@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRK6_HUMAN: (2021-11-22 )
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
Atome Classification :
(237 SA)
.........10.......--.20........30........40.----..--.....50........---60........70-.-.-......-80........90-...-.....100.......110-----...-......120.......130.-..-....-----140.......150.......160.......170......-.-180.......190.......200.....-----..----210.......220-.......230..---.---....240-...---.....250.......260.......270.......--280..-.......290.......300..-..-...310.......320.......330---.-.-.-....-340-....-.----...350.....-.-.-360.......370.......380..-.---....390.......400.....--..410.......420.......430..-.....-440........450.......460.....-----------..470.......480..--.--.-...490.......500.......510.......520.......530.......540.......550.......560.......570....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
L
E
N
I
VAN
T
V
L
L
K
A
REG--GGGNRKGK
S
K
K
W
R
Q
M
LQFPH
I
S
Q
C
----
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
ER---Q
P
I
G
R
L
L
F
R
E
F
C-A-T-
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
AEYE-VT
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------SHT-G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L-EQ-G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
LSV
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
LER-Q-PV
T
K
N
T
F
R
Q
Y
R
V
LGKGGFG
E
V
C
A
C
Q
V
RA-----TG----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
RKGEAMAL
N
E
---
K
---
Q
I
L
E
K
-V-NS
R
---
F
V
V
S
L
A
Y
A
YETKD
A
L
C
L
V
L
T
LMNGG
D
L
K
F
H
I
Y
HMG--Q--AG-F
P
E
A
R
A
V
F
Y
A
A
E
I
CC
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
RDLKPE
N
I
L
LDDHG
H
I
R
I
S
D
L
G
L
---
A
-
V
-H-VPEG-
Q
-
T
-IKGR-V----GTVGYM
A
P
E
V
V-K-N-E
R
Y
T
FS
P
D
W
W
A
L
G
C
L
L
Y
E
M
IAGQS
P
-
F
---
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
--
Y
S
E
RF
S
P
Q
A
R
S
L
C
S
Q
L
L
CKD
P
A
E
R
LGC-RGGS
A
-
R
-
E
V
K
EHP
L
F
K
KL
N
F
K
R
LGAGMLEPPFKP-----------DP
Q
A
I
Y
C
K
D
VL
D
I
E
Q
FS--T--V-KGVELEPT
D
Q
D
F
Y
Q
K
FATGSVPIPWQNEM
V
E
T
E
C
F
Q
E
L
NVFGLDGSVPPDLDWKGQPPAP
P
K
K
G
L
L
Q
R
L
F
S
RQDCCGNCSD
S
E
E
ELPTRL
22
Blastp_CBE
98.80
100%
-112
- C1 -
-
3NYN
2
GRK6_HUMAN
B:
[2-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
----
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-
A
-
T
-
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
-
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
H
-
V
P
E
G
-
Q
-
T
-
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
-
N
-
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
---
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
--
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
S
A
-
R
-
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
--
V
-
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------
1
PsiBlast_PDB
98.43
100%
-107
- C1 -
-
3NYN
2
GRK6_HUMAN
A:
[2-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
----
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-
A
-
T
-
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
-
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
H
-
V
P
E
G
-
Q
-
T
-
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
-
N
-
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
---
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
--
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
S
A
-
R
-
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
--
V
-
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------
2
PsiBlast_PDB
97.97
100%
-109
- C1 -
-
3NYO
2
GRK6_HUMAN
A:
[2-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
----
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-
A
-
T
-
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
-
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
H
-
V
P
E
G
-
Q
-
T
-
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
-
N
-
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
---
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
--
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
S
A
-
R
-
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
--
V
-
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------
554
HHSearch
97.38
100%
-109
- C1 -
-
3NYO
2
GRK6_HUMAN
B:
[2-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
----
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-
A
-
T
-
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
-
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
H
-
V
P
E
G
-
Q
-
T
-
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
-
N
-
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
---
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
--
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
S
A
-
R
-
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
--
V
-
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------
21
Blastp_CBE
97.38
100%
-109
- C1 -
-
3NYO
2
GRK6_HUMAN
B:
[2-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
--
G
G
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
----
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
Q
P
I
G
R
L
L
F
R
E
F
C
-
A
-
T
-
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
-
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
H
-
V
P
E
G
-
Q
-
T
-
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
-
N
-
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
---
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
--
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
S
A
-
R
-
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
--
V
-
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
-------------------
3
PsiBlast_PDB
91.13
99%
-118
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
----------------------
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
----
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
-
A
-
T
-
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
-
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
H
-
V
P
E
G
-
Q
-
T
-
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
-
N
-
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
---
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
--
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
S
A
-
R
-
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------
D
P
Q
A
I
Y
C
----------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
--------------------------------------------
571
Fugue
90.74
98%
-117
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
----------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
----
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
-
A
-
T
-
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
-
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
--
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
H
-
V
P
E
G
-
Q
-
T
-
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
-
N
-
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
---
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
--
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
S
A
-
R
-
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------
D
P
----------------------
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
--------------------------------------------
23
Blastp_CBE
90.05
99%
-115
- C1 -
-
2ACX
1
GRK6_HUMAN
B:
[14-535]
----------------------
G
N
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
----
E
E
--
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
---
N
P
I
G
R
L
L
F
R
E
F
C
-
A
-
T
-
R
P
E
L
S
R
-
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
T
P
-
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
-------
S
H
T
-
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
-
E
Q
-
G
P
C
K
-----
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
------
A
G
-
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
H
-
V
P
E
G
-
Q
-
T
-
I
K
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
K
-
N
-
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
-
F
---
Q
Q
---
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
--
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
-
R
G
G
S
A
-
R
-
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
-----------
D
P
Q
A
I
Y
-----------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
-----------------------------------------
5
PsiBlast_PDB
85.67
72%
-96
- C1 -
-
4TNB
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
--
G
G
G
K
R
K
G
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
C
----
E
D
--
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
I
G
R
L
L
F
R
Q
F
C
-
E
-
T
-
R
P
G
L
E
C
-
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
-
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
-------
T
P
K
-
S
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
-
L
Q
-
K
P
C
K
-----
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
--
P
G
-
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
-
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
K
-
I
P
E
G
-
D
-
L
-
I
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
L
-
N
-
N
-
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
-
F
---
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
--
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
E
E
A
-
A
-
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
-----------
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
--
V
-
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
-
R
N
H
P
P
--------------------------------
6
PsiBlast_PDB
85.14
72%
-93
- C1 -
-
4TND
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
--
G
G
G
K
R
K
G
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
C
----
E
D
--
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
I
G
R
L
L
F
R
Q
F
C
-
E
-
T
-
R
P
G
L
E
C
-
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
-
D
E
K
L
G
E
K
G
K
K
I
M
T
K
Y
L
-------
T
P
K
-
S
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
