@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DCLK3_HUMAN: (2021-11-22 )
MGKEPLTLKSIQVAVEELYPNKARALTLAQHSRAPSPRLRSRLFSKALKGDHRCGETETPKSCSEVAGCKAAMRHQGKIPEELSLDDRARTQKKWGRGKWEPEPSSKPPREATLEERHARGEKHLGVEIEKTSGEIIRCEKCKRERELQQSLERERLSLGTSELDMGKGPMYDVEKLVRTRSCRRSPEANPASGEEGWKGDSHRSSPRNPTQELRRPSKSMDKKEDRGPEDQESHAQGAAKAKKDLVEVLPVTEEGLREVKKDTRPMSRSKHGGWLLREHQAGFEKLRRTRGEEKEAEKEKKPCMSGGRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTVKRQKQVSPSSEGHFRSQHKRVVEQVS
Atome Classification :
(269 SA)
---.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.....-.-.--350----------........360.......370.......380.......-----390------.---..----.------.--.-----.---.----.400.......--410........420....----...430.......440.--.-.----..----.----.450.......460.......470.......480-....-...490.......500..--.--.-----.---.--.-----510..---......520..---.------....---530........540.......550.------...--..--.560.......570.......580.......590.......600-----.......610.-......620...-------------....---630.......640......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MGKEPL
T
L
K
S
I
Q
V
A
V
E
E
LYPNKA
R
A
L
T
L
A
Q
HSRAP
S
P
R
L
R
S
R
L
F
S
K
A
LKGDHRCGETETP
K
S
C
S
E
V
A
G
C
K
A
A
M
R
HQGKIPEELSL
D
D
R
A
R
T
Q
K
KWGRGKWEPEPSSKPP
R
E
A
T
L
E
E
R
HARGEKHL
G
V
E
I
EKTSG
E
I
I
R
C
E
K
C
K
R
E
R
E
L
Q
Q
S
L
E
R
E
R
L
SLGTSELDMGKG
P
M
Y
D
V
E
K
L
V
R
T
R
S
CRRSPEANPASGEEGWKGDSHRSSPRN
P
T
Q
E
L
RRPSKSMDKKEDRGPE
D
Q
E
S
H
A
Q
G
A
A
K
A
K
K
D
L
V
E
VLPV
T
E
E
G
L
R
E
V
K
K
DTRPMSRSKHG
G
W
L
L
R
E
H
Q
A
G
F
E
K
L
R
R
TRGE
E
K
E
A
E
K
EKKPCMSGG
R
R
M
TLRDDQPAKLEKEPKTRPEENKPERPSGRKPR
P
M
G
I
-
I
-
A
--
A
N
-----------
V
E
K
H
YETG
R
V
IGDG
N
F
A
V
V
K
E
C
R
H
R
E
T
R
Q
A
Y
A
M
K
I
I
D
K
-----S--------R---LK----G------K--E-----D---M----VDS
E
I
L
I
I
QSL--S-HP
N
I
V
K
L
H
E
V
Y
ETD
M
E
----
I
Y
L
I
L
E
YVQGG
D
L
F
D
A
I
--
I
-
E
----SV----K----FPEP
D
A
A
L
M
I
M
D
L
C
K
A
L
V
H
MH
D
K
S
I
V
HRDLKPE
N
-
L
L
V
Q-RNEDKS
T
T
L
K
L
A
D
F
G
L
A
K
--
H
--
V
-----
V
---
R
--
P
-----
I
F
-
T
V---CGTP
T
Y
V
A
P
E
I
---
L
------SEKG---Y-
G
L
E
V
D
M
W
A
A
G
V
I
L
Y
I
L
L
CGFPPF------RSP--ER--
D
Q
D
E
L
F
N
I
I
Q
LGHFEFLP
P
Y
WD
N
I
S
D
A
A
K
D
L
V
S
R
L
LVVDPKKR
Y
-----
T
A
H
Q
V
L
QHPWI-ETAGKTN
T
V
K
R
Q
-------------KQVS---PSSEG
H
F
R
S
Q
H
K
R
V
V
E
QVS
2
PsiBlast_PDB
84.45
56%
-136
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[13-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
P
--
A
T
-----------
I
T
E
R
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
-----
S
--------
K
---
C
R
----
G
------
K
--
E
-----
H
---
M
----
I
Q
N
E
V
S
I
L
R
R
V
--
K
-
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
--
T
-
S
----
T
N
----
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
V
Y
-
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
T
--
I
--
V
-----
D
---
G
--
P
-----
L
Y
-
T
V
---
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
E
T
G
---
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
G
S
------
D
Q
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
L
E
H
P
W
V
----------------------------------------------------
573
HHSearch
82.85
56%
-133
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[17-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
E
R
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
-----
S
--------
K
---
C
R
----
G
------
K
--
E
-----
H
---
M
----
I
Q
N
E
V
S
I
L
R
R
V
--
K
-
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
--
T
-
S
----
T
N
----
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
V
Y
-
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
T
--
I
--
V
-----
D
---
G
--
P
-----
L
Y
-
T
V
---
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
E
T
G
---
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
G
S
------
D
Q
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
L
E
H
P
W
V
-
N
--------------------------------------------------
22
Blastp_CBE
82.47
56%
-133
- C1 -
-
5JZN
1
B:
[13-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
P
--
A
T
-----------
I
T
E
R
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
-----
S
--------
K
---
C
R
----
G
------
K
--
E
-----
H
---
M
----
I
Q
N
E
V
S
I
L
R
R
V
--
K
-
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
--
T
-
S
----
T
N
----
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
V
Y
-
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
T
--
I
--
V
-----
D
---
G
--
P
-----
L
Y
-
T
V
---
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
E
T
G
---
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
G
S
-------
Q
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
L
E
H
P
W
V
----------------------------------------------------
21
Blastp_CBE
80.85
54%
-138
- C1 -
-
5JZJ
1
B:
[30-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
P
--
A
T
-----------
I
T
E
R
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
-----
S
--------
K
---
C
R
----
G
------
K
--
E
-----
H
---
M
----
I
Q
N
E
V
S
I
L
R
R
V
--
K
-
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
--
T
-
S
----
T
N
----
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
V
Y
-
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
T
--
I
--
V
-----
D
---
G
--
P
-----
L
Y
-
T
V
---
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
E
T
G
---
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
----------
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
L
E
H
P
W
V
----------------------------------------------------
578
HHSearch
80.10
56%
-136
- C1 -
-
5JZJ
1
B:
[34-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
E
R
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
-----
S
--------
K
---
C
R
----
G
------
K
--
E
-----
H
---
M
----
I
Q
N
E
V
S
I
L
R
R
V
--
K
-
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
--
T
-
S
----
T
N
----
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
V
Y
-
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
T
--
I
--
V
-----
D
---
G
--
P
-----
L
Y
-
T
V
---
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
E
T
G
---
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
----------
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
L
E
H
P
W
V
-
N
--------------------------------------------------
25
Blastp_CBE
77.62
43%
-157
- C1 -
-
6T6F
1
?
A:
[9-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
E
D
-----------
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
-----
K
--------
A
---
L
K
----
G
------
K
--
E
-----
S
---
S
----
I
E
N
E
I
A
V
L
R
K
I
--
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
V
-
E
----
K
G
----
F
----
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
--
S
Q
D
E
E
S
K
I
M
I
S
D
F
G
L
S
------------------------------------
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
P
---
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
D
E
--
N
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
---
A
G
D
T
---------------------------------------------
24
Blastp_CBE
75.31
43%
-153
- C1 -
-
6T6F
1
?
