@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ULK1_HUMAN: (2021-11-23 )
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTLPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHMLSDQADIENVTKCKLCIERRLSALLTGICA
Atome Classification :
(186 SA)
.........10...--.-----....20.........30........40........50..-.-------.----.--.-..-----60.---.-----......70........-.80---....------.-...-.90........100..-...-.----.---110.......120.......130.......140.......150.......160.......170..-.-.-.--...180.......190..------.---.--...200........210.......220...-----..-.-.-----230-------..-------------------.----..----.-.-240-...--.....250.......260.....----..270.......280.......290.........300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEPGRGGTETVGKF--E-----FSRKD-LIGH
G
A
F
A
V
V
FKGRHRE
K
H
D
L
E
V
A
V
K
C
I
N
K
K
NL-A-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L-KHE
N
I
V
A
L
-Y
D
----
F
Q
E
M------A-NS
V
-
Y
L
V
M
E
YCNG
G
D
L
A
D
Y
L
-
H
A
M
-
R
----T---L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
SKGIIHRDLKPQ
N
I
L
LSNPAGRRANP
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-S-N-M--
M
A
ATLCGSPMYM
A
P
E
V
I
M
------S---Q--HYDG-KA
D
L
W
S
I
G
T
I
V
Y
Q
C
LTGKAPFQASS-----P
Q
-
D
-
L
-----
R
L
F
-------
Y
E-------------------K----N
K
----
T
-L-VP--TIP--RETS
A
P
L
R
Q
L
L
L
A
L
L
QRNHKDRM----
D
F
D
E
F
FHHPFLDASPSVRKSPPV--PVPSYPSSGSGSSSSSSSTSHLASPPS
L
G
E
M
Q
Q
L
Q
K
T
LASPADTAG
F
L
HSSRDSGGSKDSSCDTD
D
F
V
M
V
PAQFP
G
D
L
V
AEAPSAKPPP
D
S
LMCSG
S
S
L
V
A
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPV
P
T
Q
V
Q
N
Y
Q
R
I
E
R
NLQSPTQFQT
P
R
S
S
A
I
RRSGSTSPLGFARASPSPPAHAEHGG
V
L
A
R
K
MSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGL
G
C
R
LHSAPNLS
D
L
H
VVRPKLPKPPTDPLGAVFSPPQASPPQP
S
H
G
L
Q
S
C
R
NLRGSPKL
P
D
F
L
QRNPLPPILGSPTKAVPSFDFPKTPSS
Q
N
L
L
A
L
L
A
RQ
G
V
V
MTPPRNRTLP
D
L
S
EVGPFHGQPLGPGLRPGEDPKGPFGRSF
S
T
S
R
L
T
D
L
L
L
K
A
AFGTQAPDPGS
T
E
S
L
Q
EKPMEIAPSAGFGGSLHPGARAGGTSSPS
P
V
V
F
TVGSPPSGSTPPQGPRT
R
M
FSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLE
G
A
V
T
FEAPDL
P
E
E
T
L
M
E
Q
E
H
T
E
I
L
R
G
L
R
F
T
L
L
F
V
Q
H
V
L
E
I
A
A
LKGSASEAAGGP
E
Y
Q
L
Q
E
S
V
V
A
D
Q
I
S
L
L
S
R
EWG
F
A
E
Q
L
V
L
Y
L
K
V
A
E
L
L
S
S
G
L
Q
S
A
I
D
Q
I
R
AG
K
L
C
L
S
S
T
V
K
Q
V
V
R
R
L
N
E
L
Y
K
A
S
VVSCQ
G
L
S
L
R
L
Q
R
F
F
L
D
K
Q
R
L
L
D
R
I
H
S
I
T
A
E
R
L
I
F
S
H
A
V
Q
M
V
Q
S
A
A
L
D
E
M
F
Q
H
REGC
V
P
R
Y
H
K
A
L
L
L
L
E
G
L
Q
H
M
LSDQA
D
I
E
N
V
T
K
C
K
L
C
I
E
R
R
L
S
A
L
L
T
G
ICA
4
PsiBlast_PDB
94.17
98%
-128
- C2 -
-
5CI7
4
ULK1_HUMAN
A:
[7-283]
--
P
G
R
G
G
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
N
P
A
G
R
R
A
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-
S
-
N
-
M
--
M
A
A
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
HHSearch
93.36
99%
-124
- C2 -
-
4WNO
1
ULK1_HUMAN
A:
[12-284]
-------
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
N
P
A
G
R
R
A
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-
S
-
N
-
M
--
M
A
A
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.13
98%
-124
- C2 -
-
4WNO
1
ULK1_HUMAN
A:
[12-284]
-------
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
N
P
A
G
R
R
A
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-
S
-
N
-
M
--
M
A
A
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.88
98%
-128
- C2 -
-
4WNP
3
ULK1_HUMAN
A:
[11-284]
------
G
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
N
P
A
G
R
R
A
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-
S
-
N
-
M
--
M
A
A
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
92.70
99%
-128
- C2 -
-
4WNP
1
ULK1_HUMAN
D:
[12-284]
-------
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
N
P
A
G
R
R
A
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-
S
-
N
-
M
--
M
A
A
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
92.29
99%
-132
- C2 -
-
4WNP
1
ULK1_HUMAN
C:
[12-283]
-------
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
N
P
A
G
R
R
A
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-
S
-
N
-
M
--
M
A
A
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
553
HHSearch
92.16
99%
-124
- C2 -
-
6QAS
15
ULK1_HUMAN
A:
[12-285]
-------
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
N
P
A
G
R
R
A
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-
S
-
N
-
M
--
M
A
A
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.13
98%
-135
- C2 -
-
6MNH
2
ULK1_HUMAN
A:
[5-287]
-------
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
E
K
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
---------
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
------------
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
A
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
A
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
A
S
P
S
V
R
K
S
P
P
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
92.07
99%
-125
- C2 -
-
4WNP
2
ULK1_HUMAN
B:
[12-284]
-------
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
N
P
A
G
R
R
A
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-
S
-
N
-
M
--
M
A
A
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.93
98%
-124
- C2 -
-
6QAS
15
ULK1_HUMAN
A:
[12-285]
-------
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
N
P
A
G
R
R
A
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-
S
-
N
-
M
--
M
A
A
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
91.55
99%
-128
- C2 -
-
6QAS
7
ULK1_HUMAN
B:
[12-284]
-------
T
E
T
V
G
K
F
--
E
-----
F
S
R
K
D
-
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
-
A
-------
K
----
S
--
Q
-
T
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
K
H
E
N
I
V
A
L
-
Y
D
----
F
Q
E
M
------
A
-
N
S
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
-
R
----
T
---
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
N
P
A
G
R
R
A
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
-
Y
L
Q
-
S
-
N
-
M
--
M
A
A
T
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
G
-
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
-----
P
Q
-
D
-
L
-----
R
L
F
-------
Y
E
-------------------
K
----
N
K
----
T
-
L
-
V
P
--
T
I
P
--
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
----
D
F
D
E
F
F
H
H
P
F
L
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.13
76%
-147
- C2 -
-
6QAU
6
ULK2_HUMAN
A:
[4-279]
------
S
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
N
R
R
K
S
S
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
-
S
-
N
-
M
--
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
S
-----
P
Q
-
D
-
L
-----
R
M
F
-------
Y
E
-------------------
K
----
N
R
----
S
-
L
-
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
Q
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.78
76%
-148
- C2 -
-
6QAV
6
ULK2_HUMAN
A:
[4-276]
------
S
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
N
R
R
K
S
S
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
-
S
-
N
-
M
--
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
S
-----
P
Q
-
D
-
L
-----
R
M
F
-------
Y
E
-------------------
K
----
N
R
----
S
-
L
-
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
85.64
77%
-142
- C2 -
-
6QAV
6
ULK2_HUMAN
C:
[5-279]
-------
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
N
R
R
K
S
S
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
-
S
-
N
-
M
--
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
S
-----
P
Q
-
D
-
L
-----
R
M
F
-------
Y
E
-------------------
K
----
N
R
----
S
-
L
-
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
Q
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
