@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : IGF1R_HUMAN: (2021-11-22 )
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
Atome Classification :
(385 SA)
.........10........20........30........40........50........60.....--.--..70........80........90.........--100.......110.......120.......130.......140.......150.......160.......170.-...-....180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280....-...290-..-..---....300.......310.......320.......330.....-..340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......-440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.....-----..-----560---.........570.......580.......590.......600.......610.......620.......630.......640.......650.......660....-...670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810....-...820.......830.......840.......850.......860.......870...-...-.880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.....-----...990-........1000......1010......1020-....--..1030...-...1040...-...1050......1060.......----1070-----..-....1080......1090...------.-.----.-----1100....---------..--1110......1120......1130......1140---.-....----.1150.....-.1160....-..1170......1180......1190......1200......1210....-..1220......1230......1240......1250......1260--.......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKSGSGGGS
P
T
S
L
W
G
L
L
F
L
S
A
A
L
SLWPTSGEICGPGIDI
R
N
D
Y
Q
Q
L
K
R
LEN
C
T
V
I
E
G
Y
L
H
I
L
L
I
SK--A--
E
D
YRSYRF
P
K
L
T
V
I
T
E
Y
L
L
L
F
R
V
-
A
G
L
E
S
L
G
D
L--FPN
L
T
V
I
RG
W
K
L
F
Y
N
Y
A
L
V
I
F
E
MTNLKDIG
L
Y
N
L
R
N
ITR
G
A
I
R
I
EKNA
D
L
C
Y
L
STV
D
W
S
L
I
L
D
A
VSNN
Y
I
VG-N-K
P
P
-
K
E
C
GDLCPGTMEEKPMCEKTTINNEY
N
Y
R
C
WTT
N
R
C
Q
K
M
C
P
S
T
CGKRACTENNECC
H
P
E
C
LGSCSAPDND
T
A
C
V
A
C
R
H
Y
Y
Y
A
G
V
CVPACPPNTYRFE
G
W
R
C
V
D
R
D
F
C
A
N
I
L
-SAESS--DS-E
G
---
F
V
I
HD
G
E
C
M
Q
ECP
S
G
F
IRNGSQ
S
M
Y
C
I
PCEGP
C
P
K
V
C
E
E
E
KK-TK
T
I
D
S
V
T
S
A
Q
M
LQG
C
T
I
FKG
N
L
L
I
N
I
RRGN
N
I
A
S
E
L
E
N
F
M
G
L
I
E
V
V
T
G
Y
V
K
I
RHSHA
L
V
S
L
S
F
L
K
N
L
R
L
I
L
G
E
E
QLEGN
Y
S
F
Y
V
LDNQ
N
L
Q
Q
L
WDWDHR
N
L
-
T
I
K
A
G
K
M
Y
F
AFN
P
K
L
C
V
S
E
I
Y
R
M
E
E
VTGTKGRQSKGDINTRNNGERASCES
D
V
L
H
F
TSTTTSK
N
R
I
I
I
T
W
HRYRPP
D
Y
R
D
L
I
S
F
T
V
Y
Y
KEAPFKNVTEYDGQDACGSNSW
N
M
V
D
VDLP-----PN-----K-----DVEPG
I
L
L
HGLKPW
T
Q
Y
A
V
Y
V
K
A
V
T
L
T
M
VENDHIRGAK
S
E
I
L
Y
I
RTNASVPSI
P
L
D
VLSASNSS
S
Q
L
I
V
K
WNPPSLPNGN
L
S
Y
Y
I
V
R
W
Q
RQPQDG
Y
L
Y
RHNYCSKD-KIP
I
R
KYADG
T
I
D
I
E
E
VTENPKTEVCGGEKGPCCACPK
T
E
A
E
K
Q
A
E
K
E
E
A
E
Y
R
K
V
F
E
N
F
L
HNSIFVPR
P
E
R
K
R
R
D
V
M
Q
V
A
N
T
T
MSSRSRNTTAADTYNIT
D
P
E
E
LETEYP
F
F
E
S
RVDN
K
E
R
T
V
I
SNLR
P
F
T
L
Y
R
I
D
IHSCN
H
E
A
E
KLGCS-AS
N
F
V
F
A
RTMPAEGADDIPGPVTWEPRPEN
S
I
F
L
KWPEPENPN
G
L
I
L
M
Y
E
IKYGS
Q
V
E
D
-
Q
R
E
-
C
V
S
R
Q
E
Y
R
K
YGGAKLNRLNPG
N
Y
T
A
R
I
Q
A
T
S
LSGNGSWT
D
P
V
F
F
Y
V
Q
AKT
G
Y
E
N
F
I
H
L
I
I
A
L
P
V
A
V
L
L
I
V
G
G
L
V
I
M
L
Y
V
F
H
RKRNNSRLGN
G
V
L
Y
A
SVNPEY-FSAADV-----YVPD
E
--
W
E
V
A
R
E
K
I
T
M
S
RELGQGS
F
G
M
V
Y
E
G
V
AKGVVK-DEPE--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
EF
N
C
H
-
H
V
V
R
L
L
G
V
V----SQGQ-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
LRP------E-M----E-----NNPVLAPP---------
S
L
--
S
K
M
I
Q
M
A
G
E
IADG
M
A
Y
LNA
N
K
F
V
H
R
D
L
A
ARN
C
M
V---A-E
D
F
T
----
V
K
IGDFGMT
R
-
D
I
Y
E
T
D
Y
YR-KGGKGL
L
P
V
R
WM
S
P
E
S
LKDGV
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
EQPYQGL
S
-
N
E
Q
V
L
R
F
V
M
EGGLLDKPDN
C
P
D
M
L
F
E
L
M
R
M
C
WQYNPKM
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
MEPGF
R
E
V
S
F
Y
YSEENKLPE
P
E
ELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGP
G
V
L
V
L
RASFDERQPYAHMNGGRKNERALPLPQSSTC
573
HHSearch
82.65
99%
-111
- C1 -
-
5U8R
10
IGF1R_HUMAN
A:
[1-876]
------------------------------
E
I
C
G
P
G
I
D
I
R
N
D
Y
Q
Q
L
K
R
L
E
N
C
T
V
I
E
G
Y
L
H
I
L
L
I
S
K
--
A
-----
R
S
Y
R
F
P
K
L
T
V
I
T
E
Y
L
L
L
F
R
V
-
A
G
L
E
S
L
G
D
L
--
F
P
N
L
T
V
I
R
G
W
K
L
F
Y
N
Y
A
L
V
I
F
E
M
T
N
L
K
D
I
G
L
Y
N
L
R
N
I
T
R
G
A
I
R
I
E
K
N
A
D
L
C
Y
L
S
T
V
D
W
S
L
I
L
D
A
V
S
N
N
Y
I
V
G
-
N
-
K
P
P
-
K
E
C
G
D
L
C
P
G
-------
C
E
K
T
T
I
N
N
E
Y
N
Y
R
C
W
T
T
N
R
C
Q
K
M
C
P
S
T
C
G
K
R
A
C
T
E
N
N
E
C
C
H
P
E
C
L
G
S
C
S
A
P
D
N
D
T
A
C
V
A
C
R
H
Y
Y
Y
A
G
V
C
V
P
A
C
P
P
N
T
Y
R
F
E
G
W
R
C
V
D
R
D
F
C
A
N
I
L
-
S
A
E
S
S
--
D
S
-
E
G
---
F
V
I
H
D
G
E
C
M
Q
E
C
P
S
G
F
I
R
N
G
S
Q
S
M
Y
C
I
P
C
E
G
P
C
P
K
V
C
E
E
E
K
K
-
T
K
T
I
D
S
V
T
S
A
Q
M
L
Q
G
C
T
I
F
K
G
N
L
L
I
N
I
R
R
G
N
N
I
A
S
E
L
E
N
F
M
G
L
I
E
V
V
T
G
Y
V
K
I
R
H
S
H
A
L
V
S
L
S
F
L
K
N
L
R
L
I
L
G
E
E
Q
L
E
G
N
Y
S
F
Y
V
L
D
N
Q
N
L
Q
Q
L
W
D
W
D
H
R
N
L
-
T
I
K
A
G
K
M
Y
F
A
F
N
P
K
L
C
V
S
E
I
Y
R
M
E
E
V
T
G
T
K
G
R
Q
S
K
G
D
I
N
T
R
N
N
G
E
R
A
S
C
E
S
D
V
L
H
F
T
S
T
T
T
S
K
N
R
I
I
I
T
W
H
R
Y
R
P
P
D
Y
R
D
L
I
S
F
T
V
Y
Y
K
E
A
P
F
K
N
V
T
E
Y
--------
N
S
W
N
M
V
D
V
D
L
P
-----
P
N
-----
K
-----
D
V
E
P
G
I
L
L
H
G
L
K
P
W
T
Q
Y
A
V
Y
V
K
A
V
T
L
T
M
V
E
N
D
H
I
R
G
A
K
S
E
I
L
Y
I
R
T
N
A
S
V
P
S
I
P
L
D
V
L
S
A
S
N
S
S
S
Q
L
I
V
K
W
N
P
P
S
L
P
N
G
N
L
S
Y
Y
I
V
R
W
Q
R
Q
P
Q
D
G
Y
L
Y
R
H
N
Y
C
S
K
D
-
K
I
P
I
R
K
---------------------------------------
E
K
E
E
A
E
Y
R
K
V
F
E
N
F
L
H
N
S
I
F
V
P
R
---------------------------------------
E
Y
P
F
F
E
S
R
V
D
N
K
E
R
T
V
I
S
N
L
R
P
F
T
L
Y
R
I
D
I
H
S
C
N
H
E
A
E
K
L
G
C
S
-
A
S
N
F
V
F
A
R
T
M
P
A
E
G
A
D
D
I
P
G
P
V
T
W
E
P
R
P
E
N
S
I
F
L
K
W
P
E
P
E
N
P
N
G
L
I
L
M
Y
E
I
K
Y
G
S
Q
V
E
D
-
Q
R
E
-
C
V
S
R
Q
E
Y
R
K
Y
G
G
A
K
L
N
R
L
N
P
G
N
Y
T
A
R
I
Q
A
T
S
L
S
G
N
G
S
W
T
D
P
V
F
F
Y
V
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.22
97%
-111
- C1 -
-
5U8R
10
IGF1R_HUMAN
A:
[1-877]
------------------------------
E
I
C
G
P
G
I
D
I
R
N
D
Y
Q
Q
L
K
R
L
E
N
C
T
V
I
E
G
Y
L
H
I
L
L
I
S
K
--
A
-----
R
S
Y
R
F
P
K
L
T
V
I
T
E
Y
L
L
L
F
R
V
-
A
G
L
E
S
L
G
D
L
--
F
P
N
L
T
V
I
R
G
W
K
L
F
Y
N
Y
A
L
V
I
F
E
M
T
N
L
K
D
I
G
L
Y
N
L
R
N
I
T
R
G
A
I
R
I
E
K
N
A
D
L
C
Y
L
S
T
V
D
W
S
L
I
L
D
A
V
S
N
N
Y
I
V
G
-
N
-
K
P
P
-
K
E
C
G
D
L
C
P
G
-------
C
E
K
T
T
I
N
N
E
Y
N
Y
R
C
W
T
T
N
R
C
Q
K
M
C
P
S
T
C
G
K
R
A
C
T
E
N
N
E
C
C
H
P
E
C
L
G
S
C
S
A
P
D
N
D
T
A
C
V
A
C
R
H
Y
Y
Y
A
G
V
C
V
P
A
C
P
P
N
T
Y
R
F
E
G
W
R
C
V
D
R
D
F
C
A
N
I
L
-
S
A
E
S
S
--
D
S
-
E
G
---
F
V
I
H
D
G
E
C
M
Q
E
C
P
S
G
F
I
R
N
G
S
Q
S
M
Y
C
I
P
C
E
G
P
C
P
K
V
C
E
E
E
K
K
-
T
K
T
I
D
S
V
T
S
A
Q
M
L
Q
G
C
T
I
F
K
G
N
L
L
I
N
I
R
R
G
N
N
I
A
S
E
L
E
N
F
M
G
L
I
E
V
V
T
G
Y
V
K
I
R
H
S
H
A
L
V
S
L
S
F
L
K
N
L
R
L
I
L
G
E
E
Q
L
E
G
N
Y
S
F
Y
V
L
D
N
Q
N
L
Q
Q
L
W
D
W
D
H
R
N
L
-
T
I
K
A
G
K
M
Y
F
A
F
N
P
K
L
C
V
S
E
I
Y
R
M
E
E
V
T
G
T
K
G
R
Q
S
K
G
D
I
N
T
R
N
N
G
E
R
A
S
C
E
S
D
V
L
H
F
T
S
T
T
T
S
K
N
R
I
I
I
T
W
H
R
Y
R
P
P
D
Y
R
D
L
I
S
F
T
V
Y
Y
K
E
A
P
F
K
N
V
T
E
Y
--------
N
S
W
N
M
V
D
V
D
L
P
-----
P
N
-----
K
-----
D
V
E
P
G
I
L
L
H
