@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DUSTY_HUMAN: (2021-11-22 )
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQDCNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAHQGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDLVNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESERSPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAKALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLQGIMNRLCKSNSEQPNRGLDDST
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.....-..170.......180.......190.......200.......210.......-220....-...230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530--...---.....540.......550....--...560.......570.-......580.......590.-......600.......610...--....620.......630.......640...--....------------650----------...---....660.......670-------.-----......680---.---...----.-..690.-.....-.700....--...710....---------...720.......730------......-----..-.-740.-...------.---.---------.--------.750.......760.......770--.......780....-...790.......800---...----.-----.----..---.---.----810...-.-...-820--.-.-.-...-..830.......840.------..----....850.......860.....-------..870-....-..---...880.......890.....----..900-----.........910.......920.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEGDGVPWGSEPVSGPGPGG
G
G
M
I
R
E
L
C
R
G
F
G
R
Y
R
R
Y
L
G
R
L
R
Q
N
L
R
E
T
Q
K
F
F
R
D
IKCSHN
H
T
C
L
S
SLTGGGGAERGPAG
D
V
A
E
T
GLQAGQ
L
S
C
ISFPP
K
E
E
K
Y
L
Q
Q
I
V
D
C
L
P
C
I
L
I
LGQDC
N
V
K
C
Q
L
L
N
L
L
LG
V
Q
V
L
PTTKLGSEES
C
K
L
R
R
L
R
F
TYGTQ
T
R
V
S
L
AL-PG
Q
Y
E
L
V
H
T
L
V
AHQGNWETIPEED
L
E
VQENNE
D
A
A
H
V
L
A
E
L
E
V
T
M
H
H
A
L
L
Q
E-VD
V
V
VAP-CQGL
R
P
T
V
D
V
L
G
D
L
V
N
D
F
L
P
V
I
T
Y
A
L
H
K
D
E
L
SER
D
E
Q
E
L
Q
E
I
R
K
Y
FSFP
V
F
F
F
KVPKL
G
S
E
I
I
D
S
S
T
R
R
M
E
S
ERS
P
L
Y
R
Q
L
I
D
L
GYLSSSHWNCGAPGQD
T
K
A
Q
S
M
L
V
E
Q
S
E
K
L
R
H
L
S
T
F
S
H
Q
V
L
Q
T
R
L
V
D
A
A
K
A
L
N
L
V
H
C
H
C
L
D
I
F
I
N
Q
A
FDMQRDLQIT
P
K
R
L
E
Y
T
R
K
K
E
N
E
L
Y
E
S
L
M
N
I
A
N
R
K
Q
E
E
M
K
D
M
I
V
E
T
L
N
T
M
K
E
E
L
L
DDATN
M
E
F
K
D
V
I
VPENGEPV
G
T
R
E
I
K
C
C
I
R
Q
I
Q
E
L
I
I
S
R
L
N
Q
A
V
A
N
K
L
I
S
S
V
D
Y
L
R
E
S
F
V
G
T
L
E
R
C
L
Q
S
L
EKSQ
D
V
S
V
H
I
T
S
N
Y
L
K
Q
I
LNA
A
Y
H
V
E
V
T
F---HSG---
S
S
V
T
R
M
L
W
E
Q
I
K
Q
I
I
Q
R
ITWVS--P
P
A
I
T
L
E
W
K
R
K
V
A
Q
E
A
I
-
E
S
L
S
A
S
K
L
A
K
S
I
C
S
Q
F
R
T
RL-NSS
H
E
A
F
A
A
S
L
R
Q
L
EAGHSGRL--E
K
T
E
D
L
W
L
R
V
RKDHAP
R
L
A
R
L
S
LESC
S
L
Q
D
--
V
L
L
H------------RKP----------K
L
G
---
Q
E
LGRGQ
Y
G
V
V
Y
L
CDNW-------G-----GHF
P
C
A
L
K
S---V---VPP----D-EKH
W
N
D
-
L
A
L
E
F
-
H
Y
M
R
SLP
K
--
H
E
R
L
V
D
LHG
S
---------
V
I
D
Y
NYGG
G
S
S
I
A
V
--------
L
L
I
M
E
R
-----
L
H
-
R
-
D
-
L
Y
-
T
G
L
------K---A---------G--------L
T
L
E
T
R
L
Q
I
A
L
D
V
V
E
G
I
R
F
L
H
SQG--LVHRD
I
K
L
K
N
VLLD-KQNRAKITDLGFC
K
-----
P
E
A
----M-----M----SG---S---I----VGTPIH-M-A
P
E
-LF---T-G-K-YDN-S
V
D
V
Y
A
F
G
I
L
F
W
Y
ICS------GS----VK
L
P
E
A
F
E
R
CAS
K
D
H
L
W
N
N
V
R
R-------GAR---PERL-PV---F
D
E
E
C
W
Q
L
M
E
A
CWDGD
P
L
K
R
P
----
L
L
G
-------
I
V
Q
P
M
L
Q
G
I
M
N
R
L
CKSNSEQPNRGLDDST
228
Fugue
74.85
18%
-19
- C3 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-533]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
---
E
G
M
---
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
---
H
E
--
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
---
L
-
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
--
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
--
F
L
Q
W
------------
K
W
L
EAQPMGEDWF
L
D
F
---
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
-------
A
-----
T
G
K
L
Y
A
C
K
K
---
L
---
N
K
K
----
R
-
L
K
K
R
K
G
-
Y
Q
G
A
M
-
V
E
K
K
I
L
A
K
--
V
H
S
R
F
--------------
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
--------
C
L
V
M
T
I
-----
M
N
G
G
-
D
-
I
R
-
Y
H
I
YNVDED
N
---
P
---------
G
--------
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
--
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
D
G
N
V
R
I
S
D
L
G
L
A
V
ELK--
A
G
Q
----
T
-----
K
----
T
K
---
G
---
Y
----
A
G
T
P
G
F
-
M
-
A
P
E
-
L
L
---
L
-
G
-
E
E
Y
D
F
-
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
------
A
R
----
G
P
F
R
A
R
G
E
K
-
V
E
N
K
E
L
K
Q
R
V
L