B:
[9-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
E
D
-----------
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
-----
K
--------
A
---
L
K
----
G
------
K
--
E
-----
S
---
S
----
I
E
N
E
I
A
V
L
R
K
I
--
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
V
-
E
----
K
G
----
F
----
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
--
S
Q
D
E
E
S
K
I
M
I
S
D
F
G
--------------------------------------
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
P
---
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
D
E
--
N
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
---
A
G
D
T
---------------------------------------------
563
Fugue
74.82
23%
-9
- C1 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-533]
-----
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
-------------------
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
-------------
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
---------------------------------------------------------------------------------------
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
--------------------------------------------------------
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
----------------------------------------
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
-----
K
--------
R
---
L
K
KR--
K
------
G
--
Y
-----
Q
---
G
----
A
M
V
E
K
K
I
L
A
K
V
--
H
-
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
----
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
--
Y
-
N
----
V
D
----
E
DNPG
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
-
V
L
L
-----
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
--
E
--
L
-----
K
AGQ
T
--
K
-----
T
K
-
G
Y
---
A
G
T
P
G
F
M
A
P
E
L
---
L
------
L
G
E
E
---
Y
-
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
------
R
A
R
GE
K
V
--
E
N
K
E
L
K
Q
R
V
L
E
Q
A
----
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
GFRDG
S
C
D
G
L
R
T
H
P
L
F
-
R
D
I
S
W
R
Q
L
E
A
G
M
LTPPFVPDSRTVY
A
K
N
G
---
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
559
Fugue
74.77
24%
31
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
KAR
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
---------
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
---------------------------------
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
--------------------------------------------------------------------------------------------
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
--------------------------------------------------------------------------
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
-----
K
--------
R
---
I
K
KR--
K
------
G
--
E
-----
A
---
M
----
A
L
N
E
K
Q
I
L
E
K
V
--
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
----
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
YH
M
-
G
----
Q
A
----
G
----
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
-
I
L
L
-----
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
--
H
--
V
-----
P
EG-
Q
--
T
-----
I
K
-
G
R
---
V
G
T
V
G
Y
M
A
P
E
V
---
V
------
K
N
E
R
---
Y
-
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
------
Q
Q
R
--
K
K
KI
K
R
E
E
V
E
R
L
V
K
E
V
P
----
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
GCRGG
S
A
R
E
V
K
E
H
P
L
F
-
K
K
L
N
F
K
R
L
G
A
G
M
-------------
L
E
P
P
FKP
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
1
PsiBlast_PDB
73.81
54%
-46
- C1 -
-
5JZJ
2
DCLK1_HUMAN
A:
[22-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
E
E
G
F
Q
I
-
P
--
A
T
-----------
I
T
E
R
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
-----
S
--------
K
---
C
R
----
G
------
K
--
E
-----
H
---
M
----
I
Q
N
E
V
S
I
L
R
R
V
--
K
-
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
--
T
-
S
----
T
N
----
K
----
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
V
Y
-
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
T
--
I
--
V
-----
D
---
G
--
P
-----
L
Y
-
T
V
---
C
G
T
P
T
Y
V
A
P
E
I
---
I
------
A
E
T
G
---
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
G
S
--------
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
L
E
H
P
W
V
----------------------------------------------------
9
PsiBlast_PDB
73.66
43%
-159
- C1 -
-
4FG7
1
KCC1A_HUMAN
A:
[13-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
E
D
-----------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
---------------------------------------------
S
----
M
E
N
E
I
A
V
L
H
K
I
--
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
V
-
E
----
K
G
----
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
-
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
K
-----
M
-----
E
---
D
--
P
--------------
G
T
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
D
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
---
A
------------------------------------------------
280
Blastp_CBE
72.52
38%
-154
- C1 -
-
4BFM
1
MELK_MOUSE
A:
[9-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
A
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
V
K
T
E
I
D
A
L
K
S
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
D
-
E
N
H
----
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
----------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
E
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
L
L
N
H
P
W
V
----------------------------------------------------
6
PsiBlast_PDB
72.29
43%
-140
- C1 -
-
4FG9
1
KCC1A_HUMAN
A:
[13-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
E
D
-----------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----
E
--------------------------------------------
E
N
E
I
A
V
L
H
K
I
--
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
V
-
E
----
K
G
----
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
-
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
---------------------------------------
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
P
---
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
D
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
L
D
K
N
I
-------------
H
Q
------------------------
4
PsiBlast_PDB
72.08
43%
-160
- C1 -
-
2JC6
1
KCC1D_HUMAN
A:
[17-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
E
D
-----------
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
-----
K
--------
A
-------------------------
S
---
S
----
I
E
N
E
I
A
V
L
R
K
I
--
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
V
-
E
----
K
G
----
F
----
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
--
S
Q
D
E
E
S
K
I
M
I
S
-----------------------------------------
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
P
---
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
D
E
--
N
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
---
A
G
D
T
---------------------------------------------
319
Blastp_CBE
71.70
38%
-160
- C1 -
-
4BKY
1
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
------------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
----------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
23
Blastp_CBE
71.64
43%
-155
- C1 -
-
2JC6
1
KCC1D_HUMAN
C:
[17-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
E
D
-----------
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
-----
K
--------
A
-----------------------------
S
----
I
E
N
E
I
A
V
L
R
K
I
--
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
V
-
E
----
K
G
----
F
----
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
Y
--
S
Q
D
E
E
S
K
I
M
I
S
-----------------------------------------
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
P
---
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
D
E
--
N
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
A
R
H
P
W
I
---
A
G
D
T
---------------------------------------------
49
Blastp_CBE
71.60
44%
0
- C- -
-
3F5U
1
DAPK1_HUMAN
A:
[8-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
101
Blastp_CBE
71.45
43%
0
- C- -
-
3GU8
1
DAPK1_HUMAN
A:
[8-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
100
Blastp_CBE
71.45
43%
0
- C- -
-
3GUB
1
DAPK1_HUMAN
A:
[8-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
62
Blastp_CBE
71.32
44%
0
- C- -
-
1IG1
1
DAPK1_HUMAN
A:
[7-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
281
Blastp_CBE
71.25
38%
-155
- C1 -
-
4CQG
1
MELK_MOUSE
A:
[9-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
A
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
V
K
T
E
I
D
A
L
K
S
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
D
-
E
N
H
----
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
----------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
E
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
L
L
N
H
P
W
V
----------------------------------------------------
3
PsiBlast_PDB
71.11
44%
-114
- C1 -
-
2W4O
1
KCC4_HUMAN
A:
[54-342]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
-----------------------------------------------------
I
G
V
L
L
R
L
--
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
----
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
--
V
-
E
----
K
G
----
Y
----
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
A
--
T
P
A
P
D
A
P
L
K
I
A
D
F
-------------------------------------
G
T
P
G
Y
C
A
P
E
I
---
L
------
R
G
C
A
---
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
------
Y
D
---
E
R
--
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
-----
T
T
F
Q
A
L
Q
H
P
W
V
--
T
G
K
A
A
N
F
V
H
M
D
-------------
T
A
Q
K
---
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
-
8
PsiBlast_PDB
70.90
43%
-144
- C1 -
-
4FG8
1
KCC1A_HUMAN
A:
[13-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
E
D
-----------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--------------------------------------------------
E
N
E
I
A
V
L
H
K
I
--
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
V
-
E
----
K
G
----
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
-
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
--------------------------------------
T
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
P
---
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
D
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
L
D
K
N
I
-------------
H
Q
------------------------
572
HHSearch
70.80
39%
-42
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
A---
R
------
D
--
H
-----
Q
---
K
----
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
-
S
K
-
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
-----
Q
---
G
--
D
QQA--
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
E
--
D
Q
----
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
-
C
Q
R
----
S
M
M
H
R
-------------
Q
E
T
V
---
D
C
L
K
---------------
17
PsiBlast_PDB
70.63
41%
-32
- C1 -
-
6BAB
2
KCC2D_MOUSE
A:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
11
PsiBlast_PDB
70.53
41%
-40
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[6-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
----
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
35
Blastp_CBE
70.39
41%
-35
- C1 -
-
2VN9
2
KCC2D_HUMAN
A:
[6-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
317
Blastp_CBE
70.29
38%
-159
- C1 -
-
4BL1
1
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
---------------
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
34
Blastp_CBE
69.87
41%
-34
- C1 -
-
2VN9
1
KCC2D_HUMAN
B:
[6-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
16
PsiBlast_PDB
69.71
41%
-31
- C1 -
-
6AYW
2
KCC2D_HUMAN
A:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
307
Blastp_CBE
69.58
38%
-164
- C1 -
-
5TWY
1
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
----------------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
----------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
298
Blastp_CBE
69.49
38%
-120
- C1 -
-
5TVT
1
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
-----------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
29
Blastp_CBE
69.33
41%
-29
- C1 -
-
6BAB
1
KCC2D_MOUSE
D:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
33
Blastp_CBE
68.98
41%
-28
- C1 -
-
5VLO
2
KCC2D_HUMAN
B:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
32
Blastp_CBE
68.91
41%
-28
- C1 -
-
6AYW
2
KCC2D_HUMAN
B:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
30
Blastp_CBE
68.85
41%
-30
- C1 -
-
6BAB
2
KCC2D_MOUSE
C:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
318
Blastp_CBE
68.33
38%
-166
- C1 -
-
4BKZ
1
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
---------------
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
----------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
-------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
15
PsiBlast_PDB
68.18
41%
-34
- C1 -
-
5VLO
2
KCC2D_HUMAN
A:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
313
Blastp_CBE
68.11
38%
-125
- C1 -
-
5MAH
2
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
-----L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
308
Blastp_CBE
68.11
38%
-124
- C1 -
-
5TWL
1
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
----------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
345
Blastp_CBE
68.08
37%
-126
- C1 -
-
4UMQ
1
MELK_HUMAN
A:
[29-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
----------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
T
A
A
A
L
V
A
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
105
Blastp_CBE
68.06
41%
-61
- C1 -
-
3SOA
1
KCC2A_HUMAN
A:
[7-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
-----------
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
----
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
-
L
L
L
A
--
S
K
L
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
EGE--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
-----
T
A
A
E
A
L
K
H
P
W
I
----------------------------------------------------
40
Blastp_CBE
68.00
40%
-38
- C1 -
-
3BHH
1
KCC2B_HUMAN
B:
[6-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
E
A
---
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
316
Blastp_CBE
