@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OXSR1_HUMAN: (2021-11-23 )
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
Atome Classification :
(164 SA)
.........10........20-----........30-........40-.--......-.50...-..--...----60.....-...-70.........80....------....90........100.......110......--.120.......130.......140--.-......150.---.---..-..---------.---------160.......170.......180-...-....190....-.--.----.-200.--.----...-...210.......220.......230---...-......----240.--......250.......260.......270.......280.......290..-......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSEDSSALPWSINRD
D
Y
E
L
Q
E
-----
V
IGS
G
A
T
A
V
V
-
Q
A
A
YCAPKK
E
-
K
--
V
A
I
K
RI-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q-C-HHP
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
LSGG
S
V
L
D
I
I
K
H
I
V
AKGEHKSGVL--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
KNG
Q
--
I
-
H
R
D
VKAG
N
I
L
---L---GE-DG---------
S
---------
V
Q
I
A
D
FG
V
S
A
F
LATGGD
I
T
R
N
K
V
-
R
K
T-FVGTPCWM
A
P
E
-
V
--
M
----
E
-
Q
-
V
R--G----YDF-K
A
D
I
W
SFG
I
T
A
I
E
LATGAAPYHKY-----PP
M
-
K
V
L
M
L
T
----LQND--PPSLETGV
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
QKDPEKR
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-AK
N
K
E
F
L
Q
E
K
T
LQRAP
T
I
S
E
R
A
K
K
V
R
RVPGSSGRLHKTEDGGWEWSDDEFDEE
S
E
E
G
K
A
A
I
S
Q
LRSP
R
V
K
ESISNSELFPTTDP
V
G
T
L
L
Q
V
P
E
Q
I
S
A
HLPQP
A
G
QIATQP
T
Q
VSLPPTAE
P
A
K
T
A
Q
A
L
SSGSGSQETK
I
P
I
S
L
V
L
R
L
RNSKKELN
D
I
R
F
E
FTPGR
D
T
A
E
G
V
S
Q
E
L
I
S
A
GLVDG
R
D
L
V
I
V
A
A
N
L
Q
K
I
V
EEPQSN
R
S
V
T
F
K
LASGVEGSDIPDDG
K
L
I
G
F
A
Q
L
SIS
25
Blastp_CBE
90.40
100%
-110
- C2 -
-
3DAK
1
OXSR1_HUMAN
D:
[2-290]
------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
Y
C
A
P
K
K
E
-
K
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N
-------
F
V
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
HHSearch
90.25
100%
-113
- C2 -
-
3DAK
1
OXSR1_HUMAN
D:
[2-289]
------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
Y
C
A
P
K
K
E
-
K
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N
-------
F
V
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
90.22
100%
-115
- C2 -
-
3DAK
1
OXSR1_HUMAN
C:
[2-290]
------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
Y
C
A
P
K
K
E
-
K
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
---------
T
-
F
V
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.85
100%
-118
- C2 -
-
3DAK
1
OXSR1_HUMAN
A:
[1-290]
-----
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
Y
C
A
P
K
K
E
-
K
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
-------------
V
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
HHSearch
89.56
100%
-120
- C2 -
-
3DAK
1
OXSR1_HUMAN
A:
[1-289]
-----
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
Y
C
A
P
K
K
E
-
K
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
-------------
V
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
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S
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R
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M
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C
L
Q
K
D
P
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R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
HHSearch
89.09
86%
-128
- C2 -
-
5DBX
1
STK39_MOUSE
A:
[3-303]
------
A
V
G
W
P
I
-
R
D
A
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
L
C
K
P
R
Q
E
-
R
--
V
A
I
K
R
I
-
N
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Q
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T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
---
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
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Y
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N
R
G
E
H
K
N
G
V
L
--
E
E
A
I
I
A
T
I
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K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
--
I
-
H
R
D
L
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
---------------
F
V
G
T
P
-
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
T
L
E
T
G
V
E
D
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
-
K
F
-
F
Q
K
-
A
K
N
R
E
Y
L
I
E
K
L
L
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
88.98
100%
-108
- C2 -
-
2VWI
1
OXSR1_HUMAN
D:
[6-298]
-----
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
Y
C
A
P
K
K
E
-
K
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
----------
T
-
F
V
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
K
N
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
88.70
100%
-113
- C2 -
-
3DAK
1
OXSR1_HUMAN
B:
[1-290]
-----
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
Y
C
A
P
K
K
E
-
K
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
--------------
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.64
84%
-128
- C2 -
-
5DBX
1
STK39_MOUSE
A:
[3-303]
------
A
V
G
W
P
I
-
R
D
A
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
L
C
K
P
R
Q
E
-
R
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
---
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
G
E
H
K
N
G
V
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
--
I
-
H
R
D
L
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
---------------
F
V
G
T
P
-
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
T
L
E
T
G
V
E
D
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
-
K
F
-
F
Q
K
-
A
K
N
R
E
Y
L
I
E
K
L
L
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
88.60
85%
-113
- C2 -
-
5D9H
1
STK39_MOUSE
B:
[10-309]
------
A
V
G
W
P
I
C
R
D
A
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
L
C
K
P
R
Q
E
-
R
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
G
E
H
K
N
G
V
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
--
I
-
H
R
D
L
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
V
T
R
N
---------
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
T
L
E
T
G
V
E
D
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
-
A
K
N
R
E
Y
L
I
E
K
L
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.87
85%
-113
- C2 -
-
5D9H
1
STK39_MOUSE
A:
[10-308]
------
A
V
G
W
P
I
C
R
D
A
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
L
C
K
P
R
Q
E
-
R
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
G
E
H
K
N
G
V
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
--
I
-
H
R
D
L
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
V
T
R
---------
V
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
T
L
E
T
G
V
--
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
-
A
K
N
R
E
Y
L
I
E
K
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
86.61
100%
-123
- C2 -
-
2VWI
1
OXSR1_HUMAN
C:
[9-291]
--------
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
Y
C
A
P
K
K
E
-
K
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N
K
-------
V
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
--------
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
HHSearch
86.45
86%
-120
- C2 -
-
5DBX
1
STK39_MOUSE
B:
[3-302]
------
A
V
G
W
P
I
-
R
D
A
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
L
C
K
P
R
Q
E
-
R
--
V
A
I
K
R
I
-
N
L
E
K
-------
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
---
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
G
E
H
K
N
G
V
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
--
I
-
H
R
D
L
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
------------
F
V
G
T
P
-
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
T
L
E
T
G
V
E
D
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
-
K
F
-
F
Q
K
-
A
K
N
R
E
Y
L
I
E
K
L
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
85.76
85%
-121
- C2 -
-
5DBX
1
STK39_MOUSE
B:
[3-302]
------
A
V
G
W
P
I
-
R
D
A
Y
E
L
Q
E
-----
V
I
G
S
G
A
T
A
V
V
-
Q
A
A
L
C
K
P
R
Q
E
-
R
--
V
A
I
K
R
I
-
N
L
E
K
-------
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
S
-
H
-
P
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
G
E
H
K
N
G
V
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
--
I
-
H
R
D
L
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
------------
F
V
G
T
P
-
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
T
L
E
T
G
V
E
D
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
-
K
F
-
F
Q
K
-
A
K
N
R
E
Y
L
I
E
K
L
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
82.76
100%
-122
- C2 -
-
2VWI
1
OXSR1_HUMAN
B:
[9-292]
--------
P
W
S
I
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
S
---
A
V
V
-
Q
A
A
Y
C
A
P
K
K
E
-
K
--
V
A
I
K
R
I
-
N
L
E
K
C
Q
-
T
S
--
M
D
E
----
L
L
K
E
I
Q
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
--------------
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
G
-----
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
HHSearch
74.61
100%
-125
- C2 -
-
2VWI
2
OXSR1_HUMAN
A:
[13-291]
------------
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
---
T
A
V
V
-
Q
A
A
Y
C
----
E
-
K
--
V
A
I
K
R
I
-
N
-----------------------
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
-----------------
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
-----
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.61
100%
-125
- C2 -
-
2VWI
2
OXSR1_HUMAN
A:
[13-291]
------------
N
R
D
D
Y
E
L
Q
E
-----
V
I
G
---
T
A
V
V
-
Q
A
A
Y
C
----
E
-
K
--
V
A
I
K
R
I
-
N
-----------------------
A
-
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
G
E
-
D
G
---------
S
---------
V
Q
I
A
D
F
G
V
S
A
F
L
A
-----------------
G
T
P
C
W
M
A
P
E
-
V
--
M
----
E
-
Q
-
V
R
--
G
----
Y
D
F
-
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-----
P
P
M
-
K
V
L
M
L
T
----
L
Q
N
D
--
P
P
S
L
E
T
-----
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
68.53
40%
-111
- C2 -
-
4ZY5
2
PAK1_HUMAN
B:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
-
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
68.13
40%
-110
- C2 -
-
4ZY4
2
PAK1_HUMAN
B:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
-
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
67.96
40%
-110
- C2 -
-
6B16
1
PAK1_HUMAN
B:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
------------
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
66.68
40%
-112
- C2 -
-
4ZY6
1
PAK1_HUMAN
B:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
-------------
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
66.21
41%
-120
- C2 -
-
4ZLO
2
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
--
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
-------
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
