@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRK4_HUMAN: (2021-11-22 )
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
Atome Classification :
(252 SA)
.........10........20....---....30........40----...--.....50........---60........70-----.-.......80........90-...-.....100.......110....---...120.......130.......140.......150.......160.......170.......180........190.......200......-----.210--.........220.-......230...---.---...240-.-...---....250.......260.......270.......280.........290.......300...-..-..310.......320.......330....-.-..340-.....-.----..350.......-360.......370.......380....---...390.......400.......410.......420.......430...-...-.440.-.......450.......460.......470.......480....--...490.......500.......510.......520.......530.......540.......550.......560.......570......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
L
E
N
I
V
A
N
S
L
L
L
K
ARQGGYGKKSG---R
S
K
K
W
K
E
ILTLP
P
V
S
Q
----
C
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
LCDK---Q
P
I
G
R
R
L
F
R
Q
F
C-----D-TK
P
T
L
K
R
H
I
E
F
L
D
A
V
A
EYE-VAD-DEDRSDC
G
L
S
I
L
D
R
F
FNDKLAA---PLPEI
P
P
D
V
V
T
E
C
RLGLKEENP
S
K
K
A
F
E
E
C
T
R
V
A
H
N
YLRGE
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
WLERQ-PVTK
N
T
F
R
H
Y
R
V
LGKGGFG
E
V
C
A
C
Q
V
RA-----TG----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
RKGEAMAL
N
E
---
K
---
R
I
L
E
-
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
YETKD
A
L
C
L
V
L
T
IMNGG
D
L
K
F
H
I
Y
NLG--NPGF
D
E
Q
R
A
V
F
Y
A
A
E
L
CC
G
L
E
D
L
Q
R
-
E
R
-
I
V
Y
RDLKPE
N
I
L
LDDRG
H
I
R
I
SDLGLATE-I-PEG-Q-RVRGR-V----GTVGYMA
P
E
VVN-NE
K
Y
T
FSP
D
W
W
G
L
G
C
L
I
Y
E
M
IQGHS
P
F
---
K
K
Y
K
E
KV
K
W
E
E
V
D
Q
R
I
KN
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
LTKNP
S
K
RLGC-RGE-GA-AG-VKQHPVFKDI
N
F
R
RLEANMLEPPFCPDP
H
A
V
Y
C
K
D
VL
D
I
E
Q
F
S
V
--
V
K
G
I
Y
LDTA
D
E
D
F
Y
A
R
F
ATGCVSIPW
Q
N
E
M
I
ESGCFKDINKSESEEALPLDLDKNIHTPVSRPN
R
G
F
F
Y
R
L
F
RRGG
C
L
TMVPSEKEVEPKQC
551
HHSearch
96.46
100%
-110
- C1 -
-
4YHJ
1
GRK4_HUMAN
A:
[25-525]
------------------------
G
---
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
----
C
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
-
T
K
P
T
L
K
R
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
-
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
N
D
K
L
A
A
---
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
R
I
L
E
-
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
P
G
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
A
T
E
-
I
-
P
E
G
-
Q
-
R
V
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
---
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
E
-
G
A
-
A
G
-
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
V
--
V
K
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
-----------------------------------------------------
1
PsiBlast_PDB
96.23
99%
-110
- C1 -
-
4YHJ
1
GRK4_HUMAN
A:
[25-525]
------------------------
G
---
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
----
C
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
-
T
K
P
T
L
K
R
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
-
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
N
D
K
L
A
A
---
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
R
I
L
E
-
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
P
G
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
A
T
E
-
I
-
P
E
G
-
Q
-
R
V
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
---
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
E
-
G
A
-
A
G
-
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
V
--
V
K
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
-----------------------------------------------------
552
HHSearch
94.55
100%
-113
- C1 -
-
4YHJ
1
GRK4_HUMAN
B:
[25-527]
------------------------
G
---
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
----
C
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
-
T
K
P
T
L
K
R
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
-
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
N
D
K
L
A
A
---
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
R
I
L
E
-
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
P
G
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
A
T
E
-
I
-
P
E
G
-
Q
-
R
V
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
---
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
E
-
G
A
-
A
G
-
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
---------------
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
N
K
---------------------------------------------------
21
Blastp_CBE
94.33
99%
-113
- C1 -
-
4YHJ
1
GRK4_HUMAN
B:
[25-527]
------------------------
G
---
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
----
C
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
-----
D
-
T
K
P
T
L
K
R
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
-
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
N
D
K
L
A
A
---
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
N
P
S
K
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
R
I
L
E
-
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
P
G
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
A
T
E
-
I
-
P
E
G
-
Q
-
R
V
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
N
-
N
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
F
---
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
E
-
G
A
-
A
G
-
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
D
P
H
A
V
Y
C
---------------
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
N
K
---------------------------------------------------
23
Blastp_CBE
93.00
67%
-110
- C1 -
-
3NYN
2
GRK6_HUMAN
B:
[2-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
----
C
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
-
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
-
T
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
---
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
-
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
-
P
K
K
G
L
L
Q
R
L
F
S
-------------------
22
Blastp_CBE
91.81
67%
-107
- C1 -
-
3NYO
2
GRK6_HUMAN
B:
[2-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
----
C
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
-
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
-
T
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
---
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
-
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
-
P
K
K
G
L
L
Q
R
L
F
S
-------------------
5
PsiBlast_PDB
91.48
66%
-104
- C1 -
-
3NYN
2
GRK6_HUMAN
A:
[2-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
----
C
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
-
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
-
T
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
---
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
-
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
-
P
K
K
G
L
L
Q
R
L
F
S
-------------------
556
HHSearch
91.28
65%
-107
- C1 -
-
3NYO
2
GRK6_HUMAN
B:
[2-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
----
C
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
-
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
-
T
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
---
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
-
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
-
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------
6
PsiBlast_PDB
90.99
66%
-106
- C1 -
-
3NYO
2
GRK6_HUMAN
A:
[2-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
----
C
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
-
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
-
T
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
---
