@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M3K4_HUMAN: (2021-11-23 )
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
Atome Classification :
(83 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340.......1350......1360---......1370.-.-..-..1380......-.---1390..-....1400......1410......1420-.....-.----.-1430.---.-----.------.--.-....------1440......1450......1460......1470.--......1480-......1490...--...1500--.......1510..--....1520......1530......1540..----..--.--.1550-.......----------------1560.-.---..-.------.--.------------.1570......----------..1580......1590--.........1600.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MREAAAALVPPPA
F
A
VTP
A
A
AMEEPPPPPPPPPPPPEPETESE
P
E
C
C
L
A
ARQEGTLGDSACKSP
E
S
D
L
E
DFSDETNTENLYGTSPPS
T
P
R
Q
M
K
R
M
S
T
K
H
QRNNVGRPA
S
R
S
N
L
K
E
K
MNAPNQPPHKDTG
K
T
V
E
N
V
E
E
Y
S
Y
K
Q
E
K
K
I
R
A
A
L
RT
T
E
R
D
R
KKN
V
Q
C
S
F
M
L
D
SVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDC
P
A
D
R
L
K
F
F
E
T
L
R
L
L
L
K
L
T
SVS
K
K
K
D
R
E
QRGQENT
S
G
F
W
LNRSN
E
L
I
W
L
E
L
Q
AWHAGRTINDQ
D
F
F
L
Y
T
A
R
Q
A
I
P
D
I
I
N
E
I
L
T
F
K
VDYG
S
F
A
F
V
RDRAGFNGTSVE
G
Q
C
KATPG
T
K
I
V
G
YS
T
H
H
E
H
L
Q
R
QRV
S
F
E
Q
V
K
R
I
M
E
L
L
E
Y
I
E
A
L
Y
P
S
L
Q
A
L
Q
K
D
Y
E
K
Y
A
A
K
D
F
Q
D
R
V
Q
A
L
C
L
W
L
N
I
T
K
D
L
N
Q
K
L
R
I
M
G
T
VLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTE
G
E
L
K
E
L
ESSTDE
S
E
E
EQISDPRV
P
E
I
RQPIDNSFDIQ
S
R
D
C
I
S
K
K
L
E
R
L
ESEDDSLGWGAPDWSTEAGF
S
R
H
C
L
T
S
I
Y
R
P
F
V
D
K
A
L
K
Q
M
G
L
R
K
L
I
L
R
L
H
K
LMDGSL
Q
R
A
R
I
A
L
V
KNDRPVEFSEFPDPMWGSD
Y
V
Q
L
SRTPPSSEEKCSAV
S
W
E
E
L
KAMDLPSFE
P
A
F
L
V
L
C
R
V
L
L
N
V
I
H
E
C
L
K
L
R
L
EQRPAGE
P
S
L
L
S
I
K
Q
L
V
R
E
C
K
E
V
L
KG
G
L
L
M
K
Q
Y
Y
Q
F
M
L
Q
E
V
L
E
D
L
EKPDCN
I
D
A
F
E
E
D
L
H
K
M
L
M
V
Y
F
D
Y
M
R
S
W
I
Q
M
L
Q
Q
L
P
Q
A
S
H
S
L
K
N
L
L
E
E
EW
N
F
T
K
E
I
T
H
Y
I
RGGEAQ
A
G
K
L
F
C
D
I
A
G
M
L
L
K
ST
G
S
F
L
E
F
G
L
Q
E
S
C
A
E
F
W
TSADDSS
A
S
D
E
I
R
R
S
V
I
E
I
S
R
A
L
K
E
L
F
H
E
A
R
E
R
A
S
K
A
L
G
F
A
K
M
L
R
K
D
L
E
I
A
A
E
FRLSA
P
V
R
D
L
L
D
V
LKSK
Q
Y
V
K
V
QIPGLE
N
L
Q
M
FVPD
T
L
A
E
E
K
S
I
I
L
Q
L
L
N
A
AAGKDCSKDSD
D
V
L
I
D
A
Y
L
L
L
TKHGDRARDSEDSWGTWEAQ
P
V
K
V
V
PQ
V
E
T
V
D
T
L
R
S
M
Q
V
D
N
L
L
L
V
V
M
QSAHL
T
I
Q
R
K
A
F
Q
Q
S
I
E
G
L
M
T
L
C
Q
EQTSSQ
P
V
I
A
K
A
L
Q
Q
L
K
N
D
A
L
E
L
C
N
R
I
S
N
A
I
D
R
V
D
H
M
F
TSEFDAEVDESES
V
T
L
Q
Q
Y
Y
R
E
A
M
I
Q
GYNF
G
F
E
Y
H
K
E
V
V
R
L
M
S
G
E
F
R
Q
K
I
G
D
K
Y
I
S
F
A
R
K
W
M
N
Y
V
L
T
KCESGRGTRPRWATQ
G
F
D
F
L
Q
A
I
E
P
A
F
I
S
ALPE
D
D
F
L
S
L
Q
A
L
M
N
E
C
I
G
H
V
IGKPHSPV
T
G
L
Y
L
A
I
HRNSPRPMKVPRCHSDPPN
P
H
L
I
I
PTPEGFSTRSMPS
D
A
RSHGS
P
A
A
A
A
A
A
A
A
A
A
V
AASRPSPSGGDSVL
P
K
S
I
S
SAHDTRGSSVPEN
D
R
L
A
S
I
A
A
E
L
Q
F
R
S
LSRHSSPTEERDEPAYPRGDSSGST
R
R
S
W
E
L
R
T
L
I
SQSKD
T
A
SKLG
P
I
E
A
I
Q
K
S
V
R
L
F
E
E
K
R
Y
R
E
M
R
R
K
N
I
I
G
QVCDTPKS
Y
D
N
V
M
H
VG
L
R
K
V
T
F
K
-WQRGNKIGEGQY
G
K
V
Y
T
C
I
SV---DT
G
E
L
M
A
M
K
E
I-R-FQ-PNDH
K
-
T
I
K
E
T
A
-
D
---
E
L
K
I
F
E-GIKHP
N
L
V
R
Y
FG
V
E
L
H
R
E
E
M
Y
I
F
M
E
YC--DEG
T
L
-
E
----
E
-
V
---
S
---R-----L------
G
--
L
-
Q
E
H
V
------
I
R
L
YSK
Q
I
T
I
A
I
N
V
L
H
EHGI
V
H
R
DIKG
A
N
I
F
L
-TS--SG
L
I
K
LGDF
G
-
C
S
V
K
LKNNAQTMP--GEVN-ST--LG
T
A
A
Y
M
A
P
E
V
I
T
--RAKGEGHGR
A
A
D
I
W
S
L
G
C
V
V
I
E
MVTGKR
P
W
----
H
E
--Y--EH
N
F
--
Q
I
M
Y
K
VG----------------MG--H-K---PP-I------P--E------------RL--SPE
G
K
D
F
----------
L
S
H
C
L
ESDPK
M
R
W
-----
T
A
S
Q
L
L
D
H
S
F
V
K
VCTDEE
323
Fugue
82.51
17%
-4
- C3 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-533]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
----
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
-
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
--
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
-------
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
---
A
T
G
K
L
Y
A
C
K
K
L
N
K
-
K
R
-
L
K
K
R
K
-
G
Y
Q
G
A
M
-
V
---
E
K
K
I
L
A
-
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
--
N
G
G
D
I
-
R
----
Y
-
H
---
I
---
Y
-----
N
VDEDNP
G
--
F
-
Q
E
P
R
------
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
-
D
D
--
D
G
N
V
R
I
S
D
L
G
-
L
A
V
E
L
K
A
G
Q
T
K
T
K
--
G
Y
A
-------
G
T
P
G
F
M
A
P
E
L
L
-----
L
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
----
R
A
--
R
GE
K
V
E
N
--
K
E
L
K
Q
R
V
----------------
L
E
--
Q
-
A
---
V
T
-
Y
------
P
--
D
------------
K
F
--
S
P
A
S
K
D
F
----------
C
E
A
L
L
Q
K
D
P
E
K
R
L
GFRDG
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
319
Fugue
80.57
19%
-19
- C3 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
----
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
F
R
-
Q
Y
R
--
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
---
A
T
G
K
M
Y
A
C
K
K
L
-
E
-
K
K
-
R
I
K
K
R
K
G
E
A
M
A
L
-
N
---
E
K
Q
I
L
E
-
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
--
N
G
G
D
L
-
K
----
F
-
H
---
I
---
Y
HMGQ-
A
------
G
--
F
-
P
E
A
R
------
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
-
D
D
--
H
G
H
I
R
I
S
D
L
G
-
L
A
V
H
V
P
E
G
Q
T
-------
I
K
-
G
R
--
V
G
T
V
G
Y
M
A
P
E
V
V
-----
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
----
Q
Q
--
R
--
K
K
K
I
KR
E
E
V
E
R
L
V
----------------
K
E
--
V
-
P
---
E
E
-
Y
------
S
--
E
------------
R
F
--
S
P
Q
A
R
S
L
----------
C
S
Q
L
L
C
K
D
P
A
E
R
L
GCRGG
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
49
Blastp_CBE
70.95
36%
-37
- C3 -
-
6FD3
3
PAK3_HUMAN
A:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
L
D
I
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
-
Q
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
D
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
--
E
Q
S
K
R
S
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
V
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
R
L
--
S
A
V
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
D
R
R
G
-----
S
A
K
E
L
L
Q
H
P
F
L
K
L
-----
121
Blastp_CBE
70.43
35%
-50
- C3 -
-
4LGD
1
STK3_HUMAN
B:
[33-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
---
E
S
G
Q
V
V
A
I
K
Q
V
-
P
-
V
E
-
S
D
L
Q
E
-
I
I
K
E
--------
I
S
I
M
Q
-
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
--
G
A
G
S
V
-
S
----
D
-
I
---
I
---
R
-----
L
RNK---
T
--
L
-
I
E
D
E
------
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
-
N
T
--
E
G
H
A
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
---
T
M
---
A
K
R
N
-
T
V
--
I
G
T
P
F
W
M
A
P
E
V
I
Q
--
E
I
---