E
-------
Q
-
A
---
V
T
Y
P
-
D
K
---
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
----
G
F
R
DGSCDGL
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
225
Fugue
65.84
18%
25
* C3 *
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
---
H
S
L
CER
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
--
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
-
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
FQ
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
--
K
W
L
E
------------
R
Q
P
VTKNTF----
R
Q
Y
---
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
-------
A
-----
T
G
K
M
Y
A
C
K
K
---
L
---
E
K
K
----
R
-
I
K
K
R
K
G
-
E
A
M
A
L
-
N
E
K
Q
I
L
E
K
--
V
N
-----
S
R
F
---------
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
--------
C
L
V
L
T
L
MNGGD
L
K
-
F
-
H
-
I
Y
-
H
M
G
------
Q
---
A
---------
G
--------
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
H
G
H
I
R
I
S
D
L
G
L
A
V
HV---
P
E
G
----
Q
-----
T
----
I
K
---
G
---
R
----
V
G
T
V
G
Y
-
M
-
A
P
E
-
V
V
---
K
-
N
E
R
-
Y
T
F
-
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
------
G
Q
----
S
P
F
Q
Q
R
K
K
K
-
I
K
R
E
E
V
E
R
L
V
K
E
-------
V
P
E
---
E
Y
S
--
E
R
---
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
----
G
C
R
GGSAREV
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
3
PsiBlast_PDB
62.91
30%
-17
- C5 -
-
3CBL
3
A:
[110-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
------------
E
D
L
----------
V
L
G
---
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-------
A
-----
D
N
T
L
V
A
V
K
S
CRE
T
---
L
P
P
----
D
-
L
K
--
A
K
-
F
L
Q
E
A
-
R
I
L
K
Q
Y
-
S
--
H
P
N
I
V
R
L
I
G
V
---------
C
T
Q
K
Q
-------
P
I
--------
Y
I
V
M
E
L
-----
V
Q
-
G
G
D
-
F
L
-
T
F
L
------
R
TEG
A
---------
R
--------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-----
E
E
A
DGVY
A
-----
A
----
S
G
---
G
---
L
----
R
Q
V
P
V
K
W
T
-
A
P
E
A
L
N
---
Y
-
G
-
R
-
Y
S
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L-----
G
A
----
S
P
Y
P
N
-----
L
S
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
LPC
P
E
L
C
-
P
------
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------
2
PsiBlast_PDB
62.86
30%
-19
- C5 -
-
3BKB
7
A:
[110-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
------------
E
D
L
----------
V
L
G
---
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-------
A
-----
D
N
T
L
V
A
V
K
S
CRE
T
---
L
P
P
----
D
-
L
K
--
A
K
-
F
L
Q
E
A
-
R
I
L
K
Q
Y
-
S
--
H
P
N
I
V
R
L
I
G
V
---------
C
T
Q
K
Q
-------
P
I
--------
Y
I
V
M
E
L
-----
V
Q
-
G
G
D
-
F
L
-
T
F
L
------
R
TEG
A
---------
R
--------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-----
E
E
A
DGVY
A
-----
A
----
S
G
---
G
---
L
----
R
Q
V
P
V
K
W
T
-
A
P
E
A
L
N
---
Y
-
G
-
R
-
Y
S
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L-----
G
A
----
S
P
Y
P
N
-----
L
S
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
LPC
P
E
L
C
-
P
------
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------
5
PsiBlast_PDB
62.72
30%
-18
- C5 -
-
6JMF
1
A:
[108-373]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
------------
E
D
L
----------
V
L
G
---
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-------
A
-----
D
N
T
L
V
A
V
K
S
CRE
T
---
L
P
P
----
D
-
L
K
--
A
K
-
F
L
Q
E
A
-
R
I
L
K
Q
Y
-
S
--
H
P
N
I
V
R
L
I
G
V
---------
C
T
Q
K
Q
-------
P
I
--------
Y
I
V
M
E
L
-----
V
Q
-
G
G
D
-
F
L
-
T
F
L
------
R
TEG
A
---------
R
--------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-----
E
E
A
DGVY
A
-----
A
----
S
G
---
G
---
L
----
R
Q
V
P
V
K
W
T
-
A
P
E
A
L
N
---
Y
-
G
-
R
-
Y
S
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L-----
G
A
----
S
P
Y
P
N
-----
L
S
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
LPC
P
E
L
C
-
P
------
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------
224
Fugue
62.45
24%
-5
- C5 -
-
3CD3
3
A:
[1-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
-
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
-
V
R
E
S
Q
E
Y
V
L
S
V
P
R
H
F
I
I
N
L
Y
R
L
--
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
K
D
KW
V
L
N
H
------------
E
D
L
----------
V
L
G
---
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-------
