@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KAPCA_HUMAN: (2021-11-22 )
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Atome Classification :
(273 SA)
------------------------------------.........10........20........30.......-.40----........50..-......60.---.---.---..-...----70........80..-......90.....-.--..---100-.........110...-....120.......130....-.-..140.......150.......160........170....-...180.......-----------------------------190-.--.-----..----.----..---------.-.200--.........210..---.-----....220.......230....-...----240..--..-----...250..------.--..--..-----260-........270.......280...-..-.-...290.......300---.......310.......320.......-330......---.---.340----.------........350
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------MGN
A
A
AAKKGS
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
WESPAQN
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
LGTG-SF
G
R
V
M
L
V
K
---H---K---ET-GN
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--AV---N---
F
P
F
L
V
K
L
E
F
S
FKDNS-
N
L
Y
M
V
M
E
YVP
G
G
E
M
F
S
H
L
R
R
I-G-RFSEPHA
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
DLKPE
N
L
L
ID-QQG
Y
I
Q
VTDF
G
F
A
-----------------------------
K
---R--V-----KG----
R
----
T
W
---------
T
-
L
C----GTPEYL
A
P
E
I
I
LSK---G-----YNK
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
AAGY-PPF----FAD
Q
P
--
I
Q
-----
I
Y
E
K
I
VSG------K--VR--F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
IKNH
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
KVEAPFIPKFKGPGDTSNFD-D-YE
E
E
E
I
R
---
V
---S
I
------
N
------
E
K
C
G
K
E
F
SEF
17
PsiBlast_PDB
96.44
99%
0
- C- -
-
4UJ9
-
A:
[11--1]
----------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
-----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
163
Blastp_CBE
94.90
97%
-90
- C1 -
-
5M6V
1
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
283
Blastp_CBE
94.67
97%
-85
- C1 -
-
5N1L
4
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
--
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
250
Blastp_CBE
94.67
97%
-91
- C1 -
-
5OTG
1
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
160
Blastp_CBE
94.59
97%
-91
- C1 -
-
5M75
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
92
Blastp_CBE
94.51
98%
-91
- C1 -
-
1SMH
6
KAPCA_BOVIN
A:
[1-350]
-------------------------------------
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
E
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
154
Blastp_CBE
94.39
97%
-86
- C1 -
-
5N7P
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
168
Blastp_CBE
94.36
97%
-95
- C1 -
-
5LCU
5
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
169
Blastp_CBE
94.31
97%
-89
- C1 -
-
5LCT
4
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
244
Blastp_CBE
94.25
97%
-92
- C1 -
-
6EH3
1
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
167
Blastp_CBE
94.15
97%
-86
- C1 -
-
5M0B
4
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
172
Blastp_CBE
94.05
97%
-90
- C1 -
-
5LCP
5
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
282
Blastp_CBE
94.01
97%
-88
- C1 -
-
5N1M
3
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
--
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
278
Blastp_CBE
93.98
97%
-87
- C1 -
-
5N36
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
--
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
248
Blastp_CBE
93.97
97%
-90
- C1 -
-
5OUC
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
161
Blastp_CBE
93.97
97%
-92
- C1 -
-
5M71
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
171
Blastp_CBE
93.96
97%
-88
- C1 -
-
5LCQ
3
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
153
Blastp_CBE
93.89
97%
-81
- C1 -
-
5N7U
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
25
Blastp_CBE
93.86
99%
-93
- C1 -
-
5J5X
1
KAPCA_HUMAN
A:
[10-351]
---------------------------------------------
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
275
Blastp_CBE
93.71
97%
-84
- C1 -
-
5N3A
4
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
271
Blastp_CBE
93.70
97%
-86
- C1 -
-
5N3E
3
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
279
Blastp_CBE
93.66
97%
-87
- C1 -
-
5N33
3
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
--
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
229
Blastp_CBE
93.66
97%
-89
- C1 -
-
6I2H
1
?
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
281
Blastp_CBE
93.63
97%
-83
- C1 -
-
5N1N
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
274
Blastp_CBE
93.59
97%
-86
- C1 -
-
5N3B
2
KAPCA_CRIGR
A:
[7-353]
---------------------------------------
A
A
A
A
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
255
Blastp_CBE
93.58
97%
-90
- C1 -
-
5O0E
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
272
Blastp_CBE
93.49
97%
-86
- C1 -
-
5N3D
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
--
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
253
Blastp_CBE
93.47
97%
-88
- C1 -
-
5OK3
1
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
277
Blastp_CBE
93.36
97%
-82
- C1 -
-
5N37
6
KAPCA_CRIGR
A:
[1-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
276
Blastp_CBE
93.26
97%
-87
- C1 -
-
5N39
5
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
--
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
240
Blastp_CBE
93.14
97%
-87
- C1 -
-
6EMB
1
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
49
Blastp_CBE
93.12
99%
-85
- C1 -
-
3VQH
2
KAPCA_HUMAN
A:
[5-351]
---------------------------------------
A
A
A
A
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
233
Blastp_CBE
93.05
97%
-86
- C1 -
-
6I2A
1
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
45
Blastp_CBE
93.00
99%
-85
- C1 -
-
5BX7
4
KAPCA_HUMAN
A:
[6-351]
----------------------------------------
A
A
A
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
273
Blastp_CBE
92.85
97%
-83
- C1 -
-
5N3C
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
-
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
256
Blastp_CBE
92.59
97%
-94
- C1 -
-
5NTJ
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
---
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
228
Blastp_CBE
92.59
97%
-84
- C1 -
-
4DFX
5
KAPCA_MOUSE
E:
[1-350]
-------------------------------------
G
N
A
A
A
A
C
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
239
Blastp_CBE
92.50
97%
-90
- C1 -
-
6EMD
1
KAPCA_CRIGR
A:
[11-353]
-------------------------------------------
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
47
Blastp_CBE
92.44
99%
-81
- C1 -
-
4UJB
3
KAPCA_HUMAN
A:
[5-351]
---------------------------------------
A
A
A
A
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
230
Blastp_CBE
92.40
97%
-91
- C1 -
-
6I2D
1
KAPCA_CRIGR
A:
[11-353]
-------------------------------------------
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
46
Blastp_CBE
92.39
99%
-83
- C1 -
-
5BX6
4
KAPCA_HUMAN
A:
[6-351]
----------------------------------------
A
A
A
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
89
Blastp_CBE
92.35
99%
-86
- C1 -
-
3ZO1
7
KAPCA_BOVIN
A:
[10-351]
---------------------------------------------
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
288
Blastp_CBE
92.31
97%
-92
- C1 -
-
4C35
2
KAPCA_BOVIN
A:
[11-351]
---------------------------------------------
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
201
Blastp_CBE
92.22
97%
-89
- C1 -
-
2GNH
2
KAPCA_BOVIN
A:
[10-350]
---------------------------------------------
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
226
Blastp_CBE
92.21
97%
-84
- C1 -
-
4X6R
5
KAPCA_MOUSE
A:
[1-350]
-------------------------------------
G
N
A
A
A
A
C
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
547
HHSearch
91.99
98%
-90
- C1 -
-
5N3J
4
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
203
Blastp_CBE
91.94
98%
-90
- C1 -
-
1XH7
1
KAPCA_BOVIN
A:
[10-350]
---------------------------------------------
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
200
Blastp_CBE
91.93
97%
-86
- C1 -
-
2GNI
1
KAPCA_BOVIN
A:
[10-350]
---------------------------------------------
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
180
Blastp_CBE
91.90
98%
-88
- C1 -
-
3ZO2
4
KAPCA_BOVIN
A:
[8-351]
------------------------------------------
A
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
18
PsiBlast_PDB
91.87
99%
-88
- C1 -
-
4UJA
2
KAPCA_HUMAN
A:
[14-351]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
241
Blastp_CBE
91.80
97%
-91
- C1 -
-
6EMA
2
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
198
Blastp_CBE
91.79
97%
-91
- C1 -
-
4DG0
2
KAPCA_MOUSE
E:
[10-350]
----------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
15
PsiBlast_PDB
91.75
99%
-90
- C1 -
-
4UJ1
2
KAPCA_HUMAN
A:
[15-351]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
16
