@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GSK3B_HUMAN: (2021-11-22 )
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Atome Classification :
(466 SA)
.........10........20........30........40........50....------------....60........70.......-.80......--..90-------.------....------.---...100.......110.......120........130.......140.......150.......160.......170.......180.......190.......200......-.210-----.-------...---...220.......230.......240.......250.......260.......270.....-..--280--.......-..290--.---.......300.......310-.........320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSGRPRT
T
S
F
A
E
SCKPVQQPSAFGS
M
K
VSRDKDG
S
K
V
T
T
V
V
ATPGQGPDRPQEVS------------YTD
T
K
V
IGNGS
F
G
V
V
Y
Q
A
KLCDS-G
E
L
V
A
I
K
K
V
--
L
Q
D--------K------RFK
N
------
R
---
E
L
Q
I
M
R
K
LDHC
N
I
V
R
L
R
Y
F
F
YSSG-EKK
D
E
V
Y
L
N
L
V
L
D
YV
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
QT
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
FGICHRDIKPQ
N
L
L
LDPD
T
A
V
L
K
LCDFG
S
A
K
Q
L
V-RGEP-----
N
-------
V
S
Y
---
I
C
S
R
Y
YRA
P
E
L
I
F
GATDYTSSID
V
W
S
A
G
C
V
L
A
E
L
L
LGQPIFPGD
S
G
V
D
Q
L
V
E
I
I
K
V
LGTP
T
-
R
E
--
Q
----
I
R
EMNPN-YTEF---K---FPQIKAHPWTKVFRPRT
P
---
P
E
A
I
A
L
C
S
R
L
L
E
YTPTARL
T
P
L
E
A
C
A
H
S
F
F
D
E
LRDPNVKLPNGRDT
P
A
L
F
N
F
T
T
Q
E
LSSNP
P
L
A
T
I
L
IPPH
A
R
I
Q
AAASTPTNATAASDANTGDRGQTNNAASASASNST
85
Blastp_CBE
95.91
100%
-124
- C1 -
-
4NM0
7
GSK3B_HUMAN
A:
[26-383]
-------------------------
M
K
V
S
R
D
---
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
33
Blastp_CBE
95.32
100%
-121
- C1 -
-
1J1C
1
GSK3B_HUMAN
B:
[23-386]
----------------------
F
G
S
M
K
V
S
R
D
K
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
129
Blastp_CBE
94.94
99%
-128
- C1 -
-
1O9U
1
GSK3B_HUMAN
A:
[1-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
G
--------
K
------
A
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
A
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
A
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
72
Blastp_CBE
94.85
100%
-119
- C1 -
-
3I4B
1
GSK3B_HUMAN
A:
[19-379]
------------------------
S
M
K
V
S
R
--
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
34
Blastp_CBE
94.84
100%
-119
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[23-386]
----------------------
F
G
S
M
K
V
S
R
D
K
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
89
Blastp_CBE
94.74
100%
-123
- C1 -
-
4NM5
5
GSK3B_HUMAN
A:
[12-371]
-----------------------
G
S
M
K
V
S
R
D
K
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
116
Blastp_CBE
94.63
99%
-128
- C1 -
-
1H8F
2
GSK3B_HUMAN
A:
[1-352]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
G
--------
K
------
A
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
A
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
11
PsiBlast_PDB
94.59
100%
-125
- C1 -
-
1J1C
1
GSK3B_HUMAN
A:
[35-388]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
--------------------------------
111
Blastp_CBE
94.31
100%
-125
- C1 -
-
3SD0
2
GSK3B_HUMAN
B:
[1-349]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
115
Blastp_CBE
94.20
99%
-130
- C1 -
-
1H8F
2
GSK3B_HUMAN
B:
[1-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
G
--------
K
------
A
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
A
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
49
Blastp_CBE
94.04
99%
-124
- C1 -
-
3SAY
3
GSK3B_HUMAN
B:
[35-382]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
553
HHSearch
93.90
100%
-125
- C1 -
-
1J1B
1
GSK3B_HUMAN
A:
[35-388]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
--------------------------------
59
Blastp_CBE
93.92
99%
-126
- C1 -
-
4J71
1
GSK3B_HUMAN
B:
[40-387]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
10
PsiBlast_PDB
93.90
100%
-125
- C1 -
-
1J1B
1
GSK3B_HUMAN
A:
[35-388]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
--------------------------------
1
PsiBlast_PDB
93.83
100%
-124
- C1 -
-
4ACC
3
GSK3B_HUMAN
A:
[80-429]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
110
Blastp_CBE
93.81
100%
-121
- C1 -
-
4B7T
1
GSK3B_HUMAN
A:
[1-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
15
PsiBlast_PDB
93.78
100%
-123
- C1 -
-
6H0U
4
GSK3B_HUMAN
A:
[36-383]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
4
PsiBlast_PDB
93.73
100%
-124
- C1 -
-
4ACH
1
GSK3B_HUMAN
A:
[80-429]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
113
Blastp_CBE
93.71
99%
-125
- C1 -
-
2OW3
1
GSK3B_HUMAN
B:
[1-352]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
28
Blastp_CBE
93.70
100%
-127
- C1 -
-
4ACC
2
GSK3B_HUMAN
B:
[80-429]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
109
Blastp_CBE
93.69
100%
-131
- C1 -
-
5F94
1
GSK3B_HUMAN
A:
[1-346]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
---------------------------------------
2
PsiBlast_PDB
93.67
100%
-124
- C1 -
-
4ACD
1
GSK3B_HUMAN
A:
[80-429]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
29
Blastp_CBE
93.54
100%
-124
- C1 -
-
6H0U
3
GSK3B_HUMAN
B:
[36-383]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
121
Blastp_CBE
93.52
99%
-125
- C1 -
-
6HK3
4
GSK3B_HUMAN
B:
[1-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
555
HHSearch
93.43
100%
-125
- C1 -
-
4NM3
6
GSK3B_HUMAN
A:
[6-384]
-----
R
T
T
S
F
---------------
M
K
V
S
R
----
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
H
------------------------------------
25
Blastp_CBE
93.42
100%
-124
- C1 -
-
4ACH
1
GSK3B_HUMAN
B:
[80-429]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
122
Blastp_CBE
93.39
99%
-127
- C1 -
-
6HK3
5
GSK3B_HUMAN
A:
[1-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
88
Blastp_CBE
93.39
100%
-122
- C1 -
-
4NM7
5
GSK3B_HUMAN
A:
[13-371]
------------------------
S
M
K
V
S
R
D
---
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
68
Blastp_CBE
93.32
100%
-129
- C1 -
-
6GJO
1
GSK3B_HUMAN
A:
[29-377]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
119
Blastp_CBE
93.30
99%
-125
- C1 -
-
6HK4
10
GSK3B_HUMAN
B:
[1-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
87
Blastp_CBE
93.28
99%
-125
- C1 -
-
4NM3
6
GSK3B_HUMAN
A:
[6-383]
-----
R
T
T
---------------
G
S
M
K
V
S
R
----
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
60
Blastp_CBE
93.25
99%
-127
- C1 -
-
4J71
1
GSK3B_HUMAN
A:
[40-387]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
3
PsiBlast_PDB
93.22
100%
-120
- C1 -
-
4ACG
1
GSK3B_HUMAN
A:
[80-429]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
97
Blastp_CBE
93.20
100%
-131
- C1 -
-
2O5K
1
GSK3B_HUMAN
A:
[14-363]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
108
Blastp_CBE
93.19
100%
-126
- C1 -
-
5F94
1
GSK3B_HUMAN
B:
[2-350]
------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
117
Blastp_CBE
92.85
99%
-125
- C1 -
-
1UV5
1
GSK3B_HUMAN
A:
[1-348]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
G
--------
K
------
A
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
120
Blastp_CBE
92.84
99%
-122
- C1 -
-
6HK4
9
GSK3B_HUMAN
A:
[1-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
26
Blastp_CBE
92.70
100%
-122
- C1 -
-
4ACG
1
GSK3B_HUMAN
B:
[80-429]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
22
Blastp_CBE
92.62
100%
-125
- C1 -
-
4PTE
1
GSK3B_HUMAN
B:
[57-406]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
---
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
94
Blastp_CBE
92.61
99%
-122
- C1 -
-
3ZRK
2
GSK3B_HUMAN
B:
[14-362]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
27
Blastp_CBE
92.44
100%
-123
- C1 -
-
4ACD
1
GSK3B_HUMAN
B:
[80-429]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
71
Blastp_CBE
92.39
100%
-120
- C1 -
-
3I4B
1
GSK3B_HUMAN
B:
[30-376]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
48
Blastp_CBE
92.39
99%
-121
- C1 -
-
5OY4
1
GSK3B_HUMAN
A:
[36-385]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
90
Blastp_CBE
92.38
99%
-121
- C1 -
-
3ZRM
2
GSK3B_HUMAN
B:
[14-361]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
58
Blastp_CBE
92.18
99%
-132
- C1 -
-
5HLN
3
GSK3B_HUMAN
A:
[38-388]
---------------------------------
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
86
Blastp_CBE
92.17
99%
-120
- C1 -
-
4NU1
4
GSK3B_MOUSE
A:
[6-383]
----
P
R
T
T
-
F
A
--------------
M
K
V
S
-----
