@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KPCI_HUMAN: (2021-11-23 )
MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
Atome Classification :
(353 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......-230.--------......240.......250.......260.......270-.---....----..280.....-..-290........300......--.310.--........320.......330.......340....-...350.......360.......370-.-.......380.......390.......400--.........410.-......420.......-----430.......440.......450.---......460.......470...--.--...480--..---.....490.......500.......510.......520.......530.......540.......550.......560..-....--.570...---.-..---.580.......590....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPTQRDSSTM
S
H
T
VAGGGSGDHS
H
Q
V
R
V
K
A
Y
Y
RG
D
I
M
I
T
HFEPSI
S
F
E
G
L
C
N
E
V
R
D
M
CSFDNE
Q
L
F
T
M
K
W
IDEEGDPCTV
S
S
Q
L
E
L
E
E
A
F
R
L
YELNKDS
E
L
L
I
H
V
FPCVPERPGMPCPGE
D
K
S
I
Y
R
R
G
A
R
R
W
R
K
LYCANG
H
T
F
Q
A
K
RFNRRA
H
C
A
I
C
T
D
R
I
WGLGRQ
G
Y
K
C
I
N
C
K
L
L
V
H
KKC
H
K
L
V
T
I
ECGRHSLPQEPVMPM
D
Q
SSMHSDHA
Q
T
V
IPYNPSS
H
E
S
L
D
Q
-VG
E
E
--------
K
E
AMNTRESGKASSSLGL
Q
D
F
D
L
L
R
V
IGRG
S
Y
A
K
V
L
L
V
R
-L---KKTD----R
I
Y
A
M
K
V
V
K
K
-
E
L-VN-DDEDI
D
W
V
Q
T
E
K
H
V
F
E
Q--AS--N--H
P
F
L
V
G
L
H
S
C
FQTE
S
R
L
F
F
V
I
E
YVNGG
D
L
M
F
H
M
Q
R
-
Q
RKL
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-E-R-G
I
I
Y
R
D
L
K
L
D
N
V
L
LDSEG
H
I
K
LT
D
Y
G
M
C
----KEGLRPGDTTSTF-CGTPNYI
A
P
E
ILRGED-----YGF
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
AGRS
P
F
---
D
I
VGSSDNPDQ
N
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
QIRIP--RS---L
S
V
K
A
A
S
V
L
K
S
F
LNK
D
P
K
E
RLGCHPQTGFADIQGHPFFRNV
D
W
D
M
M
E
QKQVVPPFKPNISGEFGLDNF
D
S
QFTNE
P
V
Q
LT-PD
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E---FE
G
F
E
Y
I
N
P
L
L
M
S
A
E
ECV
8
PsiBlast_PDB
89.75
98%
-115
- C2 -
-
3A8X
-
KPCI_HUMAN
A:
[3-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
V
G
S
-------
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
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P
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L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
563
HHSearch
89.12
100%
-114
- C2 -
-
3A8X
-
KPCI_HUMAN
A:
[7-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
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E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
V
G
S
-------
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
5
PsiBlast_PDB
89.11
99%
-114
- C2 -
-
5LI9
13
KPCI_HUMAN
A:
[2-343]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---------------
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
L
-------
560
HHSearch
89.09
100%
-115
- C2 -
-
5LI9
13
KPCI_HUMAN
A:
[3-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---------------
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
L
-------
3
PsiBlast_PDB
89.08
99%
-121
- C2 -
-
5LIH
3
KPCI_HUMAN
A:
[1-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
--------
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
--------
Q
N
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
7
PsiBlast_PDB
88.79
98%
-119
- C2 -
-
3A8W
1
KPCI_HUMAN
A:
[3-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
-----------
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
1
PsiBlast_PDB
88.77
98%
-117
- C2 -
-
4DC2
1
KPCI_MOUSE
A:
[49-387]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
R
V
V
K
K
-
E
L
-
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
V
G
S
------
N
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
---------
561
HHSearch
88.14
100%
-110
- C2 -
-
5LI1
2
KPCI_HUMAN
A:
[6-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
----------
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
L
-------
4
PsiBlast_PDB
87.97
98%
-109
- C2 -
-
5LI1
2
KPCI_HUMAN
A:
[4-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
S
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
----------
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
L
-------
28
Blastp_CBE
87.10
99%
-111
- C2 -
-
3A8W
1
KPCI_HUMAN
B:
[3-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
---
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
-----------
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
21
Blastp_CBE
85.86
99%
-119
- C2 -
-
5LIH
3
KPCI_HUMAN
B:
[2-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-----------
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
-----------
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
6
PsiBlast_PDB
84.89
99%
-113
- C2 -
-
3ZH8
4
KPCI_HUMAN
A:
[1-343]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
V
--------
N
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
---------------
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
L
M
------
23
Blastp_CBE
84.04
99%
-108
- C2 -
-
3ZH8
5
KPCI_HUMAN
B:
[1-342]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
V
--------
N
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
--------
Q
F
T
--------
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
L
-------
22
Blastp_CBE
83.22
99%
-108
- C2 -
-
3ZH8
3
KPCI_HUMAN
C:
[1-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
V
--------
N
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
------------
Q
F
T
--------
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
9
PsiBlast_PDB
82.18
98%
-110
- C2 -
-
6ILZ
1
KPCI_HUMAN
A:
[11-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
------
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
-----------
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
---------
2
PsiBlast_PDB
81.81
98%
-121
- C2 -
-
1ZRZ
-
KPCI_HUMAN
A:
[17-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
T
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
------------
D
Q
N
T
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
M
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
L
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
-------------------
V
Q
L
T
-
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
26
Blastp_CBE
81.05
99%
-112
- C2 -
-
6ILZ
1
KPCI_HUMAN
C:
[11-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
------
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
------------
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
--
N
E
P
V
Q
L
--
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
24
Blastp_CBE
80.41
99%
-113
- C2 -
-
6ILZ
1
KPCI_HUMAN
G:
[11-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
------
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
I
-----------
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
---
F
G
L
D
N
F
D
S
Q
F
--
E
P
V
Q
L
--
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
25
Blastp_CBE
79.25
99%
-108
- C2 -
-
6ILZ
1
KPCI_HUMAN
E:
[12-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
-
L
------
D
----
R
I
Y
A
M
K
V
V
K
K
-
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
--
A
S
--
N
--
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
----
K
E
G
L
R
P
G
D
T
T
S
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
---
D
------------
E
D
Y
L
F
Q
V
I
L
--
E
--
K
Q
I
R
I
P
--
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
--
E
P
V
Q
L
--
P
D
D
D
--
D
I
V
R
K
I
D
---
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
--------
568
HHSearch
74.54
52%
-112
- C2 -
-
2I0E
-
KPCB_HUMAN
A:
[19-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
-
R
---
K
G
T
D
----
E
L
Y
A
V
K
I
L
K
K
-
D
V
-
V
I
-
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
--
P
G
--
K
--
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
-
S
-
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
I
W
D
G
V
T
T
K
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
---
E
G
E
D
E
---------
D
E
L
F
Q
S
I
M
--
E
--
H
N
V
A
Y
P
--
K
S
---
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
C
G
P
-
E
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
C
G
R
---
E
N
F
D
R
F
F
T
R
H
P
P
V
L
T
-
P
P
D
Q
--
E
V
I
R
N
I
D
---
Q
-
S
E
---
F
E
G
F
S
F
V
N
S
E
F
L
K
P
----
11
PsiBlast_PDB
73.95
50%
-120
- C2 -
-
3PFQ
1
KPCB_RAT
A:
[292-670]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
-
R
---
K
G
T
D
----
E
L
Y
A
V
K
I
L
K
K
-
D
V
-
V
I
-
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
--
P
G
--
K
--
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
-
S
-
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
I
W
D
G
V
T
T
K
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
------------
E
G
E
D
E
D
E
L
F
Q
S
I
M
--
E
--
H
N
V
A
Y
P
--
K
S
---
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
C
G
P
E
-
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
S
G
R
-
N
A
E
N
F
D
R
F
F
T
R
H
P
P
V
L
T
-
P
P
D
Q
--
E
V
I
R
N
I
D
---
Q
-
S
E
---
F
E
G
F
S
F
V
N
S
E
F
L
K
P
----
559
HHSearch
73.88
52%
-122
- C2 -
-
3PFQ
1
KPCB_RAT
A:
[292-670]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
-
R
---
K
G
T
D
----
E
L
Y
A
V
K
I
L
K
K
-
D
V
-
V
I
-
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
--
P
G
--
K
--
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
-
S
-
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
I
W
D
G
V
T
T
K
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
---
E
G
E
D
E
---------
D
E
L
F
Q
S
I
M
--
E
--
H
N
V
A
Y
P
--
K
S
---
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
C
G
P
-
E
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
S
-
G
R
N
A
E
N
F
D
R
F
F
T
R
H
P
P
V
L
T
-
P
P
D
Q
--
E
V
I
R
N
I
D
---
Q
-
S
E
---
F
E
G
F
S
F
V
N
S
E
F
L
K
P
----
562
HHSearch
73.60
45%
-112
- C2 -
-
4RA5
3
KPCT_HUMAN
A:
[3-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
-
F
---
K
K
T
N
----
Q
F
F
A
I
K
A
L
K
K
-
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
--
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
M
L
G
D
A
K
T
N
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
---
H
G
Q
D
E
---------
E
E
L
F
H
S
I
R
--
M
--
D
N
P
F
Y
P
--
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
-
F
A
D
R
--
A
L
I
N
S
M
D
---
Q
-
N
M
---
F
R
N
F
S
F
M
N
P
G
M
-------
567
HHSearch
72.45
48%
-124
- C2 -
-
2JDO
2
AKT2_HUMAN
A:
[7-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
--
T
---
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
---------
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
-
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