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
----
A
D
--
I
---
H
P
M
--
R
A
I
F
M
I
P
----------------
T
N
--
P
-
P
---
P
T
-
F
RK----
P
--
E
------------
L
W
--
S
D
D
F
T
D
F
----------
V
K
K
C
L
V
K
N
P
E
Q
R
A
-----
T
A
T
Q
L
L
Q
H
P
F
I
K
------
66
Blastp_CBE
70.38
36%
-46
- C3 -
-
4ZJI
1
PAK1_HUMAN
A:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
------
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
-------
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
61
Blastp_CBE
69.22
36%
-49
- C3 -
-
4ZJJ
1
PAK1_HUMAN
B:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
------
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
--------
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
65
Blastp_CBE
69.01
36%
-48
- C3 -
-
4ZJI
1
PAK1_HUMAN
B:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
-------
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
-------
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
331
Fugue
68.86
24%
-32
- C3 -
-
1KOB
1
?
A:
[23-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
-
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
---
A
T
G
R
V
F
V
A
K
F
I
-
N
----
T
P
Y
P
L
-
D
K
Y
T
V
K
-
N
---
E
I
S
I
M
N
-
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
--
S
G
G
E
L
-
F
----
D
-
R
IAA
E
---
D
-----
Y
------
K
--
M
-
S
E
A
E
------
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
-
E
T
KK
A
S
S
V
K
I
I
D
F
G
-
L
A
T
K
L
N
P
D
-------
E
I
V
K
-
V
T
--
T
A
T
A
E
F
A
A
P
E
I
V
-----
D
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
----
A
G
ED
D
--
L
E
T
L
--
Q
N
V
K
R
C
D
----------------
W
E
--
F
-
D
---
E
D
-
A
------
F
--
S
------------
S
V
--
S
P
E
A
K
D
F
----------
I
K
N
L
L
Q
K
E
P
R
K
R
L
-----
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
133
Blastp_CBE
68.31
32%
-37
- C3 -
-
6BDN
1
TAOK3_HUMAN
A:
[32-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
I
G
H
G
S
F
G
A
V
Y
F
A
T
N
A
---
H
T
S
E
V
V
A
I
K
K
M
-
S
-
Y
S
G
K
Q
T
H
E
-
K
W
Q
D
I
L
-
K
---
E
V
K
F
L
R
-
Q
L
K
H
P
N
T
I
E
Y
K
G
C
Y
L
K
E
H
T
A
W
L
V
M
E
Y
C
LG
S
A
S
D
L
-
L
----
E
-
V
---
H
---
K
-----
K
------
P
--
L
-
Q
E
V
E
------
I
A
A
I
T
H
G
A
L
H
G
L
A
Y
L
H
S
H
A
L
I
H
R
D
I
K
A
G
N
I
L
L
-
T
E
--
P
G
Q
V
K
L
A
D
F
G
-
S
A
--------
S
M
A
--
S
P
A
N
-
S
F
--
V
G
T
P
Y
W
M
A
P
E
V
I
L
--
A
M
D
E
G
Q
Y
D
G
K
V
D
I
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
----
F
N
--
M
---
N
A
M
--
S
A
L
Y
H
I
A
----------------
Q
N
--
D
-
S
---
P
T
-
L
Q-----
S
--
N
------------
E
W
--
T
D
S
F
R
R
F
----------
V
D
Y
C
L
Q
K
I
P
Q
E
R
P
-----
T
S
A
E
L
L
R
H
D
F
V
R
------
97
Blastp_CBE
68.27
34%
-57
- C3 -
-
6I2Y
1
STK10_HUMAN
B:
[21-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
----
E
-
T
--
E
E
-
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
-
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
-
L
W
I
M
I
E
F
C
--
P
G
G
A
V
-
D
AIML
E
-
L
---
D
---
R
------------
G
--
L
-
T
E
P
Q
------
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
-
V
S
A
K
---
N
-----------------
G
T
P
Y
W
M
A
P
E
V
V
M
CE----
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
----
H
E
--
L
---
N
P
M
--
R
V
L
L
K
I
A
----------------
K
S
--
D
-
P
---
P
T
-
L
LT----
P
--
S
------------
K
W
--
S
V
E
F
R
D
F
----------
L
A
I
A
L
D
K
N
P
E
T
R
P
-----
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
---
119
Blastp_CBE
68.10
35%
-42
- C3 -
-
4LGD
1
STK3_HUMAN
D:
[33-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
---
E
S
G
Q
V
V
A
I
K
Q
V
-
P
-
V
E
-
S
D
L
Q
E
-
I
I
K
E
--------
I
S
I
M
Q
-
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
--
G
A
G
S
V
-
S
----
D
-
I
---
I
---
R
-----
L
RNK---
T
--
L
-
I
E
D
E
------
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
-
N
T
--
E
G
H
A
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
---
T
M
---
A
K
R
N
-
T
V
--
I
G
T
P
F
W
M
A
P
E
V
I
Q
--
E
I
---
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
----
A
D
--
I
---
H
P
M
--
R
A
I
F
M
I
P
----------------
T
N
--
P
-
P
---
P
T
-
F
RK----
P
--
E
------------
L
W
--
S
D
D
F
T
D
F
----------
V
K
K
C
L
V
K
N
P
E
Q
R
A
-----
T
A
T
Q
L
L
Q
H
P
F
I
K
------
62
Blastp_CBE
67.81
36%
-42
- C3 -
-
4ZJJ
1
PAK1_HUMAN
A:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
-----
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
--------
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
85
Blastp_CBE
67.76
35%
-30
- C3 -
-
5DEY
1
PAK1_HUMAN
A:
[21-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
-
Q
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
--
E
Q
S
K
-
R
S
EM
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
74
Blastp_CBE
67.68
35%
-27
- C3 -
-
4ZY5
2
PAK1_HUMAN
B:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
--
Q
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
EQ
S
K
R
S
-
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
20
PsiBlast_PDB
67.47
40%
-36
- C3 -
-
5UOR
1
M3K5_HUMAN
A:
[17-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
---
S
N
Q
V
R
I
A
I
K
E
I
----
P
-
E
R
D
S
R
-
Y
S
Q
P
L
H
-
E
---
E
I
A
L
H
K
-
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
--
P
G
G
S
L
-
S
----
A
-
L
---
L
---
R
SKWGP
L
------
K
--
D
-
N
E
Q
T
------
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
---------------
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--------
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
----
Y
E
------------
A
M
F
K
V
G
----------------
M
F
--
K
V
H
---
P
E
-
I
------
P
--
E
------------
S
M
--
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
L
K
------
115
Blastp_CBE
67.31
34%
-27
- C3 -
-
6EIM
3
STK10_HUMAN
B:
[21-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
----
E
-
T
K
S
E
E
-
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
-
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
--
P
G
G
A
V
-
D
AIML
E
-
L
---
D
---
R
------------
G
--
L
-
T
E
P
Q
------
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
-
V
S
A
K
---
N
L
K
T
L
Q
--
K
R
-
D
-
S
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
----
H
E
--
L
---
N
P
M
--
R
V
L
L
A
I
A
----------------
A
S
--
D
-
P
---
P
T
-
L
LT----
P
--
S
------------
K
W
--
S
V
E
F
R
D
F
----------
L
A
I
A
L
D
K
N
P
E
T
R
P
-----
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
---
24
Blastp_CBE
67.14
40%
-19
- C3 -
-
5VIL
2
D:
[28-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
---
S
N
Q
V
R
I
A
I
K
E
I
----
P
-
E
R
D
S
R
-
Y
S
Q
P
L
H
-
E
---
E
I
A
L