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
51
Blastp_CBE
92.09
99%
-131
- C1 -
-
5KPM
1
GSK3B_HUMAN
B:
[40-388]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
57
Blastp_CBE
92.06
99%
-121
- C1 -
-
5HLN
3
GSK3B_HUMAN
B:
[41-387]
------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
52
Blastp_CBE
91.88
99%
-131
- C1 -
-
5KPM
1
GSK3B_HUMAN
A:
[40-387]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
23
Blastp_CBE
91.87
100%
-128
- C1 -
-
4PTC
1
GSK3B_HUMAN
B:
[56-406]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
5
PsiBlast_PDB
91.78
100%
-134
- C1 -
-
4PTC
1
GSK3B_HUMAN
A:
[57-402]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
---------------------------------------
107
Blastp_CBE
91.75
100%
-126
- C1 -
-
5F95
1
GSK3B_HUMAN
A:
[1-348]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
----
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
92
Blastp_CBE
91.72
99%
-120
- C1 -
-
3ZRL
3
GSK3B_HUMAN
B:
[14-361]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
50
Blastp_CBE
91.56
99%
-127
- C1 -
-
3SAY
4
GSK3B_HUMAN
A:
[35-384]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
--
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
55
Blastp_CBE
91.28
99%
-127
- C1 -
-
5KPK
1
GSK3B_HUMAN
B:
[39-387]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
114
Blastp_CBE
91.23
99%
-128
- C1 -
-
2OW3
1
GSK3B_HUMAN
A:
[1-351]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
-----
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
31
Blastp_CBE
91.16
100%
-125
- C1 -
-
3M1S
1
GSK3B_HUMAN
B:
[35-384]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
-------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
32
Blastp_CBE
91.09
100%
-119
- C1 -
-
2JLD
1
GSK3B_HUMAN
B:
[35-384]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
-------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
123
Blastp_CBE
91.00
99%
-118
- C1 -
-
3ZDI
1
GSK3B_HUMAN
A:
[2-350]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
128
Blastp_CBE
90.87
99%
-121
- C1 -
-
6HK7
3
GSK3B_HUMAN
A:
[1-347]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
56
Blastp_CBE
90.84
99%
-121
- C1 -
-
5KPK
1
GSK3B_HUMAN
A:
[39-388]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
6
PsiBlast_PDB
90.84
100%
-127
- C1 -
-
4PTE
1
GSK3B_HUMAN
A:
[57-403]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
----------------
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
45
Blastp_CBE
90.74
99%
-126
- C1 -
-
6V6L
1
?
A:
[37-384]
------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
----------------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
67
Blastp_CBE
90.69
100%
-133
- C1 -
-
6GJO
1
GSK3B_HUMAN
B:
[29-377]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
47
Blastp_CBE
90.50
99%
-113
- C1 -
-
5OY4
1
GSK3B_HUMAN
B:
[30-384]
-----------------------------
R
D
K
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
557
HHSearch
90.38
100%
-124
- C1 -
-
4B7T
1
GSK3B_HUMAN
A:
[10-345]
-------------------------------------------
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
-----------------------------------------
102
Blastp_CBE
90.14
99%
-120
- C1 -
-
4AFJ
5
GSK3B_HUMAN
B:
[8-358]
---------------------------------
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
------------------
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
46
Blastp_CBE
90.03
99%
-126
- C1 -
-
6B8J
2
GSK3B_HUMAN
A:
[37-384]
------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
73
Blastp_CBE
89.53
100%
-122
- C1 -
-
1Q5K
1
GSK3B_HUMAN
B:
[29-378]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
----
E
F
---
K
---
F
P
---
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
13
PsiBlast_PDB
89.42
100%
-127
- C1 -
-
3M1S
1
GSK3B_HUMAN
A:
[35-385]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
-----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
105
Blastp_CBE
88.76
99%
-133
- C1 -
-
5K5N
1
GSK3B_HUMAN
A:
[22-368]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
---
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
-------------------
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
---------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
106
Blastp_CBE
88.72
100%
-125
- C1 -
-
5F95
1
GSK3B_HUMAN
B:
[1-350]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-------------------
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
30
Blastp_CBE
88.34
100%
-124
- C1 -
-
3PUP
1
GSK3B_HUMAN
B:
[35-383]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
-
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
12
PsiBlast_PDB
88.23
100%
-122
- C1 -
-
2JLD
1
GSK3B_HUMAN
A:
[35-385]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
-
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
93
Blastp_CBE
88.12
99%
-123
- C1 -
-
3ZRL
2
GSK3B_HUMAN
A:
[14-362]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
14
PsiBlast_PDB
88.07
100%
-125
- C1 -
-
3PUP
1
GSK3B_HUMAN
A:
[35-382]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
-
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
19
PsiBlast_PDB
88.03
100%
-127
- C1 -
-
1Q3W
1
GSK3B_HUMAN
A:
[39-390]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
--------
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
556
HHSearch
87.76
100%
-121
- C1 -
-
4AFJ
4
GSK3B_HUMAN
A:
[10-358]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
-----------------
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
95
Blastp_CBE
87.76
99%
-124
- C1 -
-
3ZRK
3
GSK3B_HUMAN
A:
[14-362]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
91
Blastp_CBE
87.60
99%
-125
- C1 -
-
3ZRM
2
GSK3B_HUMAN
A:
[14-361]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
74
Blastp_CBE
87.55
100%
-126
- C1 -
-
1Q5K
1
GSK3B_HUMAN
A:
[29-378]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
----
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
101
Blastp_CBE
87.47
99%
-118
- C1 -
-
6GN1
1
GSK3B_HUMAN
A:
[11-358]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
---------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
103
Blastp_CBE
87.43
99%
-121
- C1 -
-
4AFJ
4
GSK3B_HUMAN
A:
[10-358]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
-----------------
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
16
PsiBlast_PDB
87.42
100%
-123
- C1 -
-
1PYX
1
GSK3B_HUMAN
A:
[37-388]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
-----
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
38
Blastp_CBE
87.38
100%
-123
- C1 -
-
3Q3B
1
GSK3B_HUMAN
B:
[39-387]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
---------
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
100
Blastp_CBE
87.33
99%
-116
- C1 -
-
6GN1
1
GSK3B_HUMAN
B:
[11-358]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
---------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
18
PsiBlast_PDB
87.26
100%
-130
- C1 -
-
1Q3D
1
GSK3B_HUMAN
A:
[39-389]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
-------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
43
Blastp_CBE
87.16
100%
-126
- C1 -
-
1Q3W
1
GSK3B_HUMAN
B:
[39-387]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
---------
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
41
Blastp_CBE
87.16
100%
-124
- C1 -
-
1Q4L
1
GSK3B_HUMAN
A:
[39-390]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
--------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
53
Blastp_CBE
87.15
99%
-126
- C1 -
-
5KPL
1
GSK3B_HUMAN
B:
[40-387]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
76
Blastp_CBE
87.14
99%
-132
- C1 -
-
5HLP
1
GSK3B_HUMAN
A:
[40-386]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
----
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
104
Blastp_CBE
86.98
99%
-128
- C1 -
-
5K5N
1
GSK3B_HUMAN
B:
[22-370]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
---
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
-------------------
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-------------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
39
Blastp_CBE
86.94
100%
-124
- C1 -
-
3Q3B
1
GSK3B_HUMAN
A:
[39-390]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
--------
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
44
Blastp_CBE