D
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
--------------
Q
S
-
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
65.67
46%
-87
- C2 -
-
4O27
1
STK24_HUMAN
B:
[12-270]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
E
------
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
65.52
44%
-96
- C2 -
-
4FZD
1
STK26_HUMAN
B:
[14-272]
--------------------
E
-----
R
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
Q
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
Q
G
---------
D
---------
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
------
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
Q
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-----
H
P
M
-
R
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
65.52
45%
-85
- C2 -
-
3A7H
1
STK24_HUMAN
A:
[28-286]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
-----
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
65.31
41%
-102
- C2 -
-
6FD3
3
PAK3_HUMAN
A:
[24-279]
----------------
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
L
D
I
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
D
F
L
H
S
N
Q
V
--
I
-
H
R
D
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
V
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
----
Q
N
P
E
R
L
S
A
V
---
F
R
D
F
L
N
R
C
L
E
M
D
V
D
R
R
G
S
A
K
E
L
L
Q
H
P
F
-
L
K
L
-
D
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.23
45%
-84
- C2 -
-
3A7J
1
STK24_HUMAN
A:
[28-286]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
-----
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
65.14
45%
-84
- C2 -
-
3A7I
1
STK24_HUMAN
A:
[28-286]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
-----
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
65.03
40%
-72
- C2 -
-
5DEW
1
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
64.87
40%
-105
- C2 -
-
6B16
1
PAK1_HUMAN
A:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
------
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
--------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
64.70
40%
-72
- C2 -
-
4O0R
1
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
64.42
40%
-74
- C2 -
-
5DEY
1
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
64.27
40%
-108
- C2 -
-
4ZY6
1
PAK1_HUMAN
A:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
--------
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.26
46%
-105
- C2 -
-
4NZW
1
STK25_HUMAN
B:
[28-284]
---------------------------
I
G
K
G
S
F
G
E
V
-
Y
K
G
I
D
N
H
T
K
E
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
---------
P
G
P
L
--
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
Q
G
---------
D
---------
V
K
L
A
A
F
G
V
A
---------------------
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
----------
Y
D
F
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
-----
H
P
M
-
R
V
L
F
L
I
----
P
K
N
S
--
P
P
T
L
E
G
---------
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
T
K
K
T
S
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
64.17
44%
-96
- C2 -
-
3GGF
1
STK26_HUMAN
B:
[29-287]
--------------------
E
-----
R
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
Q
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
Q
G
---------
D
---------
V
K
L
A
D
F
G
V
A
----------------
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
Q
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-----
H
P
M
-
R
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
63.77
44%
-96
- C2 -
-
3GGF
1
STK26_HUMAN
A:
[29-287]
--------------------
E
-----
R
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
Q
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
Q
G
---------
D
---------
V
K
L
A
D
F
G
V
A
---------------
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
Q
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-----
H
P
M
-
R
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
63.67
40%
-104
- C2 -
-
4ZY4
1
PAK1_HUMAN
A:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
------
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
63.59
40%
-69
- C2 -
-
5KBQ
1
PAK1_HUMAN
A:
[14-272]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
63.29
39%
-121
- C2 -
-
6AO5
1
STK3_HUMAN
A:
[13-274]
-----------------
D
V
L
E
-----
K
L
G
E
G
S
Y
G
S
V
-
F
K
A
I
H
------
V
--
V
A
I
K
Q
----------
D
--
L
Q
E
----
I
I
K
E
I
S
I
-
M
Q
Q
-
C
-
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
----------
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
-------
R
N
K
T
L
--
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
--
I
-
H
R
N
I
K
A
G
N
I
L
---
L
---
N
T
-
E
G
---------
H
---------
A
K
L
A
D
F
G
V
A
-------------------
V
I
G
T
P
F
W
M
A
P
E
-
V
--
I
----
Q
-
E
-
I
---
G
----
Y
N
C
-
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
-----
H
P
M
-
R
A
I
F
M
I
----
P
T
N
P
--
P
P
T
F
R
K
P
-------
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
-
I
K
N
-
A
K
P
V
S
I
L
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
63.26
40%
-103
- C2 -
-
4ZY5
1
PAK1_HUMAN
A:
[20-278]
-------------
K
K
K
Y
T
R
F
------
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
------
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
---------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
Q
S
K
-
R
S
T
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.26
46%
-50
- C2 -
-
2XIK
2
STK25_HUMAN
A:
[27-283]
---------------------------
I
G
K
G
S
F
G
E
V
-
Y
K
G
I
D
N
H
T
K
E
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
--
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
---------
P
G
P
L
--
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
Q
G
---------
D
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
F
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
-----
H
P
M
-
R
V
L
F
L
I
----
P
K
N
S
--
P
P
T
L
E
G
---------
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
T
K
K
T
S
F
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
63.08
42%
-83
- C2 -
-
5J5T
1
M4K3_HUMAN
A:
[2-264]
------------
S
Q
E
D
F
E
L
I
Q
-----
R
I
G
S
G
T
Y
G
D
V
-
Y
K
A
R
N
V
N
T
G
E
-
L
--
A
A
I
K
V
I
-
K
L
E
P
G
E
--
D
--
F
A
V
----
V
Q
Q
E
I
I
M
-
M
K
D
-
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
------
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
--------
H
V
T
G
P
L
--
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
--
M
-
H
R
D
I
K
G
A
N
I
L
---
L
---
T
D
-
N
G
---------
H
---------
V
K
L
A
D
F
G
V
S
A
Q
I
T
--
A
T
I
A
-------
A
-
F
I
G
T
P
Y
W
M
A
P
E
-
V
AA
V
----
E
-
R
-
K
G
--
G
----
Y
N
Q
-
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
-----
H
P
M
-
R
A
L
F
L
M
----
T
K
S
N
FQ
P
P
K
L
----
K
D
K
---
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
62.60
40%
-77
- C2 -
-
5DEW
1
PAK1_HUMAN
B:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
-------------
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
62.52
40%
-65
- C2 -
-
4O0T
1
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
62.40
40%
-79
- C2 -
-
5DEY
1
PAK1_HUMAN
B:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
-------------
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.35
45%
-43
- C2 -
-
4QML
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
HHSearch
61.69
42%
-125
- C2 -
-
6AO5
1
STK3_HUMAN
A:
[13-268]
-----------------
D
V
L
E
-----
K
L
G
E
G
S
Y
G
S
V
-
F
K
A
I
H
------
V
--
V
A
I
K
Q
----------
D
--
L
Q
E
----
I
I
K
E
I
S
I
-
M
Q
Q
-
C
-
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
----------
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
-------
N
K
T
L
--
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
--
I
-
H
R
N
I
K
A
G
N
I
L
---
L
---
N
T
-
E
G
---------
H
---------
A
K
L
A
D
F
G
V
A
-------------------
V
I
G
T
P
F
W
M
A
P
E
-
V
--
I
----
Q
-
E
--
I
--
G
----
Y
N
C
-
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
-----
H
P
M
-
R
A
I
F
M
I
----
P
T
N
P
--
P
P
T
F
-------
R
K
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
-
I
K
N
-
A
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
61.62
45%
-40
- C2 -
-
4QMS
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
61.08
45%
-39
- C2 -
-
4QMO
3
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
60.81
45%
-40
- C2 -
-
4QMN
1
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
60.74
40%
-75
- C2 -
-
5IME
1
?
B:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
------
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
--------------
E
Q
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.59
45%
-40
- C2 -
-
4QMQ
3
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
60.33
41%
-73
- C2 -
-
4EQC
1
PAK1_HUMAN
A:
[26-281]
----------------
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
R
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
D
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.32
45%
-38
- C2 -
-
4QMP
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
59.98
45%
-37
- C2 -
-
4QMM
3
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
59.82
40%
-81
- C2 -
-
4P90
1
PAK1_HUMAN
B:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
----
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
-
N
L
-----------------
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
-----------------
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
59.80
44%
-50
- C2 -
-
4FZA
3
STK26_HUMAN
B:
[14-272]
--------------------
E
-----
R
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
Q
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
Q
G
---------
D
---------
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
Q
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-----
H
P
M
-
R
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
59.46
40%
-70
- C2 -
-
5DFP
2
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
R
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
D
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
59.41
38%
-89
- C2 -
-
2F57
1
PAK5_HUMAN
A:
[53-301]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
E
K
H
T
G
K
-
Q
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
S
-
D
G
---------
R
---------
I
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
K
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
V
--
I
----
S
-
R
-
L
---
P
----
Y
G
T
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
Q
A
M
R
R
I
----
R
D
S
L
--
P
P
R
----
V
K
D
---
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
-
L
K
L
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
59.24
40%
-71
- C2 -
-
3FXZ
1
?