555
HHSearch
85.40
77%
-154
- C2 -
-
6QAU
6
ULK2_HUMAN
A:
[7-278]
---------
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
N
R
R
K
S
S
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
-
S
-
N
-
M
--
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
S
-----
P
Q
-
D
-
L
-----
R
M
F
-------
Y
E
-------------------
K
----
N
R
----
S
-
L
-
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
Q
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
85.15
77%
-149
- C2 -
-
6QAU
5
ULK2_HUMAN
B:
[4-278]
------
S
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
N
R
R
K
S
S
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
---------------
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
S
-----
P
Q
-
D
-
L
-----
R
M
F
-------
Y
E
-------------------
K
----
N
R
----
S
-
L
-
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
Q
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
85.10
77%
-148
- C2 -
-
6QAV
7
ULK2_HUMAN
B:
[4-277]
------
S
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
-----
S
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
-
S
-
N
-
M
--
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
S
-----
P
Q
-
D
-
L
-----
R
M
F
-------
Y
E
-------------------
K
----
N
R
----
S
-
L
-
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
81.52
77%
-156
- C2 -
-
6QAT
1
ULK2_HUMAN
D:
[5-274]
-------
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
------
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
-----------------
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
S
-----
P
Q
-
D
-
L
-----
R
M
F
-------
Y
E
-------------------
K
----
N
R
----
S
-
L
-
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.08
76%
-151
- C2 -
-
6QAT
1
ULK2_HUMAN
A:
[5-278]
-------
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
N
-----
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
---------------
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
S
-----
P
Q
-
D
-
L
-----
R
M
F
-------
Y
E
-------------------
K
----
N
R
----
S
-
L
-
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
Q
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
80.85
77%
-153
- C2 -
-
6QAT
2
ULK2_HUMAN
C:
[4-277]
------
S
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
-------
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
---------------
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
A
N
S
-----
P
Q
-
D
-
L
-----
R
M
F
-------
Y
E
-------------------
K
----
N
R
----
S
-
L
-
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
80.10
77%
-153
- C2 -
-
6QAU
5
ULK2_HUMAN
C:
[3-277]
-----
G
S
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
----------------------
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
N
R
R
K
S
S
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
-
S
-------------
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
---------------------
F
-------
Y
E
-------------------
K
----
N
R
----
S
-
L
-
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
79.71
77%
-145
- C2 -
-
6QAV
5
ULK2_HUMAN
D:
[5-276]
-------
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
N
R
R
K
S
S
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
-
S
-
N
-
M
--
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
Q
------------------------------------------------------------------
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
76.71
77%
-152
- C2 -
-
6QAT
1
ULK2_HUMAN
B:
[1-278]
---
G
G
G
S
M
E
V
V
G
D
F
--
E
-----
Y
S
K
R
D
-
L
V
G
H
G
A
F
A
V
V
F
R
G
R
H
R
Q
K
T
D
W
E
V
A
I
K
S
I
N
K
K
N
L
-
S
-------
K
----
S
--
Q
-
I
L
-----
L
G
K
---
E
-----
I
K
I
L
K
E
L
-
Q
H
E
N
I
V
A
L
-
Y
D
----
V
Q
E
L
------
P
-
N
S
V
-
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
-
G
----
T
---
L
S
E
D
T
I
R
V
F
L
H
Q
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
Y
A
N
-----
V
S
G
I
R
I
K
I
A
D
F
G
F
A
R
-
Y
L
H
---------------
S
P
M
Y
M
A
P
E
V
I
M
------
S
---
Q
--
H
Y
D
A
-
K
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
F
------------------------------------------------------------------
M
P
--
S
I
P
--
R
E
T
S
P
Y
L
A
N
L
L
L
G
L
L
Q
R
N
Q
K
D
R
M
----
D
F
E
A
F
F
S
H
P
F
L
E
Q
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
570
HHSearch
61.17
41%
-49
- C2 -
-
6FDY
2
ULK3_HUMAN
U:
[8-271]
--------
P
R
L
D
G
F
--
I
-----
L
--
T
E
-
R
L
G
-----
T
V
Y
K
A
Y
A
K
K
D
T
R
E
V
V
A
I
K
C
V
A
K
K
S
L
-
N
K------
A
----
S
--
V
-
E
N
-----
L
L
T
---
E
-----
I
E
I
L
K
G
I
-
R
H
P
H
I
V
Q
L
-
K
D
----
F
Q
W
D
------
S
-
D
N
I
-
Y
L
I
M
E
F
C
A
G
G
D
L
S
R
F
I
-
H
T
R
-
R
----
I
---
L
P
E
K
V
A
R
V
F
M
Q
Q
L
A
S
A
L
Q
F
L
H
E
R
N
I
S
H
L
D
L
K
P
Q
N
I
L
L
S
S
L
-------
E
K
P
H
L
K
L
A
D
F
G
F
A
Q
-
H
M
S
-
P
-
W
-
D
--
E
K
H
V
L
R
G
S
P
L
Y
M
A
P
E
M
V
C
------
Q
---
R
--
Q
Y
D
A
-
R
V
D
L
W
S
M
G
V
I
L
Y
E
A
L
F
G
Q
P
P
F
A
S
R
S
-----
F
S
-
E
-
L
-----
E
E
K
-------
I
R
-------------------
S
----
N
R
----
V
-
I
-
E
L
--
P
L
R
--
P
L
L
S
R
D
C
R
D
L
L
Q
R
L
L
E
R
D
P
S
R
R
I
----
S
F
Q
D
F
F
A
H
P
W
V
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
61.12
33%
-118
- C2 -
-
4BFM
1
MELK_MOUSE
A:
[15-263]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
A
L
-
G
-------
S
----
D
--
L
-
P
R
-----
V
K
T
---
E
-----
I
D
A
L
K
S
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
K
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
---------
E
N
H
K
L
K
L
I
D
F
G
L
C
A
-
K
---------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
----------------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
E
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
R
N
L
L
N
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
60.79
33%
-110
- C2 -
-
6T6F
1
?
A:
[16-296]
-------------
F
--
E
-----
F
--
K
E
-
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
-
F
A
V
K
C
I
P
K
K
A
L
-
K
-------
G
----
K
--
E
-
S
S
-----
I
E
N
---
E
-----
I
A
V
L
R
K
I
-
K
H
E
N
I
V
A
L
-
E
D
----
I
Y
E
S
------
P
-
N
H
L
-
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
-
G
----
F
---
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
------
Y
S
Q
D
E
E
S
K
I
M
I
S
D
F
G
L
S
---------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
--
P
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
DSKLF
E
Q
-
I
-
L
-----
K
A
E
-------
Y
E
-------------------
F
----
D
S
----
P
-
Y
-
W
D
--
D
I
------
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
----
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
A
L
N
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
60.54
33%
-116
- C2 -
-
4CQG
1
MELK_MOUSE
A:
[15-263]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
A
L
-
G
-------
S
----
D
--
L
-
P
R
-----
V
K
T
---
E
-----
I
D
A
L
K
S
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
K
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
---------
E
N
H
K
L
K
L
I
D
F
G
L
C
A
-
K
---------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
----------------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
E
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
R
N
L
L
N
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
59.87
33%
-119
* C2 *
-
4UMQ
1
MELK_HUMAN
A:
[31-283]
----------------------
Y
E
L
H
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
-------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
T
-----
A
A
-
A
-
L
-----
V
A
K
-------
I
M
-------------------
R
----
G
K
----
Y
-
D
-
V
P
--
K
W
L
--
S
P
S
S
I
L
L
L
Q
---
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
59.70
33%
-108
- C2 -
-
6T6F
1
?