G
L
K
P
W
T
Q
Y
A
V
Y
V
K
A
V
T
L
T
M
V
E
N
D
H
I
R
G
A
K
S
E
I
L
Y
I
R
T
N
A
S
V
P
S
I
P
L
D
V
L
S
A
S
N
S
S
S
Q
L
I
V
K
W
N
P
P
S
L
P
N
G
N
L
S
Y
Y
I
V
R
W
Q
R
Q
P
Q
D
G
Y
L
Y
R
H
N
Y
C
S
K
D
-
K
I
P
I
R
K
---------------------------------------
E
K
E
E
A
E
Y
R
K
V
F
E
N
F
L
H
N
S
I
F
V
P
R
---------------------------------------
E
Y
P
F
F
E
S
R
V
D
N
K
E
R
T
V
I
S
N
L
R
P
F
T
L
Y
R
I
D
I
H
S
C
N
H
E
A
E
K
L
G
C
S
-
A
S
N
F
V
F
A
R
T
M
P
A
E
G
A
D
D
I
P
G
P
V
T
W
E
P
R
P
E
N
S
I
F
L
K
W
P
E
P
E
N
P
N
G
L
I
L
M
Y
E
I
K
Y
G
S
Q
V
E
D
-
Q
R
E
-
C
V
S
R
Q
E
Y
R
K
Y
G
G
A
K
L
N
R
L
N
P
G
N
Y
T
A
R
I
Q
A
T
S
L
S
G
N
G
S
W
T
D
P
V
F
F
Y
V
Q
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
81.14
97%
-107
* C4 *
-
5U8Q
9
IGF1R_HUMAN
A:
[1-880]
------------------------------
E
I
C
G
P
G
I
D
I
R
N
D
Y
Q
Q
L
K
R
L
E
N
C
T
V
I
E
G
Y
L
H
I
L
L
I
S
---------
R
S
Y
R
F
P
K
L
T
V
I
T
E
Y
L
L
L
F
R
V
-
A
G
L
E
S
L
G
D
L
--
F
P
N
L
T
V
I
R
G
W
K
L
F
Y
N
Y
A
L
V
I
F
E
M
T
N
L
K
D
I
G
L
Y
N
L
R
N
I
T
R
G
A
I
R
I
E
K
N
A
D
L
C
Y
L
S
T
V
D
W
S
L
I
L
D
A
V
S
N
N
Y
I
V
G
-
N
-
K
P
P
-
K
E
C
G
D
L
C
P
--------
C
E
K
T
T
I
N
N
E
Y
N
Y
R
C
W
T
T
N
R
C
Q
K
M
C
P
S
T
C
---
A
C
T
E
N
N
E
C
C
H
P
E
C
L
G
S
C
S
A
P
D
N
D
T
A
C
V
A
C
R
H
Y
Y
Y
A
G
V
C
V
P
A
C
P
P
N
T
Y
R
F
E
G
W
R
C
V
D
R
D
F
C
A
N
I
L
-
S
A
E
S
S
--
D
S
-
E
G
---
F
V
I
H
D
G
E
C
M
Q
E
C
P
S
G
F
I
R
N
G
S
Q
S
M
Y
C
I
P
C
E
G
P
C
P
K
V
C
E
E
E
K
K
-
T
K
T
I
D
S
V
T
S
A
Q
M
L
Q
G
C
T
I
F
K
G
N
L
L
I
N
I
R
R
G
N
N
I
A
S
E
L
E
N
F
M
G
L
I
E
V
V
T
G
Y
V
K
I
R
H
S
H
A
L
V
S
L
S
F
L
K
N
L
R
L
I
L
G
E
E
Q
L
E
G
N
Y
S
F
Y
V
L
D
N
Q
N
L
Q
Q
L
W
D
W
D
H
R
N
L
-
T
I
K
A
G
K
M
Y
F
A
F
N
P
K
L
C
V
S
E
I
Y
R
M
E
E
V
T
G
T
K
G
R
Q
S
K
G
D
I
N
T
R
N
N
G
E
R
A
S
C
E
S
D
V
L
H
F
T
S
T
T
T
S
K
N
R
I
I
I
T
W
H
R
Y
R
P
P
D
Y
R
D
L
I
S
F
T
V
Y
Y
K
E
A
P
F
K
N
V
T
E
Y
D
G
Q
D
A
C
G
S
N
S
W
N
M
V
D
V
D
L
P
-----
P
N
-----
K
-----
D
V
E
P
G
I
L
L
H
G
L
K
P
W
T
Q
Y
A
V
Y
V
K
A
V
T
L
T
M
V
E
N
D
H
I
R
G
A
K
S
E
I
L
Y
I
R
T
N
A
S
V
P
S
I
P
L
D
V
L
S
A
S
N
S
S
S
Q
L
I
V
K
W
N
P
P
S
L
P
N
G
N
L
S
Y
Y
I
V
R
W
Q
R
Q
P
Q
D
G
Y
L
Y
R
H
N
Y
C
S
K
D
-
K
I
P
I
R
K
Y
A
--------------------------------------------
R
K
V
F
E
N
F
L
H
N
S
I
F
V
P
R
P
---------------------------------------
Y
P
F
F
E
S
R
V
D
N
K
E
R
T
V
I
S
N
L
R
P
F
T
L
Y
R
I
D
I
H
S
C
N
H
E
A
E
K
L
G
C
S
-
A
S
N
F
V
F
A
R
T
M
P
A
E
G
A
D
D
I
P
G
P
V
T
W
E
P
R
P
E
N
S
I
F
L
K
W
P
E
P
E
N
P
N
G
L
I
L
M
Y
E
I
K
Y
G
S
Q
V
E
D
-
Q
R
E
-
C
V
S
R
Q
E
Y
R
K
Y
G
G
A
K
L
N
R
L
N
P
G
N
Y
T
A
R
I
Q
A
T
S
L
S
G
N
G
S
W
T
D
P
V
F
F
Y
V
Q
A
K
T
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
76.57
95%
-97
- C3 -
-
6PYH
-
?
A:
[1-897]
------------------------------
E
I
C
G
P
G
I
D
I
R
N
D
Y
Q
Q
L
K
R
L
E
N
C
T
V
I
E
G
F
L
H
I
L
L
I
S
---------
R
S
Y
R
F
P
K
L
T
V
I
T
E
Y
L
L
L
F
R
V
-
A
G
L
E
S
L
G
D
L
--
F
P
N
L
T
V
I
R
G
W
K
L
F
Y
N
Y
A
L
V
I
F
E
M
T
N
L
K
D
I
G
L
Y
N
L
R
N
I
T
R
G
A
I
R
I
E
K
N
A
D
L
C
Y
L
S
T
I
D
W
S
L
I
L
D
A
V
S
N
N
Y
I
V
G
-
N
-
K
P
P
-
K
E
C
G
D
L
C
P
G
T
L
E
E
---
C
E
K
T
T
I
N
N
E
Y
N
Y
R
C
W
T
T
N
R
C
Q
K
M
C
P
S
V
C
--
R
A
C
T
E
N
N
E
C
C
H
P
E
C
L
G
S
C
H
-
P
D
D
N
T
T
C
V
A
C
R
H
Y
Y
Y
K
G
V
C
V
P
A
C
P
P
G
T
Y
R
F
E
G
W
R
C
V
D
R
D
F
C
A
N
I
P
---------
S
-
D
G
---
F
V
I
H
D
D
E
C
M
Q
E
C
P
S
G
F
I
R
N
S
T
Q
S
M
Y
C
I
P
C
E
G
P
C
P
K
V
C
--
E
K
K
-
T
K
T
I
D
S
V
T
S
A
Q
M
L
Q
G
C
T
I
L
K
G
N
L
L
I
N
I
R
R
G
N
N
I
A
S
E
L
E
N
F
M
G
L
I
E
V
V
T
G
Y
V
K
I
R
H
S
H
A
L
V
S
L
S
F
L
K
N
L
R
L
I
L
G
E
E
Q
L
E
G
N
Y
S
F
Y
V
L
D
N
Q
N
L
Q
Q
L
W
D
W
N
H
R
N
L
-
T
V
R
S
G
K
M
Y
F
A
F
N
P
K
L
C
V
S
E
I
Y
R
M
E
E
V
T
G
T
K
G
R
Q
S
K
G
D
I
N
T
R
N
N
G
E
R
A
S
C
E
S
D
V
L
R
F
T
S
T
T
T
W
K
N
R
I
I
I
T
W
H
R
Y
R
P
P
D
Y
R
D
L
I
S
F
T
V
Y
Y
K
E
A
P
F
K
N
V
T
E
Y
D
G
Q
D
A
C
G
S
N
S
W
N
M
V
D
V
D
L
P
-----
P
N
-----
K
-----
E
G
E
P
G
I
L
L
H
G
L
K
P
W
T
Q
Y
A
V
Y
V
K
A
V
T
L
T
M
V
E
N
D
H
I
R
G
A
K
S
E
I
L
Y
I
R
T
N
A
S
V
P
S
I
P
L
D
V
L
S
A
S
N
S
S
S
Q
L
I
V
K
W
N
P
P
T
L
P
N
G
N
L
S
Y
Y
I
V
R
W
Q
R
Q
P
Q
D
----------------------------------------------
C
A
C
P
K
T
E
A
E
K
Q
A
E
K
E
E
A
E
Y
R
K
V
F
E
N
F
L
H
N
S
I
F
V
P
R
P
---------------------------------------
Y
P
F
F
E
S
R
V
D
N
K
E
R
T
V
I
S
N
L
R
P
F
T
L
Y
R
I
D
I
H
S
C
N
H
E
A
E
K
L
G
C
S
-
A
S
N
F
V
F
A
R
T
M
P
A
E
G
A
D
D
I
P
G
P
V
T
W
E
P
R
P
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N
S
I
F
L
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W
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P
E
N
P
N
G
L
I
L
M
Y
E
I
K
Y
G
S
Q
V
E
D
-
Q
R
E
-
C
V
S
R
Q
E
Y
R
K
Y
G
G
A
K
L
N
R
L
N
P
G
N
Y
T
A
R
I
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A
T
S
L
S
G
N
G
S
W
T
D
P
V
F
F
Y
V
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
569
HHSearch
72.44
95%
-36
- C3 -
-
6PYH
-
?
D:
[1-897]
------------------------------
E
I
C
G
P
G
I
D
I
R
N
D
Y
Q
Q
L
K
R
L
E
N
C
T
V
I
E
G
F
L
H
I
L
L
I
S
K
--
A
--
E
D
Y
R
S
Y
R
F
P
K
L
T
V
I
T
E
Y
L
L
L
F
R
V
A
G
L
E
S
L
G
-
D
L
--
F
P
N
L
T
V
I
R
G
W
K
L
F
Y
N
Y
A
L
V
I
F
E
M
T
N
L
K
D
I
G
L
Y
N
L
R
N
I
T
R
G
A
I
R
I
E
K
N
A
D
L
C
Y
L
S
T
I
D
W
S
L
I
L
D
A
V
S
N
N
Y
I
V
G
-
N
-
K
P
P
-
K
E
C
G
D
L
C
P
--------
C
E
K
T
T
I
N
N
E
Y
N
Y
R
C
W
T
T
N
R
C
Q
K
M
C
P
S
V
C
---
A
C
T
E
N
N
E
C
C
H
P
E
C
L
G
S
C
H
T
P
D
D
N
T
T
C
V
A
C
R
H
Y
Y
Y
K
G
V
C
V
P
A
C
P
P
G
T
Y
R
F
E
G
W
R
C
V
D
R
D
F
C
A
N
I
P
-
N
A
E
S
-------
G
---
F
V
I
H
D
D
E
C
M
Q
E
C
P
S
G
F
I
R
N
S
T
Q
S
M
Y
C
I
P
C
------
V
C
G
D
E
E
K
K
T
K
T
I
D
S
V
T
S
A
Q
M
L
Q
G
C
T
I
L
K
G
N
L
L
I
N
I
R
R
G
N
N
I
A
S
E
L
E
N
F
M
G
L
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V
T
G
Y
V
K
I
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H
S
H
A
L
V
S
L
S
F
L
K
N
L
R
L
I
L
G
E
E
Q
L
E
G
N
Y
S
F
Y
V
L
D
N
Q
N
L
Q
Q
L
W
D
W
N
H
R
N
L
-
T
V
R
S
G
K
M
Y
F
A
F
N
P
K
L
C
V
S
E
I
Y
R
M
E
E
V
T
G
T
K
G
R
Q
S
K
G
D
I
N
T
R
N
N
G
E
R
A
S
C
E
S
D
V
L
R
F
T
S
T
T
T
W
K
N
R
I
I
I
T
W
H
R
Y
R
P
P
D
Y
R
D
L
I
S
F
T
V
Y
Y
K
E
A
P
F
K
N
V
T
E
Y
D
----
C
G
S
N
S
W
N
M
V
D
V
D
--------------------
E
G
E
P
G
I
L
L
H
G
L
K
P
W
T
Q
Y
A
V
Y
V
K
A
V
T
L
T
---
N
D
H
I
R
G
A
K
S
E
I
L
Y
I
R
T
N
A
S
V
P
S
I
P
L
D
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L
S
A
S
N
S
S
S
Q
L
I
V
K
W
N
P
P
T
L
P
N
G
N
L
S
Y
Y
I
V
R
W
Q
R
Q
P
Q
D
G
Y
L
Y
R
H
N
Y
C
S
K
D
-
K
I
P
I
R
K
Y
A
-------------------------
C
A
C
P
K
T
E
A
E
K
Q
A
E
K
E
E
A
E
Y
R
K
V
F
E
N
F
L
H
N
S
I
F
V
P
-----------------------------------------
Y
P
F
F
E
S
R
V
D
N
K
E
R
T
V
I
S
N
L
R
P
F
T
L
Y
R
I
D
I
H
S
C
N
H
E
A
E
K
L
G
C
S
-
A
S
N
F
V
F
A
R
T
M
P
A
E
G
A
D
D
I
P
G
P
V
T
W
E
P
R
P
E
N
S
I
F
L
K
W
P
E
P
E
N
P
N
G
L
I
L
M
Y
E
I
K
Y
G
S
Q
V
E
D
-
Q
R
E
-
C
V
S
R
Q
E
Y
R
K
Y
G
G
A
K
L
N
R
L
N
P
G
N
Y
T
A
R
I
Q
A
T
S
L
S
G
N
G
S
W
T
D
P
V
F
F
Y
V
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.34
57%
7
- C3 -
-
6PXV
-
?
