@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PASK_HUMAN: (2021-11-23 )
MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQSRTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSSPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVEALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVSTWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSVGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGINHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGERTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSCLSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS
Atome Classification :
(247 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950....---...960.......970--------...--....980.......990...--....1000......1010......1020......1030....-.----.1040....----..1050--........1060-.--........1070......1080......1090.----...-..1100......1110......1120......1130...---.---.----.1140---........1150-......1160-.......1170.--.-----..-----..1180......1190.-----...------..1200-----.--.------...--.1210---..-.----.--.--..---------1220-------......--------...1230-----........--.1240--.........1250......1260......1270......1280.....--.1290......-1300..------....1310......1320
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEDGGLT
A
F
E
E
D
Q
R
C
L
S
QSLPLPVSAEGPAAQTTAEPSR
S
F
S
S
A
H
R
H
L
S
R
R
N
G
L
S
R
L
C
Q
S
R
TALS
E
D
R
W
S
S
Y
C
L
S
S
L
A
A
Q
N
I
C
TSKLHCPAAPEHTDPSEPRG
S
V
S
C
C
S
L
L
R
G
L
S
SGWSSPLLPAPVCNPN
K
A
I
F
T
VDA
K
T
T
E
I
L
V
ANDKACGLLGYS
S
Q
D
L
I
G
Q
K
L
T
Q
F
F
LRS
D
S
D
V
V
E
A
L
S
E
E
H
MEADG
H
A
A
V
V
F
G
T
V
V
D
I
I
SRSGEKI
P
V
S
V
W
M
K
R
M
R
Q
ERR
L
C
C
V
V
V
L
E
P
V
E
R
V
S
T
W
V
A
FQSDGTVT
S
C
D
S
L
F
A
H
L
H
G
YVSGEDV
A
G
Q
H
I
T
D
LIPSVQLPPSGQHIPKN
L
K
I
Q
R
SVGRARDG
T
T
F
P
L
S
L
K
LKSQPSSEEATTGEAAPVSG
Y
R
A
S
V
W
V
F
C
TI
S
G
L
I
T
LLPDGTIHGIN
H
S
F
A
L
T
L
F
GY
G
K
T
E
LLGKN
I
T
F
L
I
P
G
F
Y
S
Y
M
D
L
AYNSSLQL
P
D
L
A
S
C
L
DVGNESGCGERTLDPWQGQDPAEGGQD
P
R
I
N
V
V
L
AGGHVV
P
R
D
E
I
R
K
L
M
E
SQDIFTGTQ
T
E
L
IAGGQ
L
L
S
CLSPQPAPGVDNVPEGSLPVHGEQALPKDQ
Q
I
T
ALGREE
P
V
AIESP
G
Q
D
L
LGESRSEPVDVKPFASCEDSEAPVPAEDGGSDA
G
M
C
G
L
C
Q
K
A
Q
L
E
R
MGVSGPSGSDLWAGAAVAKPQAKGQLAGG
S
L
L
M
HCPCYGSEWG
L
W
W
RSQDLAPSPSGMAGLSFGTPTLDEPWLGVEN
D
R
E
E
L
Q
T
C
L
I
K
E
Q
L
S
Q
LSLAGALDVPHAELVPTEC
Q
A
VTAP
V
S
SCDLGGRDLCGGCTGSSS
A
C
Y
A
L
ATDLPGGLEA
V
E
A
QEVDVNSFS
W
N
L
K
E
L
FFSDQTDQTSSNCSC
A
T
S
E
L
RETPSSLAVGSDPDVG
S
L
Q
EQG
S
C
V
LDDR
E
L
L
L
L
T
GTCVDLGQG
R
R
F
R
E
S
CVGHDPTE
P
L
E
V
C
L
VSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEE
P
R
L
N
V
Q
V
TST
P
V
I
V
M
RGAA
G
L
Q
R
E
I
Q
EGAYSG
S
C
Y
H
RD
G
L
R
L
S
I
Q
F
E
V
R
R
V
E
LQGP
T
P
L
F
C
C
W
L
V
K
D
L
L
H
SQRDS
A
A
R
T
R
L
F
L
ASLPGSTHS---
T
A
A
ELT
G
P
S
L
V
E
V
L
R
A--------RPW--FEEPPK
A
V
E
LE
G
L
AACEG
E
Y
--SQKYSTMSPLGSGA
F
G
F
V
W
T
AVDKEK
N
K
E
V
V
V
K
F
I
K
K
E
K
V
L
E
-
D
----CWIEDPKL
G
----
K
V
T
--
L
--
E
I
A
I
L
S
RVE----H--A
N
I
I
K
V
L
D
I
FENQ
G
F
F
Q
L
V
M
E
KHGSGL
D
L
F
A
F
I
----DRH-PRLD
E
P
L
A
S
Y
I
F
R
Q
L
V
S
A
V
G
Y
L
R
L
K
D
I
I
H
RDIKDE
N
I
V
I
---A---E----D
F
-
T
----
I
K
L
I
DFG
S
A
A
Y
L
-ERG
K
L
F
Y
T
-
F
-CG
T
I
E
YCA
P
E
VL--M-----GN-----PYRGPE
L
E
M
W
S
L
G
V
T
L
Y
-----
T
L
V
------FEENPF-----C--
E
------
L
E
E
--
T
V
-
E
A
---AI-H----P--
P
--
Y
L
---------
V
----------
S
K
E
L
M
S
--------
L
V
S
G
--------
L
LQPVP
E
R
--
R
T
-----
T
L
E
K
LVTDPWVTQPVN
L
A
D
Y
T
W
E
E
V
F
RVNKPESGV
L
S
A
A
S
LEMGN
R
S
L
--
S
D
V
A
Q
A
Q
E
LCG-GPVPGE------APNGQGCLHPGDPRLLTS
1
PsiBlast_PDB
94.09
99%
-129
- C3 -
-
3DLS
1
PASK_HUMAN
A:
[9-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
E
L
E
G
L
A
A
C
E
G
E
Y
--
S
Q
K
Y
S
T
M
S
P
L
G
S
G
A
F
G
F
V
W
T
A
V
D
K
E
K
N
K
E
V
V
V
K
F
I
K
K
E
K
V
L
E
-
D
----
C
W
I
E
D
P
K
L
G
----
K
V
T
--
L
--
E
I
A
I
L
S
R
V
E
----
H
--
A
N
I
I
K
V
L
D
I
F
E
N
Q
G
F
F
Q
L
V
M
E
K
H
G
S
G
L
D
L
F
A
F
I
----
D
R
H
-
P
R
L
D
E
P
L
A
S
Y
I
F
R
Q
L
V
S
A
V
G
Y
L
R
L
K
D
I
I
H
R
D
I
K
D
E
N
I
V
I
---
A
---
E
----
D
F
-
T
----
I
K
L
I
D
F
G
S
A
A
Y
L
-
E
R
G
K
L
F
Y
T
-
F
-
C
G
T
I
E
Y
C
A
P
E
V
L
--
M
-----
G
N
-----
P
Y
R
G
P
E
L
E
M
W
S
L
G
V
T
L
Y
-----
T
L
V
------
F
E
E
N
P
F
-----
C
--
E
------
L
E
E
--
T
V
-
E
A
---
A
I
-
H
----
P
--
P
--
Y
L
---------
V
----------
S
K
E
L
M
S
--------
L
V
S
G
--------
L
L
Q
P
V
P
E
R
--
R
T
-----
T
L
E
K
L
V
T
D
P
W
V
T
Q
P
V
N
L
A
D
Y
T
W
E
E
V
F
------------------------------------------------------------------
515
HHSearch
93.82
99%
-132
- C3 -
-
3DLS
1
PASK_HUMAN
A:
[14-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
A
A
C
E
G
E
Y
--
S
Q
K
Y
S
T
M
S
P
L
G
S
G
A
F
G
F
V
W
T
A
V
D
K
E
K
N
K
E
V
V
V
K
F
I
K
K
E
K
V
L
E
-
D
----
C
W
I
E
D
P
K
L
G
----
K
V
T
--
L
--
E
I
A
I
L
S
R
V
E
----
H
--
A
N
I
I
K
V
L
D
I
F
E
N
Q
G
F
F
Q
L
V
M
E
K
H
G
S
G
L
D
L
F
A
F
I
----
D
R
H
-
P
R
L
D
E
P
L
A
S
Y
I
F
R
Q
L
V
S
A
V
G
Y
L
R
L
K
D
I
I
H
R
D
I
K
D
E
N
I
V
I
---
A
---
E
----
D
F
-
T
----
I
K
L
I
D
F
G
S
A
A
Y
L
-
E
R
G
K
L
F
Y
T
-
F
-
C
G
T
I
E
Y
C
A
P
E
V
L
--
M
-----
G
N
-----
P
Y
R
G
P
E
L
E
M
W
S
L
G
V
T
L
Y
-----
T
L
V
------
F
E
E
N
P
F
-----
C
--
E
------
L
E
E
--
T
V
-
E
A
---
A
I
-
H
----
P
--
P
--
Y
L
---------
V
----------
S
K
E
L
M
S
--------
L
V
S
G
--------
L
L
Q
P
V
P
E
R
--
R
T
-----
T
L
E
K
L
V
T
D
P
W
V
T
Q
P
V
N
L
A
D
Y
T
W
E
E
V
F
------------------------------------------------------------------
21
Blastp_CBE
92.82
99%
-128
- C3 -
-
3DLS
5
F:
[9-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
E
L
E
G
L
A
A
C
E
G
E
Y
--
S
Q
K
Y
S
T
M
S
P
L
G
S
G
A
F
G
F
V
W
T
A
V
D
K
E
K
N
K
E
V
V
V
K
F
I
K
K
E
K
V
---------
W
I
E
D
P
K
L
G
----
K
V
T
--
L
--
E
I
A
I
L
S
R
V
E
----
H
--
A
N
I
I
K
V
L
D
I
F
E
N
Q
G
F
F
Q
L
V
M
E
K
H
G
S
G
L
D
L
F
A
F
I
----
D
R
H
-
P
R
L
D
E
P
L
A
S
Y
I
F
R
Q
L
V
S
A
V
G
Y
L
R
L
K
D
I
I
H
R
D
I
K
D
E
N
I
V
I
---
A
---
E
----
D
F
-
T
----
I
K
L
I
D
F
G
S
A
A
Y
L
-
E
R
G
K
L
F
Y
T
-
F
-
C
G
T
I
E
Y
C
A
P
E
V
L
--
M
-----
G
N
-----
P
Y
R
G
P
E
L
E
M
W
S
L
G
V
T
L
Y
-----
T
L
V
------
F
E
E
N
P
F
-----
C
--
E
------
L
E
E
--
T
V
-
E
A
---
A
I
-
H
----
P
--
P
--
Y
L