86.53
100%
-128
- C1 -
-
1Q3D
1
GSK3B_HUMAN
B:
[39-387]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
-------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
40
Blastp_CBE
86.51
100%
-122
- C1 -
-
1Q4L
1
GSK3B_HUMAN
B:
[39-387]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
E
---------------
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
126
Blastp_CBE
86.45
99%
-128
- C1 -
-
3F88
1
GSK3B_HUMAN
B:
[1-349]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
---
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
118
Blastp_CBE
86.40
99%
-126
- C1 -
-
3GB2
1
GSK3B_HUMAN
A:
[5-353]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
----
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
37
Blastp_CBE
86.19
100%
-126
- C1 -
-
1PYX
1
GSK3B_HUMAN
B:
[37-385]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
-------
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
124
Blastp_CBE
86.16
99%
-129
- C1 -
-
3F7Z
1
GSK3B_HUMAN
B:
[2-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-
Y
T
----------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
36
Blastp_CBE
86.16
100%
-128
- C1 -
-
3DU8
1
GSK3B_HUMAN
B:
[37-387]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
-------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
75
Blastp_CBE
85.59
99%
-128
- C1 -
-
5HLP
1
GSK3B_HUMAN
B:
[40-387]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
-------------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
17
PsiBlast_PDB
85.59
100%
-125
- C1 -
-
3DU8
1
GSK3B_HUMAN
A:
[37-384]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
-------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
127
Blastp_CBE
85.52
99%
-121
- C1 -
-
3F88
1
GSK3B_HUMAN
A:
[1-349]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
---
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
7
PsiBlast_PDB
85.45
100%
-133
- C1 -
-
4PTG
1
GSK3B_HUMAN
A:
[57-403]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
-------
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
---------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
54
Blastp_CBE
85.26
99%
-125
- C1 -
-
5KPL
1
GSK3B_HUMAN
A:
[40-388]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
--------------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
125
Blastp_CBE
85.03
99%
-119
- C1 -
-
3F7Z
1
GSK3B_HUMAN
A:
[2-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
E
---
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
N
--------------
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
24
Blastp_CBE
84.89
100%
-137
- C1 -
-
4IQ6
1
GSK3B_HUMAN
B:
[43-388]
------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
---------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
21
Blastp_CBE
84.67
100%
-130
- C1 -
-
4PTG
1
GSK3B_HUMAN
B:
[58-406]
------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
--------------------
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
66
Blastp_CBE
84.59
99%
-132
- C1 -
-
5T31
1
GSK3B_HUMAN
A:
[35-381]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
K
D
E
V
Y
L
N
L
V
L
E
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
----------------
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
---------------------------------------
65
Blastp_CBE
84.48
99%
-130
- C1 -
-
5T31
1
GSK3B_HUMAN
B:
[36-382]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-------
V
Y
L
N
L
V
L
E
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
P
--------------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
70
Blastp_CBE
84.35
100%
-124
- C1 -
-
3L1S
1
GSK3B_HUMAN
A:
[19-378]
------------------------
S
M
K
V
S
R
D
---
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
--------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
---------------------
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
69
Blastp_CBE
83.90
100%
-129
- C1 -
-
3L1S
1
GSK3B_HUMAN
B:
[30-376]
-----------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
----------------------
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
8
PsiBlast_PDB
83.10
100%
-131
- C1 -
-
4IQ6
1
GSK3B_HUMAN
A:
[43-388]
------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
---------
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
N
---------------------
P
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
96
Blastp_CBE
81.16
99%
-125
- C1 -
-
4DIT
1
GSK3B_HUMAN
A:
[13-365]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
--
L
Q
D
--------
K
------
R
F
K
N
------
R
---
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
-
R
G
E
P
-----
N
-------
V
S
----
I
---
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
----
I
R
E
M
-----------------------
W
T
K
V
F
R
P
R
T
P
---
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
---------------------------------
131
Blastp_CBE
67.53
46%
-143
- C1 -
-
3EB0
3
?
A:
[9-365]
-------------------------------------------------------------------
Y
S
L
G
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
E
S
-
G
K
R
F
A
L
K
K
V
--
L
Q
D
--------
P
------
R
Y
K
N
------
R
---
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
Y
T
T
------
N
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
-
P
S
E
P
-----
S
-------
V
A
Y
---
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
G
K
P
L
F
S
G
E
T
S
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
-
K
E
--
Q
----
M
I
R
M
N
P
H
-
Y
--
V
---
R
---
F
P
T
L
K
A
K
D
W
R
K
I
L
P
E
G
T
P
---
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
---------
I
P
Q
L
F
N
F
S
P
Y
E
L
S
I
I
P
-------------------------------------------------
130
Blastp_CBE
65.74
46%
-141
- C1 -
-
3EB0
3
?
C:
[9-365]
-------------------------------------------------------------------
Y
S
L
G
K
T
L
G
T
--
F
G
I
V
C
E
V
F
D
I
E
S
-
G
K
R
F
A
L
K
K
V
--
L
Q
D
--------
P
------
R
Y
K
N
------
R
---
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
Y
T
T
------
N
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
G
R
S
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
-
P
S
E
P
-----
S
-------
V
A
Y
---
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
G
K
P
L
F
S
G
E
T
S
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
-
K
E
--
Q
----
M
I
R
M
N
P
H
-
Y
--
V
---
R
---
F
P
T
L
K
A
K
D
W
R
K
I
L
P
E
G
T
P
---
S
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
--------
N
I
P
Q
L
F
N
F
S
P
Y
E
L
S
I
I
P
-------------------------------------------------
480
Blastp_CBE
48.90
33%
-78
- C1 -
-
2FVD
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------------
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
--
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
408
Blastp_CBE
47.26
33%
-45
- C1 -
-
4EK8
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
----------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
475
Blastp_CBE
47.27
33%
-34
- C1 -
-
2R3G
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
376
Blastp_CBE
47.26
33%
-46
- C1 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
----------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
482
Blastp_CBE
47.16
33%
-48
- C1 -
-
2DUV
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------I-----
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
----------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
398
Blastp_CBE
47.03
33%
-42
- C1 -
-
4FKT
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
----------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
278
Blastp_CBE
46.91
33%
-40
- C1 -
-
6Q4J
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
-------
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
455
Blastp_CBE
46.77
33%
-45
- C1 -
-
2VTS
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
----------------------HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
450
Blastp_CBE
46.73
33%
-36
- C1 -
-
2W06
2
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
----------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
562
HHSearch
46.72
34%
-13
- C1 -
-
4IC7
1
MK07_HUMAN
A:
[53-356]
---------------------------------------------------
V
G
D
E
------------
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
-
G
Q
Q
V
A
I
K
K
I
--
P
N
A
--------
F
DVVTNA
K
R
T
L
------
R
---