A:
[2-910]
------------------------
L
Y
P
--
G
E
V
C
-
P
G
M
D
I
R
N
N
L
T
R
L
H
E
L
E
N
C
S
V
I
E
G
H
L
Q
I
L
L
M
F
K
--
T
RP
E
D
F
R
D
L
S
F
P
K
L
I
M
I
T
D
Y
L
L
L
F
R
V
-
Y
G
L
E
S
L
K
D
L
--
F
P
N
L
T
V
I
R
G
S
R
L
F
F
N
Y
A
L
V
I
F
E
M
V
H
L
K
E
L
G
L
Y
N
L
M
N
I
T
R
G
S
V
R
I
E
K
N
N
E
L
C
Y
L
A
T
I
D
W
S
R
I
L
D
S
V
E
D
N
Y
I
V
L
-
N
-
K
D
D
N
E
E
C
G
D
I
C
P
G
-----
T
N
C
P
A
T
V
I
N
G
Q
F
V
E
R
C
W
T
H
S
H
C
Q
K
V
C
P
T
I
C
K
S
H
G
C
T
A
E
G
L
C
C
H
S
E
C
L
G
N
C
S
Q
P
D
D
P
T
K
C
V
A
C
R
N
F
Y
L
D
G
R
C
V
E
T
C
P
P
P
Y
Y
H
F
Q
D
W
R
C
V
N
F
S
F
C
Q
D
L
H
H
K
C
K
N
S
--
R
----CHQ
Y
V
I
H
N
N
K
C
I
P
E
C
P
S
G
Y
T
M
N
S
S
-
N
L
L
C
T
P
C
L
G
P
C
P
K
V
C
H
L
L
E
G
-
E
K
T
I
D
S
V
T
S
A
Q
E
L
R
G
C
T
V
I
N
G
S
L
I
I
N
I
R
G
G
N
N
L
A
A
E
L
E
A
N
L
G
L
I
E
E
I
S
G
Y
L
K
I
R
R
S
Y
A
L
V
S
L
S
F
F
R
K
L
R
L
I
R
G
E
T
L
E
I
G
N
Y
S
F
Y
A
L
D
N
Q
N
L
R
Q
L
W
D
W
S
K
H
N
L
-
T
I
T
Q
G
K
L
F
F
H
Y
N
P
K
L
C
L
S
E
I
H
K
M
E
E
V
S
G
T
K
G
R
Q
E
R
N
D
I
A
L
K
T
N
G
D
Q
A
S
C
E
N
E
L
L
K
F
S
Y
I
R
T
S
F
D
K
I
L
L
R
W
E
P
Y
W
P
P
D
F
R
D
L
L
G
F
M
L
F
Y
K
E
A
P
Y
Q
N
V
T
E
F
---------
S
W
T
V
V
D
I
D
P
P
LRSND
P
K
-----
S
-----
Q
N
H
P
G
W
L
M
R
G
L
K
P
W
T
Q
Y
A
I
F
V
K
T
L
-
V
T
F
S
D
E
R
R
T
Y
G
A
K
S
D
I
I
Y
V
Q
T
D
A
T
N
P
S
V
P
L
D
P
I
S
V
S
N
S
S
S
Q
I
I
L
K
W
K
P
P
S
D
P
N
G
N
I
T
H
Y
L
V
F
W
E
R
Q
A
E
D
S
E
L
F
E
L
D
Y
C
L
K
G
L
K
L
P
S
R
------------------------------------
Q
I
L
K
E
L
E
E
S
S
F
R
K
T
F
E
D
Y
L
H
N
V
V
F
V
P
R
-------------------------------------
E
E
H
R
P
F
--
E
K
V
V
N
K
E
S
L
V
I
S
G
L
R
H
F
T
G
Y
R
I
E
L
Q
A
C
N
Q
D
T
P
E
E
R
C
S
-
V
A
A
Y
V
S
A
R
T
M
P
E
A
K
A
D
D
I
V
G
P
V
T
H
E
I
F
E
N
N
V
V
H
L
M
W
Q
E
P
K
E
P
N
G
L
I
V
L
Y
E
V
S
Y
R
R
Y
G
D
E
-
E
L
H
L
C
V
S
R
K
H
F
A
L
E
R
G
C
R
L
R
G
L
S
P
G
N
Y
S
V
R
I
R
A
T
S
L
A
G
N
G
S
W
T
E
P
T
Y
F
Y
V
T
D
Y
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
59.33
52%
3
- C3 -
-
4ZXB
14
?
E:
[2-882]
------------------------
L
Y
P
--
G
E
V
C
-
P
G
M
D
I
R
N
N
L
T
R
L
H
E
L
E
N
C
S
V
I
E
G
H
L
Q
I
L
L
M
F
K
--
T
RP
E
D
F
R
D
L
S
F
P
K
L
I
M
I
T
D
Y
L
L
L
F
R
V
-
Y
G
L
E
S
L
K
D
L
--
F
P
N
L
T
V
I
R
G
S
R
L
F
F
N
Y
A
L
V
I
F
E
M
V
H
L
K
E
L
G
L
Y
N
L
M
N
I
T
R
G
S
V
R
I
E
K
N
N
E
L
C
Y
L
A
T
I
D
W
S
R
I
L
D
S
V
E
D
N
H
I
V
L
-
N
-
K
D
D
N
E
E
C
G
D
I
C
P
G
-----
T
N
C
P
A
T
----
Q
F
V
E
R
C
W
T
H
S
H
C
Q
K
V
C
P
T
I
C
K
S
H
G
C
T
A
E
G
L
C
C
H
S
E
C
L
G
N
C
S
Q
P
D
D
P
T
K
C
V
A
C
R
N
F
Y
L
D
G
R
C
V
E
T
C
P
P
P
Y
Y
H
F
Q
D
W
R
C
V
N
F
S
F
C
Q
D
L
H
H
K
C
K
---------CHQ
Y
V
I
H
N
N
K
C
I
P
E
C
P
S
G
Y
T
M
N
S
S
-
N
L
L
C
T
P
C
L
G
P
C
P
K
V
C
H
L
L
E
G
-
E
K
T
I
D
S
V
T
S
A
Q
E
L
R
G
C
T
V
I
N
G
S
L
I
I
N
I
R
G
G
N
N
L
A
A
E
L
E
A
N
L
G
L
I
E
E
I
S
G
Y
L
K
I
R
R
S
Y
A
L
V
S
L
S
F
F
R
K
L
R
L
I
R
G
E
T
L
E
I
G
N
Y
S
F
Y
A
L
D
N
Q
N
L
R
Q
L
W
D
W
S
K
H
N
L
-
T
I
T
Q
G
K
L
F
F
H
Y
N
P
K
L
C
L
S
E
I
H
K
M
E
E
V
S
G
T
K
G
R
Q
E
R
N
D
I
A
L
K
T
N
G
D
Q
A
S
C
E
N
E
L
L
K
F
S
Y
I
R
T
S
F
D
K
I
L
L
R
W
E
P
Y
W
P
P
D
F
R
D
L
L
G
F
M
L
F
Y
K
E
A
P
Y
Q
N
V
---------------
V
V
D
I
D
P
P
LRSND
P
K
-----
S
-----
Q
N
H
P
G
W
L
M
R
G
L
K
P
W
T
Q
Y
A
I
F
V
K
T
L
-
V
T
F
S
D
E
R
R
T
Y
G
A
K
S
D
I
I
Y
V
Q
T
D
A
T
N
P
S
V
P
L
D
P
I
S
V
S
N
S
S
S
Q
I
I
L
K
W
K
P
P
S
D
P
N
G
N
I
T
H
Y
L
V
F
W
E
R
Q
A
E
D
S
E
L
F
E
L
D
Y
C
L
K
G
L
K
L
P
S
R
---------------------------------------
K
E
L
E
E
S
S
F
R
K
T
F
E
D
Y
L
H
-----------------------------------------
E
E
---
H
R
P
F
--
E
K
V
V
N
K
E
S
L
V
I
S
G
L
R
H
F
T
G
Y
R
I
E
L
Q
A
C
N
Q
D
T
P
E
E
R
C
S
-
V
A
A
Y
V
S
A
R
T
M
P
E
A
K
A
D
D
I
V
G
P
V
T
H
E
I
F
E
N
N
V
V
H
L
M
W
Q
E
P
K
E
P
N
G
L
I
V
L
Y
E
V
S
Y
R
R
Y
G
D
E
-
E
L
H
L
C
V
S
R
K
H
F
A
L
E
R
G
C
R
L
R
G
L
S
P
G
N
Y
S
V
R
I
R
A
T
S
L
A
G
N
G
S
W
T
E
P
T
Y
F
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
574
HHSearch
59.28
54%
4
- C1 -
-
4ZXB
14
?
E:
[4-883]
-----------------------------
P
G
E
V
C
P
G
M
D
I
R
N
N
L
T
R
L
H
E
L
E
N
C
S
V
I
E
G
H
L
Q
I
L
L
M
F
K
--
T
RP
E
D
F
R
D
L
S
F
P
K
L
I
M
I
T
D
Y
L
L
L
F
R
V
-
Y
G
L
E
S
L
K
D
L
--
F
P
N
L
T
V
I
R
G
S
R
L
F
F
N
Y
A
L
V
I
F
E
M
V
H
L
K
E
L
G
L
Y
N
L
M
N
I
T
R
G
S
V
R
I
E
K
N
N
E
L
C
Y
L
A
T
I
D
W
S
R
I
L
D
S
V
E
D
N
H
I
V
L
-
N
K
D
D
N
-
E
E
C
G
D
I
C
P
G
-----
T
N
C
P
A
T
----
Q
F
V
E
R
C
W
T
H
S
H
C
Q
K
V
C
P
T
I
C
K
S
H
G
C
T
A
E
G
L
C
C
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C
L
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C
V
A
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P
P
Y
Y
H
F
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W
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V
N
F
S
F
C
Q
D
L
H
-
H
K
C
K
-----C
H
Q
---
Y
V
I
H
N
N
K
C
I
P
E
C
P
S
G
Y
T
M
N
S
S
-
N
L
L
C
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C
L
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C
P
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V
C
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L
L
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-
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T
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G
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L
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N
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L
A
A
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L
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A
N
L
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L
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S
G
Y
L
K
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R
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L
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F
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L
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L
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L
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G
N
Y
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F
Y
A
L
D
N
Q
N
L
R
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L
W
D
W
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K
H
N
L
-
T
I
T
Q
G
K
L
F
F
H
Y
N
P
K
L
C
L
S
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K
M
E
E
V
S
G
T
K
G
R
Q
E
R
N
D
I
A
L
K
T
N
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D
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A
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C
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E
L
L
K
F
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L
L
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Y
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P
D
F
R
D
L
L
G
F
M
L
F
Y
K
E
A
P
Y
Q
N
V
---------------
V
V
D
I
D
P
P
-----
L
R
-----
S
NDPKS
Q
N
H
P
G
W
L
M
R
G
L
K
P
W
T
Q
Y
A
I
F
V
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T
L
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F
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-
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R
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Y
G
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Q
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A
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N
P
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V
P
L
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V
S
N
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S
S
Q
I
I
L
K
W
K
P
P
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P
N
G
N
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Y
L
V
F
W
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R
Q
A
E
D
S
E
L
F
E
L
D
Y
C
L
K
G
L
K
L
P
S
R
---------------------------------------
K
E
L
E
E
S
S
F
R
K
T
F
E
D
Y
L
H
---------------------------------------------
E
E
H
R
P
F
E
K
-
V
V
N
K
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S
L
V
I
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L
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-
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A
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R
Y
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L
-
C
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F
A
L
E
R
G
C
R
L
R
G
L
S
P
G
N
Y
S
V
R
I
R
A
T
S
L
A
G
N
G
S
W
T
E
P
T
Y
F
Y
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
571
HHSearch
58.50
58%
12
- C3 -
-
6PXV
-
?