-
L
Q
-
K
P
C
K
-----
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
--
P
G
-
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
-
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
K
-
I
P
E
G
-
D
-
L
-
I
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
L
-
N
-
N
-
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
-
F
---
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
--
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
E
E
A
-
A
-
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
-----------
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
--
V
-
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
-
R
N
H
P
P
--------------------------------
4
PsiBlast_PDB
84.89
72%
-112
- C1 -
-
4WNK
1
GRK5_BOVIN
A:
[24-541]
-------------------------
K
G
K
S
K
K
W
K
E
I
L
K
F
P
H
I
N
Q
C
----
E
D
--
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
V
G
R
L
L
F
R
Q
F
C
-
E
-
T
-
R
P
G
L
E
S
-
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
-
D
E
K
L
G
E
K
G
K
E
I
M
T
K
Y
L
-------
T
P
K
-
S
P
V
F
I
T
Q
V
G
R
D
L
V
S
Q
T
E
E
K
L
-
L
Q
-
K
P
C
K
-----
E
L
F
S
A
C
V
Q
S
V
H
D
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
Y
F
D
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
R
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
--
P
G
-
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
K
-
I
P
E
G
-
D
-
L
-
I
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
L
-
N
-
N
-
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
-
F
---
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
--
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
E
G
A
-
A
-
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
-----------
D
P
R
A
V
Y
------------------------
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
P
I
P
W
Q
S
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
H
G
T
L
S
P
D
L
N
-
R
S
H
----------------------------------
550
HHSearch
75.16
71%
-20
- C1 -
-
4TND
1
GRK5_HUMAN
A:
[15-543]
--------------
A
R
E
G
--
G
G
G
K
R
K
G
K
S
K
K
W
K
E
I
L
K
F
P
H
I
S
Q
C
----
E
D
--
L
R
R
T
I
D
R
D
Y
C
S
L
C
D
K
---
Q
P
I
G
R
L
L
F
R
Q
F
C
-
E
-
T
-
R
P
G
L
E
C
-
Y
I
Q
F
L
D
S
V
A
E
Y
E
-
V
T
P
D
E
K
L
G
-
E
K
G
K
K
I
M
T
K
Y
L
-------
T
P
K
-
S
P
V
F
I
A
Q
V
G
Q
D
L
V
S
Q
T
E
E
K
L
-
L
Q
-
K
P
C
K
-----
E
L
F
S
A
C
A
Q
S
V
H
E
Y
L
R
G
E
P
F
H
E
Y
L
D
S
M
F
F
D
R
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
R
L
E
K
K
R
I
-
K
K
R
K
G
E
S
M
A
L
N
E
---
K
---
Q
I
L
E
K
-
V
-
N
S
Q
---
F
V
V
N
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
G
--
N
--
P
G
-
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
-
E
N
-
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
Y
G
H
I
R
I
S
D
L
G
L
---
A
-
V
-
K
-
I
P
E
G
-
D
-
L
-
I
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
L
-
N
-
N
-
Q
R
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
Q
S
P
-
F
---
R
G
R
K
E
K
V
K
R
E
E
V
D
R
R
V
L
E
T
E
E
V
--
Y
S
H
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
C
-
Q
E
E
E
A
-
A
-
E
V
K
R
H
P
F
F
R
N
M
N
F
K
R
L
E
A
G
M
L
D
P
P
F
V
P
-----------
D
P
R
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
--
V
-
K
G
V
N
L
D
H
T
D
D
D
F
Y
S
K
F
S
T
G
S
V
S
I
P
W
Q
N
E
M
I
E
T
E
C
F
K
E
L
N
V
F
G
P
N
G
T
L
P
P
D
L
N
R
N
H
P
-
P
--------------------------------
7
PsiBlast_PDB
74.54
66%
-31
- C1 -
-
4YHJ
1
GRK4_HUMAN
A:
[25-525]
--------------------------
G
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
----
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
-
D
-
T
-
K
P
T
L
K
R
-
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
-
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
-------
N
D
K
-
L
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
-
N
P
S
K
-----
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
R
I
L
E
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
--
P
G
-
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
---
A
-
T
-
E
-
I
P
E
G
-
Q
-
R
-
V
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
N
-
N
-
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
-
F
---
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
--
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
E
G
A
-
A
-
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
-----------
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
--
V
--
V
-
K
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
----------------------------------------------------
551
HHSearch
74.34
65%
-31
- C1 -
-
4YHJ
1
GRK4_HUMAN
A:
[25-525]
--------------------------
G
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
----
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
-
D
-
T
-
K
P
T
L
K
R
-
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
-
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
-------
N
D
K
-
L
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
-
N
P
S
K
-----
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
R
I
L
E
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
--
P
G
-
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
---
A
-
T
-
E
-
I
P
E
G
-
Q
-
R
-
V
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
N
-
N
-
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
-
F
---
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
--
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
E
G
A
-
A
-
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
-----------
D
P
H
A
V
Y
C
K
D
V
L
D
I
E
Q
F
S
--
V
--
V
-
K
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
----------------------------------------------------
24
Blastp_CBE
72.86
67%
-29
- C1 -
-
4YHJ
1
GRK4_HUMAN
B:
[25-527]
--------------------------
G
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
----
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
-
D
-
T
-
K
P
T
L
K
R
-
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
-
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
-------
N
D
K
-
L
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
-
N
P
S
K
-----
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
R
I
L
E
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
--
P
G
-
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
---
A
-
T
-
E
-
I
P
E
G
-
Q
-
R
-
V
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
N
-
N
-
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
-
F
---
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
--
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
E
G
A
-
A
-
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
-----------
D
P
H
A
V
Y
C
------------------
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
N
K
--------------------------------------------------
552
HHSearch
72.46
65%
-29
- C1 -
-
4YHJ
1
GRK4_HUMAN
B:
[25-527]
--------------------------
G
R
S
K
K
W
K
E
I
L
T
L
P
P
V
S
Q
C
----
S
E
--
L
R
H
S
I
E
K
D
Y
S
S
L
C
D
K
---
Q
P
I
G
R
R
L
F
R
Q
F
C
-
D
-
T
-
K
P
T
L
K
R
-
H
I
E
F
L
D
A
V
A
E
Y
E
-
V
A
D
-
D
E
D
R
S
D
C
G
L
S
I
L
D
R
F
F
-------
N
D
K
-
L
A
A
P
L
P
E
I
P
P
D
V
V
T
E
C
R
L
G
L
K
E
E
-
N
P
S
K
-----
K
A
F
E
E
C
T
R
V
A
H
N
Y
L
R
G
E
P
F
E
E
Y
Q
E
S
S
Y
F
S
Q
F
L
Q
W
K
W
L
E
R
-
Q
-
P
V
T
K
N
T
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
Q
K
K
R
I
-
K
K
R
K
G
E
A
M
A
L
N
E
---
K
---
R
I
L
E
K
-
V
-
Q
S
R
---
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
G
--
N
--
P
G
-
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
-
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
R
G
H
I
R
I
S
D
L
G
L
---
A
-
T
-
E
-
I
P
E
G
-
Q
-
R
-
V
R
G
R
-
V
----
G
T
V
G
Y
M
A
P
E
V
V
-
N
-
N
-
E
K
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
H
S
P
-
F
---
K
K
Y
K
E
K
V
K
W
E
E
V
D
Q
R
I
K
N
D
T
E
E
--
Y
S
E
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
C
-
R
G
E
G
A
-
A
-
G
V
K
Q
H
P
V
F
K
D
I
N
F
R
R
L
E
A
N
M
L
E
P
P
F
C
P
-----------
D
P
H
A
V
Y
C
------------------
G
I
Y
L
D
T
A
D
E
D
F
Y
A
R
F
A
T
G
C
V
S
I
P
W
Q
N
E
M
I
E
S
G
C
F
K
D
I
N
K
--------------------------------------------------
556
HHSearch
71.17
49%
-46
- C1 -
-
4L9I
2
GRK1_BOVIN
A:
[1-503]
--------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
---
R
-
A
-
R
A
-
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
--
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
T
K
-
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
--
T
--
V
-
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
------------------------------------------------
18
PsiBlast_PDB
70.47
48%
-47
- C1 -
-
4L9I
2
GRK1_BOVIN
A:
[2-502]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
-
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
V
Y
A
K
N
I
Q
D
V
G
A
F
S
--
T
--
V
-
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
-------------------------------------------------
35
Blastp_CBE
70.32
49%
-48
- C1 -
-
4L9I
1
GRK1_BOVIN
B:
[2-502]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
-
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
V
Y
A
------------
T
--
V
-
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
-------------------------------------------------
12
PsiBlast_PDB
70.18
47%
-41
- C1 -
-
3C50
2
GRK1_BOVIN
A:
[30-533]
--------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
-
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
V
Y
A
K
N
I
Q
D
-------
T
--
V
-
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
16
PsiBlast_PDB
69.93
47%
-45
- C1 -
-
3T8O
2
GRK1_BOVIN
A:
[30-532]
--------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
-
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
K
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
-----
I
Q
D
V
G
A
F
----------
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
------------------------------------------------
15
PsiBlast_PDB
69.48
47%
-46
- C1 -
-
3C4W
1
GRK1_BOVIN
A:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
-
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
---------
Q
D
V
G
A
F
S
--
T
--
V
-
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
