@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LYN_HUMAN: (2021-11-23 )
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Atome Classification :
(485 SA)
.........10........20........30........40........50........60........70........80........90..--.-.-....100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230----.----.-------.----------------------....240-----------------.......--------.-.250.......260....--.-.---.270----........280-.---....--...-290.......300.......310.......320.......330....---...340-.......350.......360.......370.......380.......390...---..---.--.400........410.......420.......430.......440......-.450.......460.......470.......480.......490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGCIKSKGKDSLSDDGVDLKTQPVRNT
E
R
T
I
Y
V
RDPTSNKQQRPV
P
E
SQLLPGQRFQTKDPEEQG
D
I
V
V
A
LYPYDGIHPDDLSFKKG
E
K
M
K
V
L
--
E
-E-HG
E
W
W
K
A
K
S
L
L
T
K
KEGFIPSN
Y
V
A
KLNTLE
T
E
E
W
F
F
K
D
I
T
R
K
D
A
E
R
QLLAPGNSA
G
A
F
L
I
RESETLKG
S
F
S
L
S
VRDFDPV
H
G
D
V
I
K
H
Y
K
I
R
SLDNG
G
Y
Y
ISPRIT
F
P
C
I
S
D
M
I
K
H
Y
Q
K
Q
A
D
G
L
C
R
R
L
E
K
ACISPKPQ----K----P-------W----------------------D
K
D
A
W
-------------------EI
P
R
E
S
I
--------
K
-
L
V
K
R
LGAG
Q
F
G
E
V
W
M
GYY--N-N---S
T
K
-----
V
A
V
K
TLKPG
T
--
M
---
S
V
Q
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
VTREE
P
I
Y
I
I
T
E
Y
MAK
G
S
L
L
D
F
L
KSDEG---
G
K
V
L
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
DF
G
L
A
R
V
IEDN---EY---T--AR-EGAKF
P
I
K
WTAPEAI
N
F
G
C
F
T
IK
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
TYGKIPYPGRT-
N
A
D
V
M
T
A
L
SQGYRMPRVENC
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
KAEERP
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
TATEGQYQQQP
532
HHSearch
92.88
76%
-102
- C3 -
-
5H0B
1
HCK_HUMAN
A:
[8-454]
----------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
21
Blastp_CBE
92.34
77%
-104
- C3 -
-
5H0B
1
HCK_HUMAN
A:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
17
PsiBlast_PDB
91.13
76%
-102
- C3 -
-
5H09
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
20
PsiBlast_PDB
91.06
76%
-100
- C3 -
-
5H0H
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
1
PsiBlast_PDB
90.85
76%
-96
- C3 -
-
1QCF
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
19
PsiBlast_PDB
90.81
76%
-99
- C3 -
-
5H0G
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
18
PsiBlast_PDB
90.14
76%
-101
- C3 -
-
5H0E
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
28
Blastp_CBE
89.43
77%
-106
- C3 -
-
3VS3
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
-------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
25
Blastp_CBE
89.15
77%
-105
- C3 -
-
3VS6
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
3
PsiBlast_PDB
89.04
76%
-100
- C3 -
-
2C0O
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
27
Blastp_CBE
88.95
77%
-105
- C3 -
-
3VS4
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
2
PsiBlast_PDB
88.91
76%
-103
- C3 -
-
2C0I
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
36
Blastp_CBE
88.86
77%
-104
- C3 -
-
2C0I
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
10
PsiBlast_PDB
88.84
76%
-100
- C3 -
-
3VS3
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
13
PsiBlast_PDB
88.80
76%
-105
- C3 -
-
3VS6
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
4
PsiBlast_PDB
88.67
76%
-100
- C3 -
-
2C0T
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
32
Blastp_CBE
88.65
77%
-106
- C3 -
-
3VRZ
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
531
HHSearch
88.63
76%
-104
- C3 -
-
2HCK
1
HCK_HUMAN
B:
[2-438]
----------------------------------------------------------------
D
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
G
A
-------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
35
Blastp_CBE
88.59
77%
-108
- C3 -
-
2C0O
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
33
Blastp_CBE
88.59
77%
-107
- C3 -
-
3VRY
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
9
PsiBlast_PDB
88.56
76%
-106
- C3 -
-
3VS2
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
---
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
38
Blastp_CBE
88.48
75%
-102
- C3 -
-
2HCK
1
HCK_HUMAN
A:
[4-438]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-------------------
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
6
PsiBlast_PDB
88.39
76%
-102
- C3 -
-
3VRZ
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
34
Blastp_CBE
88.33
77%
-104
- C3 -
-
2C0T
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
37
Blastp_CBE
88.29
75%
-104
- C3 -
-
2HCK
1
HCK_HUMAN
B:
[4-438]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-------------------
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
31
Blastp_CBE
88.14
77%
-103
- C3 -
-
3VS0
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
26
Blastp_CBE
88.01
77%
-106
- C3 -
-
3VS5
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
11
PsiBlast_PDB
87.87
76%
-102
- C3 -
-
3VS4
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
5
PsiBlast_PDB
87.73
76%
-104
- C3 -
-
3VRY
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
12
PsiBlast_PDB
87.68
76%
-106
- C3 -
-
3VS5
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
40
Blastp_CBE
87.62
75%
-101
- C3 -
-
1AD5
1
HCK_HUMAN
A:
[4-438]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-------------------
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
30
Blastp_CBE
87.49
77%
-103
- C3 -
-
3VS1
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
29
Blastp_CBE
87.29
77%
-103
- C3 -
-
3VS2
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
15
PsiBlast_PDB
87.18
76%
-102
- C3 -
-
4LUD
2
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
---
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
--
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
--------
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
8
PsiBlast_PDB
87.13
76%
-93
- C3 -
-
3VS1
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
---------
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
7
PsiBlast_PDB
86.80
76%
-102
- C3 -
-
3VS0
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
39
Blastp_CBE
86.74
75%
-101
- C3 -
-
1AD5
1
HCK_HUMAN
B:
[4-438]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-------------------
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
P
24
Blastp_CBE
86.46
77%
-96
- C3 -
-
3VS7
1
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
14
PsiBlast_PDB
86.41
76%
-101
- C3 -
-
3VS7
1
HCK_HUMAN
A:
[10-454]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
P
16
PsiBlast_PDB
85.91
76%
-99
- C3 -
-
4LUE
3
HCK_HUMAN
A:
[10-453]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
-------------
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
Y
E
E
I
-
22
Blastp_CBE
85.20
77%
-104
- C3 -
-
4LUE
4
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
---------------
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
---
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
23
Blastp_CBE
85.13
77%
-101
- C3 -
-
4LUD
3
HCK_HUMAN
B:
[10-449]
------------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
-
E
-
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
---
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
-----------------
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
-------
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
-----
530
HHSearch
77.87
59%
20
- C3 -
-
2H8H
1
SRC_HUMAN
A:
[87-531]
------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
T---
Q
----
G
-------
L
----------------------
A
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
--
46
Blastp_CBE
76.62
60%
22
- C3 -
-
2H8H
1
SRC_HUMAN
A:
[89-528]
--------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
T---
Q
----
G
-------
L
----------------------
A
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
-----
534
HHSearch
76.53
60%
11
- C3 -
-
1Y57
1
SRC_HUMAN
A:
[3-448]
-----------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
T---
Q
----
G
-------
L
----------------------
A
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
P
--
45
Blastp_CBE
76.33
60%
20
- C3 -
-
2SRC
1
SRC_HUMAN
A:
[6-445]
--------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
T---
Q
----
G
-------
L
----------------------
A
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
-----
48
Blastp_CBE
76.08
60%
24
- C3 -
-
4K11
1
SRC_HUMAN
A:
[4-443]
--------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
T---
Q
----
G
-------
L
----------------------
A
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
-----
44
Blastp_CBE
75.56
60%
25
- C3 -
-
6F3F
1
SRC_MOUSE
A:
[9-448]
--------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
T---
Q
----
G
-------
L
----------------------
A
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
-----
43
Blastp_CBE
75.46
60%
12
- C3 -
-
1Y57
1
SRC_HUMAN
A:
[6-447]
--------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
T---
Q
----
G
-------
L
----------------------
A
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
47
Blastp_CBE
74.30
60%
22
- C3 -
-
1KSW
1
SRC_HUMAN
A:
[6-445]
--------------------------------------------------------------------
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
--
N
-
N
T
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
K
P
Q
T---
Q
----
G
-------
L
