@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KAPCG_HUMAN: (2021-11-22 )
MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
Atome Classification :
(300 SA)
-----------------------------------------------------------------------------------------------------------.........10..---......20......-------------..30.......-.40-----.---------------.......50..-......60.---.---.---....-.70........80-..-......90.....-.-..---100-..-.......110...-....120.......130....-.-.----.140.......150.......160........170....-...180.......-----------------------------190-.--.-----..----.----..---------..200--.........210--..---.-----....220.......230....-...----240----..--..-----...250..------.--..--..-----260-........270.......280...-..-....290.......300---.......310.......320------------.........-330......-----.---.340----.......--..350
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------MGNAPAKKD
T
E
Q
E
---
E
S
V
N
E
F
L
A
K
ARG
D
F
-------------
L
Y
RWGNPAQNT-A
S
S
-----
D
---------------
Q
F
E
R
L
R
T
LGMG-SF
G
R
V
M
L
V
R
---H---Q---ETG
G
-
H
Y
A
M
K
I
L
N
K
Q
K
V
V
-
K
M
-
K
Q
V
E
H
I
L
N
E
K
R
I
L
-
Q
-AI---D---F
P
-
F
L
V
K
L
Q
F
SFKDN
S
-
Y
L
Y
L
V
M
EYVP
G
G
E
M
F
S
R
L
Q
R
V-G-R----FSE
P
H
A
C
F
Y
A
A
Q
V
V
L
A
V
Q
Y
L
H
S
-
L
D
L
I
H
RDLKPE
N
L
L
ID-QQG
Y
L
Q
VTDF
G
F
A
-----------------------------
K
---R--V-----KG----
R
----
T
W
---------
T
L
C----GTPEYL
A
P
E
I
I
L--SK---G-----YNK
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
AVGF-PPF----YAD----
Q
P
--
I
Q
-----
I
Y
E
K
I
VSG------R--VR--F
P
-----
S
K
--
L
S
S
D
L
K
H
L
L
R
S
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-RNGVGDIKNH
K
W
F
A
T
T
S
---
W
I
A
I
Y
E
KKVEAPFIPKYT--------------GPGDASNFD-D-YE
E
E
E
L
R
-----
I
---SI------
N
E
K
C
A
K
E
--
F
SEF
108
Blastp_CBE
96.47
81%
-100
- C1 -
-
1SMH
6
KAPCA_BOVIN
A:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
E
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
107
Blastp_CBE
95.29
81%
-96
- C1 -
-
1XHA
1
KAPCA_BOVIN
A:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
E
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
101
Blastp_CBE
95.11
82%
-101
- C1 -
-
1CMK
1
KAPCA_PIG
E:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
F
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
Y
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
294
Blastp_CBE
95.06
80%
-95
- C1 -
-
4DFZ
1
KAPCA_MOUSE
E:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
C
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
71
Blastp_CBE
95.01
83%
-98
- C1 -
-
3E8C
1
KAPCA_BOVIN
A:
[7-350]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
70
Blastp_CBE
94.87
83%
-96
- C1 -
-
3E8C
1
KAPCA_BOVIN
B:
[4-350]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
76
Blastp_CBE
94.75
83%
-97
- C1 -
-
1Q8U
3
KAPCA_BOVIN
A:
[7-350]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
60
Blastp_CBE
94.67
83%
-96
- C1 -
-
3E8E
1
KAPCA_BOVIN
P:
[7-350]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
74
Blastp_CBE
94.64
83%
-98
- C1 -
-
1SVE
2
KAPCA_BOVIN
A:
[7-350]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
68
Blastp_CBE
94.60
83%
-95
- C1 -
-
3E8C
1
KAPCA_BOVIN
D:
[4-350]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
181
Blastp_CBE
94.57
81%
-95
- C1 -
-
3QAM
1
KAPCA_MOUSE
E:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
A
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
65
Blastp_CBE
94.52
83%
-97
- C1 -
-
3E8E
1
KAPCA_BOVIN
A:
[7-350]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
69
Blastp_CBE
94.38
83%
-97
- C1 -
-
3E8C
1
KAPCA_BOVIN
C:
[7-350]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
25
Blastp_CBE
94.37
82%
-99
- C1 -
-
1CDK
2
KAPCA_PIG
A:
[8-350]
-------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
F
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
Y
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
27
Blastp_CBE
94.30
82%
-102
- C1 -
-
5J5X
1
KAPCA_HUMAN
A:
[10-351]
--------------------------------------------------------------------------------------------------------------------
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
72
Blastp_CBE
94.18
83%
-99
- C1 -
-
1VEB
1
KAPCA_BOVIN
A:
[10-350]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
287
Blastp_CBE
94.15
81%
-95
- C1 -
-
4DG2
1
KAPCA_MOUSE
E:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
3
PsiBlast_PDB
94.08
83%
-107
- C1 -
-
2F7Z
1
KAPCA_BOVIN
E:
[16-351]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
24
Blastp_CBE
94.05
82%
-96
- C1 -
-
1CDK
2
KAPCA_PIG
B:
[8-350]
-------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
F
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
Y
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
295
Blastp_CBE
94.04
80%
-93
- C1 -
-
4DFX
5
KAPCA_MOUSE
E:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
C
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
551
HHSearch
94.01
81%
-98
- C1 -
-
5N3J
4
KAPCA_CRIGR
A:
[14-353]
----------------------------------------------------------------------------------------------------------------------
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
245
Blastp_CBE
93.98
81%
-94
- C1 -
-
5N3D
2
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
--
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
147
Blastp_CBE
93.90
83%
-100
- C1 -
-
1XH7
1
KAPCA_BOVIN
A:
[10-350]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
49
Blastp_CBE
93.79
83%
-94
- C1 -
-
5BX7
4
KAPCA_HUMAN
A:
[6-351]
---------------------------------------------------------------------------------------------------------------
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
156
Blastp_CBE
93.66
82%
-98
- C1 -
-
2GNH
2
KAPCA_BOVIN
A:
[10-350]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
51
Blastp_CBE
93.64
83%
-90
- C1 -
-
4UJB
3
KAPCA_HUMAN
A:
[5-351]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
310
Blastp_CBE
93.60
82%
-104
- C1 -
-
4O21
1
KAPCA_MOUSE
A:
[7-342]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
288
Blastp_CBE
93.54
81%
-100
- C1 -
-
4DG0
2
KAPCA_MOUSE
E:
[10-350]
---------------------------------------------------------------------------------------------------------------------
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
104
Blastp_CBE
93.50
82%
-97
- C1 -
-
3ZO1
7
KAPCA_BOVIN
A:
[10-351]
--------------------------------------------------------------------------------------------------------------------
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
247
Blastp_CBE
93.49
81%
-95
- C1 -
-
5N3B
2
KAPCA_CRIGR
A:
[7-353]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
-
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
50
Blastp_CBE
93.46
83%
-93
- C1 -
-
5BX6
4
KAPCA_HUMAN
A:
[6-351]
---------------------------------------------------------------------------------------------------------------
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
111
Blastp_CBE
93.39
83%
-96
- C1 -
-
3ZO2
4
KAPCA_BOVIN
A:
[8-351]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
293
Blastp_CBE
93.35
80%
-93
- C1 -
-
4X6R
5
KAPCA_MOUSE
A:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
C
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
305
Blastp_CBE
93.11
82%
-101
* C1 *
-
6MM5
1
KAPCA_MOUSE
E:
[3-339]
----------------------------------------------------------------------------------------------------------------------------
A
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
211
Blastp_CBE
93.08
81%
-98
- C1 -
-
6EMD
1
KAPCA_CRIGR
A:
[11-353]
------------------------------------------------------------------------------------------------------------------
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
184
Blastp_CBE
93.07
81%
-97
- C1 -
-
3QAL
1
KAPCA_MOUSE
E:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
A
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
52
Blastp_CBE
93.07
83%
-94
- C1 -
-
3VQH
2
KAPCA_HUMAN
A:
[5-351]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
155
Blastp_CBE
93.04
82%
-96
- C1 -
-
2GNI
1
KAPCA_BOVIN
A:
[10-350]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
164
Blastp_CBE
93.01
81%
-99
- C1 -
-
4DG3
1
KAPCA_MOUSE
E:
[35-371]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
A
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
194
Blastp_CBE
92.97
81%
-101
- C1 -
-
4C35
2
KAPCA_BOVIN
A:
[11-351]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
136
Blastp_CBE
92.97
81%
-98
- C1 -
-
5M0L
3
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
550
HHSearch
92.92
81%
-94
- C1 -
-
5N1G
4
KAPCA_CRIGR
A:
[14-353]
----------------------------------------------------------------------------------------------------------------------
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
202
Blastp_CBE
92.92
81%
-99
- C1 -
-
6I2D
1
KAPCA_CRIGR
A:
[11-353]
------------------------------------------------------------------------------------------------------------------
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
12
PsiBlast_PDB
92.80
82%
-100
- C1 -
-
3ZO4
4
KAPCA_BOVIN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
190
Blastp_CBE
92.78
81%
-111
- C1 -
-
4NTT
1
KAPCA_MOUSE
B:
[10-350]
---------------------------------------------------------------------------------------------------------------------
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
185
Blastp_CBE
92.74
81%
-95
- C1 -
-
1RDQ
3
KAPCA_MOUSE
E:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
-----------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
A
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
306
Blastp_CBE
92.55
83%
-101
- C1 -
-
4WB8
2
KAPCA_HUMAN
A:
[2-337]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
549
HHSearch
92.41
84%
-99
- C1 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[73-405]
--------------------------------------------------------------------------------------------------------------------------------
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
307
Blastp_CBE
92.21
82%
-99
- C1 -
-
2GU8
1
KAPCA_HUMAN
A:
[1-337]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
E
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
291
Blastp_CBE
92.20
81%
-93
- C1 -
-
1L3R
3
KAPCA_MOUSE
E:
[1-350]
------------------------------------------------------------------------------------------------------------
G
N
A
A
------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
187
Blastp_CBE
92.17
81%
-92
- C1 -
-
1JBP
2
KAPCA_MOUSE
E:
[9-350]
------------------------------------------------------------------------------------------------------------
G
N
-------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
E
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
198
Blastp_CBE
92.15
81%
-98
- C1 -
-
3X2V
1
KAPCA_MOUSE
A:
[24-357]
-------------------------------------------------------------------------------------------------------------------------------
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
153
Blastp_CBE
91.75
81%
-91
- C1 -
-
3IDB
1
KAPCA_MOUSE
A:
[8-350]
-------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
261
Blastp_CBE
91.71
81%
-105
- C1 -
-
2QUR
1
KAPCA_MOUSE
A:
[11-350]
----------------------------------------------------------------------------------------------------------------------
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
P
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
A
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
183
Blastp_CBE
91.65
81%
-102
- C1 -
-
1BKX
1
KAPCA_MOUSE
A:
[12-350]
----------------------------------------------------------------------------------------------------------------------
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
159
Blastp_CBE
91.63
81%
-100
- C1 -
-
1REJ
1
KAPCA_MOUSE
A:
[16-350]
------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
552
HHSearch
91.50
84%
-94
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[3-336]
-------------------------------------------------------------------------------------------------------------------------------
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
S
E
F
191
Blastp_CBE
91.31
81%
-112
- C1 -