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
-
T
S
P
A
EHQYF
M
-------
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
----
I
Q
A
V
G
A
E
-
R
V
R
A
---
Y
IQS
L
P
P
R
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
---
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
-------------------------------------------------------------------------
140
Blastp_CBE
46.66
35%
-9
- C1 -
-
4QTB
6
MK03_HUMAN
B:
[28-337]
----------------------------------------------------
E
V
E
MVKGQPFDVGPR
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
V
R
-
K
T
R
V
A
I
K
K
I
SP
F
E
H
--------
Q
------
T
Y
C
Q
------
R
TLR
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
A
S
T
L
E
A
M
R
D
V
Y
I
--
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
-----
S
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
I
----
A
D
P
-----
E
HDHTGFL
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
-
Q
E
--
D
LNCI
I
N
M
K
A
R
N
-
Y
L
Q
----
S
---
L
P
S
K
T
K
V
A
W
A
K
L
F
-
P
K
S
D
---
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
--------------------------------------------------------------------------
453
Blastp_CBE
46.61
33%
-44
- C1 -
-
2VU3
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
----
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
567
HHSearch
46.60
34%
-10
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[5-307]
----------------------------------------------------
G
D
E
------------
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
-
G
Q
Q
V
A
I
K
K
I
--
P
N
A
--------
F
DVVTNA
K
R
T
L
------
R
---
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
-
T
S
P
A
EHQYF
M
-------
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
----
I
Q
A
V
G
A
E
-
R
V
R
A
YIQ
S
---
L
P
P
R
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
---
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
-------------------------------------------------------------------------
429
Blastp_CBE
46.47
33%
-31
- C1 -
-
3LFQ
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
565
HHSearch
46.45
34%
-12
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[6-308]
----------------------------------------------------
G
D
E
------------
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
-
G
Q
Q
V
A
I
K
K
I
--
P
N
A
--------
F
DVVTNA
K
R
T
L
------
R
---
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
-
T
S
P
A
EHQYF
M
-------
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
----
I
Q
A
V
G
A
E
-
R
V
R
A
YIQ
S
---
L
P
P
R
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
---
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
-------------------------------------------------------------------------
289
Blastp_CBE
46.44
33%
-45
- C1 -
-
6GUH
3
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
-----------------------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
378
Blastp_CBE
46.40
33%
-30
- C1 -
-
5IEY
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-------------------
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
-----------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
396
Blastp_CBE
46.39
33%
-37
- C1 -
-
4FKV
2
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-------------------
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
------------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
449
Blastp_CBE
46.09
33%
-40
- C1 -
-
2W17
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
-------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
--
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
458
Blastp_CBE
46.01
33%
-38
- C1 -
-
2VTP
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
----------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
531
Blastp_CBE
45.98
33%
-34
- C1 -
-
1KE9
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
406
Blastp_CBE
46.04
33%
-28
- C1 -
-
4FKI
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
---------------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
300
Blastp_CBE
46.01
33%
-31
- C1 -
-
3RPR
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
298
Blastp_CBE
46.01
33%
-37
- C1 -
-
3RPY
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
420
Blastp_CBE
45.98
33%
-31
- C1 -
-
3ULI
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
-------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
-----------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
280
Blastp_CBE
45.96
33%
-41
- C1 -
-
6Q4E
3
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
436
Blastp_CBE
45.95
33%
-11
- C1 -
-
3F5X
2
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
390
Blastp_CBE
45.94
33%
-34
- C1 -
-
5A14
2
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
395
Blastp_CBE
45.88
33%
-33
- C1 -
-
4FKW
2
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-------------------
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
424
Blastp_CBE
45.87
33%
-38
- C1 -
-
3SW7
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
501
Blastp_CBE
45.84
33%
-33
- C1 -
-
2BTR
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
-------------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
516
Blastp_CBE
45.76
33%
-34
- C1 -
-
1V1K
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
---------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
405
Blastp_CBE
45.75
33%
-32
- C1 -
-
4FKJ
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
--------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
377
Blastp_CBE
45.74
33%
-32
- C1 -
-
5JQ5
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
141
Blastp_CBE
45.67
35%
-6
- C1 -
-
4QTB
16
MK03_HUMAN
A:
[25-337]
-------------------------------------------------
V
P
G
E
V
E
MVKGQPFDVGPR
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
V
R
-
K
T
R
V
A
I
K
K
I
SP
F
E
H
--------
Q
------
T
Y
C
Q
------
R
TLR
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
A
S
T
L
E
A
M
R
D
V
Y
I
--
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
-----
S
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
I
----
A
D
P
-----
E
HDHTGFL
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
-
Q
E
--
D
LNCI
I
N
M
K
A
R
N
-
Y
L
Q
----
S
---
L
P
S
K
T
K
V
A
W
A
K
L
F
-
P
K
S
D
---
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
--------------------------------------------------------------------------
425
Blastp_CBE
45.61
33%
-29
- C1 -
-
3SW4
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
464
Blastp_CBE
45.58
33%
-31
- C1 -
-
2VTI
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
304
Blastp_CBE
45.57
33%
-40
- C1 -
-
3RMF
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
532
Blastp_CBE
45.54
33%
-29
- C1 -
-
1KE8
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
413
Blastp_CBE
45.46
33%
-27
- C1 -
-
4D1X
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
276
Blastp_CBE
45.50
33%
-34
- C1 -
-
5K4J
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
-----------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
288
Blastp_CBE
45.48
33%
-28
- C1 -
-
6GUK
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
399
Blastp_CBE
45.46
33%
-31
- C1 -
-
4FKS
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
---------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
313
Blastp_CBE
45.45
33%
-44
- C1 -
-
3RAK
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
315
Blastp_CBE
45.43
33%
-29
- C1 -
-
3RAH
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
312
Blastp_CBE
45.42
33%
-40
- C1 -
-
3RAL
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
513
Blastp_CBE
45.33
33%
-26
- C1 -
-
1WCC
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
400
Blastp_CBE
45.36
33%
-26
- C1 -
-
4FKR
2
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
354
Blastp_CBE
45.39
33%
-28
- C1 -
-
3QTS
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
407
Blastp_CBE
45.38
33%
-22
- C1 -
-
4FKG
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
---------------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
355
Blastp_CBE
45.37
33%
-31
- C1 -
-
3QTR
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
294
Blastp_CBE
45.36
33%
-37
- C1 -
-
3S1H
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
373
Blastp_CBE
45.32
33%
-33
- C1 -
-
6INL
1
?