----------------------
A
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
-----
49
Blastp_CBE
69.75
98%
-137
- C3 -
-
2ZVA
1
LYN_MOUSE
A:
[6-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
I
--------
K
-
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
N
---
S
T
K
-----
V
A
V
K
T
L
K
P
G
T
--
M
---
S
V
Q
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
G
K
V
L
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
----------
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
----------
51
Blastp_CBE
68.99
98%
-138
- C3 -
-
2ZV8
1
LYN_MOUSE
A:
[6-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
I
--------
K
-
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
N
---
S
T
K
-----
V
A
V
K
T
L
K
P
G
T
--
M
---
S
V
Q
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
G
K
V
L
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
---------------
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
-----------
230
Blastp_CBE
68.72
41%
18
- C3 -
-
2FO0
4
ABL1_HUMAN
A:
[37-474]
-------------------------------------------------------------
E
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
GY
N
-
H
-
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
S
G
I
N
-
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
----
K
----
P
-------
T
VYGVSP----------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
42
Blastp_CBE
68.70
100%
-143
- C3 -
-
5XY1
1
LYN_HUMAN
A:
[6-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
I
--------
K
-
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
N
---
S
T
K
-----
V
A
V
K
T
L
K
P
G
T
--
M
---
S
V
Q
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
G
K
V
L
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
---------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
----------
64
Blastp_CBE
68.49
75%
-142
- C3 -
-
3AC3
1
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
60
Blastp_CBE
68.45
75%
-142
- C3 -
-
3ACJ
2
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
50
Blastp_CBE
68.12
98%
-141
- C3 -
-
2ZV9
1
LYN_MOUSE
A:
[6-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
I
--------
K
-
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
N
---
S
T
K
-----
V
A
V
K
T
L
K
P
G
T
--
M
---
S
V
Q
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
G
K
V
L
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
-----------
540
HHSearch
68.10
41%
0
- C3 -
-
1OPK
3
ABL1_MOUSE
A:
[44-480]
-----------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
--
G
Y
N
-
H
N
G
E
W
C
E
A
Q
T
-
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
TIYG
V
----
S
-------
P
----------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
--------
539
HHSearch
67.94
41%
25
- C3 -
-
2FO0
4
ABL1_HUMAN
A:
[36-477]
------------------------------------------------------------
S
E
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
--
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
TVYG
V
----
S
-------
P
----------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
--------
83
Blastp_CBE
67.98
75%
-138
- C3 -
-
2OF2
1
LCK_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
53
Blastp_CBE
67.94
82%
-128
- C3 -
-
5ZJ6
1
HCK_HUMAN
A:
[14-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
--------
233
Blastp_CBE
67.91
40%
17
- C3 -
-
1OPL
2
ABL1_HUMAN
A:
[81-516]
---------------------------------------------------------------
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
GY
N
-
H
-
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
S
G
I
N
-
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
----
K
----
P
-------
T
VYGVSP----------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
54
Blastp_CBE
67.84
82%
-138
- C3 -
-
2HK5
1
HCK_HUMAN
A:
[2-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
----
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
------------
58
Blastp_CBE
67.81
75%
-144
- C3 -
-
3AD4
3
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
66
Blastp_CBE
67.71
75%
-140
- C3 -
-
3AC1
3
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
82
Blastp_CBE
67.67
75%
-138
- C3 -
-
2OF4
1
LCK_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
65
Blastp_CBE
67.67
75%
-138
- C3 -
-
3AC2
3
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
57
Blastp_CBE
67.65
75%
-136
- C3 -
-
3AD5
3
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
78
Blastp_CBE
67.56
75%
-137
- C3 -
-
1QPC
2
?
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
52
Blastp_CBE
67.42
82%
-131
- C3 -
-
5ZJ6
1
HCK_HUMAN
B:
[15-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
-
K
---
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
--
M
---
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
--------
41
Blastp_CBE
67.39
100%
-121
- C3 -
-
3A4O
1
LYN_HUMAN
X:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
I
--------
K
-
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
N
---
S
T
K
-----
V
A
V
K
T
L
K
P
G
T
--
M
---
S
V
Q
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
G
K
V
L
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
------------------
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
A
T
E
-------
226
Blastp_CBE
67.33
66%
-142
- C3 -
-
3DQW
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
225
Blastp_CBE
67.32
66%
-138
- C3 -
-
3DQW
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
87
Blastp_CBE
67.28
74%
-137
- C3 -
-
3BYO
1
?
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
59
Blastp_CBE
67.28
75%
-134
- C3 -
-
3ACK
2
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
84
Blastp_CBE
67.25
74%
-136
- C3 -
-
2OFU
1
LCK_HUMAN
A:
[1-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
----
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
69
Blastp_CBE
67.25
75%
-138
- C3 -
-
2ZM1
2
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
223
Blastp_CBE
67.24
66%
-137
- C3 -
-
3DQW
1
SRC_CHICK
D:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
77
Blastp_CBE
67.23
75%
-138
- C3 -
-
1QPE
1
LCK_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
229
Blastp_CBE
67.22
40%
17
- C3 -
-
1OPK
3
ABL1_MOUSE
A:
[44-477]
-----------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
GY
N
-
H
-
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
S
G
I
N
-
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
----
K
----
P
-------
T
IYGVSP----------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
63
Blastp_CBE
67.21
75%
-131
- C3 -
-
3AC4
2
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
61
Blastp_CBE
67.14
75%
-135
- C3 -
-
3AC8
1
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
85
Blastp_CBE
67.06
74%
-132
- C3 -
-
3BYM
1
LCK_HUMAN
A:
[1-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
62
Blastp_CBE
67.05
75%
-138
- C3 -
-
3AC5
2
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
56
Blastp_CBE
66.96
75%
-132
- C3 -
-
3AD6
2
LCK_HUMAN
A:
[6-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
E
-------
72
Blastp_CBE
66.94
74%
-134
- C3 -
-
3KMM
1
LCK_HUMAN
A:
[10-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
81
Blastp_CBE
66.92
74%
-137
- C3 -
-
1QPD
1
?
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
A
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
A
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
A
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
70
Blastp_CBE
66.81
75%
-136
- C3 -
-
3KXZ
1
LCK_HUMAN
A:
[16-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
68
Blastp_CBE
66.81
75%
-134
- C3 -
-
2ZM4
2
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
224
Blastp_CBE
66.79
66%
-136
- C3 -
-
3DQW
1
SRC_CHICK
C:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
73
Blastp_CBE
66.70
75%
-142
- C3 -
-
3B2W
1
LCK_HUMAN
A:
[13-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
---
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
---------
71
Blastp_CBE
66.58
75%
-139
- C3 -
-
6PDJ
2
?
A:
[2-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Q
----
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
---------
222
Blastp_CBE
66.51
67%
-136
- C3 -
-
3U4W
4
SRC_CHICK
A:
[1-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
76
Blastp_CBE
66.42
75%
-141
- C3 -
-
1QPJ
1
LCK_HUMAN
A:
[6-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
67
Blastp_CBE
66.41
75%
-136
- C3 -
-
2ZYB
1
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
136
Blastp_CBE
65.66
67%
-137
- C3 -
-
3EN4
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
140
Blastp_CBE
65.60
67%
-135
- C3 -
-
3DQX
1
SRC_CHICK
B:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
102
Blastp_CBE
65.46
67%
-140
- C3 -
-
5XP7
2
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
103
Blastp_CBE
65.37
67%
-138
- C3 -
-
5XP5
1
SRC_CHICK
B:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
79
Blastp_CBE
65.26
75%
-139
- C3 -
-
3BYU
1
LCK_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
------------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
109
Blastp_CBE
65.24
67%
-141
- C3 -
-
4YBK
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
114
Blastp_CBE
65.22
67%
-142
- C3 -
-
4O2P
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
113
Blastp_CBE
65.17
67%
-137
- C3 -
-
4U5J
1
SRC_CHICK
A:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
206
Blastp_CBE
65.07
66%
-144
- C3 -
-
6HVE
1
?