PsiBlast_PDB
91.63
99%
-91
- C1 -
-
4UJ2
2
KAPCA_HUMAN
A:
[15-351]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
218
Blastp_CBE
91.53
97%
-90
- C1 -
-
4IAF
1
KAPCA_MOUSE
A:
[21-356]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
290
Blastp_CBE
91.49
97%
-93
- C1 -
-
5NW8
2
KAPCA_CRIGR
A:
[12-351]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
37
Blastp_CBE
91.48
99%
-90
- C1 -
-
3ZO4
4
KAPCA_BOVIN
A:
[15-351]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
S
E
F
208
Blastp_CBE
91.40
97%
-92
- C1 -
-
4XW6
1
KAPCA_MOUSE
A:
[20-356]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
299
Blastp_CBE
91.39
99%
-90
- C1 -
-
4WB8
2
KAPCA_HUMAN
A:
[1-337]
--------------------------------------------------
G
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
225
Blastp_CBE
91.37
99%
-97
- C1 -
-
2UZT
1
KAPCA_BOVIN
A:
[1-336]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
191
Blastp_CBE
91.36
97%
-90
- C1 -
-
4HPU
2
KAPCA_MOUSE
E:
[12-350]
------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
232
Blastp_CBE
91.34
97%
-90
- C1 -
-
6I2B
2
KAPCA_CRIGR
A:
[7-353]
---------------------------------------
A
A
A
A
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
297
Blastp_CBE
91.27
99%
-85
- C1 -
-
4WB7
1
DNJB1_HUMAN (first)
B:
[68-405]
-------------------------------------------------
E
E
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
S
E
F
196
Blastp_CBE
91.27
97%
-91
- C1 -
-
4DH1
1
KAPCA_MOUSE
A:
[15-350]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
212
Blastp_CBE
91.19
97%
-91
- C1 -
-
4IB1
1
KAPCA_MOUSE
A:
[19-356]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
546
HHSearch
91.16
98%
-85
- C1 -
-
5N1G
4
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
88
Blastp_CBE
91.17
99%
-86
- C1 -
-
3ZO3
12
KAPCA_BOVIN
A:
[12-351]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
S
E
F
224
Blastp_CBE
91.16
99%
-91
- C1 -
-
2UZU
1
KAPCA_BOVIN
E:
[1-336]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
309
Blastp_CBE
91.15
97%
-96
- C1 -
-
4O21
1
KAPCA_MOUSE
A:
[7-342]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
195
Blastp_CBE
91.13
97%
-94
- C1 -
-
4DH3
1
KAPCA_MOUSE
A:
[15-350]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
221
Blastp_CBE
91.12
97%
-83
- C1 -
-
1JBP
2
KAPCA_MOUSE
E:
[9-350]
-------------------------------------
G
N
--------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
E
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
235
Blastp_CBE
91.10
97%
-92
- C1 -
-
6ERW
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
----
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
298
Blastp_CBE
91.09
99%
-88
- C1 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[68-405]
-------------------------------------------------
E
E
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
S
E
F
211
Blastp_CBE
91.08
97%
-91
- C1 -
-
4IB3
1
KAPCA_MOUSE
A:
[18-356]
------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
199
Blastp_CBE
91.07
97%
-88
- C1 -
-
2QCS
5
KAPCA_MOUSE
A:
[13-350]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
307
Blastp_CBE
90.97
97%
-89
- C1 -
-
2GU8
1
KAPCA_HUMAN
A:
[1-337]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
E
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
193
Blastp_CBE
90.93
97%
-91
- C1 -
-
4DH7
1
KAPCA_MOUSE
A:
[15-350]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
222
Blastp_CBE
90.92
99%
-91
- C1 -
-
2UZW
1
KAPCA_BOVIN
E:
[1-336]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
165
Blastp_CBE
90.88
97%
-88
- C1 -
-
5M0L
3
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
251
Blastp_CBE
90.83
97%
-91
- C1 -
-
5OT3
3
KAPCA_CRIGR
A:
[15-353]
------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
254
Blastp_CBE
90.82
97%
-90
- C1 -
-
5O5M
1
KAPCA_CRIGR
A:
[12-353]
--------------------------------------------
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
181
Blastp_CBE
90.82
97%
-92
- C1 -
-
3FHI
1
KAPCA_MOUSE
A:
[13-350]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
A
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
293
Blastp_CBE
90.81
97%
-84
- C1 -
-
1L3R
3
KAPCA_MOUSE
E:
[1-350]
-------------------------------------
G
N
A
A
---------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
266
Blastp_CBE
90.80
97%
-87
- C1 -
-
5N3J
4
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
262
Blastp_CBE
90.77
97%
-91
- C1 -
-
5N3O
6
KAPCA_CRIGR
A:
[16-353]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
219
Blastp_CBE
90.77
97%
-89
- C1 -
-
4IAD
1
KAPCA_MOUSE
A:
[20-356]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
184
Blastp_CBE
90.74
97%
-89
- C1 -
-
3X2U
1
KAPCA_MOUSE
A:
[19-357]
------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
213
Blastp_CBE
90.70
97%
-92
- C1 -
-
4IB0
1
KAPCA_MOUSE
A:
[20-356]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
243
Blastp_CBE
90.65
97%
-89
- C1 -
-
6EM2
2
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
214
Blastp_CBE
90.65
97%
-89
- C1 -
-
4IAZ
1
KAPCA_MOUSE
A:
[20-356]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
207
Blastp_CBE
90.60
97%
-87
- C1 -
-
6E21
1
KAPCA_MOUSE
A:
[21-356]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
192
Blastp_CBE
90.60
97%
-91
- C1 -
-
4DH8
1
KAPCA_MOUSE
A:
[15-350]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
166
Blastp_CBE
90.59
97%
-87
- C1 -
-
5M0C
3
KAPCA_CRIGR
A:
[16-353]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
306
Blastp_CBE
90.57
97%
-92
- C1 -
-
6MM5
1
KAPCA_MOUSE
E:
[3-339]
--------------------------------------------------
A
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
264
Blastp_CBE
90.57
97%
-86
- C1 -
-
5N3L
4
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
268
Blastp_CBE
90.54
97%
-87
- C1 -
-
5N3H
4
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
217
Blastp_CBE
90.51
97%
-88
- C1 -
-
4IAI
2
KAPCA_MOUSE
A:
[21-356]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
209
Blastp_CBE
90.46
97%
-90
- C1 -
-
4XW5
1
KAPCA_MOUSE
A:
[20-356]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
177
Blastp_CBE
90.46
97%
-91
- C1 -
-
4C38
4
KAPCA_BOVIN
A:
[15-351]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
S
E
F
176
Blastp_CBE
90.45
97%
-87
- C1 -
-
1RDQ
3
KAPCA_MOUSE
E:
[1-350]
-------------------------------------
G
N
A
A
A
--------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
A
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
215
Blastp_CBE
90.44
97%
-89
- C1 -
-
4IAY
1
KAPCA_MOUSE
A:
[21-356]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
182
Blastp_CBE
90.42
97%
-91
- C1 -
-
3X2W
1
KAPCA_MOUSE
A:
[19-357]
------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
237
Blastp_CBE
90.41
97%
-93
- C1 -
-
6ERT
1
KAPCA_CRIGR
A:
[16-353]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
223
Blastp_CBE
90.40
99%
-87
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[1-336]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
289
Blastp_CBE
90.38
97%
-94
- C1 -
-
4C34
3
KAPCA_BOVIN
A:
[11-351]
---------------------------------------------
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
S
E
F
152
Blastp_CBE
90.36
97%
-87
- C1 -
-
6EM7
4
KAPCA_CRIGR
A:
[13-353]
----------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
194
Blastp_CBE
90.35
97%
-91
- C1 -
-
4DH5
1
KAPCA_MOUSE
A:
[15-350]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
220
Blastp_CBE
90.29
97%
-87
- C1 -
-
4IAC
1
KAPCA_MOUSE
A:
[21-356]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
550
HHSearch
90.26
99%
-86
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[2-336]
----------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
300
Blastp_CBE
90.26
97%
-93
- C1 -
-
3PVB
1
KAPCA_MOUSE
A:
[1-345]
------------------------------------------
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
284
Blastp_CBE
90.26
97%
-88
- C1 -
-
5N1H
3
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
245
Blastp_CBE
90.26
97%
-97
- C1 -
-
6EH2
2
KAPCA_CRIGR
A:
[3-353]
------------------------------------
M
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
----
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
------------------
E
K
C
G
K
E
F
T
E
F
178
Blastp_CBE
90.24
97%
-88
- C1 -
-
4C37
2
KAPCA_BOVIN
A:
[14-351]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
S
E
F
280
Blastp_CBE
90.23
97%
-92
- C1 -
-
5N1O
2
KAPCA_CRIGR
A:
[10-353]
------------------------------------------
A
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
----
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
-
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
260
Blastp_CBE
90.22
97%
-88
- C1 -
-
5N3Q
4
KAPCA_CRIGR
A:
[15-353]
------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
216
Blastp_CBE