B:
[16-296]
-------------
F
--
E
-----
F
--
K
E
-
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
-
F
A
V
K
C
I
P
K
K
A
L
-
K
-------
G
----
K
--
E
-
S
S
-----
I
E
N
---
E
-----
I
A
V
L
R
K
I
-
K
H
E
N
I
V
A
L
-
E
D
----
I
Y
E
S
------
P
-
N
H
L
-
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
-
G
----
F
---
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
------
Y
S
Q
D
E
E
S
K
I
M
I
S
D
F
G
-----------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
--
P
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
DSKLF
E
Q
-
I
-
L
-----
K
A
E
-------
Y
E
-------------------
F
----
D
S
----
P
-
Y
-
W
D
--
D
I
------
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
----
T
C
E
Q
A
A
R
H
P
W
I
A
G
D
T
A
L
N
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
59.64
35%
-97
- C2 -
-
2JAM
3
KCC1G_HUMAN
A:
[15-273]
--------------------------
E
-
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
-
F
A
L
K
C
I
-
K
K
---------------------
S
S
-----
L
E
N
---
E
-----
I
A
V
L
K
K
I
-
K
H
E
N
I
V
T
L
-
E
D
----
I
Y
E
S
------
T
-
T
H
Y
-
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
L
E
R
-
G
----
V
---
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-----
E
E
N
S
-
K
I
M
I
T
D
F
G
L
S
K
-
M
E
Q
-
N
-
G
-
I
--
M
-
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
--
P
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-----
E
S
-
K
-
L
---------------
F
E
-------------------
K
----
I
K
EGYY
E
-
F
-
E
S
--
P
F
W
--
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
----
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
59.50
35%
-92
- C2 -
-
2JAM
3
KCC1G_HUMAN
B:
[15-273]
--------------------------
E
-
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
-
F
A
L
K
C
I
-
K
K
---------------------
S
S
-----
L
E
N
---
E
-----
I
A
V
L
K
K
I
-
K
H
E
N
I
V
T
L
-
E
D
----
I
Y
E
S
------
T
-
T
H
Y
-
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
L
E
R
-
G
----
V
---
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-----
E
E
N
S
-
K
I
M
I
T
D
F
G
L
S
K
-
M
E
Q
-
N
-
G
-
I
--
M
-
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
--
P
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
-----
E
S
-
K
-
L
---------------
F
E
-------------------
K
----
I
K
EGYY
E
-
F
-
E
S
--
P
F
W
--
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
----
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
59.49
34%
-119
- C2 -
-
5TWL
1
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
-------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
59.43
34%
-114
- C2 -
-
5TVT
1
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
----------------
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
59.34
34%
-117
- C2 -
-
5IH9
1
MELK_HUMAN
A:
[14-262]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
------------------
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
59.18
34%
-123
- C2 -
-
5MAI
2
MELK_HUMAN
A:
[16-266]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
-----------------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.15
40%
-47
- C2 -
-
6FDY
2
ULK3_HUMAN
U:
[13-270]
----------------------
F
I
L
T
E
-
R
L
G
-----
T
V
Y
K
A
Y
A
K
K
D
T
R
E
V
V
A
I
K
C
V
A
K
K
S
L
-
N
-------
K
----
A
--
S
-
V
E
N----
L
L
T
---
E
-----
I
E
I
L
K
G
I
-
R
H
P
H
I
V
Q
L
-
K
D
----
F
Q
W
D
------
S
-
D
N
I
-
Y
L
I
M
E
F
C
A
G
G
D
L
S
R
F
I
-
H
T
R
-
R
----
I
---
L
P
E
K
V
A
R
V
F
M
Q
Q
L
A
S
A
L
Q
F
L
H
E
R
N
I
S
H
L
D
L
K
P
Q
N
I
L
L
S
S
L
----
E
K
P
H
---
L
K
L
A
D
F
G
F
A
Q
-
H
M
S
-
P
-
W
-
D
--
E
K
H
V
L
R
G
S
P
L
Y
M
A
P
E
M
V
C
------
Q
---
R
--
Q
Y
D
A
-
R
V
D
L
W
S
M
G
V
I
L
Y
E
A
L
F
G
Q
P
P
F
A
S
R
S
-----
F
S
-
E
-
L
-----
E
E
K
-------
I
R
-------------------
S
----
N
R
----
V
-
I
-
E
L
--
P
L
R
--
P
L
L
S
R
D
C
R
D
L
L
Q
R
L
L
E
R
D
P
S
R
R
I
----
S
F
Q
D
F
F
A
H
P
W
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
58.67
33%
-119
- C2 -
-
4UMU
1
MELK_HUMAN
A:
[31-283]
----------------------
Y
E
L
H
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
-------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
T
-----
A
A
-
A
-
L
-----
V
A
K
-------
I
M
-------------------
R
----
G
K
----
Y
-
D
-
V
P
--
K
W
L
--
S
P
S
S
I
L
L
L
Q
---
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
571
HHSearch
58.66
41%
-42
- C2 -
-
6FDZ
1
ULK3_HUMAN
U:
[7-271]
------
P
-
P
R
L
D
G
F
--
I
-----
L
--
T
E
-
R
L
G
S
G
T
Y
A
T
V
Y
K
A
Y
A
K
K
D
T
R
E
V
V
A
I
K
C
V
A
K
K
S
L
-
N
K------
A
----
S
--
V
-
E
N
-----
L
L
T
---
E
-----
I
E
I
L
K
G
I
-
R
H
P
H
I
V
Q
L
-
K
D
----
F
Q
W
D
------
S
-
D
N
I
-
Y
L
I
M
E
F
C
A
G
G
D
L
S
R
F
I
-
H
T
R
-
R
----
I
---
L
P
E
K
V
A
R
V
F
M
Q
Q
L
A
S
A
L
Q
F
L
H
E
R
N
I
S
H
L
D
L
K
P
Q
N
I
L
L
S
S
L
-------
E
K
P
H
L
K
L
A
D
F
G
F
A
Q
-
H
M
S
-
P
-
W
-
D
--
E
K
H
V
L
R
G
S
P
L
Y
M
A
P
E
M
V
C
-------------
Q
Y
D
A
-
R
V
D
L
W
S
M
G
V
I
L
Y
E
A
L
F
G
Q
P
P
F
A
S
R
S
-----
F
S
-
E
-
L
-----
E
E
K
-------
I
R
-------------------
S
----
N
R
----
V
-
I
-
E
L
--
P
L
R
--
P
L
L
S
R
D
C
R
D
L
L
Q
R
L
L
E
R
D
P
S
R
R
I
----
S
F
Q
D
F
F
A
H
P
W
V
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
58.50
34%
-115
- C2 -
-
5MAF
2
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
--------------
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
----
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
58.48
34%
-87
- C2 -
-
2YIQ
1
CHK2_HUMAN
A:
[11-286]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
----
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------------------------
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
58.41
33%
-123
- C2 -
-
4UMT
2
MELK_HUMAN
A:
[31-283]
----------------------
Y
E
L
H
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
-------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
T
-----
A
A
-
A
-
L
-----
V
A
K
-------
I
M
-------------------
R
----
G
K
----
Y
-
D
-
V
P
--
K
W
L
--
S
P
S
S
I
L
L
L
Q
---
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
58.25
34%
-121
- C2 -
-
5MAH
2
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
----
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
58.15
34%
-121
- C2 -
-
4BKY
1
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
--------------
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
57.60
34%
-128
- C2 -
-
5TWY
1
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
---------------
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
-------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
57.59
31%
-100
- C2 -
-
4FG8
1
KCC1A_HUMAN
B:
[23-285]
-------------------------
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
-
V
A
I
K
C
I
A
K
-------------------------------
N
---
E
-----
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
-
D
D
----
I
Y
E
S
------
G
-
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-----
L
D
E
D
S
-
K
I
M
I
S
D
F
G
----------
G
-
S
--
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
--
P
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
--------
D
-
A
-----
K
L
F
EQILKAE
Y
E
-------------------
F
----
D
S
----
P
-
Y
-
W
D
--
D
I
------
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
57.46
34%
-31
- C2 -
-
2YCF
1
CHK2_HUMAN
A:
[11-286]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
57.34
34%
-117
- C2 -
-
5IH8
1
MELK_HUMAN
A:
[14-262]
--------------------------
E
-
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
---------------
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
56.87
34%
-94
- C2 -
-
6GVX
3
MELK_HUMAN
A:
[19-274]
--------------------------
E
-
T
I
G
T
--
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
---------------
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K--------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.84
40%
-42
- C2 -
-
6FDZ
1
ULK3_HUMAN
U:
[13-270]
----------------------
F
I
L
T
E
-
R
L
G
S
G
T
Y
A
T
V
Y
K
A
Y
A
K
K
D
T
R
E
V
V
A
I
K
C
V
A
K
K
S
L
-
N
-------
K
----
A
--
S
-
V
E
N----
L
L
T
---
E
-----
I
E
I
L
K
G
I
-
R
H
P
H
I
V
Q
L
-
K
D
----
F
Q
W
D
------
S
-
D
N
I
-
Y
L
I
M
E
F
C
A
G
G
D
L
S
R
F
I
-
H
T
R
-
R
----
I
---
L
P
E
K
V
A
R
V
F
M
Q
Q
L
A
S
A
L
Q
F
L
H
E
R
N
I
S
H
L
D
L
K
P
Q
N
I
L
L
S
S
L
----
E
K
P
H
---
L
K
L
A
D
F
G
F
A
Q
-
H
M
S
-
P
-
W
-
D
--
E
K
H
V
L
R
G
S
P
L
Y
M
A
P
E
M
V
C
-------------
Q
Y
D
A
-
R
V
D
L
W
S
M
G
V
I
L
Y
E
A
L
F
G
Q
P
P
F
A
S
R
S
-----
F
S
-
E
-
L
-----
E
E
K
-------
I
R
-------------------
S
----
N
R
----
V
-
I
-
E
L
--
P
L
R
--
P
L
L
S
R
D
C
R
D
L
L
Q
R
L
L
E
R
D
P
S
R
R
I
----
S
F
Q
D
F
F
A
H
P
W
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
56.69
34%
-115
- C2 -
-
5MAG
3
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
--------------
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
----
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
56.59
34%
-27
- C2 -
-
2CN5
1
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
-----------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
56.48
34%
-24
- C2 -
-
2XK9
1
CHK2_HUMAN
A:
[10-285]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
G
A
-
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
56.42
34%
-119
- C2 -
-
5M5A
1
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
----
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
56.20
34%
-124
- C2 -
-
5IHC
1
MELK_HUMAN
A:
[14-262]
--------------------------
E
-
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
----------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
56.19
34%
-20
- C2 -
-
2W7X
3
CHK2_HUMAN
A:
[11-286]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
G
A
-
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
56.17
33%
-107
- C2 -
-
2R5T
1
SGK1_HUMAN
A:
[39-297]
----------------
D
-----
F
H
F
L
K
-
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
E
-
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
-
L
-------------------------------------