----------------------
M
---
F
E
D
F
D
Y
I
A
D
---------
571
HHSearch
72.42
53%
-121
- C2 -
-
4RA4
1
KPCA_HUMAN
A:
[16-348]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
K
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
A
D
-
R
---
K
G
T
E
----
E
L
Y
A
I
K
I
L
K
K
-
D
V
-
V
I
-
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
--
L
D
--
K
--
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
-
K
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
----
K
E
H
M
M
D
G
V
T
T
R
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
P
-----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
P
P
F
---
D
G
E
D
E
---------
D
E
L
F
Q
S
I
M
--
E
--
H
N
V
S
Y
P
--
K
S
---
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
L
G
C
G
P
-
E
G
E
R
D
V
R
E
H
A
F
F
R
R
I
D
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
----------------
G
Q
P
V
L
T
-
P
P
D
Q
--
L
V
I
A
N
I
D
---
Q
-
S
D
---
F
E
G
F
S
Y
V
N
P
Q
F
V
H
-----
565
HHSearch
72.16
52%
-122
- C2 -
-
3TXO
1
KPCL_HUMAN
A:
[23-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
-
V
---
K
E
T
G
----
D
L
Y
A
V
K
V
L
K
K
-
D
V
-
I
L
-
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
--
A
R
--
N
--
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
-
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
----
K
E
G
I
----------
C
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
---
E
A
E
N
E
---------
D
D
L
F
E
A
I
L
--
N
--
D
E
V
V
Y
P
--
T
W
---
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
-
P
I
D
E
--
G
H
L
P
M
I
N
---
Q
-
D
E
---
F
R
N
F
E
Y
V
S
P
---------
10
PsiBlast_PDB
72.15
52%
-120
- C2 -
-
4RA4
1
KPCA_HUMAN
A:
[19-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
A
D
-
R
---
K
G
T
E
----
E
L
Y
A
I
K
I
L
K
K
-
D
V
-
V
I
-
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
--
L
D
--
K
--
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
-
K
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
G
H
I
K
I
A
D
F
G
M
C
----
K
E
H
M
M
D
G
V
T
T
R
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
P
-----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
P
P
F
------------
D
G
E
D
E
D
E
L
F
Q
S
I
M
--
E
--
H
N
V
S
Y
P
--
K
S
---
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
L
G
C
G
P
E
-
G
E
R
D
V
R
E
H
A
F
F
R
R
I
D
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
----------------
G
Q
P
V
L
T
-
P
P
D
Q
--
L
V
I
A
N
I
D
---
Q
-
S
D
---
F
E
G
F
S
Y
V
N
P
---------
14
PsiBlast_PDB
71.72
50%
-121
- C2 -
-
3TXO
1
KPCL_HUMAN
A:
[23-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
-
V
---
K
E
T
G
----
D
L
Y
A
V
K
V
L
K
K
-
D
V
-
I
L
-
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
--
A
R
--
N
--
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
-
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
----
K
E
G
I
----------
C
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
------------
E
A
E
N
E
D
D
L
F
E
A
I
L
--
N
--
D
E
V
V
Y
P
--
T
W
---
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
-
P
I
D
E
--
G
H
L
P
M
I
N
---
Q
-
D
E
---
F
R
N
F
E
Y
V
S
P
---------
17
PsiBlast_PDB
71.58
46%
-119
- C2 -
-
2JDO
2
AKT2_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-----------------------M--
F
E
D
F
D
Y
I
-----------
80
Blastp_CBE
70.85
43%
-102
- C2 -
-
5F9E
1
KPCT_HUMAN
A:
[15-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
-
F
---
K
K
T
N
----
Q
F
F
A
I
K
A
L
K
K
-
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
--
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
M
L
G
D
A
K
T
N
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
------------
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
--
D
N
P
F
Y
P
--
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
F
-
A
-
D
R
--
A
L
I
N
S
M
D
---
Q
-
N
M
---
F
R
N
F
-
F
M
N
P
---------
65
Blastp_CBE
70.84
44%
-105
- C2 -
-
4RA5
3
KPCT_HUMAN
A:
[1-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
-
F
---
K
K
T
N
----
Q
F
F
A
I
K
A
L
K
K
-
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
--
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
M
L
G
D
A
K
T
N
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
------------
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
--
D
N
P
F
Y
P
--
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
F
-
A
-
D
R
--
A
L
I
N
S
M
D
---
Q
-
N
M
---
F
R
N
F
-
F
M
N
P
---------
20
PsiBlast_PDB
70.82
46%
-123
- C2 -
-
2X39
1
AKT2_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-----------------------QEM
F
E
D
F
D
Y
I
-----------
18
PsiBlast_PDB
70.71
46%
-122
- C2 -
-
2JDR
1
AKT2_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-----------------------QEM
F
E
D
F
D
Y
I
-----------
67
Blastp_CBE
70.51
44%
-100
- C2 -
-
4Q9Z
1
KPCT_HUMAN
A:
[2-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
-
F
---
K
K
T
N
----
Q
F
F
A
I
K
A
L
K
K
-
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
--
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
M
L
G
D
A
K
T
N
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
------------
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
--
D
N
P
F
Y
P
--
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
F
-
A
-
D
R
--
A
L
I
N
S
M
D
---
Q
-
N
M
---
F
R
N
F
-
F
M
N
P
---------
19
PsiBlast_PDB
69.83
46%
-119
- C2 -
-
2UW9
1
AKT2_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-----------------------QEM
F
E
D
F
D
Y
I
-----------
64
Blastp_CBE
69.51
44%
-117
- C2 -
-
4RA5
1
B:
[2-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
-
F
---
K
K
T
N
----
Q
F
F
A
I
K
A
L
K
K
-
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
--
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
M
L
G
D
A
K
T
N
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
------------
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
--
D
N
P
F
Y
P
--
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
------------
P
R
L
----
D
R
--
A
L
I
N
S
M
D
---
Q
-
N
M
---
F
R
N
F
-
F
M
N
P
---------
66
Blastp_CBE
67.97
44%
-118
- C2 -
-
4Q9Z
1
B:
[1-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
-
F
---
K
K
T
N
----
Q
F
F
A
I
K
A
L
K
K
-
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
--
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
M
L
G
D
A
K
T
N
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
------------
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
--
D
N
P
F
Y
P
--
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
-----------------------------
N
M
---
F
R
N
F
-
F
M
N
P
---------
77
Blastp_CBE
67.88
43%
-107
- C2 -
-
2JED
1
B:
[15-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
-
F
---
K
K
T
N
----
Q
F
F
A
I
K
A
L
K
K
-
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
--
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
M
L
G
D
A
K
T
N
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
------------
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
--
D
N
P
F
Y
P
--
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
---------------
P
R
L
F
-
A
-
D
R
--
A
L
I
N
S
M
D
---
Q
-
N
M
---
F
R
N
F
-
F
M
N
P
---------
139
Blastp_CBE
67.80
38%
-108
- C2 -
-
2UZT
1
KAPCA_BOVIN
A:
[5-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
---
R
V
K
G
R
T
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
136
Blastp_CBE
67.30
38%
-105
- C2 -
-
2UZW
1
KAPCA_BOVIN
E:
[5-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
---
R
V
K
G
R
T
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
137
Blastp_CBE
66.80
38%
-99
- C2 -
-
2UZV
1
KAPCA_BOVIN
A:
[5-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
---
R
V
K
G
R
T
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
138
Blastp_CBE
66.77
38%
-102
- C2 -
-
2UZU
1
KAPCA_BOVIN
E:
[5-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
---
R
V
K
G
R
T
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
79
Blastp_CBE
66.36
43%
-123
- C2 -
-
5F9E
1
B:
[16-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
-
F
---
K
K
T
N
----
Q
F
F
A
I
K
A
L
K
K
-
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
--
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
M
L
G
D
A
K
T
N
E
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
------------
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
--
D
N
P
F
Y
P
--
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
---------------------------------------
N
M
---
F
R
N
F
-
F
M
N
P
---------
566
HHSearch
65.79
45%
-130
- C2 -
-
1XJD
1
A:
[16-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
-
F
---
K
K
T
N
----
Q
F
F
A
I
K
A
L
K
K
-
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
--
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
M
L
G
D
A
K
T
N
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
---
H
G
Q
D
E
---------
E
E
L
F
H
S
I
R
--
M
--
D
N
P
F
Y
P
--
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
--------------------------------------------
Q
-
N
M
---
F
R
N
F
S
F
------------
578
HHSearch
64.45
46%
-40
- C2 -
-
4GV1
5
AKT1_HUMAN
A:
[6-336]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
--
S
---
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
D
H
---------
E
K
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
-
P
---SM
E
C
V
D
S
E
R
---
R
-
P
H
---
F
P
Q
F
D
Y
S
A
----------
547
Fugue
63.68
32%
-28
- C2 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
-----------------------
T
N
G
Q
C
F
--------------
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
------------------------
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
------------------------------------------------------------------------------------------------------------
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
-
L
---
K
N
A
D
----
K
V
F
A
M
K
I
L
N
K
-
W
E
-
M
L
-
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
--
G
D
--
S
---
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
-
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
----
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GGKGR
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
-------
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
--
F
--
Q
F
P
T
Q
V
--
T
D
---
V
S
E
N
A
K
D
L
I
R
R
L
I
-
C
S
R
E
H
R
L
G
---
Q
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
R
N
C
E
A
--
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
--------------------
V
D
S
G
H
---
H
-
L
P
---