A
-----
D
N
T
L
V
A
V
K
S
---
C
---
R
P
D
----
L
-
K
A
K
F
L
----
Q
E
A
-
R
I
L
K
Q
Y
S
---
H
P
N
I
V
R
L
I
G
V
---------
C
---
T
Q
K
Q
P
I
Y
I
V
M
--------
E
L
V
Q
G
G
-----
D
F
-
L
-
T
-
F
L
-
R
T
E
------
G
---
A
---------
R
--------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-
E
K
N
V
L
K
I
S
D
F
G
M
S
R
EEA--
D
G
V
----
A
-----
A
----
S
G
---
G
---
L
----
R
Q
V
P
V
K
W
T
-
A
P
E
-
A
L
---
N
Y
G
-
R
-
Y
S
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L-----
G
A
----
S
P
Y
P
N
L
-----
S
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
---
L
P
C
P
-
E
L
---
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
----------------
222
Fugue
60.61
18%
14
- C3 -
-
4BTF
2
MLKL_MOUSE
A:
[7-460]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
L
G
Q
I
I
K
L
G
Q
L
I
Y
E
Q
C
EKM
K
Y
C
---
R
K
Q
C
Q
R
L
G
N
R
V
H
G
L
L
Q
P
L
Q
R
L
Q
AQ
G
K
K
N
L
P
D
D
I
T
A
A
L
G
R
F
D
-
E
V
L
K
E
A
N
Q
Q
I
E
K
F
I
L
F
H
E
V
N
-
E
K
L
R
D
V
W
E
E
L
L
L
L
L
Q
V
P
A
S
W
Q
Q
--
E
D
R
Q
D
A
E
E
D
G
N
E
N
M
K
V
I
L
M
Q
L
Q
I
S
V
E
E
I
N
K
--
T
L
K
Q
CSIPQDLQIKEI
P
K
E
----------
H
L
G
PPW
T
K
L
K
T
S
K
M
S
T
I
Y
R
G
E
Y
H
-------
R
-------
S
P
V
T
I
K
V
---
F
---
N
N
P
QAES
V
-
G
I
V
R
F
T
-
F
N
D
E
I
-
K
T
M
K
K
F
-
D
--
S
P
N
I
L
R
I
F
G
I
---------
C
I
D
---
Q
T
V
K
P
P
E
F
--------
S
I
V
M
E
Y
-----
C
E
-
L
G
T
-
L
R
-
E
L
L
------
D
---
R
EK-------
D
--------
L
T
M
S
V
R
S
L
L
V
L
R
A
A
R
G
L
Y
R
L
H
H
S
E
--
T
L
H
R
N
I
S
S
S
S
F
L
V
A
-
G
G
Y
Q
V
K
L
A
G
F
E
L
S
K
-----
T
Q
N
----
S
-----
I
----
S
R
---
T
--------
A
S
S
T
I
Y
-
V
-
S
P
E
-
R
L
KNP
F
-
C
-
L
-
Y
D
I
-
K
A
E
I
Y
S
F
G
I
V
L
W
E
I
A
T
------
G
K
----
I
----
P
F
E
G
C
D
S
K
K
I
R
E
L
V
A
E
D
-------
K
K
Q
---
E
P
V
G
-
Q
D
---
C
P
E
L
L
R
E
I
I
N
E
C
R
A
H
E
P
S
Q
R
P
----
S
V
D
-------
G
I
L
E
R
L
S
A
---------------------
1
PsiBlast_PDB
60.18
30%
-4
- C5 -
-
3CD3
3
A:
[110-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
------------
E
D
L
----------
V
L
G
---
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-------
A
-----
D
N
T
L
V
A
V
K
S
CR-------
P
----
D
-
L
K
--
A
K
-
F
L
Q
E
A
-
R
I
L
K
Q
Y
-
S
--
H
P
N
I
V
R
L
I
G
V
---------
C
T
Q
K
Q
-------
P
I
--------
Y
I
V
M
E
L
-----
V
Q
-
G
G
D
-
F
L
-
T
F
L
------
R
TEG
A
---------
R
--------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-----
E
E
A
DGVY
A
-----
A
----
S
G
---
G
---
L
----
R
Q
V
P
V
K
W
T
-
A
P
E
A
L
N
---
Y
-
G
-
R
-
Y
S
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L-----
G
A
----
S
P
Y
P
N
-----
L
S
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
LPC
P
E
L
C
-
P
------
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------
7
PsiBlast_PDB
59.97
27%
-45
- C5 -
-
3PPZ
1
CTR1_ARATH
A:
[41-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
---
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
-
W
-------
H
-----
G
S
-
D
V
A
V
K
I
---
L
---
M
E
-------
A
E
R
V
N
E
-
F
L
R
E
V
-
A
I
M
K
R
L
-
R
--
H
P
N
I
V
L
F
M
G
A
---------
V
T
--
Q
P
P
N
L
S
I
V
T
E
--------
Y
L
S
R
G
S
-----
L
Y
-
R
-
L
-
L
H
K
S
G
A
------
R
---
E
---------
Q
--------
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
PP
I
V
H
R
D
L
K
S
P
N
L
L
V
D
-
K
K
Y
T
V
K
V
C
D
F
G
L
S
R
-----
L
K
A
STF-
L
-----
S
----
S
K
---
S
---
A
----
A
G
T
P
E
W
-
M
-
A
P
E
-
V
L
---
R
-
D
-
E
-
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
------------------------
A
T
L
Q
Q
P
W
G
N
L
N
P
AQVVAAV
G
F
K
---
C
K
R
L
-
E
I
PRN
L
N
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
----
S
F
A
-------
T
I
M
D
L
L
R
P
----
L
I
K
--------------
211
HHSearch
59.72
28%
-34
- C5 -
-
3BKB
7
A:
[113-375]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
------------
E
D
L
----------
V
L
G
---
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-------
A
-----
D
N
T
L
V
A
V
K
S
---
C
---
R
E
T
----
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
-
R
I
L
K
Q
Y
-
S
--
H
P
N
I
V
R
L
I
G
V
---------
C
T
Q
K
-------
Q
P
I
--------
Y
I
V
M
E
L
-----
V
Q
G
G
-
D
-
F
L
-
T
F
L
------
R
---
T
EGA------
R
--------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-----
E
E
A
----
D
GVYAA
S
----
G
G
---
L
---
R
----
Q
V
P
V
K
W
-
T
-
A
P
E
-
A
L
---
N
-
Y
G
R
-
Y
S