90.21
97%
-89
- C1 -
-
4IAK
1
KAPCA_MOUSE
A:
[20-356]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
286
Blastp_CBE
90.20
97%
-87
- C1 -
-
5N1F
3
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
261
Blastp_CBE
90.16
97%
-89
- C1 -
-
5N3P
4
KAPCA_CRIGR
A:
[15-353]
------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
263
Blastp_CBE
90.15
97%
-86
- C1 -
-
5N3M
6
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
287
Blastp_CBE
90.13
97%
-89
- C1 -
-
4C36
1
KAPCA_BOVIN
A:
[14-351]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
---
M
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
S
E
F
242
Blastp_CBE
90.08
97%
-90
- C1 -
-
6EM6
1
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
265
Blastp_CBE
90.07
97%
-87
- C1 -
-
5N3K
5
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
185
Blastp_CBE
89.97
97%
-97
- C1 -
-
2QUR
1
KAPCA_MOUSE
A:
[11-350]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
P
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
A
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
269
Blastp_CBE
89.91
97%
-87
- C1 -
-
5N3G
4
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
183
Blastp_CBE
89.86
97%
-88
- C1 -
-
3X2V
1
KAPCA_MOUSE
A:
[24-357]
-----------------------------------------------------
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
205
Blastp_CBE
89.80
97%
-93
- C1 -
-
1BKX
1
KAPCA_MOUSE
A:
[12-350]
------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
175
Blastp_CBE
89.77
97%
-89
- C1 -
-
3AMA
1
KAPCA_HUMAN
A:
[2-351]
-------------------------------------
G
N
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
258
Blastp_CBE
89.76
97%
-86
- C1 -
-
5N3S
5
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
285
Blastp_CBE
89.67
97%
-84
- C1 -
-
5N1G
4
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
204
Blastp_CBE
89.57
97%
-88
- C1 -
-
1BX6
1
KAPCA_MOUSE
A:
[12-350]
------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
238
Blastp_CBE
89.48
97%
-91
- C1 -
-
6ERS
1
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
548
HHSearch
89.38
100%
-90
- C1 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[80-405]
-------------------------------------------------------------
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
210
Blastp_CBE
89.39
97%
-82
- C1 -
-
4XW4
1
KAPCA_MOUSE
A:
[20-356]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
231
Blastp_CBE
89.38
97%
-91
- C1 -
-
6I2C
1
KAPCA_CRIGR
A:
[14-353]
-----------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
76
Blastp_CBE
89.31
98%
-89
- C1 -
-
6F14
2
KAPCA_CRIGR
A:
[9-351]
--------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
-----
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
291
Blastp_CBE
89.10
97%
-94
- C1 -
-
5N23
1
KAPCA_HUMAN
A:
[9-352]
-------------------------------------------
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
P
---------
W
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
S
E
F
189
Blastp_CBE
88.92
97%
-87
- C1 -
-
5JR7
1
KAPCA_MOUSE
A:
[13-350]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
174
Blastp_CBE
88.83
97%
-87
- C1 -
-
3AMB
1
KAPCA_HUMAN
A:
[4-351]
---------------------------------------
A
A
A
A
K
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
----
D
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
S
E
F
246
Blastp_CBE
88.41
97%
-90
- C1 -
-
6EGW
1
KAPCA_CRIGR
A:
[16-353]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
-
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
292
Blastp_CBE
88.21
97%
-87
- C1 -
-
3TNQ
1
KAPCA_MOUSE
B:
[17-350]
-----------------------------------------------------
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
190
Blastp_CBE
88.16
97%
-88
- C1 -
-
4WBB
1
KAPCA_MOUSE
B:
[14-350]
--------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
303
Blastp_CBE
87.91
97%
-106
- C1 -
-
6MM7
6
KAPCA_MOUSE
A:
[5-339]
----------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
--------
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
188
Blastp_CBE
87.87
97%
-85
- C1 -
-
5JR7
1
KAPCA_MOUSE
C:
[13-350]
-------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
301
Blastp_CBE
87.08
97%
-105
- C1 -
-
6MM8
6
KAPCA_MOUSE
C:
[3-339]
--------------------------------------------------
A
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-------------
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
302
Blastp_CBE
86.74
97%
-100
- C1 -
-
6MM7
9
KAPCA_MOUSE
D:
[4-339]
---------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
--------------
Y
E
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
270
Blastp_CBE
86.39
97%
-93
- C1 -
-
5N3F
4
KAPCA_CRIGR
A:
[10-336]
------------------------------------------
A
K
K
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
---
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
--
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
--
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
-----------------------------------
304
Blastp_CBE
85.57
97%
-101
- C1 -
-
6MM6
1
KAPCA_MOUSE
E:
[7-339]
------------------------------------------------------
F
L
A
K
A
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
----
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
---------------
E
E
E
I
R
---
V
----
I
------
N
------
E
K
C
G
K
E
F
T
E
F
571
Fugue
65.75
90%
-3
- C1 -
-
1CDK
2
KAPCA_PIG
A:
[8-350]
------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
------
H
---
L
----
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G-
N
H
----
F
A
M
K
I
L
D
K
Q
K
V
V
K
-L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
AV-----
N
---
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
-S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q-
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
KGRT-------------
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
-KGY-------
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-Y
P
P
F
----
F
A
D
--QP
I
Q
-----
I
Y
E
K
I
V
S
G
KVRFPS---------------
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
---TTD
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
VSI------------
N
------
E
K
C
G
K
E
F
S
E
F
551
HHSearch
58.44
42%
-44
- C1 -
-
2JDO
2
AKT2_HUMAN
A:
[6-334]
-------------------------------------------------------------------------
K
-
V
T
M
----
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
---
R
---
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
--
G
-----
I
S
DGA-
T
----
M
K
---------
T
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
R
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
---
I
---
T
P
-----------------------
556
HHSearch
55.09
39%
-33
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[3-321]
----------------------------------------------------------------------------
K
I
----
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
-
N
Q
F
----
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L-
A
W
---
E
---
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
-----
M
L
GDA-
K
----
T
N
---------
E
-
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
-------
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
K
P
R
---
L
---
S
F
------
A
DRALIN
S
M
D
Q
N
M
F
R
N
F
315
Blastp_CBE
54.94
45%
-10
- C1 -
-
6BDL
1
KGP1_HUMAN
B:
[33-342]
-----------------------------------------------------------------------------
L
----
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
---
L
---
K
S--
E
E
-
S
K
T
----
F
A
M
K
I
L
K
K
R
H
I
V
D
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
--
G
A
---
H
---
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
-
G
-
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
-----------------------------
K
---
K
--
I
GF---
G
K
----
K
----
T
W
---------
T
-
F
C
----
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
----
S
G
P
D
P
--
M
K
-----
T
Y
N
I
I
L
R
G
ID----
M
--
I
E
--
F
P
-----
K
K
--
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
-
N
L
-
K
-
N
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
-
S
-
F
P
E
D
N
D
E
---
P
---
P
P
------
D
------
D
N
S
G
------
310
Blastp_CBE
54.65
45%
-6
- C1 -
-
6C0T
3
KGP1_HUMAN
A:
[33-342]
-----------------------------------------------------------------------------
L
----
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
---
L
---
K
S--
E
E
-
S
K
T
----
F
A
M
K
I
L
K
K
R
H
I
V
D
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
--
G
A
---
H
---
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
-
G
-
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
-----------------------------
K
---
K
--
I
GF---
G
K
----
K
----
T
W
---------
T
-
F
C
----
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
----
S
G
P
D
P
--
M
K
-----
T
Y
N
I
I
L
R
G
ID----
M
--
I
E
--
F
P
-----
K
K
--