9
PsiBlast_PDB
69.39
47%
-45
- C1 -
-
3C4X
1
GRK1_BOVIN
A:
[30-533]
--------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
-
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
--------
I
Q
D
V
G
A
F
S
--
T
--
V
-
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
8
PsiBlast_PDB
69.31
47%
-49
- C1 -
-
4PNI
1
GRK1_BOVIN
A:
[30-533]
--------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
-
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
V
Y
A
K
N
I
-----------------
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
11
PsiBlast_PDB
68.67
47%
-47
- C1 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
-
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
--------
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
26
Blastp_CBE
68.63
48%
-42
- C1 -
-
3C50
1
GRK1_BOVIN
B:
[30-533]
--------------------------
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
-
G
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
V
Y
--------
A
F
S
--
T
--
V
-
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
570
Fugue
68.60
48%
-49
- C1 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
---------
G
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
T
K
-
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
V
Y
A
K
N
-------
G
--
A
--
F
-
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
553
HHSearch
68.57
48%
-47
- C1 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
----
A
-
R
A
-
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
--
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
T
K
-
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
V
Y
A
K
N
----
G
A
F
S
--------
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
27
Blastp_CBE
66.82
48%
-46
- C1 -
-
3C4X
1
GRK1_BOVIN
B:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
---------------
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
-------------------------
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
13
PsiBlast_PDB
65.90
47%
-44
- C1 -
-
3C51
1
GRK1_BOVIN
A:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
-
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
-------------
S
--
T
--
V
-
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
25
Blastp_CBE
64.82
48%
-84
- C1 -
-
3C51
1
GRK1_BOVIN
B:
[31-533]
---------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
----------
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
A
----------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
--
D
I
R
Y
H
I
Y
------------
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
--
E
N
K
E
L
K
Q
R
V
---------
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
--------------------
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
31
Blastp_CBE
61.28
48%
39
- C1 -
-
3C4W
1
GRK1_BOVIN
B:
[9-533]
-----
V
V
A
N
S
A
F
I
A
A
R
G
S
FD
A
S
S
G
P
A
S
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
----
E
A
--
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
---
Q
P
I
G
K
R
L
F
Q
Q
F
L
-
R
-
T
-
H
E
Q
H
G
P
-
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
A
D
-
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
-------
E
P
Q
-
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
----
R
A
-
R
---
A
G
D
-----
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
-
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
-
K
K
R
K
G
Y
Q
G
A
M
V
E
---
K
---
K
I
L
A
K
-
V
-
H
S
R
---
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
--
E
DN
P
G
-
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
---
A
-
V
-
E
-
L
K
A
G
-
Q
-
T
K
T
K
G
Y
-
A
----
G
T
P
G
F
M
A
P
E
L
L
-
L
-
G
-
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
-
F
---
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
V
T
--
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
-
R
D
G
S
C
-
D
-
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
-----------
D
S
R
T
V
Y
A
K
N
----------
T
--
V
-
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------
44
Blastp_CBE
54.69
39%
4
- C1 -
-
3PVW
1
ARBK1_BOVIN
A:
[29-537]
-----------------------------
S
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
K
-
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
MKELLAC
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
-------
K
Q
-
V
P
-
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
------------------------
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
43
Blastp_CBE
53.31
39%
-5
- C1 -
-
5UKM
1
ARBK1_BOVIN
A:
[31-538]
--------------------------------
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
K
-
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
MKELLAC
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
-------
K
Q
-
V
P
-
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
N
A
A
D
A
F
D
--------------
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
45
Blastp_CBE
53.10
39%
-1
- C1 -
-
3PVU
1
ARBK1_BOVIN
A:
[30-537]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
K
-
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
MKELLAC
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
-------
K
Q
-
V
P
-
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
---------------------------
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
49
Blastp_CBE
51.11
39%
11
- C1 -
-
4PNK
1
ARBK1_HUMAN
A:
[30-531]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
-
E
V
N
A
---------------
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
50
Blastp_CBE
50.59
39%
12
- C1 -
-
3V5W
1
ARBK1_HUMAN
A:
[30-538]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
N
A
A
D
A
F
D
------------
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
48
Blastp_CBE
50.40
39%
12
- C1 -
-
5WG3
1
ARBK1_HUMAN
A:
[30-539]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
---
T
K
D
K
H
-
E
I
D
R
M
T
L
T
--
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
N
A
A
D
A
-------E-
D
--
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
55
Blastp_CBE
50.10
39%
18
- C1 -
-
3KRW
1
ARBK1_HUMAN
A:
[29-537]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
---
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
---------------EE
D
--
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
52
Blastp_CBE
49.88
39%
7
- C1 -
-
6C2Y
1
ARBK1_HUMAN
A:
[30-533]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
--
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
--------------------
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
47
Blastp_CBE
49.62
39%
4
- C1 -
-
5WG4
1
ARBK1_HUMAN
A:
[31-536]
--------------------------------
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
--
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
N
A
A
D
A
------------
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
557
HHSearch
49.42
38%
20
- C1 -
-
3V5W
1
ARBK1_HUMAN
A:
[30-537]
-------------------------------
K
K
I
L
L
P
E
P
S
I
R
S
V
----
M
Q
KY
L
E
D
R
G
E
V
T
F
E
K
I
F
S
----
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
N
H
-
L
E
E
A
R
P
-
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
-------
M
K
E
-
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
-
G
K
K
Q
V
P
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
IML
S
L
V
S
T
-
G
-
D
C
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
------
V
-
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
---
K
-
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
-
Q
-
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
N
A
A
D
A
F
D
------------
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
---------------------------------------------------
54
Blastp_CBE
49.21
39%
21
- C1 -
-
3KRX
1
ARBK1_HUMAN
A:
[29-537]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
---
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
---------------EE
D
--
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
560
HHSearch
48.96
39%
37
- C1 -
-
4MK0
1
ARBK1_HUMAN
A:
[3-503]
-----------------------------------
I
L
L
P
E
P
S
I
R
SVMQ
K
Y
--
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
---
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
N
H
-
L
E
E
A
R
P
-
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
-------
M
K
E
-
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
-
G
K
K
Q
V
P
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
-
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
IML
S
L
V
S
T
-
G
-
D
C
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
------
G
V
-
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
---
K
-
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
-
Q
-
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
N
A
A
D
A
F
------------T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
-------------------------------------------------
38
Blastp_CBE
48.44
41%
10
- C1 -
-
5HE3
1
ARBK1_BOVIN
A:
[32-502]
----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
K
-
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
MKELLAC
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
-------
K
Q
-
V
P
-
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
--------------------
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
561
HHSearch
47.51
39%
38
- C1 -
-
5UKL
1
ARBK1_HUMAN
A:
[3-502]
-----------------------------------
I
L
L
P
E
P
S
I
R
SVMQ
K
Y
--
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
---
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
H
L
E
E
A
R
P
-
L
V
E
F
Y
E
E
I
K
K
Y
E
-
K
L
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
-------
M
K
E
-
L
L
A
C
S
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
-
G
K
K
Q
V
P
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
IML
S
L
V
S
T
-
G
-
D
C
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
------
G
V
-
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
---
K
-
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
-
Q
-
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
N
A
A
D
A
F
D
--------------
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