A:
[5-910]
------------------------------
G
E
V
C
P
G
M
D
I
R
N
N
L
T
R
L
H
E
L
E
N
C
S
V
I
E
G
H
L
Q
I
L
L
M
F
K
TR
P
--
E
D
F
R
D
L
S
F
P
K
L
I
M
I
T
D
Y
L
L
L
F
R
V
---
Y
G
L
E
S
L
K
DL
F
P
N
L
T
V
I
R
G
S
R
L
F
F
N
Y
A
L
V
I
F
E
M
V
H
L
K
E
L
G
L
Y
N
L
M
N
I
T
R
G
S
V
R
I
E
K
N
N
E
L
C
Y
L
A
T
I
D
W
S
R
I
L
D
S
V
E
D
N
Y
I
V
L
N
K
-
D
D
N
-
E
E
C
G
D
I
C
P
G
-----
T
N
C
P
A
T
V
I
N
G
Q
F
V
E
R
C
W
T
H
S
H
C
Q
K
V
C
P
T
I
C
K
S
H
G
C
T
A
E
G
L
C
C
H
S
E
C
L
G
N
C
S
Q
P
D
D
P
T
K
C
V
A
C
R
N
F
Y
L
D
G
R
C
V
E
T
C
P
P
P
Y
Y
H
F
Q
D
W
R
C
V
N
F
S
F
C
Q
D
L
H
-
H
K
C
K
N
SR
C
--
H
Q
---
Y
V
I
H
N
N
K
C
I
P
E
C
P
S
G
Y
T
M
N
S
S
-
N
L
L
C
T
P
C
L
G
P
C
P
K
V
C
H
L
L
E
G
-
E
K
T
I
D
S
V
T
S
A
Q
E
L
R
G
C
T
V
I
N
G
S
L
I
I
N
I
R
G
G
N
N
L
A
A
E
L
E
A
N
L
G
L
I
E
E
I
S
G
Y
L
K
I
R
R
S
Y
A
L
V
S
L
S
F
F
R
K
L
R
L
I
R
G
E
T
L
E
I
G
N
Y
S
F
Y
A
L
D
N
Q
N
L
R
Q
L
W
D
-
W
S
K
H
N
L
T
I
T
Q
G
K
L
F
F
H
Y
N
P
K
L
C
L
S
E
I
H
K
M
E
E
V
S
G
T
K
G
R
Q
E
R
N
D
I
A
L
K
T
N
G
D
Q
A
S
C
E
N
E
L
L
K
F
S
Y
I
R
T
S
F
D
K
I
L
L
R
W
E
P
Y
W
P
P
D
F
R
D
L
L
G
F
M
L
F
Y
K
E
A
P
Y
Q
N
V
T
E
F
---------
S
W
T
V
V
D
I
D
P
P
-----
L
R
SNDPK
S
-----
Q
N
H
P
G
W
L
M
R
G
L
K
P
W
T
Q
Y
A
I
F
V
K
T
L
V
T
F
-
S
D
E
R
R
T
Y
G
A
K
S
D
I
I
Y
V
Q
T
D
A
T
N
P
S
V
P
L
D
P
I
S
V
S
N
S
S
S
Q
I
I
L
K
W
K
P
P
S
D
P
N
G
N
I
T
H
Y
L
V
F
W
E
R
Q
A
E
D
S
E
L
F
E
L
D
Y
C
L
K
G
-
L
K
L
P
S
R
-----------------------------------
Q
I
L
K
E
L
E
E
S
S
F
R
K
T
F
E
D
Y
L
H
N
V
V
F
V
P
R
--------------------------------------
E
E
H
R
-
P
F
E
K
V
V
N
K
E
S
L
V
I
S
G
L
R
H
F
T
G
Y
R
I
E
L
Q
A
C
N
Q
D
-
T
P
E
E
R
C
S
V
A
A
Y
V
S
A
R
T
M
P
E
A
K
A
D
D
I
V
G
P
V
T
H
E
I
F
E
N
N
V
V
H
L
M
W
Q
E
P
K
E
P
N
G
L
I
V
L
Y
E
V
S
Y
R
R
Y
G
D
E
-
E
L
H
L
C
V
S
R
K
H
F
A
L
E
R
G
C
R
L
R
G
L
S
P
G
N
Y
S
V
R
I
R
A
T
S
L
A
G
N
G
S
W
T
E
P
T
Y
F
Y
V
T
D
Y
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
579
HHSearch
52.99
100%
-138
- C1 -
-
1IGR
2
IGF1R_HUMAN
A:
[1-476]
------------------------------
E
I
C
G
P
G
I
D
I
R
N
D
Y
Q
Q
L
K
R
L
E
N
C
T
V
I
E
G
Y
L
H
I
L
L
I
S
K
--
A
--
E
D
Y
R
S
Y
R
F
P
K
L
T
V
I
T
E
Y
L
L
L
F
R
V
-
A
G
L
E
S
L
G
D
L
--
F
P
N
L
T
V
I
R
G
W
K
L
F
Y
N
Y
A
L
V
I
F
E
M
T
N
L
K
D
I
G
L
Y
N
L
R
N
I
T
R
G
A
I
R
I
E
K
N
A
D
L
C
Y
L
S
T
V
D
W
S
L
I
L
D
A
V
S
N
N
Y
I
V
G
-
N
-
K
P
P
-
K
E
C
G
D
L
C
P
G
T
M
E
E
K
P
M
C
E
K
T
T
I
N
N
E
Y
N
Y
R
C
W
T
T
N
R
C
Q
K
M
C
P
S
T
C
G
K
R
A
C
T
E
N
N
E
C
C
H
P
E
C
L
G
S
C
S
A
P
D
N
D
T
A
C
V
A
C
R
H
Y
Y
Y
A
G
V
C
V
P
A
C
P
P
N
T
Y
R
F
E
G
W
R
C
V
D
R
D
F
C
A
N
I
L
-
S
A
E
S
S
--
D
S
-
E
G
---
F
V
I
H
D
G
E
C
M
Q
E
C
P
S
G
F
I
R
N
G
S
Q
S
M
Y
C
I
P
C
E
G
P
C
P
K
V
C
E
E
E
K
K
-
T
K
T
I
D
S
V
T
S
A
Q
M
L
Q
G
C
T
I
F
K
G
N
L
L
I
N
I
R
R
G
N
N
I
A
S
E
L
E
N
F
M
G
L
I
E
V
V
T
G
Y
V
K
I
R
H
S
H
A
L
V
S
L
S
F
L
K
N
L
R
L
I
L
G
E
E
Q
L
E
G
N
Y
S
F
Y
V
L
D
N
Q
N
L
Q
Q
L
W
D
W
D
H
R
N
L
-
T
I
K
A
G
K
M
Y
F
A
F
N
P
K
L
C
V
S
E
I
Y
R
M
E
E
V
T
G
T
K
G
R
Q
S
K
G
D
I
N
T
R
N
N
G
E
R
A
S
C
E
S
D
V
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
52.93
100%
-139
- C3 -
-
1IGR
2
IGF1R_HUMAN
A:
[1-469]
------------------------------
E
I
C
G
P
G
I
D
I
R
N
D
Y
Q
Q
L
K
R
L
E
N
C
T
V
I
E
G
Y
L
H
I
L
L
I
S
K
--
A
--
E
D
Y
R
S
Y
R
F
P
K
L
T
V
I
T
E
Y
L
L
L
F
R
V
-
A
G
L
E
S
L
G
D
L
--
F
P
N
L
T
V
I
R
G
W
K
L
F
Y
N
Y
A
L
V
I
F
E
M
T
N
L
K
D
I
G
L
Y
N
L
R
N
I
T
R
G
A
I
R
I
E
K
N
A
D
L
C
Y
L
S
T
V
D
W
S
L
I
L
D
A
V
S
N
N
Y
I
V
G
-
N
-
K
P
P
-
K
E
C
G
D
L
C
P
G
T
M
E
E
K
P
M
C
E
K
T
T
I
N
N
E
Y
N
Y
R
C
W
T
T
N
R
C
Q
K
M
C
P
S
T
C
G
K
R
A
C
T
E
N
N
E
C
C
H
P
E
C
L
G
S
C
S
A
P
D
N
D
T
A
C
V
A
C
R
H
Y
Y
Y
A
G
V
C
V
P
A
C
P
P
N
T
Y
R
F
E
G
W
R
C
V
D
R
D
F
C
A
N
I
L
-
S
A
E
S
S
--
D
S
-
E
G
---
F
V
I
H
D
G
E
C
M
Q
E
C
P
S
G
F
I
R
N
G
S
Q
S
M
Y
C
I
P
C
E
G
P
C
P
K
V
C
E
E
E
K
K
-
T
K
T
I
D
S
V
T
S
A
Q
M
L
Q
G
C
T
I
F
K
G
N
L
L
I
N
I
R
R
G
N
N
I
A
S
E
L
E
N
F
M
G
L
I
E
V
V
T
G
Y
V
K
I
R
H
S
H
A
L
V
S
L
S
F
L
K
N
L
R
L
I
L
G
E
E
Q
L
E
G
N
Y
S
F
Y
V
L
D
N
Q
N
L
Q
Q
L
W
D
W
D
H
R
N
L
-
T
I
K
A
G
K
M
Y
F
A
F
N
P
K
L
C
V
S
E
I
Y
R
M
E
E
V
T
G
T
K
G
R
Q
S
K
G
D
I
N
T
R
N
N
G
E
R
A
S
C
E
S
D
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
50.97
99%
-114
- C2 -
-
5FXS
1
A:
[2-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
F
S
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
----
E
-----
N
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
A
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
E
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
42
Blastp_CBE
50.90
99%
-116
- C2 -
-
5HZN
4
IGF1R_HUMAN
D:
[1-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
A
-
M
----
A
-----
N
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
38
Blastp_CBE
50.85
99%
-118
- C2 -
-
5HZN
4
H:
[1-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
A
-
M
----
A
-----
N
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------
17
PsiBlast_PDB
50.82
99%
-110
- C2 -
-
1P4O
-
IGF1R_HUMAN
A:
[948-1255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Y
-
F
S
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
A
-
M
----
A
-----
N
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------
34
Blastp_CBE
50.59
100%
-113
- C2 -
-
3NW6
1
A:
[7-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
----
E
-----
N
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
35
Blastp_CBE
50.48
100%
-113
- C2 -
-
3NW5
1
A:
[6-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
----
E
-----
N
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
63
Blastp_CBE
49.70
99%
-126
- C2 -
-
3F5P
1
IGF1R_HUMAN
H:
[3-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
--------------
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
41
Blastp_CBE
49.70
99%
-119
- C2 -
-
5HZN
4
IGF1R_HUMAN
E:
[1-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------------
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
44
Blastp_CBE
49.63
99%
-121
- C2 -
-
5HZN
4
IGF1R_HUMAN
B:
[1-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------------
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
33
Blastp_CBE
49.42
100%
-112
- C2 -
-
3NW7
1
A:
[8-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
----
E
-----
N
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
28
Blastp_CBE
48.73
100%
-117
- C2 -
-
3LVP
1
IGF1R_HUMAN
B:
[36-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
---------------
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------
50
Blastp_CBE
48.72
100%
-113
- C2 -
-
4D2R
1
A:
[1-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
----
E
-----
N
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
75
Blastp_CBE
48.38
99%
-118
- C2 -
-
3D94
1
A:
[1-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---------------------------
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
36
Blastp_CBE
48.29
100%
-109
- C2 -
-
2OJ9
1
A:
[5-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
------------------
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
76
Blastp_CBE
48.23
99%
-119
- C2 -
-
1K3A
1
A:
[1-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
-----------------
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
54
Blastp_CBE
47.91
100%
-120
- C2 -
-
3QQU
1
IGF1R_HUMAN
A:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
--------------------------
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------
51
Blastp_CBE
47.62
100%
-112
- C2 -
-
3QQU
1
D:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
--------------
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------
31
Blastp_CBE
47.46
99%
-118
- C2 -
-
3I81
1
A:
[6-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
------
E
-----
N
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
------
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
53
Blastp_CBE
47.41
100%
-111
- C2 -
-
3QQU
1
IGF1R_HUMAN
B:
[3-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---------------------------
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
27
Blastp_CBE
47.24
100%
-120
- C2 -
-
3LVP
1
IGF1R_HUMAN
C:
[37-336]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
---------------
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
83
Blastp_CBE
47.17
81%
-106
- C2 -
-
4IBM
1
?
A:
[6-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
Y
V
P
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
----------------------------------------------------------------------------------
81
Blastp_CBE
47.17
80%
-103
- C2 -
-
5HHW
2
?
A:
[5-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
-----
Y
V
P
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
19
PsiBlast_PDB
47.15
100%
-121
- C2 -
-
5FXR
1
A:
[1-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
F
S
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
--
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
----
E
-----
N
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
------------------------------------------------------------------------------------
46
Blastp_CBE
46.95
99%
-114
- C2 -
-
3LW0
3
D:
[1-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------------------------
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
91
Blastp_CBE
46.94
79%
-110
- C2 -
-
1IR3
1
A:
[4-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
-----
F
V
P
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
26
Blastp_CBE
46.80
100%
-126
- C2 -
-
3LVP
2
D:
[36-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
-----------
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
---------------
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------
18
PsiBlast_PDB
46.75
100%
-113
- C2 -
-
5FXQ
1
A:
[2-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
F
S
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
--
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
-----------
N
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
49
Blastp_CBE
46.61
99%
-116
- C2 -
-
3LW0
3
IGF1R_HUMAN
A:
[1-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------------------------
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
90
Blastp_CBE
46.60
79%
-111
- C2 -
-
2Z8C
1
A:
[4-303]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
P
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
15
PsiBlast_PDB
46.52
100%
-126
- C2 -
-
3LVP
2
IGF1R_HUMAN
A:
[39-336]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
----
E
-------
P
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
--------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
99
Blastp_CBE
46.47
79%
-108
- C2 -
-
1RQQ
1
B:
[10-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
48
Blastp_CBE
46.45
99%
-114
- C2 -
-
3LW0
4
IGF1R_HUMAN
B:
[1-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------------------------
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
47
Blastp_CBE
46.37
99%
-112
- C2 -
-
3LW0
4
IGF1R_HUMAN
C:
[1-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------------------------
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
100
Blastp_CBE
46.33
79%
-108
- C2 -
-
1RQQ
1
INSR_HUMAN
A:
[10-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
85
Blastp_CBE
46.31
80%
-113
- C2 -
-
3EKN
1
A:
[8-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
----
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
29
Blastp_CBE
46.31
100%
-109
- C2 -
-
1JQH
1
C:
[6-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
---------------
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
--------
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
92
Blastp_CBE
46.22
79%
-109
- C2 -
-
1GAG
1
A:
[4-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
-----
F
V
P
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
80
Blastp_CBE
45.94
80%
-126
- C2 -
-
5E1S
1
A:
[8-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
Y
V
P
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
-------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
94
Blastp_CBE
45.93
79%
-115
- C2 -
-
3BU5
1
A:
[10-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
---
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
20
PsiBlast_PDB
45.66
100%
-107
- C2 -
-
1JQH
1
IGF1R_HUMAN
A:
[6-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
---------------
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
--------
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
52
Blastp_CBE
45.57
100%
-112
- C2 -
-
3QQU
1
IGF1R_HUMAN
C:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
M
-------------
V
L
A
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------
82
Blastp_CBE
45.54
81%
-107
- C2 -
-
4IBM
1
?