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
R
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
D
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
58.67
44%
-57
- C2 -
-
4FZF
1
?
B:
[14-272]
--------------------
E
-----
R
I
G
K
G
--
G
E
V
-
F
K
G
I
D
N
R
T
Q
Q
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
Q
G
---------
D
---------
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
T
Q
I
K
R
N
T
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
Q
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-----
H
P
M
-
R
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
S
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
58.66
40%
-71
- C2 -
-
3FY0
1
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
R
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
D
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
58.33
40%
-78
- C2 -
-
4P90
1
PAK1_HUMAN
A:
[19-277]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
-------
E
--
V
A
I
K
Q
M
------------
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
---------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
------
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
57.86
40%
-70
- C2 -
-
3Q53
1
PAK1_HUMAN
A:
[20-278]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
R
Q
M
-
N
L
Q
Q
-
Q
-
P
K
--
K
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
D
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
------
Q
I
T
P
E
Q
S
-
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
57.41
38%
-91
- C2 -
-
5VEE
1
A:
[55-303]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
57.16
38%
-87
- C2 -
-
5UPK
1
?
B:
[82-330]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
57.12
38%
-86
- C2 -
-
5XVF
1
A:
[29-277]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
56.87
38%
-91
- C2 -
-
5I0B
1
PAK4_HUMAN
A:
[32-280]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
56.82
41%
3
- C2 -
-
6BDN
1
TAOK3_HUMAN
A:
[34-285]
---------------------------
I
G
H
G
S
F
G
A
V
-
Y
F
A
T
N
A
H
T
S
E
-
V
--
V
A
I
K
K
M
-
S
Y
S
G
K
Q
-
T
H
EK
W
Q
D
----
I
L
K
E
V
K
F
-
L
R
Q
-
L
-
K
H
P
N
T
I
E
Y
K
G
C
Y
L
K
E
------
H
T
A
W
L
V
M
E
Y
C
L
G
-
S
A
S
D
L
L
E
------
V
H
K
K
P
-
L
--
Q
E
V
E
I
A
A
I
T
H
G
A
L
H
G
L
A
Y
L
H
S
H
A
L
--
I
-
H
R
D
I
K
A
G
N
I
L
---
L
---
T
E
-
P
G
---------
Q
---------
V
K
L
A
D
F
G
-
S
A
S
M
A
S
P
A
N
---------
S
-
F
V
G
T
P
Y
W
M
A
P
E
-
V
--
I
----
L
-
A
-
M
D
EG
Q
----
Y
D
G
-
K
V
D
I
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
-----
N
A
M
-
S
A
L
Y
H
I
----
A
Q
N
D
--
S
P
T
L
Q
S
N
--------
E
W
T
D
S
F
R
R
F
V
D
Y
C
L
Q
K
I
P
Q
E
R
P
T
S
A
E
L
L
R
H
D
F
-
V
R
R
-
D
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
56.75
38%
-88
- C2 -
-
2X4Z
3
A:
[32-280]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
56.62
38%
-88
- C2 -
-
5ZJW
10
A:
[29-277]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
56.54
40%
-83
- C2 -
-
5KBR
1
PAK1_HUMAN
B:
[14-272]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
-----
G
T
V
-
Y
T
A
M
D
V
A
T
G
Q
-
E
--
V
A
I
K
Q
M
---------------------
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
-----------------
S
-
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
56.42
38%
-84
- C2 -
-
4FIF
1
PAK4_HUMAN
B:
[82-330]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
56.26
38%
-85
- C2 -
-
4FIF
1
PAK4_HUMAN
A:
[82-330]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
56.16
38%
-90
- C2 -
-
4NJD
1
A:
[32-280]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
55.99
38%
-85
- C2 -
-
4FIG
1
?
A:
[82-330]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
55.96
36%
-72
- C2 -
-
4KS7
2
A:
[31-285]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
L
A
R
E
K
H
S
G
R
-
Q
--
V
A
V
K
M
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
G
------
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
Q
V
R
---------
L
--
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
L
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
I
S
K
D
V
P
-
K
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
V
--
I
----
S
-
R
--
S
--
L
----
Y
A
T
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
-----
S
P
V
-
Q
A
M
K
R
L
----
R
D
S
P
--
P
P
K
L
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
L
Q
-
T
G
L
P
E
C
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
55.93
45%
-41
- C2 -
-
4QO9
4
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
55.90
38%
-84
- C2 -
-
5XVA
4
PAK4_HUMAN
A:
[29-277]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
55.90
38%
-83
- C2 -
-
5VED
1
PAK4_HUMAN
A:
[55-303]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
55.79
45%
-40
- C2 -
-
4QO9
4
STK24_HUMAN
B:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
55.75
38%
-83
- C2 -
-
5XVG
7
A:
[29-277]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
55.74
45%
-43
- C2 -
-
4QMZ
1
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
55.68
38%
-86
- C2 -
-
4FIE
1
PAK4_HUMAN
B:
[159-407]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
55.67
45%
-42
- C2 -
-
4U8Z
1
STK24_HUMAN
A:
[20-278]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
55.63
45%
-39
- C2 -
-
4QMW
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
55.61
38%
-85
- C2 -
-
4FIE
1
PAK4_HUMAN
A:
[159-407]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
55.59
45%
-41
- C2 -
-
4QMT
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
55.58
38%
-80
- C2 -
-
4FIG
1
?
B:
[82-330]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
55.43
45%
-40
- C2 -
-
4W8D
1
STK24_HUMAN
A:
[20-278]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
55.40
38%
-86
- C2 -
-
2J0I
4
A:
[39-287]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
55.37
45%
-40
- C2 -
-
4QMY
2
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
55.29
38%
-82
- C2 -
-
4APP
2
A:
[32-280]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
55.28
45%
-39
- C2 -
-
4QMX
1
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
55.18
45%
-38
- C2 -
-
4W8E
1
STK24_HUMAN
A:
[20-278]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
55.17
38%
-81
- C2 -
-
5VEF
1
?
A:
[55-303]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
55.16
45%
-43
- C2 -
-
3CKX
1
STK24_HUMAN
A:
[13-271]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
--
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
55.14
45%
-38
- C2 -
-
3A7H
1
STK24_HUMAN
B:
[28-286]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
54.95
38%
-82
- C2 -
-
4JDI
1
PAK4_HUMAN
A:
[82-330]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
54.78
40%
-72
- C2 -
-
5KBR
1
PAK1_HUMAN
A:
[14-272]
-------------
K
K
K
Y
T
R
F
E
-----
K
I
G
Q
G
A
S
G
T
V
-
Y
T
A
--------
E
--
V
A
I
K
Q
--------------
E
L
----
I
I
N
E
I
L
V
-
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
------------
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
---------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
--
I
-
H
R
N
I
K
S
D
N
I
L
---
L
---
G
M
-
D
G
---------
S
---------
V
K
L
T
D
F
G
F
C
A
--------------
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
-
V
--
V
----
T
-
R
--
K
--
A
----
Y
G
P
-
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-----
N
P
L
-
R
A
L
Y
L
I
----
A
T
N
G
--
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
-
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
54.65
38%
-81
- C2 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[102-350]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
54.33
45%
-39
- C2 -
-
4QMV
3
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
54.32
38%
-79
- C2 -
-
2Q0N
7
A:
[37-285]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
54.28
38%
-86
- C2 -
-
5BMS
1
A:
[29-277]
---------------------------
I
G
E
G
S
T
G
I
V
-
C
I
A
T
V
R
S
S
G
K
-
L
--
V
A
V
K
K
M
-
D
L
R
K
-
Q
-
Q
R
--
R
E
L
----
L
F
N
E
V
V
I
-
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
---------
M
--
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
--
I
-
H
R
D
I
K
S
D
S
I
L
---
L
---
T
H
-
D
G
---------
R
---------
V
K
L
S
D
F
G
F
C
A
------
Q
V
S
K
E
V
P
-
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
-
L
--
I
----
S
-
R
-
L
---
P
----
Y
G
P
-
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-----
P
P
L
-
K
A
M
K
M
I
----
R
D
N
L
--
P
P
R
L
K
N
-------
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
54.15
45%
-36
- C2 -
-
4QNA
1
STK24_HUMAN
A:
[35-293]
--------------------
E
-----
K
I
G
K
G
S
F
G
E
V
-
F
K
G
I
D
N
R
T
Q
K
-
V
--
V
A
I
K
I
I
-
D
L
E
E
A
E
-
D
E
--
I
E
D
----
I
Q
Q
E
I
T
V
-
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
--
I
-
H
R
D
I
K
A
A
N
V
L
---
L
---
S
E
-
H
G
---------
E
---------
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
T
Q
I
-
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
-
V
--
I
----
K
-
Q
--
S
--
A
----
Y
D
S
-
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-----
H
P
M
-
K
V
L
F
L
I
----
P
K
N
N
--
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-
A
K
K
T
S
Y
L
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
53.58
38%
-16
- C2 -
-
4OBQ
2
M4K4_HUMAN
A:
[26-296]
----------------
F
E
L
V
E
-----
V
V
G
N
G
T
Y
G
Q
V
-
Y
K
G
R
H
V
K
T
G
Q
-
L
--
A
A
I
K
V
M
-
D
V
-------------------
E
I
N
M
-
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPGHD
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
T
------
K
G
N
T
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
--
I
-
H
R
D
I
K
G
Q
N
V
L
---
L
---
T
E
-
N
A
---------
E
---------
V
K
L
V
D
F
G
V
-----------------
N
T
-
F
I
G
T
P
Y
W
M
A
P
E
-
V
--
I
----
A
-
C
-
D
E
--
N
PDAT
Y
D
Y
-
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-----
H
P
M
-
R
A
L
F
L
I
----
P
R
N
P
--
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
-
Q
P
N
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
53.10
38%
-4
- C2 -
-
6RA7
2
?