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
576
HHSearch
62.64
44%
-142
- C2 -
-
2R5T
1
SGK1_HUMAN
A:
[36-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
-
H
---
K
A
E
E
----
V
F
Y
A
V
K
V
L
Q
K
-
K
A
-
I
L
--------------
V
L
L
K
--
N
V
--
K
--
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
----
K
E
N
I
E
H
N
S
T
T
S
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
---
Y
S
R
N
T
---------
A
E
M
Y
D
N
I
L
--
N
--
K
P
L
Q
L
K
--
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
577
HHSearch
62.04
44%
-132
- C2 -
-
3HDM
1
SGK1_HUMAN
A:
[36-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
-
H
---
K
A
E
E
----
V
F
Y
A
V
K
V
L
Q
K
-
K
A
-
I
L
--------------
V
L
L
K
--
N
V
--
K
--
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
----
K
E
N
I
E
H
N
S
T
T
S
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
---
Y
S
R
N
T
---------
A
E
M
Y
D
N
I
L
--
N
--
K
P
L
Q
L
K
--
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
84
Blastp_CBE
61.44
43%
-140
- C2 -
-
2R5T
1
SGK1_HUMAN
A:
[39-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
-
H
---
K
A
E
E
----
V
F
Y
A
V
K
V
L
Q
K
-
K
A
-
I
L
--------------
V
L
L
K
--
N
V
--
K
--
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
----
K
E
N
I
E
H
N
S
T
T
S
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
---
Y
--------
S
R
N
T
A
E
-
M
Y
D
N
I
L
--
N
--
K
P
L
Q
L
K
--
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
104
Blastp_CBE
61.33
41%
-30
- C2 -
-
4OTG
1
A:
[7-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
-
F
---
R
P
S
G
----
E
L
F
A
I
K
A
L
K
K
-
G
D
-
I
V
-
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
VT
S
A
--
G
--
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
-
E
-
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
C
----
K
E
G
M
G
Y
G
D
R
T
S
T
F
-
C
G
T
P
E
F
L
A
P
E
V
L
T
D
T
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
-----------
P
G
D
D
E
E
E
-
V
F
D
S
I
V
--
N
--
D
E
V
R
Y
P
--
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
S
E
R
D
A
-
E
D
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
------------
F
T
G
E
A
P
T
L
P
-
P
R
D
A
--
R
P
L
T
A
A
E
---
Q
-
A
A
---
F
L
D
F
D
F
V
-----------
131
Blastp_CBE
61.14
38%
-18
- C2 -
-
2OJF
1
KAPCA_BOVIN
E:
[16-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
---
R
V
K
G
R
T
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
135
Blastp_CBE
61.12
38%
-17
- C2 -
-
2F7E
1
KAPCA_BOVIN
E:
[16-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
---
R
V
K
G
R
T
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
134
Blastp_CBE
61.11
38%
-17
- C2 -
-
2F7X
1
KAPCA_BOVIN
E:
[16-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
---
R
V
K
G
R
T
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
83
Blastp_CBE
60.67
43%
-129
- C2 -
-
3HDM
1
SGK1_HUMAN
A:
[39-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
-
H
---
K
A
E
E
----
V
F
Y
A
V
K
V
L
Q
K
-
K
A
-
I
L
--------------
V
L
L
K
--
N
V
--
K
--
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
----
K
E
N
I
E
H
N
S
T
T
S
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
---
Y
--------
S
R
N
T
A
E
-
M
Y
D
N
I
L
--
N
--
K
P
L
Q
L
K
--
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
132
Blastp_CBE
60.52
38%
-16
- C2 -
-
2OH0
1
KAPCA_BOVIN
E:
[16-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
---
R
V
K
G
R
T
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
541
Blastp_CBE
60.48
34%
-128
- C2 -
-
3QD3
3
PDPK1_HUMAN
A:
[33-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
-
E
---
L
A
T
S
----
R
E
Y
A
I
K
I
L
E
K
-
R
H
-
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--
L
---
D
--
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
-
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
----
K
V
-
L
S
------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
------------
R
A
G
N
E
Y
L
I
F
Q
K
I
I
--
K
--
L
E
Y
D
F
P
--
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
477
Blastp_CBE
60.46
34%
-128
- C2 -
-
1UU9
8
PDPK1_HUMAN
A:
[9-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
-
E
---
L
A
T
S
----
R
E
Y
A
I
K
I
L
E
K
-
R
H
-
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--
L
---
D
--
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
-
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
----
K
-
V
L
S
------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
------------
R
A
G
N
E
Y
L
I
F
Q
K
I
I
--
K
--
L
E
Y
D
F
P
--
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
492
Blastp_CBE
60.20
34%
-129
- C2 -
-
3NUY
5
PDPK1_HUMAN
A:
[8-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
-
E
---
L
A
T
S
----
R
E
Y
A
I
K
I
L
E
K
-
R
H
-
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--
L
---
D
--
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
-
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
----
K
-
V
L
S
------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
------------
R
A
G
N
E
Y
L
I
F
Q
K
I
I
--
K
--
L
E
Y
D
F
P
--
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
493
Blastp_CBE
60.16
34%
-127
- C2 -
-
3NUU
5
PDPK1_HUMAN
A:
[8-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
-
E
---
L
A
T
S
----
R
E
Y
A
I
K
I
L
E
K
-
R
H
-
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--
L
---
D
--
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
-
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
----
K
-
V
L
S
------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
------------
R
A
G
N
E
Y
L
I
F
Q
K
I
I
--
K
--
L
E
Y
D
F
P
--
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
82
Blastp_CBE
60.01
43%
-139
- C2 -
-
3HDN
1
SGK1_HUMAN
A:
[39-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
-
H
---
K
A
E
E
----
V
F
Y
A
V
K
V
L
Q
K
-
K
A
-
I
L
--------------
V
L
L
K
--
N
V
--
K
--
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
----
K
E
N
I
E
H
N
S
T
T
S
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
---
Y
--------
S
R
N
T
A
E
-
M
Y
D
N
I
L
--
N
--
K
P
L
Q
L
K
--
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----------------------------------------------------------------
133
Blastp_CBE
59.99
38%
-17
- C2 -
-
2F7Z
1
KAPCA_BOVIN
E:
[16-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
---
R
V
K
G
R
T
W
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
70
Blastp_CBE
59.87
47%
-54
- C2 -
-
6S9W
1
?
A:
[110-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
--
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
K
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
------------------------------------------------
494
Blastp_CBE
59.84
34%
-126
- C2 -
-
3NUS
5
PDPK1_HUMAN
A:
[8-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
-
E
---
L
A
T
S
----
R
E
Y
A
I
K
I
L
E
K
-
R
H
-
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--
L
---
D
--
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
-
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
----
K
-
V
L
S
------
N
F
-
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
------------
R
A
G
N
E
Y
L
I
F
Q
K
I
I
--
K
--
L
E
Y
D
F
P
--
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
41
Blastp_CBE
59.64
47%
-70
- C2 -
-
3D0E
1
AKT2_HUMAN
B:
[4-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
P
-
P
D
R
-------------
Q
R
T
H
---
F
P
Q
F
D
Y
------------
40
Blastp_CBE
59.54
47%
-70
- C2 -
-
3E87
1
AKT2_HUMAN
A:
[4-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
P
-
P
D
--------------
Q
R
T
H
---
F
P
Q
F
D
Y
------------
39
Blastp_CBE
59.46
47%
-70
- C2 -
-
3E87
1
AKT2_HUMAN
B:
[4-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
P
-
P
D
--------------
Q
R
T
H
---
F
P
Q
F
D
Y
------------
542
Blastp_CBE
59.42
34%
-125
- C2 -
-
3QD0
6
PDPK1_HUMAN
A:
[33-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
-
E
---
L
A
T
S
----
R
E
Y
A
I
K
I
L
E
K
-
R
H
-
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
S
R
--
L
---
D
--
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
-
G
-
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
M
H
I
Q
I
T
D
F
G
T
A
----
K
V
-
L
S
----------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
------------
R
A
G
N
E
Y
L
I
F
Q
K
I
I
--
K
--
L
E
Y
D
F
P
--
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
E
M
E
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
W
E
N
L
H
Q
Q
--
T
P
P
--------------------------------------------------------------------
42
Blastp_CBE
59.40
47%
-69
- C2 -
-
3D0E
1
AKT2_HUMAN
A:
[4-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
P
-
P
D
R
-------------
Q
R
T
H
---
F
P
Q
F
D
Y
------------
32
Blastp_CBE
59.40
47%
-83
- C2 -
-
2XH5
1
AKT2_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
----------------------EM-
F
E
D
F
D
Y
I
-----------
87
Blastp_CBE
58.78
39%
11
- C2 -
-
4L43
1
KS6B1_HUMAN
A:
[10-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
V
-------------
S
A
N
---
Q
-
V
----
F
L
G
F
A
Y
V
A
P
---------
89
Blastp_CBE
58.56
39%
6
- C2 -
-
4L46
1
KS6B1_HUMAN
A:
[9-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
D
----
H
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
V
-------------------
Q
-
V
----
F
L
G
F
-
Y
V
A
P
---------
38
Blastp_CBE
58.23
47%
-69
- C2 -
-
3E88
1
AKT2_HUMAN
A:
[4-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
P
-----------------
Q
R
T
H
---
F
P
Q
F
D
Y
------------
34
Blastp_CBE
58.05
48%
-71
- C2 -
-
1O6K
1
AKT2_HUMAN
A:
[4-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
-
P
P
D
--------------------------------------
37
Blastp_CBE
57.97
47%
-68
- C2 -
-
3E88
1
AKT2_HUMAN
B:
[4-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
P
-----------------
Q
R
T
H
---
F
P
Q
F
D
Y
------------
36
Blastp_CBE
57.60
47%
-67
- C2 -
-
3E8D
1
AKT2_HUMAN
A:
[4-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
----------------------
H
---
F
P
Q
F
D
Y
------------
35
Blastp_CBE
57.59
47%
-70
- C2 -
-
3E8D
1
AKT2_HUMAN
B:
[4-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
--------------------R
T
H
---
F
P
Q
F
D
Y
------------
33
Blastp_CBE
57.56
47%
-78
- C2 -
-
1O6L
1
AKT2_HUMAN
A:
[4-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
R
K
-
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
--
N
T
--
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
S
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
R
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