T
-
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
40
Blastp_CBE
47.16
41%
11
- C1 -
-
5HE0
1
ARBK1_BOVIN
A:
[32-502]
----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
K
-
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
MKELLAC
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
-------
K
Q
-
V
P
-
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
---------------------
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
39
Blastp_CBE
46.78
41%
18
- C1 -
-
5HE2
1
ARBK1_BOVIN
A:
[32-502]
----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
K
-
H
L
E
E
A
K
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
L
V
C
S
R
E
I
F
D
T
Y
I
MKELLAC
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
-------
K
Q
-
V
P
-
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
-----------
G
S
F
D
EE
D
--
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
46
Blastp_CBE
46.55
39%
33
- C1 -
-
5WG5
1
ARBK1_HUMAN
A:
[30-535]
------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
--------
M
Q
K
Y
L
E
D
R
G
E
V
T
F
E
K
IFS
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
-PP---
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
---
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
---
V
N
A
A
D
A
F
--------
D
--
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
559
HHSearch
45.75
39%
25
- C1 -
-
5UVC
1
ARBK1_HUMAN
A:
[39-539]
-----------------------------
K
----
K
I
L
L
P
E
P
S
I
R
SVMQ
K
Y
--
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
---
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
-
H
-
L
E
E
A
R
P
-
L
V
E
F
Y
E
E
I
K
K
Y
E
-
K
L
E
-----
V
A
R
S
R
E
I
F
D
S
Y
I
-------
M
K
E
-
L
L
A
-----------------------
P
P
-----
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
-
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
RIM
L
---
S
L
V
S
T
-
G
-
D
C
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
------
G
V
-
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
---
K
-
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
-
Q
K
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
--------------------------
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
---------------------------------------------------
569
HHSearch
45.62
34%
-110
- C1 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[94-373]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
------
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
-
K
-
R
-
V
K
G
R
-----
T
W
T
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
---
F
A
D
Q
P
----
I
Q
I
Y
E
K
I
V
S
G
K
V
R
--
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------
K
F
----------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
44.77
41%
33
- C1 -
-
5UKK
1
ARBK1_HUMAN
A:
[32-502]
----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
----------
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
N
A
A
D
A
F
-------------------
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
57
Blastp_CBE
44.07
41%
35
- C1 -
-
5UKL
1
ARBK1_HUMAN
A:
[32-502]
----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
N
A
A
D
A
F
D
--------------
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
56
Blastp_CBE
43.93
41%
41
- C1 -
-
4MK0
1
ARBK1_HUMAN
A:
[32-502]
----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
N
A
A
D
A
F
-----------
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
36
Blastp_CBE
42.78
41%
25
- C1 -
-
5UVC
1
ARBK1_HUMAN
A:
[70-540]
----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
------
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
----------------------PP---
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
--------------------------
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
53
Blastp_CBE
42.58
41%
45
- C1 -
-
5HE1
1
ARBK1_HUMAN
A:
[33-506]
----------------------------------------------------------------------
Q
K
L
G
Y
L
L
F
R
D
F
C
-
L
-
N
-
H
L
E
E
A
R
P
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
E
T
-
E
E
E
R
V
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
L
A
-
C
S
H
P
F
S
K
S
A
T
E
H
V
-
Q
G
-
H
L
G
K
KQVPP
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
---------------------
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
62
Blastp_CBE
41.91
39%
-60
- C1 -
-
2X39
1
AKT2_HUMAN
A:
[7-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
-------------
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
--
T
--
A
-
Q
S
I
T
I
T
P
P
D
R
--------------------------------------------------------------------------------
65
Blastp_CBE
41.37
39%
-59
- C1 -
-
2JDO
2
AKT2_HUMAN
A:
[7-342]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
-------------
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
--
T
--
A
-
Q
S
I
T
I
T
P
P
D
R
--------------------------------------------------------------------------------
64
Blastp_CBE
41.34
39%
-59
- C1 -
-
2JDR
1
AKT2_HUMAN
A:
[7-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
-------------
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
--
T
--
A
-
Q
S
I
T
I
T
P
P
D
R
--------------------------------------------------------------------------------
37
Blastp_CBE
40.75
41%
21
- C1 -
-
5UUU
2
ARBK1_HUMAN
A:
[40-540]
--------------------------------------------------------------------------
Y
L
L
F
R
D
F
C
-
L
--------
R
P
L
V
E
F
Y
E
E
---------------
A
R
S
R
E
I
---
F
D
-------
S
Y
I
-
M
K
E
L
------------------
G
-
H
L
--------
L
F
Q
P
Y
---
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
---
I
M
L
S
L
-
V
-
S
T
G
DCP
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
---
Y
H
L
S
--
Q
--
H
G
V
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
-
K
-
P
--
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
-
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
------------E-
D
--
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
--------------------------------------------------
558
HHSearch
40.37
39%
19
- C1 -
-
5UUU
2
ARBK1_HUMAN
A:
[40-542]
----------------------------------
K
I
L
L
P
E
P
S
I
R
SVMQ
K
Y
--
L
E
D
R
G
E
V
T
F
E
K
I
-
F
S
---
Q
K
L
G
Y
L
L
F
R
D
F
C
L
N
---------------------------------------------------------------------------------------------------
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
-
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
-
K
M
K
Q
G
E
T
L
A
L
N
E
---
R
IML
S
L
V
S
T
-
G
-
D
C
P
---
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
------
G
V
-
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
-
R
F
-
V
V
Y
R
D
L
K
P
A
N
I
L
L
D
E
H
G
H
V
R
I
S
D
L
G
L
---
A
-
C
-
D
-
F
S
K
K
---
K
-
P
H
A
S
-
V
----
G
T
H
G
Y
M
A
P
E
V
L
-
Q
K
G
-
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
-
F
---
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
V
E
--
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
-
L
G
R
G
A
-
Q
-
E
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
-----------
P
R
G
E
V
---------------ED
T
-
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
E
T
------------------------------------------------
74
Blastp_CBE
38.59
39%
-23
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[5-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
K
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
-------------
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
--
T
--
A
-
Q
M
I
T
I
T
P
P
D
Q
D
-------------------------------------------------------------------------------
288
Blastp_CBE
38.36
35%
-58
- C1 -
-
2UZW
1
KAPCA_BOVIN
E:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
38.23
35%
-59
- C1 -
-
2OJF
1
KAPCA_BOVIN
E:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
38.09
39%
-12
- C1 -
-
3MVH
1
AKT1_HUMAN
A:
[7-337]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
K
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
-------------
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
--
T
--
A
-
Q
M
I
T
I
T
P
P
D
Q
D
-------------------------------------------------------------------------------
328
Blastp_CBE
37.92
35%
-61
- C1 -
-
2OH0
1
KAPCA_BOVIN
E:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
37.91
35%
-59
- C1 -
-
2F7E
1
KAPCA_BOVIN
E:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
37.74
35%
-63
- C1 -
-
2UZU
1
KAPCA_BOVIN
E:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
37.65
39%
-19
- C1 -
-
3OCB
1
AKT1_HUMAN
B:
[6-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
K
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
-------------
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
--
T
--
A
-
Q
M
I
T
I
T
P
P
D
Q
D
-------------------------------------------------------------------------------
291
Blastp_CBE
37.59
35%
-62
- C1 -
-
2UZT
1
KAPCA_BOVIN
A:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
37.52
39%
-15
- C1 -
-
4EKK
1
AKT1_HUMAN
A:
[6-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
K
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
-------------
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
--
T
--
A
-
Q
M
I
T
I
T
P
P
D
Q
D
-------------------------------------------------------------------------------
329
Blastp_CBE
37.51
35%
-64
- C1 -
-
2F7Z
1
KAPCA_BOVIN
E:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
37.45
35%
-56
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[27-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
37.43
39%
-15
- C1 -
-
3QKL
1
AKT1_HUMAN
A:
[6-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
K
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
-------------
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
--
T
--
A
-
Q
M
I
T
I
T
P
P
D
Q
D
-------------------------------------------------------------------------------
78
Blastp_CBE
37.36
39%
-18
- C1 -
-
4EKK
1
AKT1_HUMAN
B:
[6-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
K
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
-------------
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
--
T
--
A
-
Q
M
I
T
I
T
P
P
D
Q
D