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
-
N
L
-
K
-
N
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
-
S
-
F
P
E
D
N
D
E
---
P
---
P
P
------
D
------
D
N
S
G
------
316
Blastp_CBE
54.41
45%
-7
- C1 -
-
6BDL
1
KGP1_HUMAN
A:
[33-342]
-----------------------------------------------------------------------------
L
----
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
---
L
---
K
S--
E
E
-
S
K
T
----
F
A
M
K
I
L
K
K
R
H
I
V
D
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
--
G
A
---
H
---
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
-
G
-
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
-----------------------------
K
---
K
--
I
GF---
G
K
----
K
----
T
W
---------
T
-
F
C
----
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
----
S
G
P
D
P
--
M
K
-----
T
Y
N
I
I
L
R
G
ID----
M
--
I
E
--
F
P
-----
K
K
--
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
-
N
L
-
K
-
N
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
-
S
-
F
P
E
D
N
D
E
---
P
---
P
P
------
D
------
D
N
S
G
------
517
Blastp_CBE
53.26
38%
-104
- C1 -
-
2R7B
2
PDPK1_HUMAN
A:
[33-306]
----------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
-----------------------------
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
519
Blastp_CBE
52.80
38%
-67
- C1 -
-
2BIY
8
PDPK1_HUMAN
A:
[30-303]
----------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
SPESK
Q
A
----
R
----
A
N
---------
A
-
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
234
Blastp_CBE
52.79
97%
31
- C1 -
-
6ESA
4
KAPCA_CRIGR
A:
[13-353]
---------------------------------------------
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
538
Blastp_CBE
52.68
38%
-73
- C1 -
-
1UU9
8
PDPK1_HUMAN
A:
[1-282]
---------------------------------------------------------------------
P
Q
P
R
K
-
K
R
P
----
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S--------------------------
N
-
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
444
Blastp_CBE
52.66
39%
-40
- C1 -
-
5F9E
1
KPCT_HUMAN
A:
[15-306]
-------------------------------------------------------------------------
K
-
L
K
I
----
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
-
N
Q
F
----
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L-
A
W
---
E
---
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
MLG--
D
A
----
K
----
T
N
---------
E
-
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
-------
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
------------------------------------------
439
Blastp_CBE
52.66
39%
-43
- C1 -
-
4RA5
1
B:
[4-314]
-----------------------------------------------------------------------------
I
----
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
-
N
Q
F
----
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L-
A
W
---
E
---
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
MLG--
D
A
----
K
----
T
N
---------
E
-
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
-------
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
------------------------------------------
443
Blastp_CBE
52.59
39%
-43
- C1 -
-
5F9E
1
B:
[16-338]
---------------------------------------------------------------------------
L
K
I
----
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
-
N
Q
F
----
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L-
A
W
---
E
---
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
MLG--
D
A
----
K
----
T
N
---------
E
-
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
-------
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
------------------------------------------
514
Blastp_CBE
52.44
36%
-38
- C1 -
-
6BXI
1
STK38_HUMAN
B:
[5-332]
-----------------------------------------------------------------------------
L
----
E
D
F
E
S
L
K
V
I
G
R
G
-
A
F
G
E
V
R
L
V
Q
---
K
---
K
---
D
T
-
G
H
V
----
Y
A
M
K
I
L
R
K
A
D
M
L
E
K
-
E
Q
V
G
H
I
R
A
E
R
D
I
L
-
V
--
E
A
---
D
---
S
L
W
V
V
K
M
F
Y
S
F
Q
D
K
L
-
N
L
Y
L
I
M
E
F
L
P
G
G
D
M
M
T
L
L
M
K
K
-
D
-
T
L
T
E
E
E
T
Q
F
Y
I
A
E
T
V
L
A
I
D
S
I
H
Q
-
L
G
F
I
H
R
D
I
K
P
D
N
L
L
L
D
-
S
K
G
H
V
K
L
S
D
F
G
L
C
TGLKKAHRTEFYRNLNHSLPSDFTFQNMN
S
---
K
--
R
-----
K
A
----
E
----
T
W
KRNRRQLAF
S
-
T
V
----
G
T
P
D
Y
I
A
P
E
V
F
M
Q
T
---
G
-----
Y
N
K
L
C
D
W
W
S
L
G
V
I
M
Y
E
M
L
I
G
Y
-
P
P
F
----
C
S
E
T
P
--
Q
E
-----
T
Y
K
K
V
M
N
W
------
K
ET
L
T
--
F
P
-----
P
E
VP
I
S
E
K
A
K
D
L
I
L
R
F
C
-
C
E
W
E
H
--
R
I
G
----
A
-
P
G
V
E
E
I
K
S
N
S
F
F
E
G
V
D
---
W
E
H
I
R
E
R
P
--
A
A
I
S
I
E
I
K
S
I
D
D
T
S
N
F
D
-
E
-
F
--------------------------------------
440
Blastp_CBE
52.32
39%
-44
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[4-292]
-----------------------------------------------------------------------------
I
----
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
-
N
Q
F
----
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L-
A
W
---
E
---
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
MLG--
D
A
----
K
----
T
N
---------
E
-
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
-------
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
------------------------------------------
252
Blastp_CBE
52.32
97%
34
- C1 -
-
5OL3
2
KAPCA_CRIGR
A:
[13-353]
---------------------------------------------
G
-
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
----
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
-
G
N
H
----
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
---
N
---
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
-
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
---
V
---
S
I
------
N
------
E
K
C
G
K
E
F
T
E
F
515
Blastp_CBE
51.79
36%
-36
- C1 -
-
6BXI
1
STK38_HUMAN
A:
[5-332]
-----------------------------------------------------------------------------
L
----
E
D
F
E
S
L
K
V
I
G
R
G
-
A
F
G
E
V
R
L
V
Q
---
K
---
K
---
D
T
-
G
H
V
----
Y
A
M
K
I
L
R
K
A
D
M
L
E
K
-
E
Q
V
G
H
I
R
A
E
R
D
I
L
-
V
--
E
A
---
D
---
S
L
W
V
V
K
M
F
Y
S
F
Q
D
K
L
-
N
L
Y
L
I
M
E
F
L
P
G
G
D
M
M
T
L
L
M
K
K
-
D
-
T
L
T
E
E
E
T
Q
F
Y
I
A
E
T
V
L
A
I
D
S
I
H
Q
-
L
G
F
I
H
R
D
I
K
P
D
N
L
L
L
D
-
S
K
G
H
V
K
L
S
D
F
G
L
C
TGLKKAHRTEFYRNLNHSLPSDFTFQNMN
S
---
K
--
R
-----
K
A
----
E
----
T
W
KRNRRQLAF
S
-
T
V
----
G
T
P
D
Y
I
A
P
E
V
F
M
Q
T
---
G
-----
Y
N
K
L
C
D
W
W
S
L
G
V
I
M
Y
E
M
L
I
G
Y
-
P
P
F
----
C
S
E
T
P
--
Q
E
-----
T
Y
K
K
V
M
N
W
------
K
ET
L
T
--
F
P
-----
P
E
VP
I
S
E
K
A
K
D
L
I
L
R
F
C
-
C
E
W
E
H
--
R
I
G
----
A
-
P
G
V
E
E
I
K
S
N
S
F
F
E
G
V
D
---
W
E
H
I
R
E
R
P
--
A
A
I
S
I
E
I
K
S
I
D
D
T
S
N
F
D
-
E
-
F
--------------------------------------
442
Blastp_CBE
51.53
39%
-43
- C1 -
-
4Q9Z
1
KPCT_HUMAN
A:
[4-292]
-----------------------------------------------------------------------------
I
----
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
-
N
Q
F
----
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L-
A
W
---
E
---
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
MLG--
D
A
----
K
----
T
N
---------
E
-
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
-------
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
------------------------------------------
565
HHSearch
51.51
39%
-50
- C1 -
-
1XJD
1
A:
[16-333]
-----------------------------------------------------------------------------
I
----
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
-
N
Q
F
----
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L-
A
W
---
E
---
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
-----
M
L
GDA-
K
----
T
N
---------
T
-
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
-------
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
---------------------------------------------------
Q
N
M
F
R
N
F
557
HHSearch
51.28
41%
-50
- C1 -
-
3TXO
1
KPCL_HUMAN
A:
[23-344]
----------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
---
V
---
K
---
E
T
-
G
D
L
----
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
-
S
--
L
A
R--
N
---
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
-
R
-
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
-----------------------------
K
---
E
--
G
-----
I
------------------------
C
----
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
---
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
-
A
P
F
----
E
A
E
N
E
--
D
D
-----
L
F
E
A
I
L
N
D
------
E
--
V
V
--
Y
P
-----
T
W
--
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
-
S
L
-
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
-
P
D
F
I
K
E
E
P
V
---
L
---
T
P
IDEGHL
P
------
M
I
N
Q
D
E
F
R
N
F
543
Blastp_CBE
50.74
38%
-80
- C1 -
-
2PE0
4
PDPK1_HUMAN
A:
[7-280]
----------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S----------------------------
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
563
HHSearch
50.67
36%
-62
- C1 -
-
6ED6
1
ROCK2_HUMAN
A:
[86-411]