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L-----
G
A
----
S
P
Y
P
N
L
S
N
-----
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
---
L
P
C
P
-
E
L
---
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------
4
PsiBlast_PDB
59.70
30%
-19
- C5 -
-
4E93
1
A:
[110-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
------------
E
D
L
----------
V
L
G
---
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-------
A
-----
D
N
T
L
V
A
V
K
S
CRE
T
---
L
P
P
----
D
-
L
K
--
A
K
-
F
L
Q
E
A
-
R
I
L
K
Q
Y
-
S
--
H
P
N
I
V
R
L
I
G
V
---------
C
T
Q
K
Q
-------
P
I
--------
Y
I
V
M
E
L
-----
V
Q
-
G
G
D
-
F
L
-
T
F
L
------
R
TEG
A
---------
R
--------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-----
E
---------------------------------
V
P
V
K
W
T
-
A
P
E
A
L
N
---
Y
-
G
-
R
-
Y
S
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L-----
G
A
----
S
P
Y
P
N
-----
L
S
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
LPC
P
E
L
C
-
P
------
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------
10
PsiBlast_PDB
59.59
29%
-52
- C5 -
-
3SXS
1
A:
[12-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
E
L
G
S
G
Q
F
G
V
V
K
L
-
G
K
W
-------
K
-----
G
Q
Y
D
V
A
V
K
----
M
---
I
K
E
----
G
-
S
M
S
E
D
E
-
F
F
Q
E
A
-
Q
T
M
M
K
L
-
S
--
H
P
K
L
V
K
F
Y
G
V
---------
C
-------
S
K
E
Y
P
I
--------
Y
I
V
T
E
Y
-----
I
S
-
N
-
G
C
L
L
-
N
Y
L
------
R
---
S
HGK------
G
--------
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
--
F
I
H
R
D
L
A
A
R
N
C
L
V
D
-
R
D
L
C
V
K
V
S
D
F
G
M
T
R
YVL--
D
D
Q
----
Y
-----
V
----
S
S
---
V
---
G
----
T
K
F
P
V
K
-
W
S
A
P
E
-
V
F
H--
Y
-
F
-
K
-
Y
S
S
-
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
------
L
G
-----
K
M
P
Y
D
L
---
Y
T
N
S
E
V
V
L
K
V
S
Q
-------
G
H
R
---
L
Y
R
P
-
H
L
---
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
TFQQ
L
L
S
-------
S
I
E
P
L
------------------------
212
HHSearch
59.48
28%
-32
- C5 -
-
3CBL
3
A:
[113-375]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
------------
E
D
L
----------
V
L
G
---
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-------
A
-----
D
N
T
L
V
A
V
K
S
---
C
---
R
E
T
----
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
-
R
I
L
K
Q
Y
-
S
--
H
P
N
I
V
R
L
I
G
V
---------
C
T
Q
K
-------
Q
P
I
--------
Y
I
V
M
E
L
-----
V
Q
G
G
-
D
-
F
L
-
T
F
L
------
R
---
T
EGA------
R
--------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-----
E
E
A
----
D
GVYAA
S
----
G
G
---
L
---
R
----
Q
V
P
V
K
W
-
T
-
A
P
E
-
A
L
---
N
-
Y
G
R
-
Y
S
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L-----
G
A
----
S
P
Y
P
N
L
S
-----
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
---
L
P
C
P
-
E
L
---
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------
210
HHSearch
59.37
28%
-33
- C5 -
-
6JMF
1
A:
[111-373]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
------------
E
D
L
----------
V
L
G
---
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-------
A
-----
D
N
T
L
V
A
V
K
S
---
C
---
R
E
T
----
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
-
R
I
L
K
Q
Y
-
S
--
H
P
N
I
V
R
L
I
G
V
---------
C
T
Q
K
-------
Q
P
I
--------
Y
I
V
M
E
L
-----
V
Q
G
G
-
D
-
F
L
-
T
F
L
------
R
---
T
EGA------
R
--------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
--
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-----
E
E
A
----
D
GVYAA
S
----
G
G
---
L
---
R
----
Q
V
P
V
K
W
-
T
-
A
P
E
-
A
L
---
N
-
Y
G
R
-
Y
S
S
-
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L-----
G
A
----
S
P
Y
P
N
L
S
N
-----
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
---
L
P
C
P
-
E
L
---
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
----
S
F
S
-------
T
I
Y
Q
E
L
Q
S
I
R
K
R
-----------------
9
PsiBlast_PDB
58.87
29%
-51
- C5 -
-
3SXR
1
BMX_HUMAN
A:
[12-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
---
K
E
L
G
S
----
V
V
K
L
-
G
K
W
-------
K
-----
G
Q
Y
D
V
A
V
K
----
M
---
I
K
E
----
G
-
S
M
S
E
D
E
-
F
F
Q
E
A
-
Q
T
M
M
K
L
-
S
--
H
P
K
L
V
K
F
Y
G
V
---------
C
-------
S
K
E
Y
P
I
--------
Y
I
V
T
E
Y
-----
I
S
-
N
-
G
C
L
L
-
N
Y
L
------
R
---
S
HGK------
G
--------
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
--
F
I
H
R
D
L
A