-------------------------------------------------------------------------------
92
Blastp_CBE
37.34
39%
-14
- C1 -
-
3CQU
1
AKT1_HUMAN
A:
[7-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
K
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
-------------
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
--
T
--
A
-
Q
M
I
T
I
T
P
P
D
Q
D
-------------------------------------------------------------------------------
86
Blastp_CBE
37.14
39%
-14
- C1 -
-
3OCB
1
AKT1_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
K
D
G
-
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
-------------
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
--
T
--
A
-
Q
M
I
T
I
T
P
P
D
Q
D
-------------------------------------------------------------------------------
148
Blastp_CBE
36.11
37%
-36
- C1 -
-
5F9E
1
KPCT_HUMAN
A:
[21-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
S
L
-
A
-
W
E
H
P--
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
-----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
-
K
-
E
-
N
M
L
G
-
D
-
A
-
K
T
N
E
-
F
C---
G
T
P
D
Y
I
A
P
E
I
L
-
L
-
G
-
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
-
F
---
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
--
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
------
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
35.93
37%
-39
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[7-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
S
L
-
A
-
W
E
H
P--
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
-----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
-
K
-
E
-
N
M
L
G
-
D
-
A
-
K
T
N
E
-
F
C---
G
T
P
D
Y
I
A
P
E
I
L
-
L
-
G
-
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
-
F
---
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
--
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
------
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----------------------------------------------------------------------------------------------------------------------------
562
HHSearch
35.82
39%
-23
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
-
V
A
K
D
E
V
A
H
T
L
T
E
---
N
---
R
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
------
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
-
G
I
K
D
G
A
-
T
-
M
K
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
----
K
L
F
E
L
I
L
M
E
E
I
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----------
Q
V
----------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
35.63
34%
-61
- C1 -
-
5LCU
5
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
35.50
34%
-60
- C1 -
-
5N3J
4
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
35.43
34%
-61
- C1 -
-
5M71
2
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
35.42
34%
-61
- C1 -
-
5M75
2
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
35.37
37%
-34
- C1 -
-
4Q9Z
1
KPCT_HUMAN
A:
[7-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
S
L
-
A
-
W
E
H
P--
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
-----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
-
K
-
E
-
N
M
L
G
-
D
-
A
-
K
T
N
E
-
F
C---
G
T
P
D
Y
I
A
P
E
I
L
-
L
-
G
-
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
-
F
---
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
--
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
------
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
-----------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
35.32
34%
-62
- C1 -
-
5OUC
2
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
35.20
35%
-69
- C1 -
-
3RWP
5
PDPK1_HUMAN
A:
[34-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
-----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
-----------
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
35.14
34%
-61
- C1 -
-
5NW8
2
KAPCA_CRIGR
A:
[30-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
35.13
41%
-53
- C1 -
-
3E87
1
AKT2_HUMAN
B:
[2-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
35.09
35%
-70
- C1 -
-
2PE2
9
PDPK1_HUMAN
A:
[9-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
------
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
------------F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
35.01
34%
-60
- C1 -
-
5O0E
2
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
35.00
34%
-60
- C1 -
-
5N1F
3
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
34.99
34%
-60
- C1 -
-
5LCT
4
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
34.98
34%
-61
- C1 -
-
5N1D
3
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
---
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
34.98
39%
-45
- C1 -
-
1O6K
1
AKT2_HUMAN
A:
[2-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
-------------
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
--
T
--
A
-
Q
S
I
T
I
T
P
P
D
R
--------------------------------------------------------------------------------
272
Blastp_CBE
34.93
34%
-61
- C1 -
-
4NTT
1
KAPCA_MOUSE
A:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
34.92
35%
-73
- C1 -
-
2PE0
4
PDPK1_HUMAN
A:
[9-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
------
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
------------F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
34.85
35%
-65
- C1 -
-
2GNL
1
KAPCA_BOVIN
A:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
34.72
35%
-63
- C1 -
-
1Q8W
1
KAPCA_BOVIN
A:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
34.68
33%
-58
- C1 -
-
1L3R
3
KAPCA_MOUSE
E:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
34.69
34%
-61
- C1 -
-
3IDC
1
KAPCA_MOUSE
A:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
34.68
34%
-61
- C1 -
-
6I2A
1
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
34.67
34%
-59
- C1 -
-
5N3G
4
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
34.63
41%
-53
- C1 -
-
3E87
1
AKT2_HUMAN
A:
[2-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
34.61
34%
-60
- C1 -
-
5NTJ
2
KAPCA_CRIGR
A:
[32-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
34.61
34%
-58
- C1 -
-
2ERZ
1
KAPCA_MOUSE
E:
[30-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
34.60
41%
-51
- C1 -
-
3D0E
1
AKT2_HUMAN
B:
[2-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
34.58
34%
-57
- C1 -
-
5N3O
6
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
34.56
34%
-59
- C1 -
-
5N3L
4
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
34.55
39%
-43
- C1 -
-
1O6L
1
AKT2_HUMAN
A:
[2-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
-------------
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
--
T
--
A
-
Q
S
I
T
I
T
P
P
D
R
--------------------------------------------------------------------------------
325
Blastp_CBE
34.54
35%
-61
- C1 -
-
1Q8U
3
KAPCA_BOVIN
A:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
34.51
35%
-59
- C1 -
-
1YDR
1
KAPCA_BOVIN
E:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
34.51
34%
-58
- C1 -
-
5LCP
4
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
34.51
41%
-51
- C1 -
-
3D0E
1
AKT2_HUMAN
A:
[2-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
34.50
34%
-61
- C1 -
-
6EMB
1
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
34.47
33%
-59
- C1 -
-
4DG0
2
KAPCA_MOUSE
E:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
34.44
35%
-67
- C1 -
-
3SC1
3
PDPK1_HUMAN
A:
[34-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
-----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
----------
A
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
34.42
34%
-55
- C1 -
-
3OW3
1
KAPCA_MOUSE
A:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
34.41
34%
-59
- C1 -
-
5OK3
1
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
34.41
34%
-58
- C1 -
-
5M6V
1
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
34.41
41%
-50
- C1 -
-
3E8D
1
AKT2_HUMAN
A:
[2-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
34.40
34%
-56
- C1 -
-
4HPT
1
KAPCA_MOUSE
E:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
34.38
33%
-56
- C1 -
-
4IB3
1
KAPCA_MOUSE
A:
[35-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
34.36
33%
-56
- C1 -
-
4IAY
1
KAPCA_MOUSE
A:
[35-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
34.34
34%
-54
- C1 -
-
1JBP
2
KAPCA_MOUSE
E:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
---------
F
A
D
E
P
I
Q
I
Y
E
K
I
V
S
G
K
VR
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
34.31
34%
-58
- C1 -
-
6EM7
4
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
34.31
34%
-56
- C1 -
-
6ESA
4
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
34.28
35%
-61
- C1 -
-
2GNH
2
KAPCA_BOVIN
A:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
34.26
33%
-57
- C1 -
-
3X2V
1
KAPCA_MOUSE
A:
[36-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
34.21
33%
-61
- C1 -
-
4IAK
1
KAPCA_MOUSE
A:
[35-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
34.19
33%
-54
- C1 -
-
4IAI
2
KAPCA_MOUSE
A:
[35-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
34.18
37%
-45
- C1 -
-
3TXO
1
A:
[23-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
-----
T
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
-
L
Q
D
D
D
V
E
C
T
M
T
E
---
K
---
R
I
L
S
L
-
A
R
N
H
P
---
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
--
R
-----
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
---
C
-
K
-
E
G
I
-------------
C
----
G
T
P
D
Y
I
A
P
E
I
L
-
Q
-
E
-
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
-
F
---
E
A
E
N
E
D
D
L
F
E
A
I
--
L
N
D
E
V
V
----
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
G
G
E
-
H
-
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
RIKSREDVSNF
D
P
D
F
I
K
E
E
P
V
L
P
I
D
E
---------------------------------------------------------------------------------------------------
411
Blastp_CBE
34.15
34%
-54
- C1 -
-
5N1L
4
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
---
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
34.15
34%
-61
- C1 -
-
6ERW
2
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
---
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