----------------------EM-
F
E
D
F
D
Y
I
-----------
85
Blastp_CBE
57.46
39%
9
- C2 -
-
4L45
1
KS6B1_HUMAN
A:
[10-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
V
------------
E
S
A
N
---
Q
-
V
----
F
L
G
F
E
Y
V
A
P
---------
86
Blastp_CBE
57.39
39%
13
- C2 -
-
4L44
1
KS6B1_HUMAN
A:
[10-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
-----
H
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T
-------------
S
E
S
A
N
---
Q
-
V
----
F
L
G
F
A
Y
V
A
P
---------
573
HHSearch
57.11
42%
-41
- C2 -
-
4OTH
1
A:
[8-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
-
F
---
R
P
S
G
----
E
L
F
A
I
K
A
L
K
K
-
G
D
-
I
V
-
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
--
V
T
SA
G
--
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
-
E
-
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
C
----
K
-----------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
---
P
G
D
D
E
---------
E
E
V
F
D
S
I
V
--
N
--
D
E
V
R
Y
P
--
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
S
E
-
R
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
E
E
F
T
G
E
A
P
T
L
S
-
P
P
R
D
A-
R
P
L
T
A
A
E
---
Q
-
A
A
---
F
L
D
F
D
F
V
A
----------
359
Blastp_CBE
57.06
37%
-68
- C2 -
-
5N33
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
--
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
355
Blastp_CBE
57.02
37%
-65
- C2 -
-
5N3A
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
317
Blastp_CBE
56.93
37%
-63
- C2 -
-
6ERT
1
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
183
Blastp_CBE
56.90
37%
-67
- C2 -
-
5N7U
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
420
Blastp_CBE
56.84
37%
-68
- C2 -
-
4C35
2
KAPCA_BOVIN
A:
[20-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
330
Blastp_CBE
56.81
37%
-66
- C2 -
-
5OTG
1
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
185
Blastp_CBE
56.73
37%
-70
- C2 -
-
5N32
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
--
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
-
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
223
Blastp_CBE
56.71
37%
-66
- C2 -
-
6MM8
6
KAPCA_MOUSE
C:
[8-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
354
Blastp_CBE
56.60
37%
-69
- C2 -
-
5N3B
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
-
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
187
Blastp_CBE
56.61
37%
-69
- C2 -
-
5N1E
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
---
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
189
Blastp_CBE
56.60
37%
-69
- C2 -
-
5MHI
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
--
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
63
Blastp_CBE
56.60
43%
-90
- C2 -
-
1XJD
1
A:
[16-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
-
F
---
K
K
T
N
----
Q
F
F
A
I
K
A
L
K
K
-
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
--
A
W
--
E
--
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
----
K
E
N
M
L
-
G
D
A
K
T
N
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
------------
H
G
Q
D
E
E
E
L
F
H
S
I
R
--
M
--
D
N
P
F
Y
P
--
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
E
L
E
R
K
E
I
D
P
P
---------------------------------------------
N
M
---
F
R
N
F
-
F
M
N
----------
291
Blastp_CBE
56.58
37%
-64
- C2 -
-
1Q8T
1
KAPCA_BOVIN
A:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
358
Blastp_CBE
56.55
37%
-66
- C2 -
-
5N36
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
--
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
410
Blastp_CBE
56.50
37%
-64
- C2 -
-
1L3R
3
KAPCA_MOUSE
E:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
357
Blastp_CBE
56.48
37%
-67
- C2 -
-
5N37
6
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
309
Blastp_CBE
56.50
37%
-64
- C2 -
-
6I2H
1
?
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
199
Blastp_CBE
56.49
37%
-64
- C2 -
-
5LCT
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
315
Blastp_CBE
56.48
37%
-68
- C2 -
-
6ERW
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
---
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
208
Blastp_CBE
56.44
37%
-64
- C2 -
-
5BX6
4
KAPCA_HUMAN
A:
[20-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
362
Blastp_CBE
56.40
37%
-69
- C2 -
-
5N1M
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
--
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
193
Blastp_CBE
56.40
37%
-68
- C2 -
-
5M6V
1
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
190
Blastp_CBE
56.39
37%
-70
- C2 -
-
5M75
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
313
Blastp_CBE
56.35
37%
-65
- C2 -
-
6I2A
1
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
224
Blastp_CBE
56.35
37%
-64
- C2 -
-
6MM7
9
KAPCA_MOUSE
D:
[8-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
184
Blastp_CBE
56.34
37%
-67
- C2 -
-
5N7P
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
201
Blastp_CBE
56.27
37%
-66
- C2 -
-
5LCQ
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
421
Blastp_CBE
56.22
37%
-70
- C2 -
-
4C34
3
KAPCA_BOVIN
A:
[20-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
-
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
407
Blastp_CBE
56.25
37%
-63
- C2 -
-
4O21
1
KAPCA_MOUSE
A:
[11-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
226
Blastp_CBE
56.22
37%
-61
- C2 -
-
6MM6
1
KAPCA_MOUSE
E:
[8-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
320
Blastp_CBE
56.20
37%
-65
- C2 -
-
6EMB
1
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
192
Blastp_CBE
56.17
37%
-64
- C2 -
-
5M6Y
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
426
Blastp_CBE
56.11
37%
-65
* C2 *
-
3ZO2
4
KAPCA_BOVIN
A:
[20-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
543
Fugue
56.15
39%
-49
- C2 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
-
T
F
H
V
--------
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
V
L
-
Q
N
---------------------
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
---------------------
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
---------
N
Q
D
H
E
K
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
------------------------------------------------------
352
Blastp_CBE
56.14
37%
-67
- C2 -
-
5N3D
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
--
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
207
Blastp_CBE
56.12
37%
-67
- C2 -
-
5BX7
4
KAPCA_HUMAN
A:
[20-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
366
Blastp_CBE
56.08
37%
-66
- C2 -
-
5N1F
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
356
Blastp_CBE
56.10
37%
-67
- C2 -
-
5N39
5
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
--
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
353
Blastp_CBE
56.09
37%
-65
- C2 -
-
5N3C
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
-
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
351
Blastp_CBE
56.06
37%
-67
- C2 -
-
5N3E
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
-
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
324
Blastp_CBE
56.06
37%
-65
- C2 -
-
6EH3
1
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
289
Blastp_CBE
56.07
37%
-67
- C2 -
-
1STC
1
KAPCA_BOVIN
E:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
290
Blastp_CBE
56.06
37%
-62
- C2 -
-
1Q8U
3
KAPCA_BOVIN
A:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
188
Blastp_CBE
56.05
37%
-69
- C2 -
-
5N1D
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
--
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
348
Blastp_CBE
56.02
37%
-63
- C2 -
-
5N3H
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
335
Blastp_CBE
56.00
37%
-64
- C2 -
-
5O0E
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
202
Blastp_CBE
56.02
37%
-66
- C2 -
-
5LCP
5
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
103
Blastp_CBE
56.00
41%
-38
- C2 -
-
4OTH
1
A:
[7-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
-
F
---
R
P
S
G
----
E
L
F
A
I
K
A
L
K
K
-
G
D
-
I
V
-
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
VT
S
A
--
G
--
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
-
E
-
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
C
----
K
-----------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
-----------
P
G
D
D
E
E
E
-
V
F
D
S
I
V
--
N
--
D
E
V
R
Y
P
--
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
S
E
R
D
A
-
E
D
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
E
E
F
T
G
E
A
P
T
L
P
-
P
R
D
A
--
R
P
L
T
A
A
E
---
Q
-
A
A
---
F
L
D
F
D
F
V
-----------
363
Blastp_CBE
55.98
37%
-65
- C2 -
-
5N1L
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
--
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
346
Blastp_CBE
55.95
37%
-65
- C2 -
-
5N3J
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
200
Blastp_CBE
55.94
37%
-64
- C2 -
-
5LCR
6
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
314
Blastp_CBE
55.93
37%
-65
- C2 -
-
6ESA
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
209
Blastp_CBE
55.92
37%
-63
- C2 -
-
4UJB
3
KAPCA_HUMAN
A:
[20-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
308
Blastp_CBE
55.90
37%
-65
- C2 -
-
5NW8
2
KAPCA_CRIGR
A:
[20-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
254
Blastp_CBE
55.90
37%
-64
- C2 -
-
2GNH
2
KAPCA_BOVIN
A:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
191
Blastp_CBE
55.84
37%
-66
- C2 -
-
5M71
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
338
Blastp_CBE
55.79
37%
-63
- C2 -
-
5N3S
5
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
345
Blastp_CBE
55.73
37%
-63
- C2 -
-
5N3K
5
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
337
Blastp_CBE
55.72
37%
-65
- C2 -
-
5N3T
5
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
371
Blastp_CBE
55.68
37%
-63
- C2 -
-
4WB8
2
KAPCA_HUMAN
A:
[6-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
350
Blastp_CBE
55.68
37%
-71
- C2 -
-
5N3F
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
---
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
--
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
-
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
231
Blastp_CBE
55.68
37%
-62
- C2 -
-
1BKX
1
KAPCA_MOUSE
A:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
364
Blastp_CBE
55.67
37%
-64
- C2 -
-
5N1H
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
234
Blastp_CBE
55.66
37%
-62
- C2 -
-
1JBP
2
KAPCA_MOUSE
E:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