67.93
38%
-126
- C1 -
-
5M5A
1
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
----------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
-----L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
41
Blastp_CBE
67.81
40%
-38
- C1 -
-
3BHH
1
KCC2B_HUMAN
A:
[6-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
E
A
---
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
10
PsiBlast_PDB
67.68
43%
-111
- C1 -
-
2JAM
3
KCC1G_HUMAN
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
----------------------------------------
S
---
S
----
L
E
N
E
I
A
V
L
K
K
I
--
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
L
-
E
----
R
G
----
V
----
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
L
-
T
P
E
E
N
S
K
I
M
-
I
T
D
F
G
L
S
K
--
M
--
E
-----
Q
---
N
--
G
-----
I
M
S
T
A
---
C
G
T
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
P
---
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
E
E
--
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
E
K
A
L
S
H
P
W
I
-
D
--------------------------------------------------
344
Blastp_CBE
67.60
37%
-129
- C1 -
-
4UMR
1
MELK_HUMAN
A:
[29-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
----------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
T
A
A
A
L
V
A
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
321
Blastp_CBE
67.56
38%
-128
- C1 -
-
5IHC
1
MELK_HUMAN
A:
[8-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
-------------------------------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
315
Blastp_CBE
67.51
38%
-121
- C1 -
-
5MAF
2
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
------------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
-----L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
336
Blastp_CBE
67.47
38%
-130
- C1 -
-
4UMT
2
MELK_HUMAN
A:
[29-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
----------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
T
A
A
A
L
V
A
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
309
Blastp_CBE
67.46
38%
-145
- C1 -
-
6GVX
2
MELK_HUMAN
B:
[13-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---------
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
--
P
--------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
-------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
28
Blastp_CBE
67.33
43%
-112
- C1 -
-
2JAM
3
KCC1G_HUMAN
B:
[4-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
T
N
-----------
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
----------------------------------------
S
---
S
----
L
E
N
E
I
A
V
L
K
K
I
--
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
L
-
E
----
R
G
----
V
----
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
L
-
T
P
E
E
N
S
K
I
M
-
I
T
D
F
G
L
S
K
--
M
--
E
-----
Q
---
N
--
G
-----
I
M
S
T
A
---
C
G
T
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
P
---
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
E
E
--
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
E
K
A
L
S
H
P
W
I
-
D
--------------------------------------------------
320
Blastp_CBE
67.26
38%
-118
- C1 -
-
5K00
1
MELK_HUMAN
A:
[8-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
--
P
---------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
26
Blastp_CBE
67.20
44%
-102
- C1 -
-
4FG9
1
KCC1A_HUMAN
B:
[14-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-----------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
----------------------------------------------------
E
I
A
V
L
H
K
I
--
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
V
-
E
----
K
G
----
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
-
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
-----------------------V----
L
S
-
T
A
---
C
G
T
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
P
---
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
D
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
L
D
K
N
I
-------------
H
Q
------------------------
305
Blastp_CBE
67.12
38%
-122
- C1 -
-
5TWZ
1
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
------------------------------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
31
Blastp_CBE
66.95
41%
-27
- C1 -
-
6BAB
2
KCC2D_MOUSE
B:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGD--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
88
Blastp_CBE
66.76
41%
-46
- C1 -
-
5FG8
3
KCC2A_DROME
A:
[15-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
-----
K
--------
K
---
L
T
----
A
------
R
--
D
F----
Q
---
K
----
L
E
R
E
A
R
I
C
R
K
L
--
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
F
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
A
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
-----
Q
GDH
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
K
K
E
P
---
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
P
W
I
----------------------------------------------------
323
Blastp_CBE
66.69
38%
-121
- C1 -
-
5IH9
1
MELK_HUMAN
A:
[8-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
-------------------
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
335
Blastp_CBE
66.51
38%
-125
- C1 -
-
4UMU
1
MELK_HUMAN
A:
[29-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
----------------------------------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
T
A
A
A
L
V
A
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
312
Blastp_CBE
66.51
38%
-127
- C1 -
-
5MAI
2
MELK_HUMAN
A:
[10-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
G
----
S
------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
--------------------------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
89
Blastp_CBE
66.16
40%
-50
- C1 -
-
5HU3
1
KCC2A_DROME
A:
[15-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
-----
K
--------
K
---
L
T
----
A
------
R
--
D
F----
Q
---
K
----
L
E
R
E
A
R
I
C
R
K
L
--
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
F
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
-
L
L
L
A
--
S
K
A
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
-----
Q
GDH
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
K
K
E
P
---
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
P
W
I
----------------------------------------------------
102
Blastp_CBE
66.13
40%
-32
- C1 -
-
2V7O
3
KCC2G_HUMAN
A:
[33-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
-----
K
--------
K
---
L
S
----
A
------
R
--
D
-----
H
---
Q
K---
L
E
R
E
A
R
I
C
R
L
L
--
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
Y
----
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
QGE--
Q
---
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
R
K
D
P
---
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
D
Q
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
-------------
E
T
V
-----------------------
314
Blastp_CBE
65.85
38%
-122
- C1 -
-
5MAG
3
MELK_HUMAN
A:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
------------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
-----L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
27
Blastp_CBE
65.85
44%
-75
- C1 -
-
4FG8
1
KCC1A_HUMAN
B:
[14-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-----------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
---------------------------------------------------
N
E
I
A
V
L
H
K
I
--
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
--
V
-
E
----
K
G
----
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
-
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
G
----------------------GSV--
L
S
-
T
A
---
C
G
T
P
G
Y
V
A
P
E
V
---
L
------
A
Q
K
P
---
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
----
D
E
--
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
---
A
G
D
T
A
L
D
K
N
I
-------------
H
Q
------------------------
190
Blastp_CBE
65.56
37%
7
- C1 -
-
2CKE
1
DAPK2_HUMAN
D:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
RQSRA
S
--------
R
---
R
G
----
V
------
S
--
R
-----
E
---
E
----
I
E
R
E
V
S
I
L
R
Q
V
--
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
Q
----
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
--
E
--
I
EDGVE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
I
T
S
V
S
-
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
N
Q
Q
A
M
V
R
R
-------------
E
S
V
V
---
N
L
E
--
N
F
R
K
Q
Y
V
-------
188
Blastp_CBE
65.46
37%
-98
- C1 -
-
2CN5
1
CHK2_HUMAN
A:
[7-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----
R
--------------------------------------
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
GE---
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
306
Blastp_CBE
65.42
38%
-160
- C1 -
-
5TWY
1
MELK_HUMAN
B:
[10-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
-------------------------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------------------------------
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
322
Blastp_CBE
65.20
38%
-127
- C1 -
-
5IHA
1
MELK_HUMAN
A:
[8-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
----
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
---
L
-------------------------
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
87
Blastp_CBE
65.07
41%
-49
- C1 -
-
5H9B
2
KCC2A_DROME
A:
[15-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
-----
K
--------
K
---
L
T
----
A
------
R
--
D
F----
Q
---
K
----
L
E
R
E
A
R
I
C
R
K
L
--
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
--
V
-
A
----
R
E
----
F
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
-
L
L
L
A
--
S
K
A
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--
E
--
V
-----
Q
GDH
Q
--
A
-----
W
F
-
G
F
---
A
G
T
P
G
Y
L
S
P
E
V
---
L
------
K
K
E
P
---
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
----
D
E
--
D
Q
H
R
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
P
W
I
----------------------------------------------------
287
Blastp_CBE
64.97
38%
-167
- C1 -
-
5TX3
2
MELK_HUMAN
A:
[13-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
-------------------------------------------
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
-----------------------------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
324
Blastp_CBE
64.73
38%
-123
- C1 -
-
5IH8
1
MELK_HUMAN
A:
[8-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
----------------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
------------------
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
S
---
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
192
Blastp_CBE
64.56
37%
8
- C1 -
-
2CKE
1
DAPK2_HUMAN
B:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
RQSRA
S
--------
R
---
R
G
----
V
------
S
--
R
-----
E
---
E
----
I
E
R
E
V
S
I
L
R
Q
V
--
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
Q
----
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
--
E
--
I
EDGVE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
I
T
S
V
S
-
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
N
Q
Q
A
M
V
R
R
-------------
E
S
V
V
---
N
L
E
--
N
F
R
K
Q
Y
V
-------
138
Blastp_CBE
64.21
37%
7
- C1 -
-
2YAA
1
DAPK2_MOUSE
A:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
RQSRA
S
--------
R
---
R
G
----
V
------
C
--
R
-----
E
---
E
----
I
E
R
E
V
S
I
L
R
Q
V
--
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
Q
----
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
--
E
--
I
EDGVE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
I
T
A
V
S
-
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
T
Q
Q
A
M
V
R
R
-------------
E
S
V
V
---
N
L
E
--
N
F
K
K
Q
Y
V
-------
137
Blastp_CBE
64.08
37%
3
- C1 -
-
2YAA
1
DAPK2_MOUSE
B:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
RQSRA
S
--------
R
---
R
G
----
V
------
C
--
R
-----
E
---
E
----
I
E
R
E
V
S
I
L
R
Q
V
--
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
Q
----
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
--
E
--
I
EDGVE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
I
T
A
V
S
-
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
T
Q
Q
A
M
V
R
R
-------------
E
S
V
V
---
N
L
E
--
N
F
K
K
Q
Y
V
-------
118
Blastp_CBE
63.94
39%
-8
- C1 -
-
1QL6
1
PHKG1_RABIT
A:
[17-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
-----
T
GGGSFSAE
E
---
V
Q
----
E
------
L
--
R
-----
E
---
A
----
T
L
K
E
V
D
I
L
R
K
V
--
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
--
T
-
E
----
K
V
----
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
-----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
C
--
Q
--
L
DP---
G
---
E
--
K
-----
L
R
-
S
V
---
C
G
T
P
S
Y
L
A
P
E
I
---
I
ECSMND
N
H
P
G
---
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
----
H
R
--
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
L
A
H
P
F
F
-
Q
--------------------------------------------------
257
Blastp_CBE
63.83
38%
-42
- C1 -
-
3MFU
1
CSKP_HUMAN
A:
[23-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
-----
A
--------
K
---
F
T
----
S
------
S
--
P
-----
G
---
L
STED
L
K
R
E
A
S
I
C
H
M
L
--
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
--
V
-
K
RADA
G
F
----
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
-
V
L
L
A
-
S
K
E
N
-
S
A
P
V
K
L
G
D
F
G
V
A
I
--
Q
--
L
-----
G
---
E
--
S
-----
G
L
-
V
A
GGR
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
R
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
T
-------
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
-
K
--------------------------------------------------
98
Blastp_CBE
63.44
40%
3
- C1 -
-
3BQR
4
DAPK3_HUMAN
A:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
L
S
----
S
------
S
--
R
RGVSR
E
---
E
----
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
EAGN--------
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
-
K
A
I
R
R
R
N
V
-------------------------------------------
172
Blastp_CBE
63.39
37%
-111
- C1 -
-
4BDD
4
CHK2_HUMAN
A:
[7-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------------------
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
-----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
144
Blastp_CBE
63.32
40%
-59
- C1 -
-
3IGO
8
?