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
-
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
-
P
K
K
G
L
L
Q
R
L
F
S
-------------------
2
PsiBlast_PDB
88.29
67%
-93
- C1 -
-
4TNB
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
G
G
G
K
R
K
G
---
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
----
C
E
D
--
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
-
T
R
P
G
L
E
C
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
-
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
P
V
---
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
-
P
C
K
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
-
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
-
P
E
G
-
D
-
L
I
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
---
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
E
-
E
A
-
A
E
-
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
--
H
P
P
--------------------------------
7
PsiBlast_PDB
87.27
66%
-112
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
--------------------
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
----
C
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
-
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
-
T
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
---
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
-
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
-------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
---------------------------------------------
4
PsiBlast_PDB
87.22
67%
-108
- C1 -
-
4WNK
1
GRK5_BOVIN
A:
[24-541]
-----------------------
K
G
---
K
S
K
K
W
K
E
I
L
K
F
P
H
I
N
Q
----
C
E
D
--
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
V
G
R
L
L
F
R
Q
F
C
-----
E
-
T
R
P
G
L
E
S
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
-
D
E
K
L
G
E
K
G
K
E
I
M
T
K
Y
L
T
P
K
S
P
V
---
F
I
T
Q
V
G
R
D
L
V
S
Q
T
E
E
K
L
L
Q
K
-
P
C
K
E
L
F
S
A
C
V
Q
S
V
H
D
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
Y
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
R
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
-
P
E
G
-
D
-
L
I
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
---
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
E
-
G
A
-
A
E
-
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
---------------------
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
P
I
P
W
Q
S
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
H
G
T
L
S
P
D
L
N
R
S
--
H
----------------------------------
3
PsiBlast_PDB
87.02
67%
-90
- C1 -
-
4TND
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
G
G
G
K
R
K
G
---
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
----
C
E
D
--
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
-
T
R
P
G
L
E
C
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
-
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
P
V
---
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
Q
K
-
P
C
K
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
-
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
-
P
E
G
-
D
-
L
I
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
---
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
E
-
E
A
-
A
E
-
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
--
H
P
P
--------------------------------
571
Fugue
87.01
66%
-112
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
--------------------
K
A
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
----
C
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
-
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
-
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
-
T
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
---
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
-
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
-------------------
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
---------------------------------------------
24
Blastp_CBE
86.55
67%
-109
- C1 -
-
2ACX
1
GRK6_HUMAN
B:
[14-535]
--------------------
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
----
C
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
-
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
---
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
-
T
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
---
Q
Q
---
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
-
S
A
-
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
--------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
------------------------------------------
550
HHSearch
76.95
67%
-12
- C1 -
-
4TND
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
G
G
G
K
R
K
G
---
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
----
C
E
D
--
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
I
G
R
L
L
F
R
Q
F
C
-----
E
-
T
R
P
G
L
E
C
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
-
E
K
G
K
K
I
M
T
K
Y
L
T
P
K
S
P
V
---
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
L
-
Q
K
P
C
K
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
E
---
K
---
Q
I
L
E
-
K
-
V
-
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
P
G
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
-
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
-
P
E
G
-
D
-
L
I
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
L
N
-
N
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
F
---
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
E
-
E
A
-
A
E
-
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
T
--
V
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
H
P
--
P
--------------------------------
18
PsiBlast_PDB
73.08
47%
-44
- C1 -
-
4L9I
2
GRK1_BOVIN
A:
[2-500]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
35
Blastp_CBE
72.75
48%
-46
- C1 -
-
4L9I
1
GRK1_BOVIN
B:
[2-500]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
----------
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
555
HHSearch
72.67
47%
-40
- C1 -
-
4L9I
2
GRK1_BOVIN
A:
[1-503]
------------------------
S
---
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
-----
A
R
A
G
A
G
D
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
-
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
-------------------------------------------------
570
Fugue
72.43
47%
-43
- C1 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
--------
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
-------
G
A
--
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
553
HHSearch
72.32
47%
-42
- C1 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
-----
R
A
G
---
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
-----
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
13
PsiBlast_PDB
71.87
47%
-43
- C1 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-529]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
-----
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
16
PsiBlast_PDB
71.52
47%
-44
- C1 -
-
3C4W
1
GRK1_BOVIN
A:
[31-529]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
---------
Q
D
V
G
A
F
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
15
PsiBlast_PDB
69.91
47%
-41
- C1 -
-
3C51
1
GRK1_BOVIN
A:
[31-529]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
-------------
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
30
Blastp_CBE
69.64
47%
-43
- C1 -
-
3C4X
1
GRK1_BOVIN
B:
[31-529]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
-------------
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
----------------------
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
28
Blastp_CBE
69.54
47%
-79
- C1 -
-
3C51
1
GRK1_BOVIN
B:
[31-529]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
---
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