H
K
-
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
--
P
G
G
S
L
-
S
----
A
-
L
---
L
---
R
SKWGP
L
------
K
--
D
-
N
E
Q
T
------
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
---
A
G
I
N
P
--
C
T
E
T
-
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
----
Y
E
--
L
--
G
E
P
Q
--
A
A
M
F
K
V
G
----------------
M
F
--
K
V
H
---
P
E
-
I
------
P
--
E
------------
S
M
--
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
L
K
V
-----
9
PsiBlast_PDB
67.02
40%
-19
- C3 -
-
5VIO
2
M3K5_HUMAN
A:
[28-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
---
S
N
Q
V
R
I
A
I
K
E
I
----
P
-
E
R
D
S
R
-
Y
S
Q
P
L
H
-
E
---
E
I
A
L
H
K
-
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
--
P
G
G
S
L
-
S
----
A
-
L
---
L
---
R
SKWGP
L
------
K
--
D
-
N
E
Q
T
------
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
---
A
G
I
N
P
--
C
T
E
T
-
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
----
Y
E
--
L
--
G
E
P
Q
--
A
A
M
F
K
V
G
----------------
M
F
--
K
V
H
---
P
E
-
I
------
P
--
E
------------
S
M
--
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
L
K
V
-----
111
Blastp_CBE
66.98
34%
-35
- C3 -
-
4AOT
1
STK10_HUMAN
B:
[21-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
----
E
-
T
K
S
E
E
-
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
-
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
--
P
G
G
A
V
-
D
AIML
E
-
L
---
D
---
R
------------
G
--
L
-
T
E
P
Q
------
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
-
V
S
A
K
--------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
-------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
----
H
E
--
L
---
N
P
M
--
R
V
L
L
K
I
A
----------------
K
S
--
D
-
P
---
P
T
-
L
LT----
P
--
S
------------
K
W
--
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
-----
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
---
25
Blastp_CBE
66.93
40%
-16
- C3 -
-
5VIL
2
M3K5_HUMAN
C:
[28-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
---
S
N
Q
V
R
I
A
I
K
E
I
----
P
-
E
R
D
S
R
-
Y
S
Q
P
L
H
-
E
---
E
I
A
L
H
K
-
H
L
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
V
--
P
G
G
S
L
-
S
----
A
-
L
---
L
---
R
SKWGP
L
------
K
--
D
-
N
E
Q
T
------
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
--
S
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
---
A
G
I
N
P
--
C
T
E
T
-
F
T
---
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
G
P
-
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
----
Y
E
--
L
--
G
E
P
Q
--
A
A
M
F
K
V
G
----------------
M
F
--
K
V
H
---
P
E
-
I
------
P
--
E
------------
S
M
--
S
A
E
A
K
A
F
----------
I
L
K
C
F
E
P
D
P
D
K
R
A
-----
C
A
N
D
L
L
V
D
E
F
L
K
V
-----
81
Blastp_CBE
66.92
35%
-27
- C3 -
-
4O0R
1
PAK1_HUMAN
A:
[21-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
-
Q
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
--
E
Q
S
K
-
R
S
EM
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
72
Blastp_CBE
66.65
35%
-34
- C3 -
-
4ZY6
1
PAK1_HUMAN
B:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
-
Q
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
--------------
S
K
R
S
-
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
117
Blastp_CBE
66.58
35%
-59
- C3 -
-
6AO5
1
STK3_HUMAN
A:
[17-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
--------
V
V
A
I
K
Q
--------
D
L
Q
E
-
I
I
K
E
--------
I
S
I
M
Q
-
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
----
L
W
I
V
M
E
Y
C
--
G
A
G
S
V
-
S
----
D
-
I
---
I
---
R
-----
L
RNK---
T
--
L
-
I
E
D
E
------
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
-
N
T
--
E
G
H
A
K
L
A
D
F
G
-
V
A
-------------------
V
--
I
G
T
P
F
W
M
A
P
E
V
I
Q
--
E
I
---
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
----
A
D
--
I
---
H
P
M
--
R
A
I
F
M
I
P
----------------
T
N
--
P
-
P
---
P
T
-
F
RK----
P
--
E
------------
L
W
--
S
D
D
F
T
D
F
----------
V
K
K
C
L
V
K
N
P
E
Q
R
A
-----
T
A
T
Q
L
L
Q
H
P
F
I
K
------
309
HHSearch
66.01
34%
-54
- C3 -
-
6AO5
1
STK3_HUMAN
A:
[13-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
--------
V
V
A
I
K
Q
-------------
D
L
Q
E
I
I
-
K
---
E
I
S
I
M
Q
-
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
----
L
W
I
V
M
E
Y
C
--
G
A
G
S
V
-
S
----
D
-
I
---
I
---
R
LRN--
K
------
T
--
L
-
I
E
D
E
------
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
-
N
T
--
E
G
H
A
K
L
A
D
F
G
-
V
A
-------------------
V
--
I
G
T
P
F
W
M
A
P
E
V
I
Q
--
E
---
I
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
----
A
D
--
I
--
H
P
M
R
--
A
I
-
F
M
I
P
----------------
T
N
PP
P
-
T
---
F
R
-
K
------
P
--
E
------------
L
W
--
S
D
D
F
T
D
F
----------
V
K
K
C
L
V
K
N
P
E
Q
R
A
-----
T
A
T
Q
L
L
Q
H
P
F
I
K
N
A
----
128
Blastp_CBE
65.61
35%
-46
- C3 -
-
5DH3
1
STK3_HUMAN
A:
[34-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
---
E
S
G
Q
V
V
A
I
K
Q
V
-
P
-
V
E
-
S
D
L
Q
E
-
I
I
K
E
--------
I
S
I
M
Q
-
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
--
G
A
G
S
V
-
S
----
D
-
I
---
I
---
R
-----
L
RNK---
T
--
L
-
I
E
D
E
------
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
K
A
G
N
I
L
L
-
N
T
--
E
G
H
A
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
M
A
K
--------
R
-
N
V
--
I
G
T
P
F
W
M
A
P
E
V
I
Q
--
E
I
---
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
----
A
D
--
I
---
H
P
M
--
R
A
I
F
M
I
P
----------------
T
N
--
P
-
P
---
P
T
-
F
RK----
P
--
E
------------
L
W
--
S
D
D
F
T
D
F
----------
V
K
K
C
L
V
K
N
P
E
Q
R
A
-----
T
A
T
Q
L
L
Q
H
P
F
I
K
------
139
Blastp_CBE
65.48
31%
-47
- C3 -
-
4B9D
2
NEK1_HUMAN
B:
[25-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
V
R
L
Q
K
I
-----
G
K
A
I
L
V
K
S
T
---
E
D
G
R
Q
Y
V
I
K
E
I
-
N
-
I
S
-
R
M
S
S
K
-
E
R
E
E
S
R
-
R
---
E
V
A
V
L
A
-
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
G
S
L
Y
I
V
M
D
Y
C
--
E
G
G
D
L
--------
F
---
K
---
R
-----
I
------
N
--
A
-
Q
K
G
V
LFQEDQ
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
-
T
K
--
D
G
T
V
Q
L
G
D
F
G
-
I
A
R
V
L
N
S
T
V
E
L
------
A
R
-
A
C
--
I
G
T
P
Y
Y
L
S
P
E
I
-----
C
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
-------
H
A
--
F
--
E
A
G
S
MK
N
L
V
L
K
I
I
----------------
S
G
--
S
-
F
---
P
P
-
V
------
S
--
L
------------
H
Y
--
S
Y
D
L
R
S
L
----------
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
-------
76
Blastp_CBE
65.45
35%
-25
- C3 -
-
4ZY4
2
PAK1_HUMAN
B:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
--
Q