V
L
L
K
N
V
-
K
H
P
F
L
V
G
L
-
H
F
----
S
F
Q
T
------
A
-
D
K
L
-
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
-
Q
R
E
-
R
----
C
---
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
---------
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
-
H
-
N
-
S
--
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
------
K
---
Q
--
P
Y
D
R
-
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
-----
T
A
-
E
-
M
---------------
Y
D
-------------------
N
IL--
N
K
PL--
Q
-
L
-
K
P
--
N
I
T
--
N
S
A
----
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
GAKD
D
F
M
E
I
K
S
H
V
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
56.15
34%
-23
- C2 -
-
2YCQ
1
CHK2_HUMAN
A:
[11-286]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
56.08
34%
-114
- C2 -
-
5K00
1
MELK_HUMAN
A:
[14-262]
--------------------------
E
-
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
P
----------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
55.98
34%
-125
- C2 -
-
5TX3
2
MELK_HUMAN
A:
[19-267]
--------------------------
E
-
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
----------------------------
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
--------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
55.98
34%
-121
- C2 -
-
5IHA
1
MELK_HUMAN
A:
[14-262]
--------------------------
E
-
T
I
G
----
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
--------------------
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
55.83
34%
-113
- C2 -
-
6GVX
2
MELK_HUMAN
B:
[19-267]
--------------------------
E
-
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
----------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
P
---------------
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
55.78
34%
-122
- C2 -
-
5TWZ
1
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-
G
-------
S
----
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
---------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
--
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
55.26
34%
-115
- C2 -
-
4BL1
1
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-----------------
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
54.63
33%
-20
- C2 -
-
6GR9
1
AURKC_HUMAN
A:
[6-272]
-------
R
R
L
V
D
D
F
--
E
-----
I
G
R
P
---
L
G
K
G
K
F
G
N
V
Y
L
A
R
L
K
E
S
H
F
I
-
V
A
L
K
V
L
F
K
S
Q
I
-
E
-------
K
----
E
GL
E
-
H
Q
-----
L
R
R
---
E
-----
I
E
I
Q
A
H
L
-
Q
H
P
N
I
L
R
L
-
Y
N
----
Y
F
H
D
------
A
-
R
R
V
-
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
-
Q
K
S
-
D
----
K
---
L
D
E
Q
R
T
A
T
I
I
E
E
L
A
D
A
L
T
Y
C
H
D
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
----
G
F
R
G
-----
E
V
K
I
A
D
F
G
W
S
V
-
H
T
P
-
S
------
L
R
R
K
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
------
G
---
R
--
T
Y
D
E
-
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
Y
P
P
F
E
S
A
S
-----
H
S
-
E
-
T
---------------
Y
R
-------------------
R
----
I
L
----
K
-
V
-
D
V
--
R
F
P
--
L
S
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
R
L
----
P
L
A
Q
I
L
K
H
P
W
V
Q
A
H
-
S
R
R
V
L
P
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
54.58
34%
-124
- C2 -
-
4BKZ
1
MELK_HUMAN
A:
[16-264]
--------------------------
E
-
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
T
L
-----------------
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
---------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
54.45
31%
-110
- C2 -
-
4FG7
1
KCC1A_HUMAN
A:
[23-277]
-------------------------
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
-
V
A
I
K
C
I
A
------------------------
S
-----
M
E
N
---
E
-----
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
-
D
D
----
I
Y
E
S
------
G
-
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-----
L
D
E
D
S
-
K
I
M
I
S
D
F
G
L
S
K
-
M
E
D
-
P
------------
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
----
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
--------
D
-
A
-----
K
L
F
EQILKAE
Y
E
-------------------
F
----
D
S
----
P
-
Y
-
W
D
--
D
I
------
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
A
L
Q
H
P
W
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
54.28
34%
-23
- C2 -
-
4BDH
4
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
------
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
54.08
34%
-26
- C2 -
-
2YCS
1
CHK2_HUMAN
A:
[11-286]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
---
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
----
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
53.84
31%
-109
- C2 -
-
4FG9
1
KCC1A_HUMAN
B:
[23-285]
-------------------------
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
-
V
A
I
K
C
I
A
K
-----------------------------------
E
-----
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
-
D
D
----
I
Y
E
S
------
G
-
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-----
L
D
E
D
S
-
K
I
M
I
S
D
F
----------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
--
P
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
--------
D
-
A
-----
K
L
F
EQILKAE
Y
E
-------------------
F
----
D
S
----
P
-
Y
-
W
D
--
D
I
------
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
53.81
33%
-3
- C2 -
-
2WTW
1
AURKA_HUMAN
A:
[21-270]
-----------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
-
L
A
L
K
V
L
F
K
A
Q
L
-
E
-------
K
----
A
GV
E
-
H
Q
-----
L
R
R
---
E
-----
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
-
Y
G
----
Y
F
H
D
------
A
-
T
R
V
-
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
-
Q
K
L
-
S
----
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
--------
E
L
K
I
A
D
F
G
W
S
V
-
H
A
P
-
S
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
------
G
---
R
--
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
-----
Y
Q
-
E
-
T
---------------
Y
K
-------------------
R
----
I
S
----
R
-
V
-
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
53.75
33%
-8
- C2 -
-
4DEB
3
AURKA_HUMAN
A:
[17-266]
-----------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
-
L
A
L
K
V
L
F
K
A
Q
L
-
E
-------
K
----
A
GV
E
-
H
Q
-----
L
R
R
---
E
-----
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
-
Y
G
----
Y
F
H
D
------
A
-
T
R
V
-
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
-
Q
K
L
-
S
----
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
--------
E
L
K
I
A
D
F
G
W
S
V
-
H
A
P
-
S
-
S
----
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
------
G
---
R
--
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
-----
Y
Q
-
E
-
T
---------------
Y
K
-------------------
R
----
I
S
----
R
-
V
-
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
53.43
34%
-19
- C2 -
-
4BDG
2
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
---
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
53.39
34%
-118
- C2 -
-
5TWY
1
MELK_HUMAN
B:
[16-264]
--------------------------
E
-
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
N
----------------
D
--
L
-
P
R
-----
I
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
F
G
L
C
---------------------
L
A
Y
A
A
P
E
L
I
Q
------
G
---
K
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
53.08
34%
-19
- C2 -
-
4BDJ
1
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
-----
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
--
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
52.94
33%
-6
- C2 -
-
2W4J
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
52.88
33%
-7
- C2 -
-
4PF4
6
DAPK1_HUMAN
A:
[20-276]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
52.83
33%
-6
- C2 -
-
5AUT
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
---
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
52.82
34%
-25
- C2 -
-
4BDD
3
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
------
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
----
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
52.74
34%
-24
- C2 -
-
4BDF
3
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
----
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
52.63
34%
2
- C2 -
-
2YIR
1
CHK2_HUMAN
A:
[11-286]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------LN---
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
52.59
35%
-23
- C2 -
-
5EAK
1
MARK2_HUMAN
A:
[23-287]
-----------------------------
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
-------
S
----
S
--
L
-
Q
K
-----
L
F
R
---
E
-----
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
-
F
E
----
V
I
E
T
------
E
-
K
T
L
-
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
-
G
----
R
---
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---------
A
D
M
N
I
K
I
A
D
F
G
F
S
-----------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
------
G
---
K
--
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
-----
L
K
-
E
-
L
-----
R
E
R
-------
V
L
-------------------
R
----
G
K
----
Y
-------
R
I
P
--
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
VE
P
L
P
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
52.52
31%
-103
- C2 -
-
4FG8
1
KCC1A_HUMAN
A:
[23-285]
-------------------------
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
-
V
A
I
K
C
I
A
K
------------------------------
E
N
---
E
-----
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
-
D
D
----
I
Y
E
S
------
G
-
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-----
L
D
E
D
S
-
K
I
M
I
S
D
F
-----------------------
T
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
--
P
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
--------
D
-
A
-----
K
L
F
EQILKAE
Y
E
-------------------
F
----
D
S
----
P
-
Y
-
W
D
--
D
I
------
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
52.51
36%
-21
- C2 -
-
5KZ8
1
MARK2_HUMAN
A:
[41-305]
-----------------------------
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
-------
S
----
S
--
L
-
Q