A:
[24-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
-----
A
--------
S
---
A
K
----
N
------
K
---T----
S
---
T
----
I
L
R
E
V
E
L
L
K
K
L
--
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
--
I
-
K
----
R
K
----
R
----
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
E
-
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
--
C
--
F
-----
Q
---
Q
NT----------------
T
A
Y
Y
I
A
P
E
V
---
L
-------
R
G
T
---
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
G
----
K
--
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
-
Q
--------------------------------------------------
99
Blastp_CBE
63.30
40%
2
- C1 -
-
3BHY
1
DAPK3_HUMAN
A:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
L
S
----
S
------
S
--
R
RGVSR
E
---
E
----
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
E------------------
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
-
K
A
I
R
R
R
N
V
-------------------------------------------
258
Blastp_CBE
63.28
38%
-42
- C1 -
-
3MFS
1
CSKP_HUMAN
A:
[23-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
-----
A
--------
K
---
F
T
----
S
------
S
--
P
-----
G
---
L
STED
L
K
R
E
A
S
I
C
H
M
L
--
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
--
V
-
K
RADA
G
F
----
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
-
V
L
L
A
-
S
K
E
N
-
S
A
P
V
K
L
G
D
F
G
V
A
I
--
Q
--
L
-----
G
---
E
--
S
-----
G
L
-
V
A
GGR
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
R
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
T
-------
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
-
K
--------------------------------------------------
193
Blastp_CBE
63.27
37%
10
- C1 -
-
2CKE
1
DAPK2_HUMAN
A:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
RQSRA
S
--------
R
---
R
G
----
V
------
S
--
R
-----
E
---
E
----
I
E
R
E
V
S
I
L
R
Q
V
--
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
Q
----
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
--
E
--
I
EDGVE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
I
T
S
V
S
-
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
N
Q
Q
A
M
V
R
R
-------------
E
S
V
V
---
N
L
E
--
N
F
R
K
Q
Y
V
-------
80
Blastp_CBE
63.25
44%
-5
- C1 -
-
2W4J
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
119
Blastp_CBE
63.19
39%
-9
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[4-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
-----
T
GGGSFSAE
E
---
V
Q
----
E
------
L
--
R
-----
E
---
A
----
T
L
K
E
V
D
I
L
R
K
V
--
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
--
T
-
E
----
K
V
----
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
-----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
C
--
Q
--
L
DP---
G
---
E
--
K
-----
L
R
-
E
V
---
C
G
T
P
S
Y
L
A
P
E
I
---
I
ECSMND
N
H
P
G
---
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
----
H
R
--
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
L
A
H
P
F
F
-
Q
--------------------------------------------------
125
Blastp_CBE
63.09
39%
-10
- C1 -
-
1PHK
1
PHKG1_RABIT
A:
[17-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
-----
T
GGGSFSAE
E
---
V
Q
----
E
------
L
--
R
-----
E
---
A
----
T
L
K
E
V
D
I
L
R
K
V
--
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
--
T
-
E
----
K
V
----
T
----
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
-
I
L
L
-----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
C
--
Q
--
L
DP---
G
---
E
--
K
-----
L
R
-
E
V
---
C
G
T
P
S
Y
L
A
P
E
I
---
I
ECSMND
N
H
P
G
---
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
----
H
R
--
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
L
A
H
P
F
F
-
Q
--------------------------------------------------
66
Blastp_CBE
63.09
44%
-8
- C1 -
-
5AV3
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
-----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
45
Blastp_CBE
63.09
44%
-76
- C1 -
-
3ZXT
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
------------
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
-
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
D-----------------------------
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
428
Blastp_CBE
62.93
35%
-21
- C1 -
-
2OH0
1
KAPCA_BOVIN
E:
[44-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--------
K
VVK
L
K
----
Q
------
I
--
E
-----
H
---
T
----
L
N
-
E
K
R
I
L
Q
A
V
--
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
-
R
----
I
G
----
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
-
L
L
I
-----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
-----
K
---
G
--
R
-----
T
W
-
T
L
---
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
S
K
G
---
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
A
D
--
Q
P
--
I
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
-
P
S
H
F
---
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
-
A
T
T
D
W
I
A
I
Y
Q
R
K
---------------------------------------
69
Blastp_CBE
62.88
44%
-10
- C1 -
-
5AV0
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
-----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
191
Blastp_CBE
62.81
37%
10
- C1 -
-
2CKE
1
DAPK2_HUMAN
C:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
RQSRA
S
--------
R
---
R
G
----
V
------
S
--
R
-----
E
---
E
----
I
E
R
E
V
S
I
L
R
Q
V
--
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
Q
----
K
E
----
S
----
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
--
E
--
I
EDGVE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
I
T
S
V
S
-
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
-
T
P
V
D
N
Q
Q
A
M
V
R
R
-------------
E
S
V
V
---
N
L
E
--
N
F
R
K
Q
Y
V
-------
39
Blastp_CBE
62.77
44%
-6
- C1 -
-
2Y0A
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
310
Blastp_CBE
62.63
38%
-92
- C1 -
-
6GVX
3
MELK_HUMAN
A:
[13-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
--
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------
T
----------------
D
--
L
-----
P
---
R
----
I
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
------------
A
---
K
--
P
KGNK---------
C
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
K
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
259
Blastp_CBE
62.63
38%
-40
- C1 -
-
3MFR
1
CSKP_HUMAN
A:
[23-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
E
L
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
-----
A
--------
K
---
F
T
----
S
------
S
--
P
-----
G
---
L
STED
L
K
R
E
A
S
I
C
H
M
L
--
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
--
V
-
K
RADA
G
F
----
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
-
V
L
L
A
-
S
K
E
N
-
S
A
P
V
K
L
G
D
F
G
V
A
I
--
Q
--
L
-----
G
---
E
--
S
-----
G
L
-
V
A
GGR
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
R
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
T
-------
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
-
K
--------------------------------------------------
36
Blastp_CBE
62.58
44%
-3
- C1 -
-
2W4K
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
81
Blastp_CBE
62.56
44%
-2
- C1 -
-
4TXC
7
DAPK1_HUMAN
A:
[27-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
46
Blastp_CBE
62.49
44%
-3
- C1 -
-
2YAK
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
151
Blastp_CBE
62.44
37%
-95
- C1 -
-
2YIQ
1
CHK2_HUMAN
A:
[3-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------------------------------------
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
GE---
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
126
Blastp_CBE
62.41
39%
-98
- C1 -
-
5O1S
2
A:
[46-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
K
E
D
I
-----
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
K
-----
S
--------
K
---
R
D
----
P
------
T
--
E
-----
E
---
I
-------
E
I
L
L
-
R
Y
G
--
Q
-
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
--
L
-
R
----
Q
K
----
F
----
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
-
I
L
Y
V
-
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
K
--
Q
--
L
-----
R
---
A
--
E
NGL--
L
M
-
T
P
---
C
---
N
F
V
A
P
E
V
---
L
------
E
R
Q
G
---
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A-----
N
G
P
--
D
D
--
T
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
A
L
V
L
R
H
P
W
I
----------------------------------------------------
82
Blastp_CBE
62.37
44%
-10
- C1 -
-
4PF4
6
DAPK1_HUMAN
A:
[9-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
152
Blastp_CBE
62.25
37%
-103
- C1 -
-
2YCS
1
CHK2_HUMAN
A:
[2-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------------------
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
-----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
67
Blastp_CBE
62.25
44%
-9
- C1 -
-
5AV2
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
-----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
74
Blastp_CBE
62.14
44%
-7
- C1 -
-
5AUV
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
-----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
71
Blastp_CBE
62.14
44%
-6
- C1 -
-
5AUY
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
-----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
18
PsiBlast_PDB
62.10
43%
-6
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
431
Blastp_CBE
62.07
35%
-22
- C1 -
-
2F7E
1
KAPCA_BOVIN
E:
[44-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--------
K
VVK
L
K
----
Q
------
I
--
E
-----
H
---
T
----
L
N
-
E
K
R
I
L
Q
A
V
--
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
-
R
----
I
G
----
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
-
L
L
I
-----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
-----
K
---
G
--
R
-----
T
W
-
T
L
---
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
S
K
G
---
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
A
D
--
Q
P
--
I
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
-
P
S
H
F
---
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
-
A
T
T
D
W
I
A
I
Y
Q
R
K
---------------------------------------
72
Blastp_CBE
62.07
44%
-6
- C1 -
-
5AUX
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
-----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
175
Blastp_CBE
62.06
37%
-107
- C1 -
-
4BDA
8
CHK2_HUMAN
A:
[7-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------------------
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
E----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
78
Blastp_CBE
62.06
44%
-0
- C1 -
-
1WVY
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
290
Blastp_CBE
62.02
37%
-86
- C1 -
-
6CK3
1
MKNK2_HUMAN
A:
[20-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
-----
Q
--------
P
---
G
H
----
I
------
R
--
S
-----
R
---
V
----
F
R
E
V
E
M
L
Y
Q
C
Q
--
G
-
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
--
H
-
K
----
R
R
----
H
----
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
C
E
--
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
------------------------------------
G
S
A
E
Y
M
A
P
E
V
VEA
F
------
S
E
E
A
SI-
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-
A
C
--
P
A
--
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
-----
S
A
A
Q
V
L
Q
H
P
W
V
-
Q
G
C
------------------------------------------------
13
PsiBlast_PDB
62.01
43%
-4
- C1 -
-
2XUU
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
A
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
168
Blastp_CBE
61.98
37%
-101
- C1 -
-
4BDH
4
CHK2_HUMAN
A:
[8-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------------------
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
GE---
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
95
Blastp_CBE
61.88
40%
2
- C1 -
-
5A6O
3
DAPK3_HUMAN
A:
[3-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
L
S
----
S
------
S
--
R
RGVSR
E
---
E
----
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
E--------
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
-
K
A
I
------------------------------------------------
75
Blastp_CBE
61.80
44%
-11
- C1 -
-
5AUU
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-------
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
575
HHSearch
61.73
37%
-38
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
-----
A
--------
K
---
F
T
SSPG
L
------
S
--
T
-----
E
---
D
----
L
K
R
E
A
S
I
C
H
M
L
--
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
--
V
-
K
----
R
A
DAGF
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
L
A
-
S
K
-
E
N
S
A
P
V
K
L
G
G
F
G
V
A
I
--
Q
--
L
-----
G
---
E
--
S
GLV--
A
G
-
G
R
---
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
R
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
T
--
K
E
-----
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
-
K
E
R
D
R
Y
A
--------------------------------------------
187
Blastp_CBE
61.74
37%
-103
- C1 -
-
2CN8
1
CHK2_HUMAN
A:
[10-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------------------
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
-----
T
---
S
--
L
-----
M
R
-
T
L
---
C
--
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
-----
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
268
Blastp_CBE
61.73
36%
-54
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
-----
A
--------
K
---
F
T
----
S
------
S
--
P
-----
G
---
L
STED
L
K
R
E
A
S
I
C
H
M
L
--
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
--
V
-
K
RADA
G
F
----
V
----
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
L
A
-
S
K
E
N
-
S
A
P
V
K
L
G
G
F
G
V
A
I
--
Q
--
L
-----
G
---
E
--
S
-----
G
L
-
V
A
GGR
V
G
T
P
H
F
M
A
P
E
V
---
V
------
K
R
E
P
---
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-------
T
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
-
K
--------------------------------------------------
97
Blastp_CBE
61.71
40%
1
- C1 -
-
5A6N
4
DAPK3_HUMAN
A:
[3-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
L
S
----
S
------
S
--
R
RGVSR
E
---
E
----
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
EAGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
-
K
A
I
------------------------------------------------
47
Blastp_CBE
61.69
43%
21
- C1 -
-
4UV0
1
DAPK1_HUMAN
A:
[5-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
F
R
Q
--
E
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
261
Blastp_CBE
61.67
35%
2
- C1 -
-
3Q5I
1
?