-
4NTT
1
KAPCA_MOUSE
A:
[10-350]
---------------------------------------------------------------------------------------------------------------------
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
308
Blastp_CBE
90.95
81%
-100
- C1 -
-
3PVB
1
KAPCA_MOUSE
A:
[6-345]
----------------------------------------------------------------------------------------------------------------------
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
149
Blastp_CBE
90.86
81%
-97
- C1 -
-
4DIN
1
KAPCA_MOUSE
A:
[9-350]
--------------------------------------------------------------------------------------------------------------------
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
152
Blastp_CBE
90.54
81%
-90
- C1 -
-
3IDC
1
KAPCA_MOUSE
A:
[8-350]
-------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
182
Blastp_CBE
90.49
81%
-95
- C1 -
-
1BX6
1
KAPCA_MOUSE
A:
[12-350]
----------------------------------------------------------------------------------------------------------------------
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
290
Blastp_CBE
89.96
81%
-97
- C1 -
-
3TNQ
1
KAPCA_MOUSE
B:
[17-350]
-------------------------------------------------------------------------------------------------------------------------------
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
214
Blastp_CBE
88.70
81%
-101
- C1 -
-
6EM6
1
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
209
Blastp_CBE
88.28
81%
-102
- C1 -
-
6ERT
1
KAPCA_CRIGR
A:
[16-353]
-----------------------------------------------------------------------------------------------------------------------
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
228
Blastp_CBE
87.97
81%
-102
- C1 -
-
5NW8
2
KAPCA_CRIGR
A:
[12-351]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
253
Blastp_CBE
87.90
81%
-101
- C1 -
-
5N1O
2
KAPCA_CRIGR
A:
[10-353]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
----
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
-
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
213
Blastp_CBE
87.83
81%
-100
- C1 -
-
6EMA
2
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
195
Blastp_CBE
87.83
81%
-102
- C1 -
-
4C34
3
KAPCA_BOVIN
A:
[11-351]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
226
Blastp_CBE
87.78
81%
-100
- C1 -
-
5O5M
1
KAPCA_CRIGR
A:
[12-353]
-------------------------------------------------------------------------------------------------------------------
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----------------
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
148
Blastp_CBE
87.69
81%
-99
- C1 -
-
4HPT
1
KAPCA_MOUSE
E:
[14-350]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
204
Blastp_CBE
87.67
81%
-98
- C1 -
-
6I2B
2
KAPCA_CRIGR
A:
[7-353]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----------------
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
215
Blastp_CBE
87.47
81%
-98
- C1 -
-
6EM2
2
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
210
Blastp_CBE
87.45
81%
-100
- C1 -
-
6ERS
1
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
197
Blastp_CBE
87.38
81%
-100
- C1 -
-
3X2W
1
KAPCA_MOUSE
A:
[19-357]
-----------------------------------------------------------------------------------------------------------------------
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
239
Blastp_CBE
87.37
81%
-96
- C1 -
-
5N3J
4
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
109
Blastp_CBE
87.37
81%
-100
- C1 -
-
6F14
2
KAPCA_CRIGR
A:
[9-351]
-------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
-----
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
281
Blastp_CBE
87.30
81%
-99
- C1 -
-
4HPU
2
KAPCA_MOUSE
E:
[12-350]
-----------------------------------------------------------------------------------------------------------------------
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
273
Blastp_CBE
87.30
81%
-101
- C1 -
-
4IB0
1
KAPCA_MOUSE
A:
[20-356]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
203
Blastp_CBE
87.30
81%
-100
- C1 -
-
6I2C
1
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
271
Blastp_CBE
87.26
81%
-100
- C1 -
-
4IB3
1
KAPCA_MOUSE
A:
[18-356]
-----------------------------------------------------------------------------------------------------------------------
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
236
Blastp_CBE
87.22
81%
-96
- C1 -
-
5N3M
6
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
223
Blastp_CBE
87.21
81%
-100
- C1 -
-
5OT3
3
KAPCA_CRIGR
A:
[15-353]
----------------------------------------------------------------------------------------------------------------------
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
241
Blastp_CBE
87.09
81%
-96
- C1 -
-
5N3H
4
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
292
Blastp_CBE
87.07
81%
-102
- C1 -
-
5N23
1
KAPCA_HUMAN
A:
[9-352]
------------------------------------------------------------------------------------------------------------------
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
P
---------
W
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
--------------------
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
289
Blastp_CBE
87.06
81%
-97
- C1 -
-
2QCS
5
KAPCA_MOUSE
A:
[13-350]
---------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
238
Blastp_CBE
87.04
81%
-96
- C1 -
-
5N3K
5
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
299
Blastp_CBE
87.03
83%
-97
- C1 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[68-405]
---------------------------------------------------------------------------------------------------------------------------
E
E
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
233
Blastp_CBE
87.00
81%
-97
- C1 -
-
5N3Q
4
KAPCA_CRIGR
A:
[15-353]
----------------------------------------------------------------------------------------------------------------------
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
103
Blastp_CBE
87.00
82%
-95
- C1 -
-
3ZO3
12
KAPCA_BOVIN
A:
[12-351]
----------------------------------------------------------------------------------------------------------------------
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
267
Blastp_CBE
86.98
81%
-101
- C1 -
-
4XW6
1
KAPCA_MOUSE
A:
[20-356]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
242
Blastp_CBE
86.98
81%
-95
- C1 -
-
5N3G
4
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
272
Blastp_CBE
86.96
81%
-100
- C1 -
-
4IB1
1
KAPCA_MOUSE
A:
[19-356]
---------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
259
Blastp_CBE
86.96
81%
-96
- C1 -
-
5N1F
3
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
234
Blastp_CBE
86.92
81%
-99
- C1 -
-
5N3P
4
KAPCA_CRIGR
A:
[15-353]
----------------------------------------------------------------------------------------------------------------------
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
31
Blastp_CBE
86.87
82%
-97
- C1 -
-
4UJA
2
KAPCA_HUMAN
A:
[14-351]
---------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
154
Blastp_CBE
86.83
81%
-101
- C1 -
-
3FJQ
1
KAPCA_MOUSE
E:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
298
Blastp_CBE
86.79
83%
-94
- C1 -
-
4WB7
1
DNJB1_HUMAN (first)
B:
[68-405]
---------------------------------------------------------------------------------------------------------------------------
E
E
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
257
Blastp_CBE
86.77
81%
-97
- C1 -
-
5N1H
3
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
196
Blastp_CBE
86.77
81%
-101
- C1 -
-
3FHI
1
KAPCA_MOUSE
A:
[13-350]
---------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
A
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
278
Blastp_CBE
86.72
81%
-99
- C1 -
-
4IAF
1
KAPCA_MOUSE
A:
[21-356]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
237
Blastp_CBE
86.72
81%
-96
- C1 -
-
5N3L
4
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
189
Blastp_CBE
86.71
81%
-96
- C1 -
-
6EM7
4
KAPCA_CRIGR
A:
[13-353]
---------------------------------------------------------------------------------------------------------------------
S
E
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
34
Blastp_CBE
86.69
82%
-98
- C1 -
-
4UJ1
2
KAPCA_HUMAN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
283
Blastp_CBE
86.68
81%
-100
- C1 -
-
4DH7
1
KAPCA_MOUSE
A:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
275
Blastp_CBE
86.65
81%
-98
- C1 -
-
4IAY
1
KAPCA_MOUSE
A:
[21-356]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
150
Blastp_CBE
86.61
81%
-101
- C1 -
-
3OW3
1
KAPCA_MOUSE
A:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
160
Blastp_CBE
86.60
81%
-99
- C1 -
-
1RE8
2
KAPCA_MOUSE
A:
[12-350]
-----------------------------------------------------------------------------------------------------------------------
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
286
Blastp_CBE
86.58
81%
-101
- C1 -
-
4DH1
1
KAPCA_MOUSE
A:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
235
Blastp_CBE
86.55
81%
-99
- C1 -
-
5N3O
6
KAPCA_CRIGR
A:
[16-353]
-----------------------------------------------------------------------------------------------------------------------
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
33
Blastp_CBE
86.54
82%
-101
- C1 -
-
4UJ2
2
KAPCA_HUMAN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
279
Blastp_CBE
86.50
81%
-99
- C1 -
-
4IAD
1
KAPCA_MOUSE
A:
[20-356]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
258
Blastp_CBE
86.50
81%
-92
- C1 -
-
5N1G
4
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
231
Blastp_CBE
86.50
81%
-95
- C1 -
-
5N3S
5
KAPCA_CRIGR
A:
[14-353]
---------------------------------------------------------------------------------------------------------------------
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
285
Blastp_CBE
86.47
81%
-104
- C1 -
-
4DH3
1
KAPCA_MOUSE
A:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
218
Blastp_CBE
86.41
81%
-99
- C1 -
-
6EGW
1
KAPCA_CRIGR
A:
[16-353]
-----------------------------------------------------------------------------------------------------------------------
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
-
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
-
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
158
Blastp_CBE
86.40
81%
-104
- C1 -
-
1REK
2
KAPCA_MOUSE
A:
[13-350]
---------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
282
Blastp_CBE
86.39
81%
-99
- C1 -
-
4DH8
1
KAPCA_MOUSE
A:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
276
Blastp_CBE
86.33
81%
-99
- C1 -
-
4IAK
1
KAPCA_MOUSE
A:
[20-356]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
274
Blastp_CBE
86.28
81%
-98
- C1 -
-
4IAZ
1
KAPCA_MOUSE
A:
[20-356]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
162
Blastp_CBE
86.28
81%
-101
- C1 -
-
1FMO
1
KAPCA_MOUSE
E:
[13-350]
---------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
199
Blastp_CBE
86.25
81%
-98
- C1 -
-
3X2U
1
KAPCA_MOUSE
A:
[19-357]
-----------------------------------------------------------------------------------------------------------------------
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
137
Blastp_CBE
86.21
81%
-98
- C1 -
-
5M0C
3
KAPCA_CRIGR
A:
[16-353]
-----------------------------------------------------------------------------------------------------------------------
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
264
Blastp_CBE
86.20
81%
-95
- C1 -
-
6E21
1
KAPCA_MOUSE
A:
[21-356]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
268
Blastp_CBE
86.17
81%
-99
- C1 -
-
4XW5
1
KAPCA_MOUSE
A:
[20-356]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
178
Blastp_CBE
86.17
81%
-101
- C1 -
-
4C38
4
KAPCA_BOVIN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
277
Blastp_CBE
86.14
81%
-97
- C1 -
-
4IAI
2
KAPCA_MOUSE
A:
[21-356]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
170
Blastp_CBE
86.13
81%
-98
- C1 -
-
2UW6
1
KAPCA_BOVIN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
284
Blastp_CBE
85.94
81%
-100
- C1 -
-
4DH5
1
KAPCA_MOUSE
A:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
280
Blastp_CBE
85.89
81%
-97
- C1 -
-
4IAC
1
KAPCA_MOUSE
A:
[21-356]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
302
Blastp_CBE
85.84
82%
-113
- C1 -
-
6MM7
6
KAPCA_MOUSE
A:
[5-339]
------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
----------------------
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
166
Blastp_CBE
85.74
81%
-96
- C1 -
-
2VO3
1
KAPCA_BOVIN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
200
Blastp_CBE
85.73
81%
-102
- C1 -
-
6FRX
1
KAPCA_HUMAN
A:
[13-351]
-----------------------------------------------------------------------------------------------------------------------
Q
---
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-------------------
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
179
Blastp_CBE
85.69
81%
-98
- C1 -
-
4C37
2
KAPCA_BOVIN
A:
[14-351]
---------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
173
Blastp_CBE
85.54
81%
-95
- C1 -
-
2UW0
1
KAPCA_BOVIN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
301
Blastp_CBE
85.52
82%
-109
- C1 -
-
6MM7
9
KAPCA_MOUSE
D:
[4-339]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
----------------------------
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
163
Blastp_CBE
85.49
81%
-100
- C1 -
-
1ATP
1
KAPCA_MOUSE
E:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
172
Blastp_CBE
85.48
81%
-94
- C1 -
-
2UW3
1
KAPCA_BOVIN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
193
Blastp_CBE
85.43
81%
-99
- C1 -
-
4C36
1
KAPCA_BOVIN
A:
[14-351]
-----------------------------------------------------------------------------------------------------------------------
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
266
Blastp_CBE
85.38
81%
-97
- C1 -
-
5JR7
1
KAPCA_MOUSE
A:
[13-350]
---------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
165
Blastp_CBE
85.37
81%
-94
- C1 -
-
2VO6
1
KAPCA_BOVIN
A:
[14-351]
---------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
270
Blastp_CBE
85.34
81%
-99
- C1 -
-
4WBB
1
KAPCA_MOUSE
B:
[14-350]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
171
Blastp_CBE
85.34
81%
-97
- C1 -
-
2UW5
1
KAPCA_BOVIN
A:
[16-351]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
174
Blastp_CBE
85.22
81%
-98
- C1 -
-
2UVZ
1
KAPCA_BOVIN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
265
Blastp_CBE
85.13
81%
-95
- C1 -
-
5JR7
1
KAPCA_MOUSE
C:
[13-350]
---------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
269
Blastp_CBE
85.11
81%
-93
- C1 -
-
4XW4
1
KAPCA_MOUSE
A:
[20-356]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
168
Blastp_CBE
85.11
81%
-95
- C1 -
-
2VNW
1
KAPCA_BOVIN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
167
Blastp_CBE
85.11
81%
-95
- C1 -
-
2VNY
1
KAPCA_BOVIN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
169
Blastp_CBE
85.06
81%
-97
- C1 -
-
2UW8
1
KAPCA_BOVIN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
300
Blastp_CBE
85.02
82%
-114
- C1 -
-
6MM8
6
KAPCA_MOUSE
C:
[3-339]
----------------------------------------------------------------------------------------------------------------------------
A
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
---------------------------
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
175
Blastp_CBE
84.56
81%
-97
- C1 -
-
2UVY
1
KAPCA_BOVIN
A:
[16-351]
-----------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
N
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
243
Blastp_CBE
83.21
81%
-103
- C1 -
-
5N3F
4
KAPCA_CRIGR
A:
[10-336]
-----------------------------------------------------------------------------------------------------------------
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
---
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
--
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
--
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
---------------------------------
303
Blastp_CBE
83.16
82%
-110
- C1 -
-
6MM6
1
KAPCA_MOUSE
E:
[7-339]
--------------------------------------------------------------------------------------------------------------------------------
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
T
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-----------------------------
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
571
Fugue
67.52
78%
-10
- C1 -
-
1CDK
2
KAPCA_PIG
A:
[8-350]
-----------------------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
---
K
A
K
E
D
F
L
K
K
W
E
N
P
A
-------------
Q
N
T
A
------
H
---
L
-----
D
---------------
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
-N
H
F
A
M
K
I
L
D
K
Q
K
V
V
-
K
-L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
----N--
F
P
-
F
L
V
K
L
E
Y
S
F
K
D
N
-S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-I
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q-
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
KGRT-------------
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
-KGY-------
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-Y
P
P
F
----
F
A
D
------QP
I
Q
-----
I
Y
E
K
I
V
S
G
KVRFPS---------------
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
D
G
V
N
D
I
K
N
H
K
W
F
A
---TTD
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
SI---------
N
E
K
C
G
K
E
--
F
S
E
F
143
Blastp_CBE
63.60
81%
-5
- C1 -
-
5LCP
5
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
225
Blastp_CBE
62.54
81%
-7
- C1 -
-
5OK3
1
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
255
Blastp_CBE
62.38
81%
-13
- C1 -
-
5N1M
3
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
--
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
254
Blastp_CBE
62.23
81%
-10
- C1 -
-
5N1N
2
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
-
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
249
Blastp_CBE
62.18
81%
-9
- C1 -
-
5N39
5
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
--
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
229
Blastp_CBE
62.14
81%
-8
- C1 -
-
5NTJ
2
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
-----
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
227
Blastp_CBE
61.99
81%
-6
- C1 -
-
5O0E
2
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
201
Blastp_CBE
61.91
81%
-4
- C1 -
-
6I2H
1
?
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
246
Blastp_CBE
61.90
81%
-8
- C1 -
-
5N3C
2
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
-
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
248
Blastp_CBE
61.89
81%
-8
- C1 -
-
5N3A
4
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
222
Blastp_CBE
61.85
81%
-6
- C1 -
-
5OTG
1
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
216
Blastp_CBE
61.80
81%
-4
- C1 -
-
6EH3
1
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
250
Blastp_CBE
61.76
81%
-10
- C1 -
-
5N37
6
KAPCA_CRIGR
A:
[1-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
244
Blastp_CBE
61.73
81%
-11
- C1 -
-
5N3E
3
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
-
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
220
Blastp_CBE
61.42
81%
-7
- C1 -
-
5OUC
2
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
256
Blastp_CBE
61.35
81%
-10
- C1 -
-
5N1L
4
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
--
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
252
Blastp_CBE
61.21
81%
-6
- C1 -
-
5N33
3
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
--
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
146
Blastp_CBE
61.09
82%
-4
- C1 -
-
3AMA
1
KAPCA_HUMAN
A:
[2-351]
------------------------------------------------------------------------------------------------------------
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
-----
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
251
Blastp_CBE
61.08
81%
-8
- C1 -
-
5N36
2
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
--
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
205
Blastp_CBE
60.49
81%
-6
- C1 -
-
6I2A
1
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
212
Blastp_CBE
60.42
81%
-5
- C1 -
-
6EMB
1
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
207
Blastp_CBE
60.15
81%
-5
- C1 -
-
6ERW
2
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
----
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
T
E
F
145
Blastp_CBE
60.14
82%
-3
- C1 -
-
3AMB
1
KAPCA_HUMAN
A:
[4-351]
--------------------------------------------------------------------------------------------------------------
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
D
F
-------------
L
K
K
W
E
S
P
A
Q
N
T
-
A
H
L
-----
D
---------------
Q
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
Q
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
-----
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
K
C
G
K
E
--
F
S
E
F
217
Blastp_CBE
58.70
81%
-0
- C1 -
-
6EH2
2
KAPCA_CRIGR
A:
[3-353]
-----------------------------------------------------------------------------------------------------------
M
G
N
A
A
A
A
K
K
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
----
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
-
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
----------
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
--
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
----
I
------
N
E
--
G
K
E
--
F
T
E
F
565
HHSearch
57.94
40%
-57
- C1 -
-
3TXO
1
KPCL_HUMAN
A:
[23-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
---
V
---
K
---
E
T
G
D
-
L
Y
A
V
K
V
L
K
K
D
V
I
L
-
Q
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
-
S
-
L
A
R--
N
---
H
P
-
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
-
R
-
R
----
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
-----------------------------
K
---
E
--
G
-----
I
-----------------------
C
----
G
T
P
D
Y
I
A
P
E
I
L
Q
--
E
M
---
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
-
A
P
F
----
E
A
E
----
N
E
--
D
D
-----
L
F
E
A
I
L
N
D
------
E
--
V
V
--
Y
P
-----
T
W
--
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
-
S
L
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
--------------
S
R
E
D
V
S
N
F
D
-
P
D
F
I
K
E
E
P
V
-----
L
---
T
P
IDEGHL
P
M
I
N
Q
D
E
--
F
R
N
F
457
Blastp_CBE
57.89
38%
-66
- C1 -
-
5BML
1
ROCK1_HUMAN
A:
[73-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
D-----
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
516
Blastp_CBE
57.80
37%
-85
- C1 -
-
4L6Q
1
ROCK2_HUMAN
A:
[74-379]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
Q
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
----
G
M
---------
V
H
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGF-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
NS
L
C
--
F
P
ED---
A
E
--
I
S
K
H
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
--------------
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
--------------------------------
515
Blastp_CBE
57.75
37%
-82
- C1 -
-
4L6Q
1
ROCK2_HUMAN
B:
[74-379]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
Q
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
----
G
M
---------
V
H
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGF-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
NS
L
C
--
F
P
ED---
A
E
--
I
S
K
H
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
--------------
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
--------------------------------
206
Blastp_CBE
57.68
81%
23
- C1 -
-
6ESA
4
KAPCA_CRIGR
A:
[13-353]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
455
Blastp_CBE
57.54
38%
-79
- C1 -
-
5HVU
1
ROCK1_HUMAN
A:
[73-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
554
HHSearch
57.53
41%
-53
- C1 -
-
2JDO
2
AKT2_HUMAN
A:
[7-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
-----
N
---------------
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
-
N
T
---
R
---
H
P
-
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
--
G
-----
I
S
DGA-
T
----
M
K
---------
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
R
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
--------------
S
E
V
D
T
R
Y
F
D
-
D
E
F
T
A
Q
S
I
T
-----
I
---
T
P
-------------------
452
Blastp_CBE
57.32
38%
-76
- C1 -
-
5KKS
1
ROCK1_HUMAN
B:
[73-378]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
460
Blastp_CBE
57.23
38%
-76
- C1 -
-
4YVC
1
ROCK1_HUMAN
B:
[73-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
534
Blastp_CBE
57.16
37%
-80
- C1 -
-
2F2U
1
ROCK2_BOVIN
A:
[74-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
Q
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
C
A
F
Q
D
D
K
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
----
G
M
---------
V
H
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
NS
L
C
--
F
P
ED---
A
E
--
I
S
K
H
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
D
Q
---
W
N
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
--------------
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
--------------------------------
461
Blastp_CBE
57.08
38%
-78
- C1 -
-
4YVC
1
ROCK1_HUMAN
A:
[73-403]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
------
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
474
Blastp_CBE
56.99
38%
-79
- C1 -
-
2ETK
1
ROCK1_HUMAN
A:
[73-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
473
Blastp_CBE
56.99
38%
-77
- C1 -
-
2ETK
1
ROCK1_HUMAN
B:
[73-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
470
Blastp_CBE
56.82
38%
-78
- C1 -
-
3D9V
1
ROCK1_HUMAN
A:
[73-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
450
Blastp_CBE
56.75
38%
-78
- C1 -
-
5KKT
1
ROCK1_HUMAN
B:
[73-379]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
472
Blastp_CBE
56.71
38%
-78
- C1 -
-
2ETR
1
ROCK1_HUMAN
A:
[73-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
476
Blastp_CBE
56.61
38%
-78
- C1 -
-
2ESM
1
ROCK1_HUMAN
A:
[73-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
471
Blastp_CBE
56.59
38%
-77
- C1 -
-
2ETR
1
ROCK1_HUMAN
B:
[73-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
224
Blastp_CBE
56.59
81%
26
- C1 -
-
5OL3
2
KAPCA_CRIGR
A:
[13-353]
--------------------------------------------------------------------------------------------------------------------
G
E
Q
E
----
S
V
K
E
F
L
A
K
A
K
E
E
F
-------------
L
K
K
W
E
S
P
S
Q
N
T
-
A
Q
L
-----
D
---------------
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
---
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
---
N
---
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
-
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-----------------------------
K
---
R
--
V
-----
K
G
----
R
----
T
W
---------
T
L
C
----
G
T
P
E
Y
L
A
P
E
I
I
L
--
S
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
----
Q
P
--
I
Q
-----
I
Y
E
K
I
V
S
G
------
K
--
V
R
--
F
P
-----
S
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
G
-
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
--------------
G
P
G
D
T
S
N
F
D
-
D
-
Y
E
E
E
E
I
R
-----
V
---
S
I
------
N
E
K
C
G
K
E
--
F
T
E
F
475
Blastp_CBE
56.57
38%
-76
- C1 -
-
2ESM
1
ROCK1_HUMAN
B:
[73-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
453
Blastp_CBE
56.51
38%
-75
- C1 -
-
5KKS
1
ROCK1_HUMAN
A:
[73-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
456
Blastp_CBE
56.41
38%
-73
- C1 -
-
5BML
1
ROCK1_HUMAN
B:
[73-378]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
451
Blastp_CBE
56.35
38%
-80
- C1 -
-
5KKT
1
ROCK1_HUMAN
A:
[73-403]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-----
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
563
HHSearch
56.31
38%
-40
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[3-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
-----
E
---------------
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
N
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
A
W
---
E
---
H
P
-
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
-----
M
L
GDA-
K
----
T
N
---------
E
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
--
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
----
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
------
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
--------------
S
P
F
D
C
S
N
F
D
-
K
E
F
L
N
E
K
P
R
-----
L
---
S
F
ADRALI
N
S
M
D
Q
N
M
--
F
R
N
F
469
Blastp_CBE
56.24
38%
-75
- C1 -
-
3D9V
1
ROCK1_HUMAN
B:
[73-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
458
Blastp_CBE
56.19
38%
-76
- C1 -
-
4YVE
1
ROCK1_HUMAN
B:
[73-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
430
Blastp_CBE
56.16
38%
-81
- C1 -
-
2V55
1
ROCK1_HUMAN
C:
[73-378]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
537
Blastp_CBE
56.04
37%
-112
- C1 -
-
2R7B
2
PDPK1_HUMAN
A:
[33-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
-
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
-
R
L
---
D
---
H
P
-
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
----------------------------
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
--
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
----
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
-
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------
448
Blastp_CBE
55.94
38%
-82
- C1 -
-
5UZJ
1
ROCK1_HUMAN
B:
[73-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
----------
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
528
Blastp_CBE
55.64
37%
-75
- C1 -
-
6ED6
1
ROCK2_HUMAN
A:
[87-396]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
Q
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
----
G
M
---------
V
H
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
----F----
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
NS
L
C
--
F
P
ED---
A
E
--
I
S
K
H
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
--------------
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
--------------------------------
533
Blastp_CBE
55.49
37%
-71
- C1 -
-
2F2U
1
ROCK2_BOVIN
B:
[74-392]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
Q
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
C
A
F
Q
D
D
K
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
----
G
M
---------
V
H
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
NS
L
C
--
F
P
ED---
A
E
--
I
S
K
H
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
D
Q
---
W
N
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
--------------
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
--------------------------------
431
Blastp_CBE
55.48
38%
-81
- C1 -
-
2V55
1
ROCK1_HUMAN
A:
[73-404]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
366
Blastp_CBE
55.45
41%
-50
- C1 -
-
3TXO
1
A:
[23-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
---
V
---
K
---
E
T
G
D
-
L
Y
A
V
K
V
L
K
K
D
V
I
L
-
Q
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
-
S
L
A
R
---
N
---
H
P
-
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
-
R
-
R
----
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
-----------------------------
K
---
E
GI------------------------------
C
----
G
T
P
D
Y
I
A
P
E
I
L
Q
--
E
M
---
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
-
A
P
F
----
E
A
E
----
N
E
--
D
D
-----
L
F
E
A
I
L
N
D
------
E
--
V
V
--
Y
P
-----
T
W
--
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
G
-
S
L
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
--------------
S
R
E
D
V
S
N
F
D
P
D
-
F
I
K
E
E
P
V
-----
L
---
P
I
------
D
E
-----------
532
Blastp_CBE
55.35
37%
-71
- C1 -
-
2H9V
1
ROCK2_BOVIN
A:
[74-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
Q
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
C
A
F
Q
D
D
K
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
----
G
M
---------
V
H
C
DTAV
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
F
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
NS
L
C
--
F
P
ED---
A
E
--
I
S
K
H
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
Q
H
P
F
F
K
N
D
Q
---
W
N
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
--------------
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
--------------------------------
567
HHSearch
55.24
39%
-72
- C1 -
-
4YVC
1
ROCK1_HUMAN
B:
[72-378]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
---
D
----
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
----
E
GMVR
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
--
N
S
LT
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-------
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
-----------------------------------
553
HHSearch
54.82
44%
-48
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[6-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
-----
N
---------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
---
R
---
H
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
--
G
-----
I
K
DGA-
T
----
M
K
---------
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
--------------
S
E
T
D
T
R
Y
F
D
-
E
--------------------------------------
527
Blastp_CBE
54.76
37%
-86
- C1 -
-
6ED6
1
ROCK2_HUMAN
B:
[87-396]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
Q
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
----------------------------------
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
----------
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
NS
L
C
--
F
P
ED---
A
E
--
I
S
K
H
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
--------------
S
D
I
D
S
S
N
F
D
-
D
-
I
E
D
D
K
--------------------------------
558
HHSearch
54.54
37%
-71
- C1 -
-
6ED6
1
ROCK2_HUMAN
A:
[86-411]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
-----
E
---------------
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
A
S
Q
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
---
D
----
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
H
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
D
E
----
T
GMVH
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
----F----
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
D
H
------
K
--
N
S
LC
F
P
ED---
A
E
--
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-------
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
--------------
S
D
I
D
S
S
N
F
D
-
D
-
I
------ETFPI
P
---
K
A
------
F
V
G
N
Q
L
P
--
F
I
G
F
317
Blastp_CBE
54.53
44%
-18
- C1 -
-
6BDL
1
KGP1_HUMAN
A:
[35-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L--
K
---
S
---
E
E
S
K
-
T
F
A
M
K
I
L
K
K
R
H
I
V
-
D
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
-
G
A
---
H
---
S
D
-
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
-
G
-
S
----
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
-----------------------------
K
---
K
--
I
GF---
G
K
----
K
----
T
W
---------
T
F
C
----
G
T
P
E
Y
V
A
P
E
I
I
L
--
N
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
----
S
G
P
----
D
P
--
M
K
-----
T
Y
N
I
I
L
R
G
ID----
M
--
I
E
--
F
P
-----
K
K
--
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
-
N
L
-
K
N
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
--------------
S
P
T
D
T
S
N
F
D
-
S
-
F
P
E
D
---------------------------------
316
Blastp_CBE
54.52
44%
-21
- C1 -
-
6BDL
1
KGP1_HUMAN
B:
[35-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L--
K
---
S
---
E
E
S
K
-
T
F
A
M
K
I
L
K
K
R
H
I
V
-
D
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
-
G
A
---
H
---
S
D
-
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
-
G
-
S
----
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
-----------------------------
K
---
K
--
I
GF---
G
K
----
K
----
T
W
---------
T
F
C
----
G
T
P
E
Y
V
A
P
E
I
I
L
--
N
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
----
S
G
P
----
D
P
--
M
K
-----
T
Y
N
I
I
L
R
G
ID----
M
--
I
E
--
F
P
-----
K
K
--
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
-
N
L
-
K
N
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
--------------
S
P
T
D
T
S
N
F
D
-
S
-
F
P
E
D
---------------------------------
449
Blastp_CBE
54.39
38%
-67
- C1 -
-
5UZJ
1
ROCK1_HUMAN
A:
[73-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
-----
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
-----GY---
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
478
Blastp_CBE
54.31
38%
-72
- C1 -
-
6E9W
1
ROCK1_HUMAN
A:
[101-432]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
-----Y----
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
311
Blastp_CBE
53.89
44%
-15
- C1 -
-
6C0T
3
KGP1_HUMAN
A:
[35-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
L--
K
---
S
---
E
E
S
K
-
T
F
A
M
K
I
L
K
K
R
H
I
V
-
D
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
-
G
A
---
H