----------------------------------------------------------------------------
K
A
----
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
-
Q
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
---
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
GMVH
C
D
---------
T
-
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
----F----
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
--
N
S
LC
F
P
ED---
A
E
--
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
--------
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
-
D
-
I
----------E--
T
F
PIPKA-
F
------
V
G
N
Q
L
P
F
I
G
F
541
Blastp_CBE
50.51
38%
-80
* C1 *
-
2PE2
9
PDPK1_HUMAN
A:
[7-280]
----------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S----------------------------
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
544
Blastp_CBE
50.39
38%
-81
- C1 -
-
1Z5M
4
PDPK1_HUMAN
A:
[7-280]
----------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S----------------------------
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
542
Blastp_CBE
49.80
38%
-78
- C1 -
-
2PE1
5
PDPK1_HUMAN
A:
[7-280]
----------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S----------------------------
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
516
Blastp_CBE
49.42
38%
-77
- C1 -
-
3ION
1
PDPK1_HUMAN
A:
[33-306]
----------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S-----------------------------
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
358
Blastp_CBE
49.39
45%
-40
- C1 -
-
6HHJ
1
AKT1_HUMAN
A:
[147-440]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----
D
G
----
A
----
T
M
K--------
T
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
----------------------------------------
545
Blastp_CBE
48.62
38%
-65
- C1 -
-
3PWY
1
PDPK1_HUMAN
A:
[32-305]
----------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
C
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
SP-------------------------
S
-
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
S
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
365
Blastp_CBE
48.57
42%
-41
- C1 -
-
3TXO
1
A:
[23-330]
----------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
---
V
---
K
---
E
T
-
G
D
L
----
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
-
S
L-
A
R
---
N
---
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
-
R
-
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
-----------------------------
K
---
E
GI-------------------------------
C
----
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
---
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
-
A
P
F
----
E
A
E
N
E
--
D
D
-----
L
F
E
A
I
L
N
D
------
E
--
V
V
--
Y
P
-----
T
W
--
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
-
S
L
T
Q
-
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
-
F
I
K
E
E
P
V
---
L
---
P
I
------
D
------
E
---------
518
Blastp_CBE
48.15
38%
-70
- C1 -
-
3NAX
1
PDPK1_HUMAN
A:
[29-302]
----------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
SPESK
Q
A
----
R
-------------------------
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
572
Fugue
48.14
34%
6
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILIC
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
-----
H
R
----
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
L
---
K
---
N
A
-
D
K
V
----
F
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
--
N
G
---
D
---
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
-
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
-
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
H
I
R
L
A
D
F
G
S
C
-----------------------------
L
---
K
--
L
-----
M
E
DGTV
Q
----
S
S
---------
V
-
A
V
----
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
---
E
GGKGR
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
----
Y
A
E
S
L
--
V
E
-----
T
Y
G
K
I
M
N
H
------
K
--
E
R
--
F
Q
FPTQV
T
D
--
V
S
E
N
A
K
D
L
I
R
R
L
I
-
C
S
R
E
H
--
R
L
G
-
Q
----
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
R
N
--
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
-
V
-
D
S
G
H
H
L
P
---
F
VGF
T
Y
------
T
------
S
S
C
V
L
S
D
R
S
C
562
HHSearch
47.53
45%
-50
- C1 -
-
4EJN
3
AKT1_HUMAN
A:
[144-438]
-------------------------------------------------------------------------
R
-
V
T
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
V
--------------
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
--
G
-----
I
K
----------
K
---------
T
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
-------------------------------------------
414
Blastp_CBE
46.85
37%
-41
- C1 -
-
4DC2
1
KPCI_MOUSE
A:
[49-353]
---------------------------------------------------------------------------
L
G
L
----
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
-
D
R
I
----
Y
A
M
R
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
---
N
---
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
EGL
R
--
P
-----
G
D
----
T
----
T
S
---------
T
-
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DIVG
S
--------NTEDY
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
------------------------------------------
529
Blastp_CBE
46.39
35%
16
- C1 -
-
4L6Q
1
ROCK2_HUMAN
A:
[51-379]
---------------------------------------------------------
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
-
R
G
L
QMKA
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
-
Q
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
----
G
M
---------
V
-
H
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGF-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
--
N
S
--
L
C
-----
F
P
--
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
----------------------------------
325
Blastp_CBE
46.20
43%
-42
- C1 -
-
3D0E
1
AKT2_HUMAN
A:
[4-307]
-----------------------------------------------------------------------------
M
----
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
---
R
---
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
S
-----
D
G
----
A
----
T
M
---------
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
R
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
----------------------------------------
323
Blastp_CBE
46.18
43%
-46
- C1 -
-
3E87
1
AKT2_HUMAN
A:
[4-308]
-----------------------------------------------------------------------------
M
----
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
---
R
---
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
S
-----
D
G
----
A
----
T
M
---------
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
R
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
----------------------------------------
322
Blastp_CBE
46.12
43%
-45
- C1 -
-
3E87
1
AKT2_HUMAN
B:
[4-308]
-----------------------------------------------------------------------------
M
----
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
---
R
---
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
S
-----
D
G
----
A
----
T
M
---------
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
R
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
----------------------------------------
528
Blastp_CBE
45.89
35%
16
- C1 -
-
4L6Q
1
ROCK2_HUMAN
B:
[51-379]
---------------------------------------------------------
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
-
R
G
L
QMKA
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
-
Q
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
----
G
M
---------
V
-
H
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGF-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
--
N
S
--
L
C
-----
F
P
--
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
----------------------------------
361
Blastp_CBE
45.88
45%
-40
- C1 -
-
6HHG
1
AKT1_HUMAN
A:
[147-440]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
----------------------
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
----------------
T
M
K--------
T
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
----------------------------------------
353
Blastp_CBE
45.83
42%
-20
- C1 -
-
3HDM
1
SGK1_HUMAN
A:
[29-320]
---------------------------------------------------------------------
P
S
S
N
P
H
A
K
P
----
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
---
K
---
A
E
-
E
V
F
----
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
--
N
V
---
K
---
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
-
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
N
IEH--
N
S
----
T
----
T
S
---------
T
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
----
Y
S
R
N
T
--
A
E
-----
M
Y
D
N
I
L
N
K
------
P
--
L
Q
--
L
K
-----
P
N
--
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
--
A
-
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
--------------------------------------------------
357
Blastp_CBE
45.77
45%
-40
- C1 -
-
6S9W
1
?