---------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
--
D
I
R
Y
H
I
Y
---------
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
--
E
N
K
E
L
K
Q
R
V
-------
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
-----------------
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
14
PsiBlast_PDB
65.13
47%
13
- C1 -
-
3C50
2
GRK1_BOVIN
A:
[30-529]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
Q
D
-----
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
8
PsiBlast_PDB
64.72
46%
12
- C1 -
-
4PNI
1
GRK1_BOVIN
A:
[30-533]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
I
--------------
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------
9
PsiBlast_PDB
64.46
47%
11
- C1 -
-
3T8O
2
GRK1_BOVIN
A:
[30-529]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
K
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
-----
I
Q
D
V
G
A
F
-------
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
29
Blastp_CBE
64.42
47%
14
- C1 -
-
3C50
1
GRK1_BOVIN
B:
[30-529]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
--------
A
F
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
31
Blastp_CBE
64.11
47%
22
- C1 -
-
3C4W
1
GRK1_BOVIN
B:
[9-529]
-----
V
V
A
N
S
A
F
I
A
A
R
-
G
S
F
D
A
S
S
G
PAS
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
--
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
--------
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
11
PsiBlast_PDB
63.95
47%
10
- C1 -
-
3C4X
1
GRK1_BOVIN
A:
[30-529]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
----
C
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
-
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
---
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
-
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
-
S
C
-
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
--------
I
Q
D
V
G
A
F
S
T
--
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
----------------------------------------------------
39
Blastp_CBE
54.39
36%
22
- C1 -
-
3PVW
1
ARBK1_BOVIN
A:
[29-536]
------------------------------
S
K
---
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LKHLE
E
-
A
K
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
---------------------
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
38
Blastp_CBE
54.33
36%
17
- C1 -
-
5UKM
1
ARBK1_BOVIN
A:
[31-537]
-----------------------------------
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LKHLE
E
-
A
K
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
-----------
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
40
Blastp_CBE
54.19
36%
21
- C1 -
-
3PVU
1
ARBK1_BOVIN
A:
[30-536]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LKHLE
E
-
A
K
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
------------------------
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
557
HHSearch
51.49
36%
11
- C1 -
-
3V5W
1
ARBK1_HUMAN
A:
[30-540]
--------------------------------
K
K
I
L
L
P
E
P
S
I
R
S
----
V
M
Q
KY
L
E
D
R
G
E
V
T
F
E
K
I
F
S
----
Q
K
L
G
Y
L
L
F
R
D
F
C
-----
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
IML
S
L
V
S
-
T
-
G
-
D
C
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
----
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
---
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
---------
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
-------------------------------------------------
41
Blastp_CBE
51.35
38%
30
- C1 -
-
5HE3
1
ARBK1_BOVIN
A:
[32-501]
-----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
LKHLE
E
-
A
K
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
------------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
54
Blastp_CBE
51.30
36%
31
- C1 -
-
3KRW
1
ARBK1_HUMAN
A:
[29-536]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
H--
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
ED
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
560
HHSearch
51.21
37%
35
- C1 -
-
4MK0
1
ARBK1_HUMAN
A:
[2-504]
-----------------------------------
K
I
L
L
P
E
P
S
I
RSVM
Q
K
Y
--
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
---
Q
K
L
G
Y
L
L
F
R
D
F
C
-----
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
IML
S
L
V
S
-
T
-
G
-
D
C
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
----
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
---
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
-
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
---------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
-------------------------------------------------
48
Blastp_CBE
50.69
36%
29
- C1 -
-
5WG3
1
ARBK1_HUMAN
A:
[30-538]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
---
T
K
D
K
-
H
E
I
D
R
M
T
L
T
--
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
--------ED
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
53
Blastp_CBE
50.34
36%
30
- C1 -
-
3KRX
1
ARBK1_HUMAN
A:
[29-536]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
H--
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------
E
ED
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
52
Blastp_CBE
50.31
36%
31
- C1 -
-
6C2Y
1
ARBK1_HUMAN
A:
[30-532]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
--
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
------------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
47
Blastp_CBE
50.00
36%
27
- C1 -
-
5WG4
1
ARBK1_HUMAN
A:
[31-535]
-----------------------------------
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
--
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
----------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
50
Blastp_CBE
49.87
36%
30
- C1 -
-
3V5W
1
ARBK1_HUMAN
A:
[30-537]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
---------
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
49
Blastp_CBE
49.69
36%
36
- C1 -
-
4PNK
1
ARBK1_HUMAN
A:
[30-530]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-
E
V
N
A
-------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
43
Blastp_CBE
49.20
38%
29
- C1 -
-
5HE0
1
ARBK1_BOVIN
A:
[32-501]
-----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
LKHLE
E
-
A
K
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
------------------
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
46
Blastp_CBE
48.85
36%
28
- C1 -
-
5WG5
1
ARBK1_HUMAN
A:
[30-534]
-------------------------------
K
---
K
I
L
L
P
E
P
S
I
----
R
S
V
--
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
----
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
---
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
---
V
N
A
A
D
A
F
-------D-
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
561
HHSearch
48.73
37%
37
- C1 -
-
5UKL
1
ARBK1_HUMAN
A:
[2-504]
-----------------------------------
K
I
L
L
P
E
P
S
I
RSVM
Q
K
Y
--
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
---
Q
K
L
G
Y
L
L
F
R
D
F
C
-----
L
N
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
-
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
IML
S
L
V
S
-
T
-
G
-
D
C
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
----
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
---
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
-----------
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
-------------------------------------------------
55
Blastp_CBE
48.61
38%
20
- C1 -
-
4MK0
1
ARBK1_HUMAN
A:
[32-501]
-----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
---------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
56
Blastp_CBE
47.47
38%
18
- C1 -
-
5UKL
1
ARBK1_HUMAN
A:
[32-501]
-----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
D
-----------
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
58
Blastp_CBE
47.41
38%
26
- C1 -
-
5HE1
1
ARBK1_HUMAN
A:
[33-505]