---
S
D
-
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
-
G
-
S
----
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
-----------------------------
K
---
K
--
I
GF---
G
K
----
K
----
T
W
---------
T
F
C
----
G
T
P
E
Y
V
A
P
E
I
I
L
--
N
K
---
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
----
S
G
P
----
D
P
--
M
K
-----
T
Y
N
I
I
L
R
G
ID----
M
--
I
E
--
F
P
-----
K
K
--
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
G
-
N
L
-
K
N
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
--------------
S
P
T
D
T
S
N
F
D
-
S
-
F
P
E
D
---------------------------------
540
Blastp_CBE
53.79
37%
-81
- C1 -
-
2BIY
8
PDPK1_HUMAN
A:
[30-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
-
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
-
R
L
---
D
---
H
P
-
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
SPESK
Q
A
----
R
----
A
N
---------
A
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
--
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
----
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
-
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------
544
Blastp_CBE
53.58
36%
-76
- C1 -
-
1UU9
8
PDPK1_HUMAN
A:
[1-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
P
R
K
-
K
R
P
-----
E
---------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
-
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
-
R
L
---
D
---
H
P
-
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S--------------------------
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
--
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
----
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
-
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------
459
Blastp_CBE
53.36
38%
-62
- C1 -
-
4YVE
1
ROCK1_HUMAN
A:
[73-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
I
-
K
R
-
S
D
S
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
-----GY---
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
538
Blastp_CBE
53.32
35%
-43
- C1 -
-
6BXI
1
STK38_HUMAN
B:
[6-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
E
S
L
K
V
I
G
R
G
-
A
F
G
E
V
R
L
V
Q
---
K
---
K
---
D
T
G
H
-
V
Y
A
M
K
I
L
R
K
A
D
M
L
-
E
K
-
E
Q
V
G
H
I
R
A
E
R
D
I
L
-
V
-
E
A
---
D
---
S
L
-
W
V
V
K
M
F
Y
S
F
Q
D
K
L
-
N
L
Y
L
I
M
E
F
L
P
G
G
D
M
M
T
L
L
M
K
K
-
D
-
T
----
L
T
E
E
E
T
Q
F
Y
I
A
E
T
V
L
A
I
D
S
I
H
Q
-
L
G
F
I
H
R
D
I
K
P
D
N
L
L
L
D
-
S
K
G
H
V
K
L
S
D
F
G
L
C
TGLKKAHRTEFYRNLNHSLPSDFTFQNMN
S
---
K
--
R
-----
K
A
----
E
----
T
W
KRNRRQLAF
S
T
V
----
G
T
P
D
Y
I
A
P
E
V
F
M
--
Q
T
---
G
-----
Y
N
K
L
C
D
W
W
S
L
G
V
I
M
Y
E
M
L
I
G
Y
-
P
P
F
----
C
S
E
----
T
P
--
Q
E
-----
T
Y
K
K
V
M
N
W
------
K
ET
L
T
--
F
P
-----
P
E
VP
I
S
E
K
A
K
D
L
I
L
R
F
C
-
C
E
W
E
H
--
R
I
G
-
A
---
P
G
V
E
E
I
K
S
N
S
F
F
E
G
V
D
---
W
E
H
I
R
E
R
P
--
A
A
I
S
I
E
I
K
--------------
S
I
D
D
T
S
N
F
D
-
E
-
F
------------------------------------
545
Blastp_CBE
52.88
37%
-85
- C1 -
-
2PE2
9
PDPK1_HUMAN
A:
[7-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
-
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
-
R
L
---
D
---
H
P
-
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S---------------------------
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
--
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
----
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
-
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------
547
Blastp_CBE
52.75
37%
-85
- C1 -
-
2PE0
4
PDPK1_HUMAN
A:
[7-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
-
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
-
R
L
---
D
---
H
P
-
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S---------------------------
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
--
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
----
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
-
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------
512
Blastp_CBE
52.68
38%
-48
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[5-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
N
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
A
W
---
E
---
H
P
-
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
MLG--
D
A
----
K
----
T
N
---------
E
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
--
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
----
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
--
V
-
R
---
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
--------------
S
P
F
D
C
S
N
F
D
----------------------------------------
511
Blastp_CBE
52.50
38%
-47
- C1 -
-
4RA5
1
B:
[5-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
N
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
A
W
---
E
---
H
P
-
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
MLG--
D
A
----
K
----
T
N
---------
E
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
--
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
----
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
--
V
-
R
---
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
--------------
S
P
F
D
C
S
N
F
D
----------------------------------------
536
Blastp_CBE
52.49
37%
-83
- C1 -
-
3ION
1
PDPK1_HUMAN
A:
[33-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
-
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
-
R
L
---
D
---
H
P
-
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S----------------------------
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
--
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
----
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
-
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------
546
Blastp_CBE
52.48
37%
-83
- C1 -
-
2PE1
5
PDPK1_HUMAN
A:
[7-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
-
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
-
R
L
---
D
---
H
P
-
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
S---------------------------
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
--
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
----
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
-
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------
539
Blastp_CBE
52.37
35%
-42
- C1 -
-
6BXI
1
STK38_HUMAN
A:
[6-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
E
S
L
K
V
I
G
R
G
-
A
F
G
E
V
R
L
V
Q
---
K
---
K
---
D
T
G
H
-
V
Y
A
M
K
I
L
R
K
A
D
M
L
-
E
K
-
E
Q
V
G
H
I
R
A
E
R
D
I
L
-
V
-
E
A
---
D
---
S
L
-
W
V
V
K
M
F
Y
S
F
Q
D
K
L
-
N
L
Y
L
I
M
E
F
L
P
G
G
D
M
M
T
L
L
M
K
K
-
D
-
T
----
L
T
E
E
E
T
Q
F
Y
I
A
E
T
V
L
A
I
D
S
I
H
Q
-
L
G
F
I
H
R
D
I
K
P
D
N
L
L
L
D
-
S
K
G
H
V
K
L
S
D
F
G
L
C
TGLKKAHRTEFYRNLNHSLPSDFTFQNMN
S
---
K
--
R
-----
K
A
----
E
----
T
W
KRNRRQLAF
S
T
V
----
G
T
P
D
Y
I
A
P
E
V
F
M
--
Q
T
---
G
-----
Y
N
K
L
C
D
W
W
S
L
G
V
I
M
Y
E
M
L
I
G
Y
-
P
P
F
----
C
S
E
----
T
P
--
Q
E
-----
T
Y
K
K
V
M
N
W
------
K
ET
L
T
--
F
P
-----
P
E
VP
I
S
E
K
A
K
D
L
I
L
R
F
C
-
C
E
W
E
H
--
R
I
G
-
A
---
P
G
V
E
E
I
K
S
N
S
F
F
E
G
V
D
---
W
E
H
I
R
E
R
P
--
A
A
I
S
I
E
I
K
--------------
S
I
D
D
T
S
N
F
D
-
E
-
F
------------------------------------
541
Blastp_CBE
52.35
37%
-85
- C1 -
-
3NAX
1
PDPK1_HUMAN
A:
[29-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
-
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
-
R
L
---
D
---
H
P
-
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
SPESK
Q
A
----
R
------------------------
A
Q
Y
V
S
P
E
L
L
T
--
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
----
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
-
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------
518
Blastp_CBE
52.11
38%
-43
- C1 -
-
5F9E
1
KPCT_HUMAN
A:
[19-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
N
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
A
W
---
E
---
H
P
-
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
MLG--
D
A
----
K
----
T
N
---------
E
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
--
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
----
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
--
V
-
R
---
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
--------------
S
P
F
D
C
S
N
F
D
----------------------------------------
514
Blastp_CBE
51.93
38%
-46
- C1 -
-
4Q9Z
1
KPCT_HUMAN
A:
[5-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
N
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
A
W
---
E
---
H
P
-
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
MLG--
D
A
----
K
----
T
N
---------
E
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
--
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
----
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
--
V
-
R
---
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
--------------
S
P
F
D
C
S
N
F
D
----------------------------------------
493
Blastp_CBE
51.43
38%
-47
- C1 -
-
4DC2
1
KPCI_MOUSE
A:
[49-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
-----
Q
---------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
D
R
-
I
Y
A
M
R
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
---
N
---
H
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
EGL
R
--
P
-----
G
D
----
T
----
T
S
---------
T
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
--
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DIVG
S
------------NTEDY
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
--------------
G
E
F
G
L
D
N
F
D
----------------------------------------
517
Blastp_CBE
51.30
38%
-44
- C1 -
-
5F9E
1
B:
[19-338]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
N
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
A
W
---
E
---
H
P
-
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
MLG--
D
A
----
K
----
T
N
---------
E
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
--
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
----
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
--
V
-
R
---
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
--------------
S
P
F
D
C
S
N
F
D
----------------------------------------
477
Blastp_CBE
51.18
38%
-52
- C1 -
-
6E9W
1
ROCK1_HUMAN
B:
[101-409]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
---------------
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
---
K
---
S
T
R
K
-
V
Y
A
M
K
L
L
S
K
F
E
M
--------
A
F
F
W
E
E
R
D
I
M
-
A
-
F
A
---
N
---
S
P
-
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
------
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
-----------------------------
M
---
K
--
M
-----
N
K
EGMV
R
----
C
D
---------
T
A
V
----
G
T
P
D
Y
I
S
P
E
V
L
K
--
S
Q
----GY---
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
----
Y
A
D
----
S
L
--
V
G
-----
T
Y
S
K
I
M
N
H
------
K
NS
L
T
--
F
P
DD---
N
D
--
I
S
K
E
A
K
N
L
I
C
A
F
L
-
T
D
R
E
V
--
R
L
G
----
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
--------------
S
D
I
D
T
S
N
F
D
-
D
-
L
E
E
D
K
--------------------------------
355
Blastp_CBE
50.34
42%
-53
- C1 -
-
3D0E
1
AKT2_HUMAN
A:
[2-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
-----
N
---------------
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
-
N
T
---
R
---
H
P
-
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
S
-----
D
G
----
A
----
T
M
---------
K
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
R
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
--------------
S
E
V
D
T
R
Y
F
D
-
D
--------------------------------------
354
Blastp_CBE
50.08
42%
-53
- C1 -
-
3D0E
1
AKT2_HUMAN
B:
[2-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
-----
N
---------------
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
-
N
T
---
R
---
H
P
-
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
S
-----
D
G
----
A
----
T
M
---------
K
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
R
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
--------------
S
E
V
D
T
R
Y
F
D
-
D
--------------------------------------
331
Blastp_CBE
50.05
44%
-49
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[5-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
-----
N
---------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
---
R
---
H