A:
[147-440]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----------
A
----
T
M
K--------
T
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
----------------------------------------
359
Blastp_CBE
45.63
45%
-38
- C1 -
-
6HHI
1
AKT1_HUMAN
A:
[147-440]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
------------------
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
----------------
T
M
K--------
T
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
----------------------------------------
354
Blastp_CBE
45.49
42%
-15
- C1 -
-
2R5T
1
SGK1_HUMAN
A:
[29-320]
---------------------------------------------------------------------
P
S
S
N
P
H
A
K
P
----
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
---
K
---
A
E
-
E
V
F
----
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
--
N
V
---
K
---
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
-
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
N
IEH--
N
S
----
T
----
T
S
---------
T
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
----
Y
S
R
N
T
--
A
E
-----
M
Y
D
N
I
L
N
K
------
P
--
L
Q
--
L
K
-----
P
N
--
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
--
A
-
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
--------------------------------------------------
416
Blastp_CBE
45.45
41%
-43
- C1 -
-
3PFQ
1
KPCB_RAT
A:
[340-633]
-----------------------------------------------------------------------------
L
----
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
S
E
---
R
---
K
---
G
T
-
D
E
L
----
Y
A
V
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
A
--
L
P
---
G
K--
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
-
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
IW---
D
G
----
V
----
T
T
---------
K
-
F
C
----
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
---
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
-
A
P
F
----
E
G
E
D
E
--
D
E
-----
L
F
Q
S
I
M
E
H
------
N
--
V
A
--
Y
P
-----
K
S
--
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
--
R
L
G
-
C
G
-
P
-
E
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
S
G
-
R
N
A
E
N
F
D
-
R
-
F
--------------------------------------
363
Blastp_CBE
45.39
45%
-42
- C1 -
-
4EJN
3
AKT1_HUMAN
A:
[147-438]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
V
--------------
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
------------------K--------
T
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
-------------------------------------------
366
Blastp_CBE
45.37
40%
-47
- C1 -
-
4RA4
1
KPCA_HUMAN
A:
[15-339]
------------------------------------------------------------------------
D
R
-
V
K
L
----
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
A
D
---
R
---
K
---
G
T
-
E
E
L
----
Y
A
I
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
A
--
L
L
---
D
K--
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
-
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
HM
M
-----
D
G
----
V
----
T
T
---------
R
-
F
C
----
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
---
P
-----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
-
P
P
F
----
D
G
E
D
E
--
D
E
-----
L
F
Q
S
I
M
E
H
------
N
--
V
S
--
Y
P
-----
K
S
--
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
--
R
L
G
-
C
G
-
P
-
E
G
E
R
D
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
V
S
G
K
G
-
A
E
N
F
D
-
K
-
F
--------------------------------------
324
Blastp_CBE
45.06
43%
-42
- C1 -
-
3D0E
1
AKT2_HUMAN
B:
[4-307]
-----------------------------------------------------------------------------
M
----
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
---
R
---
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
S
-----
D
G
----
A
----
T
M
---------
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
R
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
-
D
----------------------------------------
352
Blastp_CBE
44.64
42%
-14
- C1 -
-
3HDN
1
SGK1_HUMAN
A:
[29-316]
---------------------------------------------------------------------
P
S
S
N
P
H
A
K
P
----
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
---
K
---
A
E
-
E
V
F
----
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
--
N
V
---
K
---
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
-
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
N
IEH--
N
S
----
T
----
T
S
---------
T
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
----
Y
S
R
N
T
--
A
E
-----
M
Y
D
N
I
L
N
K
------
P
--
L
Q
--
L
K
-----
P
N
--
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
--
A
-
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
------------------------------------------------------
332
Blastp_CBE
44.41
44%
-38
- C1 -
-
3QKK
1
AKT1_HUMAN
A:
[5-309]
-------------------------------------------------------------------------
R
-
V
T
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----
D
G
----
A
----
T
M
---------
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
----------------------------------------
344
Blastp_CBE
44.24
45%
-39
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-305]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----
D
G
----
A
----
T
M
---------
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
----------------------------------------
327
Blastp_CBE
44.08
44%
-34
- C1 -
-
4EKL
1
AKT1_HUMAN
A:
[5-306]
-------------------------------------------------------------------------
R
-
V
T
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----
D
G
----
A
----
T
M
---------
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
----------------------------------------
330
Blastp_CBE
44.02
44%
-39
- C1 -
-
3QKM
1
AKT1_HUMAN
A:
[5-306]
-------------------------------------------------------------------------
R
-
V
T
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----
D
G
----
A
----
T
M
---------
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
----------------------------------------
364
Blastp_CBE
43.95
45%
-48
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[161-452]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
------------------
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
--------------------------------------------------------------------------
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
-------------------------------------------
448
Blastp_CBE
43.89
38%
-50
- C1 -
-
1XJD
1
A:
[16-335]
-----------------------------------------------------------------------------
I
----
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
-
N
Q
F
----
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L-
A
W
---
E
---
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
N-
M
-----
L
G
----
D
----
A
K
---------
T
N
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
-------
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
------------
N
F
D
K
E
-
F
L
-------------
F
------
A
----------------
362
Blastp_CBE
43.75
45%
-49
- C1 -
-
6HHF
1
AKT1_HUMAN
A:
[147-439]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
----------------------
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
-------------------------------------------
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
------------------------------------------
355
Blastp_CBE
43.71
45%
-56
- C1 -
-
3O96
1
AKT1_HUMAN
A:
[150-432]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
V
A
-----------
N
R
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
----------------------------------------
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
----------------------------------------------------
540
Blastp_CBE
43.00
38%
-56
- C1 -
-
1H1W
9
PDPK1_HUMAN
A:
[2-283]
---------------------------------------------------------------------
P
Q
P
R
K
-
K
R
P
----
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
SP---------
A
----
R
A
---------
N
-
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
539
Blastp_CBE
42.90
38%
-60
- C1 -
-
1UVR
8
PDPK1_HUMAN
A:
[2-283]
---------------------------------------------------------------------
P
Q
P
R
K
-
K
R
P
----
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
-
S
R
E
----
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
--
R
L
---
D
---
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
SP---------
A
----
R
A
---------
N
-
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
-
C
E
-
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------
489
Blastp_CBE
42.78
36%
15
- C1 -
-
5HVU
1
ROCK1_HUMAN
B:
[50-375]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
D----
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
559
HHSearch
42.71
41%
-19
- C1 -
-
4OTH
1
A:
[7-305]
------------------------------------------------------------------------
S
P
-
L
T
L
----
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
---
R
---
P
S
-
G
E
L
----
F
A
I
K
A
L
K
K
G
D
I
V
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
--
A
V
TSA
G
---
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
-----------------------------
K
------------------------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
----
P
G
D
D
E
--
E
E
-----
V
F
D
S
I
V
N
D
------
E
--
V
R
--
Y
P
-----
R
F
--
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
-
S
S
-
E
-
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
-
E
----------------------------------------
356
Blastp_CBE
42.53
45%
-20
- C1 -
-
6S9X
1
?
A:
[147-440]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
I
------------------
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----------------------------
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-
E
----------------------------------------
425
Blastp_CBE
42.34
39%
-41
- C1 -
-
3A8W
1
KPCI_HUMAN
B:
[3-310]
-----------------------------------------------------------------------
M
D
P
-
L
G
L
----
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
-
D
R
I
----
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
---
N
---
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
G--------
G
----
D
----
T
T
---------
S
-
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DI-----------EDY--
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
------------------------------------------
360
Blastp_CBE
42.28
45%
-20
- C1 -
-
6HHH
1
AKT1_HUMAN
A:
[147-439]
-----------------------------------------------------------------------------
M
----
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
-
G
R
Y
----
Y
A
M
K
I
L
K
K
E
V
---------------
R
V
L
-
Q
--
N
S
---
R
---
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
G-------------------------------------
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
------------------------------------------
484
Blastp_CBE
41.94
36%
19
- C1 -
-
5UZJ
1
ROCK1_HUMAN
A:
[50-380]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
-----
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----GY---
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
483
Blastp_CBE
41.86
36%
20
- C1 -
-
5UZJ
1
ROCK1_HUMAN
B:
[50-381]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
----------
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
432
Blastp_CBE
41.78
40%
-37
- C1 -