A:
[10-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
E
N
L
Y
F
Q
G
-
I
-
A
--
I
N
PGMYVRKKEGK
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
--------------------------------KF
H
-----
E
---
E
----
I
Y
N
E
I
S
L
L
K
S
L
--
D
-
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
----
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
--
I
-
N
----
R
H
----
K
----
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
-
I
L
L
E
--
N
K
N
S
L
L
N
I
K
I
V
D
F
G
L
S
S
--
F
--
F
-----
S
---
K
--
D
YK---
L
R
-
D
R
---
L
G
T
A
Y
Y
I
A
P
E
V
---
L
------
K
K
K
----
Y
-
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
-------
G
G
--
Q
N
--
D
Q
D
-
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
-----
T
A
E
E
A
L
N
S
R
W
I
-
K
K
Y
A
--
N
N
I
N
K
S
-------------
D
Q
------------------------
91
Blastp_CBE
61.67
40%
-5
- C1 -
-
5VJA
2
DAPK3_HUMAN
C:
[3-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
L
S
----
S
----------GVSR-
E
---
E
----
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
-----
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
--
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
EAGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
-
K
A
I
------------------------------------------------
430
Blastp_CBE
61.50
35%
-21
- C1 -
-
2F7X
1
KAPCA_BOVIN
E:
[44-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--------
K
VVK
L
K
----
Q
------
I
--
E
-----
H
---
T
----
L
N
-
E
K
R
I
L
Q
A
V
--
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
-
R
----
I
G
----
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
-
L
L
I
-----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
-----
K
---
G
--
R
-----
T
W
-
T
L
---
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
S
K
G
---
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
A
D
--
Q
P
--
I
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
-
P
S
H
F
---
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
-
A
T
T
D
W
I
A
I
Y
Q
R
K
---------------------------------------
286
Blastp_CBE
61.42
38%
-130
- C1 -
-
5TX3
2
MELK_HUMAN
B:
[13-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
-----
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
--------------------------------------------------
K
T
E
I
E
A
L
K
N
L
--
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
--
I
-
S
----
Q
D
----
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
F
-----
D
E
Y
H
K
L
K
L
I
D
--------------------------------------
G
S
L
A
Y
A
A
P
E
L
---
I
------
Q
G
------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--------
D
--
D
D
--
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
----------------------------------------------------
283
Blastp_CBE
61.27
37%
-42
- C1 -
-
5EAK
1
MARK2_HUMAN
A:
[16-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--------
Q
---
L
N
----
S
------
S
--
S
L----
Q
---
K
----
L
F
R
E
V
R
I
M
K
V
L
--
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
----
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
--
V
-
A
----
H
G
----
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
-----
D
A
D
M
N
I
K
I
A
D
F
G
F
S
-----------------------------
F
---
C
G
S
P
P
Y
A
A
P
E
L
---
F
------
Q
G
K
K
---
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
----
Q
--
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
--
P
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
-
N
V
G
H
E
D
D
E
L
K
-----------------------------------------
427
Blastp_CBE
61.28
35%
-23
- C1 -
-
2OJF
1
KAPCA_BOVIN
E:
[44-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--------
K
VVK
L
K
----
Q
------
I
--
E
-----
H
---
T
----
L
N
-
E
K
R
I
L
Q
A
V
--
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
-
R
----
I
G
----
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
-
L
L
I
-----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
-----
K
---
G
--
R
-----
T
W
-
T
L
---
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
S
K
G
---
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
A
D
--
Q
P
--
I
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
-
P
S
H
F
---
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
-
A
T
T
D
W
I
A
I
Y
Q
R
K
---------------------------------------
92
Blastp_CBE
61.27
40%
9
- C1 -
-
5VJA
2
DAPK3_HUMAN
B:
[3-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
----------------------------------
R
RGVSR
E
---
E
----
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
EAGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
-
K
A
I
------------------------------------------------
65
Blastp_CBE
61.24
44%
-12
- C1 -
-
5AV4
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-------
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
94
Blastp_CBE
61.17
40%
4
- C1 -
-
5A6O
2
DAPK3_HUMAN
B:
[3-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
L
S
----
S
------
S
--
R
RGVSR
E
---
E
----
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
E--------
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
-
K
A
-------------------------------------------------
73
Blastp_CBE
61.13
44%
-8
- C1 -
-
5AUW
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
----------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
289
Blastp_CBE
61.06
37%
-90
- C1 -
-
6CK6
1
MKNK2_HUMAN
A:
[20-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
-----
Q
--------
P
---
G
H
----
I
------
R
--
S
-----
R
---
V
----
F
R
E
V
E
M
L
Y
Q
C
Q
--
G
-
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
--
H
-
K
----
R
R
----
H
----
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
C
E
--
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
------------------------------------
G
S
A
E
Y
M
A
P
E
V
VEA
F
------
S
E
E
A
SI-
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-
A
C
--
P
A
--
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
-----
S
A
A
Q
V
L
Q
H
P
W
V
-
Q
G
C
------------------------------------------------
76
Blastp_CBE
61.02
44%
-8
- C1 -
-
5AUT
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-------
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
282
Blastp_CBE
60.96
37%
-43
- C1 -
-
5EAK
1
MARK2_HUMAN
B:
[16-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--------
Q
---
L
N
----
S
------
S
--
S
L----
Q
---
K
----
L
F
R
E
V
R
I
M
K
V
L
--
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
----
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
--
V
-
A
----
H
G
----
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
-----
D
A
D
M
N
I
K
I
A
D
F
G
-------------------------------
F
---
C
G
S
P
P
Y
A
A
P
E
L
---
F
------
Q
G
K
K
---
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
----
Q
--
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
--
P
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
-
N
V
G
H
E
D
D
E
L
K
-----------------------------------------
516
Blastp_CBE
60.90
35%
-20
- C1 -
-
2UZT
1
KAPCA_BOVIN
A:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--------
K
VVK
L
K
----
Q
------
I
--
E
-----
H
---
T
----
L
N
-
E
K
R
I
L
Q
A
V
--
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
-
R
----
I
G
----
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
-
L
L
I
-----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
-----
K
---
G
--
R
-----
T
W
-
T
L
---
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
S
K
G
---
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
A
D
--
Q
P
--
I
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-
A
T
T
D
W
I
A
I
Y
Q
R
K
---------------------------------------
429
Blastp_CBE
60.90
35%
-24
- C1 -
-
2F7Z
1
KAPCA_BOVIN
E:
[44-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--------
K
VVK
L
K
----
Q
------
I
--
E
-----
H
---
T
----
L
N
-
E
K
R
I
L
Q
A
V
--
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
-
R
----
I
G
----
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
-
L
L
I
-----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
-----
K
---
G
--
R
-----
T
W
-
T
L
---
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
S
K
G
---
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
A
D
--
Q
P
--
I
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
-
P
S
H
F
---
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKN
G
V
N
D
I
K
N
H
K
W
F
-
A
T
T
D
W
I
A
I
Y
Q
R
K
---------------------------------------
288
Blastp_CBE
60.86
37%
-84
- C1 -
-
6CKI
1
MKNK2_HUMAN
A:
[20-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
-----
Q
--------
P
---
G
H
----
I
------
R
--
S
-----
R
---
V
----
F
R
E
V
E
M
L
Y
Q
C
Q
--
G
-
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
--
H
-
K
----
R
R
----
H
----
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
C
E
--
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
------------------------------------
G
S
A
E
Y
M
A
P
E
V
VEA
F
------
S
E
E
A
SI-
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-
A
C
--
P
A
--
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
-----
S
A
A
Q
V
L
Q
H
P
W
V
-
Q
G
C
------------------------------------------------
96
Blastp_CBE
60.80
40%
3
- C1 -
-
5A6N
1
DAPK3_HUMAN
B:
[3-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
L
S
----
S
------
S
--
R
RGVSR
E
---
E
----
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
E--------
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
-
K
A
I
------------------------------------------------
70
Blastp_CBE
60.80
44%
-8
- C1 -
-
5AUZ
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-------
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
515
Blastp_CBE
60.73
35%
-18
- C1 -
-
2UZU
1
KAPCA_BOVIN
E:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--------
K
VVK
L
K
----
Q
------
I
--
E
-----
H
---
T
----
L
N
-
E
K
R
I
L
Q
A
V
--
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
-
R
----
I
G
----
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
-
L
L
I
-----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
-----
K
---
G
--
R
-----
T
W
-
T
L
---
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
S
K
G
---
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
A
D
--
Q
P
--
I
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-
A
T
T
D
W
I
A
I
Y
Q
R
K
---------------------------------------
206
Blastp_CBE
60.65
39%
-8
- C1 -
-
4IH8
1
?
A:
[51-341]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
----
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
300
Blastp_CBE
60.61
37%
-41
- C1 -
-
5KZ8
1
MARK2_HUMAN
A:
[34-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--------
Q
---
L
N
----
S
------
S
--
S
L----
Q
---
K
----
L
F
R
E
V
R
I
M
K
V
L
--
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
----
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
--
V
-
A
----
H
G
----
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
-----
D
A
D
M
N
I
K
I
A
D
F
G
-----------------------------------
C
G
S
P
P
Y
A
A
P
E
L
---
F
------
Q
G
K
K
---
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
----
Q
--
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
--
P
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
-
N
V
G
H
E
D
D
E
L
K
-----------------------------------------
93
Blastp_CBE
60.45
40%
12
- C1 -
-
5VJA
2
DAPK3_HUMAN
A:
[3-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
----------------------------
R
RGVSR
E
---
E
----
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
EAGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
-
K
A
-------------------------------------------------
277
Blastp_CBE
60.39
38%
-47
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[16-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
-----
T
--------
Q
---
L
N
P---
S
------
S
--
L
-----
Q
---
K
----
L
F
R
E
V
R
I
M
K
G
L
--
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
----
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
--
V
-
S
----
H
G
----
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
-
L
L
L
-----
D
A
E
A
N
I
K
I
A
D
F
G
F
S
N
----------------------------------
S
P
P
Y
A
A
P
E
L
---
F
------
Q
G
K
K
---
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
----
H
--
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
V
--
P
F
Y
--
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
-----
T
L
E
Q
I
M
K
D
K
W
I
-
N
I
G
------------------------------------------------
64
Blastp_CBE
60.22
44%
-0
- C1 -
-
6AAR
1
DAPK1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
----------------------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
213
Blastp_CBE
60.15
39%
-10
- C1 -
-
5T6A
1
?
A:
[69-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA-------
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
202
Blastp_CBE
60.03
39%
-45
- C1 -
-
3LIJ
1
?
A:
[39-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
-------------------------------
S
--
S
-----
N
---
S
K---
L
L
E
E
V
A
V
L
K
L
L
--
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
----
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
--
I
-
H
----
R
M
----
K
----
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
-
S
K
E
-
K
D
A
L
I
K
I
V
D
F
G
L
S
A
--
V
--
F
EN---
Q
---
K
--
K
-----
M
K
-
E
R
---
L
G
T
A
Y
Y
I
A
P
E
V
---
L
------
R
K
K
----
Y
-
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
-------
G
G
--
Q
T
--
D
Q
-
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
-----
S
A
Q
Q
A
L
E
H
P
W
I
----------------------------------------------------
513
Blastp_CBE
59.87
35%
-19
- C1 -
-
2UZW
1
KAPCA_BOVIN
E:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--------
K
VVK
L
K
----
Q
------
I
--
E
-----
H
---
T
----
L
N
-
E
K
R
I
L
Q
A
V
--
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
-
R
----
I
G
----
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
-
L
L
I
-----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
-----
K
---
G
--
R
-----
T
W
-
T
L
---
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
S
K
G
---
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
A
D
--
Q
P
--
I
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-
A
T
T
D
W
I
A
I
Y
Q
R
K
---------------------------------------
263
Blastp_CBE
59.87
38%
-19
- C1 -
-
4CZT
4
CIPKN_ARATH
D:
[13-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--------
K
V--
L
K
----
N
------
K
--
M
I----
A
---
Q
----
I
K
R
E
I
S
T
M
K
L
I
--
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
--
S
-
S
----
N
G
----
R
----
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
L
-----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
A
LP
Q
--
Q
-----
V
---
R
--
E
DGL--
L
H
-
T
T
---
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
N
K
G
---
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
----
D
S
--
N
L
T
S
L
Y
K
--
K
I
F
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
-
K
--------------------------------------------------
514
Blastp_CBE
59.85
35%
-17
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--------
K
VVK
L
K
----
Q
------
I
--
E
-----
H
---
T
----
L
N
-
E
K
R
I
L
Q
A
V
--
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
-
R
----
I
G
----
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
-
L
L
I
-----
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
--
V
-----
K
---
G
--
R
-----
T
W
-
T
L
---
C
G
T
P
E
Y
L
A
P
E
I
---
I
------
L
S
K
G
---
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
A
D
--
Q
P
--
I
Q
--
I
Y
E
K
I
V
S
G
K
V
R
F
-
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
V
N
D
I
K
N
H
K
W
F
-
A
T
T
D
W
I
A
I
Y
Q
R
K
---------------------------------------
181
Blastp_CBE
59.70
37%
-111
- C1 -
-
2XM8
1
CHK2_HUMAN
A:
[9-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-----------------------------------------------
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
-----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
---
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
241
Blastp_CBE
59.62
39%
-11
- C1 -
-
3T3U
5
?