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----
D
G
----
A
----
T
M
---------
K
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
--------------
S
E
T
D
T
R
Y
F
D
-
E
--------------------------------------
324
Blastp_CBE
49.64
44%
-48
- C1 -
-
3QKM
1
AKT1_HUMAN
A:
[5-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
V
T
M
-----
N
---------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
---
R
---
H
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----
D
G
----
A
----
T
M
---------
K
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
--------------
S
E
T
D
T
R
Y
F
D
-
E
--------------------------------------
321
Blastp_CBE
49.61
44%
-42
- C1 -
-
4EKL
1
AKT1_HUMAN
A:
[5-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
V
T
M
-----
N
---------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
---
R
---
H
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----
D
G
----
A
----
T
M
---------
K
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
--------------
S
E
T
D
T
R
Y
F
D
-
E
--------------------------------------
564
HHSearch
49.54
44%
-58
- C1 -
-
4EJN
3
AKT1_HUMAN
A:
[146-438]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
-----
N
---------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
---------------
V
L
-
Q
-
N
S
---
R
---
H
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
--
G
-----
I
K
----------
K
---------
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
--------------
S
E
T
D
T
R
Y
F
-----------------------------------------
352
Blastp_CBE
49.39
42%
-55
- C1 -
-
3E87
1
AKT2_HUMAN
B:
[2-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
-----
N
---------------
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
-
N
T
---
R
---
H
P
-
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
S
-----
D
G
----
A
----
T
M
---------
K
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
R
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
--------------
S
E
V
D
T
R
Y
F
D
-
D
--------------------------------------
353
Blastp_CBE
49.31
42%
-56
- C1 -
-
3E87
1
AKT2_HUMAN
A:
[2-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
-----
N
---------------
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
-
N
T
---
R
---
H
P
-
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
S
-----
D
G
----
A
----
T
M
---------
K
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
R
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
--------------
S
E
V
D
T
R
Y
F
D
-
D
--------------------------------------
326
Blastp_CBE
49.21
44%
-45
- C1 -
-
3QKK
1
AKT1_HUMAN
A:
[5-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
V
T
M
-----
N
---------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
---
R
---
H
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----
D
G
----
A
----
T
M
---------
K
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
--------------
S
E
T
D
T
R
Y
F
D
-
E
--------------------------------------
570
Fugue
48.94
31%
24
- C1 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-533]
RDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARAG
G
L
F
Q
P
L
L
R
A
V
L
A
H
LGQ
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
-------------
F
L
Q
W
K
W
L
E
A
Q
P
-
M
G
E
-----
D
---------------
W
F
L
D
F
R
V
L
G
R
G
-
G
F
G
E
V
F
A
C
Q
---
M
---
K
---
A
T
G
K
-
L
Y
A
C
K
K
L
N
K
K
R
L
K
-
K
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
L
-
A
-
K
V
---
H
---
S
R
-
F
I
V
S
L
A
Y
A
F
E
T
K
T
-
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
-
D
-
E
DNPG
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
D
G
N
V
R
I
S
D
L
G
L
A
-----------------------------
V
---
E
--
L
KAG--
Q
T
----
K
----
T
K
---------
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
--
G
E
---
E
-----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
-
G
P
F
----
R
A
R
GEKV
E
N
--
K
E
-----
L
K
Q
R
V
L
E
Q
------
A
--
V
T
--
Y
P
-----
D
K
--
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
--
R
L
G
-
F
R
-
D
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
TVYAKNGAFSGVAF
E
K
A
D
T
E
F
F
Q
-
E
-
F
A
S
G
T
C
P
-----
I
---
P
W
------
Q
E
E
M
I
E
T
GV
F
G
D
L
320
Blastp_CBE
48.37
42%
-21
- C1 -
-
2R5T
1
SGK1_HUMAN
A:
[29-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
S
N
P
H
A
K
P
-----
S
---------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
---
K
---
A
E
E
V
-
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
-
N
V
---
K
---
H
P
-
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
-
C
----
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
N
IEH--
N
S
----
T
----
T
S
---------
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
--
K
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
----
Y
S
R
----
N
T
--
A
E
-----
M
Y
D
N
I
L
N
K
------
P
--
L
Q
--
L
K
-----
P
N
--
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
--
A
-
K
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
--------------
G
------------------------------------------------
382
Blastp_CBE
48.05
41%
-56
- C1 -
-
4RA4
1
KPCA_HUMAN
A:
[22-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
A
D
---
R
---
K
---
G
T
E
E
-
L
Y
A
I
K
I
L
K
K
D
V
V
I
-
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
A
-
L
L
---
D
---
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
-
K
----
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
HM
M
-----
D
G
----
V
----
T
T
---------
R
F
C
----
G
T
P
D
Y
I
A
P
E
I
I
A
--
Y
Q
---
P
-----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
-
P
P
F
----
D
G
E
----
D
E
--
D
E
-----
L
F
Q
S
I
M
E
H
------
N
--
V
S
--
Y
P
-----
K
S
--
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
--
R
L
G
-
C
G
-
P
E
G
E
R
D
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
V
S
--------------
G
K
G
-
A
E
N
F
D
-
K
-
F
------------------------------------
491
Blastp_CBE
47.97
39%
-51
- C1 -
-
3A8W
1
KPCI_HUMAN
B:
[11-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
D
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
-
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
---
N
---
H
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
G--------
G
----
D
----
T
T
---------
S
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
--
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DI---------------EDY--
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
--------------
G
E
F
G
L
D
N
F
D
----------------------------------------
319
Blastp_CBE
47.88
42%
-25
- C1 -
-
3HDM
1
SGK1_HUMAN
A:
[29-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
S
N
P
H
A
K
P
-----
S
---------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
---
K
---
A
E
E
V
-
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
-
N
V
---
K
---
H
P
-
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
-
C
----
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
N
IEH--
N
S
----
T
----
T
S
---------
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
--
K
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
----
Y
S
R
----
N
T
--
A
E
-----
M
Y
D
N
I
L
N
K
------
P
--
L
Q
--
L
K
-----
P
N
--
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
--
A
-
K
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
--------------
G
------------------------------------------------
542
Blastp_CBE
47.53
36%
-71
- C1 -
-
1UVR
8
PDPK1_HUMAN
A:
[2-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
P
R
K
-
K
R
P
-----
E
---------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
-
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
-
R
L
---
D
---
H
P
-
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
SP---------
A
----
R
A
---------
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
--
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
----
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
-
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------
494
Blastp_CBE
47.41
39%
-48
- C1 -
-
5LI9
13
KPCI_HUMAN
A:
[8-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
D
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
-
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
---
N
---
H
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
--
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D----------------EDY--
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
--------------
G
E
F
G
L
D
N
F
D
----------------------------------------
483
Blastp_CBE
47.24
39%
-49
- C1 -
-
3ZH8
5
KPCI_HUMAN
B:
[7-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
D
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
-
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
---
N
---
H
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
--
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DIVG-------------TEDY-
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
--------------
G
E
F
G
L
D
N
F
D
----------------------------------------
543
Blastp_CBE
47.22
36%
-67
- C1 -
-
1H1W
9
PDPK1_HUMAN
A:
[2-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
P
R
K
-
K
R
P
-----
E
---------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
---
L
---
A
T
S
R
-
E
Y
A
I
K
I
L
E
K
R
H
I
I
-
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
M
-
S
-
R
L
---
D
---
H
P
-
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
-
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
-----------------------------
K
---
V
--
L
SP---------
A
----
R
A
---------
N
F
V
----
G
T
A
Q
Y
V
S
P
E
L
L
T
--
E
K
---
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
----
R
A
G
----
N
E
--
Y
L
-----
I
F
Q
K
I
I
K
L
------
E
--
Y
D
--
F
P
-----
E
K
--
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
G
C
E
E
-
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
--------------------------------------------------------------------------
479
Blastp_CBE
46.79
41%
-50
- C1 -
-
3PFQ
1
KPCB_RAT
A:
[343-633]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
S
E
---
R
---
K
---
G
T
D
E
-
L
Y
A
V
K
I
L
K
K
D
V
V
I
-
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
A
L
P
G
---
K
---
P
P
-
F
L
T
Q
L
H
S
C
F
Q
T
M
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
-
R
----
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
--
N
IW---
D
G
----
V
----
T
T
---------
K
F
C
----
G
T
P
D
Y
I
A
P
E
I
I
A
--
Y
Q
---
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
-
A
P
F
----
E
G
E
----
D
E
--
D
E
-----
L
F
Q
S
I
M
E
H
------
N
--
V
A
--
Y
P
-----
K
S
--
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
--
R
L
G
-
C
G
-
P
E
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
S
--------------
G
-
R
N
A
E
N
F
D
-
R
-
F
------------------------------------
492
Blastp_CBE
46.58
39%
-49
- C1 -
-
3A8W
1
KPCI_HUMAN
A:
[11-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
D
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
---
N
---
H
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
--
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DI---------------EDY--
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
--------------
G
E
F
G
L
D
N
F
D
----------------------------------------
481
Blastp_CBE
46.21
39%
-48
- C1 -
-
5LIH
3
KPCI_HUMAN
A:
[7-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
D
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
---------
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
---
N
---
H
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
--
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DIV--------------NTEDY
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
--------------
G
E
F
G
L
D
N
F
D
----------------------------------------
318
Blastp_CBE
46.05
42%
-19
- C1 -
-
3HDN
1
SGK1_HUMAN
A:
[29-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
S
N
P
H
A
K
P
-----
S
---------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
---
K
---
A
E
E
V
-
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
-
N
V
---
K
---
H
P
-
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
-
C
----
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
N
IEH--
N
S
----
T
----
T
S
---------
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
--
K
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
----
Y
S
R
----
N
T
--
A