B:
[10-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
--------
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
30
Blastp_CBE
45.11
100%
-105
- C2 -
-
1JQH
1
IGF1R_HUMAN
B:
[6-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
-----
Y
V
P
D
E
--
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
-----
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------------------------
P
P
---------
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
--------
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
---
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------
89
Blastp_CBE
44.88
80%
-104
- C2 -
-
3ETA
1
INSR_HUMAN
A:
[12-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
-
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
88
Blastp_CBE
44.84
80%
-106
- C2 -
-
3ETA
1
B:
[12-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
86
Blastp_CBE
44.81
80%
-123
- C2 -
-
3EKK
1
A:
[5-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
-----
Y
V
P
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
--------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
----------------------------------------------------------------------------------
84
Blastp_CBE
43.86
80%
-114
- C2 -
-
1I44
1
A:
[9-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
167
Blastp_CBE
40.78
42%
-134
- C2 -
-
6D20
2
A:
[11-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
-
F
S
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
---------------
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
165
Blastp_CBE
40.32
42%
-141
- C2 -
-
6DKG
2
A:
[24-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-----------------
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
------
Y
S
T
D
Y
Y
-----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
180
Blastp_CBE
40.25
42%
-152
- C2 -
-
4AOJ
1
NTRK1_HUMAN
A:
[33-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
----
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
----------------
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
166
Blastp_CBE
40.05
42%
-148
- C2 -
-
6DKB
1
A:
[25-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
------------------------
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
-------
S
T
D
Y
Y
R
------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
207
Blastp_CBE
40.00
42%
-148
- C2 -
-
5JFV
1
A:
[16-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
---------------------
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
504
Blastp_CBE
39.91
40%
-138
- C2 -
-
4K9Y
1
A:
[8-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
-
Y
M
E
D
S
T
Y
Y
--
K
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
164
Blastp_CBE
39.84
42%
-137
- C2 -
-
6DKI
2
A:
[24-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-----------------
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
--
R
-
D
I
Y
S
T
D
Y
Y
-----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
168
Blastp_CBE
39.78
42%
-130
- C2 -
-
6D1Z
3
A:
[9-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
-
F
S
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-----------------
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
-----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
503
Blastp_CBE
39.77
40%
-160
- C2 -
-
4KAB
1
FAK1_HUMAN
A:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
---
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
548
Blastp_CBE
39.75
40%
-154
- C2 -
-
3PXK
1
FAK1_HUMAN
A:
[8-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
545
Blastp_CBE
39.69
40%
-150
- C2 -
-
4GU6
1
B:
[8-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
206
Blastp_CBE
39.67
42%
-144
- C2 -
-
5JFW
1
A:
[16-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
---------------------
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
208
Blastp_CBE
39.63
42%
-144
- C2 -
-
5JFS
1
A:
[16-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
---------------------
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
427
Blastp_CBE
39.52
42%
-132
- C2 -
-
6NPV
2
ABL1_HUMAN
A:
[18-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
------
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------
178
Blastp_CBE
39.51
42%
-148
- C2 -
-
4AOJ
1
C:
[33-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
--
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-----------------
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
------------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
474
Blastp_CBE
39.46
42%
-124
- C2 -
-
2QOH
1
ABL1_MOUSE
B:
[6-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
----
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
433
Blastp_CBE
39.41
42%
-131
- C2 -
-
3PYY
1
ABL1_HUMAN
A:
[18-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-----
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------
543
Blastp_CBE
39.36
40%
-151
* C2 *
-
4KAO
1
B:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
---
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
493
Blastp_CBE
39.36
42%
-123
- C2 -
-
1M52
3
ABL1_MOUSE
B:
[11-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------
549
Blastp_CBE
39.35
40%
-150
- C2 -
-
6I8Z
1
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
431
Blastp_CBE
39.33
42%
-132
- C2 -
-
6NPE
2
ABL1_HUMAN
A:
[18-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
------
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------
546
Blastp_CBE
39.31
40%
-136
- C2 -
-
4GU6
1
FAK1_HUMAN
A:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
---
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
-
Y
M
E
D
S
T
Y
Y
--
K
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
519
Blastp_CBE
39.25
40%
-158
- C2 -
-
2J0M
1
?
B:
[4-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
205
Blastp_CBE
39.27
42%
-144
- C2 -
-
5JFX
1
A:
[16-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
---------------------
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
555
Fugue
39.22
34%
-96
- C2 -
-
3CD3
3
A:
[1-376]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
------
D
F
L
V
R
E
S
Q
E
Y
V
L
S
V
P
R
H
F
I
I
N
L
Y
R
L
F
----
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
K
-----------------
D
K
--
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
------
D
N
--
T
L
V
A
V
K
S
C
R
-
P
----
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
-
N
I
V
R
L
I
G
V
C
----
T
Q
K
Q
-----
P
I
-
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
------
R
-
L
---------------------------
R
V
--
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
-
E
K
N
V
----
L
K
I
S
D
F
G
M
S
R
-
E
E
-
A
D
G
V
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
---
Y
Q
E
L
Q
S
I
R
K
R
H
----------------------------------------------------------------------------------------------
508
Blastp_CBE
39.22
40%
-154
- C2 -
-
4GU9
1
FAK1_HUMAN
A:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
---
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
472
Blastp_CBE
39.25
42%
-130
- C2 -
-
3KF4
1
ABL1_MOUSE
B:
[6-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
----
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
422
Blastp_CBE
39.22
42%
-126
- C2 -
-
2G1T
1
ABL1_HUMAN
D:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
419
Blastp_CBE
39.18
42%
-135
- C2 -
-
4YC8
3
ABL1_HUMAN
A:
[8-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
-----
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
420
Blastp_CBE
39.17
42%
-129
- C2 -
-
3UE4
1
ABL1_HUMAN
B:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
550
Blastp_CBE
39.16
40%
-149
- C2 -
-
2IJM
1
B:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
506
Blastp_CBE
39.12
40%
-148
- C2 -
-
4K8A
1
FAK1_HUMAN
A:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
---
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
502
Blastp_CBE
39.12
40%
-145
- C2 -
-
4KAB
1
B:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
-
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
-
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
429
Blastp_CBE
39.14
42%
-136
- C2 -
-
6NPU
2
ABL1_HUMAN
A:
[18-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
------
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------
179
Blastp_CBE
39.13
42%
-148
- C2 -
-
4AOJ
1
NTRK1_HUMAN
B:
[33-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
----
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-----------------
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
---------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
473
Blastp_CBE
39.12
42%
-122
- C2 -
-
3KF4
1
ABL1_MOUSE
A:
[6-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
------
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
552
Blastp_CBE
39.11
40%
-144
- C2 -
-
2ETM
1
B:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
494
Blastp_CBE
39.05
42%
-122
- C2 -
-
1M52
1
ABL1_MOUSE
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
513
Blastp_CBE
39.08
40%
-150
- C2 -
-
2JKM
1
A:
[4-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
471
Blastp_CBE
39.05
42%
-117
- C2 -
-
3KFA
1
ABL1_MOUSE
A:
[6-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
547
Blastp_CBE
39.02
40%
-147
- C2 -
-
3PXK
1
B:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
544
Blastp_CBE
39.00
40%
-154
- C2 -
-
4KAO
1
FAK1_HUMAN
A:
[8-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
----
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
479
Blastp_CBE
38.97
42%
-122
- C2 -
-
6HD6
2
ABL1_MOUSE
A:
[11-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
----
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
461
Blastp_CBE
38.96
42%
-125
- C2 -
-
2Z60
1
ABL1_MOUSE
A:
[6-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
---
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
480
Blastp_CBE
38.90
42%
-120
- C2 -
-
6HD4
2
ABL1_MOUSE
B:
[11-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
------
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
401
Blastp_CBE
38.92
43%
-132
- C2 -
-
4ZOG
2
ABL1_HUMAN
B:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
---
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
203
Blastp_CBE
38.90
42%
-146
- C2 -
-
6DKW
1
B:
[16-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
----------
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
440
Blastp_CBE
38.86
44%
-139
- C2 -
-
2HZI
1
ABL1_HUMAN
B:
[10-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
-------
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
38.86
42%
-128
- C2 -
-
2G1T
1
ABL1_HUMAN
B:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
507
Blastp_CBE
38.77
40%
-144
- C2 -
-
4GU9
1
B:
[8-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
---
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
-
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
459
Blastp_CBE
38.80
42%
-124
- C2 -
-
3IK3
1
ABL1_MOUSE
B:
[6-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
491
Blastp_CBE
38.76
42%
-122
- C2 -
-
1OPJ
2
ABL1_MOUSE
B:
[11-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
489
Blastp_CBE
38.76
42%
-121
- C2 -
-
3K5V
2
ABL1_MOUSE
A:
[11-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
-
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
551
Blastp_CBE
38.79
40%
-145
- C2 -
-
2IJM
1
FAK1_HUMAN
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
445
Blastp_CBE
38.75
42%
-120
- C2 -
-
2G2H
1
ABL1_HUMAN
A:
[8-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
--------------------------------------------------------------------------------------
396
Blastp_CBE
38.77
43%
-130
- C2 -
-
4TWP
1
ABL1_HUMAN
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
--
L
T
V
A
V
K
T
L
------
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
505
Blastp_CBE
38.73
40%
-138
- C2 -
-
4K8A
1
B:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
-
Y
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
444
Blastp_CBE
38.76
42%
-125
- C2 -
-
2G2H
1
ABL1_HUMAN
B:
[8-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
--------------------------------------------------------------------------------------
425
Blastp_CBE
38.75
42%
-128
- C2 -
-
2G1T
1
ABL1_HUMAN
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
447
Blastp_CBE
38.73
42%
-120
- C2 -
-
2G2F
1
ABL1_HUMAN
A:
[8-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
------------------------------------------------------------------------------------
403
Blastp_CBE
38.72
42%
-126
- C2 -
-
4WA9
1
ABL1_HUMAN
B:
[7-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
452
Blastp_CBE
38.69
42%
-120
- C2 -
-
2F4J
1
ABL1_HUMAN
A:
[7-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
423
Blastp_CBE
38.67
42%
-125
- C2 -
-
2G1T
1
ABL1_HUMAN
C:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
481
Blastp_CBE
38.66
42%
-122
- C2 -
-
6HD4
3
ABL1_MOUSE
A:
[11-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
-
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
501
Blastp_CBE
38.62
42%
-123
- C2 -
-
6BL8
1
ABL1_HUMAN
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
F
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
486
Blastp_CBE
38.62
42%
-124
- C2 -
-
3MS9
2
ABL1_MOUSE
B:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
------
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------
542
Blastp_CBE
38.61
40%
-144
- C2 -
-
3BZ3
1
A:
[1-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-------
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
-
Y
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
402
Blastp_CBE
38.60
43%
-124
- C2 -
-
4ZOG
5
ABL1_HUMAN
A:
[5-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
488
Blastp_CBE
38.57
42%
-118
- C2 -
-
3K5V
2
ABL1_MOUSE
B:
[11-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
------
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
175
Blastp_CBE
38.55
42%
-79
- C2 -
-
5KMJ
1
A:
[20-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
-----
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
---
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
G----
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
395
Blastp_CBE
38.54
43%
-131
- C2 -
-
4TWP
1
ABL1_HUMAN
B:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
518
Blastp_CBE
38.53
40%
-145
- C2 -
-
2JKQ
1
A:
[4-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
S
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
470
Blastp_CBE
38.48
42%
-116
- C2 -
-
3KFA
1
ABL1_MOUSE
B:
[6-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
477
Blastp_CBE
38.50
40%
-146
- C2 -
-
4EBV
3
A:
[28-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
T
R
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
P
-
E
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
405
Blastp_CBE
38.49
44%
-135
- C2 -
-
3QRK
1
ABL1_HUMAN
A:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
38.48
42%
-131
- C2 -
-
4YC8
3
ABL1_HUMAN
B:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
476
Blastp_CBE
38.46
40%
-150
- C2 -
-
4EBW
1
A:
[29-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
R
D
--
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
S
---
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
------
S
-
L
----
D
-----------------------
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
G
L
------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
KAQ
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
421
Blastp_CBE
38.42
42%
-120
- C2 -
-
3UE4
1
ABL1_HUMAN
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
492
Blastp_CBE
38.40
42%
-114
- C2 -
-
1OPJ
2
ABL1_MOUSE
A:
[11-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
482
Blastp_CBE
38.38
42%
-127
- C2 -
-
3MSS
2
ABL1_MOUSE
D:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
---------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
-
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------
454
Blastp_CBE
38.33
42%
-122
- C2 -
-
3OY3
1
ABL1_MOUSE
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
413
Blastp_CBE
38.32
44%
-132
- C2 -
-
2HYY
1
ABL1_HUMAN
D:
[6-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
38.27
42%
-119
- C2 -
-
3OY3
1
ABL1_MOUSE
B:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
428
Blastp_CBE
38.25
42%
-138
- C2 -
-
6NPU
5
ABL1_HUMAN
B:
[19-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
-------
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
475
Blastp_CBE
38.23
42%
-124
- C2 -
-
2QOH
1
ABL1_MOUSE
A:
[6-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
---
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
496
Blastp_CBE
38.19
42%
-123
- C2 -
-
1IEP
1
ABL1_MOUSE
A:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------
478
Blastp_CBE
38.16
42%
-117
- C2 -
-
6HD6
1
ABL1_MOUSE
B:
[11-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
------
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
457
Blastp_CBE
38.15
40%
-128
- C2 -
-
4XEY
1
ABL1_HUMAN
B:
[90-387]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
------------------
Y
---------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
------
K
Y
S
--
L
T
V
A
V
K
T
L
----
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
411
Blastp_CBE
38.14
44%
-138
- C2 -
-
2HZ4
1
ABL1_HUMAN
B:
[6-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
38.11
42%
-124
- C2 -
-
2G2I
1
ABL1_HUMAN
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
439
Blastp_CBE
38.10
44%
-132
- C2 -
-
3CS9
1
ABL1_HUMAN
A:
[10-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-------
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
38.08
44%
-129
- C2 -
-
2HZI
1
ABL1_HUMAN
A:
[10-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
38.02
42%
-126
- C2 -
-
3IK3
1
ABL1_MOUSE
A:
[6-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
--------
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------
430
Blastp_CBE
38.04
42%
-137
- C2 -
-
6NPE
3
ABL1_HUMAN
B:
[19-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
-------
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
458
Blastp_CBE
38.02
40%
-124
- C2 -
-
4XEY
1
ABL1_HUMAN
A:
[116-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
---------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
K
------
K
Y
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
500
Blastp_CBE
38.00
42%
-124
- C2 -
-
6BL8
1
ABL1_HUMAN
B:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
---
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
F
T
-
A
H
-
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
398
Blastp_CBE
37.98
44%
-139
- C2 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
--------
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
37.83
44%
-129
- C2 -
-
3CS9
1
ABL1_HUMAN
D:
[10-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------------
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
37.82
42%
-135
- C2 -
-
6NPV
5
ABL1_HUMAN
B:
[19-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
-------
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
484
Blastp_CBE
37.79
42%
-126
- C2 -
-
3MSS
2
ABL1_MOUSE
B:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
---------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
-
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------
483
Blastp_CBE
37.70
42%
-129
- C2 -
-
3MSS
2
ABL1_MOUSE
C:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
---------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
-
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------
495
Blastp_CBE
37.68
42%
-118
- C2 -
-
1IEP
1
ABL1_MOUSE
B:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------
435
Blastp_CBE
37.64
42%
-119
- C2 -
-
2HIW
1
ABL1_HUMAN
A:
[8-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------
485
Blastp_CBE
37.66
42%
-129
- C2 -
-
3MSS
2
ABL1_MOUSE
A:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
---------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
-
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------
487
Blastp_CBE
37.65
42%
-124
- C2 -
-
3MS9
2
ABL1_MOUSE
A:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
---------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
--
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------
434
Blastp_CBE
37.64
42%
-117
- C2 -
-
2HIW
1
ABL1_HUMAN
B:
[8-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------
416
Blastp_CBE
37.63
44%
-126
- C2 -
-
2HYY
1
ABL1_HUMAN
A:
[8-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
--
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
37.55
44%
-133
- C2 -
-
2HYY
1
ABL1_HUMAN
C:
[6-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
-
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
37.53
42%
-116
- C2 -
-
1FPU
1
ABL1_MOUSE
A:
[11-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------
410
Blastp_CBE
37.51
44%
-143
- C2 -
-
2HZ4
2
ABL1_HUMAN
C:
[7-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
K
K
Y
----------
T
V
A
V
K
T
L
K
--
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
37.47
42%
-120
- C2 -
-
2E2B
1
ABL1_HUMAN
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
-------
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
----
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
432
Blastp_CBE
37.47
42%
-135
- C2 -
-
3PYY
3
ABL1_HUMAN
B:
[19-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
-------
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
442
Blastp_CBE
37.49
42%
-123
- C2 -
-
2G2I
1
ABL1_HUMAN
B:
[8-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------
415
Blastp_CBE
37.47
44%
-128
- C2 -
-
2HYY
1
ABL1_HUMAN
B:
[6-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
-
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
37.39
42%
-128
- C2 -
-
3OXZ
1
ABL1_MOUSE
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
---------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
-------------
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
407
Blastp_CBE
37.39
44%
-132
- C2 -
-
3QRI
1
ABL1_HUMAN
A:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
37.38
42%
-120
- C2 -
-
2G2F
1
ABL1_HUMAN
B:
[9-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
437
Blastp_CBE
37.35
44%
-144
- C2 -
-
3CS9
1
ABL1_HUMAN
C:
[10-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
--------
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
37.33
44%
-124
- C2 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
37.32
42%
-118
- C2 -
-
2HZN
1
ABL1_MOUSE
A:
[11-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
-----
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------
409
Blastp_CBE
37.29
44%
-118
- C2 -
-
2HZ0
1
ABL1_HUMAN
A:
[6-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
37.27
44%
-135
- C2 -
-
3QRI
1
ABL1_HUMAN
B:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
------
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
37.18
42%
-115
- C2 -
-
1FPU
1
ABL1_MOUSE
B:
[11-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-------
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------
464
Blastp_CBE
37.07
39%
-117
- C2 -
-
2IVS
3
B:
[17-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
G
-
R
A
G
Y
--
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
N
H
P
-
H
V
I
K
L
Y
G
A
C
----
S
Q
D
G
-----
P
L
-
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
------------------------
R
A
L
---------
T
M
--
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
-
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
-
D
V
------------
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
---
S
K
D
L
E
K
M
M
-------------------------------------------------------------------------------------------------
438
Blastp_CBE
37.07
44%
-143
- C2 -
-
3CS9
1
ABL1_HUMAN
B:
[10-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
------
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
36.96
42%
-122
- C2 -
-
2E2B
1
ABL1_HUMAN
B:
[11-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
--------
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
--------
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
---------------------------------------------------------------------------------------------
190
Blastp_CBE
36.92
42%
-57
- C2 -
-
6PL2
1
A:
[15-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
171
Blastp_CBE
36.60
42%
-71
- C2 -
-
5KMN
1
A:
[2-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
-
F
S
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
---
D
K
--
M
L
V
A
V
K
A
L
K
-
E
--
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
-----G----
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
417
Blastp_CBE
36.57
44%
-124
- C2 -
-
5HU9
12
ABL1_HUMAN
A:
[10-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
----------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
36.56
44%
-141
- C2 -
-
2HZ0
1
ABL1_HUMAN
B:
[6-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
-----
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
36.41
42%
-71
- C2 -
-
5KML
1
A:
[2-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
-
F
S
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
---
D
K
--
M
L
V
A
V
K
A
L
K
-
E
--
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
-----G----
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
404
Blastp_CBE
36.15
42%
-127
- C2 -
-
4WA9
1
ABL1_HUMAN
A:
[10-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
------------------------
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
---------
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
G
D
T
Y
T
-
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
184
Blastp_CBE
35.93
43%
-60
- C2 -
-
4PMM
2
A:
[5-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
----
D
K
--
M
L
V
A
V
K
A
L
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
35.91
42%
-53
- C2 -
-
5KMM
1
A:
[12-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
-
F
S
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LGG--
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
197
Blastp_CBE
35.81
43%
-58
- C2 -
-
5KVT
2
A:
[4-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-----
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
35.78
42%
-57
- C2 -
-
6NSP
1
A:
[5-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
-----AGG--
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
174
Blastp_CBE
35.61
42%
-55
- C2 -
-
5KMK
1
A:
[14-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
-
F
S
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LGG--
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
163
Blastp_CBE
35.50
42%
-47
- C2 -
-
6NSS
1
A:
[9-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
------
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
177
Blastp_CBE
35.43
42%
-47
- C2 -
-
5H3Q
3
A:
[21-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
-
F
S
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
-------
K
--
M
L
V
A
V
K
A
L
K
-
E
-----
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
169
Blastp_CBE
35.35
42%
-78
- C2 -
-
6D1Y
1
A:
[17-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
-
F
S
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
----
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
L---------
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
-----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
87
Blastp_CBE
35.28
78%
27
- C2 -
-
4XLV
1
?
A:
[19-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
S
D
V
FPSSV
Y
V
P
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
162
Blastp_CBE
34.96
42%
-55
- C2 -
-
6PL3
1
A:
[16-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
--
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-------AGG--
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
125
Blastp_CBE
34.48
45%
-84
- C2 -
-
6E0R
1
A:
[15-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
----
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
189
Blastp_CBE
34.37
42%
-41
- C2 -
-
6NPT
1
A:
[1-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
-----
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
--------------GG---
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
149
Blastp_CBE
34.33
45%
-90
- C2 -
-
4FNY
1
A:
[20-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
-------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
-------------
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
176
Blastp_CBE
34.12
42%
-36
- C2 -
-
5KMI
1
A:
[20-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
------
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LG---
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
188
Blastp_CBE
34.07
42%
-60
- C2 -
-
5WR7
1
A:
[5-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
Y
-
F
S
D
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
159
Blastp_CBE
33.89
45%
-76
- C2 -
-
4TT7
5
A:
[5-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-------------
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
S
--
R
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
183
Blastp_CBE
33.81
43%
-69
- C2 -
-
4PMP
1
A:
[5-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
-----
K
--
M
L
V
A
V
K
A
L
K
------
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
--
I
Y
S
T
D
Y
Y
R
-
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
33.68
44%
-38
- C2 -
-
3LCT
3
A:
[27-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
P
N
-
D
P
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
G
Y
Y
R
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
118
Blastp_CBE
33.62
44%
-38
- C2 -
-
4MKC
3
A:
[50-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
G
Y
Y
R
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
389
Blastp_CBE
33.58
40%
-65
- C2 -
-
6KZC
1
?
A:
[5-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
S
P
-
T
K
D
K
--
M
L
V
A
V
K
A
L
K
-
D
P
-
T
L
A
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
G
D
G
D
-----
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------
D
A------------------
G
EL-------
G
L
--
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
A
N
L
L
----
V
K
I
G
D
F
G
M
S
R
--
V
Y
S
T
D
Y
Y
R
L---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
L
S
-
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
33.53
45%
-83
- C2 -
-
5IMX
1
A:
[25-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
----------
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
-----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
119
Blastp_CBE
33.36
44%
-37
- C2 -
-
3L9P
4
A:
[50-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
G
Y
Y
R
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
191
Blastp_CBE
33.35
42%
-55
- C2 -
-
6PL1
1
?
A:
[16-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
185
Blastp_CBE
33.30
44%
-60
- C2 -
-
4AT5
2
A:
[1-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
D
T
-----
F
V
Q
-----
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
------
K
--
I
L
V
A
V
K
T
L
K
-
D
A
S
D
-
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
V
E
G
D
-----
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------
D
-
A
VLMA
E
-----
G
N
P
---
P
T
---------
E
L
TQ
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
E
N
L
L
----
V
K
I
G
D
F
G
M
S
R
-
D
V
Y
S
T
D
Y
Y
R
-
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
33.30
42%
-58
- C2 -
-
5KMO
1
A:
[27-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
-----
H
-------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LGG--
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
--
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
512
Blastp_CBE
33.27
42%
-92
- C2 -
-
3DK7
1
ABL1_MOUSE
A:
[4-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-------
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
T
A
H
-
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
465
Blastp_CBE
33.20
39%
-41
- C2 -
-
2IVS
5
RET_HUMAN
A:
[17-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
G
-
R
A
G
Y
--
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
N
H
P
-
H
V
I
K
L
Y
G
A
C
----
S
Q
D
G
-----
P
L
-
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
VGPGYL------------------
R
A
L
---------
T
M
--
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
-
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
-
D
V
Y
E
E
D
S
Y
V
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
---
S
K
D
L
E
K
M
M
-------------------------------------------------------------------------------------------------
388
Blastp_CBE
33.17
40%
-62
- C2 -
-
6KZD
1
?
A:
[5-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
S
P
-
T
K
D
K
--
M
L
V
A
V
K
A
L
K
-
D
P
-
T
L
A
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
G
D
G
D
-----
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------
D
A------------------
G
EL-------
G
L
--
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
A
N
L
L
----
V
K
I
G
D
F
G
M
S
R
-
D
V
Y
S
T
D
Y
Y
R
L---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
L
S
-
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
33.12
44%
-104
- C2 -
-
4JOA
1
A:
[41-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
------
V
Y
E
G
Q
V
S
-----------
L
Q
V
A
V
K
T
L
P
----------
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
----------------
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
-----------
A
M
L
P
V
K
W
M
P
P
E
A
---
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
117
Blastp_CBE
33.02
44%
-41
- C2 -
-
3LCS
3
A:
[30-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
P
N
-
D
P
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
G
Y
Y
R
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
468
Blastp_CBE
33.00
44%
-98
- C2 -
-
2GQG
2
ABL1_HUMAN
A:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
T
A
H
-
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
32.98
42%
-92
- C2 -
-
2V7A
1
ABL1_HUMAN
B:
[8-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
T
A
H
-
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------
187
Blastp_CBE
32.96
44%
-64
- C2 -
-
4AT3
1
A:
[1-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
D
T
-----
F
V
Q
-----
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
-----
K
--
I
L
V
A
V
K
T
L
---
A
S
D
-
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
V
E
G
D
-----
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------
D
-
A
VLMA-------
N
P
---
P
T
---------
E
L
TQ
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
E
N
L
L
----
V
K
I
G
D
F
G
M
S
R
---
Y
S
T
D
Y
Y
R
-
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
32.89
43%
-60
- C2 -
-
4PMS
1
A:
[5-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
----
D
K
--
M
L
V
A
V
K
A
L
K
-----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
--
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
32.82
44%
-63
- C2 -
-
4AT4
1
A:
[1-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
D
T
-----
F
V
Q
-----
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
-----
K
--
I
L
V
A
V
K
T
L
K
-
D
A
S
D
-
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
V
E
G
D
-----
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
------
D
-
A
VLMA--------
P
---
P
T
---------
E
L
TQ
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
E
N
L
L
----
V
K
I
G
D
F
G
M
S
R
-
D
V
Y
S
T
D
Y
Y
R
-
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
32.69
42%
-86
- C2 -
-
2V7A
1
ABL1_HUMAN
A:
[7-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
T
A
H
-
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------
181
Blastp_CBE
32.58
43%
-70
- C2 -
-
4PMT
1
A:
[5-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-----
D
K
--
M
L
V
A
V
K
A
L
-----------
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
--
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
32.58
44%
-40
- C2 -
-
4Z55
3
A:
[22-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
--------------
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
G
Y
Y
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
510
Blastp_CBE
32.57
42%
-97
- C2 -
-
3DK6
1
ABL1_MOUSE
A:
[4-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
------
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
T
A
H
-
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------
194
Blastp_CBE
32.43
42%
-65
- C2 -
-
6J5L
1
A:
[11-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-----
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
-----
I
Y
S
T
D
Y
Y
R
-
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
357
Blastp_CBE
32.36
40%
-15
- C2 -
-
4J98
1
FGFR2_HUMAN
B:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
G
M
----
E
YSYDI
N
R
V
P
E
E
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
Q
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
204
Blastp_CBE
32.29
42%
-62
- C2 -
-
6DKW
1
NTRK1_HUMAN
A:
[16-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
E
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
---
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
467
Blastp_CBE
32.27
44%
-96
- C2 -
-
2GQG
2
ABL1_HUMAN
B:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
K
-
E
--
D
T
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
N
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
T
A
H
-
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
32.23
40%
-17
- C2 -
-
4J96
1
FGFR2_HUMAN
B:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
G
M
----
E
YSYDI
N
R
V
P
E
E
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
108
Blastp_CBE
32.19
44%
-39
- C2 -
-
4FOD
2
A:
[8-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
T
I
M
T
D
Y
N
P
N
Y
S
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
394
Blastp_CBE
32.18
40%
-25
- C2 -
-
5UGL
1
A:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
----------------------
R
V
P
E
E
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
V
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
196
Blastp_CBE
32.17
42%
-60
- C2 -
-
4YNE
2
A:
[11-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
---
D
K
--
M
L
V
A
V
K
A
L
K
-
E
------
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
------
S
T
D
Y
Y
-----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
113
Blastp_CBE
32.06
44%
-43
- C2 -
-
4FOC
1
A:
[36-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
152
Blastp_CBE
32.02
45%
-33
- C2 -
-
5FTO
1
A:
[1-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
-----
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
--------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
193
Blastp_CBE
32.00
43%
-62
- C2 -
-
5I8A
1
A:
[7-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
-------
K
--
M
L
V
A
V
K
A
L
K
----------
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
-
S
R
-
D
I
-
S
T
D
Y
Y
R
-
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
31.99
41%
-19
- C2 -
-
3JS2
1
FGFR1_HUMAN
A:
[23-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL--------------------
H
N
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
511
Blastp_CBE
31.98
42%
-90
- C2 -
-
3DK7
1
ABL1_MOUSE
B:
[4-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
-------
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
T
A
H
-
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------
195
Blastp_CBE
31.97
42%
-57
- C2 -
-
4YPS
1
A:
[11-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
L
L
----
D
K
--
M
L
V
A
V
K
A
L
-----
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
-----
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
------
D
-
A
----
K
LLAGG
E
D
V
A
P
G
P
L
---------
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
--
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
-
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
---
H
A
R
L
Q
----------------------------------------------------------------------------------------------------
126
Blastp_CBE
31.88
45%
-38
- C2 -
-
5KZ0
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
---------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
151
Blastp_CBE
31.86
45%
-44
- C2 -
-
5FTQ
2
A:
[1-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
337
Blastp_CBE
31.85
40%
-25
- C2 -
-
3RI1
1
?