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
------------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
417
Blastp_CBE
45.35
33%
-28
- C1 -
-
3WBL
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-------------------
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
277
Blastp_CBE
45.33
33%
-16
- C1 -
-
6Q4K
3
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
317
Blastp_CBE
45.32
33%
-30
- C1 -
-
3R9N
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
561
HHSearch
45.31
34%
-31
- C1 -
-
4B99
1
MK07_HUMAN
A:
[52-355]
---------------------------------------------------
V
G
D
E
------------
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
-
G
Q
Q
V
A
I
K
K
I
--
P
N
A
FDVVTN--
A
------
K
R
T
L
------
R
---
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
------QYF--
M
-------
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
----
I
Q
-----R
V
R
A
Y
IQ-
S
---
L
P
P
R
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
---
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
-------------------------------------------------------------------------
452
Blastp_CBE
45.24
33%
-33
- C1 -
-
2VV9
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
385
Blastp_CBE
45.28
33%
-19
- C1 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
-----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
282
Blastp_CBE
45.24
33%
-22
- C1 -
-
6Q4C
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
502
Blastp_CBE
45.23
33%
-36
- C1 -
-
2BHH
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
------------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
428
Blastp_CBE
45.22
33%
-16
- C1 -
-
3LFS
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
535
Blastp_CBE
45.19
33%
-33
- C1 -
-
1KE5
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
401
Blastp_CBE
45.16
33%
-27
- C1 -
-
4FKQ
2
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
379
Blastp_CBE
45.14
33%
-20
- C1 -
-
5IEX
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-------------------
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
533
Blastp_CBE
45.04
33%
-31
- C1 -
-
1KE7
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
139
Blastp_CBE
45.11
35%
-2
- C1 -
-
6GES
4
MK03_HUMAN
A:
[26-337]
--------------------------------------------------
P
G
E
V
E
MVKGQPFDVGPR
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
V
R
-
K
T
R
V
A
I
K
K
I
SP
F
E
H
--------
Q
------
T
Y
C
Q
------
R
TLR
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
A
S
T
L
E
A
M
R
D
V
Y
I
--
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
-----
S
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
I
----
A
D
P
-----
E
HDHTGFL
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
-
Q
E
--
D
LNCI
I
N
M
K
A
R
N
-
Y
L
Q
----
S
---
L
P
S
K
T
K
V
A
W
A
K
L
F
-
P
K
S
D
---
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
--------------------------------------------------------------------------
381
Blastp_CBE
45.07
33%
-30
- C1 -
-
5FP6
2
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
-------------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
448
Blastp_CBE
45.09
33%
-25
- C1 -
-
2W1H
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
410
Blastp_CBE
45.04
33%
-18
- C1 -
-
4EK5
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
508
Blastp_CBE
45.08
33%
-19
- C1 -
-
2A4L
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------AI----
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
380
Blastp_CBE
45.07
33%
-26
- C1 -
-
5IEV
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-------------------
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
275
Blastp_CBE
45.04
33%
-24
- C1 -
-
3PJ8
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
-----------------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
466
Blastp_CBE
45.01
33%
-27
- C1 -
-
2VTA
3
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
497
Blastp_CBE
45.00
33%
-8
- C1 -
-
2C5O
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
474
Blastp_CBE
44.91
33%
-19
- C1 -
-
2R3H
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
460
Blastp_CBE
44.96
33%
-36
- C1 -
-
2VTN
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
-------------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
472
Blastp_CBE
44.93
33%
-29
- C1 -
-
2R64
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
253
Blastp_CBE
44.91
33%
-35
- C1 -
-
3EZV
1
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
-----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
416
Blastp_CBE
44.88
33%
-33
- C1 -
-
4ACM
3
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
---------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
469
Blastp_CBE
44.77
33%
-28
- C1 -
-
2UZN
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
441
Blastp_CBE
44.77
33%
-24
- C1 -
-
3EID
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
T--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
496
Blastp_CBE
44.82
33%
-1
- C1 -
-
2C5O
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
402
Blastp_CBE
44.81
33%
-27
- C1 -
-
4FKP
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
391
Blastp_CBE
44.77
33%
-23
- C1 -
-
4LYN
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
465
Blastp_CBE
44.67
33%
-27
- C1 -
-
2VTH
2
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
504
Blastp_CBE
44.66
33%
-37
- C1 -
-
2B55
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
-----------------------
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
------------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
511
Blastp_CBE
44.73
33%
-23
- C1 -
-
1Y91
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
-----------------
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
290
Blastp_CBE
44.71
33%
-12
- C1 -
-
4GCJ
5
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
507
Blastp_CBE
44.68
33%
-16
- C1 -
-
2B52
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
-------------------------HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
388
Blastp_CBE
44.67
33%
-9
- C1 -
-
5ANE
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
384
Blastp_CBE
44.66
33%
-33
- C1 -
-
5ANK
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
-----------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
498
Blastp_CBE
44.59
33%
-6
- C1 -
-
2C5N
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
479
Blastp_CBE
44.65
33%
-23
- C1 -
-
2I40
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
421
Blastp_CBE
44.60
33%
-11
- C1 -
-
3TIZ
9
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
324
Blastp_CBE
44.60
33%
-26
- C1 -
-
3R8M
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
403
Blastp_CBE
44.59
33%
-20
- C1 -
-
4FKO
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
473
Blastp_CBE
44.58
33%
-6
- C1 -
-
2R3R
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
279
Blastp_CBE
44.57
33%
-23
- C1 -
-
6Q4H
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
-------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
-------
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
341
Blastp_CBE
44.56
33%
-7
- C1 -
-
3QZG
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
514
Blastp_CBE
44.48
33%
-23
- C1 -
-
1W0X
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
470
Blastp_CBE
44.55
33%
-6
- C1 -
-
2UUE
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
456
Blastp_CBE
44.54
33%
-14
- C1 -
-
2VTR
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
527
Blastp_CBE
44.46
33%
-6
- C1 -
-
1PXI
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
386
Blastp_CBE
44.50
33%
-28
- C1 -
-
5ANI
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
435
Blastp_CBE
44.53
33%
-4
- C1 -
-
3F5X
2
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
471
Blastp_CBE
44.46
33%
-2
- C1 -
-
2UUE
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
342
Blastp_CBE
44.51
33%
-9
- C1 -
-
3QZF
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
526
Blastp_CBE
44.43
33%
-5
- C1 -
-
1PXJ
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
325
Blastp_CBE
44.50
33%
-8
- C1 -
-
3R8L
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
457
Blastp_CBE
44.42
33%
-31
- C1 -
-
2VTQ
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
------------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
149
Blastp_CBE
44.47
34%
-15
- C1 -
-
5OO3
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
132
Blastp_CBE
44.47
37%
-20
- C1 -
-
3NIZ
1
?
A:
[23-311]
-------------------------------------------------------------------
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
--
D
S
Q
G
R
I
V
A
L
K
R
I
--
R
--------------------
G
IPSTAI
R
---
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
S
-------
E
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
---
D
E
N
K
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
G
A
-
L
K
L
A
D
F
G
L
A
R
A
F
---
G
I
P
-----
V
-------
R
--HE-
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
WP
Q
----
V
Q
E
L
-
P
L
-
W
K
Q
R
---
T
---
F
Q
V
F
E
K
K
P
W
S
S
I
I
-
P
G
F
C
---
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
-
D
P
Q
I
------------------------------------------------------------------------
148
Blastp_CBE
44.46
34%
-13
- C1 -
-
5OSM
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
383
Blastp_CBE
44.43
33%
-52
- C1 -
-
5D1J
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
-------------------------I-----
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
--------------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
316
Blastp_CBE
44.42
33%
-25
- C1 -
-
3R9O
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
431
Blastp_CBE
44.32
33%
-23
- C1 -
-
3LE6
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
415
Blastp_CBE
44.41
33%
-34
- C1 -
-
4BGH
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
-----------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
360
Blastp_CBE
44.38
33%
-5
- C1 -
-
3QQK
6
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
322
Blastp_CBE
44.40
33%
-8
