
38%
-11
- C1 -
-
3ZXT
1
DAPK1_HUMAN
D:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
---
D
Y
Y
D
T
-
G
E
-
E
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-------------------------------------------VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
-------
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
--
E
--------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
------
K
-----
I
---
D
------------------
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
D
--
T
-------
K
-
Q
E
-----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
-----
S
L
Q
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
440
Blastp_CBE
51.86
37%
-22
- C1 -
-
4QFS
2
AAPK1_RAT
A:
[17-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
439
Blastp_CBE
51.77
37%
-19
- C1 -
-
5KQ5
2
?
A:
[17-405]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
436
Blastp_CBE
51.15
37%
-15
- C1 -
-
6E4T
2
?
A:
[17-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
I
L
-
G
D
-
T
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
--------
N
R
Q
-
K
I
----
R
-------
S
-
L
--
D
-----
V
----
V
GK---
I
R
R
-------
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
-------
M
V
M
E
Y
V
S
G
G
E
L
-
F
D
Y
I
C
--
K
--
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
----
K
I
A
D
F
G
L
S
--
N
------
M
-----
M
S--
D
--
G
---
E
---
F
L
-
R
-
S
C
G
S
P
N
Y
A
A
P
E
V
---
I
------
S
------
G
R
L
-----
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----
D
--
D
-------
D
-
H
V
PT---
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
L
-
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
----
T
I
K
D
-----
I
R
E
H
E
W
-
F
-
K
Q
D
--------
L
P
K
--------------------------------------------------------------------------------------
371
Blastp_CBE
50.16
35%
-27
- C1 -
-
3KN5
1
B:
[17-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
P
L
-
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
--------
S
K
R
-
M
------------------
E
-----
A
----
N
-----
T
Q
K
-------
E
I
T
A
L
K
L
C
-
E
G
H
-
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
----
T
F
-------
L
V
M
E
L
L
N
G
G
E
L
-
F
E
R
I
K
--
K
--
K
-
K
----
H
---
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
-
I
K
I
I
D
F
G
F
A
--
R
------
L
-----
K
PP-----------------------------------------------
N
G
-----
Y
-
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
S
-
H
D
R
--
S
-------
L
-
T
C
TSAVE
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
-
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
----
K
M
S
G
-----
L
R
Y
N
E
W
-
L
-
Q
D
--------------------------------------------------------------------------------------------------
338
Blastp_CBE
49.77
38%
17
- C1 -
-
2JBO
1
MAPK2_HUMAN
A:
[13-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
DR
G
--
D
-
Q
----
A
---
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
------
T
--------------------------
C
Y
T
P
Y
Y
V
A
P
E
V
---
L
------
G
------
P
E
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
LA
I
-------
S
-
P
G
-----
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
372
Blastp_CBE
49.64
35%
-41
- C1 -
-
3KN5
1
KS6A5_HUMAN
A:
[17-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
P
L
-
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
--------
S
K
R
-
M
------------------
E
-----
A
----
N
-----
T
Q
K
-------
E
I
T
A
L
K
L
C
-
E
G
H
-
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
----
T
F
-------
L
V
M
E
L
L
N
G
G
E
L
-
F
E
R
I
K
--
K
--
K
-
K
----
H
---
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
-
I
K
I
I
D
F
G
F
A
--
R
------
L
-----
K
PP-----------------------------------------------
N
G
-----
Y
-
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
------------------
C
TSAVE
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
-
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
----
K
M
S
G
-----
L
R
Y
N
E
W
-
L
-
Q
D
--------------------------------------------------------------------------------------------------
324
Blastp_CBE
48.92
38%
11
- C1 -
-
2PZY
1
MAPK2_HUMAN
C:
[11-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
DR
G
--
D
-
Q
----
A
---
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
-----------------------------------
T
P
Y
Y
V
A
P
E
V
---
L
------
G
------
P
E
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
LA
I
-------
S
-
P
G
-----
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
325
Blastp_CBE
48.84
38%
7
- C1 -
-
2PZY
1
MAPK2_HUMAN
B:
[11-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
DR
G
--
D
-
Q
----
A
---
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
-----------------------------------
T
P
Y
Y
V
A
P
E
V
---
L
------
G
------
P
E
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-----------------
G
-----
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
326
Blastp_CBE
48.24
38%
10
- C1 -
-
2PZY
1
MAPK2_HUMAN
A:
[11-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
DR----------
A
---
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
-----------------------------------
T
P
Y
Y
V
A
P
E
V
---
L
------
G
------
P
E
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
LA
I
-------
S
-
P
G
-----
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
367
Blastp_CBE
47.92
38%
4
- C1 -
-
3I7C
1
?