A:
[18-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
-----------------
E
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
236
Blastp_CBE
31.77
41%
-15
- C2 -
-
4UWC
10
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL---
E
-
Y
----
S
-----
Y
-
P
S
H
N
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
134
Blastp_CBE
31.74
45%
-35
- C2 -
-
4CNH
2
B:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-------------
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
S
Y
------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
338
Blastp_CBE
31.69
39%
-7
- C2 -
-
4QRC
1
A:
[30-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
-
A
R
P
D
QA
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
----
T
Q
E
G
-----
P
L
-
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
-------------
G
P
D
L
S
P
D
GPRSSEGPL
S
F
--
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
G
V
H
H
I
D
Y
Y
K
-
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---
V
E
A
L
D
K
---------------------------------------------------------------------------------------------------
329
Blastp_CBE
31.69
40%
-24
- C2 -
-
2PWL
1
FGFR2_HUMAN
B:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
G----------------
E
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
301
Blastp_CBE
31.57
41%
-20
- C2 -
-
3C4F
1
FGFR1_HUMAN
A:
[8-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
541
Blastp_CBE
31.52
43%
-98
- C2 -
-
2P0C
2
MERTK_HUMAN
A:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
--
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
-----------
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
-------
I
-----
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
31.51
40%
-21
- C2 -
-
2PWL
1
FGFR2_HUMAN
A:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------------------------
E
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
327
Blastp_CBE
31.48
39%
-16
- C2 -
-
4UXQ
1
A:
[16-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
-
A
R
P
D
QA
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
----
T
Q
E
G
-----
P
L
-
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
--------------------GPL------
S
F
--
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
G
V
H
H
I
D
Y
Y
K
-
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---
V
E
A
L
D
K
---------------------------------------------------------------------------------------------------
300
Blastp_CBE
31.47
41%
-18
- C2 -
-
3C4F
1
B:
[8-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
154
Blastp_CBE
31.46
45%
-40
- C2 -
-
2XB7
1
A:
[3-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
----------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
132
Blastp_CBE
31.45
45%
-41
- C2 -
-
4CTC
1
A:
[10-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
---------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
370
Blastp_CBE
31.43
40%
-21
- C2 -
-
5UHN
1
FGFR2_HUMAN
A:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
------------------------
E
E
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
148
Blastp_CBE
31.41
45%
-36
- C2 -
-
5AA9
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
142
Blastp_CBE
31.41
45%
-41
- C2 -
-
2XP2
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-------------
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
136
Blastp_CBE
31.41
45%
-37
- C2 -
-
4CMU
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
147
Blastp_CBE
31.35
45%
-37
- C2 -
-
5AAA
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
158
Blastp_CBE
31.34
44%
-41
- C2 -
-
4ANQ
1
A:
[24-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
A
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
140
Blastp_CBE
31.34
45%
-37
- C2 -
-
4CCU
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
141
Blastp_CBE
31.31
45%
-37
- C2 -
-
4CCB
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-------------
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
374
Blastp_CBE
31.29
40%
-7
- C2 -
-
4J99
1
B:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
G
M
----
E
YSYD-------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
509
Blastp_CBE
31.26
42%
-96
- C2 -
-
3DK6
1
ABL1_MOUSE
B:
[5-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
M
E
R
T
D
I
T
M
K
H
K
-------
E
V
Y
E
G
V
W
K
K
Y
------
S
--
L
T
V
A
V
K
T
L
------
E
V
E
--
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
-
N
L
V
Q
L
L
G
V
C
----
T
R
E
P
-----
P
F
-
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
----
V
-----
S
A
V
V
L
-------------------
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
-
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
T
A
H
-
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
-------
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
------------------------------------------------------------------------------------
156
Blastp_CBE
31.29
45%
-36
- C2 -
-
5AAB
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
--
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
111
Blastp_CBE
31.26
44%
-35
- C2 -
-
3AOX
5
A:
[19-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
I
M
T
D
Y
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
121
Blastp_CBE
31.25
45%
-39
- C2 -
-
4CLJ
1
A:
[10-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
139
Blastp_CBE
31.22
45%
-39
- C2 -
-
4CLI
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
131
Blastp_CBE
31.18
45%
-34
- C2 -
-
4FNZ
1
A:
[10-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
G
------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
-----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
218
Blastp_CBE
31.13
41%
-18
- C2 -
-
6ITJ
1
?
A:
[14-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
133
Blastp_CBE
31.13
45%
-39
- C2 -
-
4CTB
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
---
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
336
Blastp_CBE
31.11
40%
-22
- C2 -
-
3RI1
1
FGFR2_HUMAN
B:
[18-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
----
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
-----------------
E
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
110
Blastp_CBE
31.12
44%
-33
- C2 -
-
4DCE
1
ALK_HUMAN
A:
[16-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
------
P
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
----------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
157
Blastp_CBE
31.11
45%
-34
- C2 -
-
5AA8
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
378
Blastp_CBE
31.09
40%
-18
- C2 -
-
4J95
1
?
B:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------------------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
143
Blastp_CBE
31.06
45%
-36
- C2 -
-
5AAC
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
120
Blastp_CBE
31.04
45%
-37
- C2 -
-
4CD0
1
A:
[25-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
114
Blastp_CBE
30.99
44%
-35
- C2 -
-
4FOB
1
A:
[36-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-------------
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
138
Blastp_CBE
30.95
45%
-35
- C2 -
-
4CMO
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
127
Blastp_CBE
30.89
45%
-32
- C2 -
-
5IUI
1
A:
[10-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
-----
P
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
123
Blastp_CBE
30.87
45%
-38
- C2 -
-
6EDL
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
144
Blastp_CBE
30.86
45%
-34
- C2 -
-
5A9U
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
359
Blastp_CBE
30.82
39%
-12
- C2 -
-
6IUP
2
?
A:
[29-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
-
A
R
P
D
QA
S
T
V
A
V
K
M
L
K
---
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
----
T
Q
E
G
-----
P
L
-
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
---------------------------PRSSEGPL-
S
F
--
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
G
V
H
H
I
D
Y
Y
K
-
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---
V
E
A
L
D
K
---------------------------------------------------------------------------------------------------
220
Blastp_CBE
30.79
41%
-21
- C2 -
-
5Z0S
1
FGFR1_HUMAN
A:
[14-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
146
Blastp_CBE
30.79
45%
-42
- C2 -
-
6MX8
1
A:
[1-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
-----------
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
---------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
122
Blastp_CBE
30.78
45%
-37
- C2 -
-
2YFX
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
145
Blastp_CBE
30.77
44%
-37
- C2 -
-
4ANS
1
A:
[24-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
A
D
F
G
M
A
R
-
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
366
Blastp_CBE
30.75
40%
-18
- C2 -
-
3B2T
1
FGFR2_HUMAN
A:
[16-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
----
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
------------------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
373
Blastp_CBE
30.69
40%
-4
- C2 -
-
4J99
1
?
C:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
G
M
----
E
YSYD-------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
109
Blastp_CBE
30.61
44%
-41
- C2 -
-
4DCE
1
B:
[17-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
S
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
----
E
V
Y
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
-----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
377
Blastp_CBE
30.48
40%
-15
- C2 -
-
4J95
1
?
C:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
--------------------------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
540
Blastp_CBE
30.47
43%
-94
- C2 -
-
2P0C
1
B:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
-----------
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
-------
I
-----
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
554
Fugue
30.46
76%
-2
- C2 -
-
1IR3
1
A:
[4-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
F
V
P
--------
D
E
--
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
-----
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
------
E
-
A
----
E
-----
N
N
P
G
R
P
P
P
---------
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
-R
D
I
E
T
D
R
K
G
G
-
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N-
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
---
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------
248
Blastp_CBE
30.42
41%
-25
- C2 -
-
4F64
3
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
137
Blastp_CBE
30.42
45%
-36
- C2 -
-
4CMT
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-------------
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
318
Blastp_CBE
30.41
42%
-36
- C2 -
-
4YMJ
4
NTRK3_HUMAN
A:
[11-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
S
P
-
T
K
D
K
--
M
L
V
A
V
K
A
L
K
-
D
P
-
T
L
A
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
G
D
G
D
-----
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
--------------------------
G
EL-------
G
L
--
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
A
N
L
L
----
V
K
I
G
D
F
G
----
D
V
Y
S
T
D
Y
Y
R
----
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
L
S
-
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
30.39
41%
-22
- C2 -
-
4F63
3
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
372
Blastp_CBE
30.38
40%
-28
- C2 -
-
4J99
1
?
D:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
--------------------------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
317
Blastp_CBE
30.35
42%
-38
- C2 -
-
4YMJ
4
B:
[11-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
S
P
-
T
K
D
K
--
M
L
V
A
V
K
A
L
K
-
D
P
-
T
L
A
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
G
D
G
------
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
--------------------------
G
EL-------
G
L
--
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
A
N
L
L
----
V
K
I
G
D
F
G
M
S
R
-
D
V
Y
S
T
D
Y
Y
R
----
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
L
S
-
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
30.32
43%
-75
- C2 -
-
3BRB
2
MERTK_HUMAN
A:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
---
N
S
S
Q
R
E
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IE------------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
30.30
45%
-39
- C2 -
-
4CNH
1
ALK_HUMAN
A:
[10-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
------
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
365
Blastp_CBE
30.17
40%
-17
- C2 -
-
3B2T
1
B:
[16-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
---
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
------------------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
153
Blastp_CBE
30.14
45%
-46
- C2 -
-
2XBA
1
A:
[3-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
-------
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
----
S
-----
Q
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
-----------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
285
Blastp_CBE
30.10
41%
-2
- C2 -
-
5VND
9
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PG------------------------
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
128
Blastp_CBE
30.09
45%
-40
- C2 -
-
5IUH
1
A:
[10-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
-----
G
E
V
Y
E
G
Q
V
S
G
-------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-------------
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
---------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
129
Blastp_CBE
30.04
45%
-39
- C2 -
-
5IUG
1
A:
[10-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
--------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
-------------
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
--------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
304
Blastp_CBE
30.02
42%
-45
- C2 -
-
3V5Q
1
B:
[11-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
R
E
L
G
---
F
-
K
V
F
L
A
E
C
Y
N
L
S
P
-
T
K
D
K
--
M
L
V
A
V
K
A
L
K
-
D
P
-
T
L
A
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
------
G
D
-----
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---------------------------EL-------
G
L
--
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
A
N
L
L
----
V
K
I
G
D
F
G
M
---
D
V
Y
S
T
D
Y
Y
R
-----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
L
S
-
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
29.95
40%
-24
- C2 -
-
4J99
1
FGFR2_HUMAN
A:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------------------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
--
D
Y
Y
K
---
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
160
Blastp_CBE
29.95
49%
-37
- C2 -
-
4UXL
1
A:
[32-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
L
T
L
R
L
L
L
G
S
G
A
F
G
E
V
Y
E
G
T
A
V
D
I
L
G
V
G
S
G
E
--
I
K
V
A
V
K
T
L
K
-
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
N
H
P
-
N
I
L
K
Q
L
G
V
C
----
L
L
N
E
-----
P
Q
-
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
------
A
-
T
----
F
-----
Y
G
P
L
L
T
------------
L
--
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
V
K
D
Y
T
SPRI
V
K
I
G
D
F
G
L
A
R
-
D
I
Y
K
---------
E
G
L
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
-
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
---
Q
D
Q
L
Q
----------------------------------------------------------------------------------------------------
124
Blastp_CBE
29.95
45%
-33
- C2 -
-
6EBW
1
A:
[12-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
---
T
S
-----
S
I
S
D
L
--
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
--
F
G
E
V
Y
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
-----
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
------
R
-
P
-----------
P
S
S
L
A
------------
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
-
D
---------------
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
---
L
E
R
I
E
----------------------------------------------------------------------------------------------------
520
Blastp_CBE
29.93
43%
-88
- C2 -
-
6MEP
1
B:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
------------------
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
---------------P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
--
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
29.92
40%
-34
- C2 -
-
5UGL
1
?
B:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
--------------------------
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
V
I
------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
315
Blastp_CBE
29.87
43%
-38
- C2 -
-
5U6B
1
UFO_HUMAN
B:
[20-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
L
N
Q
---
S
I
--
L
K
V
A
V
K
T
M
K
-
I
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
-
N
V
M
R
L
I
G
V
C
----
F
---RESFP
A
P
-
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
L
Y
S
------
R
-
L
----
G
-----
D
Q
P
V
Y
L
P
T
---------
Q
M
----
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
---
N
-
E
N
M
S
----
V
C
V
A
D
F
G
L
S
K
-
K
I
Y
N
G
D
Y
Y
----
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
-
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
29.81
41%
-4
- C2 -
-
5AM6
1
FGFR1_HUMAN
A:
[16-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PG------------------------
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
369
Blastp_CBE
29.82
40%
-30
- C2 -
-
5UHN
2
B:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
--------------------------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
210
Blastp_CBE
29.81
42%
1
- C2 -
-
5AM7
1
FGFR1_HUMAN
A:
[16-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PG-----------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
235
Blastp_CBE
29.73
41%
-10
- C2 -
-
4UWC
9
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL---
E
-
Y
----
S
-----
Y
---
H
N
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
539
Blastp_CBE
29.71
43%
-67
- C2 -
-
3BPR
1
MERTK_HUMAN
A:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
------
R
E
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IEMS
S
----------P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
29.69
43%
-39
- C2 -
-
5U6B
1
D:
[20-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
L
N
Q
---
S
I
--
L
K
V
A
V
K
T
M
K
-
I
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
-
N
V
M
R
L
I
G
V
C
----
F
---RESFP
A
P
-
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
L
Y
S
------
R
-
L
----
G
-----
D
Q
P
V
Y
L
P
T
---------
Q
M
----
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
---
N
-
E
N
M
S
----
V
C
V
A
D
F
G
L
S
K
-
K
I
Y
N
G
D
Y
Y
----
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
-
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
29.63
49%
-32
- C2 -
-
3ZBF
1
A:
[32-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
L
T
L
R
L
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
I
L
G
V
G
S
G
E
--
I
K
V
A
V
K
T
L
K
-
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
N
H
P
-
N
I
L
K
Q
L
G
V
C
----
L
L
N
E
-----
P
Q
-
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
------
A
-
T
----
F
-----
Y
G
P
L
L
T
------------
L
--
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
V
K
D
Y
T
SPRI
V
K
I
G
D
F
G
L
A
R
-
D
I
Y
-------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
-
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
---
Q
D
Q
L
Q
----------------------------------------------------------------------------------------------------
262
Blastp_CBE
29.53
41%
-41
- C2 -
-
6MZQ
1
B:
[17-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-----------------------------L--------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
---------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
211
Blastp_CBE
29.53
42%
-27
- C2 -
-
4RWK
1
B:
[23-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
------
I
D
Y
Y
K
-
K
T
--
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
305
Blastp_CBE
29.52
42%
-44
- C2 -
-
3V5Q
1
NTRK3_HUMAN
A:
[11-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
R
E
L
------
K
V
F
L
A
E
C
Y
N
L
S
P
-
T
K
D
K
--
M
L
V
A
V
K
A
L
---
P
-
T
L
A
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
G
D
G
D
-----
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---------------------------EL-------
G
L
--
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
A
N
L
L
----
V
K
I
G
D
F
G
M
---
D
V
Y
S
T
D
Y
Y
R
-----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
L
S
-
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
29.46
41%
-33
- C2 -
-
1FGI
1
B:
[16-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
-
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
219
Blastp_CBE
29.46
41%
-19
- C2 -
-
5Z0S
1
B:
[14-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
-
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
319
Blastp_CBE
29.45
40%
-35
- C2 -
-
6NVK
1
A:
[12-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
D
P
-
A
R
P
D
QA
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
----
T
Q
E
G
-----
P
L
-
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
-
G
----
S
-----
S
E
---
G
P
L
---------
S
F
--
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---
V
E
A
L
D
K
---------------------------------------------------------------------------------------------------
270
Blastp_CBE
29.39
41%
-32
- C2 -
-
6C19
1
B:
[17-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------------EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
286
Blastp_CBE
29.28
41%
-7
- C2 -
-
5VND
10
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL---
E
-
Y
----
S
-----
Y
N
P
S
H
N
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
-
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
379
Blastp_CBE
29.27
40%
-18
- C2 -
-
4J95
1
FGFR2_HUMAN
A:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------------------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
----
Y
Y
K
-
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
297
Blastp_CBE
29.20
41%
-27
- C2 -
-
6NVL
1
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P--------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
---------
Y
Y
K
-
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
215
Blastp_CBE
29.18
41%
-28
- C2 -
-
3RHX
2
B:
[12-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
537
Blastp_CBE
29.14
43%
-68
- C2 -
-
3BPR
1
MERTK_HUMAN
C:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
--------
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IEMS----------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
29.11
41%
-20
- C2 -
-
5UR1
1
FGFR1_HUMAN
A:
[17-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P------------------
Y
N
P
S
H
N
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
266
Blastp_CBE
28.92
41%
-31
- C2 -
-
6C1C
1
B:
[17-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
382
Blastp_CBE
28.89
40%
-21
- C2 -
-
2PVY
1
?
B:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
G------DI---
N
R
V
P
E
E
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
--
Y
Y
K
-----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
360
Blastp_CBE
28.89
39%
-33
- C2 -
-
6IUO
1
?
A:
[29-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
---
A
R
P
D
QA
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
----
T
Q
E
G
-----
P
L
-
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
--------------------GPL------
S
F
--
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---
V
E
A
L
D
K
---------------------------------------------------------------------------------------------------
376
Blastp_CBE
28.83
40%
-26
- C2 -
-
4J95
2
?
D:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
--------------------------
Q
M
---------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
238
Blastp_CBE
28.80
41%
-10
- C2 -
-
4UWB
4
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL---
E
-
Y
----
S
-------
P
S
H
N
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
-
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
306
Blastp_CBE
28.78
41%
-27
- C2 -
-
3GQL
1
C:
[23-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P--------------------------EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
526
Blastp_CBE
28.73
43%
-63
- C2 -
-
4MHA
1
B:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
---------------------
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IEMS
S
Q
G
I
-----
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
28.72
43%
-62
- C2 -
-
4MH7
1
MERTK_HUMAN
A:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
------------------
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IEMS
S
Q
G
I
-----
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
28.71
41%
-31
- C2 -
-
4F64
3
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
-
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
249
Blastp_CBE
28.64
41%
-30
- C2 -
-
4F63
3
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
-
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
245
Blastp_CBE
28.57
41%
-26
- C2 -
-
4F65
4
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
--------
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
307
Blastp_CBE
28.55
41%
-25
- C2 -
-
3GQL
1
FGFR1_HUMAN
B:
[23-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P------------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
239
Blastp_CBE
28.55
41%
-29
- C2 -
-
4NKS
1
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
-
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
241
Blastp_CBE
28.40
41%
-19
- C2 -
-
4NKA
2
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P--------------------------EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
-------
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
522
Blastp_CBE
28.33
43%
-57
- C2 -
-
5K0X
1
B:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
--
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
------------
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IEMS
S
Q
G
I
-----
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
28.31
43%
-62
- C2 -
-
5K0K
1
B:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
--
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
-----------------
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IEMS
S
Q
G
I
-----
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
28.22
43%
-58
- C2 -
-
3TCP
1
B:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
---------------
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IEMS
S
Q
G
I
-----
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
---------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
28.11
41%
-19
- C2 -
-
4V01
6
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
L
A
E
A
I
G
L
D
----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
---------
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
309
Blastp_CBE
28.08
40%
20
- C2 -
-
5A46
2
B:
[22-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
-----
E
L
P
E
D
PR
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P----------------------
H
N
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
308
Blastp_CBE
28.07
41%
-19
- C2 -
-
3GQL
1
FGFR1_HUMAN
A:
[23-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P--------------------------EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
--------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
342
Blastp_CBE
27.99
39%
-19
- C2 -
-
4TYJ
2
A:
[18-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
D
P
-
A
R
P
D
QA
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
----
T
Q
E
G
-----
P
L
-
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
---------------------------PL-------
S
F
--
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
-----------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---
V
E
A
L
D
K
---------------------------------------------------------------------------------------------------
272
Blastp_CBE
27.96
41%
-28
- C2 -
-
6C18
1
B:
[17-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
----------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
264
Blastp_CBE
27.89
41%
-29
- C2 -
-
6C1O
1
B:
[17-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
----
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
209
Blastp_CBE
27.75
42%
5
- C2 -
-
5AM7
1
B:
[16-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PG-----------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
------
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
237
Blastp_CBE
27.73
41%
-6
- C2 -
-
4UWB
3
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL---
E
-
Y
----
S
-----
Y
---
H
N
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
----
H
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
274
Blastp_CBE
27.69
41%
-24
- C2 -
-
5UR1
1
B:
[17-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
240
Blastp_CBE
27.56
41%
-22
- C2 -
-
4NKS
1
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
--------
N
RV
T
K
V
A
V
K
M
L
K
--
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P--------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
-------
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
234
Blastp_CBE
27.49
41%
-16
- C2 -
-
4V01
7
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P--------------------------QL-------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
---------
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
299
Blastp_CBE
27.48
41%
-13
- C2 -
-
6MZW
1
FGFR1_HUMAN
A:
[17-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL---
E
-
Y
----
S
-----
Y
N
P
S
--
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
246
Blastp_CBE
27.43
41%
-6
- C2 -
-
4F65
6
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P------------------------
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
-----------
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
531
Blastp_CBE
27.34
43%
-62
- C2 -
-
4M3Q
1
MERTK_HUMAN
A:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
--------------------
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IEMS
S
Q
G
I
-----
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
--
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
27.21
43%
-68
- C2 -
-
5TD2
1
MERTK_HUMAN
A:
[6-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
-----------------
A
A
C
M
K
D
F
S
H
P
-
N
V
M
R
L
L
G
V
C
IEMS
S
----------P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
----
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
27.18
43%
-43
- C2 -
-
6MEP
1
MERTK_HUMAN
A:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
------------
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
I--------------P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
27.17
39%
-13
- C2 -
-
4TYI
1
A:
[18-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
-
A
R
P
D
QA
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
----
T
Q
E
G
-----
P
L
-
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
--------------------PL-------
S
F
--
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
G
---------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---
V
E
A
L
D
K
---------------------------------------------------------------------------------------------------
232
Blastp_CBE
27.10
41%
1
- C2 -
-
4V04
7
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL---
E
-
Y
----
S
-------
P
S
H
N
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
---------
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
325
Blastp_CBE
26.97
40%
-15
- C2 -
-
5XFJ
1
A:
[18-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
-
A
R
P
D
QA
S
T
V
A
V
K
M
L
K
-
D
---
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
----
T
Q
E
G
-----
P
L
-
Y
V
I
M
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
-------------
G
P
-----PL-------
S
F
--
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---
V
E
A
L
D
K
---------------------------------------------------------------------------------------------------
273
Blastp_CBE
26.80
41%
-1
- C2 -
-
6C18
1
FGFR1_HUMAN
A:
[17-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PG-----------
S
-----
Y
N
P
S
H
N
P
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
331
Blastp_CBE
26.79
39%
-14
- C2 -
-
5JKG
1
A:
[18-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
-
A
R
P
D
QA
S
T
V
A
V
K
M
L
K
-
D
---
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
----
T
Q
E
G
-----
P
L
-
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
-------------
G
P
-----PL-------
S
F
--
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---
V
E
A
L
D
K
---------------------------------------------------------------------------------------------------
525
Blastp_CBE
26.74
43%
-29
- C2 -
-
5K0K
1
MERTK_HUMAN
A:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IE-----------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
26.72
40%
-30
- C2 -
-
2PVF
1
A:
[29-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
---
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------
P
G
M
----
E
-----
S
Y
D
-----M--------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
--
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
534
Blastp_CBE
26.66
43%
-22
- C2 -
-
3BRB
2
B:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IEMS
S
Q
G
I
-----
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
26.34
43%
-34
- C2 -
-
3TCP
1
MERTK_HUMAN
A:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
-----
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IE-----------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
26.01
40%
-10
- C2 -
-
6AGX
1
?
C:
[7-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
-
D
K
P
K
EA
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
----------------------
N
R
V
P
E
EQM------
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
I
N
-----
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
530
Blastp_CBE
25.83
43%
-46
- C2 -
-
4M3Q
1
B:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
-----
G
S
V
M
E
G
N
L
K
--------
S
--
L
K
V
A
V
K
T
M
-------------
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
I-------------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
25.81
43%
-27
- C2 -
-
4MHA
1
MERTK_HUMAN
A:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IE-----------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
25.52
40%
33
- C2 -
-
5A46
4
FGFR1_HUMAN
A:
[28-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
PR
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
-----
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL-----------------------
E
EQL------
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-
D
---
I
D
Y
Y
K
-
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---
V
E
D
L
-----------------------------------------------------------------------------------------------------
314
Blastp_CBE
25.41
43%
-4
- C2 -
-
5U6B
1
UFO_HUMAN
C:
[20-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
L
N
Q
-
D
D
S
I
--
L
K
V
A
V
K
T
M
K
-
I
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
-
N
V
M
R
L
I
G
V
C
----
F
Q
--P----
A
P
-
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
L
Y
S
------
R
-
L
----
G
-----
D
Q
P
V
Y
L
P
T
---------
Q
M
----
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
---
N
-
E
N
M
S
----
V
C
V
A
D
F
G
L
S
K
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
-
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
25.39
43%
-4
- C2 -
-
5U6B
1
UFO_HUMAN
A:
[20-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
L
N
Q
-
D
D
S
I
--
L
K
V
A
V
K
T
M
K
-
I
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
H
P
-
N
V
M
R
L
I
G
V
C
----
F
Q
--P----
A
P
-
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
L
Y
S
------
R
-
L
----
G
-----
D
Q
P
V
Y
L
P
T
---------
Q
M
----
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
---
N
-
E
N
M
S
----
V
C
V
A
D
F
G
L
S
K
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
V
E
-
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
25.13
43%
-26
- C2 -
-
5K0X
1
MERTK_HUMAN
A:
[31-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
--
I
E
E
-
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
IE-----------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
------
R
-
L
----
E
-----
T
G
P
K
H
I
P
-----------
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
-
N
H
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M
Y
D
Y
L
L
H
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H
R
L
K
Q
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E
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C
L
D
E
L
Y
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I
M
Y
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C
W
R
T
D
P
L
D
R
P
T
F
---------------------------------------------------------------------------------------------------------------