---------
V
----------
S
K
E
L
M
S
--------
L
V
S
G
--------
L
L
Q
P
V
P
E
R
--
R
T
-----
T
L
E
K
L
V
T
D
P
W
V
T
Q
P
V
N
L
A
D
Y
T
W
E
E
V
F
------------------------------------------------------------------
540
Fugue
65.19
21%
-7
- C3 -
-
3C4Z
1
GRK1_BOVIN
A:
[31-533]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
-
S
F
L
D
A
E
T
V
A
R
A
R
A
G
---
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
--------
A
P
F
QE
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
MG
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
-
R
---------
K
G
Y
Q
----
G
A
M
--
V
--
E
K
K
I
L
A
K
V
H
----
S
--
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
-
D
I
R
Y
H
I
YNVD
E
D
N
-
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
---
D
---
D
----
D
G
-
N
----
V
R
I
S
D
L
G
L
A
V
E
L
-
K
A
G
Q
T
K
T
K
G
Y
-
A
G
T
P
G
F
M
A
P
E
L
L
--
L
-----
G
E
-----
E
Y
-
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
-----
E
M
I
------
A
A
R
G
P
F
-----
R
--
A
------
R
G
E
--
K
V
-
E
N
---
K
E
-
L
----
K
--
Q
--
R
V
---------
L
EQAVTYPDKF
S
P
A
S
K
D
--------
F
C
E
A
--------
L
L
Q
K
D
P
E
K
--
R
L
GFRDG
S
C
D
G
L
R
T
H
P
L
F
-
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
EK
A
D
T
E
F
F
Q
E
F
A
S
-
G
T
C
P
I
P
WQEEMI
E
T
G
V
F
G
D
L
N
V
W
R
P
-----
13
PsiBlast_PDB
63.75
36%
-108
- C3 -
-
3IEC
-
MARK2_HUMAN
A:
[9-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
-----------
L
N
S
S
S
L
Q
----
K
L
F
--
R
--
E
V
R
I
M
K
V
L
N
----
H
--
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
-
Y
A
S
G
G
E
V
F
D
Y
L
----
V
A
H
-
G
W
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
---
A
----
D
M
-
N
----
I
K
I
A
D
F
G
F
S
N
E
F
-
T
F
G
N
K
L
D
T
-
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
-----
G
K
-----
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
-----
T
L
V
------
S
G
S
L
P
F
DGQNL
K
--
E
------
L
R
E
--
R
V
L
R
G
---
K
Y
-
R
----
I
--
P
--
F
Y
---------
M
----------
S
T
D
C
E
N
--------
L
L
K
K
--------
F
L
I
L
N
P
S
K
--
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
---------------------------------------------------------------------------------
196
Blastp_CBE
63.30
32%
-104
- C3 -
-
5ISO
2
?
A:
[22-369]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
-
L
----
D
V
V
-----
G
----
K
I
K
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
F
L
R
T
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
ALLCG
T
L
P
------
F
D
D
E
H
V
-----
P
--
T
------
L
F
K
--
K
I
-
R
G
---
G
V
F
Y
----
I
--
P
--
E
Y
---------
L
----------
N
R
S
V
A
T
--------
L
L
M
H
--------
M
L
Q
V
D
P
L
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
S
Y
L
F
P
E
--------------------------------------------------------------------
18
PsiBlast_PDB
62.79
35%
-102
- C3 -
-
6C9D
-
MARK1_HUMAN
A:
[23-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
Q
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
V
L
T
G
R
E
V
A
V
K
I
I
D
K
T
Q
-----------
L
N
P
T
S
L
Q
----
K
L
F
--
R
--
E
V
R
I
M
K
I
L
N
----
H
--
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
-
Y
A
S
G
G
E
V
F
D
Y
L
----
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
Y
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
---
G
----
D
M
-
N
----
I
K
I
A
D
F
G
F
S
N
E
F
-
T
V
G
N
K
L
D
E
-
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
-----
G
K
-----
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
-----
T
L
V
SGSLP-
F
D
G
Q
N
L
-----
K
--
E
------
L
R
E
--
R
V
L
R
G
---
K
Y
-
R
----
I
--
P
--
F
Y
---------
M
----------
S
T
D
C
E
N
--------
L
L
K
K
--------
L
L
V
L
N
P
I
K
--
R
G
-----
S
L
E
Q
I
M
K
D
R
W
M
N
--------------------------------------------------------------------------------
255
Blastp_CBE
62.56
33%
-65
- C3 -
-
2CKE
1
DAPK2_HUMAN
B:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
------
R
R
G
V
S
R
E
----
E
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
S
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
HTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
259
Blastp_CBE
62.52
33%
-62
- C3 -
-
2A2A
2
DAPK2_HUMAN
B:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
------
R
R
G
V
S
R
E
----
E
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
S
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
HTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
542
Fugue
62.46
23%
14
- C3 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
QCF
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
NNSPLRRE
K
N
I
--
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
--
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
-
R
---------
A
E
T
A
----
C
F
R
--
E
--
E
R
D
V
L
V
N
G
D
----
S
--
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
-
D
L
L
T
L
L
----
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
---
D
---
M
----
N
G
-
H
----
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
-
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
--
Q
-----
A
M
EGGKG
R
Y
-
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
-----
E
M
L
------
Y
G
E
T
P
F
-----
Y
--
A
ES----
L
V
E
--
T
Y
-
G
K
---
I
M
-
N
----
H
--
K
--
E
R
FQFPTQVTD
V
----------
S
E
N
A
K
D
--------
L
I
R
R
--------
L
I
C
S
R
E
H
R
LG
Q
N
-----
G
I
E
D
F
K
K
H
P
F
F
S
------
G
I
D
W
D
N
I
R
N
C
E
A
P
Y
--
I
P
E
V
S
S
P
T
D
T
S
N
F
D
--
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
------
V
L
S
D
R
S
C
L
R
---------
258
Blastp_CBE
62.28
33%
-61
- C3 -
-
2A2A
3
DAPK2_HUMAN
C:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
------
R
R
G
V
S
R
E
----
E
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
S
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
HTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
256
Blastp_CBE
62.20
33%
-61
- C3 -
-
2CKE
1
DAPK2_HUMAN
A:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
------
R
R
G
V
S
R
E
----
E
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
S
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
HTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
252
Blastp_CBE
62.15
31%
-60
- C3 -
-
3LIJ
1
?