A:
[22-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
I
---
F
S
---
D
R
Y
K
G
-
Q
R
-
V
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
-
Q
V
----
K
-------
Q
-
K
TD
K
-----
E
----
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
K
L
Y
-
E
F
F
E
D
K
G
Y
----
F
Y
-------
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
--
S
--
R
-
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
-
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
------
H
-----
F
---
E
--
A
---
S
---
K
K
-
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
---
L
------
H
------
G
T
------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
-
A
----
N
-------
E
-
Y
D
-----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
--
L
T
Y
V
P
S
R
I
----
S
A
R
D
-----
A
L
D
H
E
W
-
I
-
Q
---------------------------------------------------------------------------------------------------
363
Blastp_CBE
46.89
38%
10
- C1 -
-
1NY3
1
MAPK2_HUMAN
A:
[51-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
D----------------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
------
T
-----
S
---
H
-------------------
P
Y
Y
V
A
P
E
V
---
L
------
G
------
P
E
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
--
S
----------------G----
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
370
Blastp_CBE
45.78
38%
9
- C1 -
-
3KA0
1
MAPK2_HUMAN
A:
[5-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
D----------------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
---------------------------------------------------------------
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
-------------------G----
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
268
Blastp_CBE
44.85
38%
-9
- C1 -
-
3FXW
1
MAPK3_HUMAN
A:
[26-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
---
D
D
Y
Q
L
-
S
K
Q
V
L
-
G
L
G
V
-
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--------
Y
D
S
P
K
A
----
R
-------
Q
-
E
V-
D
-----
H
----
H
-----
W
Q
A
-------
S
G
G
----------
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
GKRC
L
L
-------
I
I
M
E
C
M
E
G
G
E
L
-
F
S
R
I
Q
--
E
R-
D
-
Q
----
A
---
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
--
K
E-------------------------------------------------------------
E
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-----------------------------------
G
F
P
N
P
E
W
S
-
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
----
T
I
T
Q
-----
F
M
N
H
P
W
-
I
-
N
---------------------------------------------------------------------------------------------------
111
Blastp_CBE
44.57
37%
4
- C1 -
-
2J90
2
DAPK3_HUMAN
A:
[20-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
-
M
---
V
E
---
D
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
--------
K
K
R
-
R
L
----
S
-------
S
-
R
--
R
-----
G
----
V
SREE-
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
--
A
---------------
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
I
A
-
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
343
Blastp_CBE
44.55
38%
2
- C1 -
-
3R2Y
1
MAPK2_HUMAN
A:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
D----------------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
------
T
----------------------------------------------------------------
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
------------------------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
342
Blastp_CBE
44.46
38%
20
- C1 -
-
3R30
1
MAPK2_HUMAN
A:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
-
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
D----------------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
------
T
------------------------------------------------------
P
E
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
--
S
----------------G----
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
269
Blastp_CBE
43.99
38%
-12
- C1 -
-
3FHR
1
MAPK3_HUMAN
A:
[26-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
---
D
D
Y
Q
L
-
S
K
Q
V
L
-
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--------
Y
D
S
P
K
A
----
R
-------
Q
-
E
V-
D
-----
H
----
H
-----
W
Q
A
-------
S
G
G
----------
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
GKRC
L
L
-------
I
I
M
E
C
M
E
G
G
E
L
-
F
S
R
I
Q
--
E
R-
D
-
Q
----
A
---
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
--
K
E-----
T
-------------------------------------------------------
E
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-----------------------------------
G
F
P
N
P
E
W
S
-
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
----
T
I
T
Q
-----
F
M
N
H
P
W
-
I
-
N
---------------------------------------------------------------------------------------------------
110
Blastp_CBE
43.04
37%
-4
- C1 -
-
2J90
3
DAPK3_HUMAN
B:
[27-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
E
M
-
G
E
-
E
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
----
K
E
Y
A
A
K
F
I
--------
K
K
R
-
R
L
----
S
-------
S
-
R
--
R
-----
G
----
V
SREE-
I
E
R
-------
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
-------
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
--
E
--
K
-
E
--------
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
------
K
-----
I
---
E
--
A
GN-
E
---
F
K
-
N
-
I
F
G
T
P
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
-
E
-
T
--
K
-------
Q
-
E
T
-----
L
-
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
I
A
-
Q
-----
S
L
E
H
S
W
-
I
-----------------------------------------------------------------------------------------------------
263
Blastp_CBE
42.87
38%
-1
- C1 -
-
3R1N
1
MAPK3_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
---
D
D
Y
Q
L
-
S
K
-
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--------
Y
D
S
P
K
A
----
R
-------
Q
-
E
V-
D
-----
H
----
H
-----
W
Q
A
-------
S
G
G
----------
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
GKRC
L
L
-------
I
I
M
E
C
M
E
G
G
E
L
-
F
S
R
I
Q
--
E
RG-------
A
---
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
--
K
E-----
T
-----
T
------------------------------------------------
P
E
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
----------------------------------
Y
G
F
P
N
P
E
W
S
-
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
----
T
I
T
Q
-----
F
M
N
H
P
W
-
I
-
N
---------------------------------------------------------------------------------------------------
358
Blastp_CBE
42.82
38%
21
- C1 -
-
2P3G
1
MAPK2_HUMAN
X:
[7-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
DR
G
--
D
-
Q
----
A
---
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
------
T
-----
S
--------------------------------------------------
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
--
S
----------------------------
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
356
Blastp_CBE
41.58
38%
28
- C1 -
-
3FYK
1
MAPK2_HUMAN
X:
[7-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
DR
G
--
D
-
Q
----
A
---
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
------
T
-----
S
--------------------------------------------------
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
--
S
----------------------------
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
357
Blastp_CBE
41.56
38%
20
- C1 -
-
3FYJ
1
MAPK2_HUMAN
X:
[7-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
I
K
K
N
A
---
I
I
---
D
D
Y
K
V
T
S
Q
-
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
D
C
P
K
A
----
R
-------------------------------
R
-------
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
---
D
V
Y
E
N
----
L
Y
AGRKCLL
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
DR
G
--
D
-
Q
----
A
---
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
-
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
KE
T
------
T
-----
S
--------------------------------------------------
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
--
S
----------------------------
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
----
T
I
T
E
-----
F
M
N
H
P
W
-
I
-----------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------