E
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
365
Blastp_CBE
55.63
37%
-63
- C2 -
-
5N1G
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
196
Blastp_CBE
55.63
37%
-65
- C2 -
-
5M0C
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
197
Blastp_CBE
55.60
37%
-65
- C2 -
-
5M0B
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
102
Blastp_CBE
55.60
41%
-39
- C2 -
-
4OTI
1
A:
[7-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
-
F
---
R
P
S
G
----
E
L
F
A
I
K
A
L
K
K
-
G
D
-
I
V
-
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
A
A
VT
S
A
--
G
--
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
-
E
-
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
Y
V
K
I
A
D
F
G
L
-----------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
S
P
F
-----------
P
G
D
D
E
E
E
-
V
F
D
S
I
V
--
N
--
D
E
V
R
Y
P
--
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
S
S
E
R
D
A
-
E
D
V
K
K
Q
P
F
F
R
T
L
G
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
E
E
F
T
G
E
A
P
T
L
P
-
P
R
D
A
--
R
P
L
T
A
A
E
---
Q
-
A
A
---
F
L
D
F
D
F
V
-----------
43
Blastp_CBE
55.60
46%
-25
- C2 -
-
6CCY
1
AKT1_HUMAN
A:
[1-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
L
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
S
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P----------------
Q
-
E
M
---
F
R
D
F
D
Y
I
-----------
328
Blastp_CBE
55.58
37%
-67
- C2 -
-
5OUC
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
311
Blastp_CBE
55.50
37%
-63
- C2 -
-
6I2C
1
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
--
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
422
Blastp_CBE
55.46
37%
-58
- C2 -
-
4WB6
1
KAPCA_HUMAN
A:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
419
Blastp_CBE
55.38
37%
-64
- C2 -
-
4C36
1
KAPCA_BOVIN
A:
[20-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
340
Blastp_CBE
55.36
37%
-64
- C2 -
-
5N3Q
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
195
Blastp_CBE
55.33
37%
-63
- C2 -
-
5M0L
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
344
Blastp_CBE
55.32
37%
-64
- C2 -
-
5N3L
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
333
Blastp_CBE
55.29
37%
-65
- C2 -
-
5OK3
1
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
408
Blastp_CBE
55.30
37%
-64
- C2 -
-
3PVB
1
KAPCA_MOUSE
A:
[14-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
253
Blastp_CBE
55.29
37%
-63
- C2 -
-
2GNI
1
KAPCA_BOVIN
A:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
50
Blastp_CBE
55.28
46%
-22
- C2 -
-
3OW4
1
AKT1_HUMAN
B:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
--------------------
P
H
---
F
P
Q
F
D
Y
------------
194
Blastp_CBE
55.27
37%
-66
- C2 -
-
5M0U
10
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
----
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
321
Blastp_CBE
55.22
37%
-64
- C2 -
-
6EMA
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
318
Blastp_CBE
55.22
37%
-62
- C2 -
-
6ERS
1
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
--
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
349
Blastp_CBE
55.20
37%
-64
- C2 -
-
5N3G
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
266
Blastp_CBE
55.17
37%
-59
- C2 -
-
4WB6
1
KAPCA_HUMAN
B:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
342
Blastp_CBE
55.16
37%
-62
- C2 -
-
5N3O
6
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
331
Blastp_CBE
55.13
37%
-60
- C2 -
-
5OT3
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
218
Blastp_CBE
55.04
37%
-63
- C2 -
-
2GU8
1
KAPCA_HUMAN
A:
[6-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
E
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
106
Blastp_CBE
55.04
40%
7
- C2 -
-
4L3J
1
KS6B1_HUMAN
A:
[14-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
D
G
T
V
T
H
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
186
Blastp_CBE
54.95
37%
-64
- C2 -
-
5N1K
3
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
--
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
-
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
323
Blastp_CBE
54.92
37%
-64
- C2 -
-
6EM2
2
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
409
Blastp_CBE
54.83
37%
-60
- C2 -
-
3TNQ
1
KAPCA_MOUSE
B:
[19-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
88
Blastp_CBE
54.86
39%
17
- C2 -
-
4L42
1
KS6B1_HUMAN
A:
[13-343]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
D
G
T
V
T
H
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
-------------------------------------------
E
M
---
F
R
D
F
E
Y
I
-----------
54
Blastp_CBE
54.83
46%
-19
- C2 -
-
4GV1
5
AKT1_HUMAN
A:
[3-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
-------
M
E
C
V
D
SER
R
-
P
H
---
F
P
Q
F
D
Y
------------
204
Blastp_CBE
54.77
37%
-62
- C2 -
-
3AMB
1
KAPCA_HUMAN
A:
[20-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
Q
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
N
F
D
-----------------------------------------------------
341
Blastp_CBE
54.76
37%
-63
- C2 -
-
5N3P
4
KAPCA_CRIGR
A:
[22-331]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
205
Blastp_CBE
54.64
37%
-64
- C2 -
-
3AMA
1
KAPCA_HUMAN
A:
[20-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
Q
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
N
F
D
-----------------------------------------------------
52
Blastp_CBE
54.61
46%
-21
- C2 -
-
3OCB
1
AKT1_HUMAN
B:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P------------------
P
H
---
F
P
Q
F
D
Y
------------
45
Blastp_CBE
54.59
46%
-15
- C2 -
-
4EKK
1
AKT1_HUMAN
B:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
----------------ER-
R
-
P
H
---
F
P
Q
F
D
Y
------------
439
Blastp_CBE
54.52
37%
-95
- C2 -
-
5LOH
3
GWL_HUMAN
B:
[35-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
E
F
S
I
V
K
P
I
S
R
G
A
F
G
K
V
Y
L
G
Q
------
K
G
G
----
K
L
Y
A
V
K
V
V
K
K
-
A
D
-
M
I
-
N
K
--------------
A
--
L
S
--
K
--
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
-
Y
G
Y
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
-
R
-
H
-
G
I
I
H
R
D
L
K
P
D
N
M
L
I
S
N
E
G
H
I
K
L
T
D
F
G
L
--------------------
G
T
P
D
Y
L
A
P
E
L
L
L
G
R
A
-----
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
I
P
P
F
---
N
----
D
E
T
P
Q
Q
-----
V
F
Q
N
I
L
--
K
--
R
D
I
P
W
P
--
E
G
EEK
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
R
------
A
G
M
K
E
L
K
R
H
P
L
F
S
D
V
D
W
E
N
L
Q
H
Q
T
M
--
P
F
I
P
Q
P
---------------------------------------------------------------
60
Blastp_CBE
54.49
46%
-17
- C2 -
-
6NPZ
2
AKT1_HUMAN
A:
[20-348]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
-
P
P
D
Q
--
D
----------------------------------
56
Blastp_CBE
54.46
45%
-17
- C2 -
-
3MV5
1
AKT1_HUMAN
A:
[6-336]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
---------------------
P
H
---
F
P
Q
F
D
Y
------------
57
Blastp_CBE
54.45
45%
-19
- C2 -
-
3CQW
1
AKT1_HUMAN
A:
[6-336]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
----------------R--
R
-
P
H
---
F
P
Q
F
D
Y
------------
455
Blastp_CBE
54.38
34%
-19
- C2 -
-
6BDL
1
KGP1_HUMAN
A:
[29-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
G
F
G
R
V
E
L
V
Q
-
L
---
K
S
E
E
S---
K
T
F
A
M
K
I
L
K
K
-
R
H
-
I
V
-
D
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
--
G
A
--
H
--
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
-
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
-
S
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
H
R
G
Y
A
K
L
V
D
F
G
F
A
----
K
K
-
I
G
F
G
K
K
T
-
W
F
-
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
P
P
F
-------
S
G
P
D
P
M
K
T
-----
Y
N
I
I
L
--
R
GI
D
M
I
E
F
P
--
K
K
---
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
R
L
G
-
N
L
K
N
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
S
-
F
P
E
D
N
D
E
P
P
-
P
D
D
N
-------------------------------------
325
Blastp_CBE
54.35
37%
-68
- C2 -
-
6EH2
2
KAPCA_CRIGR
A:
[22-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
---
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
--
D
T
S
N
F
D
-----------------------------------------------------
48
Blastp_CBE
54.23
46%
-18
- C2 -
-
3QKL
1
AKT1_HUMAN
A:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
--------------------
P
H
---
F
P
Q
F
D
Y
------------
105
Blastp_CBE
54.21
40%
6
- C2 -
-
4L3L
1
KS6B1_HUMAN
A:
[14-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
D
G
T
V
T
H
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
44
Blastp_CBE
54.10
46%
-14
- C2 -
-
4EKL
1
AKT1_HUMAN
A:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
-------
M
E
C
V
D
SER
R
-
P
H
---
F
P
Q
F
D
Y
------------
51
Blastp_CBE
54.02
46%
-17
- C2 -
-
3OW4
1
AKT1_HUMAN
A:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
--------------------
P
H
---
F
P
Q
F
D
Y
------------
58
Blastp_CBE
53.96
45%
-17
- C2 -
-
3CQU
1
AKT1_HUMAN
A:
[6-336]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------ER-
R
-
P
H
---
F
P
Q
F
D
Y
------------
47
Blastp_CBE
53.91
46%
-20
- C2 -
-
3QKM
1
AKT1_HUMAN
A:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
-------
M
E
C
V
D
SER
R
-
P
H
---
F
P
Q
F
D
Y
------------
454
Blastp_CBE
53.85
34%
-20
- C2 -
-
6BDL
1
KGP1_HUMAN
B:
[29-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
G
F
G
R
V
E
L
V
Q
-
L
---
K
S
E
E
S---
K
T
F
A
M
K
I
L
K
K
-
R
H
-
I
V
-
D
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
-
Q
--
G
A
--
H
--
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
-
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
-
S
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
H
R
G
Y
A
K
L
V
D
F
G
F
A
----
K
K
-
I
G
F
G
K
K
T
-
W
F
-
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
P
P
F
-------
S
G
P
D
P
M
K
T
-----
Y
N
I
I
L
--
R
GI
D
M
I
E
F
P
--
K
K
---
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
R
L
G
-
N
L
K
N
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
S
-
F
P
E
D
N
D
E
P
P
-
P
D
D
N
-------------------------------------
55
Blastp_CBE
53.84
45%
-16
- C2 -
-
3MVH
1
AKT1_HUMAN
A:
[7-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
-----------------------
P
H
---
F
P
Q
F
D
Y
------------
101
Blastp_CBE
53.80
41%
2
- C2 -
-
3WE4
1
KS6B1_HUMAN
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
D
---
V
T
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
--------------------------------------------------------------
49
Blastp_CBE
53.76