A:
[15-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
F
Q
G
D
L
Q
A
T
P
G
M
F
I
T
S
K
K
G
H
L
--
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
----------------
S
S
N
S
----
K
L
L
--
E
--
E
V
A
V
L
K
L
L
D
----
H
--
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
-
E
L
F
D
E
I
----
I
H
R
-
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
E
---
K
----
D
A
-
L
----
I
K
I
V
D
F
G
L
S
A
V
F
-
E
N
Q
K
K
M
K
E
-
R
-
L
G
T
A
Y
Y
I
A
P
E
V
L
---------
R
-----
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
-----
I
L
L
------
A
G
Y
P
P
F
GGQTD
Q
--
E
------
I
L
R
--
K
V
-
E
K
---
G
K
-
Y
TFDS
P
--
E
--
W
K
N--------
V
----------
S
E
G
A
K
D
--------
L
I
K
Q
--------
M
L
Q
F
D
S
Q
R
--
R
I
-----
S
A
Q
Q
A
L
E
H
P
W
I
K
E
-------------------------------------------------------------------------------
272
Blastp_CBE
62.01
33%
-64
- C3 -
-
2A27
2
DAPK2_HUMAN
C:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
------
R
R
G
V
S
R
E
----
E
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
A
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
QTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
260
Blastp_CBE
61.80
33%
-56
- C3 -
-
2A2A
3
DAPK2_HUMAN
A:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
------
R
R
G
V
S
R
E
----
E
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
S
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
HTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
270
Blastp_CBE
61.79
33%
-60
- C3 -
-
2A27
1
DAPK2_HUMAN
E:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
------
R
R
G
V
S
R
E
----
E
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
A
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
QTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
26
Blastp_CBE
61.80
36%
-97
- C3 -
-
5EAK
1
MARK2_HUMAN
B:
[15-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
-----------
L
N
S
S
S
L
Q
----
K
L
F
--
R
--
E
V
R
I
M
K
V
L
N
----
H
--
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
-
Y
A
S
G
G
E
V
F
D
Y
L
----
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
---
A
----
D
M
-
N
----
I
K
I
A
D
F
G
---------------
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
-----
G
K
-----
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
-----
T
L
V
------
S
G
S
L
P
F
DGQNL
K
--
E
------
L
R
E
--
R
V
L
R
G
---
K
Y
-
R
----
I
--
P
--
F
Y
---------
M
----------
S
T
D
C
E
N
--------
L
L
K
K
--------
F
L
I
L
N
P
S
K
--
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
---------------------------------------------------------------------------------
7
PsiBlast_PDB
61.80
36%
-95
- C3 -
-
5KZ8
1
MARK2_HUMAN
A:
[30-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
--
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
-----------
L
N
S
S
S
L
Q
----
K
L
F
--
R
--
E
V
R
I
M
K
V
L
N
----
H
--
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
-
Y
A
S
G
G
E
V
F
D
Y
L
----
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
---
A
----
D
M
-
N
----
I
K
I
A
D
F
G
-----------------
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
-----
G
K
-----
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
-----
T
L
V
------
S
G
S
L
P
F
DGQNL
K
--
E
------
L
R
E
--
R
V
L
R
G
---
K
Y
-
R
----
I
--
P
--
F
Y
---------
M
----------
S
T
D
C
E
N
--------
L
L
K
K
--------
F
L
I
L
N
P
S
K
--
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
---------------------------------------------------------------------------------
28
Blastp_CBE
61.79
36%
-113
- C3 -
-
5KZ7
1
MARK2_HUMAN
B:
[30-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
--
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
-----------
L
N
S
S
S
L
Q
----
K
L
F
--
R
--
E
V
R
I
M
K
V
L
N
----
H
--
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
-
Y
A
S
G
G
E
V
F
D
Y
L
----
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
---
A
----
D
M
-
N
----
I
K
I
A
D
F
-------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
-----
G
K
-------
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
-----
T
L
V
------
S
G
S
L
P
F
DNL--
K
--
E
------
L
R
E
--
R
V
L
R
G
---
K
Y
-
R
----
I
--
P
--
F
Y
---------
M
----------
S
T
D
C
E
N
--------
L
L
K
K
--------
F
L
I
L
N
P
S
K
--
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
---------------------------------------------------------------------------------
268
Blastp_CBE
61.66
33%
-61
- C3 -
-
2A27
2
DAPK2_HUMAN
G:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
------
R
R
G
V
S
R
E
----
E
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
A
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
QTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
254
Blastp_CBE
61.31
33%
-64
- C3 -
-
2CKE
1
DAPK2_HUMAN
C:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
------
R
R
G
V
S
R
E
----
E
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
S
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
HTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
253
Blastp_CBE
61.08
33%
-60
- C3 -
-
2CKE
1
DAPK2_HUMAN
D:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
------
R
R
G
V
S
R
E
----
E
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
S
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
HTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
47
Blastp_CBE
60.35
35%
-87
- C3 -
-
5TUR
1
PIM1_HUMAN
A:
[128-381]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
-
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
----
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
251
Blastp_CBE
60.14
34%
-62
- C3 -
-
3HZT
9
?
A:
[3-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
----------
T
T
T
S
N
S
G
----
A
L
L
--
D
--
E
V
A
V
L
K
Q
L
D
----
H
--
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
-
E
L
F
D
E
I
----
I
L
R
-
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
---
R
----
D
A
-
L
----
I
K
I
V
D
F
G
L
S
A
H
F
-
E
V
----------
G
T
A
Y
Y
I
A
P
E
V
L
---------
R
-----
K
K
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
-----
I
L
L
------
C
G
Y
P
P
F
GGQTD
Q
--
E
------
I
L
K
--
R
V
-
E
K
GKF
S
F
-
D
----
P
--
P
DW
T
Q
---------
V
----------
S
D
E
A
K
Q
--------
L
V
K
L
--------
M
L
T
Y
E
P
S
K
--
R
I
-----
S
A
E
E
A
L
N
H
P
W
I
V
K
-------------------------------------------------------------------------------
352
Blastp_CBE
58.56
35%
-90
- C3 -
-
2YCS
1
CHK2_HUMAN
A:
[11-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
317
Blastp_CBE
58.14
35%
-83
- C3 -
-
2CN5
1
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
------------------
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
201
Blastp_CBE
58.13
31%
-43
- C3 -
-
6C9H
2
AAPK1_HUMAN
A:
[22-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
F
L
R
T
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
95
Blastp_CBE
57.40
34%
-14
- C3 -
-
5V80
1
PIM1_HUMAN
A:
[10-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
-
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------------------------------------------------------
83
Blastp_CBE
57.40
35%
-20
- C3 -
-
3R02
4
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
69
Blastp_CBE
57.06
35%
-46
- C3 -
-
4ENY
3
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
-
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
----------
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
S---
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
200
Blastp_CBE
57.03
31%
-43
- C3 -
-
4REW
1
AAPK1_HUMAN
A:
[14-400]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
F
L
R
T
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
51
Blastp_CBE
56.95
35%
-22
- C3 -
-
4MTA
2
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
121
Blastp_CBE
56.89
35%
-17
- C3 -
-
6BSK
5
PIM1_HUMAN
A:
[8-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
39
Blastp_CBE
56.63
34%
-19
- C3 -
-
5KZI
1
PIM1_HUMAN
A:
[14-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
--
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
344
Blastp_CBE
56.58
32%
1
- C3 -
-
3I7B
4
?
A:
[24-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
------------
K
T
D
----
K
E
S
--
L
LR
E
V
Q
L
L
K
Q
L
D
----
H
--
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
-
E
L
F
D
E
I
----
I
S
R
-
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
---
K
----
D
A
-
N
----
I
R
I
I
D
F
G
L
S
T
H
F
-
E
A
S
K
K
M
K
D
-
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
-----
G
T
-----
Y
--
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
-----
I
L
L
------
S
G
C
P
P
F
NGANE
Y
--
D
------
I
L
K
--
K
V
-
E
K
---
G
K
-
Y
----
T
--
F
--
E
L
PQWKK----
V
----------
S
E
S
A
K
D
--------
L
I
R
K
--------
M
L
T
Y
V
P
S
M
--
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
T
------
Y
T
K
E
Q
I
-------------------------------------------------------------------
67
Blastp_CBE
56.50
35%
-21
- C3 -
-
4LMU
2
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
----
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
97
Blastp_CBE
56.47
34%
-12
- C3 -
-
5DHJ
1
PIM1_HUMAN
A:
[10-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
-
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------------------------------------------------------
529
HHSearch
56.44
34%
-13
- C3 -
-
5KGG
22
PIM1_HUMAN
A:
[5-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-
W
----
G
--
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
----
S
GF
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L--
N
----
R
G
-
E
----
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
-
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
-----------------------------------------------------------------------------
238
Blastp_CBE
56.42
32%
-5
- C3 -
-
4IEB
1
?