E
-----
M
Y
D
N
I
L
N
K
------
P
--
L
Q
--
L
K
-----
P
N
--
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
G
--
A
-
K
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
------------------------------------------------------------------
501
Blastp_CBE
46.01
41%
-20
- C1 -
-
4OTG
1
A:
[12-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
---
R
---
P
S
G
E
-
L
F
A
I
K
A
L
K
K
G
D
I
V
-
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
-
A
V
---
T
SAG
H
P
-
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
----
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
-----------------------------
K
---
E
--
G
-----
M
G
YGD-
R
----
T
----------
S
F
C
----
G
T
P
E
F
L
A
P
E
V
L
T
--
D
T
---
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
----
P
G
D
----
D
E
--
E
E
-----
V
F
D
S
I
V
N
D
------
E
--
V
R
--
Y
P
-----
R
F
--
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
-
S
S
-
E
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
--------------
G
R
T
D
V
S
N
F
D
-
E
--------------------------------------
560
HHSearch
46.00
42%
-26
- C1 -
-
4OTH
1
A:
[9-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
-----
E
---------------
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
---
R
---
P
S
G
E
-
L
F
A
I
K
A
L
K
K
G
D
I
V
-
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
-
A
V
TSA
G
---
H
P
-
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
----
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
-----------------------------
K
-------------------------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
----
P
G
D
----
D
E
--
E
E
-----
V
F
D
S
I
V
N
D
------
E
--
V
R
--
Y
P
-----
R
F
--
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
-
S
S
-
E
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
--------------
G
R
T
D
V
S
N
F
D
-
E
--------------------------------------
405
Blastp_CBE
45.90
37%
-1
- C1 -
-
4NW6
1
KS6A3_HUMAN
A:
[23-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
-
A
D
P
-----
S
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
ISG
S
---
D
A
R
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
IDH--
E
K
----
K
----
A
Y
---------
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------
T
F
Y
F
D
----------------------------------------
411
Blastp_CBE
45.71
39%
4
- C1 -
-
1VZO
1
KS6A5_HUMAN
A:
[54-352]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
N
F
E
L
L
K
V
L
G
T
G
-
A
Y
G
K
V
F
L
V
R
---
K
ISG
H
---
D
T
G
K
-
L
Y
A
M
K
V
L
K
K
A
T
I
V
Q
K
A
-
K
T
T
E
H
T
R
T
E
R
Q
V
L
-
E
-
H
I
R--
Q
---
S
P
-
F
L
V
T
L
H
Y
A
F
Q
T
E
T
-
K
L
H
L
I
L
D
Y
I
N
G
G
E
L
F
T
H
L
S
Q
R
-
E
-
R
----
F
T
E
H
E
V
Q
I
Y
V
G
E
I
V
L
A
L
E
H
L
H
K
-
L
G
I
I
Y
R
D
I
K
L
E
N
I
L
L
D
-
S
N
G
H
V
V
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
F
-----
V
A
DETE
R
----
A
Y
---------
D
F
C
----
G
T
I
E
Y
M
A
P
D
I
V
R
GG
D
-----------
D
K
A
V
D
W
W
S
L
G
V
L
M
Y
E
L
L
T
G
A
-
S
P
F
----
T
V
D
GEKN
S
Q
--
A
E
-----
I
S
R
R
I
L
K
S
------
E
--
P
P
--
Y
P
-----
Q
E
--
M
S
A
L
A
K
D
L
I
Q
R
L
L
M
K
D
P
K
K
--
R
L
G
-
C
G
-
P
R
D
A
D
E
I
K
E
H
L
F
F
Q
K
I
N
---
W
D
D
L
A
A
K
K
V
P
A
P
F
K
P
V
I
R
--------------
D
E
L
D
V
--------------------------------------------
407
Blastp_CBE
45.67
37%
-0
- C1 -
-
4NUS
1
KS6A3_HUMAN
A:
[23-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
-
A
D
P
-----
S
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
ISG
S
---
D
A
R
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
IDH--
E
K
----
K
----
A
Y
---------
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
--------------------
T
F
Y
F
D
----------------------------------------
574
Fugue
45.06
33%
5
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
---------------------------------------------------------------------------------------------SGEVRLRQLEQFIL
D
G
P
A
Q
T
N
G
Q
C
F
S
V
---
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
NNSPLRREKNILE
Y
L
E
W
A
K
P
F
T
S
K
-
V
K
Q
MRLHR
E
---------------
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
L
---
K
---
N
A
D
K
-
V
F
A
M
K
I
L
N
K
W
E
M
L
-
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
-
N
G
---
D
---
S
K
-
W
I
T
T
L
H
Y
A
F
Q
D
D
N
-
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
-
E
D
R
----
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
H
I
R
L
A
D
F
G
S
C
-----------------------------
L
---
K
--
L
-----
M
E
DGTV
Q
----
S
S
---------
V
A
V
----
G
T
P
D
Y
I
S
P
E
I
L
Q
--
A
M
---
E
GGKGR
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
----
Y
A
E
----
S
L
--
V
E
-----
T
Y
G
K
I
M
N
H
------
K
--
E
R
--
F
Q
FPTQV
T
D
--
V
S
E
N
A
K
D
L
I
R
R
L
I
-
C
S
R
E
H
--
R
L
G
----
Q
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
R
N
--
C
E
A
P
Y
I
P
E
V
S
--------------
S
P
T
D
T
S
N
F
D
-
V
-
D
S
G
H
H
L
P
-----
F
VGF
T
Y
------
T
S
S
C
V
L
S
--
D
R
S
C
406
Blastp_CBE
44.98
37%
2
- C1 -
-
4NW5
1
KS6A3_HUMAN
A:
[23-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
-
A
D
P
-----
S
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
ISG
S
---
D
A
R
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
IDH--
E
K
----
K
----
A
Y
---------
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------
T
F
Y
F
D
----------------------------------------
356
Blastp_CBE
44.86
41%
4
- C1 -
-
6S9X
1
?
A:
[81-440]
-----------------------------------------------------------------------------------------------------------------------------------
Q
A
A
A
E
M
-------------
D
F
R
S
G
S
P
S
D
N
S
-
G
A
E
-----
E
MEVSLAKPKHRVTMN
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
-------------------
Q
-
N
S
---
R
---
H
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
-
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
----------------------------
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
----
D
H
--
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
--------------
S
E
T
D
T
R
Y
F
D
-
E
--------------------------------------
480
Blastp_CBE
44.64
39%
-43
- C1 -
-
5LIH
3
KPCI_HUMAN
B:
[7-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
---
K
T
D
R
-
I
Y
A
M
K
V
V
K
K
E
L
-----------
V
Q
T
E
K
H
V
F
E
Q
-
A
S
---
N
---
H
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
--
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DI---------------EDY--
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
--------------
G
E
F
G
L
D
N
F
D
----------------------------------------
500
Blastp_CBE
44.57
41%
-23
- C1 -
-
4OTH
1
A:
[12-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
---
R
---
P
S
G
E
-
L
F
A
I
K
A
L
K
K
G
D
I
V
-
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
-
A
V
---
T
SAG
H
P
-
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
----
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
-----------------------------
K
-------------------------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
----
P
G
D
----
D
E
--
E
E
-----
V
F
D
S
I
V
N
D
------
E
--
V
R
--
Y
P
-----
R
F
--
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
-
S
S
-
E
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
--------------
G
R
T
D
V
S
N
F
D
-
E
--------------------------------------
499
Blastp_CBE
44.47
41%
-26
- C1 -
-
4OTI
1
A:
[12-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
---
R
---
P
S
G
E
-
L
F
A
I
K
A
L
K
K
G
D
I
V
-
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
L
-
A
-
A
V
---
T
SAG
H
P
-
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
-
V
----
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
--------------------------------------------------------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
----
P
G
D
----
D
E
--
E
E
-----
V
F
D
S
I
V
N
D
------
E
--
V
R
--
Y
P
-----
R
F
--
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
-
S
S
-
E
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
--------------
G
R
T
D
V
S
N
F
D
-
E
--------------------------------------
487
Blastp_CBE
44.20
39%
-49
- C1 -
-
6ILZ
1
KPCI_HUMAN
C:
[11-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---------
D
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
-
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
---
N
---
H
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
--
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DI---------------DY---
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
--------------
G
E
F
G
L
D
N
F
D
----------------------------------------
395
Blastp_CBE
44.18
37%
-7
- C1 -
-
5D9K
2
KS6A3_HUMAN
A:
[26-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
A
D
P
-----
S
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
ISG
S
---
D
A
R
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
------------------------------------
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
--------------------
T
F
Y
F
D
----------------------------------------
486
Blastp_CBE
43.80
39%
-52
- C1 -
-
6ILZ
1
KPCI_HUMAN
E:
[12-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---------
D
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
-
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
---
N
---
H
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
--
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DI---------------DY---
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
--------------
G
E
F
G
L
D
N
F
D
----------------------------------------
488
Blastp_CBE
43.45
39%
-43
- C1 -
-
6ILZ
1
KPCI_HUMAN
A:
[11-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---------
D
R
-
I
Y
A
M
K
V
V
K
K
E
L
V
N
-
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
---
N
---
H
P
-
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
-
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
-----------------------------
K
---
E
GL
R
-----
P
G
----
D
----
T
T
---------
S
F
C
----
G
T
P
N
Y
I
A
P
E
I
L
R
--
G
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DIV--------------DY---
L
F
Q
V
I
L
E
K
------
Q
--
I
R
--
I
P
-----
R
S
--
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
--------------
G
E
F
G
L
D
N
F
D
----------------------------------------
394
Blastp_CBE
42.89
37%
-2
- C1 -
-
5D9K
2
KS6A3_HUMAN
B:
[26-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
A
D
P
-----
S
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
ISG
S
---
D
A
R
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--------------------------------
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
---------------------
T
F
Y
F
D
----------------------------------------
535
Blastp_CBE
42.62
37%
-49
- C1 -
-
1XJD
1
A:
[23-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
---
K
T
N
Q
-
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
A
W
---
E
---
H
P
-
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
-
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-----------------------------
K
---
E
NM
L
-----
G
D
----
A
----
K
T
---------
N
F
C
----
G
T
P
D
Y
I
A
P
E
I
L
L
--
G
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
----
D
E
--
E
E
-----
L
F
H
S
I
R
M
D
------
N
--
P
F
--
Y
P
-----
R
W
--
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
G
--
V
-
R
---
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
--------------------------
N
F
D
K
E
-
F
L
---------------
F
------
A
------------
404
Blastp_CBE
42.36
37%
7
- C1 -
-
5D9L
2
KS6A3_HUMAN
A:
[23-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
-
A
D
P
-----
S
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
ISG
S
---
D
A
R
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
-------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
--------------
R
P
E
D
T
F
Y
F
D
----------------------------------------
502
Blastp_CBE
42.14
41%
-22
- C1 -
-
4CRS
1
A:
[14-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
C
C
A
V
L
L
R
G
-
H
F
G
K
V
L
L
A
E
---
Y
---
K
---
N
T
N
E
-
M
F
A
I
K
A
L
K
K
G
D
I
V
-
A
R
-
D
E
V
D
S
L
M
C
E
K
R
I
F
-
E
-
T
V
---
N
SVR
H
P
-
F
L
V
N
L
F
A
C
F
Q
T
K
E
-
H
V
C
F
V
M
E
Y
A
A
G
G
D
L
M
M
H
I
H
---
T
-
D
----
V
F
E
P
R
A
V
F
Y
A
A
C
V
V
L
G
L
Q
Y
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
F
V
K
I
A
D
F
G
L
C
-----------------------------
K
---
E
--
G
-----
M
G
YGD-
R
----
T