-
5LI9
13
KPCI_HUMAN
A:
[5-307]
-----------------------------------------------------------------------------
L
----
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
-
D
R
I
----
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
---
N
---
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
-
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D------------EDY--
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
------------------------------------------
506
Blastp_CBE
41.75
36%
31
- C1 -
-
2ETR
1
ROCK1_HUMAN
B:
[50-375]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
373
Blastp_CBE
41.74
40%
19
- C1 -
-
4NUS
1
KS6A3_HUMAN
A:
[31-322]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
-------
K
---
I
S
-
G
S
D
ARQL
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
IDH--
E
K
----
K
----
A
Y
---------
S
-
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
------
T
F
Y
F
D
------------------------------------------
536
Blastp_CBE
41.71
35%
13
- C1 -
-
6ED6
1
ROCK2_HUMAN
B:
[64-396]
---------------------------------------------------------
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
-
R
G
L
QMKA
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
-
Q
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----------------------------------
G
T
P
D
Y
I
S
P
E
V
L
K
S
----------
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
--
N
S
--
L
C
-----
F
P
--
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
----------------------------------
510
Blastp_CBE
41.71
36%
32
- C1 -
-
2ESM
1
ROCK1_HUMAN
B:
[50-375]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
446
Blastp_CBE
41.69
40%
-18
- C1 -
-
4OTH
1
A:
[11-305]
-----------------------------------------------------------------------------
L
----
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
---
R
---
P
S
-
G
E
L
----
F
A
I
K
A
L
K
K
G
D
I
V
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
--
A
V
---
T
SAG
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
-----------------------------
K
------------------------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
----
P
G
D
D
E
--
E
E
-----
V
F
D
S
I
V
N
D
------
E
--
V
R
--
Y
P
-----
R
F
--
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
-
S
S
-
E
-
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
-
E
----------------------------------------
495
Blastp_CBE
41.56
36%
35
- C1 -
-
4YVC
1
ROCK1_HUMAN
B:
[50-381]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
485
Blastp_CBE
41.53
36%
34
- C1 -
-
5KKT
1
ROCK1_HUMAN
B:
[50-379]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
537
Blastp_CBE
41.51
35%
23
- C1 -
-
6ED6
1
ROCK2_HUMAN
A:
[64-396]
---------------------------------------------------------
K
N
I
D
N
F
L
N
R
Y
E
K
I
V
K
K
I
-
R
G
L
QMKA
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
-
Q
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
----
G
M
---------
V
-
H
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
----F----
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
--
N
S
--
L
C
-----
F
P
--
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
----------------------------------
508
Blastp_CBE
41.48
36%
35
- C1 -
-
2ETK
1
ROCK1_HUMAN
B:
[50-375]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
493
Blastp_CBE
41.43
36%
30
- C1 -
-
4YVE
1
ROCK1_HUMAN
B:
[50-380]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
494
Blastp_CBE
41.34
36%
17
- C1 -
-
4YVE
1
ROCK1_HUMAN
A:
[50-381]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----GY---
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
487
Blastp_CBE
41.33
36%
34
- C1 -
-
5KKS
1
ROCK1_HUMAN
B:
[50-378]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
447
Blastp_CBE
41.32
40%
-13
- C1 -
-
4OTG
1
A:
[11-336]
-----------------------------------------------------------------------------
L
----
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
---
R
---
P
S
-
G
E
L
----
F
A
I
K
A
L
K
K
G
D
I
V
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
--
A
V
---
T
SAG
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
-----------------------------
K
---
E
--
G
-----
M
G
YGD-
R
----
T
----------
S
-
F
C
----
G
T
P
E
F
L
A
P
E
V
L
T
D
T
---
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
----
P
G
D
D
E
--
E
E
-----
V
F
D
S
I
V
N
D
------
E
--
V
R
--
Y
P
-----
R
F
--
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
-
S
S
-
E
-
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
-
E
----------------------------------------
504
Blastp_CBE
41.28
36%
35
- C1 -
-
3D9V
1
ROCK1_HUMAN
B:
[50-375]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
372
Blastp_CBE
41.24
40%
21
- C1 -
-
4NW5
1
KS6A3_HUMAN
A:
[31-322]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
-------
K
---
I
S
-
G
S
D
ARQL
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
IDH--
E
K
----
K
----
A
Y
---------
S
-
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
------------------------------------------
490
Blastp_CBE
41.15
36%
36
- C1 -
-
5HVU
1
ROCK1_HUMAN
A:
[50-381]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
428
Blastp_CBE
41.15
40%
-38
- C1 -
-
3ZH8
5
KPCI_HUMAN
B:
[4-336]
-----------------------------------------------------------------------------
L
----
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
-
D
R
I
----
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
---
N
---
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
-
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DIVG---------TEDY-
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
------------------------------------------
492
Blastp_CBE
41.12
36%
31
- C1 -
-
5BML
1
ROCK1_HUMAN
A:
[50-380]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
------
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
512
Blastp_CBE
41.00
36%
22
- C1 -
-
6E9W
1
ROCK1_HUMAN
B:
[78-409]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
-------
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
----GY---
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
--
N
S
--
L
T
-----
F
P
--
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
445
Blastp_CBE
40.95
40%
-20
- C1 -
-
4OTI
1
A:
[11-305]
-----------------------------------------------------------------------------
L
----
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
---
R
---
P
S
-
G
E
L
----
F
A
I
K
A
L
K
K
G
D
I
V
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
--
A
V
---
T
SAG
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
-------------------------------------------------------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
----
P
G
D
D
E
--
E
E
-----
V
F
D
S
I
V
N
D
------
E
--
V
R
--
Y
P
-----
R
F
--
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
-
S
S
-
E
-
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
-
E
----------------------------------------
491
Blastp_CBE
40.93
36%
35
- C1 -
-
5BML
1
ROCK1_HUMAN
B:
[50-378]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
496
Blastp_CBE
40.77
36%
37
- C1 -
-
4YVC
1
ROCK1_HUMAN
A:
[50-403]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
------
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
511
Blastp_CBE
40.73
36%
36
- C1 -
-
2ESM
1
ROCK1_HUMAN
A:
[50-375]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
371
Blastp_CBE
40.71
40%
22
- C1 -
-
4NW6
1
KS6A3_HUMAN
A:
[31-322]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
-------
K
---
I
S
-
G
S
D
ARQL
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
IDH--
E
K
----
K
----
A
Y
---------
S
-
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
------------------------------------------
509
Blastp_CBE
40.44
36%
37
- C1 -
-
2ETK
1
ROCK1_HUMAN
A:
[50-375]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
431
Blastp_CBE
40.41
40%
-39
- C1 -
-
5LIH
3
KPCI_HUMAN
A:
[4-306]
-----------------------------------------------------------------------------
L
----
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
-
D
R
I
----
Y
A
M
K
V
V
K
K
E
L
V
--------
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
---
N
---
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
-
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DIV----------NTEDY
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
------------------------------------------
426
Blastp_CBE
40.36
39%
-39
- C1 -
-
3A8W
1
KPCI_HUMAN
A:
[3-310]
-----------------------------------------------------------------------
M
D
P
-
L
G
L
----
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
-
D
R
I
----
Y
A
M
K
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
---
N
---
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
-
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DI-----------EDY--
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
------------------------------------------
488
Blastp_CBE
40.19
36%
36
- C1 -
-
5KKS
1
ROCK1_HUMAN
A:
[50-380]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
505
Blastp_CBE
40.02
36%
37
- C1 -
-
3D9V
1
ROCK1_HUMAN
A:
[50-375]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
507
Blastp_CBE
39.86
36%
38
- C1 -
-
2ETR
1
ROCK1_HUMAN
A:
[50-375]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
420
Blastp_CBE
39.68
39%
-42
- C1 -
-
6ILZ
1
KPCI_HUMAN
E:
[12-312]
-------------------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
----------
D
R
I
----
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
---
N
---
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
-
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DI-----------DY---
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
------------------------------------------
513
Blastp_CBE
39.60
36%
24
- C1 -
-
6E9W
1
ROCK1_HUMAN
A:
[78-432]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----Y----
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
--
N
S
--
L
T
-----
F
P
--
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
465
Blastp_CBE
39.45
36%
39
- C1 -
-
2V55
1
ROCK1_HUMAN
C:
[50-378]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
422
Blastp_CBE
39.42
39%
-35
- C1 -
-
6ILZ
1
KPCI_HUMAN
A:
[11-310]
------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
----------
D
R
I
----
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
---
N
---
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
-
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DIV----------DY---
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
------------------------------------------
413
Blastp_CBE
39.10
40%
-5
- C1 -
-
6G77
2
KS6A6_HUMAN
A:
[30-307]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
-
G
Q
L
----
Y
A
M
K
V
L
-
K
K
A
S
L
K
V
-
R
D
--------
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
VDQ--
E
K
----
K
----
A
Y
---------
S
-
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
N
E
-----
T
M
N
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
----
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------
466
Blastp_CBE
39.03
36%
40
- C1 -
-
2V55
1
ROCK1_HUMAN
A:
[50-404]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
435
Blastp_CBE
38.95
41%
-18
- C1 -
-
4CRS
1
A:
[10-312]