A:
[47-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
---------------
T
D
----
K
E
S
--
L
LR
E
V
Q
L
L
K
Q
L
D
----
H
--
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
-
E
L
F
D
E
I
----
I
S
R
-
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
---
K
----
D
A
-
N
----
I
R
I
I
D
F
G
L
S
T
H
F
-
E
A
S
K
K
M
K
D
-
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
-----
G
T
-----
Y
--
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
-----
I
L
L
------
S
G
C
P
P
F
NGANE
Y
--
D
------
I
L
K
--
K
V
-
E
K
---
G
K
-
Y
----
T
--
F
--
E
-PQWKK----
V
----------
S
E
S
A
K
D
--------
L
I
R
K
--------
M
L
T
Y
V
P
S
M
--
R
I
-----
S
A
R
D
A
L
D
H
E
W
I
Q
T
------
Y
T
K
E
Q
I
-------------------------------------------------------------------
96
Blastp_CBE
56.31
34%
-13
- C3 -
-
5DIA
1
PIM1_HUMAN
A:
[10-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
-
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
-----------------------------------------------------------------
133
Blastp_CBE
56.18
35%
-19
- C3 -
-
5N4Y
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
94
Blastp_CBE
56.18
34%
-13
- C3 -
-
5V82
1
PIM1_HUMAN
A:
[10-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
-
Q
D
V
L
L
P
Q
E
T
A
E
I
H
L
H
S
----------------------------------------------------------------
128
Blastp_CBE
56.12
35%
-17
- C3 -
-
2J2I
1
PIM1_HUMAN
B:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
210
Blastp_CBE
56.09
32%
-112
- C3 -
-
6B2E
2
AAPK2_HUMAN
A:
[35-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
-
L
----
D
V
V
-----
G
----
K
I
K
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
ALLCG
T
L
P
------
F
D
D
E
H
V
-----
P
--
T
------
L
F
K
--
K
I
-
R
G
---
G
V
F
Y
----
I
--
P
--
E
Y
---------
L
----------
N
R
S
V
A
T
--------
L
L
M
H
--------
M
L
Q
V
D
P
L
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
-------------------------------------------------------------------------------
137
Blastp_CBE
56.09
35%
-20
- C3 -
-
5N4R
2
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
309
Blastp_CBE
56.05
35%
-81
- C3 -
-
2XM9
1
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------
P
A
L
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
124
Blastp_CBE
56.00
35%
-19
- C3 -
-
5KGG
22
PIM1_HUMAN
A:
[8-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
92
Blastp_CBE
55.95
35%
-18
- C3 -
-
4ALW
3
PIM1_HUMAN
A:
[52-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
79
Blastp_CBE
55.93
35%
-23
- C3 -
-
3VBV
1
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
---
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
516
HHSearch
55.88
34%
-32
- C3 -
-
5TUR
1
PIM1_HUMAN
A:
[125-386]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-
W
------
G
E
L
P
N
-
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
-----F-
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L--
N
----
R
G
-
E
----
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
-
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
L
----------------------------------------------------------------------------
42
Blastp_CBE
55.79
34%
-16
- C3 -
-
4WT6
2
PIM1_HUMAN
A:
[14-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
--
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
123
Blastp_CBE
55.77
35%
-13
- C3 -
-
5KGI
14
PIM1_HUMAN
A:
[8-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
301
Blastp_CBE
55.72
35%
-95
- C3 -
-
4BDD
3
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
43
Blastp_CBE
55.71
34%
-13
- C3 -
-
4WSY
2
PIM1_HUMAN
A:
[14-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
--
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
64
Blastp_CBE
55.64
35%
-16
- C3 -
-
1YXT
1
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
102
Blastp_CBE
55.63
35%
-18
- C3 -
-
3C4E
2
PIM1_HUMAN
D:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
297
Blastp_CBE
55.62
35%
-89
- C3 -
-
4BDH
4
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
263
Blastp_CBE
55.57
33%
-1
- C3 -
-
2YAA
1
DAPK2_MOUSE
B:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
RRGV
C
R
E
E
----------
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
A
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
QTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
45
Blastp_CBE
55.57
34%
-18
- C3 -
-
4TY1
2
PIM1_HUMAN
A:
[14-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
--
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
135
Blastp_CBE
55.54
35%
-15
- C3 -
-
5N4V
2
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
120
Blastp_CBE
55.53
35%
-17
- C3 -
-
3CXW
1
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
--
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
106
Blastp_CBE
55.51
35%
-22
- C3 -
-
4XH6
1
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
60
Blastp_CBE
55.50
35%
-17
- C3 -
-
1YXU
2
PIM1_HUMAN
D:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
350
Blastp_CBE
55.46
35%
-87
- C3 -
-
2YIR
1
CHK2_HUMAN
A:
[11-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------
L
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
264
Blastp_CBE
55.41
33%
1
- C3 -
-
2YAA
1
DAPK2_MOUSE
A:
[14-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
-
S
RRGV
C
R
E
E
----------
I
E
--
R
--
E
V
S
I
L
R
Q
V
L
----
H
--
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
K
N
-
I
PIPH
I
K
L
I
D
F
G
L
A
H
E
I
-
E
D
G
V
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
I
T
-
A
----
V
--
S
--
Y
D
---------
F
----------
D
E
E
F
F
S
QTSELAKD
F
I
R
K
--------
L
L
V
K
E
T
R
K
--
R
L
-----
T
I
Q
E
A
L
R
H
P
W
I
T
-
P
V
D
----------------------------------------------------------------------------
134
Blastp_CBE
55.41
35%
-19
- C3 -
-
5N4X
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
-
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
61
Blastp_CBE
55.41
35%
-20
- C3 -
-
1YXU
2
PIM1_HUMAN
C:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
82
Blastp_CBE
55.40
35%
-17
- C3 -
-
3R04
4
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
87
Blastp_CBE
55.38
35%
-21
- C3 -
-
4MBL
1
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
70
Blastp_CBE
55.37
35%
-21
- C3 -
-
4ENX
1
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
---
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
107
Blastp_CBE
55.36
35%
-16
- C3 -
-
3JYA
1
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
74
Blastp_CBE
55.35
35%
-23
- C3 -
-
5KCX
2
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
53
Blastp_CBE
55.32
35%
-17
- C3 -
-
4JX7
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
129
Blastp_CBE
55.27
35%
-15
- C3 -
-
5NDT
2
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
66
Blastp_CBE
55.26
35%
-19
- C3 -
-
5VUA
2
PIM1_HUMAN
B:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
125
Blastp_CBE
55.20
35%
-14
- C3 -
-
5KGE
16
PIM1_HUMAN
A:
[8-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
75
Blastp_CBE
55.19
35%
-16
- C3 -
-
3VC4
2
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
44
Blastp_CBE
55.19
34%
-13
- C3 -
-
4WRS
3
PIM1_HUMAN
A:
[14-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
--
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
63
Blastp_CBE
55.09
35%
-20
- C3 -
-
1YXU
2
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
38
Blastp_CBE
55.03
34%
-15
- C3 -
-
6MT0
3
PIM1_HUMAN
A:
[14-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
--
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
240
Blastp_CBE
55.02
34%
8
- C3 -
-
5VJA
3
DAPK3_HUMAN
D:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
R
-----------
L
S
-----VSRE
E
I
E
--
R
--
E
V
N
I
L
R
E
I
R
----
H
--
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
-------
E
K
-
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
VP--
N
P
-
R
----
I
K
L
I
D
F
G
I
A
H
K
I
-
E
A
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GE
T
------
K
Q
E
--
T
L
-
T
N
---
I
S
-
A
----
V
--
N
--
Y
D
---------
F
----------
D
E
E
Y
F
S
NTSELAKD
F
I
R
R
--------
L
L
V
K
D
P
K
R
--
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
---------------------------------------------------------------------------------
91
Blastp_CBE
55.00
35%
-12
- C3 -
-
4K0Y
1
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
293
Blastp_CBE
54.97
34%
-77
- C3 -
-
2JAM
3
KCC1G_HUMAN
A:
[14-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
-----------
S
S
L
E
N
----------------
E
I
A
V
L
K
K
I
K
----
H
--
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
-
V
S
G
G
E
L
F
D
R
I
----
L
E
R
-
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
LTP
E
---
E
----
N
S
-
K
----
I
M
I
T
D
F
G
L
S
K
-
M
-
E
Q
N
G
I
M
S
T
-
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
-----
Q
K
-----
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
-----
I
L
L
------
C
G
Y
P
P
F
-----
Y
--
E
ETESK-
L
F
E
--
K
I
-
K
E
---
G
Y
-
Y
EFE-
S
--
P
--
F
W
DD-------
I
----------
S
E
S
A
K
D
--------
F
I
C
H
--------
L
L
E
K
D
P
N
E
--
R
Y
-----
T
C
E
K
A
L
S
H
P
W
I
---------------------------------------------------------------------------------
380
Blastp_CBE
54.95
31%
1
- C3 -
-
5AV3
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
--
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
85
Blastp_CBE
54.92
35%
-16
- C3 -