46%
-22
- C2 -
-
3QKK
1
AKT1_HUMAN
A:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
----------
E
C
V
D
SER
R
-
P
H
---
F
P
Q
F
D
Y
------------
537
Blastp_CBE
53.75
36%
-23
- C2 -
-
2ETK
1
ROCK1_HUMAN
A:
[74-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
T
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
53
Blastp_CBE
53.66
46%
-19
- C2 -
-
3OCB
1
AKT1_HUMAN
A:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
----------------------
P
H
---
F
P
Q
F
D
Y
------------
515
Blastp_CBE
53.65
36%
-20
- C2 -
-
5KKS
1
ROCK1_HUMAN
B:
[74-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
T
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
440
Blastp_CBE
53.57
37%
-98
- C2 -
-
5LOH
2
GWL_HUMAN
A:
[35-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
E
F
S
I
V
K
P
I
S
----
G
K
V
Y
L
G
Q
------
K
G
G
----
K
L
Y
A
V
K
V
V
K
K
-
A
D
-
M
----------------
L
-
A
--
L
S
--
K
--
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
-
Y
G
Y
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
-
R
-
H
-
G
I
I
H
R
D
L
K
P
D
N
M
L
I
S
N
E
G
H
I
K
L
T
D
F
G
L
S
----
K
-----------
F
-
C
G
T
P
D
Y
L
A
P
E
L
L
L
G
R
A
-----
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
I
P
P
F
---
N
----
D
E
T
P
Q
Q
-----
V
F
Q
N
I
L
--
K
--
R
D
I
P
W
P
--
E
G
EEK
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
R
------
A
G
M
K
E
L
K
R
H
P
L
F
S
D
V
D
W
E
N
L
Q
H
Q
T
M
--
P
F
I
P
Q
P
---------------------------------------------------------------
46
Blastp_CBE
53.51
46%
-15
- C2 -
-
4EKK
1
AKT1_HUMAN
A:
[5-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
-
A
T
M
K
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
-----------
Y
N
Q
D
H
E
K
-
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
----------------ER-
R
-
P
H
---
F
P
Q
F
D
Y
------------
533
Blastp_CBE
53.19
36%
-22
- C2 -
-
3D9V
1
ROCK1_HUMAN
A:
[74-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
T
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
416
Blastp_CBE
53.12
37%
-2
- C2 -
-
3BWJ
2
KAPCA_BOVIN
A:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
535
Blastp_CBE
53.04
36%
-22
- C2 -
-
2ETR
1
ROCK1_HUMAN
A:
[74-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
T
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
175
Blastp_CBE
52.96
37%
-4
- C2 -
-
4NTT
1
KAPCA_MOUSE
A:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
538
Blastp_CBE
52.79
36%
-17
- C2 -
-
2ESM
1
ROCK1_HUMAN
B:
[74-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
T
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
98
Blastp_CBE
52.78
41%
5
- C2 -
-
3WF7
2
KS6B1_HUMAN
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
D
---
V
T
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
--------------------------------------------------------------
539
Blastp_CBE
52.76
36%
-22
- C2 -
-
2ESM
1
ROCK1_HUMAN
A:
[74-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
T
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
244
Blastp_CBE
52.74
37%
-3
- C2 -
-
2C1B
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
532
Blastp_CBE
52.72
36%
-19
- C2 -
-
3D9V
1
ROCK1_HUMAN
B:
[74-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
T
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
519
Blastp_CBE
52.67
36%
-18
- C2 -
-
5BML
1
ROCK1_HUMAN
B:
[74-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
T
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
262
Blastp_CBE
52.62
37%
9
- C2 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[56-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
R
K
R
E
I
F
D
R
-
Y
G
E
E
VKEFLAKA
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
536
Blastp_CBE
52.57
36%
-22
- C2 -
-
2ETK
1
ROCK1_HUMAN
B:
[74-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
T
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
220
Blastp_CBE
52.56
37%
-2
- C2 -
-
2GNL
1
KAPCA_BOVIN
A:
[11-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
158
Blastp_CBE
52.55
37%
-0
- C2 -
-
3L9L
1
KAPCA_HUMAN
A:
[12-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
261
Blastp_CBE
52.47
37%
13
- C2 -
-
4WB7
1
DNJB1_HUMAN (first)
B:
[56-383]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
R
K
R
E
I
F
D
R
-
Y
G
E
E
VKEFLAKA
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
182
Blastp_CBE
52.46
37%
1
- C2 -
-
3L9M
1
KAPCA_HUMAN
A:
[12-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
418
Blastp_CBE
52.38
37%
-2
- C2 -
-
1Q8W
1
KAPCA_BOVIN
A:
[14-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
534
Blastp_CBE
52.40
36%
-21
- C2 -
-
2ETR
1
ROCK1_HUMAN
B:
[74-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
T
A
----
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
150
Blastp_CBE
52.38
37%
-0
- C2 -
-
4UJ1
2
KAPCA_HUMAN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
90
Blastp_CBE
52.28
44%
-30
- C2 -
-
4CRS
1
A:
[9-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
L
Q
D
F
R
C
C
A
V
L
L
R
G
H
F
G
K
V
L
L
A
E
-
Y
---
K
N
T
N
----
E
M
F
A
I
K
A
L
K
K
-
G
D
-
I
V
-
A
R
D
E
V
D
S
L
M
C
E
K
R
I
F
E
T
--
V
N
--
S
VR
H
P
F
L
V
N
L
F
A
C
F
Q
T
K
E
H
V
C
F
V
M
E
Y
A
A
G
G
D
L
M
M
H
I
H
T
-
D
--
V
F
E
P
R
A
V
F
Y
A
A
C
V
V
L
G
L
Q
Y
L
H
-
E
-
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
G
F
V
K
I
A
D
F
G
L
C
----
K
E
G
M
G
Y
G
D
R
T
S
-
F
-
C
G
T
P
E
F
L
A
P
E
V
L
T
E
T
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
I
Y
E
M
L
V
G
E
S
P
F
-----------
P
G
D
D
E
E
E
-
V
F
D
S
I
V
--
N
--
D
E
V
R
Y
P
--
R
F
---
L
S
T
E
A
I
S
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
A
S
E
K
D
A
-
E
D
V
K
K
H
P
F
F
R
L
I
D
W
S
A
L
M
D
K
K
V
K
P
P
F
I
P
T
I
R
G
R
E
D
V
S
N
F
D
D
E
F
T
S
E
A
P
I
L
P
-
P
R
E
P
--
R
I
L
S
--------------
R
D
F
D
Y
I
-----------
374
Blastp_CBE
52.27
37%
1
- C2 -
-
4WBB
1
KAPCA_MOUSE
B:
[14-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
267
Blastp_CBE
52.25
37%
-4
- C2 -
-
4YXS
1
KAPCA_BOVIN
A:
[14-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
247
Blastp_CBE
52.26
37%
-2
- C2 -
-
4IJ9
1
KAPCA_BOVIN
A:
[14-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
414
Blastp_CBE
52.21
37%
-3
- C2 -
-
2JDS
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
177
Blastp_CBE
52.25
37%
3
- C2 -
-
3MVJ
1
KAPCA_HUMAN
E:
[36-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
152
Blastp_CBE
52.21
37%
0
- C2 -
-
3P0M
1
KAPCA_HUMAN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
404
Blastp_CBE
52.20
37%
2
- C2 -
-
4DG3
1
KAPCA_MOUSE
E:
[35-349]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
172
Blastp_CBE
52.18
37%
8
- C2 -
-
1FMO
1
KAPCA_MOUSE
E:
[13-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
398
Blastp_CBE
52.09
37%
0
- C2 -
-
4IAF
1
KAPCA_MOUSE
A:
[21-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
413
Blastp_CBE
52.10
37%
-2
- C2 -
-
3ZO1
7
KAPCA_BOVIN
A:
[11-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
214
Blastp_CBE
52.09
37%
0
- C2 -
-
1CDK
2
KAPCA_PIG
B:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
F
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
155
Blastp_CBE
52.09
37%
-0
- C2 -
-
3OVV
2
KAPCA_HUMAN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
412
Blastp_CBE
52.02
37%
-3
- C2 -
-
3ZO3
12
KAPCA_BOVIN
A:
[12-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
292
Blastp_CBE
52.05
37%
2
- C2 -
-
5N3N
4
KAPCA_CRIGR
A:
[12-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
173
Blastp_CBE
52.02
37%
1
- C2 -
-
1ATP
1
KAPCA_MOUSE
E:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
142
Blastp_CBE
52.02
37%
-0
- C2 -
-
5UZK
1
KAPCA_HUMAN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
240
Blastp_CBE
52.00
37%
-3
- C2 -
-
4IE9
2
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
149
Blastp_CBE
52.00
37%
-0
- C2 -
-
4UJ2
2
KAPCA_HUMAN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
239
Blastp_CBE
51.94
37%
-3
- C2 -
-
6E99
1
KAPCA_BOVIN
A:
[19-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
141
Blastp_CBE
51.93
37%
5
- C2 -
-
6C0U
4
KAPCA_HUMAN
A:
[15-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
140
Blastp_CBE
51.92
37%
-4
- C2 -
-
6F14
2
KAPCA_CRIGR
A:
[11-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
----
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
386
Blastp_CBE
51.82
37%
-2
- C2 -
-
3X2U
1
KAPCA_MOUSE
A:
[19-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
153
Blastp_CBE
51.84
37%
3
- C2 -
-
3OXT
1
KAPCA_HUMAN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
302
Blastp_CBE
51.83
36%
4
- C2 -
-
2UW4
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
-
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
165
Blastp_CBE
51.82
37%
4
- C2 -
-
3IDC
1
KAPCA_MOUSE
A:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
257
Blastp_CBE
51.80
37%
-0
- C2 -
-
1YDS
1
KAPCA_BOVIN
E:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
147
Blastp_CBE
51.72
37%
-2
- C2 -
-
4UJA
2
KAPCA_HUMAN
A:
[14-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
380
Blastp_CBE
51.71
37%
-1
- C2 -
-
4DH1
1
KAPCA_MOUSE
A:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
258
Blastp_CBE
51.68
37%
0
- C2 -
-
1YDR
1
KAPCA_BOVIN
E:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
154
Blastp_CBE
51.68
37%
0
- C2 -
-
3OWP
1
KAPCA_HUMAN
A:
[16-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
268
Blastp_CBE
51.67
37%
-1
- C2 -
-
4YXR
1
KAPCA_BOVIN
A:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
160
Blastp_CBE
51.66
37%
5
- C2 -
-
2ERZ
1
KAPCA_MOUSE
E:
[16-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
157
Blastp_CBE
51.66
37%
-3
- C2 -
-
3L9L
1
KAPCA_HUMAN
B:
[13-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
394
Blastp_CBE
51.64
37%
0
- C2 -
-
4IAZ
1
KAPCA_MOUSE
A:
[20-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
390
Blastp_CBE
51.63
37%
1
- C2 -
-
4XW4
1
KAPCA_MOUSE
A:
[20-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
241
Blastp_CBE
51.59
37%
0
- C2 -
-
3ZO4
4
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
296
Blastp_CBE
51.57
37%
3
- C2 -
-
6EM7
4
KAPCA_CRIGR
A:
[13-331]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
E
F
L
K
K
W
E
S
P
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
436
Blastp_CBE
51.49
36%
3
- C2 -
-
2UVZ
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
428
Blastp_CBE
51.50
36%
5
- C2 -
-
2VO3
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