-----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
CSH
P
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
-------------------
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
42
Blastp_CBE
47.38
38%
35
- C1 -
-
5HE2
1
ARBK1_BOVIN
A:
[32-501]
-----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
LKHLE
E
-
A
K
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
---
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
-----------
G
S
F
D
E
ED
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
559
HHSearch
46.51
36%
36
- C1 -
-
5UVC
1
ARBK1_HUMAN
A:
[39-542]
----------------------------------
K
K
I
L
L
P
E
P
S
I
RSVM
Q
K
Y
--
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
---
Q
K
L
G
Y
L
L
F
R
D
F
C
L----
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
-
K
L
E
-----
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
-------------------------
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
RIM
L
---
S
L
V
S
-
T
-
G
-
D
C
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
----
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
---
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
-
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
-----------------------
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
-------------------------------------------------
81
Blastp_CBE
46.43
39%
-69
- C1 -
-
2X39
1
AKT2_HUMAN
A:
[7-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
46.34
38%
32
- C1 -
-
5UKK
1
ARBK1_HUMAN
A:
[32-501]
-----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
---------
F
S
K
S
A
T
E
H
V
-
Q
G
H
L
G
K
K
Q
V
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
N
A
A
D
A
F
----------------
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
80
Blastp_CBE
45.79
39%
-73
- C1 -
-
2XH5
1
AKT2_HUMAN
A:
[7-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
45.59
39%
-66
- C1 -
-
2UW9
1
AKT2_HUMAN
A:
[7-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
45.45
39%
-65
- C1 -
-
2JDR
1
AKT2_HUMAN
A:
[7-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
44.91
38%
31
- C1 -
-
5UVC
1
ARBK1_HUMAN
A:
[70-539]
-----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
LNHLE
E
-
A
R
P
L
----
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
------
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
-----------------------
P
P
D
--
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
-----------------------
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
45
Blastp_CBE
43.98
38%
14
- C1 -
-
5UUU
2
ARBK1_HUMAN
A:
[40-539]
---------------------------------------------------------------------------
Y
L
L
F
R
D
F
C
L-------
R
P
L
----
V
E
F
Y
E
E
---------------
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
-----------------
G
H
L
----------
L
F
Q
P
Y
---
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
-
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
--
K
-
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
-------------ED
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
----------------------------------------------------
319
Blastp_CBE
43.79
35%
-63
- C1 -
-
2F7Z
1
KAPCA_BOVIN
E:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
43.55
35%
-61
- C1 -
-
2OH0
1
KAPCA_BOVIN
E:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
43.37
35%
-63
- C1 -
-
2UZU
1
KAPCA_BOVIN
E:
[27-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
43.23
35%
-62
- C1 -
-
2UZT
1
KAPCA_BOVIN
A:
[27-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
43.22
35%
-59
- C1 -
-
2OJF
1
KAPCA_BOVIN
E:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
43.20
35%
-61
- C1 -
-
2UZW
1
KAPCA_BOVIN
E:
[27-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
558
HHSearch
43.04
36%
25
- C1 -
-
5UUU
2
ARBK1_HUMAN
A:
[40-542]
-----------------------------------
K
I
L
L
P
E
P
S
I
RSVM
Q
K
Y
--
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
---
Q
K
L
G
Y
L
L
F
R
D
F
C
L----
N
--------------------------------------------------------------------------------------
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
IML
S
L
V
S
-
T
-
G
-
D
C
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
----
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
---
K
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
---
R
Q
H
K
T
K
D
-
K
H
E
I
D
R
M
T
L
T
M
A
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
-
G
A
-
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
E
V
-------------ED
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
-------------------------------------------------
216
Blastp_CBE
42.87
35%
-56
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[27-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
42.60
35%
-57
- C1 -
-
2F7E
1
KAPCA_BOVIN
E:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
40.73
34%
-64
- C1 -
-
5LCU
5
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
40.63
33%
-63
- C1 -
-
4NTT
1
KAPCA_MOUSE
A:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
40.56
34%
-62
- C1 -
-
5M71
2
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
40.52
35%
-63
- C1 -
-
1YDR
1
KAPCA_BOVIN
E:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
40.48
34%
-62
- C1 -
-
3RWP
5
PDPK1_HUMAN
A:
[34-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S----------
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
40.47
34%
-63
- C1 -
-
2PE2
9
PDPK1_HUMAN
A:
[9-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S-----------F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
40.41
34%
-61
- C1 -
-
2PE1
5
PDPK1_HUMAN
A:
[9-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S-----------F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
40.27
34%
-63
- C1 -
-
5M75
2
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
40.25
34%
-62
- C1 -
-
3SC1
3
PDPK1_HUMAN
A:
[34-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S---------
A
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
40.25
35%
-64
- C1 -
-
1Q8U
3
KAPCA_BOVIN
A:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
40.25
34%
-61
- C1 -
-
5LCT
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
40.25
39%
-20
- C1 -
-
3OW4
1
AKT1_HUMAN
B:
[6-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
40.20
34%
-63
- C1 -
-
5N1D
3
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
--
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
40.10
34%
-65
- C1 -
-
2PE0
4
PDPK1_HUMAN
A:
[9-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S-----------F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
40.09
34%
-59
- C1 -
-
6C0U
4
KAPCA_HUMAN
A:
[33-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
40.03
39%
-22
- C1 -
-
6CCY
1
AKT1_HUMAN
A:
[5-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
S
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
39.99
39%
-21
- C1 -
-
3CQU
1
AKT1_HUMAN
A:
[7-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
39.98
39%
-24
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[5-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
39.96
39%
-20
- C1 -
-
4EKK
1
AKT1_HUMAN
A:
[6-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
39.94
34%
-60
- C1 -
-
5LCP
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
39.93
39%
-22
- C1 -
-
3OCB
1
AKT1_HUMAN
B:
[6-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
39.90
34%
-58
- C1 -
-
3OVV
2
KAPCA_HUMAN
A:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
39.86
34%
-65
- C1 -
-
3IOP
1
PDPK1_HUMAN
A:
[35-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S----------
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
39.80
34%
-59
- C1 -
-
5M6V
1
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
39.79
34%
-58
- C1 -
-
5M6Y
2