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
91
Blastp_CBE
65.02
75%
-134
- C3 -
-
3MPM
2
LCK_HUMAN
A:
[4-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-----
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
105
Blastp_CBE
64.96
67%
-142
- C3 -
-
5K9I
1
SRC_CHICK
B:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
89
Blastp_CBE
64.92
75%
-148
- C3 -
-
2OG8
1
LCK_HUMAN
A:
[2-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
----------
96
Blastp_CBE
64.88
67%
-139
- C3 -
-
4MXO
1
SRC_HUMAN
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
99
Blastp_CBE
64.82
67%
-134
- C3 -
-
2BDF
1
SRC_HUMAN
B:
[3-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
92
Blastp_CBE
64.70
70%
-132
- C3 -
-
2DQ7
1
FYN_HUMAN
X:
[1-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
V
W
-------------------
E
I
P
R
E
S
L
--------
Q
-
L
I
K
R
L
G
N
G
Q
F
G
E
V
W
M
G
T
W
--
N
-
G
---
N
T
K
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
S
--
F
L
E
-
E
A
Q
I
M
K
K
L
K
H
D
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
D
G
E
G
---
R
A
L
K
L
P
-
N
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
R
M
N
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
I
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
P
G
M
N
-
N
R
E
V
L
E
Q
V
E
R
G
Y
R
M
P
C
P
Q
D
C
P
I
S
L
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
E
D
Y
------------
55
Blastp_CBE
64.68
75%
-129
- C3 -
-
2PL0
1
LCK_HUMAN
A:
[11-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
104
Blastp_CBE
64.67
67%
-138
- C3 -
-
5XP5
1
SRC_CHICK
A:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
90
Blastp_CBE
64.64
75%
-134
- C3 -
-
4C3F
1
LCK_HUMAN
A:
[4-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
---
E
Y
---
T
--
A
R
-----
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
97
Blastp_CBE
64.54
67%
-141
- C3 -
-
4MXO
1
SRC_HUMAN
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
191
Blastp_CBE
64.51
67%
-136
- C3 -
-
3SVV
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
128
Blastp_CBE
64.52
67%
-132
- C3 -
-
3F6X
1
SRC_CHICK
D:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
134
Blastp_CBE
64.51
67%
-143
- C3 -
-
3EN5
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
125
Blastp_CBE
64.51
67%
-140
- C3 -
-
3UQF
1
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
188
Blastp_CBE
64.49
67%
-134
- C3 -
-
5SWH
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
101
Blastp_CBE
64.49
67%
-136
- C3 -
-
5XP7
2
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
232
Blastp_CBE
64.44
40%
-49
- C3 -
-
1OPL
1
ABL1_HUMAN
B:
[140-516]
------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
S
G
I
N
-
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
---------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
231
Blastp_CBE
64.42
41%
19
- C3 -
-
5MO4
2
ABL1_HUMAN
A:
[44-477]
-----------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
GY
N
-
H
-
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
S
G
I
N
-
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
----
K
----
P
-------
T
VYGVSP----------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
-------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
144
Blastp_CBE
64.42
67%
-135
- C3 -
-
2OIQ
3
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
80
Blastp_CBE
64.42
75%
-138
- C3 -
-
3BYS
1
LCK_HUMAN
A:
[6-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
T
--------
130
Blastp_CBE
64.36
67%
-137
- C3 -
-
3F6X
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
537
HHSearch
64.35
41%
18
- C3 -
-
5MO4
2
ABL1_HUMAN
A:
[44-480]
-----------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
--
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
----
T
VYGV
S
-------
P
----------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
-------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
--------
141
Blastp_CBE
64.29
67%
-139
- C3 -
-
3DQX
1
SRC_CHICK
A:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
195
Blastp_CBE
64.23
66%
-140
- C3 -
-
4MXY
1
SRC_HUMAN
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
193
Blastp_CBE
64.23
66%
-140
- C3 -
-
4MXZ
1
SRC_HUMAN
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
88
Blastp_CBE
64.23
75%
-141
- C3 -
-
2OG8
1
?
B:
[1-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
--
M
---
S
P
D
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
---------
215
Blastp_CBE
64.15
66%
-141
- C3 -
-
3F3W
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
111
Blastp_CBE
64.15
67%
-139
- C3 -
-
4YBJ
1
SRC_CHICK
A:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
190
Blastp_CBE
64.11
67%
-143
- C3 -
-
3SVV
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
-
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
196
Blastp_CBE
64.09
66%
-141
- C3 -
-
4MXY
1
SRC_HUMAN
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
189
Blastp_CBE
64.10
67%
-137
- C3 -
-
5SWH
1
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
194
Blastp_CBE
64.09
66%
-141
- C3 -
-
4MXZ
1
SRC_HUMAN
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
146
Blastp_CBE
64.04
67%
-141
- C3 -
-
4MXX
1
SRC_HUMAN
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
A
R
L
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
127
Blastp_CBE
64.04
67%
-132
- C3 -
-
3G6G
3
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-----------------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
106
Blastp_CBE
64.01
67%
-138
- C3 -
-
5K9I
1
SRC_CHICK
A:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
123
Blastp_CBE
63.98
67%
-135
- C3 -
-
3UQG
1
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
199
Blastp_CBE
63.95
67%
-132
- C3 -
-
3GEQ
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
216
Blastp_CBE
63.91
66%
-139
- C3 -
-
3F3W
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
112
Blastp_CBE
63.92
67%
-134
- C3 -
-
4U5J
1
SRC_CHICK
B:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
160
Blastp_CBE
63.91
67%
-136
- C3 -
-
3QLG
1
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
200
Blastp_CBE
63.90
67%
-130
- C3 -
-
3GEQ
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
171
Blastp_CBE
63.89
67%
-147
- C3 -
-
3G5D
2
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
-----
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
168
Blastp_CBE
63.88
67%
-140
- C3 -
-
3TZ8
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
164
Blastp_CBE
63.87
67%
-135
- C3 -
-
3OEZ
2
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
159
Blastp_CBE
63.86
67%
-143
- C3 -
-
3QLG
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
-----
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
98
Blastp_CBE
63.85
67%
-136
- C3 -
-
2BDJ
1
SRC_HUMAN
A:
[3-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
----------
156
Blastp_CBE
63.81
67%
-137
- C3 -
-
5T0P
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
107
Blastp_CBE
63.80
67%
-138
- C3 -
-
5J5S
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
108
Blastp_CBE
63.78
67%
-139
- C3 -
-
5J5S
1
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
177
Blastp_CBE
63.76
67%
-140
- C3 -
-
3F3T
2
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
166
Blastp_CBE
63.73
67%
-143
- C3 -
-
3TZ9
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
169
Blastp_CBE
63.69
67%
-142
- C3 -
-
3TZ7
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
202
Blastp_CBE
63.59
67%
-134
- C3 -
-
4MCV
1
SRC_CHICK
A:
[2-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
236
Blastp_CBE
63.58
42%
-55
- C3 -
-
4XEY
1
ABL1_HUMAN
B:
[7-382]
-------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
-
Y
L
L
S
S
G
I
N
-
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
-------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
---
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
131
Blastp_CBE
63.55
67%
-141
- C3 -
-
3F6X
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
----------
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
174
Blastp_CBE
63.53
67%
-135
- C3 -
-
3F3V
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
137
Blastp_CBE
63.52
67%
-137
- C3 -
-
3EN4
1
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
----
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
100
Blastp_CBE
63.50
67%
-133
- C3 -
-
2BDF
1
SRC_HUMAN
A:
[3-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
142
Blastp_CBE
63.46
67%
-138
- C3 -
-
3D7T
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
167
Blastp_CBE
63.44
67%
-135
- C3 -
-
3TZ8
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
192
Blastp_CBE
63.41
67%
-133
- C3 -
-
3G6H
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
155
Blastp_CBE
63.37
67%
-136
- C3 -
-
5T0P
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
187
Blastp_CBE
63.36
67%
-132
- C3 -
-
5SYS
1
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
541
HHSearch
63.35
42%
-56
- C3 -
-
4XEY
1
ABL1_HUMAN
B:
[7-386]
-------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
-----
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
---------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
---
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------
172
Blastp_CBE
63.33
67%
-146
- C3 -
-
3G5D
2
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
----------
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
186
Blastp_CBE
63.25
67%
-133
- C3 -
-
5SYS
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
129
Blastp_CBE
63.21
67%
-131
- C3 -
-
3F6X
1
SRC_CHICK
C:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
---------
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
115
Blastp_CBE
63.13
67%
-132
- C3 -
-
4O2P
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
----
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
176
Blastp_CBE
63.12
67%
-132
- C3 -
-
3F3U
2
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
201
Blastp_CBE
63.11
67%
-136
- C3 -
-
4MCV
1
SRC_CHICK
B:
[2-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
-
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
93
Blastp_CBE
63.07
67%
-135
- C3 -
-
1YOL
2
SRC_HUMAN
B:
[9-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
119
Blastp_CBE
63.03
67%
-134
- C3 -
-
4DGG
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
145
Blastp_CBE
63.01
67%
-138
- C3 -
-
4MXX
1
SRC_HUMAN
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
121
Blastp_CBE
63.00
67%
-136
- C3 -
-
4AGW
3
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
170
Blastp_CBE
62.93
67%
-136
- C3 -
-
3TZ7
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
161
Blastp_CBE
62.92
67%
-139
- C3 -
-
3QLF
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
----
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
122
Blastp_CBE
62.90
67%
-138
- C3 -
-
3UQG
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
---------
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
210
Blastp_CBE
62.89
66%
-146
- C3 -
-
5D11
2
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
---------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
163
Blastp_CBE
62.82
67%
-133
- C3 -
-
3OEZ
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
126
Blastp_CBE
62.82
67%
-135
- C3 -
-
3G6G
2
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
------------------------
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
220
Blastp_CBE
62.81
67%
-134
- C3 -
-
3U51
1
SRC_CHICK
B:
[3-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
173
Blastp_CBE
62.77
67%
-138
- C3 -
-
3F3V
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
75
Blastp_CBE
62.71
75%
-139
- C3 -
-
2OFV
1
LCK_HUMAN
A:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
--------------
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------
209
Blastp_CBE
62.66
66%
-147
- C3 -
-
5D11
2
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
----------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
157
Blastp_CBE
62.61
67%
-137
- C3 -
-
1YOM
1
SRC_HUMAN
B:
[7-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
185
Blastp_CBE
62.57
67%
-137
- C3 -
-
5TEH
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
543
HHSearch
62.56
36%
-43
- C3 -
-
6JMF
1
A:
[6-372]
-----------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
G
D
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
W
D
-----
G
L
P
R
H
F
I
I
Q
S
L
-
D
N
L
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
-----
H
----
R
----
A
-------
V
----------------------
P
K
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
D
---
N
T
L
-----
V
A
V
K
S
C
R
E
T
L
PP
D
---
L
K
A
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
-
G
---
A
R
L
R
V
K
-
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
Y
---
A
--
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
----------
208
Blastp_CBE
62.55
66%
-146
- C3 -
-
5D12
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
----------
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
118
Blastp_CBE
62.54
67%
-137
- C3 -
-
4DGG
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
-----------
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
120
Blastp_CBE
62.53
67%
-137
- C3 -
-
4AGW
3
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
221
Blastp_CBE
62.48
67%
-135
- C3 -
-
3U51
2
SRC_CHICK
A:
[3-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
110
Blastp_CBE
62.44
67%
-142
- C3 -
-
4YBJ
1
SRC_CHICK
B:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
-----
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
138
Blastp_CBE
62.33
67%
-134
- C3 -
-
3EL8
1
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
165
Blastp_CBE
62.25
67%
-133
- C3 -
-
3TZ9
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
94
Blastp_CBE
62.16
67%
-134
- C3 -
-
1YOL
1
SRC_HUMAN
A:
[7-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
124
Blastp_CBE
62.15
67%
-140
- C3 -
-
3UQF
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
------------
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
211
Blastp_CBE
62.10
66%
-151
- C3 -
-
5D10
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
---------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
183
Blastp_CBE
62.04
67%
-151
- C3 -
-
2HWO
2
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
--------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
74
Blastp_CBE
61.75
75%
-138
- C3 -
-
2OFV
1
?