A:
[17-287]
----------------
F
E
L
V
E
-----
L
V
G
N
G
T
Y
G
Q
V
-
Y
K
G
R
H
V
K
T
G
Q
-
L
--
A
A
I
K
V
M
-
D
V
T
G
D
E
-
E
----
E
E
----
I
K
Q
E
I
N
M
-
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
NPPGMD
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
V
T
D
L
I
K
N
T
------
K
G
N
T
L
--
K
E
E
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
H
K
V
--
I
-
H
R
D
I
K
G
Q
N
V
L
---
L
---
T
E
-
N
A
---------
E
---------
V
K
L
V
D
F
G
V
S
A
Q
L
D
R
V
G
--------
R
R
N
-
F
I
G
T
P
Y
W
M
A
P
E
-
V
--
I
----
A
-
C
-
D
E
--
N
PDAT
Y
D
F
-
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-----
H
P
M
-
R
A
L
F
L
I
----
P
R
N
P
--
A
P
R
L
K
S
--------
K
K
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
R
P
A
T
E
Q
L
M
K
H
P
F
-
I
R
D
-
Q
P
N
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
53.00
39%
-45
- C2 -
-
5DH3
1
STK3_HUMAN
A:
[29-291]
----------------
F
D
V
L
E
-----
K
L
G
E
G
S
Y
G
S
V
-
F
K
A
I
H
K
E
S
G
Q
-
V
--
V
A
I
K
Q
V
-
P
V
E
----
S
D
--
L
Q
E
----
I
I
K
E
I
S
I
-
M
Q
Q
-
C
-
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
------
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
-------
R
N
K
T
L
--
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
--
I
-
H
R
D
I
K
A
G
N
I
L
---
L
---
N
T
-
E
G
---------
H
---------
A
K
L
A
D
F
G
V
A
------
G
Q
L
T
-
D
M
A
-
K
R
N
-
V
I
G
T
P
F
W
M
A
P
E
-
V
--
I
----
Q
-
E
-
I
---
G
----
Y
N
C
-
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
-----
H
P
M
-
R
A
I
F
M
I
----
P
T
N
P
--
P
P
T
F
----
R
K
P
E
L
---
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
-
I
K
N
-
A
K
P
V
S
I
L
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
52.83
32%
-70
- C2 -
-
4FG8
1
KCC1A_HUMAN
B:
[17-273]
-------------
R
D
I
Y
D
F
R
D
-----
V
L
G
T
G
A
F
S
E
V
-
I
L
A
E
D
K
R
T
Q
K
-
L
--
V
A
I
K
C
I
-
A
K
------------------
N
E
I
A
V
-
L
H
K
-
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
---
R
I
V
E
K
G
F
Y
T
-------
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
--
V
-
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
-
D
S
---------
K
---------
I
M
I
S
D
F
G
-------
G
S
------
V
-
L
S
T
-
A
C
G
T
P
G
Y
V
A
P
E
-
V
--
L
----
A
-
Q
--
K
--
P
----
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-----
N
D
A
-
K
L
F
E
Q
I
----
L
K
A
E
--
Y
E
F
------
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
52.73
32%
-72
- C2 -
-
4FG9
1
KCC1A_HUMAN
B:
[17-273]
-------------
R
D
I
Y
D
F
R
D
-----
V
L
G
T
G
A
F
S
E
V
-
I
L
A
E
D
K
R
T
Q
K
-
L
--
V
A
I
K
C
I
-
A
K
-------------------
E
I
A
V
-
L
H
K
-
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
---
R
I
V
E
K
G
F
Y
T
-------
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
--
V
-
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
-
D
S
---------
K
---------
I
M
I
S
D
F
----------------
V
-
L
S
T
-
A
C
G
T
P
G
Y
V
A
P
E
-
V
--
L
----
A
-
Q
--
K
--
P
----
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-----
N
D
A
-
K
L
F
E
Q
I
----
L
K
A
E
--
Y
E
F
------
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
52.29
32%
-73
- C2 -
-
4FG8
1
KCC1A_HUMAN
A:
[17-273]
-------------
R
D
I
Y
D
F
R
D
-----
V
L
G
T
G
A
F
S
E
V
-
I
L
A
E
D
K
R
T
Q
K
-
L
--
V
A
I
K
C
I
-
A
K
-----------------
E
N
E
I
A
V
-
L
H
K
-
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
---
R
I
V
E
K
G
F
Y
T
-------
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
--
V
-
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
-
D
S
---------
K
---------
I
M
I
S
D
F
-------------------------
T
P
G
Y
V
A
P
E
-
V
--
L
----
A
-
Q
--
K
--
P
----
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-----
N
D
A
-
K
L
F
E
Q
I
----
L
K
A
E
--
Y
E
F
------
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
52.11
39%
-45
- C2 -
-
5DH3
1
STK3_HUMAN
B:
[29-291]
----------------
F
D
V
L
E
-----
K
L
G
E
G
S
Y
G
S
V
-
F
K
A
I
H
K
E
S
G
Q
-
V
--
V
A
I
K
Q
V
-
P
V
E
----
S
D
--
L
Q
E
----
I
I
K
E
I
S
I
-
M
Q
Q
-
C
-
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
------
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
-------
R
N
K
T
L
--
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
--
I
-
H
R
D
I
K
A
G
N
I
L
---
L
---
N
T
-
E
G
---------
H
---------
A
K
L
A
D
F
G
V
A
------
G
Q
L
T
-
D
M
A
-
K
R
N
-
V
I
G
T
P
F
W
M
A
P
E
-
V
--
I
----
Q
-
E
-
I
---
G
----
Y
N
C
-
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
-----
H
P
M
-
R
A
I
F
M
I
----
P
T
N
P
--
P
P
T
F
----
R
K
P
E
L
---
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
-
I
K
N
-
A
K
P
V
S
I
L
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
52.07
32%
-71
- C2 -
-
4FG7
1
KCC1A_HUMAN
A:
[17-273]
-------------
R
D
I
Y
D
F
R
D
-----
V
L
G
T
G
A
F
S
E
V
-
I
L
A
E
D
K
R
T
Q
K
-
L
--
V
A
I
K
C
I
-
A
------------
S
----
M
E
N
E
I
A
V
-
L
H
K
-
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
---
R
I
V
E
K
G
F
Y
T
-------
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
--
V
-
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
-
D
S
---------
K
---------
I
M
I
S
D
F
G
L
S
K
M
E
D
P
----------------
G
T
P
G
Y
V
A
P
E
-
V
--
L
----
A
-
Q
--
K
--------
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-----
N
D
A
-
K
L
F
E
Q
I
----
L
K
A
E
--
Y
E
F
------
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
51.98
32%
-73
- C2 -
-
4FG9
1
KCC1A_HUMAN
A:
[17-273]
-------------
R
D
I
Y
D
F
R
D
-----
V
L
G
T
G
A
F
S
E
V
-
I
L
A
E
D
K
R
T
Q
K
-
L
--
V
A
I
K
C
I
-
A
K
E
----------------
E
N
E
I
A
V
-
L
H
K
-
I
-
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
---
R
I
V
E
K
G
F
Y
T
-------
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
--
V
-
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
-
D
S
---------
K
---------
I
M
I
S
D
F
--------------------------
P
G
Y
V
A
P
E
-
V
--
L
----
A
-
Q
--
K
--
P
----
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-----
N
D
A
-
K
L
F
E
Q
I
----
L
K
A
E
--
Y
E
F
------
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
50.57
31%
-129
- C2 -
-
4A4O
2
PLK1_HUMAN
A:
[67-271]
-------------------------------------------------------------------------------
E
I
S
I
-
H
R
S
-
L
-
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
------
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
--------
R
R
K
A
L
--
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
--
I
-
H
R
D
L
K
L
G
N
L
F
---
L
---
N
E
-
D
L
---------
E
---------
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
-----
R
-
K
K
T
-
L
C
G
T
P
N
Y
I
A
P
E
-
V
--
L
----
S
-
K
--
K
--
G
----
H
S
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
-
E
T
-----
S
C
L
-
K
E
T
Y
L
R
----
I
K
K
N
--
E
Y
S
I
P
K
H
I
N
P
V
A
A
---------
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
-
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
49.67
37%
-8
- C2 -
-
1U5R
1
TAOK2_RAT
A:
[62-308]