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
39.76
34%
-57
- C1 -
-
4UJ2
2
KAPCA_HUMAN
A:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
39.75
34%
-60
- C1 -
-
3L9L
1
KAPCA_HUMAN
B:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
39.70
34%
-56
- C1 -
-
3OWP
1
KAPCA_HUMAN
A:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
563
HHSearch
39.65
38%
-22
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[5-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
-
G
-
I
K
D
G
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
E
----
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
-------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
39.63
39%
-23
- C1 -
-
3QKK
1
AKT1_HUMAN
A:
[6-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
39.62
40%
-49
- C1 -
-
3TXO
1
A:
[23-303]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
-----
T
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
-
L
Q
D
D
D
V
E
C
T
M
T
E
---
K
---
R
I
L
S
-
L
-
A
-
R
N
H
P--
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
----
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
-------------
C
----
G
T
P
D
Y
I
A
P
E
I
L
Q
-
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
---
E
A
E
N
E
----
D
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
-
L
T
Q
-
G
G
E
H
A
-
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
----------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
39.59
33%
-66
- C1 -
-
3NX8
3
KAPCA_HUMAN
A:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
-
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
39.54
34%
-65
- C1 -
-
1Q8W
1
KAPCA_BOVIN
A:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
39.53
33%
-56
- C1 -
-
4IB3
1
KAPCA_MOUSE
A:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
39.43
34%
-56
- C1 -
-
2XCH
7
PDPK1_HUMAN
A:
[32-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S---------
A
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
39.43
34%
-57
- C1 -
-
4UJ1
2
KAPCA_HUMAN
A:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
39.38
39%
-18
- C1 -
-
4EKK
1
AKT1_HUMAN
B:
[6-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
39.35
34%
-57
- C1 -
-
5LCR
6
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
39.34
34%
-59
- C1 -
-
1UU8
7
PDPK1_HUMAN
A:
[32-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S---------
A
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
39.32
33%
-63
- C1 -
-
4IAK
1
KAPCA_MOUSE
A:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
39.30
34%
-56
- C1 -
-
1UU9
8
PDPK1_HUMAN
A:
[11-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S----------
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
39.30
39%
-16
- C1 -
-
3QKL
1
AKT1_HUMAN
A:
[6-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
39.28
39%
-19
- C1 -
-
3OCB
1
AKT1_HUMAN
A:
[6-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
39.27
34%
-56
- C1 -
-
3OXT
1
KAPCA_HUMAN
A:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
39.23
34%
-62
- C1 -
-
2GNL
1
KAPCA_BOVIN
A:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
39.22
39%
-19
- C1 -
-
4EKL
1
AKT1_HUMAN
A:
[6-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
39.21
35%
-60
- C1 -
-
1Q8T
1
KAPCA_BOVIN
A:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
39.21
33%
-58
- C1 -
-
3OW3
1
KAPCA_MOUSE
A:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
39.12
39%
-18
- C1 -
-
3CQW
1
AKT1_HUMAN
A:
[7-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
39.04
39%
-16
- C1 -
-
3MV5
1
AKT1_HUMAN
A:
[7-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
39.03
34%
-61
- C1 -
-
5M0U
10
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
----
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
39.01
33%
-60
- C1 -
-
3IDC
1
KAPCA_MOUSE
A:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
38.93
35%
-61
- C1 -
-
2GNF
1
KAPCA_BOVIN
A:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
38.92
35%
-59
- C1 -
-
3ZO4
4
KAPCA_BOVIN
A:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
38.89
33%
-58
- C1 -
-
4DG0
2
KAPCA_MOUSE
E:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
38.90
35%
-61
- C1 -
-
4YXS
1
KAPCA_BOVIN
A:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
38.89
33%
-56
- C1 -
-
5N3N
4
KAPCA_CRIGR
A:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
38.86
35%
-62
- C1 -
-
2C1B
1
KAPCA_BOVIN
A:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
38.84
33%
-59
- C1 -
-
4HPT
1
KAPCA_MOUSE
E:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
38.82
33%
-55
- C1 -
-
6EM7
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
38.82
35%
-62
- C1 -
-
2GNH
2
KAPCA_BOVIN
A:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
38.82
39%
-48
- C1 -
-
3E87
1
AKT2_HUMAN
B:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
38.74
33%
-59
- C1 -
-
2GU8
1
KAPCA_HUMAN
A:
[16-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
E
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
38.74
35%
-60
- C1 -
-
2GNI
1
KAPCA_BOVIN
A:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
38.70
33%
-58
- C1 -
-
1RDQ
3
KAPCA_MOUSE
E:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
A
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
38.70
33%
-60
- C1 -
-
2QUR
1
KAPCA_MOUSE
A:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
P
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
38.70
39%
-18
- C1 -
-
3OW4
1
AKT1_HUMAN
A:
[6-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
38.67
35%
-60
- C1 -
-
4IE9
2
KAPCA_BOVIN
A:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
38.67
39%
-30
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[7-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
S
-
L
-
A
W
E
H
P
---
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
-
N
-
M
L
G
-
D
A
K
T
N
E
F
-
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
---
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
D
-------
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
----------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
38.66
33%
-55
- C1 -
-
4IAI
2
KAPCA_MOUSE
A:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
38.61
33%
-59
- C1 -
-
4IAY
1
KAPCA_MOUSE
A:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
38.60
39%
-48
- C1 -
-
3E87
1
AKT2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
38.59
33%
-57
- C1 -
-
4HPU
2
KAPCA_MOUSE
E:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
38.56
35%
-65
- C1 -
-
1STC
1
KAPCA_BOVIN
E:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
38.48
33%
-53
- C1 -
-
4IB0
1
KAPCA_MOUSE
A:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
38.47
34%
-57
- C1 -
-
5N1K
3
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
--
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
------
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
38.45
39%
-26
- C1 -
-
5F9E
1
KPCT_HUMAN
A:
[21-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
S
-
L
-
A
W
E
H
P
---
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
-
N
-
M
L
G
-
D
A
K
T
N
E
F
-
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
---
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
D
-------
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
----------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
38.44
33%
-56
- C1 -
-
4IAD
1
KAPCA_MOUSE
A:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
38.43
33%
-57
- C1 -
-
3X2V
1
KAPCA_MOUSE
A:
[36-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
38.40
33%
-56
- C1 -
-
4DFX
5
KAPCA_MOUSE
E:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
38.39
33%
-55
- C1 -
-
1L3R
3
KAPCA_MOUSE
E:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
38.37
39%
-47
- C1 -
-
1O6K
1
AKT2_HUMAN
A:
[2-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