-
3R00
2
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
381
Blastp_CBE
54.88
31%
5
- C3 -
-
5AV2
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
--
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
132
Blastp_CBE
54.82
35%
-16
- C3 -
-
5N4Z
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
58
Blastp_CBE
54.76
35%
-19
- C3 -
-
1YXX
2
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
122
Blastp_CBE
54.73
35%
-12
- C3 -
-
5KGK
7
PIM1_HUMAN
A:
[8-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
304
Blastp_CBE
54.72
35%
-87
- C3 -
-
4BDA
8
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
365
Blastp_CBE
54.67
31%
15
- C3 -
-
1WVY
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
294
Blastp_CBE
54.67
35%
-80
- C3 -
-
4BDK
4
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------
A
L
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
-
G
E
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
40
Blastp_CBE
54.68
34%
-11
- C3 -
-
5IPJ
4
PIM1_HUMAN
A:
[14-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
--
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
149
Blastp_CBE
54.67
35%
-15
- C3 -
-
4AS0
1
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
148
Blastp_CBE
54.64
35%
-12
- C3 -
-
6AYD
1
PIM1_HUMAN
A:
[59-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
37
Blastp_CBE
54.64
35%
-14
- C3 -
-
1XR1
1
PIM1_HUMAN
A:
[24-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
72
Blastp_CBE
54.63
35%
-18
- C3 -
-
3UMW
2
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
--------
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
311
Blastp_CBE
54.60
35%
-81
- C3 -
-
2XBJ
1
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------
A
L
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
126
Blastp_CBE
54.60
35%
-14
- C3 -
-
5KGD
20
PIM1_HUMAN
A:
[8-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
242
Blastp_CBE
54.59
34%
9
- C3 -
-
5VJA
2
DAPK3_HUMAN
B:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----------------
R
R
G
VSRE
E
I
E
--
R
--
E
V
N
I
L
R
E
I
R
----
H
--
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
KNVP
N
P
-
R
----
I
K
L
I
D
F
G
I
A
H
K
I
-
E
A
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GE
T
------
K
Q
E
--
T
L
-
T
N
---
I
S
-
A
----
V
--
N
--
Y
D
---------
F
----------
D
E
E
Y
F
S
NTSELAKD
F
I
R
R
--------
L
L
V
K
D
P
K
R
--
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
---------------------------------------------------------------------------------
146
Blastp_CBE
54.52
35%
-12
- C3 -
-
2BZH
2
PIM1_HUMAN
B:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
114
Blastp_CBE
54.53
35%
-16
- C3 -
-
6PDI
7
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
119
Blastp_CBE
54.52
35%
-16
- C3 -
-
3CY2
2
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
--
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
118
Blastp_CBE
54.46
35%
-17
- C3 -
-
3JPV
1
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
110
Blastp_CBE
54.45
35%
-20
- C3 -
-
5TOE
1
PIM1_HUMAN
A:
[4-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
-
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
84
Blastp_CBE
54.42
35%
-15
- C3 -
-
3R01
3
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
388
Blastp_CBE
54.39
31%
4
- C3 -
-
5AUV
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
--
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
243
Blastp_CBE
54.41
34%
13
- C3 -
-
5VJA
2
DAPK3_HUMAN
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
----------------
R
R
G
VSRE
E
I
E
--
R
--
E
V
N
I
L
R
E
I
R
----
H
--
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
KNVP
N
P
-
R
----
I
K
L
I
D
F
G
I
A
H
K
I
-
E
A
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GE
T
------
K
Q
E
--
T
L
-
T
N
---
I
S
-
A
----
V
--
N
--
Y
D
---------
F
----------
D
E
E
Y
F
S
NTSELAKD
F
I
R
R
--------
L
L
V
K
D
P
K
R
--
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
---------------------------------------------------------------------------------
314
Blastp_CBE
54.40
35%
-85
- C3 -
-
2WTD
4
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------
P
A
L
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
48
Blastp_CBE
54.39
35%
-15
- C3 -
-
4RPV
1
PIM1_HUMAN
A:
[134-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
136
Blastp_CBE
54.37
35%
-16
- C3 -
-
5N4U
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
150
Blastp_CBE
54.36
35%
-15
- C3 -
-
3WE8
1
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
68
Blastp_CBE
54.35
35%
-15
- C3 -
-
4LL5
5
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
----
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
117
Blastp_CBE
54.28
35%
-19
- C3 -
-
3QF9
1
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
41
Blastp_CBE
54.28
34%
-16
- C3 -
-
5EOL
3
PIM1_HUMAN
A:
[14-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
--
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
62
Blastp_CBE
54.27
35%
-22
- C3 -
-
1YXU
2
PIM1_HUMAN
B:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
59
Blastp_CBE
54.26
35%
-18
- C3 -
-
1YXV
2
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
115
Blastp_CBE
54.25
35%
-15
- C3 -
-
6PCW
3
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
-
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
292
Blastp_CBE
54.24
34%
-78
- C3 -
-
2JAM
3
KCC1G_HUMAN
B:
[14-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
-----------
S
S
L
E
N
----------------
E
I
A
V
L
K
K
I
K
----
H
--
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
-
V
S
G
G
E
L
F
D
R
I
----
L
E
R
-
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
LTP
E
---
E
----
N
S
-
K
----
I
M
I
T
D
F
G
L
S
K
-
M
-
E
Q
N
G
I
M
S
T
-
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
-----
Q
K
-----
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
-----
I
L
L
------
C
G
Y
P
P
F
-----
Y
--
E
ETESK-
L
F
E
--
K
I
-
K
E
---
G
Y
-
Y
EFE-
S
--
P
--
F
W
DD-------
I
----------
S
E
S
A
K
D
--------
F
I
C
H
--------
L
L
E
K
D
P
N
E
--
R
Y
-----
T
C
E
K
A
L
S
H
P
W
I
---------------------------------------------------------------------------------
55
Blastp_CBE
54.20
35%
-19
- C3 -
-
2O64
3
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
50
Blastp_CBE
54.19
35%
-18
- C3 -
-
5C1Q
1
PIM1_HUMAN
B:
[13-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
90
Blastp_CBE
54.18
35%
-18
- C3 -
-
5TEL
2
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
-
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
386
Blastp_CBE
54.17
31%
6
- C3 -
-
5AUX
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
--
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
86
Blastp_CBE
54.16
35%
-11
- C3 -
-
4K18
1
PIM1_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
36
Blastp_CBE
54.16
35%
-16
- C3 -
-
2XJ0
1
PIM1_HUMAN
A:
[25-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
138
Blastp_CBE
54.08
35%
-15
- C3 -
-
5N4O
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
--
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
406
Blastp_CBE
54.07
31%
13
- C3 -
-
6QMO
7
DAPK1_HUMAN
A:
[16-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
364
Blastp_CBE
54.03
31%
7
- C3 -
-
4PF4
6
DAPK1_HUMAN
A:
[14-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
385
Blastp_CBE
53.97
31%
3
- C3 -
-
5AUY
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
--
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
241
Blastp_CBE
53.94
34%
6
- C3 -
-
5VJA
2
DAPK3_HUMAN
C:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
R
-----------
L
S
S
---
G
VSRE
E
I
E
--
R
--
E
V
N
I
L
R
E
I
R
----
H
--
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
------
E
K
-
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
VP--
N
P
-
R
----
I
K
L
I
D
F
G
I
A
H
K
I
-
E
A
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GE
T
------
K
Q
E
--
T
L
-
T
N
---
I
S
-
A
----
V
--
N
--
Y
D
---------
F
----------
D
E
E
Y
F
S
NTSELAKD
F
I
R
R
--------
L
L
V
K
D
P
K
R
--
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
---------------------------------------------------------------------------------
76
Blastp_CBE
53.94
35%
-20
- C3 -
-
3VBY
3
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
----
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
103
Blastp_CBE
53.92
35%
-14
- C3 -
-
3C4E
2
PIM1_HUMAN
C:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
116
Blastp_CBE
53.87
35%
-17
- C3 -
-
4GW8
2
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
77
Blastp_CBE
53.86
35%
-21
- C3 -
-
3VBX
1
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
---
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
73
Blastp_CBE
53.85
35%
-17
- C3 -
-
3UIX
2
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
---
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
100
Blastp_CBE
53.80
35%
-10
- C3 -
-
6NO8
1
?
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
89
Blastp_CBE
53.77
35%
-15
- C3 -
-
5TEX
2
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
131
Blastp_CBE
53.75
35%
-13
- C3 -
-
5N50
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
109
Blastp_CBE
53.75
35%
-16
- C3 -
-
3JXW
1
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
220
Blastp_CBE
53.73
31%
-35
- C3 -
-
6E4W
2
?