A:
[28-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
214
Blastp_CBE
59.51
39%
-9
- C1 -
-
5JN2
1
?
A:
[69-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
228
Blastp_CBE
59.48
39%
-13
- C1 -
-
4WG5
1
?
A:
[28-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
38
Blastp_CBE
59.45
43%
39
- C1 -
-
6QMO
7
DAPK1_HUMAN
A:
[7-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
RQ
E
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
215
Blastp_CBE
59.35
39%
-10
- C1 -
-
5JMS
2
?
A:
[69-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
221
Blastp_CBE
59.34
39%
-12
- C1 -
-
6BFA
1
?
A:
[28-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
243
Blastp_CBE
59.30
39%
-11
- C1 -
-
3SX9
1
?
A:
[28-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
284
Blastp_CBE
59.23
37%
-113
- C1 -
-
5XZV
1
?
B:
[203-466]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
S
K
-----
R
--------
K
-------------------
M
-----
D
---
G
----
V
T
R
E
L
E
V
L
Q
K
L
--
N
-
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
----
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
--
A
-
A
----
H
G
----
A
----
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
-
I
L
I
E
---
Q
D
D
P
V
L
V
K
I
T
D
F
G
L
-----------------------------
T
F
---
C
G
T
L
A
Y
V
A
P
E
V
---
I
----------RNE
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
------
S
G
S
--
T
----
Q
D
Q
L
Y
K
Q
I
G
R
G
S
Y
H
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
-----
T
A
A
K
A
L
N
H
P
W
I
----------------------------------------------------
244
Blastp_CBE
59.23
39%
-11
- C1 -
-
3N51
3
?
A:
[28-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
338
Blastp_CBE
59.21
37%
-67
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[91-346]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
G
G
R
F
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
-----
R
--------
G
---
M
K
----
D
------
K
--
E
-----
E
--------
V
K
N
E
I
S
V
M
N
Q
L
--
D
-
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
----
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
--
I
D
E
----
S
Y
----
N
----
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
-
I
L
C
V
-
N
R
D
A
K
Q
--
I
K
I
I
D
F
G
L
A
R
--
R
--------
Y
---
K
--
P
REK--
L
K
-
V
N
---
F
G
T
P
E
F
L
A
P
E
V
---
V
------
N
Y
D
F
---
V
-
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
------
L
G
---
D
N
--
D
A
E
T
L
N
N
I
L
A
C
-
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
-----
S
A
S
E
A
L
K
H
P
W
L
----------------------------------------------------
37
Blastp_CBE
59.21
43%
36
- C1 -
-
6QN4
4
DAPK1_HUMAN
A:
[4-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
-
V
-
F
RQ
E
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
205
Blastp_CBE
59.18
39%
-14
- C1 -
-
4IHP
1
?
A:
[51-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
299
Blastp_CBE
59.15
37%
-35
- C1 -
-
5KZ8
1
MARK2_HUMAN
B:
[34-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--------
Q
---
L
N
----
S
------
S
--
S
L----
Q
---
K
----
L
F
R
E
V
R
I
M
K
V
L
--
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
----
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
--
V
-
A
----
H
G
----
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
-----
D
A
D
M
N
I
K
I
A
D
F
-------------------------------------
G
S
P
P
Y
A
A
P
E
L
---
F
------
Q
G
K
K
---
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
----
Q
--
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
--
P
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
-
N
V
G
H
E
D
D
E
L
K
-----------------------------------------
247
Blastp_CBE
59.15
39%
-10
- C1 -
-
4MXA
1
?
A:
[29-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
229
Blastp_CBE
59.14
39%
-14
- C1 -
-
4WG4
1
?
A:
[28-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
236
Blastp_CBE
59.12
39%
-13
- C1 -
-
3V5P
1
?
A:
[28-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
249
Blastp_CBE
59.08
38%
-15
- C1 -
-
4YZB
1
?
B:
[25-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
A
A
-----------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
K
-----
R
------------------
Q
------
K
--
T
-----
D
---
K
----
E
L
L
L
K
E
V
E
L
L
K
KL
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
N
K
R
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
ES---
T
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
F
D
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
L
E
H
E
W
L
-
K
T
T
------------------------------------------------
133
Blastp_CBE
59.07
38%
-81
- C1 -
-
2WNT
2
B:
[29-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
D
K
-----
S
--------
K
---
R
D
----
P
------
S
--
E
-----
E
---
I
-------
E
I
L
L
-
R
Y
G
--
Q
-
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
H
----
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
--
L
-
R
----
Q
K
----
F
----
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
-
I
L
Y
V
-
D
E
S
G
N
P
E
C
L
R
I
C
D
F
G
F
A
K
--
Q
--
L
-----
R
---
A
--
E
NGL--
L
M
-
T
P
---
C
Y
-------------------
K
R
Q
G
---
Y
-
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A-----
N
G
P
--
S
D
--
T
P
E
E
I
L
T
R
I
G
S
G
K
F
T
L
S
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
K
Q
V
L
Q
H
P
W
V
----------------------------------------------------
239
Blastp_CBE
58.96
39%
-15
- C1 -
-
3UPX
1
?
A:
[28-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
226
Blastp_CBE
58.94
39%
-10
- C1 -
-
5W80
1
?
A:
[28-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
203
Blastp_CBE
58.90
39%
-17
- C1 -
-
4IEB
1
?
A:
[51-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
---------------
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
-
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
274
Blastp_CBE
58.85
38%
-19
- C1 -
-
4CZU
3
CIPKN_ARATH
C:
[13-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--------
K
V--
L
K
----
N
------
K
--
M
I----
A
---
Q
----
I
K
R
E
I
S
T
M
K
L
I
--
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
--
S
-
S
----
N
G
----
R
----
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
L
-----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
A
LP
Q
--
Q
-----
V
---
R
--
E
DGL--
L
H
-
D
T
---
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
N
K
G
---
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
----
D
S
--
N
L
T
S
L
Y
K
--
K
I
F
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
-
K
--------------------------------------------------
437
Blastp_CBE
58.83
35%
-21
- C1 -
-
4DEB
3
AURKA_HUMAN
A:
[11-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
D
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
245
Blastp_CBE
58.78
39%
-13
- C1 -
-
3I7B
4
?
A:
[28-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
233
Blastp_CBE
58.71
39%
-10
- C1 -
-
4M84
1
?
A:
[28-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
19
PsiBlast_PDB
58.59
42%
39
- C1 -
-
6FHB
2
DAPK1_HUMAN
A:
[4-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
-
V
-
F
RQ
E
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
DFGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
90
Blastp_CBE
58.55
40%
2
- C1 -
-
5VJA
3
DAPK3_HUMAN
D:
[3-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
L
S
---------------VSR--
E
---
E
----
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
------
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
--
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
EAGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
-
K
A
-------------------------------------------------
266
Blastp_CBE
58.53
38%
-14
- C1 -
-
4CZT
3
CIPKN_ARATH
A:
[13-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--------
K
V--
L
K
----
N
------
K
--
M
I----
A
---
Q
----
I
K
R
E
I
S
T
M
K
L
I
--
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
--
S
-
S
----
N
G
----
R
----
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
L
-----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
A
LP
Q
--
Q
-----
V
---
R
--
E
DGL--
L
H
-
T
T
---
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
N
K
G
---
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
----
D
S
--
N
L
T
S
L
Y
K
--
K
I
F
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
-
K
--------------------------------------------------
207
Blastp_CBE
58.41
39%
-8
- C1 -
-
4IFG
1
?
A:
[51-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
276
Blastp_CBE
58.40
38%
-16
- C1 -
-
4CZU
3
CIPKN_ARATH
A:
[13-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--------
K
V--
L
K
----
N
------
K
--
M
I----
A
---
Q
----
I
K
R
E
I
S
T
M
K
L
I
--
K
-
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
--
S
-
S
----
N
G
----
R
----
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
L
-----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
A
LP
Q
--
Q
-----
V
---
R
--
E
DGL--
L
H
-
D
T
---
C
G
T
P
N
Y
V
A
P
E
V
---
I
------
N
N
K
G
---
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
----
D
S
--
N
L
T
S
L
Y
K
--
K
I
F
K
A
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
-
K
--------------------------------------------------
382
Blastp_CBE
58.26
35%
-28
- C1 -
-
2J4Z
4
AURKA_HUMAN
A:
[36-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
R----
R
T
-
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
----
N
--
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
449
Blastp_CBE
58.18
35%
-13
- C1 -
-
3UOD
3
AURKA_HUMAN
A:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
D
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
--------------------------------------------
174
Blastp_CBE
58.18
37%
-47
- C1 -
-
4BDB
10
CHK2_HUMAN
A:
[7-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------------------L--
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
E----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
223
Blastp_CBE
58.11
39%
-10
- C1 -
-
5W9E
1
?
A:
[28-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
184
Blastp_CBE
57.97
37%
-20
- C1 -
-
2WTI
3
CHK2_HUMAN
A:
[8-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------------------PAL
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
E----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
285
Blastp_CBE
57.89
37%
-96
- C1 -
-
5XZV
1
RAD53_YEAST
A:
[203-465]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
S
K
-----
R
--------
K
---
V
I
----
G
------
N
--
M
-----
D
---
G
----
V
T
R
E
L
E
V
L
Q
K
L
--
N
-
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
----
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
--
A
-
A
----
H
G
----
A
----
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
-
I
L
I
E
---
Q
D
D
P
V
L
V
K
I
T
D
F
G
L
A
K
-----------------------------------
L
A
Y
V
A
P
E
V
---
I
----------NE-
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
--------
S
--
T
----
Q
D
Q
L
Y
K
Q
I
G
R
G
S
-----
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
---
D
P
N
N
-------
T
A
A
K
A
L
N
H
P
W
-----------------------------------------------------
440
Blastp_CBE
57.88
35%
-13
- C1 -
-
3UP2
3
AURKA_HUMAN
A:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
D
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
--------------------------------------------
204
Blastp_CBE
57.82
39%
-10
- C1 -
-
3HX4
3
?