34.15
41%
-52
- C1 -
-
3E88
1
AKT2_HUMAN
A:
[2-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
34.13
38%
-6
- C1 -
-
4RA4
1
KPCA_HUMAN
A:
[15-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
V
-
K
L
T
D
F
N
F
L
M
--
V
L
G
K
G
S
F
G
K
V
M
L
A
D
R
K
G
-----
T
E
----
E
L
Y
A
I
K
I
L
K
K
D
V
V
-
I
Q
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
A
L
-
L
-
D
K
P
P--
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
G
--
K
-----
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
---
C
-
K
E
H
-
M
M
D
G
-
V
-
T
-
T
R
T
F
-
C
----
G
T
P
D
Y
I
A
P
E
I
I
-
A
-
Y
-
Q
P
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
P
P
-
F
---
D
G
E
D
E
----
D
E
L
F
Q
S
I
M
E
H
N
V
S
--
Y
P
K
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
L
G
C
-
G
P
E
G
E
-
R
-
D
V
R
E
H
A
F
F
R
R
I
D
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
--------------
K
V
S
G
K
G
A
E
N
F
D
K
F
F
--
T
----
R
G
Q
P
V
L
P
P
D
Q
--------------------------------------------------------------------------------
450
Blastp_CBE
34.12
33%
-55
- C1 -
-
4IB0
1
KAPCA_MOUSE
A:
[35-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
34.11
34%
-60
- C1 -
-
2QUR
1
KAPCA_MOUSE
A:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
P
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
34.11
34%
-58
- C1 -
-
6C0U
4
KAPCA_HUMAN
A:
[33-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
A
Q
-
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
34.09
41%
-51
- C1 -
-
3E8D
1
AKT2_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
34.07
35%
-68
- C1 -
-
2PE1
5
PDPK1_HUMAN
A:
[9-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
------
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
------------F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
34.06
33%
-57
- C1 -
-
4IAD
1
KAPCA_MOUSE
A:
[35-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
34.02
33%
-58
- C1 -
-
4HPU
2
KAPCA_MOUSE
E:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
33.97
35%
-66
- C1 -
-
1UU8
7
PDPK1_HUMAN
A:
[32-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
-----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
----------
A
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
33.97
33%
-58
- C1 -
-
4XW6
1
KAPCA_MOUSE
A:
[35-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
33.97
34%
-55
- C1 -
-
5LCR
6
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
33.93
33%
-55
- C1 -
-
4DH5
1
KAPCA_MOUSE
A:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
33.88
33%
-55
- C1 -
-
1RDQ
3
KAPCA_MOUSE
E:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
A
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
33.85
35%
-71
- C1 -
-
3IOP
1
PDPK1_HUMAN
A:
[35-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
-----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
-----------
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
33.83
41%
-52
- C1 -
-
3E88
1
AKT2_HUMAN
B:
[2-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
-
I
A
K
D
E
V
A
H
T
V
T
E
---
S
---
R
V
L
Q
N
-
T
-
R
H
P
---
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G
I
S
D
G
-
A
-
T
-
M
K
F
--
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
R
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
P
S
D
A
-
K
-
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
33.80
34%
-60
- C1 -
-
6EMA
2
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
33.80
34%
-54
- C1 -
-
2GU8
1
KAPCA_HUMAN
A:
[16-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
E
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
33.76
34%
-55
- C1 -
-
5M6Y
2
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
33.73
33%
-56
- C1 -
-
3X2W
1
KAPCA_MOUSE
A:
[36-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
33.72
34%
-56
- C1 -
-
5M0U
10
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
----
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
33.64
34%
-54
- C1 -
-
5N3A
4
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
33.64
35%
-58
- C1 -
-
1Q8T
1
KAPCA_BOVIN
A:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
33.58
33%
-54
- C1 -
-
2QCS
5
KAPCA_MOUSE
A:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
33.56
33%
-54
- C1 -
-
4IB1
1
KAPCA_MOUSE
A:
[35-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
33.56
35%
-59
- C1 -
-
2GNI
1
KAPCA_BOVIN
A:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
33.53
35%
-62
- C1 -
-
2XCH
6
PDPK1_HUMAN
A:
[32-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
-----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
----------
A
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
33.53
35%
-63
- C1 -
-
3ZO2
4
KAPCA_BOVIN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
33.51
35%
-59
- C1 -
-
3ZO4
4
KAPCA_BOVIN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
33.51
35%
-61
- C1 -
-
2GNF
1
KAPCA_BOVIN
A:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
33.49
35%
-59
- C1 -
-
3OVV
2
KAPCA_HUMAN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
33.42
34%
-57
- C1 -
-
5OT3
3
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
33.36
34%
-62
- C1 -
-
5N3F
3
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
-----
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
--
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
-
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
33.36
35%
-59
- C1 -
-
4UJ2
2
KAPCA_HUMAN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
33.35
35%
-56
- C1 -
-
2JDS
1
KAPCA_BOVIN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
33.28
35%
-59
- C1 -
-
2C1B
1
KAPCA_BOVIN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
33.25
35%
-60
- C1 -
-
1STC
1
KAPCA_BOVIN
E:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
33.23
33%
-54
- C1 -
-
4DFX
5
KAPCA_MOUSE
E:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
33.19
35%
-58
- C1 -
-
4YXS
1
KAPCA_BOVIN
A:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
D
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
33.16
34%
-57
- C1 -
-
6ERS
1
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
--
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
33.11
34%
-62
- C1 -
-
4C37
2
KAPCA_BOVIN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
33.09
34%
-57
- C1 -
-
6I2C
1
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
S
Q
-
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
--
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
33.07
35%
-58
- C1 -
-
3NX8
3
KAPCA_HUMAN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
-
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
33.07
33%
-50
- C1 -
-
4XW4
1
KAPCA_MOUSE
A:
[35-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
33.07
35%
-59
- C1 -
-
4IE9
2
KAPCA_BOVIN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
33.02
35%
-56
- C1 -
-
3OWP
1
KAPCA_HUMAN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
32.96
35%
-59
- C1 -
-
3L9L
1
KAPCA_HUMAN
B:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
32.93
35%
-62
- C1 -
-
1UU9
8
PDPK1_HUMAN
A:
[11-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
------
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
-----------
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
32.88
35%
-62
- C1 -
-
3ZO1
7
KAPCA_BOVIN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
32.87
35%
-60
- C1 -
-
4UJ1
2
KAPCA_HUMAN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
32.82
35%
-61
- C1 -
-
4WB5
1
KAPCA_HUMAN
A:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
32.67
35%
-59
- C1 -
-
1SMH
6
KAPCA_BOVIN
A:
[41-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
E
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
L
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
32.47
34%
-50
- C1 -
-
4DIN
1
KAPCA_MOUSE
A:
[29-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
T
P
S
Q
-
N
-
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
S
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
32.46
35%
-56
- C1 -
-
3OXT
1
KAPCA_HUMAN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
32.45
34%
-61
- C1 -
-
4C36
1
KAPCA_BOVIN
A:
[42-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
H
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
32.32
34%
-52
- C1 -
-
5N1K
3
KAPCA_CRIGR
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
S
P
---
N
-
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
------
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
K
L
K
Q
I
E
H
T
L
N
E
---
K
---
R
I
L
Q
A
-
V
-
N
F
P
---
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
-
E
P
H
A
R
--
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
---
A
----------
K
-
R
-
V
K
G
R
-
T
WLC-
G
T
P
E
Y
L
A
P
E
I
I
-
L
-
S
-
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
-------
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
-
L
K
N
G
V
-
N
-
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
31.92
40%
-56
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[117-441]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
------------------------
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
--------------------------
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
31.23
40%
-59
- C1 -
-
6HHF
1
AKT1_HUMAN
A:
[111-427]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--------------------------
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-----------------------
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
30.95
35%
-68
- C1 -
-
1UVR
8
PDPK1_HUMAN
A:
[12-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
------
S
-
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
P
-------
A
R
A
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
30.26
38%
-30
- C1 -
-
3PFQ
1
KPCB_RAT
A:
[343-620]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
R
K
G
-----
T
D
----
E
L
Y
A
V
K
I
L
K
K
D
V
V
-
I
Q
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
A
L
-
P
-
G
K
P
P--
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
G
--
R
-----