A
R
N
C
L
V
D
-
R
D
L
C
V
K
V
S
D
F
G
M
T
R
YVL--
D
D
Q
----
Y
-----
V
----
S
S
---
V
---
G
----
T
K
F
P
V
K
-
W
S
A
P
E
-
V
F
H--
Y
-
F
-
K
-
Y
S
S
-
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
------
L
G
-----
K
M
P
Y
D
L
---
Y
T
N
S
E
V
V
L
K
V
S
Q
-------
G
H
R
---
L
Y
R
P
-
H
L
---
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
TFQQ
L
L
S
-------
S
I
E
P
L
------------------------
214
HHSearch
58.73
27%
-5
- C5 -
-
5A46
2
B:
[38-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
------------
D
R
L
----------
V
L
G
---
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
-------
G
LDKPN
R
V
T
K
V
A
V
K
M
---
L
---
K
S
D
----
A
T
E
K
D
L
S
D
-
L
I
S
E
M
-
E
M
M
K
M
I
G
K
--
H
K
N
I
I
N
L
L
G
A
---------
C
T
Q
D
-------
G
P
L
--------
Y
V
I
V
E
Y
-----
A
S
-
K
G
N
-
L
R
-
E
Y
L
------
Q
---
A
RRPPHNPEE
Q
--------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
I
H
----
H
IDYYK
K
----
T
T
---
N
---
G
----
R
L
P
V
K
W
-
M
-
A
P
E
-
A
L
---
F
-
D
R
I
-
Y
T
H
-
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L-----
G
G
----
S
P
Y
P
G
V
-----
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
---
M
D
K
P
-
S
N
---
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
----
T
F
K
-------
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
--------------
234
Fugue
58.27
11%
-13
- C2 -
-
2J69
-
BDLP_NOSP7
A:
[4-695]
--------------------
Q
V
A
T
D
R
F
I
Q
D
L
E
R
V
A
Q
V
R
S
E
M
S
V
C
L
N
K
L
A
E
T
I
N
K
A
E
-------------------------
L
A
G
D
S
S
S
G
K
L
S
L
E
R
D
I
E
D
I
T
I
A
S
K
N
L
Q
Q
G
V
F
R
L
L
V
L
G
D
M
K
R
G
K
S
T
F
L
N
A
L
I
G
E
N
L
L
P
S
D
V
N
P
C
T
A
V
L
----
T
V
L
R
Y
G
P
E
K
K
V
T
I
H
F
N
D
G
K
S
P
Q
Q
L
D
F
Q
N
F
K
Y
K
Y
T
I
D
P
A
E
A
K
K
L
E
Q
E
K
K
Q
A
F
P
D
V
D
Y
A
V
V
E
Y
P
L
T
L
L
Q
K
G
I
E
I
V
D
S
P
G
L
N
D
T
E
A
R
N
E
L
S
L
G
Y
V
N
N
C
H
A
I
L
F
V
M
R
A
S
Q
P
C
T
L
G
E
R
R
Y
L
E
N
Y
I
K
G
R
G
L
T
V
F
F
L
V
N
---
A
W
D
Q
V
R
E
S
L
I
D
P
D
D
V
E
E
L
Q
A
S
E
N
R
L
R
Q
V
F
N
A
N
L
A
E
Y
C
T
V
E
G
Q
N
I
Y
D
E
R
V
F
E
L
S
---------
S
I
Q
A
L
R
R
R
L
K
N
P
Q
A
D
L
D
G
T
G
F
P
K
F
M
D
S
L
N
T
F
L
T
R
E
----
R
A
I
A
E
L
R
Q
V
R
T
L
A
R
L
A
C
N
H
T
R
E
A
V
A
R
R
I
P
L
L
E
Q
------------------------------------------------------
D
V
N
E
L
K
K
R
I
D
S
V
E
P
E
F
N
K
L
T
G
I
R
D
E
F
Q
K
E
I
I
N
T
R
D
T
Q
A
R
T
I
S
E
S
F
R
S
Y
V
L
--------------------------
N
L
G
N
T
F
E
N
D
F
L
R
Y
Q
--
P
E
L
N
L
F
D
F
L
S
S
G
K
R
E
A
F
-
N
A
A
L
Q
K
A
F
E
Q
Y
I
T
D
K
S
A
A
W
T
-
L
T
A
E
K
D
I
N
A
A
F
K
E
L
S
R
S
A
S
Q
Y
G
--
A
S
Y
N
Q
I
T
D
Q
I
T
E
K
L
T
G
K
-------------------------------------------------------------------------------------------------
D
V
----
E
-
E
D
N
S
P
G
-
W
A
K
W
A
-
M
G
L
L
S
A
G
F
--
D
W
K
N
I
L
L
N
Y
F
---------
T
V
I
G
I
G
G
I
I
T
A
V
T
G
--------
I
L
L
G
P
I
-----
G
F
-
A
-
L
-
L
G
-
L
G
V
------
G
---
F
---------
L
--------
Q
A
D
Q
A
R
R
E
L
V
K
T
A
K
K
E
L
V
K
H
L
P
Q
V
--
A
H
E
Q
S
Q
V
V
Y
N
A
V
K
E
-
C
F
D
S
Y
E
R
E
V
S
K
R
I
N
-----
D
D
I
----
V
-----
S
----
R
K
---
S
---
E
----
L
D
N
L
V
K
-
Q
-
K
Q
T
-------------------------------------------------------------
R
E
I
N
R
-------
E
S
E
---
F
N
R
L
-
K
N
---
L
Q
E
D
V
I
A
Q
L
Q
K
------
I
E
A
A
----
Y
S
N
-------
L
L
A
Y
Y
S
H
H
---------------------
203
HHSearch
57.40
26%
-4
- C5 -
-
2PSQ
-
FGFR2_HUMAN
A:
[80-367]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------------
D
K
L
----------
T
L
G
---
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
GIDKDKP
K
-----
E
A
V
T
V
A
V
K
M
---
L
---
K
D
D
----
A
T
E
K
D
L
S
D
-
L
V
S
E
M
-
E
M
M
K
M
I
G
K
--
H
K
N
I
I
N
L
L
G
A
---------
C
T
Q
D
-------
G
P
L
--------
Y
V
I
V
E
Y
-----
A
S
-
K
G
N
-
L
R
-
E
Y
L
------
R
---
A
RRPPPEE--
Q
--------
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
I
N
----
N
IDYYK
K
----
T
T
---
N
---
G
----
R
L
P
V
K
W
-
M
-
A
P
E
-
A
L
---
F
-
D
-
R
V
Y
T
H
-
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L-----
G
G
----
S
P
Y
P
G
I
P
-----
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
---
M
D
K
P
-
A
N
---
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
----
T
F
K
-------
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
---------------
11
PsiBlast_PDB
56.79
27%
-5
- C5 -
-
6GQK
1
?