B:
[7-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
----------------------
W
E
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
--
N
-
G
---
H
T
K
-----
V
A
V
K
S
L
K
Q
G
----------
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
---
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
--------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
--------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
----------
184
Blastp_CBE
61.70
67%
-134
- C3 -
-
5TEH
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
542
HHSearch
61.66
35%
-37
- C3 -
-
3BKB
9
A:
[8-374]
-----------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
G
D
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
W
D
-----
G
L
P
R
H
F
I
I
Q
S
-
L
D
N
L
Y
R
-
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
-----
H
----
R
----
A
-------
V
----------------------
P
K
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
D
---
N
T
L
-----
V
A
V
K
S
C
R
E
T
L
PP
D
---
L
K
A
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
----
A
R
L
R
V
K
-
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
Y
---
A
--
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
----------
545
HHSearch
61.56
33%
-37
- C3 -
-
4K2R
1
ZAP70_HUMAN
A:
[156-602]
-----------------------------------------------------------------------------------------------------------------------------
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
K
-
E
Q
G
T
Y
A
L
S
L
I
Y
G
-----
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
S
-------------DKPRPMP
M
DTSVYESPYSDPEELK------
D
K
K
L
F
-------------------
L
K
R
D
N
L
L
--------
I
-
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
-
M
RKK
Q
I
D
-----
V
A
I
K
V
L
K
Q
G
T
--
E
KA-
D
T
E
E
--
M
M
R
-
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
----
E
E
I
P
V
S
-
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
------------------------
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
S
------
95
Blastp_CBE
61.55
67%
-135
- C3 -
-
6ATE
1
SRC_HUMAN
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
-----------
P
E
A
--
F
---
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
178
Blastp_CBE
61.45
67%
-141
- C3 -
-
2QLQ
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
175
Blastp_CBE
61.45
67%
-131
- C3 -
-
3F3U
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
-------
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
217
Blastp_CBE
61.43
66%
-148
- C3 -
-
2QQ7
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
---------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
204
Blastp_CBE
61.36
66%
-146
- C3 -
-
6HVF
3
?
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
-----------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
421
Blastp_CBE
61.28
43%
-147
- C3 -
-
5BQ0
4
A:
[18-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
218
Blastp_CBE
61.30
66%
-145
- C3 -
-
2QQ7
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
------------------
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
117
Blastp_CBE
61.28
67%
-142
- C3 -
-
4FIC
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
---------------
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
547
HHSearch
61.12
36%
-44
- C3 -
-
4FL3
1
KSYK_HUMAN
A:
[161-632]
-----------------------------------------------------------------------------------------------------------------------------
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
S
K
T
N
G
K
F
L
I
R
A
R
D
N
-
N
G
S
Y
A
L
C
L
L
H
E
-----
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
-------------------------------------------------REALPMDTEVFESPFADPE
E
I
R
P
K
E
V
YLDRKLLT
L
-
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
KKV
V
K
T
-----
V
A
V
K
I
L
K
N
E
A
--
N
DPA
L
K
D
E
--
L
L
A
-
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
-----
H
V
K
D
K
-
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
--------------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
---------
546
HHSearch
61.16
35%
-25
- C3 -
-
4FL2
1
KSYK_HUMAN
A:
[162-633]
-----------------------------------------------------------------------------------------------------------------------------
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
S
K
T
N
G
K
F
L
I
R
A
R
D
N
-
N
G
S
Y
A
L
C
L
L
H
E
-----
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
I
G
T
-------------------QREALPMDTEVYESPYADPEEI
R
P
K
E
V
-------------------
Y
L
D
R
K
L
L
--------
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
KKV
V
K
T
-----
V
A
V
K
I
L
K
N
E
A
--
N
DPA
L
K
D
E
--
L
L
A
-
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
-----
H
V
K
D
K
-
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
---
E
N
---
Y
YK
A
Q
-
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
---------
212
Blastp_CBE
61.12
66%
-139
- C3 -
-
5D10
1
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
-------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
179
Blastp_CBE
61.11
67%
-152
- C3 -
-
2QLQ
2
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
---------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
389
Blastp_CBE
61.10
43%
-152
- C3 -
-
6DI5
2
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
205
Blastp_CBE
61.09
66%
-147
- C3 -
-
6HVE
1
?
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
-------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
384
Blastp_CBE
61.07
43%
-138
- C3 -
-
4ZLY
5
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
544
HHSearch
60.93
36%
-49
- C3 -
-
3CBL
3
A:
[8-374]
-----------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
G
D
F
L
V
R
E
S
Q
---
Q
E
Y
V
L
S
V
----------
P
R
H
F
I
I
-----
N
L
Y
R
-
L
----
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
-----
V
V
L
-----
H
----
R
----
A
-------
V
----------------------
P
K
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
D
---
N
T
L
-----
V
A
V
K
S
C
R
E
T
L
PP
D
---
L
K
A
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
-
G
---
A
R
L
R
V
K
-
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
Y
---
A
--
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
----------
203
Blastp_CBE
60.94
66%
-137
- C3 -
-
6HVF
2
?
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
-----------------
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
387
Blastp_CBE
60.93
43%
-143
- C3 -
-
6N9P
1
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
386
Blastp_CBE
60.82
43%
-139
- C3 -
-
6NFH
7
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
181
Blastp_CBE
60.79
67%
-150
- C3 -
-
2HWP
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
---
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
-----------------
F
L
Q
--
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
406
Blastp_CBE
60.74
43%
-140
- C3 -
-
5P9M
2
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
116
Blastp_CBE
60.75
67%
-140
- C3 -
-
4FIC
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
392
Blastp_CBE
60.74
43%
-143
- C3 -
-
6DI0
1
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
197
Blastp_CBE
60.71
67%
-132
- C3 -
-
4LGH
1
SRC_CHICK
B:
[3-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
-
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
424
Blastp_CBE
60.65
43%
-140
- C3 -
-
6E4F
5
A:
[25-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
410
Blastp_CBE
60.64
43%
-141
- C3 -
-
5P9I
3
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
437
Blastp_CBE
60.58
43%
-144
- C3 -
-
4OT6
1
A:
[18-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
---
A
-
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
139
Blastp_CBE
60.61
67%
-134
- C3 -
-
3EL7
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
-
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
408
Blastp_CBE
60.58
43%
-138
- C3 -
-
5P9K
1
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
214
Blastp_CBE
60.55
66%
-149
- C3 -
-
3LOK
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
---
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
--------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
411
Blastp_CBE
60.51
43%
-145
- C3 -
-
5P9H
1
A:
[15-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
385
Blastp_CBE
60.50
43%
-143
- C3 -
-
6OMU
1
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
403
Blastp_CBE
60.49
43%
-142
- C3 -
-
6NZM
1
BTK_HUMAN
A:
[16-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
366
Blastp_CBE
60.47
43%
-142
- C3 -
-
6J6M
2
?
A:
[4-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
425
Blastp_CBE
60.46
44%
-143
- C3 -
-
4Y93
1
?