K
-----
L
F
R
---
E
-----
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
-
F
E
----
V
I
E
T
------
E
-
K
T
L
-
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
-
G
----
R
---
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---------
A
D
M
N
I
K
I
A
D
F
G
--------------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
------
G
---
K
--
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
-----
L
K
-
E
-
L
-----
R
E
R
-------
V
L
-------------------
R
----
G
K
----
Y
-------
R
I
P
--
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
VE
P
L
P
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
52.38
33%
-8
- C2 -
-
3UP2
3
AURKA_HUMAN
A:
[17-266]
-----------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
-
L
A
L
K
V
L
F
K
A
Q
L
-
E
-------
K
----
A
GV
E
-
H
Q
-----
L
R
R
---
E
-----
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
-
Y
G
----
Y
F
H
D
------
A
-
T
R
V
-
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
-
Q
K
L
-
S
----
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
--------
E
L
K
I
A
D
F
G
W
S
V
-
H
A
P
-
S
-
S
----
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
------
G
---
R
--
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
-----
Y
Q
-
E
-
T
---------------
Y
K
-------------------
R
----
I
S
----
R
-
V
-
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
52.36
33%
-7
- C2 -
-
5AUU
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
---
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
52.35
33%
-9
- C2 -
-
5AV0
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
52.34
33%
-6
- C2 -
-
5AUZ
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
---
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
52.31
33%
-8
- C2 -
-
5AV4
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
---
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
52.14
34%
-123
- C2 -
-
5TX3
2
MELK_HUMAN
B:
[19-267]
--------------------------
E
-
T
I
G
-----
K
V
K
L
A
C
H
I
L
T
G
E
M
-
V
A
I
K
I
M
D
K
------------------------------
K
T
---
E
-----
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
-
Y
H
----
V
L
E
T
------
A
-
N
K
I
-
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
-
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
---------
K
L
K
L
I
D
-----------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
------
G
--------
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
-----
V
M
-
A
-
L
---------------
Y
K
-------------------
K
----
I
M
----
R
-
G
-
K
Y
--
D
V
P
--
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
----
S
M
K
N
L
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
52.08
33%
-9
- C2 -
-
5AV3
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
52.05
33%
-5
- C2 -
-
6FHB
2
DAPK1_HUMAN
A:
[22-278]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
52.01
33%
-7
- C2 -
-
5AUV
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
51.96
33%
-10
- C2 -
-
5AUW
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
----------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
51.95
33%
-8
- C2 -
-
5AV2
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
562
HHSearch
51.84
30%
-32
- C2 -
-
3C0I
1
CSKP_HUMAN
A:
[26-294]
----------------------
Y
E
L
C
E
-
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
-
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
SSPG---
L
----
S
--
T
-
E
D
-----
L
K
R
---
E
-----
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
-
L
E
----
T
Y
S
S
------
D
-
G
M
L
-
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
-
V
K
R
-
A
DAGF
V
---
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
------
N
S
A
P
V
K
L
G
G
F
G
V
A
I
-
Q
L
G
-
E
-
S
-
G
L-
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
---
E
--
P
Y
G
K
-
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-----
E
R
-
L
-
F
-----
E
G
I
-------
I
K
-------------------
G
----
K
Y
----
K
-
M
-
N
P
--
R
Q
W
--
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
51.78
33%
-9
- C2 -
-
4ZTR
1
AURKA_HUMAN
A:
[21-270]
-----------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
-
L
A
L
K
V
L
F
K
A
Q
L
-
E
-------
K
----
A
GV
E
-
H
Q
-----
L
R
R
---
E
-----
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
-
Y
G
----
Y
F
H
D
------
A
-
T
R
V
-
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
-
Q
K
L
-
S
----
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
--------
E
L
K
I
A
D
F
G
W
--------------------
G
T
L
D
Y
L
P
P
E
M
I
E
------
G
---
R
--
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
-----
Y
Q
-
E
-
T
---------------
Y
K
-------------------
R
----
I
S
----
R
-
V
-
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
51.76
33%
-7
- C2 -
-
4B4L
3
DAPK1_HUMAN
A:
[21-277]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
51.75
34%
-3
- C2 -
-
2XBJ
1
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
G
A
-
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------ALN--
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
----
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
51.66
33%
-4
- C2 -
-
5AUY
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
51.58
34%
-5
- C2 -
-
4BDB
10
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
------
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------LN---
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
--
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
51.54
33%
-5
- C2 -
-
5AUX
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
------
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
51.49
34%
-22
- C2 -
-
4BDA
8
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
----
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
--
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
51.39
36%
-128
- C2 -
-
5JZJ
1
B:
[44-273]
-----------------------------
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
-
E
Y
A
L
K
I
I
K
K
S
K
C
-
R
-------
G
----
K
--
E
-
H
M
-----
I
Q
N
---
E
-----
V
S
I
L
R
R
V
-
K
H
P
N
I
V
L
L
-
I
E
----
E
M
D
V
------
P
-
T
E
L
-
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
-
T
S
T
-
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
-----
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
T
-
I
V
D
-
G
-
P
-
L
--
Y
--
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
------
E
---
T
--
G
Y
G
L
-
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
S
G
-----
D
D
-
Q
-
E
-----
V
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
51.36
33%
-4
- C2 -
-
2W4K
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
51.23
31%
-107
- C2 -
-
4FG9
1
KCC1A_HUMAN
A:
[23-285]
-------------------------
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
-
V
A
I
K
C
I
A
K
E
-----------------------------
E
N
---
E
-----
I
A
V
L
H
K
I
-
K
H
P
N
I
V
A
L
-
D
D
----
I
Y
E
S
------
G
-
G
H
L
-
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
-
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-----
L
D
E
D
S
-
K
I
M
I
S
D
F
------------------------
P
G
Y
V
A
P
E
V
L
A
------
Q
---
K
--
P
Y
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
--------
D
-
A
-----
K
L
F
EQILKAE
Y
E
-------------------
F
----
D
S
----
P
-
Y
-
W
D
--
D
I
------
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
51.21
33%
-3
- C2 -
-
1WVY
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
51.14
36%
-27
- C2 -
-
5EAK
1
MARK2_HUMAN
B:
[23-287]
-----------------------------
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
-------
S
----
S
--
L
-
Q
K
-----
L
F
R
---
E
-----
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
-
F
E
----
V
I
E
T
------
E
-
K
T
L
-
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
-
G
----
R
---
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---------
A
D
M
N
I
K
I
A
D
F
G
-------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
------
G
---
K
--
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
-----
L
K
-
E
-
L
-----
R
E
R
-------
V
L
-------------------
R
----
G
K
----
Y
-------
R
I
P
--
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
VE
P
L
P
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
560
HHSearch
51.08
30%
-17
- C2 -
-
4B99
1
MK07_HUMAN
A:
[56-352]
----------------------
Y
E
I
I
E
-
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
-
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
-
V
V------
T
----
N
--
A
-
K
R
-----
T
L
R
---
E
-----
L
K
I
L
K
H
F
-
K
H
D
N
I
I
A
I
-
K
D
----
I
L
R
P
TVPYGE
F
-
K
S
V
-
Y
V
V
L
D
L
M
E
-
S
D
L
H
Q
I
I
-
H
S
S
-
Q
----
P
---
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
---------
C
E
L
K
I
G
D
F
G
M
A
R
-
G
L
-------QY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
------
S
L--
H
--
E
Y
T
Q
-
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
-----
Y
V
-
H
-
Q
-----
L
Q
L
-------
I
M
MVLGTPSPAVIQRVRAYIQ
S
LPPR
Q
P
----
V
-
P
-
W
E
--
T
V
Y
--
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
----
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
50.98
33%
-6
- C2 -
-
3LAU
1
AURKA_HUMAN
A:
[16-265]
-----------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
-
L
A
L
K
V
L
F
K
A
Q
L
-
E
-------
K
----
A
GV
E
-
H
Q
-----
L
R
R
---
E
-----
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
-
Y
G
----
Y
F
H
D
------
A
-
T
R
V
-
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
-
Q
K
L
-
S
----
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
--------
E
L
K
I
A
D
F
------------------------
L
D
Y
L
P
P
E
M
I
E
------
G
---
R
--
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
-----
Y
Q
-
E
-
T
---------------
Y
K
-------------------
R
----
I
S
----
R
-
V
-
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
50.93
33%
18
- C2 -
-
4TXC
7
DAPK1_HUMAN
A:
[21-294]
---------
T
V
F
R
Q
--
E
NVDDY
Y
D
T
G
E
-
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
50.92
32%
-31
- C2 -
-
2WEI
1
?