38.34
33%
-57
- C1 -
-
4XW6
1
KAPCA_MOUSE
A:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
38.35
39%
-27
- C1 -
-
4Q9Z
1
KPCT_HUMAN
A:
[7-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
S
-
L
-
A
W
E
H
P
---
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
-
N
-
M
L
G
-
D
A
K
T
N
E
F
-
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
---
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
D
-------
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
----------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
38.34
33%
-57
- C1 -
-
2ERZ
1
KAPCA_MOUSE
E:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
38.30
35%
-59
- C1 -
-
1SMH
6
KAPCA_BOVIN
A:
[41-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
E
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
38.20
39%
-44
- C1 -
-
3E8D
1
AKT2_HUMAN
B:
[2-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
38.15
39%
-46
- C1 -
-
1O6L
1
AKT2_HUMAN
A:
[2-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
38.14
39%
-44
- C1 -
-
3D0E
1
AKT2_HUMAN
B:
[2-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
38.13
33%
-53
- C1 -
-
4DIN
1
KAPCA_MOUSE
A:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
38.11
33%
-52
- C1 -
-
4IB1
1
KAPCA_MOUSE
A:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
38.08
33%
-55
- C1 -
-
2QCS
5
KAPCA_MOUSE
A:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
38.07
33%
-53
- C1 -
-
4DH5
1
KAPCA_MOUSE
A:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
38.05
34%
-54
- C1 -
-
1JBP
2
KAPCA_MOUSE
E:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
-
D
E
P
I
---
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
38.03
39%
-43
- C1 -
-
3E8D
1
AKT2_HUMAN
A:
[2-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
37.95
33%
-56
- C1 -
-
3X2W
1
KAPCA_MOUSE
A:
[36-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
37.83
39%
-45
- C1 -
-
3D0E
1
AKT2_HUMAN
A:
[2-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
37.82
34%
-59
- C1 -
-
4C37
2
KAPCA_BOVIN
A:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
37.74
39%
-46
- C1 -
-
3E88
1
AKT2_HUMAN
A:
[2-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
37.67
39%
-46
- C1 -
-
3E88
1
AKT2_HUMAN
B:
[2-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
-
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
-
T
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
R
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
-
D
A
-
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
37.43
33%
-50
- C1 -
-
4XW4
1
KAPCA_MOUSE
A:
[35-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
--
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
36.67
34%
-65
- C1 -
-
1UVR
8
PDPK1_HUMAN
A:
[12-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S
P
------
A
R
A
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
36.42
34%
-60
- C1 -
-
3RWQ
4
PDPK1_HUMAN
A:
[34-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
-
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
--
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
-
L
S
P
------
A
R
A
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
-
E
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
---
R
A
G
N
E
Y
L
----
I
F
Q
K
I
I
K
L
E
Y
D
F
P
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
-
G
Y
-
G
P
-
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
T
--
P
P
-------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
35.80
39%
-55
- C1 -
-
3O96
1
AKT1_HUMAN
A:
[114-430]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
-------------
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
----------------------
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
35.71
39%
-28
- C1 -
-
6HHJ
1
AKT1_HUMAN
A:
[112-427]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
-
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
35.20
39%
-52
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[117-441]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
------------------------
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
------------------------
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
34.68
39%
-33
- C1 -
-
1XJD
1
A:
[19-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
S
-
L
-
A
W
E
H
P
---
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
--
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
-
N
-
M
L
G
-
D
-
A
K
T
N
F
-
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
-
G
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
---
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
D
-------
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
----------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
34.60
39%
-52
- C1 -
-
6HHF
1
AKT1_HUMAN
A:
[111-427]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
---------------------------
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
----------------------
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
34.53
41%
-29
- C1 -
-
4OTI
1
A:
[5-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
S
-
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
F
R
P
-----
S
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
-
V
A
R
D
E
V
E
S
L
M
C
E
---
K
---
R
I
L
A
-
A
-
V
-
T
S
A
GHP
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-----
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
-
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
----------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
---
P
G
D
D
E
----
E
E
V
F
D
S
I
V
N
D
E
V
R
Y
P
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
-
S
E
R
-
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
----------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
34.39
41%
-25
- C1 -
-
4OTH
1
A:
[5-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
S
-
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
F
R
P
-----
S
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
-
V
A
R
D
E
V
E
S
L
M
C
E
---
K
---
R
I
L
A
-
A
-
V
-
T
S
A
GHP
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-----
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
-
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
--------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
---
P
G
D
D
E
----
E
E
V
F
D
S
I
V
N
D
E
V
R
Y
P
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
-
S
E
R
-
D
A
-
E
D
-
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
----------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
32.95
39%
-35
- C1 -
-
3HDN
1
SGK1_HUMAN
A:
[40-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-------------------
V
L
L
-
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
----
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
-
S
-
T
T
S
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-----
Y
S
R
N
T
A
--
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
D
D
-
F
M
-
E
--
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
----------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
32.89
39%
-34
- C1 -
-
2R5T
1
SGK1_HUMAN
A:
[40-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-------------------
V
L
L
-
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
----
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
-
S
-
T
T
S
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-----
Y
S
R
N
T
A
--
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
D
D
-
F
M
-
E
--
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
---------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
32.64
39%
-25
- C1 -
-
6HHG
1
AKT1_HUMAN
A:
[111-427]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
---------------------------
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