A:
[45-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
---
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
-------
G
LIKSD
A
A
M
T
V
A
V
K
M
---
L
---
K
P
S
----
A
-
H
S
T
E
R
E
A
L
M
S
E
L
-
K
V
L
S
Y
L
G
N
--
H
E
N
I
V
N
L
L
G
A
---------
C
T
H
----
G
G
P
T
L
V
I
TEYCCYGD
L
L
N
F
L
R
-----
R
K
-
R
-
D
-
E
F
-
V
P
Y
------
K
---
V
---------
A
PEDLYKDF
L
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
--
C
I
H
R
D
L
A
A
R
N
I
L
L
T
-
H
G
N
I
T
K
I
C
D
F
G
L
A
R
-----
D
I
K
----
N
-----
D
----
S
N
---
Y
---
V
DKGN
A
R
L
P
V
K
W
M
-
A
P
E
S
I
F
---
N
-
S
-
V
-
Y
T
F
-
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L-----
G
S
----
S
P
Y
P
----
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
-------
G
F
R
MSS
P
E
Y
A
-
P
A
------
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
----
T
F
----------
K
Q
I
V
Q
D
I
E
K
Q
I
S
E
S
-------------
14
PsiBlast_PDB
56.78
28%
-18
- C5 -
-
6GQJ
1
?
A:
[45-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
---
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
-------
G
LIKSD
A
A
M
T
V
A
V
K
M
---
L
---
K
P
S
----
A
-
H
S
T
E
R
E
A
L
M
S
E
L
-
K
V
L
S
Y
L
G
N
--
H
E
N
I
V
N
L
L
G
A
---------
C
T
H
----
G
G
P
T
L
V
I
TEYCCYGD
L
L
N
F
L
R
-----
R
K
-
R
-
D
-
E
F
-
V
P
Y
------
K
--------------KDF-----
L
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
--
C
I
H
R
D
L
A
A
R
N
I
L
L
T
-
H
G
N
I
T
K
I
C
D
F
G
L
A
R
-----
D
I
K
----
N
-----
D
----
S
N
---
Y
---
V
DKGN
A
R
L
P
V
K
W
M
-
A
P
E
S
I
F
---
N
-
S
-
V
-
Y
T
F
-
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L-----
G
S
----
S
P
Y
P
----
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
-------
G
F
R
MSS
P
E
Y
A
-
P
A
------
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
----
T
F
K
Q------
I
V
Q
D
I
E
K
Q
I
--------------------
194
Blastp_CBE
44.88
31%
-63
- C5 -
-
3ZH8
4
KPCI_HUMAN
A:
[1-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
G
L
Q
D
--
F
D
L
L
------------
R
V
-------------------
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
-------
K
-----
T
D
R
I
Y
A
M
K
V
---
V
KKE
L
V
N
----
D
-
D
E
D
I
D
W
-
V
Q
T
E
K
-
H
V
F
E
Q
A
S
N
--
H
P
F
L
V
G
L
H
S
C
FQTESRLFF
V
I
E
Y
V
N
G
G
D
----
L
--------
M
F
H
M
Q
R
-----
Q
R
-
K
--------------------------------------
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
------
E
G
----
L
-----
R
----
P
G
DTT
S
---
F
----
C
G
T
P
N
Y
-
I
-
A
P
E
-
I
L
---
R
-
G
-
E
D
Y
G
F
-
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
------
G
------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
44.61
31%
-63
- C5 -
-
3ZH8
5
KPCI_HUMAN
B:
[1-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
G
L
Q
D
--
F
D
L
L
------------
R
V
-------------------
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
-------
K
-----
T
D
R
I
Y
A
M
K
V
---
V
KKE
L
V
N
----
D
-
D
E
D
I
D
W
-
V
Q
T
E
K
-
H
V
F
E
Q
A
S
N
--
H
P
F
L
V
G
L
H
S
C
FQTESRLFF