A:
[29-285]
----------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
-
E
Y
A
V
K
V
I
N
K
A
S
A
-
K
N------
K
----
D
--
T
-
S
T
-----
I
L
R
---
E
-----
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
-
F
E
----
I
L
E
D
------
S
-
S
S
F
-
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
-
I
K
R
-
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
------
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
-
Q
-
N
-
T
--
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
------
G
---
T
---
Y
D
E
-
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
-----
E
Y
-
D
-
I
-----
L
K
R
-------
V
E
-------------------
T
----
G
K
----
Y
-
A
-
F
---
D
L
P
QW
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
----
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
50.84
34%
-7
- C2 -
-
4BDE
5
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
------
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------ALN--
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
----
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
50.81
33%
-1
- C2 -
-
6QMO
7
DAPK1_HUMAN
A:
[22-278]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
50.80
36%
-16
- C2 -
-
5KZ8
1
MARK2_HUMAN
B:
[41-305]
-----------------------------
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
-------
S
----
S
--
L
-
Q
K
-----
L
F
R
---
E
-----
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
-
F
E
----
V
I
E
T
------
E
-
K
T
L
-
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
-
G
----
R
---
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---------
A
D
M
N
I
K
I
A
D
F
----------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
------
G
---
K
--
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
-----
L
K
-
E
-
L
-----
R
E
R
-------
V
L
-------------------
R
----
G
K
----
Y
-------
R
I
P
--
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
VE
P
L
P
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
50.71
33%
-11
- C2 -
-
2XUU
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
50.61
34%
12
- C2 -
-
4A9S
1
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
------
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------PALN-
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
----
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
50.56
33%
-3
- C2 -
-
2YAK
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
50.53
34%
10
- C2 -
-
4A9U
10
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
----
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------DPALN
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
----
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
50.35
34%
-30
- C2 -
-
2CN8
1
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
----
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
----
T
-
S
--
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
--------V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
50.07
34%
10
- C2 -
-
2WTJ
5
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
----
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------PALN-
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
--
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
49.86
34%
12
- C2 -
-
2WTD
4
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
----
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------PALN-
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
----
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
49.86
33%
-4
- C2 -
-
2Y0A
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
49.80
34%
18
- C2 -
-
4A9T
4
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
---
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------PALN-
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
49.75
36%
-127
- C2 -
-
5JZN
1
B:
[27-229]
-----------------------------
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
-
E
Y
A
L
K
I
I
K
K
S
K
C
-
R
-------
G
----
K
--
E
-
H
M
-----
I
Q
N
---
E
-----
V
S
I
L
R
R
V
-
K
H
P
N
I
V
L
L
-
I
E
----
E
M
D
V
------
P
-
T
E
L
-
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
-
T
S
T
-
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
-----
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
T
-
I
V
D
-
G
-
P
-
L
--
Y
--
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
------
E
---
T
--
G
Y
G
L
-
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
S
---------
Q
-
E
-----
V
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
49.75
34%
19
- C2 -
-
4A9R
2
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
------
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------PALN-
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
49.54
35%
-17
- C2 -
-
5KZ7
1
MARK2_HUMAN
A:
[41-305]
-----------------------------
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
-------
S
----
S
--
L
-
Q
K
-----
L
F
R
---
E
-----
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
-
F
E
----
V
I
E
T
------
E
-
K
T
L
-
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
-
G
----
R
---
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---------
A
D
M
N
I
K
I
A
D
F
----------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
------
G
---
K
----
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
-----
L
K
-
E
-
L
-----
R
E
R
-------
V
L
-------------------
R
----
G
K
----
Y
-------
R
I
P
--
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
VE
P
L
P
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
49.45
36%
-12
- C2 -
-
5KZ7
1
MARK2_HUMAN
B:
[41-305]
-----------------------------
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
-
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
-------
S
----
S
--
L
-
Q
K
-----
L
F
R
---
E
-----
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
-
F
E
----
V
I
E
T
------
E
-
K
T
L
-
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
-
G
----
R
---
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---------
A
D
M
N
I
K
I
A
D
F
----------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
------
G
---
K
----
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
-----
L
K
-
E
-
L
-----
R
E
R
-------
V
L
-------------------
R
----
G
K
----
Y
-------
R
I
P
--
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
----
T
L
E
Q
I
M
K
D
R
W
M
N
V
G
H
E
D
D
E
L
K
P
Y
VE
P
L
P
D
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
49.44
34%
-2
- C2 -
-
4BDK
4
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
----
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------ALN--
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
49.18
33%
-10
- C2 -
-
5L8K
9
AURKA_HUMAN
A:
[21-270]
-----------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
-
L
A
L
K
V
L
F
K
A
Q
L
-
E
-------
K
----
A
GV
E
-
H
Q
-----
L
R
R
---
E
-----
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
-
Y
G
----
Y
F
H
D
------
A
-
T
R
V
-
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
-
Q
K
L
-
S
----
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
--------
E
L
K
I
A
D
F
G
W
S
V
-
H
A
P
-
S
-
S
-----
R
R
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
E
------
G
---
R
--
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
-----
Y
Q
-
E
-
T
---------------
Y
K
-------------------
R
----
I
S
----
R
-
V
-
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
48.99
34%
16
- C2 -
-
2XM9
1
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
---
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------PALN-
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
G
-
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
48.94
36%
-127
- C2 -
-
5JZN
1
DCLK1_HUMAN
A:
[27-229]
-----------------------------
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
-
E
Y
A
L
K
I
I
K
K
S
K
C
-
R
-------
G
----
K
--
E
-
H
M
-----
I
Q
N
---
E
-----
V
S
I
L
R
R
V
-
K
H
P
N
I
V
L
L
-
I
E
----
E
M
D
V
------
P
-
T
E
L
-
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
-
T
S
T
-
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
-----
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
T
-
I
V
D
-
G
-
P
-
L
--
Y
--
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
------
E
---
T
--
G
Y
G
L
-
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
S
-------
D
-
Q
-
E
-----
V
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
48.80
37%
-51
- C2 -
-
5ES1
1
MARK4_HUMAN
A:
[14-250]
----------
V
G
N
Y
--
R
-----
L
L
R
T
---
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
-
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
-
N
-------
P
----
S
--
S
L
Q
K
-----
L
F
R
---
E
-----
V
R
I
M
K
G
L
-
N
H
P
N
I
V
K
L
-
F
E
----
V
I
E
T
------
E
-
K
T
L
-
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
-
V
S
H
-
G
----
R
---
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
E
A
---------
N
I
K
I
A
D
F
G
F
S
N
-------------------
S
P
P
Y
A
A
P
E
L
F
Q
------
G
---
K
--
K
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
H
N
-----
L
K
-
E
-
L
-----
R
E
R
-------
V
L
-------------------
R
----
G
K
----
Y
-
R
-
V
P
F-
Y
M
S
--
T
D
C
E
S
I
L
R
R
F
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
48.77
34%
-25
- C2 -
-
5XZV
1
RAD53_YEAST
A:
[196-465]
----------------
D
-----
F
S
I
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
-
T
F
A
V
K
I
I
S
K
R
K
V
-
I
-------
G
----
N
--
M
-
D
G
-----
V
T
R
---
E
-----
L
E
V
L
Q
K
L
-
N
H
P
R
I
V
R
L
-
K
G
----
F
Y
E
D
------
T
-
E
S
Y
-
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
-
A
A
H
-
G
----
A
---
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
-----
E
Q
D
D
P
--
V
L
V
K
I
T
D
F
G
L
A
K
--------------------
L
A
Y
V
A
P
E
V
I
------------N-
E
Y
S
S
-
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
--
S
T
-----
Q
D
-
Q
-
L
YKQIG
R
G
S
-----------------------------------------------
L
K
D
--
F
R
I
S
E
E
A
R
D
F
I
D
S
L
---
D
P
N
N
------
T
A
A
K
A
L
N
H
P
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
48.73
34%
15
- C2 -
-
5VJA
3
DAPK3_HUMAN
D:
[13-271]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
-
E
Y
A
A
K
F
I
K
K
R
R
L
-
S
------------------------
V
S
R
---
E
EIERE
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
----
E