---------------------------
I
G
H
G
S
F
G
A
V
-
Y
F
A
R
D
V
R
N
S
E
-
V
--
V
A
I
K
K
M
-
S
Y
S
G
K
Q
-
S
N
EK
W
Q
D
----
I
I
K
E
V
R
F
-
L
Q
K
-
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
------
H
T
A
W
L
V
M
E
Y
C
L
G
-
S
A
S
D
L
L
E
------
V
H
K
K
P
-
L
--
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
S
E
-
P
G
---------
L
---------
V
K
L
G
D
F
G
S
A
S
I
M
A
P
A
-----------
N
-
F
V
G
T
P
Y
W
M
A
P
E
-
V
--
I
----
L
-
A
-
M
D
EG
Q
----
Y
D
G
-
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
-----
N
A
M
-
S
A
L
Y
H
I
----
A
Q
N
E
--
S
P
A
L
Q
S
G
--------
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
48.23
37%
-10
- C2 -
-
2GCD
1
TAOK2_RAT
B:
[23-269]
---------------------------
I
G
H
G
S
F
G
A
V
-
Y
F
A
R
D
V
R
N
S
E
-
V
--
V
A
I
K
K
M
-
S
Y
S
G
K
Q
-
S
N
EK
W
Q
D
----
I
I
K
E
V
R
F
-
L
Q
K
-
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
------
H
T
A
W
L
V
M
E
Y
C
L
G
-
S
A
S
D
L
L
E
------
V
H
K
K
P
-
L
--
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
S
E
-
P
G
---------
L
---------
V
K
L
G
D
F
G
S
A
S
I
M
A
P
A
-----------
N
-
F
V
G
T
P
Y
W
M
A
P
E
-
V
--
I
----
L
-
A
-
M
D
EG
Q
----
Y
D
G
-
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
-----
N
A
M
-
S
A
L
Y
H
I
----
A
Q
N
E
--
S
P
A
L
Q
S
G
--------
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
48.13
31%
-32
- C2 -
-
3ALN
1
MP2K4_HUMAN
A:
[17-288]
---------
W
D
F
T
A
E
D
L
K
D
L
G
-----
E
I
G
R
G
A
Y
G
S
V
-
N
K
M
V
H
K
P
S
G
Q
-
I
--
M
A
V
K
R
I
-
R
S
T
V
D
E
-
K
E
--
Q
K
Q
----
L
L
M
D
L
D
V
V
M
R
S
-
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
------
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
---
D
V
I
--
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
--
I
I
H
R
D
I
K
P
S
N
I
L
---
L
---
D
R
-
S
G
---------
N
---------
I
K
L
C
D
F
G
I
S
G
Q
--------------------------------------------------
Y
D
V
-
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
------------
T
Q
V
----
V
K
G
D
--
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
47.68
37%
-7
- C2 -
-
1U5R
1
TAOK2_RAT
B:
[62-308]
---------------------------
I
G
H
G
S
F
G
A
V
-
Y
F
A
R
D
V
R
N
S
E
-
V
--
V
A
I
K
K
M
-
S
Y
S
G
K
Q
-
S
N
EK
W
Q
D
----
I
I
K
E
V
R
F
-
L
Q
K
-
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
------
H
T
A
W
L
V
M
E
Y
C
L
G
-
S
A
S
D
L
L
E
------
V
H
K
K
P
-
L
--
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
S
E
-
P
G
---------
L
---------
V
K
L
G
D
F
G
S
A
S
I
M
A
P
A
-----------
N
-
F
V
G
T
P
Y
W
M
A
P
E
-
V
--
I
----
L
-
A
-
M
D
EG
Q
----
Y
D
G
-
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
-----
N
A
M
-
S
A
L
Y
H
I
----
A
Q
N
E
--
S
P
A
L
Q
S
G
--------
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
47.62
36%
29
- C2 -
-
6EIM
5
STK10_HUMAN
A:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
-------
K
V
Y
K
A
K
N
K
E
-
T
GA
L
A
A
A
K
V
-
I
E
T
K
S
E
-
E
E
--
L
E
D
----
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
--
I
-
H
R
D
L
K
A
G
N
V
L
---
M
---
T
L
-
E
G
---------
D
---------
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
L
Q
K
-
R
D
S
-
F
I
G
T
P
Y
W
M
A
P
E
-
V
--
V
MC--
E
-
T
-
M
K
--
D
TP--
Y
D
Y
-
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
L
L
A
I
----
A
A
S
D
--
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
A
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
47.49
37%
-6
- C2 -
-
2GCD
1
TAOK2_RAT
A:
[23-269]
---------------------------
I
G
H
G
S
F
G
A
V
-
Y
F
A
R
D
V
R
N
S
E
-
V
--
V
A
I
K
K
M
-
S
Y
S
G
K
Q
-
S
N
EK
W
Q
D
----
I
I
K
E
V
R
F
-
L
Q
K
-
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
------
H
T
A
W
L
V
M
E
Y
C
L
G
-
S
A
S
D
L
L
E
------
V
H
K
K
P
-
L
--
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
--
I
-
H
R
D
V
K
A
G
N
I
L
---
L
---
S
E
-
P
G
---------
L
---------
V
K
L
G
D
F
G
S
A
S
I
M
A
P
A
-----------
N
-
F
V
G
T
P
Y
W
M
A
P
E
-
V
--
I
----
L
-
A
-
M
D
EG
Q
----
Y
D
G
-
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
-----
N
A
M
-
S
A
L
Y
H
I
----
A
Q
N
E
--
S
P
A
L
Q
S
G
--------
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
47.17
34%
9
- C2 -
-
5V24
1
B:
[5-270]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
-
Y
A
G
R
D
L
S
N
Q
V
-
R
--
I
A
I
K
E
I
-
P
-
E
R
D
S
-
R
Y
--
S
Q
P
----
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
--
V
-
H
R
D
I
K
G
D
N
V
L
---
I
---
N
T
Y
S
G
---------
V
---------
L
K
I
S
D
F
G
T
S
K
R
L
--------------
T
-
F
T
G
T
L
Q
Y
M
A
P
E
-
I
--
I
----
D
-
K
G
P
R
--
G
----
Y
G
K
-
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GEPQA
A
M
F
-
K
V
G
M
F
K
----
V
H
P
E
--
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
46.86
31%
-9
- C2 -
-
3ALO
1
MP2K4_HUMAN
A:
[17-288]
---------
W
D
F
T
A
E
D
L
K
D
L
G
-----
E
I
G
R
G
A
Y
G
S
V
-
N
K
M
V
H
K
P
S
G
Q
-
I
--
M
A
V
K
R
I
-
R
S
T
V
D
E
-
K
E
--
Q
K
Q
----
L
L
M
D
L
D
V
V
M
R
S
-
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
------
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
---
D
V
I
--
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
--
I
I
H
R
D
I
K
P
S
N
I
L
---
L
---
D
R
-
S
G
---------
N
---------
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
A
K
T
R
D
--------
A
G
C
R
P
Y
M
A
P
E
-
R
--
I
----
D
P-----------
Y
D
V
-
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
-----
N
S
V
F
D
Q
L
T
Q
V
----
V
K
G
D
--
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
45.96
33%
6
- C2 -
-
4BIE
2
M3K5_HUMAN
A:
[15-281]
---------------
D
Y
E
Y
D
E
NGDRV
V
L
G
K
G
T
Y
G
I
V
-
Y
A
G
R
D
L
S
N
Q
V
-
R
--
I
A
I
K
E
I
-
P
-
E
---------------
L
H
E
E
I
A
L
-
H
K
H
-
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
S
-------
K
W
G
P
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
--
V
-
H
R
D
I
K
G
D
N
V
L
---
I
---
N
T
Y
S
G
---------
V
---------
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
-------
E
-
F
T
G
T
L
Q
Y
M
A
P
E
-
I
--
I
----
D
-
K
G
P
R
--
G
----
Y
G
K
-
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
GEPQA
A
M
F
-
K
V
G
M
F
K
----
V
H
P
E
--
I
P
---------
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
45.27
35%
12
- C2 -
-
2JFL
6
SLK_HUMAN
A:
[33-303]
-----------
L
N
P
E
D
F
--
W
E
-----
I
I
G
E
L
G
D
G
A
F
-
G
K
V
Y
K
A
Q
N
K
E
-
T
SV
L
A
A
A
K
V
-
I
D
T
K
S
E
-
E
E
--
L
E
D
----
Y
M
V
E
I
D
I
-
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
-------
E
R
P
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
--
I
-
H
R
D
L
K
A
G
N
I
L
---
F
---
T
L
-
D
G
---------
D
---------
I
K
L
A
D
F
G
V
S
A
------
K
N
T
R
I
Q
--
R
R
D
-
F
I
G
T
P
Y
W
M
A
P
E
-
V
--
V
MCET
S
-
K
-
D
R
--
P
----
Y
D
Y
-
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
L
L
K
I
----
A
K
S
E
--
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
-
D
S
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
45.10
31%
3
- C2 -
-
3HZT
9
?