- C1 -
-
3R8U
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
499
Blastp_CBE
44.32
33%
-3
- C1 -
-
2C5N
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
287
Blastp_CBE
44.38
33%
-28
- C1 -
-
6Q3B
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
365
Blastp_CBE
44.34
33%
-8
- C1 -
-
3QL8
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
284
Blastp_CBE
44.37
33%
-16
- C1 -
-
6Q4A
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
-------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
361
Blastp_CBE
44.34
33%
-9
- C1 -
-
3QQJ
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
443
Blastp_CBE
44.30
33%
-4
- C1 -
-
2XMY
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
---------
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
349
Blastp_CBE
44.32
33%
-9
- C1 -
-
3QU0
5
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
299
Blastp_CBE
44.34
33%
-4
- C1 -
-
3RPV
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
510
Blastp_CBE
44.33
33%
-3
- C1 -
-
1YKR
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
318
Blastp_CBE
44.32
33%
-8
- C1 -
-
3R9H
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
393
Blastp_CBE
44.31
33%
-5
- C1 -
-
4FX3
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
352
Blastp_CBE
44.30
33%
-8
- C1 -
-
3QTW
6
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
323
Blastp_CBE
44.26
33%
-10
- C1 -
-
3R8P
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
319
Blastp_CBE
44.26
33%
-6
- C1 -
-
3R9D
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
409
Blastp_CBE
44.21
33%
-22
- C1 -
-
4EK6
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
-----------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
404
Blastp_CBE
44.21
33%
-9
- C1 -
-
4FKL
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
509
Blastp_CBE
44.14
33%
-8
- C1 -
-
2A0C
1
CDK2_HUMAN
X:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
310
Blastp_CBE
44.21
33%
-9
- C1 -
-
3RK5
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
445
Blastp_CBE
44.14
33%
-3
- C1 -
-
2X1N
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
369
Blastp_CBE
44.18
33%
-6
- C1 -
-
3PXY
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
297
Blastp_CBE
44.17
33%
-29
- C1 -
-
3RZB
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
451
Blastp_CBE
44.09
33%
-29
- C1 -
-
2W05
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
--------------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
308
Blastp_CBE
44.12
33%
-9
- C1 -
-
3RK9
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
359
Blastp_CBE
44.14
33%
-3
- C1 -
-
3QQL
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
430
Blastp_CBE
44.09
33%
-13
- C1 -
-
3LFN
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
-----------------------HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
488
Blastp_CBE
44.13
33%
-9
- C1 -
-
2C6I
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
283
Blastp_CBE
44.12
33%
-18
- C1 -
-
6Q4B
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
419
Blastp_CBE
44.09
33%
-10
- C1 -
-
3UNJ
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
351
Blastp_CBE
44.07
33%
-7
- C1 -
-
3QTX
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
520
Blastp_CBE
44.06
33%
-5
- C1 -
-
1PXP
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
529
Blastp_CBE
43.92
33%
-30
- C1 -
-
1P2A
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------AI----
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
-----------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
309
Blastp_CBE
44.00
33%
-8
- C1 -
-
3RK7
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
506
Blastp_CBE
43.95
33%
-11
- C1 -
-
2B53
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
495
Blastp_CBE
43.92
33%
-4
- C1 -
-
2C5V
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
353
Blastp_CBE
43.89
33%
-5
- C1 -
-
3QTU
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
476
Blastp_CBE
43.88
33%
-6
- C1 -
-
2R3F
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
418
Blastp_CBE
43.87
33%
-7
- C1 -
-
3UNK
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
-----------------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
481
Blastp_CBE
43.80
33%
-1
- C1 -
-
2EXM
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
382
Blastp_CBE
43.86
33%
-34
- C1 -
-
5FP5
3
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
----------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
-------------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
521
Blastp_CBE
43.78
33%
-3
- C1 -
-
1PXO
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
303
Blastp_CBE
43.85
33%
-9
- C1 -
-
3RNI
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
394
Blastp_CBE
43.83
33%
-3
- C1 -
-
4FX3
2
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
492
Blastp_CBE
43.82
33%
-3
- C1 -
-
2C5X
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
454
Blastp_CBE
43.81
33%
-30
- C1 -
-
2VTT
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
------------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
367
Blastp_CBE
43.80
33%
-9
- C1 -
-
3PY0
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
426
Blastp_CBE
43.74
33%
-27
- C1 -
-
3S2P
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
484
Blastp_CBE
43.78
33%
-10
- C1 -
-
2C6O
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
523
Blastp_CBE
43.77
33%
-6
- C1 -
-
1PXM
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
296
Blastp_CBE
43.75
33%
-5
- C1 -
-
3S00
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
356
Blastp_CBE
43.74
33%
-7
- C1 -
-
3QTQ
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
483
Blastp_CBE
43.73
33%
-8
- C1 -
-
2CLX
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-------------------
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
447
Blastp_CBE
43.66
33%
-2
- C1 -
-
2WEV
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
320
Blastp_CBE
43.71
33%
-9
- C1 -
-
3R8Z
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
----------------THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
518
Blastp_CBE
43.63
33%
-28
- C1 -
-
1R78
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
-------------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
362
Blastp_CBE
43.66
33%
-7
- C1 -
-
3QQH
4
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
500
Blastp_CBE
43.68
33%
-25
- C1 -
-
2BTS
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
------------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
525
Blastp_CBE
43.60
33%
-10
- C1 -
-
1PXK
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
358
Blastp_CBE
43.67
33%
-5
- C1 -
-
3QRT
3
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
343
Blastp_CBE
43.66
33%
-10
- C1 -
-
3QXP
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
311
Blastp_CBE
43.65
33%
-7
- C1 -
-
3RJC
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
414
Blastp_CBE
43.64
33%
-29
- C1 -
-
4BZD
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
-----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
363
Blastp_CBE
43.60
33%
-5
- C1 -
-
3QQG
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
505
Blastp_CBE
43.63
33%
-4
- C1 -
-
2B54
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
512
Blastp_CBE
43.61
33%
-7
- C1 -
-
1Y8Y
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
321
Blastp_CBE
43.60
33%
-7
- C1 -
-
3R8V
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
442
Blastp_CBE
43.58
33%
-4
- C1 -
-
2XNB
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
291
Blastp_CBE
43.57
33%
-6
- C1 -
-
4EZ7
7
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
357
Blastp_CBE
43.52
33%
-7
- C1 -
-
3QRU
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
144
Blastp_CBE
43.51
34%
-19
- C1 -
-
2ZOQ
1
MK03_HUMAN
B:
[27-339]
-------------------------------------------------
V
P
G
E
V
E
MVKGQPFDVGPR
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
D
H
V
R
-
K
T
R
V
A
I
K
K
I
SP
F
E
H
--------
Q
------
T
Y
C
Q
------
R
TLR
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
A
S
T
L
E
A
M
R
D
V
Y
I
--
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
-----
S
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
-
T
C
D
L
K
I
C
D
F
G
L
A
R
I
A
D
-
P
E
H
D
-----
H
-------
T
G
F
LTE
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
-
Q
E
--
D
LNCI
I
N
M
K
A
R
N
-
Y
L
Q
----
S
---
L
P
S
K
T
K
V
A
W
A
K
L
F
-
P
K
S
D
---
S
K
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
--------------------------------------------------------------------------
423
Blastp_CBE
43.46
33%
-8
- C1 -
-
3TI1
9
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
522
Blastp_CBE
43.49
33%
-10
- C1 -
-
1PXN
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
446
Blastp_CBE
43.43
33%
-1
- C1 -
-
2WEV
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
434
Blastp_CBE
43.43
33%
-11
- C1 -
-
3FZ1
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
------------------HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
487
Blastp_CBE
43.48
33%
-6
- C1 -
-
2C6K
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
366
Blastp_CBE
43.47
33%
-8
- C1 -
-
3PY1
4
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
292
Blastp_CBE
43.46
33%
-9
- C1 -
-
4EZ3
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
459
Blastp_CBE
43.37
33%
-13
- C1 -
-
2VTO
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
----------------------HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
392
Blastp_CBE
43.43
33%
-2
- C1 -
-
4KD1
2
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
432
Blastp_CBE
43.37
33%
-5
- C1 -
-
3IGG
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
493
Blastp_CBE
43.41
33%
-1
- C1 -
-
2C5X
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
461
Blastp_CBE
43.39
33%
-7
- C1 -
-
2VTM
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
468
Blastp_CBE
43.38
33%
-8
- C1 -
-
2UZO
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
142
Blastp_CBE
43.37
35%
1
- C1 -
-
4QNY
2
?