----------------------------------------------------------------------------
N
L
----
Q
D
F
R
C
C
A
V
L
L
R
G
-
H
F
G
K
V
L
L
A
E
---
Y
---
K
---
N
T
-
N
E
M
----
F
A
I
K
A
L
K
K
G
D
I
V
A
R
-
D
E
V
D
S
L
M
C
E
K
R
I
F
-
E
--
T
V
---
N
SVR
H
P
F
L
V
N
L
F
A
C
F
Q
T
K
E
-
H
V
C
F
V
M
E
Y
A
A
G
G
D
L
M
M
H
I
H
---
T
-
D
V
F
E
P
R
A
V
F
Y
A
A
C
V
V
L
G
L
Q
Y
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
F
V
K
I
A
D
F
G
L
C
-----------------------------
K
---
E
--
G
-----
M
G
YGD-
R
----
T
----------
S
-
F
C
----
G
T
P
E
F
L
A
P
E
V
L
T
E
T
---
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
I
Y
E
M
L
V
G
E
-
S
P
F
----
P
G
D
D
E
--
E
E
-----
V
F
D
S
I
V
N
D
------
E
--
V
R
--
Y
P
-----
R
F
--
L
S
T
E
A
I
S
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
-
A
S
-
E
-
K
D
A
E
D
V
K
K
H
P
F
F
R
L
I
D
---
W
S
A
L
M
D
K
K
V
K
P
P
F
I
P
T
I
R
G
R
E
D
V
S
N
F
D
-
D
----------------------------------------
421
Blastp_CBE
38.87
39%
-39
- C1 -
-
6ILZ
1
KPCI_HUMAN
C:
[11-312]
------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
----------
D
R
I
----
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
---
N
---
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
-
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DI-----------DY---
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
------------------------------------------
486
Blastp_CBE
38.85
36%
39
- C1 -
-
5KKT
1
ROCK1_HUMAN
A:
[50-403]
---------------------------------------------------------
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
-
R
D
L
RMKA
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
-
R
K
V
----
Y
A
M
K
L
L
S
K
F
E
M
I
K
-----
A
F
F
W
E
E
R
D
I
M
-
A
--
F
A
---
N
---
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
--
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
----
G
M
---------
V
-
R
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
-----
D
----
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
--
R
E
V
-
R
L
G
R
-
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
----------------------------------
417
Blastp_CBE
38.69
40%
-19
- C1 -
-
6G78
1
KS6A6_HUMAN
B:
[30-307]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
-
G
Q
L
----
Y
A
M
K
V
L
-
K
K
A
S
L
K
V
-
R
D
--------
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
V----------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
N
E
-----
T
M
N
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
----
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------
412
Blastp_CBE
38.67
40%
-2
- C1 -
-
6G77
2
KS6A6_HUMAN
B:
[30-307]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
-
G
Q
L
----
Y
A
M
K
V
L
-
K
K
A
S
L
K
V
-
R
D
--------
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
VDQ--
E
K
----
K
----
A
Y
---------
S
-
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
N
E
-----
T
M
N
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
----
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------
369
Blastp_CBE
38.56
40%
2
- C1 -
-
5D9K
2
KS6A3_HUMAN
A:
[31-322]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
-------
K
---
I
S
-
G
S
D
ARQL
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
-------------------------------------
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
------
T
F
Y
F
D
------------------------------------------
430
Blastp_CBE
38.47
40%
-35
- C1 -
-
5LIH
3
KPCI_HUMAN
B:
[4-306]
-----------------------------------------------------------------------------
L
----
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
-
D
R
I
----
Y
A
M
K
V
V
K
K
E
L
----------
V
Q
T
E
K
H
V
F
E
Q
--
A
S
---
N
---
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
-
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DI-----------EDY--
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
------------------------------------------
385
Blastp_CBE
38.11
39%
-7
- C1 -
-
3A62
1
KS6B1_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
-
G
K
I
----
F
A
M
K
V
L
K
K
--------------
A
E
R
N
I
L
-
E
--
E
V
---
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------------------------
K
---
E
--------------------------------
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
-----------------------------------------------------
370
Blastp_CBE
37.90
40%
5
- C1 -
-
5D9L
2
KS6A3_HUMAN
A:
[31-322]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
-------
K
---
I
S
-
G
S
D
ARQL
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
------------------------------------------
368
Blastp_CBE
37.66
40%
-1
- C1 -
-
5D9K
2
KS6A3_HUMAN
B:
[31-322]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
-------
K
---
I
S
-
G
S
D
ARQL
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
---------------------------------
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
------------------------------------------
405
Blastp_CBE
36.20
40%
12
- C1 -
-
4EL9
1
KS6A3_MOUSE
A:
[26-305]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
-------
K
---
I
S
-
G
S
D
ARQL
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
-----
R
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
-----
E
K
----
K
----
A
Y
---------
S
-
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------
374
Blastp_CBE
36.02
40%
-5
- C1 -
-
3A61
1
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
-
G
K
I
----
F
A
M
K
V
L
---------------
K
A
E
R
N
I
L
-
E
--
E
V
---
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
--------------------------------------------------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
------------------------------------------------------
409
Blastp_CBE
35.80
40%
-10
- C1 -
-
4RLO
4
KS6B1_HUMAN
B:
[5-287]
----------------------------------------------------------------------------------
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
-
G
K
I
----
F
A
M
K
V
L
K
K
-----------------------------
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
S
I-----------------------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
------------------------------------------------------
376
Blastp_CBE
35.76
40%
-8
- C1 -
-
3A60
1
KS6B1_HUMAN
A:
[19-299]
------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
-
G
K
I
----
F
A
M
K
V
L
K
K
A
M
-----------
K
A
E
R
N
I
L
-
E
--
E
V
---
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------------------------
K
---
E
---------------------------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
------------------------------------------------------
377
Blastp_CBE
35.59
39%
-8
- C1 -
-
2Z7S
1
KS6A1_HUMAN
A:
[29-308]
-----------------------------------------------------------------------------------
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
KVT
R
---
P
---
D
S
-
G
H
L
----
Y
A
M
K
V
L
-
K
------------------
I
L
-
A
--
D
V
---
N
---
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
L
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
-
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
------------------------------------------------------
418
Blastp_CBE
35.24
40%
-5
- C1 -
-
6G78
1
KS6A6_HUMAN
A:
[30-307]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
-
G
Q
L
----
Y
A
M
K
V
L
-
K
K
A
S
L
K
V
-
R
D
--------
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
VDQ--------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
N
E
-----
T
M
N
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
----
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------
375
Blastp_CBE
34.55
40%
-5
- C1 -
-
3A60
1
KS6B1_HUMAN
B:
[19-300]
------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
-
G
K
I
----
F
A
M
K
V
L
K
K
-----------------------------
K
---
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
S
------------------------------
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
-----------------------------------------------------
367
Blastp_CBE
34.34
40%
2
- C1 -
-
3G51
1
KS6A3_MOUSE
A:
[25-304]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
-------
K
---
I
S
-
G
S
D
ARQL
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
----------
R
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
I-----------------------------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------
378
Blastp_CBE
34.23
39%
1
- C1 -
-
2Z7R
1
KS6A1_HUMAN
A:
[29-308]
-----------------------------------------------------------------------------------
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
KVT
R
---
P
---
D
S
-
G
H
L
----
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
------------
I
L
-
A
--
D
V
---
N
---
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
L
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
-
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
------------------------------------------------------
379
Blastp_CBE
33.91
39%
-10
- C1 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[29-308]
-----------------------------------------------------------------------------------
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
KVT
R
---
P
---
D
S
-
G
H
L
----
Y
A
M
K
V
L
--------------------
I
L
-
A
--
D
V
---
N
---
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
L
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
-
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
------------------------------------------------------
404
Blastp_CBE
33.84
40%
9
- C1 -
-
4GUE
1
KS6A3_MOUSE
A:
[26-305]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
-------
K
---
I
S
-
G
S
D
ARQL
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
--------
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
------------
E
K
----
K
----
A
Y
---------
S
-
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------
403
Blastp_CBE
33.19
40%
9
- C1 -
-
3UBD
1
KS6A3_MOUSE
A:
[25-304]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
-------
K
---
I
S
-
G
S
D
ARQL
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
------
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
------------
E
K
----
K
----
A
Y
---------
S
-
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------
433
Blastp_CBE
33.00
40%
-16
- C1 -
-
6G76
1
KS6A6_HUMAN
B:
[30-307]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
-
G
Q
L
----
Y
A
M
K
V
L
-
K
K
A
S
L
K
V
----------
R
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
---
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
VD-----------------------------------
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
N
E
-----
T
----------------
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
----
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------
434
Blastp_CBE
32.81
40%
-4
- C1 -
-
6G76
2
KS6A6_HUMAN
A:
[30-307]
-----------------------------------------------------------------------------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
-
G
Q
L
----
Y
A
M
K
V
L
-
K
K
A
S
L
K
V
-
R
D
--------
D
I
L
-
V
--
E
V
---
N
---
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
VD---
Q
E
----
K
----
K
A
---------
Y
-
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
D
R
--
N
E
-----
T
M
N
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
----
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------