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
---
C
-
K
E
N
-
I
W
D
G
-
V
-
T
-
T
K
-
F
-
C
----
G
T
P
D
Y
I
A
P
E
I
I
-
A
-
Y
-
Q
P
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
-
F
---
E
G
E
D
E
----
D
E
L
F
Q
S
I
M
E
H
N
V
A
--
Y
P
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
C
-
G
P
E
G
E
-
R
-
D
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
-----------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
30.22
34%
-32
- C1 -
-
5LI9
13
KPCI_HUMAN
A:
[8-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
K
-----
T
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
-
N
D
D
E
D
I
D
W
V
Q
T
E
---
K
---
H
V
F
E
Q
-
A
S
N
H
P
---
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
----
Q
--
R
K
-
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
-
K
-
E
-
G
L
R
P
-
G
-
D
-
T
T
S
F
-
C
----
G
T
P
N
Y
I
A
P
E
I
L
-
R
-
G
-
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
-
F
D----------
E
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
--
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
-
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----------
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
---
T
--
N
-
E
P
V
Q
L
-
P
D
D
D
D
I
V
R
K
---------------------------------------------------------------------------
534
Blastp_CBE
30.06
35%
-62
- C1 -
-
3RWQ
4
PDPK1_HUMAN
A:
[34-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
E
L
A
-----
T
S
----
R
E
Y
A
I
K
I
L
E
K
R
H
I
-
I
K
E
N
K
V
P
Y
V
T
R
E
---
R
---
D
V
M
S
R
-
L
-
D
H
P
---
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
G
--
S
-----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
---
A
K
V
-
L
-
S
P
-------
A
R
A
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
-
T
-
E
-
K
S
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
-
F
---
R
A
G
N
E
Y
L
I
F
Q
K
I
I
K
L
E
Y
D
F
P
------
E
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
-
E
E
M
E
G
-
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
30.04
37%
9
- C1 -
-
4OTG
1
A:
[4-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
-
S
-
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
F
R
P
-----
S
G
----
E
L
F
A
I
K
A
L
K
K
G
D
I
-
V
A
R
D
E
V
E
S
L
M
C
E
---
K
---
R
I
L
A
A
-
V
-
T
S
A
GHP
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
-----
S
--
D
V
-
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
-
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
---
C
------
K
E
G
-
M
-
G
-
Y
G
D
R
-
T
SFC-
G
T
P
E
F
L
A
P
E
V
L
-
T
-
D
-
T
S
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
-
F
---
P
G
D
D
E
----
E
E
V
F
D
S
I
V
N
D
E
V
R
--
Y
P
R
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
-
S
E
R
D
A
-
E
-
D
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
-----------
T
L
S
----------------
T
--
G
-
E
A
P
T
L
P
P
R
D
---------------------------------------------------------------------------------
131
Blastp_CBE
29.91
34%
-37
- C1 -
-
1XJD
1
A:
[19-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
-----
T
N
----
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
D
D
V
E
C
T
M
V
E
---
K
---
R
V
L
S
L
-
A
-
W
E
H
P--
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
H
--
K
-----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
---
C
-
K
-
E
-
N
M
L
G
-
D
-
A
-
K
T
N
F
-
C
----
G
T
P
D
Y
I
A
P
E
I
L
-
L
-
G
-
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
-
F
---
H
G
Q
D
E
----
E
E
L
F
H
S
I
R
M
D
N
P
F
--
Y
P
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
-
R
G
------
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
------------------------------------------------
N
M
F
R
N
F
--------------------------------------------------------------------------
161
Blastp_CBE
28.82
40%
-31
- C1 -
-
2R5T
1
SGK1_HUMAN
A:
[40-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-------------------
V
L
L
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
--
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C--
K
-
E
-
N
-
I
E
H
N
-
S
-
T
-
T
S
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
H
-
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
-
F
---
Y
S
R
N
T
A
----
E
M
Y
D
N
I
L
N
K
P
L
Q
--
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
-
D
D
F
-
M
-
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----------
N
-----------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
28.76
40%
-34
- C1 -
-
3HDN
1
SGK1_HUMAN
A:
[40-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-------------------
V
L
L
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
--
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C--
K
-
E
-
N
-
I
E
H
N
-
S
-
T
-
T
S
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
H
-
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
-
F
---
Y
S
R
N
T
A
----
E
M
Y
D
N
I
L
N
K
P
L
Q
--
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
-
D
D
F
-
M
-
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
28.69
34%
-29
- C1 -
-
5LIH
3
KPCI_HUMAN
A:
[7-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
K
-----
T
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
--------
W
V
Q
T
E
---
K
---
H
V
F
E
Q
-
A
S
N
H
P
---
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
----
Q
--
R
K
-
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
-
K
-
E
-
G
L
R
P
-
G
-
D
-
T
T
S
F
-
C
----
G
T
P
N
Y
I
A
P
E
I
L
-
R
-
G
-
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
-
F
DIV------
N
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
--
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
-
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----------
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
---
T
--
N
-
E
P
V
Q
L
-
P
D
D
D
D
I
V
R
K
---------------------------------------------------------------------------
160
Blastp_CBE
28.17
40%
-29
- C1 -
-
3HDM
1
SGK1_HUMAN
A:
[40-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-------------------
V
L
L
K
N
V
-
K
H
P
---
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
--
R
C
-
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C--
K
-
E
-
N
-
I
E
H
N
-
S
-
T
-
T
S
T
F
-
C
----
G
T
P
E
Y
L
A
P
E
V
L
-
H
-
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
-
F
---
Y
S
R
N
T
A
----
E
M
Y
D
N
I
L
N
K
P
L
Q
--
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
-
K
-
D
D
F
-
M
-
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----------
N
-----------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
27.79
40%
-25
- C1 -
-
6HHH
1
AKT1_HUMAN
A:
[111-427]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
H
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
---------------------
R
V
L
Q
N
-
S
-
R
H
P
---
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
--
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
---
C
-
K
-
E
G-------------------
G
T
P
E
Y
L
A
P
E
V
L
-
E
-
D
-
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
---
Y
N
Q
D
H
E
K
L
F
E
L
I
--
L
M
E
E
I
--
R
--
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-
G
S
E
D
A
-
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
27.76
34%
-31
- C1 -
-
6ILZ
1
KPCI_HUMAN
E:
[12-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
--------
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
V
-
N
D
D
E
D
I
D
W
V
Q
T
E
---
K
---
H
V
F
E
Q
-
A
S
N
H
P
---
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
----
Q
--
R
K
-
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
-
K
-
E
-
G
L
R
P
-
G
-
D
-
T
T
S
F
-
C
----
G
T
P
N
Y
I
A
P
E
I
L
-
R
-
G
-
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
-
F
DI----------
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
--
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
-
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----------
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
---
T
-----
P
V
Q
L
-
P
D
D
D
D
I
V
R
K
---------------------------------------------------------------------------
113
Blastp_CBE
27.75
39%
4
- C1 -
-
3WE4
1
KS6B1_HUMAN
A:
[21-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
-
K
-
E
-
S
I
H
D
-----
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
---------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
27.70
34%
-31
- C1 -
-
5LIH
3
KPCI_HUMAN
B:
[7-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
K
-----
T
D
----
R
I
Y
A
M
K
V
V
K
K
E
L
----------
V
Q
T
E
---
K
---
H
V
F
E
Q
-
A
S
N
H
P
---
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
----
Q
--
R
K
-
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
---
C
-
K
-
E
-
G
L
R
P
-
G
-
D
-
T
T
S
F
-
C
----
G
T
P
N
Y
I
A
P
E
I
L
-
R
-
G
-
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
-
F
DI---------
E
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
--
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
-
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-----------
N
I
S
G
E
F
G
L
D
N
F
D
-
S
Q
F
---
T
--
N
-
E
P
V
Q
L
-
P
D
D
D
D
I
V
R
K
---------------------------------------------------------------------------
118
Blastp_CBE
27.32
39%
9
- C1 -
-
4L45
1
KS6B1_HUMAN
A:
[20-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
CKE
S
------------------------
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
S
--------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
27.19
39%
8
- C1 -
-
4L3J
1
KS6B1_HUMAN
A:
[20-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
CKE
S
-
I
-
H
---
D
G
-
T
-
V
-
T
H
T
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
S
--------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
27.05
39%
10
- C1 -
-
4L43
1
KS6B1_HUMAN
A:
[20-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
CKE
S
------------------------
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
S
--------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
26.83
39%
9
- C1 -
-
3WF7
2
KS6B1_HUMAN
A:
[21-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
-
K
-
E
-
S
I
H
D
-----
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