A:
[4-292]
--------------
D
R
Y
Q
R
V
K
-----
K
L
G
S
G
A
Y
G
E
V
-
L
L
C
K
D
K
L
T
G
A
-
E
--
R
A
I
K
I
I
-
K
K
S
S
V
T
-
T
T
--
S
N
S
GA--
L
L
D
E
V
A
V
-
L
K
Q
-
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
------
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
---
E
I
I
L
R
Q
K
-----
F
--
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
--
V
-
H
R
D
L
K
P
E
N
L
L
---
L
ESK
S
R
-
D
A
---------
L
---------
I
K
I
V
D
F
G
L
S
A
H
F
E
V
----------------
G
T
A
Y
Y
I
A
P
E
-
V
--
L
----
R
----
K
--
K
----
Y
D
E
-
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
-----
T
D
Q
-
E
I
L
K
R
V
EKGK
F
S
F
D
--
P
P
D
W
-
T
Q
V
S
D
E
A
---------
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
45.08
31%
-25
- C2 -
-
3ALN
1
MP2K4_HUMAN
B:
[17-288]
---------
W
D
F
T
A
E
D
L
K
D
L
G
-----
E
I
G
R
G
A
Y
G
S
V
-
N
K
M
V
H
K
P
S
G
Q
-
I
--
M
A
V
K
R
I
-
R
S
T
V
D
E
-
K
E
--
Q
K
Q
----
L
L
M
D
L
D
V
V
M
R
S
-
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
------
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
L
D
---
D
V
I
--
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
--
I
I
H
R
D
I
K
P
S
N
I
L
---
L
---
D
R
-
S
G
---------
N
---------
I
K
L
C
D
F
G
I
S
G
Q
L
-------------------------------------------------
Y
D
V
-
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
------------------------
D
--
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
45.02
36%
6
* C2 *
-
6HXF
2
STK10_HUMAN
C:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
D
G
A
F
-
G
K
V
Y
K
A
K
N
K
E
-
T
GA
L
A
A
A
K
V
-
I
E
T
K
-
E
-
E
E
--
L
E
D
----
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
--
I
-
H
R
D
L
K
A
G
N
V
L
---
M
---
T
L
-
E
G
---------
D
---------
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
L
Q
K
---
R
D
-
F
I
G
T
P
Y
W
M
A
P
E
V
V
--
M
----
C
-
E
-
M
K
--
D
TP--
Y
D
Y
-
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
L
L
K
I
----
A
K
S
D
--
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
44.61
31%
-65
- C2 -
-
4YFI
1
D:
[56-270]
---------
F
H
L
Q
L
S
E
I
E
F
H
E
-----
I
I
G
S
G
S
F
G
K
V
-
Y
K
G
R
C
--
R
N
K
-
I
--
V
A
I
K
R
Y
--------
S
D
--
V
D
M
----
F
C
R
E
V
S
I
-
L
C
Q
-
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
L
N
D
P-----
S
Q
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
Q
K
R
I
L
--
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
N
L
T
Q
PI
I
-
H
R
D
L
N
S
H
N
I
L
---
L
---
Y
E
-
D
G
---------
H
---------
A
V
V
A
D
F
G
E
S
R
F
L
Q
S
----------------
G
N
L
R
W
M
A
P
E
-
V
--
F
----
T
-
Q
-
C
T
--
R
----
Y
T
I
-
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
G
E
I
P
F
A
H
L
-----
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
43.95
31%
-61
- C2 -
-
4YFF
1
TNI3K_HUMAN
C:
[37-251]
---------
F
H
L
Q
L
S
E
I
E
F
H
E
-----
I
I
G
S
G
S
F
G
K
V
-
Y
K
G
R
C
--
R
N
K
-
I
--
V
A
I
K
R
Y
--------
S
D
--
V
D
M
----
F
C
R
E
V
S
I
-
L
C
Q
-
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
L
N
D
P-----
S
Q
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
Q
K
R
I
L
--
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
N
L
T
Q
PI
I
-
H
R
D
L
N
S
H
N
I
L
---
L
---
Y
E
-
D
G
---------
H
---------
A
V
V
A
D
F
G
E
S
R
F
L
Q
S
--------
Q
-
P
-----
G
N
L
R
W
M
A
P
E
-
V
--
F
----
T
-
Q
-
C
T
--
R
----
Y
T
I
-
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
G
E
I
P
F
A
H
L
-----
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
43.54
31%
-63
- C2 -
-
6B5J
1
D:
[37-251]
---------
F
H
L
Q
L
S
E
I
E
F
H
E
-----
I
I
G
S
G
S
F
G
K
V
-
Y
K
G
R
C
--
R
N
K
-
I
--
V
A
I
K
R
Y
--------
S
D
--
V
D
M
----
F
C
R
E
V
S
I
-
L
C
Q
-
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
L
N
D
P-----
S
Q
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
Q
K
R
I
L
--
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
N
L
T
Q
PI
I
-
H
R
D
L
N
S
H
N
I
L
---
L
---
Y
E
-
D
G
---------
H
---------
A
V
V
A
D
F
G
E
S
R
F
L
Q
S
----------------
G
N
L
R
W
M
A
P
E
-
V
--
F
----
T
-
Q
-
C
T
--
R
----
Y
T
I
-
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
G
E
I
P
F
A
H
L
-----
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
43.28
33%
-83
- C2 -
-
5EAK
1
MARK2_HUMAN
B:
[16-214]
---------------
N
Y
R
L
L
K
-----
T
I
G
K
G
N
F
A
K
V
-
K
L
A
R
H
I
L
T
G
K
-
E
--
V
A
V
K
I
I
-
D
K
T
Q
L
N
-
S
S
S-
L
Q
K
----
L
F
R
E
V
R
I
-
M
K
V
-
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
------
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
---
Y
L
V
A
H
G
R
M
K
-------
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
--
V
-
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
-
D
M
---------
N
---------
I
K
I
A
D
F
G
---------------------
F
C
G
S
P
P
Y
A
A
P
E
-
L
--
F
------
Q
-
G
K
--
K
----
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
42.96
32%
-73
- C2 -
-
6QAU
4
ULK2_HUMAN
C:
[12-273]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
----------
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
N
RRKSSVSGI
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
H
S
-----------------
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
42.90
31%
-59
- C2 -
-
4YFF
1
D:
[37-251]
---------
F
H
L
Q
L
S
E
I
E
F
H
E
-----
I
I
G
S
G
S
F
G
K
V
-
Y
K
G
R
C
--
R
N
K
-
I
--
V
A
I
K
R
Y
--------
S
D
--
V
D
M
----
F
C
R
E
V
S
I
-
L
C
Q
-
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
L
N
D
P-----
S
Q
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
Q
K
R
I
L
--
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
N
L
T
Q
PI
I
-
H
R
D
L
N
S
H
N
I
L
---
L
---
Y
E
-
D
G
---------
H
---------
A
V
V
A
D
F
G
E
S
R
F
L
Q
S
----------------
G
N
L
R
W
M
A
P
E
-
V
--
F
----
T
-
Q
-
C
T
--
R
----
Y
T
I
-
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
G
E
I
P
F
A
H
L
-----
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
42.89
36%
11
- C2 -
-
6HXF
5
STK10_HUMAN
B:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
D
G
A
F
-
G
K
V
Y
K
A
K
N
K
E
-
T
GA
L
A
A
A
K
V
-
I
E
T
K
S
E
-
E
E
--
L
E
D
----
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
--
I
-
H
R
D
L
K
A
G
N
V
L
---
M
---
T
L
-
E
G
---------
D
---------
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
L
Q
K
---
R
D
-
F
I
G
T
P
Y
W
M
A
P
E
V
V
--
M
----
C
-
E
-
M
K
--
D
TP--
Y
D
Y
-
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
L
L
K
I
----
A
K
S
D
--
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
42.62
31%
-41
- C2 -
-
4YFI
1
TNI3K_HUMAN
A:
[56-270]
---------
F
H
L
Q
L
S
E
I
E
F
H
E
-----
I
I
G
S
G
S
F
G
K
V
-
Y
K
G
R
C
--
R
N
K
-
I
--
V
A
I
K
R
Y
R-------
S
D
--
V
D
M
----
F
C
R
E
V
S
I
-
L
C
Q
-
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
L
N
D
P-----
S
Q
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
Q
K
R
I
L
--
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
N
L
T
Q
PI
I
-
H
R
D
L
N
S
H
N
I
L
---
L
---
Y
E
-
D
G
---------
H
---------
A
V
V
A
D
F
G
E
S
R
F
L
Q
-----------------
G
N
L
R
W
M
A
P
E
-
V
--
F
----
T
-
Q
-
C
T
--
R
----
Y
T
I
-
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
G
E
I
P
F
A
H
L
-----
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
42.05
32%
-81
- C2 -
-
6QAT
1
ULK2_HUMAN
B:
[12-278]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
K
N
L
S
-
K
S
--
Q
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
N
VSGI-----
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
H
------------------
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
42.05
33%
-76
- C2 -
-
5EAK
1
MARK2_HUMAN
A:
[16-214]
---------------
N
Y
R
L
L
K
-----
T
I
G
K
G
N
F
A
K
V
-
K
L
A
R
H
I
L
T
G
K
-
E
--
V
A
V
K
I
I
-
D
K
T
Q
L
N
-
S
S
S-
L
Q
K
----
L
F
R
E
V
R
I
-
M
K
V
-
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
------
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
---
Y
L
V
A
H
G
R
M
K
-------
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
--
V
-
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
-
D
M
---------
N
---------
I
K
I
A
D
F
G
F
S
-------------------
F
C
G
S
P
P
Y
A
A
P
E
-
L
--
F
------
Q
-
G
K
--
K
----
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
41.98
32%
-88
- C2 -
-
6QAT
1
ULK2_HUMAN
D:
[12-233]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
K
N
L
S
-
K
S
--
Q
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
-VSGI-----
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
--------------------
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
41.96
32%
-77
- C2 -
-
6QAU
4
ULK2_HUMAN
B:
[12-233]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
K
N
L
S
-
K
S
--
Q
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
N
RRKSSVSGI
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
H
------------------
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
41.86
31%
-32
- C2 -
-
4YFI
1
TNI3K_HUMAN
B:
[56-270]
---------
F
H
L
Q
L
S
E
I
E
F
H
E
-----
I
I
G
S
G
S
F
G
K
V
-
Y
K
G
R
C
--
R
N
K
-
I
--
V
A
I
K
R
Y
R-------
S
D
--
V
D
M
----
F
C
R
E
V
S
I
-
L
C
Q
-
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
L
N
D
P-----
S
Q
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
Q
K
R
I
L
--
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
N
L
T
Q
PI
I
-
H
R
D
L
N
S
H
N
I
L
---
L
---
Y
E
-
D
G
---------
H
---------
A
V
V
A
D
F
G
E
S
R
F
L
Q
S
----------------
G
N
L
R
W
M
A
P
E
-
V
--
F
----
T
-
Q
-
C
T
--
R
----
Y
T
I
-
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
G
E
I
P
F
A
H
L
-----
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
41.73
33%
-77
- C2 -
-
5KZ8
1
MARK2_HUMAN
A:
[34-232]
---------------
N
Y
R
L
L
K
-----
T
I
G
K
G
N
F
A
K
V
-
K
L
A
R
H
I
L
T
G
K
-
E
--
V
A
V
K
I
I
-
D
K
T
Q
L
N
-
S
S
S-
L
Q
K
----
L
F
R
E
V
R
I
-
M
K
V
-
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
------
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
---
Y
L
V
A
H
G
R
M
K
-------
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
--
V
-
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
-
D
M
---------
N
---------
I
K
I
A
D
F
G
----------------------
C
G
S
P
P
Y
A
A
P
E
-
L
--
F
------
Q
-
G
K
--
K
----
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
41.63
31%
-45
- C2 -
-
4YFF
1
TNI3K_HUMAN
A:
[37-251]
---------
F
H
L
Q
L
S
E
I
E
F
H
E
-----
I
I
G
S
G
S
F
G
K
V
-
Y
K
G
R
C
--
R
N
K
-
I
--
V
A
I
K
R
Y
R-------
S
D
--
V
D
M
----
F
C
R
E
V
S
I
-
L
C
Q
-
L
-
N
H
P
C
V
I
Q
F
V
G
A
C
L
N
D
P-----
S
Q
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
-------
H
E
Q
K
R
I
L
--
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
N
L
T
Q
PI
I
-
H
R
D
L
N
S
H
N
I
L
---
L
---
Y
E
-
D
G
---------
H
---------
A
V
V
A
D
F
G
E
S
R
F
L
Q
S
-----------------
N
L
R
W
M
A
P
E
-
V
--
F
----
T
-
Q
-
C
T
--
R
----
Y
T
I
-
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
G
E
I
P
F
A
H
L
-----
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
41.62
31%
-55
- C2 -
-
4WNP
2
ULK1_HUMAN
B:
[14-240]
----------
T
V
G
K
F
E
F
S
R
K
D
-----
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
--
V
A
V
K
C
I
-
N
K
K
N
L
A
-
K
S
--
Q
T
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
A
------
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
--------
H
A
M
R
T
L
--
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
N
-
P
A
---------
G
RRANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
-------
Q
S
N
M
-
M
A
A
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
-----
S
P
Q
-
D
L
R
L
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
41.41
33%
-71
- C2 -
-
5ES1
1
MARK4_HUMAN
A:
[16-214]
---------------
N
Y
R
L
L
R
-----
T
I
G
K
G
N
F
A
K
V
-
K
L
A
R
H
I
L
T
G
R
-
E
--
V
A
I
K
I
I
-
D
K
T
Q
L
N
P
S
S
--
L
Q
K
----
L
F
R
E
V
R
I
-
M
K
G
-
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
------
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
---
Y
L
V
S
H
G
R
M
K
-------
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
--
V
-
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
-
E
A
---------
N
---------
I
K
I
A
D
F
G
F
S
N
---------------------
S
P
P
Y
A
A
P
E
-
L
--
F
------
Q
-
G
K
--
K
----
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
41.19
32%
-84
- C2 -
-
6QAT
1
ULK2_HUMAN
A:
[12-233]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
K
N
L
S
-
K
S
--
Q
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
N
VSGI-----
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
H
------------------
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
41.09
31%
-53
- C2 -
-
4WNO
1
ULK1_HUMAN
A:
[14-240]
----------
T
V
G
K
F
E
F
S
R
K
D
-----
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
--
V
A
V
K
C
I
-
N
K
K
N
L
A
-
K
S
--
Q
T
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
A
------
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
--------
H
A
M
R
T
L
--
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
N
-
P
A
---------
G
RRANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
-------
Q
S
N
M
-
M
A
A
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
-----
S
P
Q
-
D
L
R
L
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
41.05
33%
-65
- C2 -
-
5KZ8
1
MARK2_HUMAN
B:
[34-232]
---------------
N
Y
R
L
L
K
-----
T
I
G
K
G
N
F
A
K
V
-
K
L
A
R
H
I
L
T
G
K
-
E
--
V
A
V
K
I
I
-
D
K
T
Q
L
N
-
S
S
S-
L
Q
K
----
L
F
R
E
V
R
I
-
M
K
V
-
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
------
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
---
Y
L
V
A
H
G
R
M
K
-------
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
--
V
-
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
-
D
M
---------
N
---------
I
K
I
A
D
F
------------------------
G
S
P
P
Y
A
A
P
E
-
L
--
F
------
Q
-
G
K
--
K
----
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
40.97
31%
-56
- C2 -
-
4WNP
1
ULK1_HUMAN
D:
[14-240]
----------
T
V
G
K
F
E
F
S
R
K
D
-----
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
--
V
A
V
K
C
I
-
N
K
K
N
L
A
-
K
S
--
Q
T
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
A
------
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
--------
H
A
M
R
T
L
--
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
N
-
P
A
---------
G
RRANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
-------
Q
S
N
M
-
M
A
A
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
-----
S
P
Q
-
D
L
R
L
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
40.89
36%
14
- C2 -
-
6HXF
4
STK10_HUMAN
D:
[16-290]
--------------
D
P
N
E
V
W
E
-----
I
V
G
E
L
G
D
G
A
F
-
G
K
V
Y
K
A
K
N
K
E
-
T
GA
L
A
A
A
K
V
-
I
E
T
K
S
E
-
E
E
--
L
E
D
----
Y
I
V
E
I
E
I
-
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
--
I
-
H
R
D
L
K
A
G
N
V
L
---
M
---
T
L
-
E
G
---------
D
---------
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
L
Q
K
---
R
D
-
F
I
G
T
P
Y
W
M
A
P
E
V
V
--
M
----
C
-
E
-
M
K
---P---
Y
D
Y
-
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-----
N
P
M
-
R
V
L
L
K
I
----
A
K
S
D
--
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
-
I
T
S
N
K
A
L
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