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
EQ
S
K
R
S
-
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
153
Blastp_CBE
65.44
33%
-55
- C3 -
-
5VED
1
A:
[54-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
---
S
S
G
K
L
V
A
V
K
K
M
-
D
-
L
R
-
K
Q
Q
R
R
-
E
L
--
L
F
-
N
---
E
V
V
I
M
R
-
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
G
G
A
L
-
T
----
D
I
V
---
T
---
H
-----
T
------
R
--
M
-
N
E
E
Q
------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
--
D
G
R
V
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
R
-------
R
-
K
L
--
V
G
T
P
Y
W
M
A
P
E
L
I
S
--
R
L
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
-----
E
P
P
L
--
K
A
M
K
M
I
R
----------------
D
N
--
L
-
P
---
P
R
-
L
------
K
NL
H
------------
K
V
--
S
P
S
L
K
G
F
----------
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
-------
71
Blastp_CBE
65.35
35%
-29
- C3 -
-
6B16
1
PAK1_HUMAN
A:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
--------
Q
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
--
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
EQ
S
K
R
S
-
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
163
Blastp_CBE
64.86
33%
-48
- C3 -
-
5XVA
4
PAK4_HUMAN
A:
[28-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
---
S
S
G
K
L
V
A
V
K
K
M
-
D
-
L
R
-
K
Q
Q
R
R
-
E
L
--
L
F
-
N
---
E
V
V
I
M
R
-
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
G
G
A
L
-
T
----
D
I
V
---
T
---
H
-----
T
------
R
--
M
-
N
E
E
Q
------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
--
D
G
R
V
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
R
-------
R
-
K
L
--
V
G
T
P
Y
W
M
A
P
E
L
I
S
--
R
L
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
-----
E
P
P
L
--
K
A
M
K
M
I
R
----------------
D
N
--
L
-
P
---
P
R
-
L
------
K
NL
H
------------
K
V
--
S
P
S
L
K
G
F
----------
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
-------
173
Blastp_CBE
64.85
33%
-48
- C3 -
-
2X4Z
3
A:
[31-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
---
S
S
G
K
L
V
A
V
K
K
M
-
D
-
L
R
-
K
Q
Q
R
R
-
E
L
--
L
F
-
N
---
E
V
V
I
M
R
-
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
G
G
A
L
-
T
----
D
I
V
---
T
---
H
-----
T
------
R
--
M
-
N
E
E
Q
------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
--
D
G
R
V
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
R
-------
R
-
K
L
--
V
G
T
P
Y
W
M
A
P
E
L
I
S
--
R
L
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
-----
E
P
P
L
--
K
A
M
K
M
I
R
----------------
D
N
--
L
-
P
---
P
R
-
L
------
K
NL
H
------------
K
V
--
S
P
S
L
K
G
F
----------
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
-------
161
Blastp_CBE
64.84
33%
-49
- C3 -
-
5ZJW
10
A:
[28-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
---
S
S
G
K
L
V
A
V
K
K
M
-
D
-
L
R
-
K
Q
Q
R
R
-
E
L
--
L
F
-
N
---
E
V
V
I
M
R
-
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
G
G
A
L
-
T
----
D
I
V
---
T
---
H
-----
T
------
R
--
M
-
N
E
E
Q
------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
--
D
G
R
V
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
R
-------
R
-
K
L
--
V
G
T
P
Y
W
M
A
P
E
L
I
S
--
R
L
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
-----
E
P
P
L
--
K
A
M
K
M
I
R
----------------
D
N
--
L
-
P
---
P
R
-
L
------
K
NL
H
------------
K
V
--
S
P
S
L
K
G
F
----------
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
-------
50
Blastp_CBE
64.74
36%
-35
- C3 -
-
4ZLO
2
PAK1_HUMAN
A:
[21-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
--
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-------
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-----------------
Q
S
K
R
S
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
77
Blastp_CBE
64.47
35%
-28
- C3 -
-
4ZY4
1
PAK1_HUMAN
A:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
--------
Q
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
EQ
S
K
R
S
-
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
221
Blastp_CBE
64.41
32%
-45
- C3 -
-
2F57
1
PAK5_HUMAN
A:
[52-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
---
H
T
G
K
Q
V
A
V
K
K
M
-
D
-
L
R
-
K
Q
Q
R
R
-
E
L
--
L
F
-
N
---
E
V
V
I
M
R
-
D
Y
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
G
G
A
L
-
T
----
D
I
V
---
T
---
H
-----
T
------
R
--
M
-
N
E
E
Q
------
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
S
--
D
G
R
I
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
K
-------
R
-
K
L
--
V
G
T
P
Y
W
M
A
P
E
V
I
S
--
R
L
P
---
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
----
F
N
-----
E
P
P
L
--
Q
A
M
R
R
I
R
----------------
D
S
--
L
-
P
---
P
R
-
V
------
K
--
D
LH----------
K
V
--
S
S
V
L
R
G
F
----------
L
D
L
M
L
V
R
E
P
S
Q
R
A
-----
T
A
Q
E
L
L
G
H
P
F
L
K
L
A
----
171
Blastp_CBE
64.36
33%
-51
- C3 -
-
4NJD
1
A:
[31-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
---
S
S
G
K
L
V
A
V
K
K
M
-
D
-
L
R
-
K
Q
Q
R
R
-
E
L
--
L
F
-
N
---
E
V
V
I
M
R
-
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
G
G
A
L
-
T
----
D
I
V
---
T
---
H
-----
T
------
R
--
M
-
N
E
E
Q
------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
--
D
G
R
V
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
R
-------
R
-
K
L
--
V
G
T
P
Y
W
M
A
P
E
L
I
S
--
R
L
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
-----
E
P
P
L
--
K
A
M
K
M
I
R
----------------
D
N
--
L
-
P
---
P
R
-
L
------
K
NL
H
------------
K
V
--
S
P
S
L
K
G
F
----------
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
-------
172
Blastp_CBE
64.29
33%
-48
- C3 -
-
4APP
2
A:
[31-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
---
S
S
G
K
L
V
A
V
K
K
M
-
D
-
L
R
-
K
Q
Q
R
R
-
E
L
--
L
F
-
N
---
E
V
V
I
M
R
-
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
G
G
A
L
-
T
----
D
I
V
---
T
---
H
-----
T
------
R
--
M
-
N
E
E
Q
------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
--
D
G
R
V
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
R
-------
R
-
K
L
--
V
G
T
P
Y
W
M
A
P
E
L
I
S
--
R
L
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
-----
E
P
P
L
--
K
A
M
K
M
I
R
----------------
D
N
--
L
-
P
---
P
R
-
L
------
K
NL
H
------------
K
V
--
S
P
S
L
K
G
F
----------
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
-------
73
Blastp_CBE
64.29
35%
-28
- C3 -
-
4ZY6
1
PAK1_HUMAN
A:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
---------
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
EQ
S
K
R
S
-
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