A:
[24-423]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
57
Blastp_CBE
53.72
35%
-16
- C3 -
-
2O3P
3
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
108
Blastp_CBE
53.68
35%
-15
- C3 -
-
3JY0
1
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
142
Blastp_CBE
53.65
35%
-12
- C3 -
-
2OI4
5
PIM1_HUMAN
X:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
139
Blastp_CBE
53.65
35%
-16
- C3 -
-
5N4N
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
54
Blastp_CBE
53.61
35%
-13
- C3 -
-
2O65
2
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
313
Blastp_CBE
53.60
35%
-84
- C3 -
-
2WTI
3
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------
P
A
L
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
300
Blastp_CBE
53.54
35%
-94
- C3 -
-
4BDE
5
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------
A
L
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
363
Blastp_CBE
53.51
31%
11
- C3 -
-
2W4J
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
379
Blastp_CBE
53.52
31%
2
- C3 -
-
5AV4
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
---
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
46
Blastp_CBE
53.51
35%
-14
- C3 -
-
3A99
1
PIM1_HUMAN
A:
[44-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
56
Blastp_CBE
53.50
35%
-15
- C3 -
-
2O63
4
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
141
Blastp_CBE
53.49
35%
-14
- C3 -
-
3BWF
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
401
Blastp_CBE
53.46
31%
12
- C3 -
-
2W4K
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
384
Blastp_CBE
53.43
31%
-1
- C3 -
-
5AUZ
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
---
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
145
Blastp_CBE
53.44
35%
-13
- C3 -
-
2BZJ
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
111
Blastp_CBE
53.43
35%
-20
- C3 -
-
6QXK
1
PIM1_HUMAN
B:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
--
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
80
Blastp_CBE
53.34
35%
-24
- C3 -
-
3VBT
1
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
----
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
105
Blastp_CBE
53.32
35%
-12
- C3 -
-
3C4E
2
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
33
Blastp_CBE
53.29
36%
-63
- C3 -
-
4X7Q
1
PIM2_HUMAN
A:
[33-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
----
R
L
Q
V
A
I
K
V
I
P
R
-----------------------------
L
--
E
V
A
L
L
W
K
V
-G---
H
--
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
----
T
E
K
-
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D--
L
---
R
----
R
G
-
C
----
A
K
L
I
D
F
G
S
G
A
--------------
D
G
T
R
V
Y
S
P
P
E
W
I
--
S
-----
R
H
-----
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
R
------
D
Q
E
--
I
L
-
E
A
---
E
L
-
H
----
F
--
P
--
A
H
---------
V
----------
S
P
D
C
C
A
--------
L
I
R
R
--------
C
L
A
P
K
P
S
S
--
R
P
-----
S
L
E
E
I
L
L
D
P
W
M
Q
--------------------------------------------------------------------------------
390
Blastp_CBE
53.25
31%
4
- C3 -
-
5AUT
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
---
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
101
Blastp_CBE
53.25
35%
-13
- C3 -
-
4K1B
1
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
527
HHSearch
53.23
34%
-2
- C3 -
-
6NO9
2
PIM1_HUMAN
A:
[3-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-
W
------
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
----
S
GF
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
L--
N
----
R
G
-
E
----
L
K
L
I
D
F
G
S
G
A
L
L
-
K
D
T
-
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
Q
D
V
L
-----------------------------------------------------------------------------
378
Blastp_CBE
53.14
31%
12
- C3 -
-
6AAR
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
------------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
402
Blastp_CBE
53.12
31%
17
- C3 -
-
4TXC
7
DAPK1_HUMAN
A:
[32-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
140
Blastp_CBE
53.14
35%
-15
- C3 -
-
5MZL
2
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
----
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
143
Blastp_CBE
53.13
35%
-18
- C3 -
-
2C3I
1
PIM1_HUMAN
B:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
---
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
99
Blastp_CBE
53.12
35%
-10
- C3 -
-
6NO9
2
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
449
Blastp_CBE
52.97
31%
-59
- C3 -
-
6MM7
9
KAPCA_MOUSE
D:
[31-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
----
K
Q
I
E
H
----------
T
--
L
N-
E
K
R
I
L
Q
A
V
N
----
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
-
Y
V
A
G
G
E
M
F
S
H
L
----
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
---
Q
----
Q
G
-
Y
----
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
G
R
T
W
T
--
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
-----
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
-----
E
M
A
AGYPPF
F
A
D
Q
P
I
-----
Q
--
I
------
Y
E
K
--
I
V
-
S
G
---
K
V
-
R
----
F
--
P
--
S
H
---------
F
----------
S
S
D
L
K
D
--------
L
L
R
N
--------
L
L
Q
----------------------------------------------------------------------------------------------------------
407
Blastp_CBE
53.00
31%
13
- C3 -
-
2Y0A
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
34
Blastp_CBE
52.97
36%
-32
- C3 -
-
2IWI
1
PIM2_HUMAN
B:
[29-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
E
A
E
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
--------------------------
T
CP
L
--
E
V
A
L
L
W
K
V
G
AGGG
H
--
P
G
V
I
R
L
L
D
W
F
E
----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
----
T
E
K
-
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D--
L
---
R
----
R
G
-
C
----
A
K
L
I
D
F
G
S
G
A
L
L
-
H
-
D
E
P
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
S
-----
R
H
-----
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
R
------
D
Q
E
--
I
L
-
E
A
---
E
L
-
H
----
F
--
P
--
A
H
---------
V
----------
S
P
D
C
C
A
--------
L
I
R
R
--------
C
L
A
P
K
P
S
S
--
R
P
-----
S
L
E
E
I
L
L
D
P
W
M
Q
--------------------------------------------------------------------------------
222
Blastp_CBE
52.90
31%
-35
- C3 -
-
6E4T
2
?
A:
[24-423]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
71
Blastp_CBE
52.88
35%
-18
- C3 -
-
3UMX
1
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
--
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
---------
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
303
Blastp_CBE
52.82
35%
-90
- C3 -
-
4BDB
10
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------
L
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
154
Blastp_CBE
52.82
35%
-20
- C3 -
-
2XJ2
1
PIM1_HUMAN
A:
[25-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
156
Blastp_CBE
52.80
35%
-22
- C3 -
-
2XIZ
1
PIM1_HUMAN
A:
[25-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
130
Blastp_CBE
52.78
35%
-17
- C3 -
-
5N52
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
-----
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
93
Blastp_CBE
52.75
35%
-16
- C3 -
-
4ALV
2
PIM1_HUMAN
A:
[52-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
312
Blastp_CBE
52.69
35%
-83
- C3 -
-
2WTJ
5
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------
P
A
L
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
383
Blastp_CBE
52.67
31%
4
- C3 -
-
5AV0
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
S
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
--
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
184
Blastp_CBE
52.66
35%
-18
- C3 -
-
3CY3
2
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
--
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
178
Blastp_CBE
52.60
35%
-19
- C3 -
-
4N6Z
4
PIM1_HUMAN
A:
[52-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
104
Blastp_CBE
52.59
35%
-12
- C3 -
-
3C4E
2
PIM1_HUMAN
B:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
412
Blastp_CBE
52.55
32%
-7
- C3 -
-
1PHK
1
PHKG1_RABIT
A:
[15-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
S
-
F
----
S
A
E
E
V
Q
E
L
R
----
E
A
T
--
L
K-
E
V
D
I
L
R
K
V
S
G---
H
--
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
-
E
L
F
D
Y
L
----
T
E
K
-
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
---
D
----
D
M
-
N
----
I
K
L
T
D
F
G
F
S
C
Q
L
-
D
P
G
E
K
L
R
E
-
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
--
E
CSMND
N
H
-----
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
-----
T
L
L
------
A
G
S
P
P
F
-----
W
--
H
------
R
K
Q
ML
M
L
-
R
M
---
I
M
-
S
----
G
--
N
--
Y
Q
---------
F
GSPEWDDY--
S
D
T
V
K
D
--------
L
V
S
R
--------
F
L
V
V
Q
P
Q
K
--
R
Y
-----
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
V
-----------------------------------------------------------------------------
451
Blastp_CBE
52.36
31%
-64
- C3 -
-
6MM6
1
KAPCA_MOUSE
E:
[31-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
----
K
Q
I
E
H
----------
T
--
L
N-
E
K
R
I
L
Q
A
V
N
----
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
-
Y
V
A
G
G
E
M
F
S
H
L
----
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
---
Q
----
Q
G
-
Y
----
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
G
R
T
W
T
--
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
-----
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
-----
E
M
A
AGYPPF
F
A
D
Q
P
I
-----
Q
--
I
------
Y
E
K
--
I
V
-
S
G
---
K
V
-
R
----
F
--
P
--
S
H
---------
F
----------
S
S
D
L
K
D
--------
L
L
R
N
--------
L
L
Q
----------------------------------------------------------------------------------------------------------
315
Blastp_CBE
52.31
35%
-85
- C3 -
-
2WTC
1
CHK2_HUMAN
A:
[17-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------
P
A
L
N
-----
V
E
--
T
--
E
I
E
I
L
K
K
L
N
----
H
--
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
-
E
L
F
D
K
V
----
V
G
N
-
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
SQE
E
----
D
C
-
L
----
I
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
-
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
-----
G
T
-----
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
-----
I
C
L
------
S
G
Y
P
P
F
-----
S
--
E
HRTQVS
L
K
D
--
Q
I
-
T
S
---
G
K
-
Y
----
N
FI
P
--
E
V
WAE------
V
----------
S
E
K
A
L
D
--------
L
V
K
K
--------
L
L
V
V
D
P
K
A
--
R
F
-----
T
T
E
E
A
L
R
H
P
W
L
---------------------------------------------------------------------------------
35
Blastp_CBE
52.23
36%
-30
- C3 -
-
2IWI
1
PIM2_HUMAN
A:
[33-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
L
G
P
L
L
G
K
G
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
N
R
V
L
---------------------
V
T
CP
L
--
E
V
A
L
L
W
K
V
G
AGGG
H
--
P
G
V
I
R
L
L
D
W
F
-----
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
----
T
E
K
-
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D--
L
---
R
----
R
G
-
C
----
A
K
L
I
D
F
G
S
G
A
L
L
-
H
-
D
E
P
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
S
-----
R
H
-----
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
R
------
D
Q
E
--
I
L
-
E
A
---
E
L
-
H
----
F
--
P
--
A
H
---------
V
----------
S
P
D
C
C
A
--------
L
I
R
R
--------
C
L
A
P
K
P
S
S
--
R
P
-----
S
L
E
E
I
L
L
D
P
W
M
Q
T
-------------------------------------------------------------------------------
185
Blastp_CBE
52.18
35%
-16
- C3 -
-
4A7C
2
PIM1_HUMAN
A:
[32-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
157
Blastp_CBE
52.18
35%
-20
- C3 -
-
2XIY
3
PIM1_HUMAN
A:
[25-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
158
Blastp_CBE
52.12
35%
-16
- C3 -
-
3F2A
1
PIM1_HUMAN
A:
[24-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
225
Blastp_CBE
52.00
31%
-36
- C3 -
-
5KQ5
2
?