243
Blastp_CBE
51.49
37%
-0
- C2 -
-
2VO7
2
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
270
Blastp_CBE
51.48
37%
2
- C2 -
-
3DND
1
KAPCA_BOVIN
A:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
437
Blastp_CBE
51.44
36%
-0
- C2 -
-
2UVY
1
KAPCA_BOVIN
A:
[16-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
431
Blastp_CBE
51.40
36%
3
- C2 -
-
2UW8
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
245
Blastp_CBE
51.37
37%
-0
- C2 -
-
2C1A
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
121
Blastp_CBE
51.36
39%
3
- C2 -
-
4EL9
1
KS6A3_MOUSE
A:
[8-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
---
S
G
S
D
AR--
Q
L
Y
A
M
K
V
L
K
K
-
A
T
-
L
K
-
V
R
D
R
V
------
R
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
----
K
E
S
---
E
K
K
A
Y
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
---
G
K
D
R
K
E
T
M
T
------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
213
Blastp_CBE
51.35
37%
-1
- C2 -
-
2GNF
1
KAPCA_BOVIN
A:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
400
Blastp_CBE
51.28
37%
2
- C2 -
-
4IAC
1
KAPCA_MOUSE
A:
[21-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
299
Blastp_CBE
51.32
37%
-2
- C2 -
-
4WB5
1
KAPCA_HUMAN
A:
[13-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
434
Blastp_CBE
51.24
36%
4
- C2 -
-
2UW3
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
430
Blastp_CBE
51.24
36%
5
- C2 -
-
2VNW
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
382
Blastp_CBE
51.28
37%
6
- C2 -
-
4DG0
2
KAPCA_MOUSE
E:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
392
Blastp_CBE
51.27
37%
4
- C2 -
-
4IB1
1
KAPCA_MOUSE
A:
[19-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
221
Blastp_CBE
51.24
37%
-1
- C2 -
-
2GNJ
1
KAPCA_BOVIN
A:
[14-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
122
Blastp_CBE
51.24
39%
-3
- C2 -
-
3UBD
1
KS6A3_MOUSE
A:
[7-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
---
S
G
S
D
AR--
Q
L
Y
A
M
K
V
L
K
K
-
A
T
-
L
K
-
V
R
D
R
V
-------
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
----
K
-----
E
K
K
A
Y
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
---
G
K
D
R
K
E
T
M
T
------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
377
Blastp_CBE
51.20
37%
4
- C2 -
-
4DH7
1
KAPCA_MOUSE
A:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
156
Blastp_CBE
51.21
37%
1
- C2 -
-
3OOG
1
KAPCA_HUMAN
A:
[17-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
401
Blastp_CBE
51.16
37%
-3
- C2 -
-
4C38
4
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
179
Blastp_CBE
51.20
37%
-1
- C2 -
-
3MVJ
1
KAPCA_HUMAN
A:
[36-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
395
Blastp_CBE
51.16
37%
3
- C2 -
-
4IAY
1
KAPCA_MOUSE
A:
[21-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
415
Blastp_CBE
51.19
37%
-2
- C2 -
-
3KKV
1
KAPCA_BOVIN
A:
[13-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
432
Blastp_CBE
51.18
36%
3
- C2 -
-
2UW6
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
269
Blastp_CBE
51.16
37%
4
- C2 -
-
3DNE
1
KAPCA_BOVIN
A:
[13-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
174
Blastp_CBE
51.10
37%
4
- C2 -
-
4NTT
1
KAPCA_MOUSE
B:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
167
Blastp_CBE
51.09
37%
-1
- C2 -
-
3FJQ
1
KAPCA_MOUSE
E:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
379
Blastp_CBE
51.04
37%
-1
- C2 -
-
4DH3
1
KAPCA_MOUSE
A:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
238
Blastp_CBE
51.07
37%
6
- C2 -
-
6E9L
1
KAPCA_BOVIN
A:
[18-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
303
Blastp_CBE
51.04
36%
2
- C2 -
-
2UVX
1
KAPCA_BOVIN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
378
Blastp_CBE
51.00
37%
1
- C2 -
-
4DH5
1
KAPCA_MOUSE
A:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
114
Blastp_CBE
50.96
40%
-1
- C2 -
-
5D9K
2
KS6A3_HUMAN
A:
[32-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
---
S
G
S
D
AR--
Q
L
Y
A
M
K
V
L
K
K
-
A
T
-
L
K
-
V
R
D
R
V
R
-
T
K
M
E
R
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
----
K
-------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
---
G
K
D
R
K
E
T
M
T
------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
------
T
F
Y
F
D
P
----------------------------------------------------
396
Blastp_CBE
50.94
37%
4
- C2 -
-
4IAK
1
KAPCA_MOUSE
A:
[20-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
384
Blastp_CBE
50.90
37%
3
- C2 -
-
3X2W
1
KAPCA_MOUSE
A:
[19-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
517
Blastp_CBE
50.93
36%
-11
- C2 -
-
5HVU
1
ROCK1_HUMAN
B:
[74-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
T
R
----
K
V
Y
A
M
K
L
L
S
K
F
E
M
-
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-----
A
--
N
--
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
MKMN
K
E
G
M
V
R
C
D
--------
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
YAD
S
L
V
G
T
------------
Y
S
K
I
M
NH
K
--
N
S
L
T
F
P
DD
N
D
---
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
-----------------------------------------------------
387
Blastp_CBE
50.92
37%
2
- C2 -
-
6E21
1
KAPCA_MOUSE
A:
[21-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
375
Blastp_CBE
50.90
37%
4
- C2 -
-
4HPU
2
KAPCA_MOUSE
E:
[12-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
181
Blastp_CBE
50.88
37%
3
- C2 -
-
3L9M
1
KAPCA_HUMAN
B:
[14-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
304
Blastp_CBE
50.82
36%
1
- C2 -
-
2JDV
1
KAPCA_BOVIN
A:
[16-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
123
Blastp_CBE
50.82
41%
0
- C2 -
-
5D9L
2
KS6A3_HUMAN
A:
[32-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
---
S
G
S
D
AR--
Q
L
Y
A
M
K
V
L
K
K
-
A
T
-
L
K
-
V
R
D
R
V
R
-
T
K
M
E
R
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
----
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
---
G
K
D
R
K
E
T
M
T
------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
370
Blastp_CBE
50.78
37%
-3
- C2 -
-
3NX8
3
KAPCA_HUMAN
A:
[16-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
N
L
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
237
Blastp_CBE
50.78
37%
0
- C2 -
-
2QUR
1
KAPCA_MOUSE
A:
[11-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
P
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
A
D
-----------------------------------------------------
376
Blastp_CBE
50.79
37%
-1
- C2 -
-
4DH8
1
KAPCA_MOUSE
A:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
163
Blastp_CBE
50.78
37%
2
- C2 -
-
3OW3
1
KAPCA_MOUSE
A:
[15-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
162
Blastp_CBE
50.78
37%
6
- C2 -
-
4DIN
1
KAPCA_MOUSE
A:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
369
Blastp_CBE
50.74
37%
0
- C2 -
-
4DFX
5
KAPCA_MOUSE
E:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
161
Blastp_CBE
50.72
37%
2
- C2 -
-
4HPT
1
KAPCA_MOUSE
E:
[14-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
399
Blastp_CBE
50.61
37%
3
- C2 -
-
4IAD
1
KAPCA_MOUSE
A:
[20-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
402
Blastp_CBE
50.64
37%
-2
- C2 -
-
4C37
2
KAPCA_BOVIN
A:
[14-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
180
Blastp_CBE
50.63
37%
4
- C2 -
-
3L9N
1
KAPCA_HUMAN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
---
P
G
D
T
S
N
F
D
-----------------------------------------------------
393
Blastp_CBE
50.61
37%
3
- C2 -
-
4IB0
1
KAPCA_MOUSE
A:
[20-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
391
Blastp_CBE
50.54
37%
3
- C2 -
-
4IB3
1
KAPCA_MOUSE
A:
[18-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
113
Blastp_CBE
50.49
40%
4
- C2 -
-
5D9K
2
KS6A3_HUMAN
B:
[32-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
---
S
G
S
D
AR--
Q
L
Y
A
M
K
V
L
K
K
-
A
T
-
L
K
-
V
R
D
R
V
R
-
T
K
M
E
R
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
----
K
E
------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
---
G
K
D
R
K
E
T
M
T
------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
----------------------------------------------------
397
Blastp_CBE
50.45
37%
2
- C2 -
-
4IAI
2
KAPCA_MOUSE
A:
[21-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
295
Blastp_CBE
50.45
37%
0
- C2 -
-
6FRX
1
KAPCA_HUMAN
A:
[13-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
Q
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
N
F
D
-----------------------------------------------------
389
Blastp_CBE
50.37
37%
6
- C2 -
-
4XW5
1
KAPCA_MOUSE
A:
[20-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
166
Blastp_CBE
50.39
37%
9
- C2 -
-
3IDB
1
KAPCA_MOUSE
A:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
246
Blastp_CBE
50.37
37%
2
- C2 -
-
3QAM
1
KAPCA_MOUSE
E:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
A
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
388
Blastp_CBE
50.33
37%
4
- C2 -
-
4XW6
1
KAPCA_MOUSE
A:
[20-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
294
Blastp_CBE
50.31
37%
2
- C2 -
-
1RDQ
3
KAPCA_MOUSE
E:
[2-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
151
Blastp_CBE
50.24
37%
2
- C2 -
-
3POO
2
KAPCA_HUMAN
A:
[15-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
T
S
N
F
D
-----------------------------------------------------
383
Blastp_CBE
50.19
37%
1
- C2 -
-
2QCS
5
KAPCA_MOUSE
A:
[13-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
293
Blastp_CBE
50.17
37%
4
- C2 -
-
3FHI
1
KAPCA_MOUSE
A:
[13-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
A
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
367
Blastp_CBE
50.14
37%
0
- C2 -
-
4X6R
4
KAPCA_MOUSE
A:
[10-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
169
Blastp_CBE
50.12
37%
6
- C2 -
-
1REJ
1
KAPCA_MOUSE
A:
[16-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
373
Blastp_CBE
49.85
37%
-1
- C2 -
-
5JR7
1
KAPCA_MOUSE
A:
[13-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
411
Blastp_CBE
49.83
37%
1
- C2 -
-
5VHB
1
KAPCA_BOVIN
A:
[19-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
-----
G
D
T
S
N
F
D
-----------------------------------------------------
385
Blastp_CBE
49.79
37%
6
- C2 -
-
3X2V
1
KAPCA_MOUSE
A:
[24-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
271
Blastp_CBE
49.72
37%
3
- C2 -
-
3QAL
1
KAPCA_MOUSE
E:
[1-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Q
E
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
T
P
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