A:
[182-441]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
T
G
S
K
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
428
Blastp_CBE
60.40
42%
-136
- C3 -
-
6AUA
2
A:
[1-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
A
N
--------
132
Blastp_CBE
60.39
67%
-146
- C3 -
-
3EN7
1
SRC_CHICK
A:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
------
T
R
-----
V
A
I
K
T
L
K
P
--------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
162
Blastp_CBE
60.38
67%
-144
- C3 -
-
3QLF
1
SRC_CHICK
A:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
----------------
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
431
Blastp_CBE
60.34
43%
-145
- C3 -
-
6EP9
1
A:
[20-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
---
A
-
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
182
Blastp_CBE
60.33
67%
-140
- C3 -
-
2HWO
2
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
---------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
391
Blastp_CBE
60.32
43%
-141
- C3 -
-
6DI1
1
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
135
Blastp_CBE
60.31
67%
-147
- C3 -
-
3EN5
1
SRC_CHICK
A:
[13-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
------------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
198
Blastp_CBE
60.30
67%
-144
- C3 -
-
4LGH
1
SRC_CHICK
A:
[1-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
----
T
R
-----
V
A
I
K
T
L
--------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
213
Blastp_CBE
60.26
66%
-149
- C3 -
-
3LOK
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
-----------------------
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
393
Blastp_CBE
60.25
43%
-144
- C3 -
-
5VFI
9
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
394
Blastp_CBE
60.18
43%
-138
- C3 -
-
5U9D
6
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
423
Blastp_CBE
60.12
43%
-138
- C3 -
-
4Z3V
5
A:
[18-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
383
Blastp_CBE
60.12
43%
-139
- C3 -
-
4ZLZ
5
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
451
Blastp_CBE
60.08
43%
-142
- C3 -
-
5BPY
1
BTK_HUMAN
A:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
404
Blastp_CBE
60.04
43%
-130
- C3 -
-
4YHF
2
B:
[13-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
402
Blastp_CBE
60.05
43%
-140
- C3 -
-
6NZM
2
D:
[16-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
227
Blastp_CBE
60.04
66%
-137
- C3 -
-
4LGG
1
SRC_CHICK
B:
[1-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
S
L
--------
R
-
L
E
V
K
L
G
----
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
--
M
---
S
P
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
--
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
180
Blastp_CBE
60.01
67%
-149
- C3 -
-
2HWP
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
413
Blastp_CBE
60.00
43%
-140
- C3 -
-
5P9F
6
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
228
Blastp_CBE
59.99
66%
-140
- C3 -
-
4LGG
1
SRC_CHICK
A:
[1-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
K
P
G
--------------
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
400
Blastp_CBE
59.98
43%
-139
- C3 -
-
5J87
1
BTK_HUMAN
B:
[10-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
436
Blastp_CBE
59.93
43%
-143
- C3 -
-
4OTQ
3
A:
[20-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
---
A
-
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
432
Blastp_CBE
59.92
43%
-144
- C3 -
-
4RG0
1
A:
[20-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
---
A
-
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
422
Blastp_CBE
59.91
43%
-145
- C3 -
-
3GEN
1
A:
[18-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
---
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
412
Blastp_CBE
59.90
43%
-141
- C3 -
-
5P9G
1
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
409
Blastp_CBE
59.88
43%
-144
- C3 -
-
5P9J
1
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
------
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
401
Blastp_CBE
59.87
43%
-138
- C3 -
-
5J87
1
BTK_HUMAN
A:
[12-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
375
Blastp_CBE
59.85
43%
-142
- C3 -
-
6S90
1
BTK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
390
Blastp_CBE
59.83
43%
-149
- C3 -
-
6DI3
1
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
------------------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
433
Blastp_CBE
59.70
43%
-142
- C3 -
-
4RFZ
3
A:
[20-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
---
A
-
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
273
Blastp_CBE
59.69
46%
-129
- C3 -
-
3CS9
1
ABL1_HUMAN
D:
[10-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----------
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
371
Blastp_CBE
59.68
43%
-136
- C3 -
-
5VGO
5
A:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
374
Blastp_CBE
59.62
43%
-139
- C3 -
-
6S90
1
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
438
Blastp_CBE
59.54
43%
-142
- C3 -
-
4OT5
3
A:
[20-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
---
A
-
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
207
Blastp_CBE
59.48
66%
-138
- C3 -
-
5D12
1
SRC_CHICK
B:
[11-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
------------
E
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
429
Blastp_CBE
59.35
43%
-140
- C3 -
-
6HRT
1
A:
[20-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
---
A
-
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
382
Blastp_CBE
59.28
43%
-138
- C3 -
-
3OCS
2
A:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
372
Blastp_CBE
59.28
43%
-137
- C3 -
-
5KUP
4
A:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
399
Blastp_CBE
59.26
43%
-133
- C3 -
-
5J87
1
BTK_HUMAN
C:
[12-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
419
Blastp_CBE
59.25
43%
-139
- C3 -
-
3PIX
1
A:
[9-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
455
Blastp_CBE
59.20
43%
-136
- C3 -
-
6BKW
4
A:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
396
Blastp_CBE
59.22
43%
-147
- C3 -
-
5FBN
5
D:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
-------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
435
Blastp_CBE
59.20
43%
-143
- C3 -
-
4OTR
3
A:
[20-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
---
A
-
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
449
Blastp_CBE
59.19
43%
-143
- C3 -
-
5JRS
2
BTK_HUMAN
A:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-------
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
395
Blastp_CBE
59.18
43%
-155
- C3 -
-
5FBO
2
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-----------------------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
420
Blastp_CBE
59.17
43%
-138
- C3 -
-
6AUB
1
A:
[1-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
434
Blastp_CBE
59.10
43%
-144
- C3 -
-
4RFY
3
A:
[20-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
---
A
-
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
133
Blastp_CBE
59.13
67%
-154
- C3 -
-
3EN6
1
SRC_CHICK
B:
[10-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
R
-----
V
A
I
K
T
L
---------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
----
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
---
K
Y
L
R
L
P
-
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-----------------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
P
Q
Y
Q
---
373
Blastp_CBE
59.10
43%
-139
- C3 -
-
4RX5
4
A:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
430
Blastp_CBE
59.02
43%
-139
- C3 -
-
6HRP
1
A:
[20-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
---
A
-
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
407
Blastp_CBE
58.95
43%
-153
- C3 -
-
5P9L
1
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
----
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
-------------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
405
Blastp_CBE
58.92
43%
-136
- C3 -
-
4YHF
3
BTK_HUMAN
A:
[13-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
551
Fugue
58.82
78%
-20
- C3 -
-
1QCF
1
HCK_HUMAN
A:
[173-454]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Q
K
----
P
------------
W
----------------------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
NK------
H
T
K
-----
V
A
V
K
T
M
K
P
G
S
M-----
S
V
E
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
---
S
K
Q
P
L
P
-
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
---
E
Y
TAR
E
--
G
----
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
--
A
T
E
S
Q
E
E
I
397
Blastp_CBE
58.83
43%
-148
- C3 -
-
5FBN
3
BTK_HUMAN
C:
[7-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
-----------------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
388
Blastp_CBE
58.82
43%
-156
- C3 -
-
6DI9
2
A:
[6-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
------
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
-------------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
398
Blastp_CBE
58.78
43%
-138
- C3 -
-
5J87
1
D:
[12-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
457
Blastp_CBE
58.73
43%
-136
- C3 -
-
6BKE
1
A:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
365
Blastp_CBE
58.72
43%
-153
- C3 -
-
3OCT
1
A:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
-----
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
368
Blastp_CBE
58.69
43%
-143
- C3 -
-
6O8I
1
A:
[4-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
---------------
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
454
Blastp_CBE
58.65
43%
-137
- C3 -
-
6BLN
2
A:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
445
Blastp_CBE
58.44
43%
-150
- C3 -
-
6MNY
1
?