-----
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
32.57
32%
-40
- C1 -
-
5LIH
3
KPCI_HUMAN
B:
[7-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
K
-----
T
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
----------
V
Q
T
E
---
K
---
H
V
F
E
-
Q
-
A
-
S
N
H
P--
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
----
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
-
G
-
L
R
P
-
G
-
D
T
T
S
F
-
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
-
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DI---------
E
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
-
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
-----------------------------------------------------------------------------------------------
94
Blastp_CBE
32.47
39%
-26
- C1 -
-
6HHI
1
AKT1_HUMAN
A:
[111-427]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-----------------------
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
-----
T
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
32.37
39%
-31
- C1 -
-
3HDM
1
SGK1_HUMAN
A:
[40-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-------------------
V
L
L
-
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
----
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
-
S
-
T
T
S
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
-----
Y
S
R
N
T
A
--
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
D
D
-
F
M
-
E
--
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
---------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
32.12
39%
-13
- C1 -
-
3PFQ
1
KPCB_RAT
A:
[343-620]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
R
K
G
-----
T
D
----
E
L
Y
A
V
K
I
L
K
K
D
V
V
-
I
Q
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
A
L
P
-
G
-
K
P
P
---
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
G
--
R
--
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
-
N
-
I
W
D
-
G
-
V
T
T
K
F
-
C
----
G
T
P
D
Y
I
A
P
E
I
I
A
-
Y
Q
P
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
---
E
G
E
D
E
----
D
E
L
F
Q
S
I
M
E
H
N
V
A
Y
P
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
C
-
G
P
E
-
G
E
-
R
D
-
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
----------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
31.71
39%
-21
- C1 -
-
6HHH
1
AKT1_HUMAN
A:
[111-427]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
---------------------
R
V
L
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G-------------------
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
31.63
33%
-31
- C1 -
-
5N1L
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
--
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
31.61
32%
-26
- C1 -
-
5LIH
3
KPCI_HUMAN
A:
[7-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
K
-----
T
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
--------
W
V
Q
T
E
---
K
---
H
V
F
E
-
Q
-
A
-
S
N
H
P--
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
----
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
-
G
-
L
R
P
-
G
-
D
T
T
S
F
-
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
-
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DIV------
N
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
-
A
D
-
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
T
-----------------------------------------------------------------------------------------------
134
Blastp_CBE
31.52
39%
3
- C1 -
-
4L3J
1
KS6B1_HUMAN
A:
[20-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
-
T
-
V
T
H
T
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
31.51
39%
-26
- C1 -
-
6S9X
1
?
A:
[110-427]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-----------------------
Q
-
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
---------
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
----
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
-
D
A
-
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
31.46
33%
-31
- C1 -
-
6EMA
2
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
31.38
33%
-29
- C1 -
-
5N3E
3
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
-
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
31.17
33%
-29
- C1 -
-
5N3A
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
31.04
39%
4
- C1 -
-
4L3L
1
KS6B1_HUMAN
A:
[20-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
-
T
-
V
T
H
T
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
30.99
39%
1
- C1 -
-
4L45
1
KS6B1_HUMAN
A:
[20-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S-------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
30.98
39%
8
- C1 -
-
4L42
1
KS6B1_HUMAN
A:
[20-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
-
T
-
V
T
H
T
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
30.81
39%
1
- C1 -
-
4L46
1
KS6B1_HUMAN
A:
[20-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
------
H
T
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
30.58
39%
3
- C1 -
-
4L43
1
KS6B1_HUMAN
A:
[20-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S-------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
29.44
39%
18
- C1 -
-
3WE4
1
KS6B1_HUMAN
A:
[21-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-
S
-
I
H
D
----
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
29.37
38%
-2
- C1 -
-
6G78
1
KS6A6_HUMAN
B:
[31-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------------
D
I
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
-
K
D
R
N
E
T
M
N
M
I
L
K
A
K
L
G
M
P
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
---
E
-
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
28.83
38%
-0
- C1 -
-
6G78
1
KS6A6_HUMAN
A:
[31-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------------
D
I
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
-
D
Q
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
-
K
D
R
N
E
T
M
N
M
I
L
K
A
K
L
G
M
P
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
---
E
-
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
28.54
38%
-2
- C1 -
-
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
-------------------------
I
L
A
-
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
D
R
K
----
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
D
-
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
28.39
39%
21
- C1 -
-
3WF7
2
KS6B1_HUMAN
A:
[21-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-
S
-
I
H
D
----
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
28.26
38%
10
- C1 -
-
6G77
2
KS6A6_HUMAN
A:
[31-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------------
D
I
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
-
D
Q
E
-
K
-
K
A
Y
S
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
-
K
D
R
N
E
T
M
N
M
I
L
K
A
K
L
G
M
P
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
---
E
-
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
27.93
38%
15
- C1 -
-
6G77
2
KS6A6_HUMAN
B:
[31-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------------
D
I
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
-
D
Q
E
-
K
-
K
A
Y
S
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
-
K
D
R
N
E
T
M
N
M
I
L
K
A
K
L
G
M
P
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
---
E
-
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
27.92
38%
-1
- C1 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
--------------------------
I
L
A
-
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
D
R
K
----
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
D
-
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
27.88
39%
2
- C1 -
-
3WF8
2
KS6B1_HUMAN
A:
[21-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-
S
-
I
H
D
-
G
-
T
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
27.65
39%
1
- C1 -
-
3WF9
2