40.56
32%
-64
- C2 -
-
6QAU
5
ULK2_HUMAN
A:
[12-233]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
K
N
L
S
-
K
S
--
Q
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
N
RRKSSVSGI
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
H
S
------
N
M
M
-
A
A
D
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
40.44
31%
-50
- C2 -
-
5CI7
4
ULK1_HUMAN
A:
[14-240]
----------
T
V
G
K
F
E
F
S
R
K
D
-----
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
--
V
A
V
K
C
I
-
N
K
K
N
L
A
-
K
S
--
Q
T
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
A
------
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
--------
H
A
M
R
T
L
--
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
N
-
P
A
---------
G
RRANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
-------
Q
S
N
M
-
M
A
A
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
-----
S
P
Q
-
D
L
R
L
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
40.43
31%
-52
- C2 -
-
4WNP
3
ULK1_HUMAN
A:
[14-240]
----------
T
V
G
K
F
E
F
S
R
K
D
-----
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
--
V
A
V
K
C
I
-
N
K
K
N
L
A
-
K
S
--
Q
T
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
A
------
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
--------
H
A
M
R
T
L
--
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
N
-
P
A
---------
G
RRANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
-------
Q
S
N
M
-
M
A
A
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
-----
S
P
Q
-
D
L
R
L
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
40.42
31%
-52
- C2 -
-
4WNP
1
ULK1_HUMAN
C:
[14-240]
----------
T
V
G
K
F
E
F
S
R
K
D
-----
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
--
V
A
V
K
C
I
-
N
K
K
N
L
A
-
K
S
--
Q
T
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
A
------
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
--------
H
A
M
R
T
L
--
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
N
-
P
A
---------
G
RRANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
-------
Q
S
N
M
-
M
A
A
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
-----
S
P
Q
-
D
L
R
L
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
40.29
32%
-70
- C2 -
-
6QAT
2
ULK2_HUMAN
C:
[12-233]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
K
N
L
S
-
K
S
--
Q
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
-SGI------
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
H
------------------
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
39.93
32%
-49
- C2 -
-
6QAV
5
ULK2_HUMAN
D:
[12-273]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
K
N
L
S
-
K
S
--
Q
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
N
RRKSSVSGI
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
H
S
------
N
M
M
-
A
A
D
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
39.48
32%
-52
- C2 -
-
6QAV
5
ULK2_HUMAN
A:
[12-233]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
K
N
L
S
-
K
S
--
Q
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
N
RRKSSVSGI
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
H
S
------
N
M
M
-
A
A
D
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
39.23
32%
-49
- C2 -
-
6QAV
5
ULK2_HUMAN
C:
[12-233]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
K
N
L
S
-
K
S
--
Q
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
N
RRKSSVSGI
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
H
S
------
N
M
M
-
A
A
D
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
37.63
32%
-34
- C2 -
-
5F9E
1
B:
[16-253]
-----------
L
K
I
E
D
F
E
L
H
K
-----
M
L
G
K
G
S
F
G
K
V
-
F
L
A
E
F
K
K
T
N
Q
-
F
--
F
A
I
K
A
---
L
K
K
D
V
-
V
L
--
M
D
D
DVEC
T
M
V
E
K
R
V
-
L
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
------
E
N
L
F
F
V
M
E
Y
L
N
G
G
---
D
L
M
Y
H
I
--
Q
S
C
H
K
---
F
--
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
--
V
-
Y
R
D
L
K
L
D
N
I
L
---
L
---
D
K
-
D
G
---------
H
---------
I
K
I
A
D
F
G
M
C
K
-
E
N
M
L
G
D
A
K
T
N
E
------
F
C
G
T
P
D
Y
I
A
P
E
-
I
--
L
----
L
-
G
-
Q
K
-------
Y
N
H
-
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
37.39
32%
-38
- C2 -
-
6QAV
7
ULK2_HUMAN
B:
[12-233]
---------------
E
Y
S
K
R
D
-----
L
V
G
H
G
A
F
A
V
V
-
F
R
G
R
H
R
Q
K
T
D
W
E
--
V
A
I
K
S
I
-
N
K
K
N
L
S
-
K
S
--
Q
I
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
Q
H
E
N
I
V
A
L
Y
D
V
Q
E
L
P
------
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
Q
--------
A
K
G
T
L
--
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
Y
-
A
-SVSGI----
R
---------
I
K
I
A
D
F
G
F
A
R
Y
L
H
S
------
N
M
M
-
A
A
D
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
-----
S
P
Q
-
D
L
R
M
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
35.58
33%
-32
- C2 -
-
4RA5
3
KPCT_HUMAN
A:
[5-207]
--------------
E
D
F
E
L
H
K
-----
M
L
G
K
G
S
F
G
K
V
-
F
L
A
E
F
K
K
T
N
Q
-
F
--
F
A
I
K
A
---
L
K
K
D
V
-
V
L
--
M
D
D
DVEC
T
M
V
E
K
R
V
-
L
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
------
E
N
L
F
F
V
M
E
Y
L
N
G
G
---
D
L
M
Y
H
I
--
Q
S
C
H
K
---
F
--
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
--
V
-
Y
R
D
L
K
L
D
N
I
L
---
L
---
D
K
-
D
G
---------
H
---------
I
K
I
A
D
F
G
M
C
K
-
E
N
M
L
G
D
A
K
T
N
E
------
F
C
G
T
P
D
Y
I
A
P
E
-
I
--
L
----
L
-
G
-
Q
K
-------
Y
N
H
-
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
32.92
32%
-47
- C2 -
-
6MNH
2
ULK1_HUMAN
A:
[7-233]
----------
T
V
G
K
F
E
F
S
R
K
D
-----
L
I
G
H
G
A
F
A
V
V
-
F
K
G
R
H
R
E
K
H
D
L
E
--
V
A
V
K
C
I
-
N
K
K
N
L
A
-
K
S
--
Q
T
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
K
H
E
N
I
V
A
L
Y
-
D
F
Q
E
M
------
A
N
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
--------
H
A
M
R
T
L
--
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
N
-------------SIR------
V
K
I
A
D
F
G
F
A
R
Y
L
Q
-------------
T
--
L
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
A
Q
--
H
----
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
A
-----
S
P
Q
-
D
L
R
L
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
31.96
31%
-17
- C2 -
-
6QAS
7
ULK1_HUMAN
B:
[14-240]
----------
T
V
G
K
F
E
F
S
R
K
D
-----
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
--
V
A
V
K
C
I
-
N
K
K
N
L
A
-
K
S
--
Q
T
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
K
H
E
N
I
V
A
L
Y
-
D
F
Q
E
M
------
A
N
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
--------
H
A
M
R
T
L
--
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
N
-
P
A
---------
G
RRANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
-------
Q
S
N
M
-
M
A
A
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
-----
S
P
Q
-
D
L
R
L
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
31.26
31%
-11
- C2 -
-
6QAS
14
ULK1_HUMAN
A:
[14-240]
----------
T
V
G
K
F
E
F
S
R
K
D
-----
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
--
V
A
V
K
C
I
-
N
K
K
N
L
A
-
K
S
--
Q
T
L
----
L
G
K
E
I
K
I
-
L
K
E
-
L
-
K
H
E
N
I
V
A
L
Y
-
D
F
Q
E
M
------
A
N
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
--------
H
A
M
R
T
L
--
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
--
I
-
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
N
-
P
A
---------
G
RRANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
-------
Q
S
N
M
-
M
A
A
-
L
C
G
S
P
M
Y
M
A
P
E
-
V
--
I
------
M
-
S
Q
--
H
----
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
-----
S
P
Q
-
D
L
R
L
F
Y
----
E
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------