V
I
E
Y
V
N
G
G
D
----
L
--------
M
F
H
M
Q
R
-----
Q
R
-
K
--------------------------------------
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
------
E
G
----
L
-----
R
----
P
G
DTT
S
---
F
----
C
G
T
P
N
Y
-
I
-
A
P
E
-
I
L
---
R
-
G
-
E
D
Y
G
F
-
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
------
G
------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
42.77
33%
-94
- C5 -
-
3VID
1
A:
[182-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
L
Y
----------
K
---
D
---------
F
--------
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
--
C
I
H
R
D
L
A
A
R
N
I
L
L
S
-
E
K
N
V
V
K
I
C
D
-----YKD--
P
D
Y
----
V
-----
R
----
K
G
---
D
---
A
----
R
L
P
L
K
W
-
M
-
A
P
E
T
I
F
---
D
-
R
-
V
-
Y
T
I
-
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
LGASPY
P
G
----
V
K
I
D
E
E
F
C
R
---------
R
L
K
E
-------
G
T
R
---
M
R
A
P
-
D
Y
---
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
-------------------------------------------
144
Blastp_CBE
40.55
33%
-41
- C5 -
-
5GRN
1
A:
[172-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------
L
T
L
L
D
L
L
S
F
T
Y
Q
V
A
R
G
M
E
F
L
A
S
K
N
--
C
V
H
R
D
L
A
A
R
N
V
L
L
A
-
Q
G
K
I
V
K
I
C
D
F
G
L
A
R
DIMHD
S
N
Y
----
V
-----
S
----
K
G
---
S
---
T
----
F
L
P
V
K
W
-
M
-
A
P
E
S
I
F
---
D
-
N
-
L
-
Y
T
T
-
L
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L-----
G
G
----
T
P
Y
P
G
M
M
V
D
S
T
----
F
Y
N
K
I
K
S
-------
G
Y
R
---
M
A
K
P
-
D
H
---
A
T
S
E
V
Y
E
I
M
V
K
C
W
N
S
E
P
E
K
R
P
SFYH
L
S
E
-------
I
V
E
N
L
L
P
G
---------------------
185
Blastp_CBE
39.24
32%
-74
- C5 -
-
3HNG
1
A:
[193-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
---------
P
--------
I
T
M
E
D
L
I
S
Y
S
F
Q
V
A
R
G
M
E
F
L
S
S
R
K
--
C
I
H
R
D
L
A
A
R
N
I
L
L
S
-
E
N
N
V
V
K
I
C
D
F
G
L
A
R
DIYKN
P
D
Y
----
V
-----
R
----
K
--------
T
----
R
L
P
L
K
W
-
M
-
A
P
E
S
I
F
---
D
-
K
-
I
-
Y
S
T
-
K
S
D
V
W
S
Y
G
V
L
L
W
E
I
F
S
LG----
G
S
PYPG
V
Q
M
D
E
D
F
--
C
S
-------
R
L
R
E
-------
G
M
R
---
M
R
A
P
-
E
Y
---
S
T
P
E
I
Y
Q
I
M
L
D
C
W
H
R
D
P
K
E
R
P
-------------------------------------------
133
Blastp_CBE
39.08
31%
-19
- C5 -
-
6MOM
2
?
B:
[32-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---
N
K
M
G
E
G
G
F
G
V
V
Y
--
K
G
Y
-------
V
-----
N
N
T
T
V
A
V
K
K
---
L
---
A
A
--------
I
T
T
E
E
-
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
CQ
H
E
N
L
V
E
L
L
G
-------------
F
S
S
D
G
D
D
L
C
L
V
--------
Y
V
Y
M
P
N
GSL--
L
D
-
R
-
L
-
S
C
-
L
D
G
------
T
---
P
---------
P
--------
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
--
H
I
H
R
D
I
K
S
A
N
I
L
L
D
-
E
A
F
T
A
K
I
S
D
F
G
L
A
R
-----
A
S
E
----
K
----------
A
Q
VM-
R
---
I
----
V
G
T
T
A
Y
-
M
-
A
P
E
-
A
L
---
R
-
G
-
E
-
I
T
P
-
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
------
G
------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
38.10
31%
-28
- C5 -
-
6MOM
2
?