KS6B1_HUMAN
A:
[21-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-
S
-
I
H
D
-
G
-
T
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
27.53
38%
10
- C1 -
-
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
------------------
I
L
A
-
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
G
K
D
R
K
----
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
D
-
G
A
-
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
27.40
39%
11
- C1 -
-
3A62
1
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
--------------
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-------------
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
26.64
39%
1
- C1 -
-
3A61
1
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
---------------
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
26.60
38%
25
- C1 -
-
5D9L
2
KS6A3_HUMAN
A:
[30-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
-
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
R
T
K
M
-
E
---
R
---
D
I
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
-
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
25.94
38%
-1
- C1 -
-
6G76
1
KS6A6_HUMAN
B:
[31-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
-------------
R
---
D
I
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
-
S
-
V
D
-----------------
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
-
K
D
R
N
E
T
--------
L
G
M
P
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
---
E
-
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
25.34
38%
3
- C1 -
-
6G76
2
KS6A6_HUMAN
A:
[31-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------------
D
I
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
-
S
-
V
D
Q
-
E
-
K
K
A
Y
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
-
K
D
R
N
E
T
M
N
M
I
L
K
A
K
L
G
M
P
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
---
E
-
G
V
-
E
E
-
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
25.32
39%
8
- C1 -
-
3A60
1
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
-----------
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
---------------------
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
25.28
34%
-39
- C1 -
-
4C36
1
KAPCA_BOVIN
A:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
25.26
33%
-32
- C1 -
-
6ESA
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
25.18
33%
-32
- C1 -
-
5NW8
2
KAPCA_CRIGR
A:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
25.18
33%
-31
- C1 -
-
4WB5
1
KAPCA_HUMAN
A:
[29-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
25.09
38%
20
- C1 -
-
3G51
1
KS6A3_MOUSE
A:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
-
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-------------
R
---
D
I
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-------------------
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
-
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
24.98
34%
-35
- C1 -
-
3ZO1
7
KAPCA_BOVIN
A:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
24.97
33%
-30
- C1 -
-
5N1H
3
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
24.97
33%
-30
- C1 -
-
6EMB
1
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
24.96
33%
-30
- C1 -
-
6I2A
1
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
24.94
33%
-30
- C1 -
-
5OUC
2
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
24.91
33%
-30
- C1 -
-
5N1F
3
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
24.89
33%
-30
- C1 -
-
5N3M
6
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
24.87
34%
-34
- C1 -
-
3ZO2
4
KAPCA_BOVIN
A:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
24.84
33%
-29
- C1 -
-
5N3L
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
24.83
33%
-29
- C1 -
-
5N3T
5
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
24.73
33%
-28
- C1 -
-
5N3J
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
24.69
33%
-28
- C1 -
-
5N3Q
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
24.67
34%
-32
- C1 -
-
3ZO3
9
KAPCA_BOVIN
A:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
24.63
33%
-28
- C1 -
-
5N3G
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
24.60
33%
-29
- C1 -
-
5N37
6
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
24.52
33%
-27
- C1 -
-
5OT3
3
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
24.49
33%
-27
- C1 -
-
5N3S
5
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
24.46
33%
-26
- C1 -
-
5N3P
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
24.40
34%
-32
- C1 -
-
4C35
2
KAPCA_BOVIN
A:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
24.40
33%
-26
- C1 -
-
5N3O
6
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
24.37
33%
-26
- C1 -
-
5N1G
4
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
24.31
33%
-25
- C1 -
-
5N3R
3
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
24.21
34%
-29
- C1 -
-
2JDS
1
KAPCA_BOVIN
A:
[42-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
24.13
33%
-28
- C1 -
-
6ERW
2
KAPCA_CRIGR
A:
[32-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
---
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
-
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
---
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
---------
K
-
R
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
---
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
-
G
V
-
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
----------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
23.03
38%
23
- C1 -
-
3UBD
1
KS6A3_MOUSE
A:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
-
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
-------------
D
I
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
------
E
-
K
-
K
A
Y
S
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
-
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
22.60
38%
22
- C1 -
-
4GUE
1
KS6A3_MOUSE
A:
[25-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
-
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
---------------
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
------
E
-
K
-
K
A
Y
S
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
-
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
22.59
39%
21
- C1 -
-
3WF5
1
KS6B1_HUMAN
A:
[21-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-
S
-
I
H
D
-
G
-
T
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
22.47
39%
22
- C1 -
-
3WF6
1
KS6B1_HUMAN
A:
[21-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
---
R
---
N
I
L
E
-
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-
S
-
I
H
D
-
G
-
T
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
22.22
38%
34
- C1 -
-
4EL9
1
KS6A3_MOUSE
A:
[25-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
-
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
---------
R
---
D
I
L
V
-
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S----
E
-
K
-
K
A
Y
S
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
-
G
V
-
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
19.95
39%
24
- C1 -
-
3A60
1
KS6B1_HUMAN
B:
[19-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
--------------------------------
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S--------------
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
19.50
39%
24
- C1 -
-
4RLO
4
KS6B1_HUMAN
B:
[7-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
--------------------------------
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-------------------
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
---
T
G
E
N
R
K
K
T
I
D
K
I
-
L
K
C
K
L
N
L
P
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P
-
G
D
-
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------------------------------------------------------------