---------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
26.82
38%
-12
- C1 -
-
6G78
1
KS6A6_HUMAN
B:
[31-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------------
D
I
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
--
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
S
V
------------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
----
D
R
N
E
T
M
N
M
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
G
--
V
-
E
-
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
26.77
39%
10
- C1 -
-
4L44
1
KS6B1_HUMAN
A:
[20-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
CKE
S
-
I
-
H
-----------
H
T
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
S
--------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
26.55
38%
5
- C1 -
-
6G77
2
KS6A6_HUMAN
B:
[31-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------------
D
I
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
--
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
S
V
D
Q
E
-
K
-
K
-
A
Y
S
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
----
D
R
N
E
T
M
N
M
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
G
--
V
-
E
-
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
26.45
38%
-8
- C1 -
-
6G78
1
KS6A6_HUMAN
A:
[31-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------------
D
I
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
--
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
S
V
D
Q
----------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
----
D
R
N
E
T
M
N
M
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
G
--
V
-
E
-
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
26.40
39%
8
- C1 -
-
4L46
1
KS6B1_HUMAN
A:
[20-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
CKE
S
-
I
-
H
---
D
-------
H
T
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
S
--------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
26.31
39%
15
- C1 -
-
4L3L
1
KS6B1_HUMAN
A:
[20-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
CKE
S
-
I
-
H
---
D
G
-
T
-
V
-
T
H
T
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
S
--------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
26.15
39%
18
- C1 -
-
4L42
1
KS6B1_HUMAN
A:
[20-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
CKE
S
-
I
-
H
---
D
G
-
T
-
V
-
T
H
T
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
S
--------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
25.74
38%
3
- C1 -
-
6G77
2
KS6A6_HUMAN
A:
[31-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------------
D
I
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
--
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
S
V
D
Q
E
-
K
-
K
-
A
Y
S
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
----
D
R
N
E
T
M
N
M
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
G
--
V
-
E
-
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
25.58
38%
14
- C1 -
-
5D9L
2
KS6A3_HUMAN
A:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
-
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
R
T
K
M
-
E
---
R
---
D
I
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
G
V
-
E
-
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
25.02
38%
-5
- C1 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
--------------------------
I
L
A
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
--
S
K
--
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
---
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
D
G
A
-
E
-
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
24.69
38%
-1
- C1 -
-
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
-------------------------
I
L
A
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
--
S
K
--
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
---
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
D
G
A
-
E
-
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
24.25
38%
10
- C1 -
-
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
------------------
I
L
A
D
-
V
-
N
H
P
---
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
--
S
K
--
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
--------------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
---
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
-
G
P
D
G
A
-
E
-
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
24.14
39%
6
- C1 -
-
3A62
1
KS6B1_HUMAN
A:
[19-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
--------------
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
-
K
-
E
-------------
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
-----------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
23.36
38%
11
- C1 -
-
3G51
1
KS6A3_MOUSE
A:
[26-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
-
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-------------
R
---
D
I
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
S
I
-------------------
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
G
V
-
E
-
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
22.93
38%
-7
- C1 -
-
6G76
2
KS6A6_HUMAN
A:
[31-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
R
D
---------------
D
I
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
--
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
-
S
V
D
Q
-
E
-
K
-
K
A
Y
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
----
D
R
N
E
T
M
N
M
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
G
--
V
-
E
-
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
22.84
39%
6
- C1 -
-
3A61
1
KS6B1_HUMAN
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
---------------
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
-----------------------------
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
22.83
37%
18
- C1 -
-
3UBD
1
KS6A3_MOUSE
A:
[24-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
-
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
-------------
D
I
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
-
K
------
E
-
K
-
K
-
A
Y
S
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
G
V
-
E
-
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
22.69
39%
17
- C1 -
-
3WF8
2
KS6B1_HUMAN
A:
[21-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
-
K
-
E
-
S
I
H
D
-
G
-
T
-
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
----------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
22.41
38%
-2
- C1 -
-
6G76
1
KS6A6_HUMAN
B:
[31-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
K
T
GPD--
A
G
----
Q
L
Y
A
M
K
V
L
K
K
A
S
L
-
K
V
-------------
R
---
D
I
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
----
E
--
V
L
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
-
S
V
D
------------------
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
----
D
R
N
E
T
--------
L
G
--
M
P
Q
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
-
E
G
--
V
-
E
-
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
22.17
39%
3
- C1 -
-
3A60
1
KS6B1_HUMAN
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
-----------
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
CKE--------------------------
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
21.93
39%
17
- C1 -
-
3WF9
2
KS6B1_HUMAN
A:
[21-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
-
K
-
E
-
S
I
H
D
-
G
-
T
-
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
----------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
21.51
37%
17
- C1 -
-
4GUE
1
KS6A3_MOUSE
A:
[25-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
-
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
---------------
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
-
K
------
E
-
K
-
K
-
A
Y
S
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
G
V
-
E
-
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
21.31
39%
8
- C1 -
-
3WF5
1
KS6B1_HUMAN
A:
[21-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
-
K
-
E
-
S
I
H
D
-
G
-
T
-
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
S
--------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
21.28
37%
27
- C1 -
-
4EL9
1
KS6A3_MOUSE
A:
[25-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
-
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
R
D
R
V
---------
R
---
D
I
L
V
E
-
V
-
N
H
P
---
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
--
V
M
-
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
---
S
-
K
-
E
S---
E
-
K
-
K
-
A
Y
S
F
-
C
----
G
T
V
E
Y
M
A
P
E
V
V
-
N
-
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
---
Q
G
K
D
R
K
----
E
T
M
T
M
I
L
K
A
K
L
G
--
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
-
G
P
D
G
V
-
E
-
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
20.82
39%
9
- C1 -
-
3WF6
1
KS6B1_HUMAN
A:
[21-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
---
R
---
N
I
L
E
E
-
V
-
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
---
C
-
K
-
E
-
S
I
H
D
-
G
-
T
-
V
T
H
F
-
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
L
Q
S
--------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
19.70
39%
-2
- C1 -
-
3A60
1
KS6B1_HUMAN
B:
[19-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
-------------------------------
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
CKE
S
-------------------
C
----
G
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------
L
-----------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
19.16
40%
0
- C1 -
-
4RLO
4
KS6B1_HUMAN
B:
[7-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
-------------------------------
K
H
P
---
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
-----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
CKE
S
-
I
-----------------------
T
I
E
Y
M
A
P
E
I
L
-
M
-
R
-
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
---
T
G
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
--
L
T
Q
----
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
-
G
P
G
D
A
-
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------------------------------------------------------------------