A:
[24-410]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
244
Blastp_CBE
51.94
34%
-2
- C3 -
-
5A6O
2
DAPK3_HUMAN
B:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
R
-----------
L
S
S
S
R
R
G
VSRE
E
I
E
--
R
--
E
V
N
I
L
R
E
I
R
----
H
--
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
KNVP
N
P
-
R
----
I
K
L
I
D
F
G
I
A
H
K
I
-
E
-----
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GE
T
------
K
Q
E
--
T
L
-
T
N
---
I
S
-
A
----
V
--
N
--
Y
D
---------
F
----------
D
E
E
Y
F
S
NTSELAKD
F
I
R
R
--------
L
L
V
K
D
P
K
R
--
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
---------------------------------------------------------------------------------
221
Blastp_CBE
51.91
31%
-36
- C3 -
-
6E4U
2
AAPK1_RAT
A:
[24-408]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
227
Blastp_CBE
51.90
31%
-35
- C3 -
-
4QFR
2
?
A:
[24-423]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
223
Blastp_CBE
51.87
31%
-36
- C3 -
-
5UFU
2
AAPK1_MOUSE (first)
A:
[24-405]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
88
Blastp_CBE
51.85
35%
-15
- C3 -
-
4MBI
1
PIM1_HUMAN
A:
[9-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
239
Blastp_CBE
51.82
31%
-36
- C3 -
-
4CFH
1
AAPK1_RAT
A:
[41-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
411
Blastp_CBE
51.77
32%
-9
- C3 -
-
1QL6
1
PHKG1_RABIT
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
H
G
F
Y
---
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
S
-
F
----
S
A
E
E
V
Q
E
L
R
----
E
A
T
--
L
K-
E
V
D
I
L
R
K
V
S
G---
H
--
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
-
E
L
F
D
Y
L
----
T
E
K
-
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
---
D
----
D
M
-
N
----
I
K
L
T
D
F
G
F
S
C
Q
L
-
D
P
G
E
K
L
R
S
-
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
--
E
CSMND
N
H
-----
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
-----
T
L
L
------
A
G
S
P
P
F
-----
W
--
H
------
R
K
Q
ML
M
L
-
R
M
---
I
M
-
S
----
G
--
N
--
Y
Q
---------
F
GSPEWDDY--
S
D
T
V
K
D
--------
L
V
S
R
--------
F
L
V
V
Q
P
Q
K
--
R
Y
-----
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
V
-----------------------------------------------------------------------------
414
Blastp_CBE
51.68
32%
-12
- C3 -
-
2PHK
2
PHKG1_RABIT
A:
[2-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
Y
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
G
S
-
F
----
S
A
E
E
V
Q
E
L
R
----
E
A
T
--
L
K-
E
V
D
I
L
R
K
V
S
G---
H
--
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
-
E
L
F
D
Y
L
----
T
E
K
-
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
---
D
----
D
M
-
N
----
I
K
L
T
D
F
G
F
S
C
Q
L
-
D
P
G
E
K
L
R
E
-
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
--
E
CSMND
N
H
-----
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
-----
T
L
L
------
A
G
S
P
P
F
-----
W
--
H
------
R
K
Q
ML
M
L
-
R
M
---
I
M
-
S
----
G
--
N
--
Y
Q
---------
F
GSPEWDDY--
S
D
T
V
K
D
--------
L
V
S
R
--------
F
L
V
V
Q
P
Q
K
--
R
Y
-----
T
A
E
E
A
L
A
H
P
F
F
Q
Q
-------------------------------------------------------------------------------
144
Blastp_CBE
51.68
35%
-15
- C3 -
-
2BZK
1
PIM1_HUMAN
B:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
-----
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
112
Blastp_CBE
51.68
35%
-16
- C3 -
-
6PDP
1
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
--
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
194
Blastp_CBE
51.64
35%
-20
- C3 -
-
2XIX
1
PIM1_HUMAN
A:
[25-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
D
S
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
181
Blastp_CBE
51.58
35%
-14
- C3 -
-
3DCV
1
PIM1_HUMAN
A:
[52-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
78
Blastp_CBE
51.50
35%
-15
- C3 -
-
3VBW
1
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
----
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
---
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
224
Blastp_CBE
51.46
31%
-37
- C3 -
-
5T5T
2
AAPK1_RAT
A:
[24-405]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
155
Blastp_CBE
51.42
35%
-17
- C3 -
-
2XJ1
1
PIM1_HUMAN
A:
[25-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
174
Blastp_CBE
51.40
35%
-19
- C3 -
-
5IIS
2
PIM1_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
32
Blastp_CBE
51.36
36%
-23
- C3 -
-
4X7Q
1
PIM2_HUMAN
B:
[29-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
E
A
E
Y
R
L
G
P
L
L
G
K
-
G
F
G
T
V
F
A
G
H
R
L
T
D
R
L
Q
V
A
I
K
V
I
P
R
---------------------------CP
L
--
E
V
A
L
L
W
K
V
G
AGGG
H
--
P
G
V
I
R
L
L
D
W
F
E
T
---
F
M
L
V
L
E
R
P
L
P
A
Q
D
L
F
D
Y
I
----
T
E
K
-
G
P
L
G
E
G
P
S
R
C
F
F
G
Q
V
V
A
A
I
Q
H
C
H
S
R
G
V
V
H
R
D
I
K
D
E
N
I
L
I
D--
L
---
R
----
R
G
-
C
----
A
K
L
I
D
F
G
S
G
A
L
L
-
H
-
D
E
P
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
S
-----
R
H
-----
Q
Y
H
A
L
P
A
T
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
R
------
D
Q
E
--
I
L
-
E
A
---
E
L
-
H
----
F
--
P
--
A
H
---------
V
----------
S
P
D
C
C
A
--------
L
I
R
R
--------
C
L
A
P
K
P
S
S
--
R
P
-----
S
L
E
E
I
L
L
D
P
W
M
Q
--------------------------------------------------------------------------------
229
Blastp_CBE
51.35
31%
-37
- C3 -
-
4RER
2
AAPK1_HUMAN
A:
[14-352]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
187
Blastp_CBE
51.26
35%
-19
- C3 -
-
5N5L
2
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
-
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
228
Blastp_CBE
51.25
31%
-36
- C3 -
-
4QFG
1
AAPK1_RAT
A:
[24-503]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
176
Blastp_CBE
51.21
35%
-14
- C3 -
-
5DWR
1
PIM1_HUMAN
A:
[52-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
160
Blastp_CBE
51.18
35%
-17
- C3 -
-
4BZN
1
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
249
Blastp_CBE
51.17
34%
7
- C3 -
-
3BHY
1
DAPK3_HUMAN
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
R
-----------
L
S
S
S
R
R
G
VSRE
E
I
E
--
R
--
E
V
N
I
L
R
E
I
R
----
H
--
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
KNVP
N
P
-
R
----
I
K
L
I
D
F
G
I
A
H
K
I
-
E
----------
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GE
T
------
K
Q
E
--
T
L
-
T
N
---
I
S
-
A
----
V
--
N
--
Y
D
---------
F
----------
D
E
E
Y
F
S
NTSELAKD
F
I
R
R
--------
L
L
V
K
D
P
K
R
--
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
---------------------------------------------------------------------------------
159
Blastp_CBE
51.12
35%
-14
- C3 -
-
4BZO
1
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
165
Blastp_CBE
51.06
35%
-14
- C3 -
-
3BGQ
1
PIM1_HUMAN
A:
[57-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
245
Blastp_CBE
51.01
34%
9
- C3 -
-
5A6O
3
DAPK3_HUMAN
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
R
-----------
L
S
S
S
R
R
G
VSRE
E
I
E
--
R
--
E
V
N
I
L
R
E
I
R
----
H
--
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
KNVP
N
P
-
R
----
I
K
L
I
D
F
G
I
A
H
K
I
-
E
-----
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GE
T
------
K
Q
E
--
T
L
-
T
N
---
I
S
-
A
----
V
--
N
--
Y
D
---------
F
----------
D
E
E
Y
F
S
NTSELAKD
F
I
R
R
--------
L
L
V
K
D
P
K
R
--
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
---------------------------------------------------------------------------------
189
Blastp_CBE
50.97
35%
-17
- C3 -
-
2BZI
1
PIM1_HUMAN
B:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
186
Blastp_CBE
50.97
35%
-16
- C3 -
-
5N5M
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
191
Blastp_CBE
50.92
35%
-13
- C3 -
-
5O13
2
PIM1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
-
N
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
448
Blastp_CBE
50.86
31%
-59
- C3 -
-
6MM8
5
KAPCA_MOUSE
C:
[31-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
----
K
Q
I
E
H
----------
T
--
L
N-
E
K
R
I
L
Q
A
V
N
----
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
-
Y
V
A
G
G
E
M
F
S
H
L
----
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
---
Q
----
Q
G
-
Y
----
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
G
R
T
W
T
--
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
-----
S
K
-----
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
-----
E
M
A
AGYPPF
F
A
D
Q
P
I
-----
Q
--
I
------
Y
E
K
--
I
V
-
S
G
---
K
V
-
R
----
F
--
P
--
S
H
---------
F
----------
S
S
D
L
K
D
--------
L
L
R
N
--------
L
L
Q
----------------------------------------------------------------------------------------------------------
226
Blastp_CBE
50.83
31%
-34
- C3 -
-
4QFS
2
AAPK1_RAT
A:
[24-423]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
L
D
----
V
------
V
G
----
K
I
R
--
R
--
E
I
Q
N
L
K
L
F
R
----
H
--
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
-
Y
V
S
G
G
E
L
F
D
Y
I
----
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
---
A
----
H
M
-
N
----
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
E
-
F
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
-----
G
R
-----
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
-----
A
L
L
------
C
G
T
L
P
F
-----
D
--
D
DHVPTL
F
K
K
--
I
C
-
D
G
---
I
F
-
Y
----
T
--
P
--
Q
Y
---------
L
----------
N
P
S
V
I
S
--------
L
L
K
H
--------
M
L
Q
V
D
P
M
K
--
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
--
D
L
P
K
Y
L
F
P
E
--------------------------------------------------------------------
246
Blastp_CBE
50.73
34%
3
- C3 -
-
5A6N
1
DAPK3_HUMAN
B:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
R
-----------
L
S
S
S
R
R
G
VSRE
E
I
E
--
R
--
E
V
N
I
L
R
E
I
R
----
H
--
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
KNVP
N
P
-
R
----
I
K
L
I
D
F
G
I
A
H
K
I
-
E
-----
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GE
T
------
K
Q
E
--
T
L
-
T
N
---
I
S
-
A
----
V
--
N
--
Y
D
---------
F
----------
D
E
E
Y
F
S
NTSELAKD
F
I
R
R
--------
L
L
V
K
D
P
K
R
--
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
---------------------------------------------------------------------------------
167
Blastp_CBE
50.73
35%
-16
- C3 -
-
2OBJ
1
PIM1_HUMAN
A:
[57-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
172
Blastp_CBE
50.72
35%
-10
- C3 -
-
4MED
1
PIM1_HUMAN
A:
[13-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
113
Blastp_CBE
50.65
35%
-14
- C3 -
-
6PDO
1
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
----
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
248
Blastp_CBE
50.45
34%
6
- C3 -
-
3BQR
4
DAPK3_HUMAN
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
R
-----------
L
S
S
S
R
R
G
VSRE
E
I
E
--
R
--
E
V
N
I
L
R
E
I
R
----
H
--
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
KNVP
N
P
-
R
----
I
K
L
I
D
F
G
I
A
H
K
I
-
E
A
G
N
---
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GE
T
------
K
Q
E
--
T
L
-
T
N
---
I
S
-
A
----
V
--
N
--
Y
D
---------
F
----------
D
E
E
Y
F
S
NTSELAKD
F
I
R
R
--------
L
L
V
K
D
P
K
R
--
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
---------------------------------------------------------------------------------
166
Blastp_CBE
50.33
35%
-17
- C3 -
-
3BGP
1
PIM1_HUMAN
A:
[57-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
179
Blastp_CBE
50.17
35%
-15
- C3 -
-
4N6Y
1
PIM1_HUMAN
A:
[52-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
177
Blastp_CBE
50.02
35%
-17
- C3 -
-
4N70
1
PIM1_HUMAN
A:
[52-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
247
Blastp_CBE
49.74
34%
14
- C3 -
-
5A6N
4
DAPK3_HUMAN
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
R
R
-----------
L
S
S
S
R
R
G
VSRE
E
I
E
--
R
--
E
V
N
I
L
R
E
I
R
----
H
--
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
-
S
G
G
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
KNVP
N
P
-
R
----
I
K
L
I
D
F
G
I
A
H
K
I
-
E
A
G
N
E
F
K
N
-
I
-
F
G
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GE
T
------
K
Q
E
--
T
L
-
T
N
---
I
S
-
A
----
V
--
N
--
Y
D
---------
F
----------
D
E
E
Y
F
S
NTSELAKD
F
I
R
R
--------
L
L
V
K
D
P
K
R
--
R
M
-----
T
I
A
Q
S
L
E
H
S
W
I
---------------------------------------------------------------------------------
173
Blastp_CBE
49.54
35%
-15
- C3 -
-
4IAA
1
PIM1_HUMAN
A:
[13-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
183
Blastp_CBE
49.15
35%
-17
- C3 -
-
3MA3
1
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
--
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
163
Blastp_CBE
48.96
35%
-15
- C3 -
-
4XHK
1
PIM1_HUMAN
B:
[39-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
--------
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
188
Blastp_CBE
48.63
35%
-13
- C3 -
-
5N51
1
PIM1_HUMAN
A:
[37-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
----
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
250
Blastp_CBE
48.61
35%
-7
- C3 -
-
4ALU
2
PIM1_HUMAN
A:
[76-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
182
Blastp_CBE
47.61
35%
-14
- C3 -
-
6PDN
2
PIM1_HUMAN
A:
[38-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
----
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
N
C
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
G
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
-
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
370
Blastp_CBE
47.48
31%
10
- C3 -
-
3ZXT
1
DAPK1_HUMAN
A:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------------RE--
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
--
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
--------------
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
369
Blastp_CBE
46.75
31%
-2
- C3 -
-
3ZXT
1
DAPK1_HUMAN
B:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-----------
K
-
S
R
R
G
VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
K
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
------------
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
-
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
-----------
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
367
Blastp_CBE
46.26
31%
-8
- C3 -
-
3ZXT
1
DAPK1_HUMAN
D:
[13-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------------------VSRE
D
I
E
--
R
--
E
V
S
I
L
K
E
I
Q
----
H
--
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
-
E
L
F
D
F
L
----
A
E
-----
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
---
D
----
R
N
-
V
PKPR
I
K
I
I
D
F
G
L
A
H
K
I
-
D
------------
T
P
E
F
V
A
P
E
I
V
--
N
-----
Y
E
-----
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
-----
I
L
L
------
S
G
A
S
P
F
-----
L
GD
T
------
K
Q
E
--
T
L
-
A
N
---
V
S
-
A
----
V
--
N
--
Y
E
---------
F
----------
E
D
E
Y
F
S
--------
N
T
S
A
LAKDFIRR
L
L
V
K
D
P
K
K
--
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------
151
Blastp_CBE
45.49
35%
-3
- C3 -
-
5VUC
2
PIM1_HUMAN
B:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
-
N
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
152
Blastp_CBE
45.34
35%
-5
- C3 -
-
5VUB
2
PIM1_HUMAN
B:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
-
N
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
199
Blastp_CBE
44.59
35%
-7
- C3 -
-
1YHS
1
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
----
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
-
N
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
198
Blastp_CBE
44.01
35%
-6
- C3 -
-
1YI3
1
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
----
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
-
N
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
153
Blastp_CBE
43.69
35%
-8
- C3 -
-
4LM5
4
PIM1_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
----------
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
-
N
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
197
Blastp_CBE
42.51
35%
0
- C3 -
-
1YI4
1
PIM1_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
G
F
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
----
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
-
N
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
193
Blastp_CBE
42.22
35%
-2
- C3 -
-
5O11
4
PIM1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
G
--
G
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
N
G
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
-
N
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------
192
Blastp_CBE
41.77
35%
-3
- C3 -
-
5O12
2
PIM1_HUMAN
A:
[22-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
Q
V
G
P
L
L
G
S
----
S
V
Y
S
G
I
R
V
S
D
N
L
P
V
A
I
K
H
V
E
K
D
R
I
S
D
-------
W
G
E
L
P
--
T
----
R
V
P
--
M
--
E
V
V
L
L
K
K
V
S
SG--
F
--
S
G
V
I
R
L
L
D
W
F
E
R
P
D
S
F
V
L
I
L
E
R
P
E
P
V
Q
D
L
F
D
F
I
----
T
E
R
-
G
A
L
Q
E
E
L
A
R
S
F
F
W
Q
V
L
E
A
V
R
H
C
H
-
N
G
V
L
H
R
D
I
K
D
E
N
I
L
I
---
D
---
L
----
N
R
G
E
----
L
K
L
I
D
F
G
S
G
A
L
L
--
K
D
T
V
Y
T
D
-
F
-
D
G
T
R
V
Y
S
P
P
E
W
I
--
R
-----
Y
H
-----
R
Y
H
G
R
S
A
A
V
W
S
L
G
I
L
L
Y
-----
D
M
V
------
C
G
D
I
P
F
-----
E
--
H
------
D
E
E
--
I
I
-
R
G
---
Q
V
-
F
----
F
--
R
--
Q
R
---------
V
----------
S
S
E
C
Q
H
--------
L
I
R
W
--------
C
L
A
L
R
P
S
D
--
R
P
-----
T
F
E
E
I
Q
N
H
P
W
M
---------------------------------------------------------------------------------