----------
S
F
C
----
G
T
P
E
F
L
A
P
E
V
L
T
--
E
T
---
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
I
Y
E
M
L
V
G
E
-
S
P
F
----
P
G
D
----
D
E
--
E
E
-----
V
F
D
S
I
V
N
D
------
E
--
V
R
--
Y
P
-----
R
F
--
L
S
T
E
A
I
S
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
G
-
A
S
-
E
K
D
A
E
D
V
K
K
H
P
F
F
R
L
I
D
---
W
S
A
L
M
D
K
K
V
K
P
P
F
I
P
T
I
R
--------------
G
R
E
D
V
S
N
F
D
-
D
--------------------------------------
370
Blastp_CBE
41.83
40%
-11
- C1 -
-
3A62
1
KS6B1_HUMAN
A:
[19-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
G
K
-
I
F
A
M
K
V
L
K
K
---------------
A
E
R
N
I
L
-
E
-
E
V
---
K
---
H
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------------------------
K
---
E
-------------------------------
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
----
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
-----------------------------------------------------------------
497
Blastp_CBE
41.69
38%
-22
- C1 -
-
6G78
1
KS6A6_HUMAN
B:
[26-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
-----
A
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
--
K
V
-
R
D
--------
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
V---------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
N
E
-----
T
M
N
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
---
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------------------
496
Blastp_CBE
41.19
38%
-5
- C1 -
-
6G77
2
KS6A6_HUMAN
A:
[26-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
-----
A
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
--
K
V
-
R
D
--------
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
VDQ--
E
K
----
K
----
A
Y
---------
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
N
E
-----
T
M
N
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
---
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------------------
409
Blastp_CBE
40.88
37%
-12
- C1 -
-
4GUE
1
KS6A3_MOUSE
A:
[18-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
-
A
D
P
-----
S
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
ISG
S
---
D
A
R
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
-
R
D
R
V
--------
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
------------
E
K
----
K
----
A
Y
---------
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------------------
495
Blastp_CBE
40.72
38%
-3
- C1 -
-
6G77
2
KS6A6_HUMAN
B:
[26-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
-----
A
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
--
K
V
-
R
D
--------
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
VDQ--
E
K
----
K
----
A
Y
---------
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
N
E
-----
T
M
N
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
---
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------------------
412
Blastp_CBE
40.70
37%
-14
- C1 -
-
3UBD
1
KS6A3_MOUSE
A:
[17-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
-
A
D
P
-----
S
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
ISG
S
---
D
A
R
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
-
R
D
R
V
------
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
------------
E
K
----
K
----
A
Y
---------
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------------------
403
Blastp_CBE
40.57
37%
-14
- C1 -
-
3G51
1
KS6A3_MOUSE
A:
[17-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
-
A
D
P
-----
S
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
ISG
S
---
D
A
R
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
----------
R
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
I----------------------------------
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------------------
369
Blastp_CBE
39.93
40%
-13
- C1 -
-
3A60
1
KS6B1_HUMAN
A:
[19-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
G
K
-
I
F
A
M
K
V
L
K
K
A
M
------------
K
A
E
R
N
I
L
-
E
-
E
V
---
K
---
H
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------------------------
K
---
E
--------------------------------------
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
----
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
------------------------------------------------------------------
410
Blastp_CBE
39.88
37%
-9
- C1 -
-
4EL9
1
KS6A3_MOUSE
A:
[18-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
-
A
D
P
-----
S
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
ISG
S
---
D
A
R
Q
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
-
R
D
R
V
-----
R
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
-----
E
K
----
K
----
A
Y
---------
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
A
G
-
P
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------------------
498
Blastp_CBE
39.40
38%
-5
- C1 -
-
6G78
1
KS6A6_HUMAN
A:
[26-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
-----
A
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
--
K
V
-
R
D
--------
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
VDQ-------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
N
E
-----
T
M
N
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
---
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------------------
367
Blastp_CBE
38.62
40%
-9
- C1 -
-
3A61
1
KS6B1_HUMAN
A:
[19-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
G
K
-
I
F
A
M
K
V
L
----------------
K
A
E
R
N
I
L
-
E
-
E
V
---
K
---
H
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
-------------------------------------------------------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
----
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
------------------------------------------------------------------
386
Blastp_CBE
38.22
40%
-18
- C1 -
-
4RLO
4
KS6B1_HUMAN
B:
[7-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
G
K
-
I
F
A
M
K
V
L
K
K
-----------------------------
K
---
H
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
S
I----------------------------------
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
----
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
------------------------------------------------------------------
391
Blastp_CBE
38.14
37%
-10
- C1 -
-
2Z7S
1
KS6A1_HUMAN
A:
[25-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
-----
S
---------------
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
KVT
R
---
P
---
D
S
G
H
-
L
Y
A
M
K
V
L
-
K
-------------------
I
L
-
A
-
D
V
---
N
---
H
P
-
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
-------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
L
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
-
S
G
-
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
------------------------------------------------------------------
529
Blastp_CBE
38.01
38%
-21
- C1 -
-
6G76
1
KS6A6_HUMAN
B:
[26-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
-----
A
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
--
K
V
----------
R
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
---
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
VD----------------------------------
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
N
E
-----
T
----------------
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
---
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------------------
378
Blastp_CBE
37.21
40%
-5
- C1 -
-
3WF5
1
KS6B1_HUMAN
A:
[21-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
G
K
-
I
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
-
E
-
E
V
---
K
---
H
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
S
IH---
D
G
----
T
----
V
T
---------
H
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
----
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
--------------
S
------------------------------------------------
392
Blastp_CBE
36.91
37%
-1
- C1 -
-
2Z7R
1
KS6A1_HUMAN
A:
[25-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
-----
S
---------------
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
KVT
R
---
P
---
D
S
G
H
-
L
Y
A
M
K
V
L
-
K
K
A
T
L
-
K
V
------------
I
L
-
A
-
D
V
---
N
---
H
P
-
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
-------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
L
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
-
S
G
-
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
------------------------------------------------------------------
368
Blastp_CBE
36.86
40%
-10
- C1 -
-
3A60
1
KS6B1_HUMAN
B:
[19-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
G
K
-
I
F
A
M
K
V
L
K
K
-----------------------------
K
---
H
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
S
-----------------------------
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
----
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
-----------------------------------------------------------------
377
Blastp_CBE
36.83
40%
-3
- C1 -
-
3WF6
1
KS6B1_HUMAN
A:
[21-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
---
N
T
G
K
-
I
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
-
E
-
E
V
---
K
---
H
P
-
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
-
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------------------------
K
---
E
--
S
IH---
D
G
----
T
----
V
T
---------
H
F
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
----
N
R
--
K
K
-----
T
I
D
K
I
L
K
C
------
K
--
L
N
--
L
P
-----
P
Y
--
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
G
-
A
G
-
P
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
--------------
S
------------------------------------------------
393
Blastp_CBE
36.71
37%
-13
- C1 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[25-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
-----
S
---------------
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
KVT
R
---
P
---
D
S
G
H
-
L
Y
A
M
K
V
L
---------------------
I
L
-
A
-
D
V
---
N
---
H
P
-
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
-
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
-------------------------------------
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
----
Q
G
K
----
D
R
--
K
E
-----
T
M
T
L
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
G
-
S
G
-
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
------------------------------------------------------------------
530
Blastp_CBE
35.34
38%
-7
- C1 -
-
6G76
2
KS6A6_HUMAN
A:
[26-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
-----
A
---------------
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
---
K
TGP
D
A
G
Q
-
L
Y
A
M
K
V
L
K
K
A
S
L
--
K
V
-
R
D
--------
D
I
L
-
V
-
E
V
---
N
---
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
-
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
-----------------------------
K
---
E
--
S
VD---
Q
E
----
K
----
K
A
---------
Y
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
--
R
R
---
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
----
D
R
--
N
E
-----
T
M
N
M
I
L
K
A
------
K
--
L
G
--
M
P
-----
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
G
-
S
---
E
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
------------------------------------------------------------------
362
Blastp_CBE
22.89
41%
9
- C1 -
-
6HHF
1
AKT1_HUMAN
A:
[31-439]
-----------------------------------------------------------------------------------------------------------------------------------
Q
A
A
A
E
M
-------------
D
F
R
S
G
S
P
S
D
N
S
-
G
A
E
-----
E
MEVSLAKPKHRVTMN
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
---
A
T
G
R
-
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
---
R
---
H
P
-
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
------------------------
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------
K
---
E
GI
K
-----
D
G
----
A
----
T
M
K--------
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
--
D
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
-------------------------
E
K
-----
L
F
E
L
I
L
M
E
------
E
--
I
R
--
F
P
-----
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
-
G
G
-
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
--------------
S
E
T
D
T
R
Y
F
D
-
E
--------------------------------------