D:
[32-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---
N
K
M
G
E
G
G
F
G
V
V
Y
--
K
G
Y
-------
V
-----
N
N
T
T
V
A
V
K
K
---
L
---
A
A
M
----
V
-
D
I
T
T
E
E
-
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
CQ
H
E
N
L
V
E
L
L
G
-------------
F
S
S
D
G
D
D
L
C
L
V
--------
Y
V
Y
M
P
N
GSL--
L
D
-
R
-
L
-
S
C
-
L
D
G
------
T
---
P
---------
P
--------
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
--
H
I
H
R
D
I
K
S
A
N
I
L
L
D
-
E
A
F
T
A
K
I
S
D
F
G
L
A
R
-----
A
S
E
----
K
-----
F
----
A
Q
VM-
R
---
I
----
V
G
T
T
A
Y
-
M
-
A
P
E
-
A
L
---
R
-
G
-
E
-
I
T
P
-
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
------
G
------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
37.51
31%
-14
- C5 -
-
2OIC
1
IRAK4_HUMAN
A:
[30-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---
N
K
M
G
E
G
G
F
G
V
V
Y
--
K
G
Y
-------
V
-----
N
N
T
T
V
A
V
K
K
-----------------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
CQ
H
E
N
L
V
E
L
L
G
-------------
F
S
S
D
G
D
D
L
C
L
V
--------
Y
V
Y
M
P
N
GSL--
L
D
-
R
-
L
-
S
C
-
L
D
G
------
T
---
P
---------
P
--------
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
--
H
I
H
R
D
I
K
S
A
N
I
L
L
D
-
E
A
F
T
A
K
I
S
D
F
G
L
A
R
-----
A
S
----------------
A
Q
VM-
R
---
I
----
V
G
T
T
A
Y
-
M
-
A
P
E
-
A
L
---
R
-
G
-
E
-
I
T
P
-
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
------
G
------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
37.35
31%
-25
- C5 -
-
2OID
1
IRAK4_HUMAN
A:
[29-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---
N
K
M
G
E
G
G
F
G
V
V
Y
--
K
G
Y
-------
V
-----
N
N
T
T
V
A
V
K
K
------------------------------
E
I
K
V
M
A
K
CQ
H
E
N
L
V
E
L
L
G
-------------
F
S
------
C
L
V
--------
Y
V
Y
M
P
N
GSL--
L
D
-
R
-
L
-
S
C
-
L
D
G
------
T
---
P
---------
P
--------
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
--
H
I
H
R
D
I
K
S
A
N
I
L
L
D
-
E
A
F
T
A
K
I
S
D
F
G
L
A
R
-----
A
S
E
----
K
----------
A
Q
VM-
R
---
I
----
V
G
T
T
A
Y
-
M
-
A
P
E
-
A
L
---
R
-
G
-
E
-
I
T
P
-
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
------
G
------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
36.31
31%
-13
- C5 -
-
2OIC
1
IRAK4_HUMAN
B:
[30-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---
N
K
M
G
E
G
--
G
V
V
Y
--
K
G
Y
-------
V
-----
N
N
T
T
V
A
V
K
K
---
L
-------------------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
CQ
H
E
N
L
V
E
L
L
G
-------------
F
S
S
D
G
D
D
L
C
L
V
--------
Y
V
Y
M
P
N
GSL--
L
D
-
R
-
L
-
S
C
-
L
D
G
------
T
---
P
---------
P
--------
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
H
--
H
I
H
R
D
I
K
S
A
N
I
L
L
D
-
E
A
F
T
A
K
I
S
D
F
G
L
A
R
-----
A
S
----------------
A
Q
VM-
R
---
I
----
V
G
T
T
A
Y
-
M
-
A
P
E
-
A
L
---
R
-
G
-
E
-
I
T
P
-
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
------
G
------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
36.29
45%
-140
- C5 -
-
4RA5
2
KPCT_HUMAN
A:
[112-202]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
------
E
N
----
M
-----
L
GDAK
T
N
---
E
---
F
----
C
G
T
P
D
Y
-
I
-
A
P
E
-
I
L
---
L
-
G
Q
K
-
Y
N
H
-
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
------
G
------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
36.14
45%
-139
- C5 -
-
4RA5
1
B:
[112-217]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
------
E
N
----
M
-----
L
GDAK
T
N
---
E
---
F
----
C
G
T
P
D
Y
-
I
-
A
P
E
-
I
L
---
L
-
G
Q
K
-
Y
N
H
-
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
------
G
------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
35.76
45%
-138
- C5 -
-
4Q9Z
1
B:
[112-224]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
------
E
N
----
M
-----
L
GDAK
T
N
---
E
---
F
----
C
G
T
P
D
Y
-
I
-
A
P
E
-
I
L
---
L
-
G
Q
K
-
Y
N
H
-
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
------
G
------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
35.48
45%
-138
- C5 -
-
4Q9Z
1
KPCT_HUMAN
A:
[112-202]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
------
E
N
----
M
-----
L
GDAK
T
N
---
E
---
F
----
C
G
T
P
D
Y
-
I
-
A
P
E
-
I
L
---
L
-
G
Q
K
-
Y
N
H
-
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
------
G
------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
35.35
45%
-132
- C5 -
-
5F9E
1
KPCT_HUMAN
A:
[126-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
------
E
N
----
M
-----
L
GDAK
T
N
---
E
---
F
----
C
G
T
P
D
Y
-
I
-
A
P
E
-
I
L
---
L
-
G
Q
K
-
Y
N
H
-
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
------
G
------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
35.18
45%
-137
- C5 -
-
1XJD
1
A:
[124-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
------
E
N
----
M
-----
L
----
G
D
---
A
KTN
F
----
C
G
T
P
D
Y
-
I
-
A
P
E
-
I
L
---
L
-
G
Q
K
-
Y
N
H
-
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
------
G
------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
35.16
45%
-135
- C5 -
-
5F9E
1
B:
[126-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
--
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
------
E
N
----
M
-----
L
GDAK
T
N
---
E
---
F
----
C
G
T
P
D
Y
-
I
-
A
P
E
-
I
L
---
L
-
G
Q
K
-
Y
N
H
-
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
------
G
------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
33.87
42%
-138
- C5 -
-
4RA4
1
A:
[127-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
E
I
S
I
G
L
F
F
L
H
K
R
G
--
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
------
E
H
----
M
-----
M
----
D
G
VTT
R
---
F
----
C
G
T
P
D
Y
-
I
-
A
P
E
-
I
I
---
A
-
Y
-
Q
P
Y
G
K
-
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
------
G
------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
31.99
32%
-96
- C5 -
-
5WDY
2
WNK1_HUMAN
B:
[127-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
G
L
Q
F
L
H
T
R
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L----
K
R
--------------------------------
T
P
E
F
-
M
-
A
P
E
-
M
Y
---
A
-
A
-
A
-
Y
D
E
-
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
------
S
E
----
Y
P
Y
S
E
----
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
-------
G
-------
S
F
D
K
V
---
A
I
P
E
V
K
E
I
I
E
G
C
----------------------------------------------------