140
Blastp_CBE
64.26
31%
-49
- C3 -
-
4B9D
1
NEK1_HUMAN
A:
[25-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
---
E
D
G
R
Q
Y
V
I
K
E
I
-
N
-
I
S
-
R
M
S
S
K
-
E
R
E
E
S
R
-
R
---
E
V
A
V
L
A
-
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
G
S
L
Y
I
V
M
D
Y
C
--
E
G
G
D
L
--------
F
---
K
---
R
-----
I
------
N
--
A
-
Q
K
G
V
LFQEDQ
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
-
T
K
--
D
G
T
V
Q
L
G
D
F
G
-
I
A
R
V
L
N
S
T
V
E
L
------
A
R
-
A
C
--
I
G
T
P
Y
Y
L
S
P
E
I
-----
C
E
N
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
-------
H
A
--
F
--
E
A
G
S
MK
N
L
V
L
K
I
I
----------------
S
G
--
S
-
F
---
P
P
-
V
------
S
--
L
------------
H
Y
--
S
Y
D
L
R
S
L
----------
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
-------
70
Blastp_CBE
64.21
35%
-17
- C3 -
-
6B16
1
PAK1_HUMAN
B:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
Q
M
-
N
-
L
Q
-
Q
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
--------------EQ
S
K
R
S
-
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
132
Blastp_CBE
64.10
31%
-27
- C3 -
-
4AGU
1
CDKL1_HUMAN
A:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
---
D
T
G
Q
I
V
A
I
K
K
F
---
L
E
-
S
E
-
D
P
-
V
I
K
K
I
A
L
R
---
E
I
R
M
L
K
-
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
--
D
H
T
V
L
-
H
----
E
-
L
---
D
---
R
-----
Y
QR----
G
--
V
-
P
E
H
L
------
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
-
T
K
--
H
S
V
I
K
L
C
D
F
G
-
F
A
R
L
L
---------------------
T
R
W
Y
R
S
P
E
L
L
----
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
PGK-
S
D
--
V
--
D
Q
L
Y
--
L
I
R
K
T
L
G
DLIPRHQQVFSTNQYF
S
G
--
V
-
K
---
I
P
-
D
------
P
--
E
------------
D
M
--
E
P
L
E
L
K
F
PNISYPALGL
L
K
G
C
L
H
M
D
P
T
E
R
L
-----
T
C
E
Q
L
L
H
H
P
Y
--------
158
Blastp_CBE
64.05
33%
-49
- C3 -
-
2J0I
4
A:
[38-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
---
S
S
G
K
L
V
A
V
K
K
M
-
D
-
L
R
-
K
Q
Q
R
R
-
E
L
--
L
F
-
N
---
E
V
V
I
M
R
-
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
G
G
A
L
-
T
----
D
I
V
---
T
---
H
-----
T
------
R
--
M
-
N
E
E
Q
------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
--
D
G
R
V
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
R
-------
R
-
K
L
--
V
G
T
P
Y
W
M
A
P
E
L
I
S
--
R
L
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
-----
E
P
P
L
--
K
A
M
K
M
I
R
----------------
D
N
--
L
-
P
---
P
R
-
L
------
K
NL
H
------------
K
V
--
S
P
S
L
K
G
F
----------
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
-------
130
Blastp_CBE
63.81
31%
-27
- C3 -
-
4AGU
1
CDKL1_HUMAN
C:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
---
D
T
G
Q
I
V
A
I
K
K
F
---
L
E
-
S
E
D
D
P
-
V
I
K
K
I
A
L
R
---
E
I
R
M
L
K
-
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
--
D
H
T
V
L
-
H
----
E
-
L
---
D
---
R
-----
Y
QR----
G
--
V
-
P
E
H
L
------
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
-
T
K
--
H
S
V
I
K
L
C
D
F
G
-
F
A
R
L
L
---------------------
T
R
W
Y
R
S
P
E
L
L
----
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
PGK-
S
D
--
V
--
D
Q
L
Y
--
L
I
R
K
T
L
G
DLIPRHQQVFSTNQYF
S
G
--
V
-
K
---
I
P
-
D
------
P
--
E
------------
D
M
--
E
P
L
E
L
K
F
PNISYPALGL
L
K
G
C
L
H
M
D
P
T
E
R
L
-----
T
C
E
Q
L
L
H
H
P
Y
--------
75
Blastp_CBE
63.81
35%
-28
- C3 -
-
4ZY5
1
PAK1_HUMAN
A:
[22-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
---
A
T
G
Q
E
V
A
I
K
--------
Q
Q
P
K
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
---
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
T
P
EQ
S
K
R
S
-
T
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
E
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
170
Blastp_CBE
63.44
33%
-48
- C3 -
-
5I0B
1
A:
[31-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
---
S
S
G
K
L
V
A
V
K
K
M
-
D
-
L
R
-
K
Q
Q
R
R
-
E
L
--
L
F
-
N
---
E
V
V
I
M
R
-
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
G
G
A
L
-
T
----
D
I
V
---
T
---
H
-----
T
------
R
--
M
-
N
E
E
Q
------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
--
D
G
R
V
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
R
-------
R
-
K
L
--
V
G
T
P
Y
W
M
A
P
E
L
I
S
--
R
L
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
-----
E
P
P
L
--
K
A
M
K
M
I
R
----------------
D
N
--
L
-
P
---
P
R
-
L
------
K
NL
H
------------
K
V
--
S
P
S
L
K
G
F
----------
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
-------
156
Blastp_CBE
63.35
31%
-25
- C3 -
-
4AAA
7
CDKL2_HUMAN
A:
[26-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
---
D
T
G
R
I
V
A
I
K
K
F
---
L
E
-
S
D
D
D
K
-
M
V
K
K
I
A
M
R
---
E
I
K
L
L
K
-
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
--
D
H
T
I
L
-
D
----
D
-
L
---
E
---
L
-----
F
PN----
G
--
L
-
D
Y
Q
V
------
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
-
S
Q
--
S
G
V
V
K
L
C
D
F
G
-
F
A
-------------------
E
--
V
A
T
R
W
Y
R
A
P
E
L
L
V
----
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
P
L
F
PGD-
S
D
--
I
--
D
Q
L
Y
--
H
I
M
M
C
L
G
NLIPRHQE--------
L
F
--
N
-
K
---
N
P
-
V
FAGVRL
P
--
E
IKEREPLERRYP
K
L
--
S
E
V
V
I
D
L
----------
A
K
K
C
L
H
I
D
P
D
K
R
P
-----
F
C
A
E
L
L
H
H
D
F
F
Q
M
-----
127
Blastp_CBE
63.15
35%
-43
- C3 -
-
5DH3
1
STK3_HUMAN
B:
[34-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
---
E
S
G
Q
V
V
A
I
K
Q
V
-
P
-
V
E
-
S
D
L
Q
E
-
I
I
K
E
--------
I
S
I
M
Q
-
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
--
G
A
G
S
V
-
S
----
D
-
I
---
I
---
R
-----
L
RNK---
T
--
L
-
I
E
D
E
------
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
K
A
G
N
I
L
L
-
N
T
--
E
G
H
A
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
M
A
K
--------
R
-
N
V
--
I
G
T
P
F
W
M
A
P
E
V
I
Q
--
E
I
---
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
----
A
D
--
I
---
H
P
M
--
R
A
I
F
M
I
P
----------------
T
N
--
P
-
P
---
P
T
-
F
RK----
P
--
E
------------
L
W
--
S
D
D
F
T
D
F
----------
V
K
K
C
L
V
K
N
P
E
Q
R
A
-----
T
A
T
Q
L
L
Q
H
P
F
I
K
------
157
Blastp_CBE
63.14
33%
-42
- C3 -
-
2Q0N
7
A:
[36-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
---
S
S
G
K
L
V
A
V
K
K
M
-
D
-
L
R
-
K
Q
Q
R
R
-
E
L
--
L
F
-
N
---
E
V
V
I
M
R
-
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
--
E
G
G
A
L
-
T
----
D
I
V
---
T
---
H
-----
T
------
R
--
M
-
N
E
E
Q
------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-
T
H
--
D
G
R
V
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
R
-------
R
-
K
L
--
V
G
T
P
Y
W
M
A