A:
[52-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
----------------------------------------
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
EA---
S
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
554
Blastp_CBE
57.75
35%
-20
- C1 -
-
5DR2
2
AURKA_HUMAN
A:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
R----
R
A
-
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
435
Blastp_CBE
57.71
35%
-12
- C1 -
-
4DEE
1
AURKA_HUMAN
A:
[11-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
D
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
C
Q
---------------------------------------
302
Blastp_CBE
57.68
37%
-40
- C1 -
-
5KZ7
1
MARK2_HUMAN
A:
[34-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--------
Q
---
L
N
----
S
------
S
--
S
L----
Q
---
K
----
L
F
R
E
V
R
I
M
K
V
L
--
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
----
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
--
V
-
A
----
H
G
----
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
-----
D
A
D
M
N
I
K
I
A
D
F
-------------------------------------
G
S
P
P
Y
A
A
P
E
L
---
F
------
Q
G
K
-----D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
--------
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
--
P
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
-
N
V
G
H
E
D
D
E
L
K
-----------------------------------------
301
Blastp_CBE
57.53
37%
-34
- C1 -
-
5KZ7
1
MARK2_HUMAN
B:
[34-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--------
Q
---
L
N
----
S
------
S
--
S
L----
Q
---
K
----
L
F
R
E
V
R
I
M
K
V
L
--
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
----
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
--
V
-
A
----
H
G
----
R
----
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
-----
D
A
D
M
N
I
K
I
A
D
F
-------------------------------------
G
S
P
P
Y
A
A
P
E
L
---
F
------
Q
G
K
-----D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
--------
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
--
P
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
-
N
V
G
H
E
D
D
E
L
K
-----------------------------------------
381
Blastp_CBE
57.52
35%
-19
- C1 -
-
2J4Z
2
AURKA_HUMAN
B:
[36-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
R----
R
T
-
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
----
N
--
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
C
Q
---------------------------------------
436
Blastp_CBE
57.46
35%
-18
- C1 -
-
4DED
4
AURKA_HUMAN
A:
[11-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
D
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
394
Blastp_CBE
57.28
34%
-15
- C1 -
-
5G15
1
AURKA_HUMAN
A:
[12-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
R----
R
T
-
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
-------------------------------------------
506
Blastp_CBE
57.19
34%
-23
- C1 -
-
3NRM
1
AURKA_HUMAN
A:
[13-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
R----
R
A
-
A
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
453
Blastp_CBE
57.09
35%
-12
- C1 -
-
3UO4
4
AURKA_HUMAN
A:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
D
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
--------------------------------------------
255
Blastp_CBE
56.97
38%
-18
- C1 -
-
4YSJ
1
?
B:
[25-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
A
A
-----------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
K
-----
R
---------------------------------------------
L
L
K
E
V
E
L
L
K
KL
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
N
K
R
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
ES---
T
---
K
--
K
-----
M
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
F
D
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
A
L
E
H
E
W
L
-
K
T
T
------------------------------------------------
369
Blastp_CBE
56.90
35%
-3
- C1 -
-
2WTW
1
AURKA_HUMAN
A:
[15-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
----------------
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
--------------------------------------------
432
Blastp_CBE
56.72
35%
-13
- C1 -
-
4JBQ
1
AURKA_HUMAN
A:
[11-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
-----------------------------
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
------------------------------------------
407
Blastp_CBE
56.72
35%
-20
- C1 -
-
4ZS0
1
AURKA_HUMAN
A:
[15-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
R----
R
---------
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
425
Blastp_CBE
56.36
35%
-19
- C1 -
-
2XRU
1
AURKA_HUMAN
A:
[10-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--------------------------------
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
132
Blastp_CBE
56.21
41%
-0
- C1 -
-
3HZT
9
?
A:
[6-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
-----
S
--------
S
---
V
T
----
T
------
T
--
S
-----
N
SGA
L
----
L
D
-
E
V
A
V
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
----
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
--
I
-
L
----
R
Q
----
K
----
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
R
D
A
L
I
K
I
V
D
F
G
L
S
A
--
H
FE
V
---------------------------
G
T
A
Y
Y
I
A
P
E
V
---
L
------
R
K
K
----
Y
-
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
-------
G
G
--
Q
T
--
D
Q
-
E
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
A
E
E
A
L
N
H
P
W
I
----------------------------------------------------
548
Blastp_CBE
56.06
35%
-15
- C1 -
-
5DT4
2
AURKA_HUMAN
A:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-------------
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
185
Blastp_CBE
55.93
37%
-19
- C1 -
-
2WTD
4
CHK2_HUMAN
A:
[8-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------------------PAL
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
-----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
43
Blastp_CBE
55.89
44%
9
- C1 -
-
3ZXT
1
DAPK1_HUMAN
C:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
--
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
----
S
SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
D----------------------------
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
457
Blastp_CBE
55.88
35%
-12
- C1 -
-
3K5U
1
AURKA_HUMAN
A:
[11-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
-----------------------------
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
C
Q
---------------------------------------
550
Blastp_CBE
55.79
35%
-20
- C1 -
-
5DT0
1
AURKA_HUMAN
A:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-------------
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
485
Blastp_CBE
55.57
34%
-14
- C1 -
-
4O0W
1
AURKA_HUMAN
A:
[12-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
Y
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
-------------------------
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
------------------------------------------
472
Blastp_CBE
55.53
35%
-26
- C1 -
-
5OBJ
2
AURKA_HUMAN
A:
[14-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
R------------
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
182
Blastp_CBE
55.38
37%
-15
- C1 -
-
2XBJ
1
CHK2_HUMAN
A:
[9-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------------------AL-
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
-----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
44
Blastp_CBE
55.35
44%
6
- C1 -
-
3ZXT
1
DAPK1_HUMAN
B:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
T
K
-----SRRGVS
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----
K
----------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
D---------------------------
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
---
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
591
HHSearch
55.31
33%
-59
- C1 -
-
2YWP
1
CHK1_HUMAN
A:
[5-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------
R
---
A
V
----
D
------
C
--
P
-----
E
---
N
----
I
K
K
E
I
C
I
N
K
M
L
--
N
-
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
-
P
----
D
I
----
G
----
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
-
L
L
L
D
-----
E
R
D
N
L
K
I
S
D
F
G
L
A
T
--
V
--
F
-----
R
---
Y
--
N
NRERL
L
N
-
K
M
---
C
G
T
L
P
Y
V
A
P
E
L
---
L
------
K
R
R
E
F--
H
-
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
------
D
Q
P
--
S
D
--
S
C
Q
E
Y
-
S
D
W
K
E
K
K
-
T
Y
-
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
-
N
K
P
------------------------------------------------
180
Blastp_CBE
55.20
37%
-12
- C1 -
-
2XM9
1
CHK2_HUMAN
A:
[9-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------------------PAL
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
GE---
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
183
Blastp_CBE
55.04
37%
-20
- C1 -
-
2WTJ
5
CHK2_HUMAN
A:
[7-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------------------PAL
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
E----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
42
Blastp_CBE
55.04
44%
-10
- C1 -
-
3ZXT
1
DAPK1_HUMAN
D:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---------------------------VS----
R
--
E
-----
D
--------
I
E
R
E
V
S
I
L
K
E
I
--
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
--
A
-
E
----------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
-
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
--
K
--
I
D---------------------------
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
D
--
T
K
---
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------
481
Blastp_CBE
54.85
35%
-22
- C1 -
-
3MYG
2
AURKA_HUMAN
A:
[14-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
-------------------------------
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
396
Blastp_CBE
54.62
34%
-12
- C1 -
-
4C3R
1
AURKA_HUMAN
A:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
------------------------------
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
405
Blastp_CBE
54.40
35%
-18
- C1 -
-
4ZTR
1
AURKA_HUMAN
A:
[15-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
-----------------------------------
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
398
Blastp_CBE
54.22
34%
-22
- C1 -
-
4C3P
1
AURKA_HUMAN
A:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
R----
R
T
-
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
186
Blastp_CBE
54.00
37%
-26
- C1 -
-
2WTC
1
CHK2_HUMAN
A:
[9-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------------------PAL
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
-----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
171
Blastp_CBE
54.00
37%
-16
- C1 -
-
4BDE
5
CHK2_HUMAN
A:
[7-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------------------AL-
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
-----
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
469
Blastp_CBE
53.90
37%
-36
- C1 -
-
6GR9
1
AURKC_HUMAN
A:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
L
K
E
S
H
F
I
V
A
L
K
V
L
F
K
-----
S
--------
Q
---
I
E
KE--
G
------
L
--
E
-----
H
---
Q
----
L
R
R
E
I
E
I
Q
A
H
L
--
Q
-
H
P
N
I
L
R
L
Y
N
Y
F
H
D
A
R
R
----
V
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
--
Q
-
K
----
S
D
----
K
----
L
D
E
Q
R
T
A
T
I
I
E
E
L
A
D
A
L
T
Y
C
H
D
K
K
V
I
H
R
D
I
K
P
E
N
-
L
L
L
G
F
R
G
E
-----
V
K
I
A
D
F
G
W
S
V
--
H
--
T
-----
P
---
S
--
L
-----
R
R
-
K
M
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
T
---
Y
-
D
E
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
Y
P
P
F
------
E
S
A
------
S
H
S
E
T
Y
R
R
I
L
K
V
D
V
R
F
--
P
L
--
S
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
R
L
-----
P
L
A
Q
I
L
K
H
P
W
V
-
Q
A
H
S
R
----------------------------------------------
486
Blastp_CBE
53.75
35%
-10
- C1 -
-
2C6D
2
AURKA_HUMAN
A:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
------------------------------
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
378
Blastp_CBE
53.50
34%
-12
- C1 -
-
5L8J
5
AURKA_HUMAN
A:
[15-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-----------------------------------
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
------------------------------------------
165
Blastp_CBE
53.49
37%
-12
- C1 -
-
4BDK
4
CHK2_HUMAN
A:
[9-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
Y
-
P
--
K
A
-----------
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------------------AL-
N
----