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
------
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
T
L
-----
T
N
I
-------
S
A
-------------------
V
----
N
Y
----
D
-
F
-
D
E
--
E
Y
F
--
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
S
L
E
H
S
W
I
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
48.56
34%
17
- C2 -
-
2WTI
3
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
----
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------PALN-
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
--
E
-
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
48.54
33%
5
- C2 -
-
6AAR
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
----------------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
48.51
33%
-29
- C2 -
-
2GNH
2
KAPCA_BOVIN
A:
[42-280]
----------------
Q
-----
F
E
R
I
K
-
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
K
V
A
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
48.48
33%
-21
- C2 -
-
2GNI
1
KAPCA_BOVIN
A:
[42-280]
----------------
Q
-----
F
E
R
I
K
-
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
K
V
A
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
48.32
36%
-134
- C2 -
-
5JZJ
2
DCLK1_HUMAN
A:
[44-246]
-----------------------------
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
-
E
Y
A
L
K
I
I
K
K
S
K
C
-
R
-------
G
----
K
--
E
-
H
M
-----
I
Q
N
---
E
-----
V
S
I
L
R
R
V
-
K
H
P
N
I
V
L
L
-
I
E
----
E
M
D
V
------
P
-
T
E
L
-
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
-
T
S
T
-
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
-----
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
T
-
I
V
D
-
G
-
P
-
L
--
Y
--
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
------
E
---
T
--
G
Y
G
L
-
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
S
-----------
E
-----
V
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
48.07
34%
-39
- C2 -
-
3COK
1
PLK4_HUMAN
A:
[12-267]
----------------
D
-----
F
K
V
G
N
-
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
-
G
L
E
V
A
I
K
M
I
D
K
K
A
M
-
Y
-------
K
----
A
--
G
-
M
V
QR---
V
Q
N
---
E
-----
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
-
Y
N
----
Y
F
E
D
------
S
-
N
Y
V
-
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
-
K
----
P
---
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
---------
N
M
N
I
K
I
A
D
F
G
L
A
T
-
Q
L
K
--------------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
-----
V
-----------------------------------------------
K
----
V
-
V
-
L
A
DY
E
M
P
--
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
----
S
L
S
S
V
L
D
H
P
F
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
48.02
34%
19
- C2 -
-
2WTC
1
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
G
S
----
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------------PALN-
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
----
T
-
S
--
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
47.73
33%
-25
- C2 -
-
2GNF
1
KAPCA_BOVIN
A:
[42-280]
----------------
Q
-----
F
E
R
I
K
-
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
K
V
A
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
47.65
34%
-22
- C2 -
-
2XM8
1
CHK2_HUMAN
A:
[17-292]
----------------
E
-----
Y
I
M
S
K
-
T
L
-----
G
E
V
-
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---------------------------N----
V
E
T
---
E
-----
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
----
F
F
D
-------
A
-
E
D
Y
-
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
-
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
------
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
-
I
L
----
T
-
S
--
L
M
R
T
L
C
G
---
Y
L
A
P
E
V
L
V
------
S
VGT
A
--
G
Y
N
R
-
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
-----
T
Q
V
S
-
L
-----
K
D
Q
-------
I
T
-------------------
S
----
G
K
Y---
N
-
F
-
I
P
--
E
V
W
--
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
----
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
47.61
34%
11
- C2 -
-
5VJA
2
DAPK3_HUMAN
A:
[13-271]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
-
E
Y
A
A
K
F
I
K
K
R
-------------------
R
-
R
G
-----
V
S
R
---
E
EIERE
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
K
N
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
T
L
-----
T
N
I
-------
S
A
-------------------
V
----
N
Y
----
D
-
F
-
D
E
--
E
Y
F
--
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
S
L
E
H
S
W
I
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
47.52
34%
8
- C2 -
-
5VJA
2
DAPK3_HUMAN
B:
[13-271]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
-
E
Y
A
A
K
F
I
K
K
--------------------
R
-
R
G
-----
V
S
R
---
E
EIERE
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
K
N
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
T
L
-----
T
N
I
-------
S
A
-------------------
V
----
N
Y
----
D
-
F
-
D
E
--
E
Y
F
--
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
S
L
E
H
S
W
I
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
47.45
32%
-27
- C2 -
-
1BKX
1
KAPCA_MOUSE
A:
[42-280]
----------------
Q
-----
F
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
HHSearch
47.44
31%
3
- C2 -
-
2Y7J
1
PHKG2_HUMAN
A:
[96-364]
----------------------
Y
D
P
K
D
-
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
-
G
H
E
F
A
V
K
I
M
E
V
T
A
E
-
R
LSPEQLE
E
----
V
--
R
-
E
A
-----
T
R
R
---
E
-----
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
-
I
D
----
S
Y
E
S
------
S
-
S
F
M
-
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
-
T
E
K
-
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
---------
M
Q
I
R
L
S
D
F
G
F
S
C
-
H
L
E
-
P
-
G
-
E
--
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
---
P
--
G
Y
G
K
-
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
-----
Q
I
-
L
-
M
-----
L
R
M
-------
I
M
-------------------
E
----
G
Q
----
Y
-
Q
F
S
S
--
P
E
W
--
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
47.31
34%
1
- C2 -
-
3BHY
1
DAPK3_HUMAN
A:
[13-271]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
-
E
Y
A
A
K
F
I
K
K
R
R
L
-
S
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
EIERE
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
K
N
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-------------
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
T
L
-----
T
N
I
-------
S
A
-------------------
V
----
N
Y
----
D
-
F
-
D
E
--
E
Y
F
--
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
S
L
E
H
S
W
I
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
47.24
33%
-25
- C2 -
-
2GNJ
1
KAPCA_BOVIN
A:
[42-280]
----------------
Q
-----
F
E
R
I
K
-
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
K
V
A
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
47.15
33%
-58
- C2 -
-
6BX6
1
AAPK2_HUMAN
A:
[10-265]
----------
I
G
H
Y
--
V
-----
L
G
--
D
-
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
-
K
V
A
V
K
I
L
N
R
Q
K
I
---------
R
----
S
--
L
-
D
V
-----
V
G
K
IKR
E
-----
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
-
Y
Q
----
V
I
S
T
------
P
-
T
D
F
-
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
H
-
G
----
R
---
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
------
A
H
M
N
A
---
K
I
A
D
F
G
L
S
----------------------
N
Y
A
A
P
E
-----------------
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
---
D
-----
D
E
-
H
-
V
-----
P
T
L
-------
F
K
-------------------
K
----
I
R
----
G
-
G
-
V
F
--
Y
I
P
--
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
----
T
I
K
D
I
R
E
H
E
W
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
HHSearch
47.09
30%
-41
- C2 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-350]
-------------
Y
--
T
-----
V
S
K
T
E
-
I
L
-----
G
Q
V
H
K
C
E
E
T
A
T
-
G
L
K
L
A
A
K
I
I
K
T
R
G
M
-
K
------------
D
--
K
-
E
E
-----
V
K
N
---
E
-----
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
-
Y
D
----
A
F
E
S
------
K
-
N
D
I
-
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
-
I
D
E
S
Y
----
N
---
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
-------
D
A
K
Q
I
K
I
I
D
F
G
L
A
R
-
R
Y
K
-
P
-
R
-
E
--
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
---
D
--
F
V
S
F
-
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
-----
D
A
-
E
-
T
-----
L
N
N
-------
I
L
-------------------
A
----
C
R
----
W
D
L
-
E
D
--
E
E
F
--
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
----
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
46.89
32%
-18
- C2 -
-
4NTT
1
KAPCA_MOUSE
A:
[42-280]
----------------
Q
-----
F
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
46.75
32%
-24
- C2 -
-
6MM8
5
KAPCA_MOUSE
C:
[31-280]
----------------
Q
-----
F
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
46.68
33%
-19
- C2 -
-
3ZXT
1
DAPK1_HUMAN
D:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
-------------------------------
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
---------------
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
46.68
34%
10
- C2 -
-
5VJA
2
DAPK3_HUMAN
C:
[13-271]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
-
E
Y
A
A
K
F
I
K
K
R
R
L
-
S
-------
S
----------
G
-----
V
S
R
---
E
EIERE
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
---
E
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
------
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
T
L
-----
T
N
I
-------
S
A
-------------------
V
----
N
Y
----
D
-
F
-
D
E
--
E
Y
F
--
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
S
L
E
H
S
W
I
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
46.62
33%
-27
- C2 -
-
2GNL
1
KAPCA_BOVIN
A:
[42-280]
----------------
Q
-----
F
E
R
I
K
-
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
K
V
A
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
46.61
32%
-18
- C2 -
-
6MM5
1
KAPCA_MOUSE
E:
[31-269]
----------------
Q
-----
F
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
46.58
32%
-23
- C2 -
-
6MM7
9
KAPCA_MOUSE
D:
[31-281]
----------------
Q
-----
F
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
46.35
32%
-21
- C2 -
-
3OVV
2
KAPCA_HUMAN
A:
[43-281]
----------------
Q
-----
F
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
46.31
34%
-15
- C2 -
-
5XZV
1
?