P
E
L
I
S
--
R
L
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
----
F
N
-----
E
P
P
L
--
K
A
M
K
M
I
R
----------------
D
N
--
L
-
P
---
P
R
-
L
------
K
NL
H
------------
K
V
--
S
P
S
L
K
G
F
----------
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
-------
131
Blastp_CBE
63.07
31%
-27
- C3 -
-
4AGU
1
CDKL1_HUMAN
B:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
---
D
T
G
Q
I
V
A
I
K
K
F
---
L
E
-
S
--
D
P
-
V
I
K
K
I
A
L
R
---
E
I
R
M
L
K
-
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
--
D
H
T
V
L
-
H
----
E
-
L
---
D
---
R
-----
Y
QR----
G
--
V
-
P
E
H
L
------
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
-
T
K
--
H
S
V
I
K
L
C
D
F
G
-
F
A
R
L
L
---------------------
T
R
W
Y
R
S
P
E
L
L
----
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
PGK-
S
D
--
V
--
D
Q
L
Y
--
L
I
R
K
T
L
G
DLIPRHQQVFSTNQYF
S
G
--
V
-
K
---
I
P
-
D
------
P
--
E
------------
D
M
--
E
P
L
E
L
K
F
PNISYPALGL
L
K
G
C
L
H
M
D
P
T
E
R
L
-----
T
C
E
Q
L
L
H
H
P
Y
--------
123
Blastp_CBE
62.66
33%
-39
- C3 -
-
6HXF
4
STK10_HUMAN
D:
[21-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
----
E
-
T
K
S
E
E
-
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
-
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
--
P
G
G
A
V
-
D
AIML
E
-
L
---
D
---
R
------------
G
--
L
-
T
E
P
Q
------
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
-
V
S
------
A
K
N
L
K
--
L
Q
K
R
-
D
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
C-
E
M
K
--
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
----
H
E
--
L
---
N
P
M
--
R
V
L
L
K
I
A
----------------
K
S
--
D
-
P
---
P
T
-
L
LT----
P
--
S
------------
K
W
--
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
-----
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
---
305
HHSearch
62.52
33%
-25
- C3 -
-
5J5T
1
M4K3_HUMAN
A:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
---
N
T
G
E
L
A
A
I
K
V
I
-
K
-
L
E
-
P
--
G
E
-
D
F
A
V
V
Q
-
Q
---
E
I
I
M
M
K
-
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
--
G
G
G
S
L
-
Q
----
D
-
I
---
Y
---
H
-----
V
TG----
P
--
L
-
S
E
L
Q
------
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
-
T
D
--
N
G
H
V
K
L
A
D
F
G
-
V
S
A
Q
I
T
A
T
I
A
----------
A
F
--
I
G
T
P
Y
W
M
A
P
E
V
A
A
--
V
E
R
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
----
F
D
--
L
--
H
P
M
R
--
A
L
F
L
M
T
K
----------------
S
N
--
F
-
Q
PPK
L
K
-
D
------
K
--
M
------------
K
W
--
S
N
S
F
H
H
F
----------
V
K
M
A
L
T
K
N
P
K
K
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
-----
93
Blastp_CBE
61.92
35%
-29
- C3 -
-
4P90
1
PAK1_HUMAN
A:
[21-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
---------
E
V
A
I
K
Q
M
----------
K
-
E
L
--
I
I
-
N
---
E
I
L
V
M
R
-
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
---
E
L
W
V
V
M
E
Y
L
--
A
G
G
S
L
-
T
----
D
-
V
V--
T
---
E
-----
T
------
C
--
M
-
D
E
G
Q
------
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
--
D
G
S
V
K
L
T
D
F
G
-
F
C
------
A
Q
I
-------
K
-
R
S
EM
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
R
---
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
----
L
N
-----
E
N
P
L
--
R
A
L
Y
L
I
A
----------------
T
N
--
G
-
T
---
P
E
-
L
QN----
P
--
E
------------
K
L
--
S
A
I
F
R
D
F
----------
L
N
R
C
L
D
M
D
V
E
K
R
G
-----
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-----
51
Blastp_CBE
60.63
37%
-2
- C3 -
-
6HVD
4
SLK_HUMAN
A:
[18-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
---
E
T
S
V
L
A
A
A
K
V
I
--------
D
T
K
-
S
E
E
E
L
E
-
D
YMV
E
I
D
I
L
A
-
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
--
A
G
G
A
V
-
D
----
A
-
V
---
M
LEL
E
-----
R
------
P
--
L
-
T
E
S
Q
------
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
-
V
S
A
K
---
N
T
R
----------
S
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
----
H
E
--
L
---
N
P
M
--
R
V
L
L
K
I
A
----------------
K
S
--
E
-
P
---
P
T
-
L
AQ----
P
--
S
------------
R
W
--
S
S
N
F
K
D
F
----------
L
K
K
C
L
E
K
N
V
D
A
R
W
-----
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-----
125
Blastp_CBE
60.13
33%
-27
- C3 -
-
6HXF
5
STK10_HUMAN
B:
[21-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
---
E
T
G
A
L
A
A
A
K
V
I
----
E
-
T
K
S
E
E
-
E
L
E
D
Y
I
-
V
---
E
I
E
I
L
A
-
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
--
P
G
G
A
V
-
D
AIML
E
-
L
---
D
---
R
------------
G
--
L
-
T
E
P
Q
------
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
--
E
G
D
I
R
L
A
D
F
G
-
V
S
------
A
K
N
L
K
--
L
Q
K
R
-
D
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
C-
E
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
----
H
E
--
L
---
N
P
M
--
R
V
L
L
K
I
A
----------------
K
S
--
D
-
P
---
P
T
-
L
LT----
P
--
S
------------
K
W
--
S
V
E
F
R
D
F
----------
L
K
I
A
L
D
K
N
P
E
T
R
P
-----
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
---
68
Blastp_CBE
60.05
37%
-0
- C3 -
-
2J51
5
SLK_HUMAN
A:
[39-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
---
E
T
S
V
L
A
A
A
K
V
I
--------
D
T
K
-
S
E
E
E
L
E
-
D
YMV
E
I
D
I
L
A
-
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
--
A
G
G
A
V
-
D
----
A
-
V
---
M
LEL
E
-----
R
------
P
--
L
-
T
E
S
Q
------
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
-
V
S
A
K
---
N
T
R
T
I
Q
--
R
R
-
D
-
S
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
----
H
E
--
L
---
N
P
M
--
R
V
L
L
K
I
A
----------------
K
S
--
E
-
P
---
P
T
-
L
AQ----
P
--
S
------------
R
W
--
S
S
N
F
K
D
F
----------
L
K
K
C
L
E
K
N
V
D
A
R
W
-----
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-----
129
Blastp_CBE
59.89
33%
-21
- C3 -
-
5J5T
1
M4K3_HUMAN
A:
[11-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
---
N
T
G
E
L
A
A
I
K
V
I
-
K
-
L
E
-
P
G
E
D
F
-
A
V
V
Q
---
Q
---
E
I
I
M
M
K
-
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
--
G
G
G
S
L
-
Q
----
D
-
I
---
Y
---
H
-----
V
------
T
GP
L
-
S
E
L
Q
------
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
-
T
D
--
N
G
H
V
K
L
A
D
F
G
-
V
S
A
Q
I
T
A
T
I
------
A
----
A
F
--
I
G
T
P
Y
W
M
A
P
E
V
A
A
--
V
E
R
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
----
F
D
--
L
--
H
P
M
R
--
A
L
F
L
M
T
K
----------------
S
N
--
F
-
Q
---
P
P
K
L
------
K
--
D
------------
K
M
KW
S
N
S
F
H
H
F
----------
V
K
M
A
L
T
K
N
P
K
K
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
-------
67
Blastp_CBE
58.79
37%
1
- C3 -
-
2UV2
6
SLK_HUMAN
A:
[39-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