V
E
T
E
I
E
I
L
K
K
L
--
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
--
V
-
G
----
N
K
----
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
L
S
-
S
Q
E
E
-
D
C
L
I
K
I
T
D
F
G
H
S
K
--
I
--
L
GE---
T
---
S
--
L
-----
M
R
-
T
L
---
C
G
T
P
T
Y
L
A
P
E
V
---
L
VSV---
G
T
A
G
---
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
E
--
H
R
--
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
-
Q
--------------------------------------------------
546
Blastp_CBE
53.43
34%
-15
- C1 -
-
3LAU
1
AURKA_HUMAN
A:
[10-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
---------------------------------------
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
------------------------------------------
412
Blastp_CBE
53.30
35%
-20
- C1 -
-
3DAJ
1
AURKA_MOUSE
A:
[14-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
T
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
R
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
G
-
S
N
G
E
----
L
K
I
A
D
F
G
W
S
-----------------------------------
T
L
D
Y
L
P
P
E
M
---
I
-------------
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
------
E
A
H
--
T
Y
--
Q
E
----
T
Y
R
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
P
W
I
-
K
--------------------------------------------------
544
Blastp_CBE
53.04
34%
-16
- C1 -
-
4UZH
1
AURKA_HUMAN
A:
[10-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
---------------------------------------
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
------------------------------------------
397
Blastp_CBE
52.58
34%
-18
- C1 -
-
4C3P
1
AURKA_HUMAN
D:
[12-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
----------------
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
-------------------------------------------
461
Blastp_CBE
52.34
34%
-16
- C1 -
-
1OL6
1
AURKA_HUMAN
A:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
-
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA------------
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
N
F
G
W
S
V
--
H
-------------------------------
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
-
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
----------------------------------------------
408
Blastp_CBE
51.70
35%
-12
- C1 -
-
4BYJ
1
AURKA_HUMAN
A:
[15-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
---------------------------------------
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
478
Blastp_CBE
51.64
35%
-23
- C1 -
-
6C2T
2
AURKA_HUMAN
A:
[14-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
---------------------------
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
372
Blastp_CBE
51.58
34%
-12
- C1 -
-
6R4C
2
AURKA_HUMAN
A:
[15-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
-----------------------------------------
535
Blastp_CBE
51.51
35%
-22
- C1 -
-
5ORL
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
380
Blastp_CBE
51.50
34%
-14
- C1 -
-
4CEG
3
AURKA_HUMAN
A:
[15-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
-----------------------------------------
383
Blastp_CBE
51.48
34%
-13
- C1 -
-
5LXM
6
AURKA_HUMAN
A:
[13-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
A
----------------------------------------
519
Blastp_CBE
51.45
35%
-18
- C1 -
-
5OS6
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
533
Blastp_CBE
51.42
35%
-20
- C1 -
-
5ORO
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
534
Blastp_CBE
51.26
35%
-20
- C1 -
-
5ORN
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
521
Blastp_CBE
51.18
35%
-19
- C1 -
-
5OS3
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
463
Blastp_CBE
51.17
34%
-17
- C1 -
-
1OL7
1
AURKA_HUMAN
A:
[12-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
--
R
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
------------------------------------------
527
Blastp_CBE
51.04
35%
-19
- C1 -
-
5ORW
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
524
Blastp_CBE
50.98
35%
-19
- C1 -
-
5ORZ
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
517
Blastp_CBE
50.93
35%
-19
- C1 -
-
5OSF
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
530
Blastp_CBE
50.86
35%
-16
- C1 -
-
5ORS
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
373
Blastp_CBE
50.72
34%
-14
- C1 -
-
6R4B
1
AURKA_HUMAN
A:
[15-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
-----------------------------------------
419
Blastp_CBE
50.66
34%
-12
- C1 -
-
6C83
1
AURKA_HUMAN
B:
[15-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
-------------------------------------
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
---------------------------------------------
532
Blastp_CBE
50.55
35%
-22
- C1 -
-
5ORP
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
525
Blastp_CBE
50.51
35%
-20
- C1 -
-
5ORY
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
531
Blastp_CBE
50.43
35%
-18
- C1 -
-
5ORR
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
477
Blastp_CBE
50.39
35%
-17
- C1 -
-
5OSD
2
AURKA_HUMAN
A:
[9-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
426
Blastp_CBE
50.38
34%
-13
- C1 -
-
4BN1
1
AURKA_HUMAN
A:
[15-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
M
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
--
R
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
-------------------------------------------
379
Blastp_CBE
50.27
34%
-13
* C1 *
-
5G1X
1
AURKA_HUMAN
A:
[15-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
-------------------------------------------
371
Blastp_CBE
50.25
34%
-12
- C1 -
-
6R4D
2
AURKA_HUMAN
A:
[15-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
-----------------------------------------
526
Blastp_CBE
50.20
35%
-18
- C1 -
-
5ORX
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
520
Blastp_CBE
50.12
35%
-18
- C1 -
-
5OS4
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
523
Blastp_CBE
49.98
35%
-19
- C1 -
-
5OS0
2
AURKA_HUMAN
A:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
464
Blastp_CBE
49.94
34%
-18
- C1 -
-
1OL5
1
AURKA_HUMAN
A:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
--
R
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
--------------------------------------------
466
Blastp_CBE
49.91
35%
-16
- C1 -
-
5OS5
2
AURKA_HUMAN
A:
[9-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
A
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
327
Blastp_CBE
49.82
39%
-5
- C1 -
-
3NYV
1
?
A:
[28-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--------
Q
---
V
K
----
Q
------
K
--
T
-----
D
KE-
S
----
L
L
R
E
V
Q
L
L
K
Q
L
--
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
--
I
-
S
----
R
K
----
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
L
E
--
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
--
H
--
F
E----
A
---
S
--
K
-----
K
K
-
D
K
---
I
G
T
A
Y
Y
I
A
P
E
V
---
L
-------
H
G
T
---
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
A
------
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
L
T
Y
V
--
P
S
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
-
Q
T
Y
T
K
----------------------------------------------
474
Blastp_CBE
49.72
34%
-6
- C1 -
-
2WTV
5
AURKA_HUMAN
C:
[15-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
------------
P
-----
S
S
-
R
R
---
L
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
-----------------------------------------
482
Blastp_CBE
49.61
35%
-12
- C1 -
-
2X81
1
AURKA_HUMAN
A:
[14-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
---
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
---------------------------------------
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
368
Blastp_CBE
49.37
35%
-22
- C1 -
-
3E5A
1
AURKA_HUMAN
A:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
-----
P
---
S
--
S
-----
R
R
-
T
L
---
C
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
----------------------------------------------------
473
Blastp_CBE
48.96
34%
-2
- C1 -
-
2WTV
3
AURKA_HUMAN
D:
[15-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
------------
P
-----
S
S
-
R
R
---
L
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
-----------------------------------------
475
Blastp_CBE
48.74
34%
-5
- C1 -
-
2WTV
9
AURKA_HUMAN
B:
[15-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--------
Q
---
L
E
KA--
G
------
V
--
E
-----
H
---
Q
----
L
R
R
E
V
E
I
Q
S
H
L
--
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
--
Q
-
K
----
L
S
----
K
----
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
L
-----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
--
H
--
A
------------
P
-----
S
S
-
R
R
---
L
G
T
L
D
Y
L
P
P
E
M
---
I
------
E
G
R
M
---
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
N
--
T
Y
--
Q
E
----
T
Y
K
R
I
S
R
V
E
F
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
--
T
A
N
S
S
K
P
S
N
-----------------------------------------
104
Blastp_CBE
45.99
40%
-0
- C1 -
-
2J90
2
DAPK3_HUMAN
A:
[24-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
L
S
----
S
------
R
--
R
-----
G
---
V
SREE
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
----
S
----
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
EA--------------------------
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
I
A
-
Q
S
L
E
H
S
W
I
-
K
A
I
R
R
----------------------------------------------
326
Blastp_CBE
45.32
41%
-20
- C1 -
-
3R1N
1
MAPK3_HUMAN
A:
[16-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
Y
D
-----
S
--------
P
---
K
A
----
R
------
Q
--
E
--------------
V
D
H
H
W
---
Q
A
S
--
G
-
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
GKRC
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
--
Q
-
E
RG--------
A
----
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
-
L
L
Y
T
-
S
K
E
-
K
D
A
V
L
K
L
T
D
F
G
F
A
K
--
E
--
T
-----
T
------------------------------------------
P
E
K
---
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
----------------------------
Y
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
-----
T
I
T
Q
F
M
N
H
P
W
I
----------------------------------------------------
103
Blastp_CBE
44.88
40%
-3
- C1 -
-
2J90
3
DAPK3_HUMAN
B:
[27-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
----
K
E
Y
A
A
K
F
I
K
K
-----
R
--------
R
---
L
S
----
S
------
R
--
R
-----
G
---
V
SREE
I
E
R
E
V
N
I
L
R
E
I
--
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
--
A
-
E
----
K
E
---------
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
L
L
-
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
--
K
--
I
EAGNE
F
---
K
--
N
-----
I
F
-------
G
T
P
E
F
V
A
P
E
I
---
V
------
N
Y
E
P
---
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
---
E
T
--
K
Q
E
T
L
T
N
I
S
A
V
-
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
I
A
-
Q
S
L
E
H
S
W
I
-
K
A
I
R
R
R
N
--------------------------------------------
330
Blastp_CBE
44.25
41%
-16
- C1 -
-
3FHR
1
MAPK3_HUMAN
A:
[35-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
Y
D
-----
S
--------
P
---
K
A
----
R
------
Q
--
E
--------------
V
D
H
H
W
---
Q
A
S
--
G
-
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
GKRC
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
--
Q
-
E
R---
D
Q
----
A
----
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
-
L
L
Y
T
-
S
K
E
-
K
D
A
V
L
K
L
T
D
F
G
F
A
K
--
E
--
T
-------------------------------------------------
E
K
---
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-----------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
-----
T
I
T
Q
F
M
N
H
P
W
I
----------------------------------------------------
329
Blastp_CBE
43.54
41%
-10
- C1 -
-
3FXW
1
MAPK3_HUMAN
A:
[35-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
G
L
G
V
-
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
Y
D
-----
S
--------
P
---
K
A
----
R
------
Q
--
E
--------------
V
D
H
H
W
---
Q
A
S
--
G
-
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
GKRC
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
--
Q
-
E
R---
D
Q
----
A
----
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
-
L
L
Y
T
-
S
K
E
-
K
D
A
V
L
K
L
T
D
F
G
F
A
K
--
E
----------------------------------------------------
E
K
---
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-----------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
-----
T
I
T
Q
F
M
N
H
P
W
I
----------------------------------------------------