A:
[12-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
R
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
-------------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
A
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
-------------
458
Blastp_CBE
58.25
43%
-135
* C3 *
-
6BIK
2
A:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
447
Blastp_CBE
58.17
43%
-137
- C3 -
-
5T18
1
A:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-------
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
415
Blastp_CBE
57.86
43%
-156
- C3 -
-
3PJ2
1
A:
[9-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
---------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
456
Blastp_CBE
57.70
43%
-134
- C3 -
-
6BKH
1
A:
[5-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
418
Blastp_CBE
57.58
43%
-134
- C3 -
-
3PIY
1
A:
[9-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
-----------
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
---
E
Y
---
T
--
S
S
-
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
417
Blastp_CBE
56.93
43%
-153
- C3 -
-
3PIZ
1
A:
[9-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
----------
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
452
Blastp_CBE
56.84
43%
-148
- C3 -
-
3K54
1
A:
[18-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
------------
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
--------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
367
Blastp_CBE
56.79
43%
-156
- C3 -
-
6NFI
1
A:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
----
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
---
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
-------------------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
450
Blastp_CBE
56.47
43%
-156
- C3 -
-
5BPY
1
B:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
-
G
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
--------------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
414
Blastp_CBE
56.08
43%
-153
- C3 -
-
3PJ3
1
A:
[9-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
------------
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
----------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
416
Blastp_CBE
56.02
43%
-160
- C3 -
-
3PJ1
2
A:
[9-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
----------
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
-----
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
448
Blastp_CBE
55.99
43%
-154
- C3 -
-
5JRS
1
B:
[4-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
--
S
--
M
---
S
E
D
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
-------
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
--------------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
369
Blastp_CBE
54.78
43%
-150
- C3 -
-
5XYZ
1
B:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
-------
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
-----
M
---
S
E
D
E
---
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
M
R
---
H
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
----
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
370
Blastp_CBE
54.23
43%
-163
- C3 -
-
5XYZ
1
BTK_HUMAN
A:
[3-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
-------
V
K
Y
G
K
W
--
R
-
G
---
Q
Y
D
-----
V
A
I
K
M
I
K
-----
M
---
S
E
D
-----
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
-
E
------
R
F
Q
T
Q
-
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
---
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-------------
360
Blastp_CBE
53.03
46%
-70
- C3 -
-
3SXS
1
A:
[4-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
--------
T
-
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
--
K
-
G
---
Q
Y
D
-----
V
A
V
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
F
Q
-
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
-----
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
---
Q
Y
---
V
--
S
S
-
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
--------------
550
Fugue
52.88
36%
-42
- C3 -
-
3CD3
3
A:
[1-376]
----------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
----
D
F
L
V
R
E
S
Q
E
----
Y
V
L
S
V
P
R
-----
H
F
I
I
N
L
Y
R
L
---------------
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
--------
L
H
----
R
----
A
-------
V
----------------------
P
K
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
A
D
---
N
T
L
-----
V
A
V
K
S
C
R
P
D
L
--
K
---
A
K
----
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
-
T
E
G
---
A
R
L
R
V
K
-
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
---
V
A
---
A
--
S
G
-
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--------
258
Blastp_CBE
52.86
47%
-43
- C3 -
-
1M52
1
ABL1_MOUSE
A:
[10-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
325
Blastp_CBE
52.74
48%
-40
- C3 -
-
2G2H
1
ABL1_HUMAN
B:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
326
Blastp_CBE
52.63
48%
-34
- C3 -
-
2G2H
1
ABL1_HUMAN
A:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
297
Blastp_CBE
52.61
48%
-43
- C3 -
-
3UE4
1
ABL1_HUMAN
A:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
332
Blastp_CBE
52.45
48%
-43
- C3 -
-
4TWP
1
ABL1_HUMAN
B:
[1-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
255
Blastp_CBE
52.40
47%
-44
- C3 -
-
1OPJ
2
ABL1_MOUSE
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
257
Blastp_CBE
52.38
47%
-43
- C3 -
-
1M52
3
ABL1_MOUSE
B:
[10-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
329
Blastp_CBE
52.35
48%
-40
- C3 -
-
2F4J
1
ABL1_HUMAN
A:
[7-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
241
Blastp_CBE
52.31
47%
-33
- C3 -
-
3QRI
1
ABL1_HUMAN
A:
[2-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
D
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
269
Blastp_CBE
52.19
48%
-43
- C3 -
-
2HYY
1
ABL1_HUMAN
D:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
----
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
250
Blastp_CBE
52.21
47%
-42
- C3 -
-
3MS9
2
ABL1_MOUSE
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
---
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
256
Blastp_CBE
52.19
47%
-43
- C3 -
-
1OPJ
2
ABL1_MOUSE
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
284
Blastp_CBE
52.17
48%
-40
- C3 -
-
2QOH
1
ABL1_MOUSE
A:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
--------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
260
Blastp_CBE
52.07
47%
-40
- C3 -
-
1IEP
1
ABL1_MOUSE
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
349
Blastp_CBE
52.05
45%
-54
- C3 -
-
5H2U
4
PTK6_HUMAN
B:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
Q
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
-
D
-
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
283
Blastp_CBE
52.06
48%
-44
- C3 -
-
2QOH
1
ABL1_MOUSE
B:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
-----
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
234
Blastp_CBE
52.07
57%
-40
- C3 -
-
4UEU
1
?
A:
[4-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
I
P
R
S
E
I
--------
T
-
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
--
R
-
N
Y--
N
I
E
-----
V
A
V
K
T
L
K
E
G
T
--
M
---
S
V
E
E
--
F
L
Q
-
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
G
---
H
T
V
N
A
Q
-
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-------------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----------
281
Blastp_CBE
52.06
48%
-42
- C3 -
-
3KF4
1
ABL1_MOUSE
B:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
---
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
262
Blastp_CBE
52.05
47%
-45
- C3 -
-
1FPU
1
ABL1_MOUSE
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
353
Blastp_CBE
52.04
45%
-52
- C3 -
-
5D7V
3
PTK6_HUMAN
C:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
Q
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
-
D
-
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
314
Blastp_CBE
52.01
47%
-39
- C3 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
307
Blastp_CBE
52.01
48%
-46
- C3 -
-
6NPE
2
ABL1_HUMAN
A:
[19-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
296
Blastp_CBE
52.00
48%
-38
- C3 -
-
3UE4
1
ABL1_HUMAN
B:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
309
Blastp_CBE
51.91
48%
-46
- C3 -
-
3PYY
1
ABL1_HUMAN
A:
[19-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
---------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
336
Blastp_CBE
51.93
48%
-42
- C3 -
-
2Z60
1
ABL1_MOUSE
A:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
--------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
330
Blastp_CBE
51.89
48%
-41
- C3 -
-
3OY3
1
ABL1_MOUSE
B:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
321
Blastp_CBE
51.89
48%
-48
- C3 -
-
3DK3
1
ABL1_MOUSE
B:
[4-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
------
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
F
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
244
Blastp_CBE
51.91
47%
-46
- C3 -
-
6HD4
2
ABL1_MOUSE
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
-----
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
312
Blastp_CBE
51.89
48%
-44
- C3 -
-
6BL8
1
ABL1_HUMAN
B:
[1-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
---
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
F
---
T
--
A
H
--
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
278
Blastp_CBE
51.87
46%
-37
- C3 -
-
2HZI
1
ABL1_HUMAN
A:
[10-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
303
Blastp_CBE
51.86
48%
-43
- C3 -
-
6NPV
2
ABL1_HUMAN
A:
[19-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
292
Blastp_CBE
51.85
48%
-41
- C3 -
-
4WA9
1
ABL1_HUMAN
B:
[7-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
322
Blastp_CBE
51.81
48%
-45
- C3 -
-
3DK3
1
ABL1_MOUSE
A:
[4-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
---------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
F
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
270
Blastp_CBE
51.78
48%
-41
- C3 -
-
2HYY
1
ABL1_HUMAN
C:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
-
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
------
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
243
Blastp_CBE
51.71
47%
-41
- C3 -
-
6HD6
2
ABL1_MOUSE
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
----
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
253
Blastp_CBE
51.69
47%
-40
- C3 -
-
3K5V
2
ABL1_MOUSE
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
---
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
350
Blastp_CBE
51.70
45%
-51
- C3 -
-
5H2U
4
PTK6_HUMAN
A:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
Q
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
-
D
-
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
245
Blastp_CBE
51.69
47%
-41
- C3 -
-
6HD4
3
ABL1_MOUSE
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
---
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
286
Blastp_CBE
51.68
48%
-33
- C3 -
-
4ZOG
5
ABL1_HUMAN
A:
[5-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
239
Blastp_CBE
51.62
47%
-36
- C3 -
-
3QRK
1
ABL1_HUMAN
A:
[5-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------------
282
Blastp_CBE
51.59
48%
-44
- C3 -
-
3KF4
1
ABL1_MOUSE
A:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
328
Blastp_CBE
51.60
48%
-33
- C3 -
-
2G2F
1
ABL1_HUMAN
A:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
271
Blastp_CBE
51.59
48%
-41
- C3 -
-
2HYY
1
ABL1_HUMAN
B:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
-
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
298
Blastp_CBE
51.58
48%
-31
- C3 -
-
2G1T
1
ABL1_HUMAN
D:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
331
Blastp_CBE
51.55
48%
-42
- C3 -
-
3OY3
1
ABL1_MOUSE
A:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
313
Blastp_CBE
51.50
48%
-36
- C3 -
-
6BL8
1
ABL1_HUMAN
A:
[1-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
F
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
272
Blastp_CBE
51.50
48%