B:
[22-336]
-------------------------------------------------------------------
Y
L
L
E
R
I
I
G
A
G
S
Y
G
V
V
I
R
A
R
D
T
K
S
D
N
R
L
V
A
M
K
R
V
--
N
K
E
IFEEVILA
K
------
R
I
L
-------
R
---
E
I
K
L
L
A
H
F
N
D
D
N
I
I
G
L
R
N
I
L
T
P
E
D
P
E
N
F
D
H
F
Y
I
--
V
M
D
I
M
E
T
D
L
K
Q
V
L
R
----
S
G
Q
E
L
T
E
A
H
I
Q
F
F
I
Y
Q
A
L
R
A
L
H
I
I
H
S
A
G
V
I
H
R
D
I
T
P
A
N
I
L
V
N
T
N
C
D
-
L
K
I
C
D
F
G
L
A
K
E
E
N
D
Q
--
Y
-----
M
-------
T
D
Y
---
V
T
M
R
W
Y
R
A
P
E
L
V
M
E
D
K
D
Y
S
A
Q
I
D
V
W
G
I
G
C
I
L
G
E
L
L
G
S
R
P
L
F
Q
G
K
D
R
V
N
Q
L
D
K
I
V
D
V
I
G
T
P
S
-
E
E
--
D
----
I
N
S
V
G
S
S
-
A
A
Q
----
K
---
Y
L
K
K
K
S
H
R
P
Q
A
D
W
R
Q
R
Y
P
TAS
P
E
A
L
D
L
L
R
H
M
L
V
F
N
P
K
R
R
I
T
V
L
Q
A
M
R
H
P
F
L
E
Q
L
H
D
D
----
A
D
D
---
Y
A
L
F
R
F
D
E
N
E
------------------------------------------------------
528
Blastp_CBE
43.25
33%
-8
- C1 -
-
1PF8
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
467
Blastp_CBE
43.25
33%
-7
- C1 -
-
2V0D
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
517
Blastp_CBE
43.31
33%
-30
- C1 -
-
1URW
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
--------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
485
Blastp_CBE
43.30
33%
-7
- C1 -
-
2C6M
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
307
Blastp_CBE
43.29
33%
-4
- C1 -
-
3RKB
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
350
Blastp_CBE
43.25
33%
-5
- C1 -
-
3QTZ
3
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
478
Blastp_CBE
43.23
33%
-5
- C1 -
-
2I40
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
368
Blastp_CBE
43.18
33%
-4
- C1 -
-
3PXZ
3
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
387
Blastp_CBE
43.11
33%
-33
- C1 -
-
5ANG
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------STAI--
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
----------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
-----------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
254
Blastp_CBE
43.11
33%
-26
- C1 -
-
3EZR
2
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
---------------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
494
Blastp_CBE
43.05
33%
-1
- C1 -
-
2C5V
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
440
Blastp_CBE
43.04
33%
-5
- C1 -
-
3EJ1
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
371
Blastp_CBE
43.00
33%
-6
- C1 -
-
3PXQ
4
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
281
Blastp_CBE
43.00
33%
-18
- C1 -
-
6Q4D
6
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------PSTAI-
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
438
Blastp_CBE
42.95
33%
-2
- C1 -
-
3EOC
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
427
Blastp_CBE
42.91
33%
-4
- C1 -
-
3NS9
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
-----------------------
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
524
Blastp_CBE
42.84
33%
-7
- C1 -
-
1PXL
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
490
Blastp_CBE
42.80
33%
-7
- C1 -
-
2C68
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
486
Blastp_CBE
42.74
33%
-5
- C1 -
-
2C6L
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
---------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
293
Blastp_CBE
42.71
33%
-8
- C1 -
-
3SQQ
2
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
---------------------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
437
Blastp_CBE
42.69
33%
-4
- C1 -
-
3EOC
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
489
Blastp_CBE
42.68
33%
-5
- C1 -
-
2C69
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
--------------------VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
530
Blastp_CBE
42.67
33%
-33
- C1 -
-
1OIQ
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
----------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
-------------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
519
Blastp_CBE
42.54
33%
-35
* C1 *
-
1PYE
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------TAI---
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
---------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
-------------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
439
Blastp_CBE
42.49
33%
-3
- C1 -
-
3EJ1
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
412
Blastp_CBE
41.63
33%
-26
- C1 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
------------------------AI----
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
--------------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
295
Blastp_CBE
41.42
33%
-7
- C1 -
-
3S0O
1
CDK2_HUMAN
A:
[11-300]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
--
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
266
Blastp_CBE
40.96
33%
-9
- C1 -
-
2UZB
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
206
Blastp_CBE
40.89
33%
-10
- C1 -
-
1E9H
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
265
Blastp_CBE
40.52
33%
-9
- C1 -
-
2UZB
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
252
Blastp_CBE
40.47
33%
-4
- C1 -
-
4I3Z
4
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
218
Blastp_CBE
40.45
33%
-8
- C1 -
-
1H1S
1
CDK2_HUMAN
C:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
220
Blastp_CBE
40.44
33%
-7
- C1 -
-
1H1R
1
CDK2_HUMAN
C:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
262
Blastp_CBE
40.38
33%
-5
- C1 -
-
2UZE
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
245
Blastp_CBE
40.38
33%
-6
- C1 -
-
1QMZ
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
223
Blastp_CBE
40.38
33%
-7
- C1 -
-
1H1Q
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
208
Blastp_CBE
40.37
33%
-8
- C1 -
-
5NEV
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
229
Blastp_CBE
40.34
33%
-4
- C1 -
-
3QHR
6
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
155
Blastp_CBE
40.35
33%
-9
- C1 -
-
6GUC
1
CDK2_HUMAN
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
207
Blastp_CBE
40.34
33%
-6
- C1 -
-
5NEV
1
?
C:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
147
Blastp_CBE
40.27
34%
-6
- C1 -
-
2IW8
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
159
Blastp_CBE
40.24
33%
-7
- C1 -
-
4CFN
1
CDK2_HUMAN
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
238
Blastp_CBE
40.23
33%
-6
- C1 -
-
3DDP
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
227
Blastp_CBE
40.21
33%
-4
- C1 -
-
3QHW
2
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
258
Blastp_CBE
40.18
33%
-3
- C1 -
-
4II5
2
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
165
Blastp_CBE
40.17
33%
-9
- C1 -
-
1OI9
1
CDK2_HUMAN
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
226
Blastp_CBE
40.12
33%
-4
- C1 -
-
3QHW
3
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
269
Blastp_CBE
40.11
33%
-5
- C1 -
-
2C6T
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
210
Blastp_CBE
40.08
33%
-5
- C1 -
-
5CYI
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
228
Blastp_CBE
40.07
33%
-3
- C1 -
-
3QHR
2
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
257
Blastp_CBE
40.05
33%
-4
- C1 -
-
4II5
3
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
240
Blastp_CBE
40.03
33%
-5
- C1 -
-
2G9X
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
170
Blastp_CBE
40.03
34%
-3
- C1 -
-
4CFV
1
CDK2_HUMAN
A:
[3-297]
------------------------------------------------
P
G
S
M
E
-
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
251
Blastp_CBE
39.97
33%
-2
- C1 -
-
4I3Z
3
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
248
Blastp_CBE
39.93
33%
-8
- C1 -
-
1P5E
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
195
Blastp_CBE
39.93
33%
-9
- C1 -
-
3MY5
3
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
249
Blastp_CBE
39.92
33%
-7
- C1 -
-
1GY3
2
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
213
Blastp_CBE
39.90
33%
-9
- C1 -
-
4CFW
1
CDK2_HUMAN
C:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
272
Blastp_CBE
39.87
33%
-7
- C1 -
-
1JST
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
209
Blastp_CBE
39.87
33%
-4
- C1 -
-
5CYI
1
CDK2_HUMAN
C:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
168
Blastp_CBE
39.86
33%
-6
- C1 -
-
1OGU
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
219
Blastp_CBE
39.85
33%
-9
- C1 -
-
1H1S
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
263
Blastp_CBE
39.82
33%
-7
- C1 -
-
2UZD
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
260
Blastp_CBE
39.82
33%
-7
- C1 -
-
2UZL
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
197
Blastp_CBE
39.80
33%
-6
- C1 -
-
3BHV
2
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
212
Blastp_CBE
39.78
33%
-7
- C1 -
-
4CFX
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
242
Blastp_CBE
39.79
33%
-7
- C1 -
-
2CCI
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
199
Blastp_CBE
39.78
33%
-5
- C1 -
-
3BHU
1
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
246
Blastp_CBE
39.77
33%
-3
- C1 -
-
1QMZ
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
232
Blastp_CBE
39.71
33%
-2
- C1 -
-
5L2W
2
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
274
Blastp_CBE
39.70
33%
-10
- C1 -
-
1FQ1
1
CDK2_HUMAN
B:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
237
Blastp_CBE
39.66
33%
-7
- C1 -
-
3DDP
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
204
Blastp_CBE
39.64
33%
-5
- C1 -
-
1PKD
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
270
Blastp_CBE
39.63
33%
-2
- C1 -
-
2C6T
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
188
Blastp_CBE
39.58
33%
-6
- C1 -
-
4BCN
1
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
172
Blastp_CBE
39.58
34%
-8
- C1 -
-
4CFU
1
CDK2_HUMAN
A:
[2-297]