---
E
T
S
V
L
A
A
A
K
V
I
--------
D
T
K
-
S
E
E
E
L
E
-
D
YMV
E
I
D
I
L
A
-
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
--
A
G
G
A
V
-
D
----
A
-
V
---
M
LEL
E
-----
R
------
P
--
L
-
T
E
S
Q
------
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
-
V
S
A
K
---
N
T
R
T
I
Q
--
R
R
-
D
-
S
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
----
H
E
--
L
---
N
P
M
--
R
V
L
L
K
I
A
----------------
K
S
--
E
-
P
---
P
T
-
L
AQ----
P
--
S
------------
R
W
--
S
S
N
F
K
D
F
----------
L
K
K
C
L
E
K
N
V
D
A
R
W
-----
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-----
194
Blastp_CBE
58.50
31%
-15
- C3 -
-
4W8D
1
STK24_HUMAN
A:
[21-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
195
Blastp_CBE
58.42
31%
-16
- C3 -
-
4U8Z
1
STK24_HUMAN
A:
[21-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
213
Blastp_CBE
58.32
31%
-15
- C3 -
-
4QMO
3
STK24_HUMAN
A:
[36-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
218
Blastp_CBE
58.07
31%
-26
- C3 -
-
2GCD
1
TAOK2_RAT
B:
[22-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
---
R
N
S
E
V
V
A
I
K
K
M
-
S
-
Y
S
G
K
Q
S
N
E
-
K
W
Q
D
I
I
-
K
---
E
V
R
F
L
Q
-
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
W
L
V
M
E
Y
C
LG
S
A
S
D
L
-
L
----
E
-
V
---
H
---
K
-----
K
------
P
--
L
-
Q
E
V
E
------
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
-
S
E
--
P
G
L
V
K
L
G
D
F
G
--------
S
A
S
I
M
A
--
P
A
---
N
F
--
V
G
T
P
Y
W
M
A
P
E
V
I
L
--
A
M
D
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
----
F
N
--
M
---
N
A
M
--
S
A
L
Y
H
I
A
----------------
Q
N
--
E
-
S
---
P
A
-
L
------
Q
--
S
G-----------
H
W
--
S
E
Y
F
R
N
F
----------
V
D
S
C
L
Q
K
I
P
Q
D
R
P
-----
T
S
E
V
L
L
K
H
R
F
V
-------
202
Blastp_CBE
57.32
31%
-13
- C3 -
-
4QNA
1
STK24_HUMAN
A:
[36-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
197
Blastp_CBE
57.28
31%
-14
- C3 -
-
3A7I
1
STK24_HUMAN
A:
[29-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
317
HHSearch
57.27
31%
-24
- C3 -
-
5VCY
6
PMYT1_HUMAN
A:
[56-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
S
-
F
Q
R
L
S
R
L
G
H
G
S
Y
G
E
V
F
K
V
R
S
K
---
E
D
G
R
L
Y
A
V
K
R
S
-
M
-
S
P
-
F
R
G
P
K
D
R
A
R
K
L
A
-
E
---
V
G
S
H
E
K
-
V
G
Q
H
P
C
C
V
R
L
E
Q
A
W
E
E
G
G
I
L
Y
L
Q
T
E
L
C
---
G
P
S
L
-
Q
----
Q
-
H
---
C
---
E
-----
A
WGA---
S
--
L
-
P
E
A
Q
------
V
W
G
Y
L
R
D
T
L
L
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
L
-
G
P
--
R
G
R
C
K
L
G
D
F
G
-
L
L
V
E
L
G
T
A
G
-------
A
G
E
-
V
Q
--
E
G
D
P
R
Y
M
A
P
E
L
L
Q
--
G
----
S
Y
G
T
A
A
D
V
F
S
L
G
L
T
I
L
E
V
A
C
N
M
E
L
P
----
H
G
--
G
--
E
G
W
Q
--
Q
L
R
-
Q
------------------
G
Y
--
L
-
P
---
P
E
-
F
------
T
--
A
------------
G
L
--
S
S
E
L
R
S
V
----------
L
V
M
M
L
E
P
D
P
K
L
R
A
-----
T
A
E
A
L
L
A
L
P
V
L
R
Q
-----
207
Blastp_CBE
57.26
31%
-14
- C3 -
-
4QMV
3
STK24_HUMAN
A:
[36-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
193
Blastp_CBE
57.23
31%
-16
- C3 -
-
4W8E
1
STK24_HUMAN
A:
[21-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
206
Blastp_CBE
57.01
31%
-13
- C3 -
-
4QMW
2
STK24_HUMAN
A:
[36-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
219
Blastp_CBE
56.98
31%
-20
- C3 -
-
2GCD
1
TAOK2_RAT
A:
[22-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
---
R
N
S
E
V
V
A
I
K
K
M
-
S
-
Y
S
G
K
Q
S
N
E
-
K
W
Q
D
I
I
-
K
---
E
V
R
F
L
Q
-
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
W
L
V
M
E
Y
C
LG
S
A
S
D
L
-
L
----
E
-
V
---
H
---
K
-----
K
------
P
--
L
-
Q
E
V
E
------
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
-
S
E
--
P
G
L
V
K
L
G
D
F
G
--------
S
A
S
I
M
A
--
P
A
---
N
F
--
V
G
T
P
Y
W
M
A
P
E
V
I
L
--
A
M
D
E
G
Q
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
----
F
N
--
M
---
N
A
M
--
S
A
L
Y
H
I
A
----------------
Q
N
--
E
-
S
---
P
A
-
L
------
Q
--
S
G-----------
H
W
--
S
E
Y
F
R
N
F
----------
V
D
S
C
L
Q
K
I
P
Q
D
R
P
-----
T
S
E
V
L
L
K
H
R
F
V
-------
216
Blastp_CBE
56.60
31%
-11
- C3 -
-
4QML
2
STK24_HUMAN
A:
[36-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
198
Blastp_CBE
56.50
31%
-12
- C3 -
-
3A7H
1
STK24_HUMAN
B:
[29-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
200
Blastp_CBE
56.02
31%
-12
- C3 -
-
4QO9
4
STK24_HUMAN
B:
[36-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
201
Blastp_CBE
55.52
31%
-11
- C3 -
-
4QO9
4
STK24_HUMAN
A:
[36-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
---
R
T
Q
K
V
V
A
I
K
I
I
-
D
-
L
E
--
E
A
E
D
-
E
I
E
D
I
Q
-
Q
---
E
I
T
V
L
S
-
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
--
G
G
G
S
A
-
L
----
D
-
L
---
L
---
E
-----
P
------
G
P-
L
-
D
E
T
Q
------
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
--
H
G
E
V
K
L
A
D
F
G
-
V
A
G
Q
L
T
D
T
Q
I
K
-------
R
-
N
F
--
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
-----
H
S
--
E
--
L
H
P
M
--
K
V
L
F
L
I
P
----------------
K
N
--
N
-
P
---
P
T
-
L
------
E
--
G
------------
N
Y
--
S
K
P
L
K
E
F
----------
V
E
A
C
L
N
K
E
P
S
F
R
P
-----
T
A
K
E
L
L
K
H
K
F
I
-------
96
Blastp_CBE
55.13
36%
-10
- C3 -
-
2JFL
6
SLK_HUMAN
A:
[39-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
---
E
T
S
V
L
A
A
A
K
V
I
--------
D
T
K
-
S
E
E
E
L
E
-
D
YMV
E
I
D
I
L
A
-
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
--
A
G
G
A
V
-
D
----
A
-
V
---
M
LEL
E
-----
R
------
P
--
L
-
T
E
S
Q
------
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
--
D
G
D
I
K
L
A
D
F
G
-
V
S
A
K
---
N
T
R
I
-----
Q
R
R
-
D
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
----
H
E
--
L
---
N
P
M
--
R
V
L
L
K
I
A
----------------
K
S
--
E
-
P
---
P
T
-
L
AQ----
P
--
S
------------
R
W
--
S
S
N
F
K
D
F
----------
L
K
K
C
L
E
K
N
V
D
A
R
W
-----
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-----
230
Blastp_CBE
49.33
33%
-5
- C3 -
-
3ZH8
5
KPCI_HUMAN
B:
[13-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
---
K
T
D
R
I
Y
A
M
K
V
V
-
K
-
K
E
L
V
N
D
D
E
-
D
I
D
W
V
Q
-
T
---
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
--
N
G
G
D
L
-
M
FHM-
Q
-
R
---
Q
---
R
-----
K
------
L
--
P
-
E
E
H
A
-------
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
-
D
S
--
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
------
P
--
G
D
T
T
-
S
F
--
C
G
T
P
N
Y
I
A
P
E
I
L
-----
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DIVG---------
T
E
--
D
Y
L
F
Q
V
I
----------------
L
E
--
K
-
Q
---
I
R
-
I
------
P
--
R
------------
S
L
--
S
V
K
A
A
S
V
----------
L