-41
- C3 -
-
2HYY
1
ABL1_HUMAN
A:
[8-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
-
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
351
Blastp_CBE
51.43
45%
-56
- C3 -
-
5DA3
3
PTK6_HUMAN
A:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
-
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
-
D
-
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
279
Blastp_CBE
51.44
48%
-41
- C3 -
-
3KFA
1
ABL1_MOUSE
B:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
280
Blastp_CBE
51.43
48%
-39
- C3 -
-
3KFA
1
ABL1_MOUSE
A:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
352
Blastp_CBE
51.41
45%
-48
- C3 -
-
5D7V
3
PTK6_HUMAN
D:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
Q
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
-
D
-
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
334
Blastp_CBE
51.34
48%
-44
- C3 -
-
3IK3
1
ABL1_MOUSE
B:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
311
Blastp_CBE
51.34
48%
-44
- C3 -
-
2HIW
1
ABL1_HUMAN
A:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
277
Blastp_CBE
51.31
46%
-47
- C3 -
-
2HZI
1
ABL1_HUMAN
B:
[10-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
------
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
362
Blastp_CBE
51.30
46%
-71
- C3 -
-
3SXR
1
BMX_HUMAN
A:
[4-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
--------
T
-
L
L
K
E
L
G
S
----
V
V
K
L
G
K
W
--
K
-
G
---
Q
Y
D
-----
V
A
V
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
F
Q
-
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
-----
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
---
Q
Y
---
V
--
S
S
-
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
--------------
324
Blastp_CBE
51.29
48%
-38
- C3 -
-
2G2I
1
ABL1_HUMAN
A:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
461
Blastp_CBE
51.24
43%
-62
- C3 -
-
4M13
1
A:
[5-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
---
T
--
S
S
-
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
299
Blastp_CBE
51.26
48%
-29
- C3 -
-
2G1T
1
ABL1_HUMAN
C:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
252
Blastp_CBE
51.25
47%
-44
- C3 -
-
3K5V
2
ABL1_MOUSE
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
-----
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
254
Blastp_CBE
51.24
47%
-42
- C3 -
-
2HZN
1
ABL1_MOUSE
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
--
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
300
Blastp_CBE
51.23
48%
-30
- C3 -
-
2G1T
1
ABL1_HUMAN
B:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
305
Blastp_CBE
51.20
48%
-40
- C3 -
-
6NPU
2
ABL1_HUMAN
A:
[19-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
240
Blastp_CBE
51.18
47%
-41
- C3 -
-
3QRI
1
ABL1_HUMAN
B:
[10-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
----------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
467
Blastp_CBE
51.12
43%
-67
- C3 -
-
4HCT
1
A:
[5-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
---
T
--
S
S
-
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
259
Blastp_CBE
51.16
47%
-43
- C3 -
-
1IEP
1
ABL1_MOUSE
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
288
Blastp_CBE
51.13
48%
-38
- C3 -
-
2HZ0
1
ABL1_HUMAN
A:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
363
Blastp_CBE
51.12
45%
-63
- C3 -
-
6CZ4
1
PTK6_HUMAN
A:
[4-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
-------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
Q
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
------
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
C
F
K
A
L
R
E
R
L
---------------
347
Blastp_CBE
51.09
45%
-53
- C3 -
-
5H2U
4
PTK6_HUMAN
D:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
Q
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
-
D
-
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
267
Blastp_CBE
51.07
48%
-37
- C3 -
-
2HZ4
1
ABL1_HUMAN
B:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
361
Blastp_CBE
51.00
46%
-71
- C3 -
-
3SXR
1
B:
[4-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
--------
T
-
L
L
K
E
L
------
V
V
K
L
G
K
W
--
K
-
G
---
Q
Y
D
-----
V
A
V
K
M
I
K
E
G
S
--
M
---
S
E
D
E
--
F
F
Q
-
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
-----
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
---
Q
Y
---
V
--
S
S
-
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
--------------
355
Blastp_CBE
50.98
45%
-49
- C3 -
-
5D7V
3
PTK6_HUMAN
A:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
Q
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
-
D
-
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
333
Blastp_CBE
50.96
48%
-37
- C3 -
-
4TWP
1
ABL1_HUMAN
A:
[1-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
----------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
316
Blastp_CBE
50.95
50%
-48
- C3 -
-
3HMI
1
A:
[25-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
E
E
V
T
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----------------------
348
Blastp_CBE
50.90
45%
-52
- C3 -
-
5H2U
4
PTK6_HUMAN
C:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
Q
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
-
D
-
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
364
Blastp_CBE
50.91
45%
-51
- C3 -
-
6CZ3
1
PTK6_HUMAN
A:
[3-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
-------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
Q
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
-
D
-
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
C
F
K
A
L
R
E
R
L
---------------
235
Blastp_CBE
50.90
57%
-42
- C3 -
-
4CSV
1
?
A:
[5-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
I
P
R
S
E
I
--------
T
-
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
--
R
-
N
Y--
N
I
E
-----
V
A
V
K
T
L
K
E
G
T
--
M
---
S
V
E
E
--
F
L
Q
-
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
-------
V
N
A
Q
-
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
----------
354
Blastp_CBE
50.84
45%
-52
- C3 -
-
5D7V
3
PTK6_HUMAN
B:
[2-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
--------
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
--
K
-
D
---
R
V
Q
-----
V
A
I
K
V
I
S
R
D
N
--
L
---
L
H
Q
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
---
K
V
L
P
V
S
-
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
---
V
Y
---
L
--
S
H
-
D
-
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
F
------------
464
Blastp_CBE
50.87
43%
-64
- C3 -
-
4M0Y
2
A:
[5-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
---
T
--
S
S
-
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
318
Blastp_CBE
50.84
50%
-51
- C3 -
-
2XYN
4
C:
[27-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
--
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
E
E
V
T
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----------------------
264
Blastp_CBE
50.84
47%
-45
- C3 -
-
2E2B
1
ABL1_HUMAN
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
------
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
-------
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
285
Blastp_CBE
50.81
48%
-37
- C3 -
-
4ZOG
2
ABL1_HUMAN
B:
[6-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
-----
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
319
Blastp_CBE
50.74
50%
-51
- C3 -
-
2XYN
4
ABL2_HUMAN
B:
[26-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
--
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
E
E
V
T
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----------------------
246
Blastp_CBE
50.74
47%
-42
- C3 -
-
3MSS
2
ABL1_MOUSE
D:
[3-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
-----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
315
Blastp_CBE
50.72
47%
-41
- C3 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
----------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------------
335
Blastp_CBE
50.71
48%
-43
- C3 -
-
3IK3
1
ABL1_MOUSE
A:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
248
Blastp_CBE
50.69
47%
-42
- C3 -
-
3MSS
2
ABL1_MOUSE
B:
[3-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
-----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
237
Blastp_CBE
50.61
42%
-40
- C3 -
-
4XEY
1
ABL1_HUMAN
A:
[116-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
460
Blastp_CBE
50.60
43%
-64
- C3 -
-
4M14
2
A:
[5-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
---
T
--
S
S
-
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
261
Blastp_CBE
50.56
47%
-43
- C3 -
-
1FPU
1
ABL1_MOUSE
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--------
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
317
Blastp_CBE
50.53
50%
-53
- C3 -
-
3GVU
2
A:
[25-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
E
E
V
T
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
---
G
D
---
T
Y
---
T
-------
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----------------------
446
Blastp_CBE
50.43
43%
-64
- C3 -
-
3T9T
3
A:
[3-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
---
T
--
S
S
-
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
242
Blastp_CBE
50.47
47%
-44
- C3 -
-
6HD6
1
ABL1_MOUSE
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
-----
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
263
Blastp_CBE
50.44
47%
-42
- C3 -
-
2E2B
1
ABL1_HUMAN
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
----------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
301
Blastp_CBE
50.43
48%
-30
- C3 -
-
2G1T
1
ABL1_HUMAN
A:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
295
Blastp_CBE
50.38
48%
-46
- C3 -
-
4YC8
3
ABL1_HUMAN
A:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
------
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
310
Blastp_CBE
50.37
48%
-35
- C3 -
-
2HIW
1
ABL1_HUMAN
B:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
462
Blastp_CBE
50.28
43%
-63
- C3 -
-
4M12
1
A:
[5-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
---
T
--
S
S
-
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
320
Blastp_CBE
50.27
50%
-49
- C3 -
-
2XYN
2
ABL2_HUMAN
A:
[26-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
--
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
E
E
V
T
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----------------------
463
Blastp_CBE
50.29
43%
-64
- C3 -
-
4M0Z
2
A:
[5-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
---
T
--
S
S
-
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
276
Blastp_CBE
50.28
46%
-37
- C3 -
-
3CS9
1
ABL1_HUMAN
A:
[10-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
---------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
289
Blastp_CBE
50.27
48%
-44
- C3 -
-
5HU9
13
ABL1_HUMAN
A:
[8-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
294
Blastp_CBE
50.24
48%
-40
- C3 -
-
4YC8
3
ABL1_HUMAN
B:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
459
Blastp_CBE
50.22
43%
-60
- C3 -
-
4M15
2
A:
[5-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
---
T
--
S
S
-
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
265
Blastp_CBE
50.15
48%
-49
- C3 -
-
3OXZ
1
ABL1_MOUSE
A:
[6-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
-----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------------------
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
327
Blastp_CBE
50.12
48%
-37
- C3 -
-
2G2F
1
ABL1_HUMAN
B:
[9-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
323
Blastp_CBE
49.87
48%
-36
- C3 -
-
2G2I
1
ABL1_HUMAN
B:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
P
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
247
Blastp_CBE
49.83
47%
-41
- C3 -
-
3MSS
2
ABL1_MOUSE
C:
[3-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
-----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
251
Blastp_CBE
49.78
47%
-37
- C3 -
-
3MS9
2
ABL1_MOUSE
A:
[3-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
-----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
249
Blastp_CBE
49.58
47%
-40
- C3 -
-
3MSS
2
ABL1_MOUSE
A:
[3-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
-----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
306
Blastp_CBE
49.39
48%
-47
- C3 -
-
6NPE
3
ABL1_HUMAN
B:
[19-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
-----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
274
Blastp_CBE
49.34
46%
-43
- C3 -
-
3CS9
1
ABL1_HUMAN
C:
[9-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
----------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
291
Blastp_CBE
49.09
50%
-47
- C3 -
-
4XLI
1
ABL2_MOUSE
A:
[1-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
---------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
---
E
E
V
T
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----------------------
304
Blastp_CBE
48.92
48%
-49
- C3 -
-
6NPU
5
ABL1_HUMAN
B:
[19-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
-----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
------------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
275
Blastp_CBE
48.89
46%
-44
- C3 -
-
3CS9
1
ABL1_HUMAN
B:
[10-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
---
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
302
Blastp_CBE
48.63
48%
-45
- C3 -
-
6NPV
5
ABL1_HUMAN
B:
[19-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
-----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
------------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
472
Blastp_CBE
48.56
44%
-64
- C3 -
-
3MJ2
1
A:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
---
Q
Y
---
T
--
S
S
-
T
G
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
287
Blastp_CBE
48.17
48%
-53
- C3 -
-
2HZ0
1
ABL1_HUMAN
B:
[4-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
------
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
308
Blastp_CBE
48.14
48%
-46
- C3 -
-
3PYY
3
ABL1_HUMAN
B:
[19-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
-----------
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
------------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
290
Blastp_CBE
48.05
50%
-44
- C3 -
-
4XLI
1
B:
[1-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
----
G
E
V
Y
V
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
---
E
E
V
T
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----------------------
524
Blastp_CBE
47.65
42%
-36
- C3 -
-
6HEV
1
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------
V
----------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------KKEVP
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
489
Blastp_CBE
47.48
44%
-66
- C3 -
-
1SM2
1
ITK_HUMAN
A:
[7-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
508
Blastp_CBE
47.34
43%
-72
- C3 -
-
4L7S
1
B:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
493
Blastp_CBE
47.00
44%
-71
- C3 -
-
3QGW
1
ITK_HUMAN
A:
[29-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
K
E
G
S
--
M
---
S
E
D
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
523
Blastp_CBE
46.98
42%
-29
- C3 -
-
6HEW
1
A:
[11-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------KKEVP
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
528
Blastp_CBE
46.86
42%
-25
- C3 -
-
6FNH
5
C:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------
V
----------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
-----
G
KKEVP
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
529
Blastp_CBE
46.83
42%
-8
- C3 -
-
6FNH
6
EPHA2_HUMAN
B:
[8-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
---
S
--KEVP-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
PEA--------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
486
Blastp_CBE
46.79
44%
-62
- C3 -
-
1SNU
1
B:
[7-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
488
Blastp_CBE
46.66
44%
-68
- C3 -
-
1SM2
1
B:
[7-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
----------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
525
Blastp_CBE
46.51
42%
-25
- C3 -
-
6HEU
1
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------
V
----------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
------KEVP-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
518
Blastp_CBE
46.51
42%
-28
- C3 -
-
6Q7D
1
?
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------
V
----------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
------KEVP-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
522
Blastp_CBE
46.50
42%
-34
- C3 -
-
6HEX
1
A:
[11-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------KKEVP
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
510
Blastp_CBE
46.41
43%
-73
- C3 -
-
4KIO
3
D:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
----------
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
--------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
487
Blastp_CBE
46.39
44%
-64
- C3 -
-
1SNU
1
ITK_HUMAN
A:
[7-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
469
Blastp_CBE
46.30
44%
-66
- C3 -
-
4PQN
2
A:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
492
Blastp_CBE
46.27
44%
-63
- C3 -
-
3QGW
1
B:
[29-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
K
E
G
S
--
M
---
S
E
D
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
527
Blastp_CBE
46.26
42%
-33
- C3 -
-
6HES
2
A:
[5-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
A
-------
V
----------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------KKEVP
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
479
Blastp_CBE
46.22
44%
-80
- C3 -
-
3V8T
1
ITK_HUMAN
A:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
R
E
G
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
--------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
520
Blastp_CBE
45.92
42%
-22
- C3 -
-
6Q7B
1
?
A:
[5-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
A
-------
V
----------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
------KEVP-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
293
Blastp_CBE
45.83
48%
-30
- C3 -
-
4WA9
1
ABL1_HUMAN
A:
[10-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
----------------------------
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
---
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
---
T
Y
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
340
Blastp_CBE
45.63
47%
-18
- C3 -
-
2GQG
2
ABL1_HUMAN
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
---
D
T
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
519
Blastp_CBE
45.43
42%
-25
- C3 -
-
6Q7C
1
?
A:
[5-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
A
-------
V
----------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
--
F
G
E
V
Y
K
G
M
L
--
K
-
T
------KEVP-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
470
Blastp_CBE
45.31
44%
-69
- C3 -
-
4MF1
1
B:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
---
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
515
Blastp_CBE
45.26
42%
-21
- C3 -
-
6Q7G
1
?
A:
[7-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
------KEVP-
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
339
Blastp_CBE
44.95
47%
-22
- C3 -
-
2GQG
2
ABL1_HUMAN
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
----
S
----
P
------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
---
D
T
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
343
Blastp_CBE
44.53
47%
-25
- C3 -
-
2V7A
1
ABL1_HUMAN
B:
[8-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
---
D
T
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
471
Blastp_CBE
44.47
44%
-64
- C3 -
-
4MF1
1
ITK_HUMAN
A:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
---
A
--
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
--------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
517
Blastp_CBE
44.22
42%
-5
- C3 -
-
6Q7E
1
?
A:
[7-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
------EVP--
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
521
Blastp_CBE
44.17
42%
-1
- C3 -
-
6HEY
1
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------
V
----------------------
L
K
F
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
---
S
--EVP--
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
526
Blastp_CBE
44.16
42%
-2
- C3 -
-
6HET
1
A:
[11-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
------EVP--
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
344
Blastp_CBE
44.02
47%
-26
- C3 -
-
2V7A
1
ABL1_HUMAN
A:
[7-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
--
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
N
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
---
D
T
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
342
Blastp_CBE
44.02
47%
-27
- C3 -
-
3DK7
1
ABL1_MOUSE
A:
[4-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
K
---------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
---
D
T
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
341
Blastp_CBE
43.90
47%
-31
- C3 -
-
3DK7
1
ABL1_MOUSE
B:
[4-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
------
M
---
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
---
D
T
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
516
Blastp_CBE
43.52
42%
2
- C3 -
-
6Q7F
1
?
A:
[11-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
-------------------
E
I
H
P
S
C
V
--------
T
-
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
------EVP--
V
A
I
K
T
L
K
A
G
Y
--
T
---
E
K
Q
R
VD
F
L
G
-
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
---
E
F
S
V
L
--
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------
497
Blastp_CBE
43.10
43%
-60
- C3 -
-
4QD6
2
ITK_HUMAN
A:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
----------
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
496
Blastp_CBE
43.01
43%
-62
- C3 -
-
4QD6
2
B:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
-----------
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
338
Blastp_CBE
42.89
48%
-24
- C3 -
-
3DK6
1
ABL1_MOUSE
A:
[4-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
----------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
---
D
T
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
503
Blastp_CBE
42.78
43%
-64
- C3 -
-
4PPA
2
ITK_HUMAN
A:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
------------
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
337
Blastp_CBE
41.99
48%
-26
- C3 -
-
3DK6
1
ABL1_MOUSE
B:
[5-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
-------
E
V
Y
E
G
V
W
--
K
-
K
Y--
S
L
T
-----
V
A
V
K
T
L
----------
E
V
E
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
E
V
S
A
V
-
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
---
D
T
---
T
--
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------
502
Blastp_CBE
41.57
43%
-59
- C3 -
-
4PPA
2
B:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
------------
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
500
Blastp_CBE
41.50
43%
-58
- C3 -
-
4PPB
2
B:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
------------
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
507
Blastp_CBE
41.07
43%
-62
- C3 -
-
4MF0
2
ITK_HUMAN
A:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
------
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
501
Blastp_CBE
40.87
43%
-58
- C3 -
-
4PPB
2
ITK_HUMAN
A:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
------------
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
499
Blastp_CBE
40.84
43%
-54
- C3 -
-
4PPC
2
ITK_HUMAN
A:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
-----------------
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
506
Blastp_CBE
40.09
43%
-54
- C3 -
-
4MF0
2
B:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
------
M
---
S
E
E
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
498
Blastp_CBE
40.06
43%
-51
- C3 -
-
4PPC
2
B:
[9-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
-
N
---
K
D
K
-----
V
A
I
K
T
I
-----------------
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
LFA
A
E
T
L
L
G
-
M
C
L
D
----
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------