-----------------------------------------------
P
P
G
S
M
E
-
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
264
Blastp_CBE
39.57
33%
-7
- C1 -
-
2UZD
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
161
Blastp_CBE
39.52
33%
-6
- C1 -
-
1OIY
1
CDK2_HUMAN
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
225
Blastp_CBE
39.50
33%
-5
- C1 -
-
1H1P
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
273
Blastp_CBE
39.47
33%
-9
- C1 -
-
1JST
1
CDK2_HUMAN
A:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
259
Blastp_CBE
39.49
33%
-7
- C1 -
-
2UZL
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
216
Blastp_CBE
39.48
33%
-5
- C1 -
-
4CFM
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
193
Blastp_CBE
39.47
33%
-10
- C1 -
-
3TNW
1
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
222
Blastp_CBE
39.46
33%
-9
- C1 -
-
1H1Q
1
CDK2_HUMAN
C:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
173
Blastp_CBE
39.42
33%
-25
- C1 -
-
4EOQ
1
CDK2_HUMAN
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
152
Blastp_CBE
39.37
33%
0
- C1 -
-
6GUF
1
CDK2_HUMAN
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
224
Blastp_CBE
39.35
33%
-0
- C1 -
-
1H1P
1
CDK2_HUMAN
C:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
234
Blastp_CBE
39.34
33%
-3
- C1 -
-
3DOG
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
---------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
247
Blastp_CBE
39.29
33%
-6
- C1 -
-
1P5E
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
181
Blastp_CBE
39.26
33%
-4
- C1 -
-
4EOS
1
CDK2_HUMAN
C:
[6-295]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
166
Blastp_CBE
39.23
33%
-4
- C1 -
-
1OI9
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
---------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
241
Blastp_CBE
39.12
33%
-7
- C1 -
-
2CCI
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
211
Blastp_CBE
39.10
33%
-4
- C1 -
-
4CFX
1
CDK2_HUMAN
C:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
189
Blastp_CBE
39.05
33%
-6
- C1 -
-
4BCN
1
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
178
Blastp_CBE
39.02
33%
-9
- C1 -
-
4BCM
1
CDK2_HUMAN
A:
[6-295]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
243
Blastp_CBE
39.01
33%
-4
- C1 -
-
2CCH
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
191
Blastp_CBE
38.98
33%
-5
- C1 -
-
4BCK
2
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
214
Blastp_CBE
38.97
33%
-6
- C1 -
-
4CFW
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
250
Blastp_CBE
38.95
33%
-3
- C1 -
-
1GY3
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
162
Blastp_CBE
38.95
33%
-7
- C1 -
-
1OIY
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
205
Blastp_CBE
38.92
33%
-6
- C1 -
-
1E9H
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
221
Blastp_CBE
38.91
33%
-4
- C1 -
-
1H1R
1
CDK2_HUMAN
A:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
177
Blastp_CBE
38.90
33%
-8
- C1 -
-
4BCM
1
CDK2_HUMAN
C:
[6-295]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
160
Blastp_CBE
38.90
33%
-4
- C1 -
-
4CFN
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
231
Blastp_CBE
38.87
33%
-6
- C1 -
-
5LMK
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
190
Blastp_CBE
38.87
33%
-9
- C1 -
-
4BCK
1
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
174
Blastp_CBE
38.85
33%
-6
- C1 -
-
4EOQ
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
187
Blastp_CBE
38.84
33%
-1
- C1 -
-
4BCO
1
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
244
Blastp_CBE
38.82
33%
-4
- C1 -
-
2CCH
3
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
196
Blastp_CBE
38.82
33%
-19
- C1 -
-
3BHV
1
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
158
Blastp_CBE
38.79
33%
-6
- C1 -
-
6GUB
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
171
Blastp_CBE
38.77
34%
-15
- C1 -
-
4CFU
1
CDK2_HUMAN
C:
[3-297]
------------------------------------------------
P
G
S
M
E
-
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
185
Blastp_CBE
38.75
33%
-2
- C1 -
-
4BCP
1
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
182
Blastp_CBE
38.72
33%
-6
- C1 -
-
4EOS
1
CDK2_HUMAN
A:
[6-295]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
-----------------
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
201
Blastp_CBE
38.65
33%
-7
- C1 -
-
3BHT
1
CDK2_HUMAN
A:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
164
Blastp_CBE
38.61
33%
-3
- C1 -
-
1OIU
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
175
Blastp_CBE
38.50
33%
-5
- C1 -
-
4BCQ
1
CDK2_HUMAN
C:
[6-295]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
236
Blastp_CBE
38.48
33%
-3
- C1 -
-
3DDQ
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
151
Blastp_CBE
38.47
33%
-4
- C1 -
-
6GUE
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
---------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
N
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
153
Blastp_CBE
38.39
33%
-4
- C1 -
-
6GUF
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
-----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
203
Blastp_CBE
38.35
33%
-6
- C1 -
-
1PKD
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
157
Blastp_CBE
38.33
33%
-4
- C1 -
-
6GUB
1
?
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
-----
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
230
Blastp_CBE
38.31
33%
-2
- C1 -
-
6GVA
3
CDK2_HUMAN
A:
[4-291]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
----------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
---------------------------------------------------------------------------
176
Blastp_CBE
38.31
33%
-9
- C1 -
-
4BCQ
1
CDK2_HUMAN
A:
[6-295]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
239
Blastp_CBE
38.28
33%
-22
- C1 -
-
2G9X
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-------------------------------------
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
261
Blastp_CBE
38.13
33%
-3
- C1 -
-
2UZE
1
CDK2_HUMAN
C:
[3-292]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
184
Blastp_CBE
38.12
33%
-15
- C1 -
-
4BCP
1
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
192
Blastp_CBE
38.06
33%
-4
- C1 -
-
3TNW
1
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
156
Blastp_CBE
37.97
33%
-7
- C1 -
-
6GUC
1
CDK2_HUMAN
A:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
---------------------
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
167
Blastp_CBE
37.94
33%
-14
- C1 -
-
1OGU
1
CDK2_HUMAN
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
200
Blastp_CBE
37.82
33%
-14
- C1 -
-
3BHT
1
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
198
Blastp_CBE
37.66
33%
-12
- C1 -
-
3BHU
1
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
186
Blastp_CBE
37.60
33%
-18
- C1 -
-
4BCO
1
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------------------------------------
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
154
Blastp_CBE
37.56
33%
1
- C1 -
-
6GUE
1
CDK2_HUMAN
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
---------
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
---
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
180
Blastp_CBE
37.36
33%
-4
- C1 -
-
4EOR
1
CDK2_HUMAN
A:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
------------------
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
----
V
W
P
G
V
T
S
-
M
P
D
Y
---
K
PS-
F
P
K
W
A
R
Q
D
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
202
Blastp_CBE
36.94
33%
-18
- C1 -
-
5LMK
1
?
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------------------
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
179
Blastp_CBE
36.83
33%
-21
- C1 -
-
4EOR
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-------------------------------------
F
S
K
V
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
163
Blastp_CBE
36.83
33%
-17
- C1 -
-
1OIU
1
CDK2_HUMAN
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------------------
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
233
Blastp_CBE
36.74
33%
-13
- C1 -
-
3DOG
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
--------------------------------------------
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
146
Blastp_CBE
36.58
34%
-16
- C1 -
-
2IW8
1
CDK2_HUMAN
C:
[7-296]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------------------
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
235
Blastp_CBE
36.52
33%
-14
- C1 -
-
3DDQ
1
CDK2_HUMAN
C:
[4-293]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------------------
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
169
Blastp_CBE
36.31
34%
-19
- C1 -
-
4CFV
1
CDK2_HUMAN
C:
[5-297]
--------------------------------------------------
S
M
E
-
N
------------
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
--------------------------------------------
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
194
Blastp_CBE
36.30
33%
-18
- C1 -
-
3MY5
1
CDK2_HUMAN
C:
[5-294]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------------------
V
-
P
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
215
Blastp_CBE
35.98
33%
-10
- C1 -
-
4CFM
1
CDK2_HUMAN
C:
[8-297]
------------------------------------------------------
N
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
--
R
L
D
--------
T
------
E
T
E
G
VPSTAI
R
---
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
---
G
V
P
-----
V
-------
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--------------------------------------------
P
L
D
---
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
-
* C *
-
-
:
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------