S
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
A
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-----------------------------------------------------
112
Blastp_CBE
49.63
42%
3
- C2 -
-
6G77
2
KS6A6_HUMAN
A:
[31-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
-----
K
K
T
G
PDAG
Q
L
Y
A
M
K
V
L
K
K
-
A
S
-
L
K
-
V
R
D
---------
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
----
K
E
S
V
D
Q
E
K
K
A
Y
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
--
G
K
D
R
N
E
T
M
N
-------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
111
Blastp_CBE
49.52
42%
5
- C2 -
-
6G77
2
KS6A6_HUMAN
B:
[31-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
-----
K
K
T
G
PDAG
Q
L
Y
A
M
K
V
L
K
K
-
A
S
-
L
K
-
V
R
D
---------
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
----
K
E
S
V
D
Q
E
K
K
A
Y
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
--
G
K
D
R
N
E
T
M
N
-------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
115
Blastp_CBE
48.95
39%
-11
- C2 -
-
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
---
T
R
P
D
SG--
H
L
Y
A
M
K
V
L
K
---------------------
I
L
A
D
--
V
---
N
--
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
----
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
---
G
K
D
R
K
E
T
M
T
------
L
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
-
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
117
Blastp_CBE
48.92
39%
-12
- C2 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
---
T
R
P
D
SG--
H
L
Y
A
M
K
V
L
----------------------
I
L
A
D
--
V
---
N
--
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
----
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
---
G
K
D
R
K
E
T
M
T
------
L
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
-
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
118
Blastp_CBE
48.61
42%
-8
- C2 -
-
6G78
1
KS6A6_HUMAN
B:
[31-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
-----
K
K
T
G
PDAG
Q
L
Y
A
M
K
V
L
K
K
-
A
S
-
L
K
-
V
R
D
---------
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
----
K
E
S
V
-----------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
--
G
K
D
R
N
E
T
M
N
-------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
110
Blastp_CBE
48.60
40%
-8
- C2 -
-
3G51
1
KS6A3_MOUSE
A:
[26-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
---
S
G
S
D
AR--
Q
L
Y
A
M
K
V
L
K
K
-
A
T
-
L
K
-
V
----------
R
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
----
K
E
S
I
------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
---
G
K
D
R
K
E
T
M
T
------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
116
Blastp_CBE
48.55
39%
3
- C2 -
-
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
V
---
T
R
P
D
SG--
H
L
Y
A
M
K
V
L
K
K
-
A
T
-
L
K
-
V
------------
I
L
A
D
--
V
---
N
--
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
----
K
E
-------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
---
Q
---
G
K
D
R
K
E
T
M
T
------
L
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
-
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
236
Blastp_CBE
48.06
37%
3
- C2 -
-
5VI9
1
KAPCA_BOVIN
A:
[15-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
E
F
L
A
K
A
--------
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
H
L
------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
-
H
---
M
E
T
G
----
N
H
Y
A
M
K
I
L
D
K
-
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
--
A
V
--
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
----
K
R
----
V
K
G
R
T
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
-------
F
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
--
S
--
G
K
V
R
F
P
--
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
-
T
S
N
F
D
-----------------------------------------------------
95
Blastp_CBE
48.06
41%
-0
- C2 -
-
3A62
1
KS6B1_HUMAN
A:
[19-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
----------------
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
----------
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
----------------------------------------------------------------
96
Blastp_CBE
47.66
41%
16
- C2 -
-
3WF9
2
KS6B1_HUMAN
A:
[21-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
D
G
-
T
V
T
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
---------------------------------------------------------------
119
Blastp_CBE
47.57
42%
1
- C2 -
-
6G78
1
KS6A6_HUMAN
A:
[31-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
-----
K
K
T
G
PDAG
Q
L
Y
A
M
K
V
L
K
K
-
A
S
-
L
K
-
V
R
D
---------
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
----
K
E
S
V
D
Q
---------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
--
G
K
D
R
N
E
T
M
N
-------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
100
Blastp_CBE
47.45
41%
-9
- C2 -
-
3WF5
1
KS6B1_HUMAN
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
--------------
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
D
G
-
T
V
T
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-------------------------------------------------------------
99
Blastp_CBE
46.73
41%
-7
- C2 -
-
3WF6
1
KS6B1_HUMAN
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
--------------
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
D
G
-
T
V
T
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-------------------------------------------------------------
97
Blastp_CBE
46.70
41%
15
- C2 -
-
3WF8
2
KS6B1_HUMAN
A:
[21-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
H
D
G
-
T
V
T
H
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
---------------------------------------------------------------
91
Blastp_CBE
46.17
41%
3
- C2 -
-
3A61
1
KS6B1_HUMAN
A:
[19-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
-----------------
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
---------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
93
Blastp_CBE
45.90
41%
-1
- C2 -
-
3A60
1
KS6B1_HUMAN
A:
[19-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
-
A
M
------------
K
A
E
R
N
I
L
E
E
--
V
---
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
--------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
127
Blastp_CBE
45.37
42%
-12
- C2 -
-
6G76
1
KS6A6_HUMAN
B:
[31-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
-----
K
K
T
G
PDAG
Q
L
Y
A
M
K
V
L
K
K
-
A
S
-
L
K
-
V
----------
R
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
----
K
E
S
V
D
------------
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
--
G
K
D
R
N
E
T
-------------------
L
G
M
P
--
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
92
Blastp_CBE
44.46
41%
5
- C2 -
-
3A60
1
KS6B1_HUMAN
B:
[19-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
------------------------------
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
-----------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
----------------------------------------------------------------
108
Blastp_CBE
43.21
42%
4
- C2 -
-
4RLO
4
KS6B1_HUMAN
B:
[7-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
T
G
----
K
I
F
A
M
K
V
L
K
K
---------------------------
K
-----
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
----
K
E
S
I
------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-------
T
G
E
N
R
K
K
T
I
D
K
-----
I
L
--
K
--
C
K
L
N
L
P
--
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
128
Blastp_CBE
42.17
42%
3
- C2 -
-
6G76
2
KS6A6_HUMAN
A:
[31-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
-----
K
K
T
G
PDAG
Q
L
Y
A
M
K
V
L
K
K
-
A
S
-
L
K
-
V
R
D
---------
D
I
L
V
E
--
V
---
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
-
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
G
H
I
K
L
T
D
F
G
L
S
----
K
E
S
V
D
Q
-
E
K
K
A
Y
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
---
Q
--
G
K
D
R
N
E
T
M
N
-------
M
I
L
--
K
--
A
K
L
G
M
P
--
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
E
---
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-----------------------------------------------------------------
71
Blastp_CBE
34.47
47%
22
- C2 -
-
6HHJ
1
AKT1_HUMAN
A:
[68-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
K
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
-----------------------------------------------
72
Blastp_CBE
31.12
47%
32
- C2 -
-
6HHI
1
AKT1_HUMAN
A:
[68-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
-----------------
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
---
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
K
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
-----------------------------------------------
69
Blastp_CBE
30.68
47%
33
- C2 -
-
6S9X
1
?
A:
[66-443]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
-----------------
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
----------------
Y
N
Q
D
H
---
E
K
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
-----------------------------------------------
74
Blastp_CBE
29.18
47%
34
- C2 -
-
6HHG
1
AKT1_HUMAN
A:
[68-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
-------------------
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
---
G
R
L
P
F
---------
Y
N
Q
D
H
---
E
K
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
-----------------------------------------------
75
Blastp_CBE
28.86
47%
24
- C2 -
-
6HHF
1
AKT1_HUMAN
A:
[68-439]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
-------------------
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
-----------------------
Q
D
H
---
E
K
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
-----------------------------------------------
68
Blastp_CBE
25.73
47%
58
- C2 -
-
3O96
1
AKT1_HUMAN
A:
[71-432]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
P
K
H
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
-
E
---
K
A
T
G
----
R
Y
Y
A
M
K
I
L
K
K
-
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
--
N
S
--
R
--
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
----------
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
----
K
E
G
I
K
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
-----------------------
Y
N
Q
D
H
---
E
K
L
F
E
L
I
L
--
M
--
E
E
I
R
F
P
--
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
-------------------------------------------------
-
* C *
-
-
:
---------------------------------------------------------------