K
S
F
L
N
K
D
P
K
E
R
------------------------
244
Blastp_CBE
49.19
33%
-5
- C3 -
-
5LI9
13
KPCI_HUMAN
A:
[14-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
---
K
T
D
R
I
Y
A
M
K
V
V
-
K
-
K
E
L
V
N
D
D
E
-
D
I
D
W
V
Q
-
T
---
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
--
N
G
G
D
L
-
M
FHM-
Q
-
R
---
Q
---
R
-----
K
------
L
--
P
-
E
E
H
A
-------
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
-
D
S
--
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
------
P
--
G
D
T
T
-
S
F
--
C
G
T
P
N
Y
I
A
P
E
I
L
-----
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D-------------
E
--
D
Y
L
F
Q
V
I
----------------
L
E
--
K
-
Q
---
I
R
-
I
------
P
--
R
------------
S
L
--
S
V
K
A
A
S
V
----------
L
K
S
F
L
N
K
D
P
K
E
R
------------------------
243
Blastp_CBE
45.63
33%
11
- C3 -
-
3A8W
1
KPCI_HUMAN
A:
[17-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
---
K
T
D
R
I
Y
A
M
K
V
V
-
K
-
K
E
L
V
N
-----
I
D
W
V
Q
-
T
---
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
--
N
G
G
D
L
-
M
FHM-
Q
-
R
---
Q
---
R
-----
K
------
L
--
P
-
E
E
H
A
-------
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
-
D
S
--
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
------
P
--
G
D
T
T
-
S
F
--
C
G
T
P
N
Y
I
A
P
E
I
L
-----
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DI------------
E
--
D
Y
L
F
Q
V
I
----------------
L
E
--
K
-
Q
---
I
R
-
I
------
P
--
R
------------
S
L
--
S
V
K
A
A
S
V
----------
L
K
S
F
L
N
K
D
P
K
E
R
------------------------
242
Blastp_CBE
45.18
33%
6
- C3 -
-
3A8W
1
KPCI_HUMAN
B:
[17-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
---
K
T
D
R
I
Y
A
M
K
V
V
-
K
-
K
E
L
V
N
D
D
E
-
D
I
D
W
V
Q
-
T
---
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
--
N
G
G
D
L
-
M
FHM-
Q
-
R
---
Q
---
R
-----
K
------
L
--
P
-
E
E
H
A
-------
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
-
D
S
--
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
-----------
G
D
T
T
-
S
F
--
C
G
T
P
N
Y
I
A
P
E
I
L
-----
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DI------------
E
--
D
Y
L
F
Q
V
I
----------------
L
E
--
K
-
Q
---
I
R
-
I
------
P
--
R
------------
S
L
--
S
V
K
A
A
S
V
----------
L
K
S
F
L
N
K
D
P
K
E
R
------------------------
234
Blastp_CBE
44.18
33%
7
- C3 -
-
5LIH
3
KPCI_HUMAN
A:
[13-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
---
K
T
D
R
I
Y
A
M
K
V
V
-
K
-
K
E
L
V
--------
W
V
Q
-
T
---
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
--
N
G
G
D
L
-
M
FHM-
Q
-
R
---
Q
---
R
-----
K
------
L
--
P
-
E
E
H
A
-------
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
-
D
S
--
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
------
P
--
G
D
T
T
-
S
F
--
C
G
T
P
N
Y
I
A
P
E
I
L
-----
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DIV---------
N
T
E
--
D
Y
L
F
Q
V
I
----------------
L
E
--
K
-
Q
---
I
R
-
I
------
P
--
R
------------
S
L
--
S
V
K
A
A
S
V
----------
L
K
S
F
L
N
K
D
P
K
E
R
------------------------
274
Blastp_CBE
43.27
32%
-1
- C3 -
-
3A61
1
KS6B1_HUMAN
A:
[25-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
-----------------
K
-
A
---
E
R
N
I
L
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
--
S
G
G
E
L
F
M
----
Q
-
L
---
E
---
R
-----
E
------
G
--
I
F
M
E
D
T
------
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
-
N
H
--
Q
G
H
V
K
L
T
D
F
G
--------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
--
G
--
E
N
R
K
--
K
T
I
D
K
I
-----------------
L
K
--
C
-
K
---
L
N
-
L
------
P
--
P
------------
Y
L
--
T
Q
E
A
R
D
L
----------
L
K
K
L
L
K
R
N
A
A
S
R
L
-----
G
A
G
---------------
293
Blastp_CBE
42.35
32%
6
- C3 -
-
4RLO
4
KS6B1_HUMAN
B:
[13-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
-
K
K-----------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
--
S
G
G
E
L
F
M
----
Q
-
L
---
E
---
R
-----
E
------
G
--
I
F
M
E
D
T
------
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
-
N
H
--
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
---------------------
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
--
G
--
E
N
R
K
--
K
T
I
D
K
I
-----------------
L
K
--
C
-
K
---
L
N
-
L
------
P
--
P
------------
Y
L
--
T
Q
E
A
R
D
L
----------
L
K
K
L
L
K
R
N
A
A
S
R
L
-----
G
A
G
---------------
238
Blastp_CBE
42.31
33%
15
- C3 -
-
6ILZ
1
KPCI_HUMAN
C:
[17-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
------
D
R
I
Y
A
M
K
V
V
-
K
-
K
E
L
V
N
D
D
E
-
D
I
D
W
V
Q
-
T
---
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
--
N
G
G
D
L
-
M
FHM-
Q
-
R
---
Q
---
R
-----
K
------
L
--
P
-
E
E
H
A
-------
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
-
D
S
--
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
------
P
--
G
D
T
T
-
S
F
--
C
G
T
P
N
Y
I
A
P
E
I
L
-----
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DI---------------
D
Y
L
F
Q
V
I
----------------
L
E
--
K
-
Q
---
I
R
-
I
------
P
--
R
------------
S
L
--
S
V
K
A
A
S
V
----------
L
K
S
F
L
N
K
D
P
K
E
R
------------------------
275
Blastp_CBE
42.19
32%
3
- C3 -
-
3A60
1
KS6B1_HUMAN
B:
[25-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
-
K
K-----------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
--
S
G
G
E
L
F
M
----
Q
-
L
---
E
---
R
-----
E
------
G
--
I
F
M
E
D
T
------
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
-
N
H
--
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
--------------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
--
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
-----
T
--
G
--
E
N
R
K
--
K
T
I
D
K
I
-----------------
L
K
--
C
-
K
---
L
N
-
L
------
P
--
P
------------
Y
L
--
T
Q
E
A
R
D
L
----------
L
K
K
L
L
K
R
N
A
A
S
R
L
-----
G
A
G
---------------
233
Blastp_CBE
41.06
33%
19
- C3 -
-
5LIH
3
KPCI_HUMAN
B:
[13-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
K
---
K
T
D
R
I
Y
A
M
K
V
V
-
K
-
K
E
L----------
V
Q
-
T
---
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
--
N
G
G
D
L
-
M
FHM-
Q
-
R
---
Q
---
R
-----
K
------
L
--
P
-
E
E
H
A
-------
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
-
D
S
--
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
------
P
--
G
D
T
T
-
S
F
--
C
G
T
P
N
Y
I
A
P
E
I
L
-----
R
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
DI------------
E
--
D
Y
L
F
Q
V
I
----------------
L
E
--
K
-
Q
---
I
R
-
I
------
P
--
R
------------
S
L
--
S
V
K
A
A
S
V
----------
L
K
S
F
L
N
K
D
P
K
E
R
------------------------