B:
[196-466]
----------------
D
-----
F
S
I
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
-
T
F
A
V
K
I
I
S
K
R
K
------------------
M
-
D
G
-----
V
T
R
---
E
-----
L
E
V
L
Q
K
L
-
N
H
P
R
I
V
R
L
-
K
G
----
F
Y
E
D
------
T
-
E
S
Y
-
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
-
A
A
H
-
G
----
A
---
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
-----
E
Q
D
D
P
--
V
L
V
K
I
T
D
F
G
L
-----------------
T
F
C
G
T
L
A
Y
V
A
P
E
V
I
------------RN
E
Y
S
S
-
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
S
T
-----
Q
D
-
Q
-
L
YKQIG
R
G
S
-------
Y
H
-------------------
E
----
G
----------
P
--
L
K
D
--
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
----
T
A
A
K
A
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
46.24
34%
1
- C2 -
-
5A6O
2
DAPK3_HUMAN
B:
[13-271]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
-
E
Y
A
A
K
F
I
K
K
R
R
L
-
S
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
EIERE
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
K
N
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
----------
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
T
L
-----
T
N
I
-------
S
A
-------------------
V
----
N
Y
----
D
-
F
-
D
E
--
E
Y
F
--
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
S
L
E
H
S
W
I
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
46.02
32%
-23
- C2 -
-
3POO
2
KAPCA_HUMAN
A:
[43-285]
----------------
Q
-----
F
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
45.90
34%
-28
- C2 -
-
4JXF
2
PLK4_HUMAN
A:
[8-262]
----------------
D
-----
F
K
V
G
N
-
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
-
G
L
E
V
A
I
K
M
I
D
K
K
A
M
-
Y
-------
K
----
A
--
G
-
M
V
QR---
V
Q
N
---
E
-----
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
-
Y
N
----
Y
F
E
D
------
S
-
N
Y
V
-
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
-
K
----
P
---
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
---------
N
M
N
I
K
I
A
D
F
G
L
A
T
-
Q
L
K
M
P
-
H
----------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---------
V
K
-
N
------------------
T
-------------------
L
----
N
K
----
V
-
V
-
L
A
DY
E
M
P
--
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
----
S
L
S
S
V
L
D
H
P
F
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
45.77
33%
-5
- C2 -
-
2WTV
3
AURKA_HUMAN
C:
[21-270]
-----------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
-
L
A
L
K
V
L
F
K
A
Q
L
-
E
-------
K
----
A
GV
E
-
H
Q
-----
L
R
R
---
E
-----
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
-
Y
G
----
Y
F
H
D
------
A
-
T
R
V
-
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
-
Q
K
L
-
S
----
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
--------
E
L
K
I
A
D
F
G
W
S
V
-
H
A
P
-
S
-
S
-
R
--
R
L
G
T
L
D
----
Y
L
P
P
E
M
I
E
------
G
---
R
--
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
-----
Y
Q
-
E
-
T
---------------
Y
K
-------------------
R
----
I
S
----
R
-
V
-
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
45.69
32%
-21
- C2 -
-
4UJ2
2
KAPCA_HUMAN
A:
[43-281]
----------------
Q
-----
F
E
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
45.32
34%
0
- C2 -
-
5A6N
1
DAPK3_HUMAN
B:
[13-271]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
-
E
Y
A
A
K
F
I
K
K
R
R
L
-
S
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
EIERE
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
K
N
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
----------
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
T
L
-----
T
N
I
-------
S
A
-------------------
V
----
N
Y
----
D
-
F
-
D
E
--
E
Y
F
--
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
S
L
E
H
S
W
I
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
45.21
34%
-4
- C2 -
-
5A6O
3
DAPK3_HUMAN
A:
[13-271]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
-
E
Y
A
A
K
F
I
K
K
R
R
L
-
S
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
EIERE
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
K
N
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
----------
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
T
L
-----
T
N
I
-------
S
A
-------------------
V
----
N
Y
----
D
-
F
-
D
E
--
E
Y
F
--
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
S
L
E
H
S
W
I
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
44.85
32%
-22
- C2 -
-
6MM6
1
KAPCA_MOUSE
E:
[31-282]
----------------
Q
-----
F
D
R
I
K
-
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
-
H
Y
A
M
K
I
L
D
K
Q
K
V
-
V
-------
K
LKQI
E
--
H
-
T
L
-------
N
---
E
-----
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
----
F
K
D
N
------
S
-
N
-
L
-
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
R
I
-
G
----
R
---
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
---------
Y
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-
T
--
W
T
--
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
------
S
---
K
--
G
Y
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
-----
P
I
-
Q
-
I
---------------
Y
E
-------------------
K
----
I
V
----
S
-
G
-
K
V
--
R
F
P
--
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
44.30
34%
7
- C2 -
-
3BQR
4
DAPK3_HUMAN
A:
[13-271]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
-
E
Y
A
A
K
F
I
K
K
R
R
L
-
S
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
EIERE
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
K
N
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
-
N
-----
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
T
L
-----
T
N
I
-------
S
A
-------------------
V
----
N
Y
----
D
-
F
-
D
E
--
E
Y
F
--
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
----
T
I
A
Q
S
L
E
H
S
W
I
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
43.21
33%
-7
- C2 -
-
3ZXT
1
DAPK1_HUMAN
A:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
----------------------------
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
-
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-----------------
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
43.12
33%
0
- C2 -
-
4YUR
1
PLK4_HUMAN
A:
[8-269]
----------
I
G
E
K
IE
D
-----
F
K
V
G
N
-
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
-
G
L
E
V
A
I
K
M
I
D
K
K
A
M
-
Y
-------
K
----
A
--
G
-
M
V
QR---
V
Q
N
---
E
-----
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
-
Y
N
----
Y
F
E
D
------
S
-
N
Y
V
-
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
-
K
----
P
---
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
---------
N
M
N
I
K
I
A
D
F
-------------------------------------------------
G
L
-
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---
T
-----
V
K
-
N
------------------
T
-------------------
L
----
N
K
----
V
-
V
-
L
A
DY
E
M
P
--
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
----
S
L
S
S
V
L
D
H
P
F
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
43.05
38%
-64
- C2 -
-
4JG8
1
A:
[37-239]
----------------------
Y
E
V
K
E
-
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
-
N
M
E
F
A
V
K
I
I
D
K
S
K
R
-
D
-------
P
----
T
--
E
--------------
E
-----
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
-
K
D
----
V
Y
D
D
------
G
-
K
Y
V
-
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
K
I
-
L
R
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---
N
P
E
S
I
R
--
I
C
D
F
G
F
A
K
-
Q
L
R
-
A
E
N
-
G
--
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
---
Q
--
G
Y
D
A
-
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
G
-----
P
D
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
42.22
38%
-61
- C2 -
-
4MAO
1
A:
[37-239]
----------------------
Y
E
V
K
E
-
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
-
N
M
E
F
A
V
K
I
I
D
K
S
K
R
-
D
-------
P
----
T
--
E
--------------
E
-----
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
-
K
D
----
V
Y
D
D
------
G
-
K
Y
V
-
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
K
I
-
L
R
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---
N
P
E
S
I
R
--
I
C
D
F
G
F
A
K
-
Q
L
R
-
A
E
N
-
G
--
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
---
Q
--
G
Y
D
A
-
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
G
-----
P
D
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
41.94
38%
-63
- C2 -
-
4D9U
1
A:
[24-226]
----------------------
Y
E
V
K
E
-
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
-
N
M
E
F
A
V
K
I
I
D
K
S
K
R
-
D
-------
P
----
T
--
E
--------------
E
-----
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
-
K
D
----
V
Y
D
D
------
G
-
K
Y
V
-
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
-
L
R
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---
N
P
E
S
I
R
--
I
C
D
F
G
F
A
K
-
Q
L
R
-
A
E
N
-
G
--
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
---
Q
--
G
Y
D
A
-
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
G
-----
P
D
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
41.28
38%
-54
- C2 -
-
4D9T
1
A:
[24-226]
----------------------
Y
E
V
K
E
-
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
-
N
M
E
F
A
V
K
I
I
D
K
S
K
R
-
D
-------
P
----
T
--
E
--------------
E
-----
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
-
K
D
----
V
Y
D
D
------
G
-
K
Y
V
-
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
-
L
R
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---
N
P
E
S
I
R
--
I
C
D
F
G
F
A
K
-
Q
L
R
-
A
E
N
-
G
--
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
---
Q
--
G
Y
D
A
-
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
G
-----
P
D
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
41.20
38%
-59
- C2 -
-
4M8T
1
A:
[37-239]
----------------------
Y
E
V
K
E
-
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
-
N
M
E
F
A
V
K
I
I
D
K
S
K
R
-
D
-------
P
----
T
--
E
--------------
E
-----
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
-
K
D
----
V
Y
D
D
------
G
-
K
Y
V
-
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
K
I
-
L
R
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---
N
P
E
S
I
R
--
I
C
D
F
G
F
A
K
-
Q
L
R
-
A
E
N
-
G
--
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
---
Q
--
G
Y
D
A
-
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
G
-----
P
D
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
41.00
37%
-29
- C2 -
-
4REW
1
AAPK1_HUMAN
A:
[1-335]
------
G
S
V
K
I
G
H
Y
--
I
-----
L
G
--
D
-
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
-
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
---------
R
----
S
--
L
-
D
V
-----
V
G
K
IRR
E
-----
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
-
Y
Q
----
V
I
S
T
------
P
-
S
D
I
-
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
-
G
----
R
---
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
------
A
H
M
N
A
---
K
I
A
D
F
G
L
S
N
-
M
M
S
-
D
-
G
-
E
--
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
------
G
---
R
--
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
40.95
38%
-60
- C2 -
-
4JG7
1
A:
[37-239]
----------------------
Y
E
V
K
E
-
D
I
G
V
--
Y
S
V
C
K
R
C
I
H
K
A
T
-
N
M
E
F
A
V
K
I
I
D
K
S
K
R
-
D
-------
P
----
T
--
E
--------------
E
-----
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
-
K
D
----
V
Y
D
D
------
G
-
K
Y
V
-
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
-
L
R
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---
N
P
E
S
I
R
--
I
C
D
F
G
F
A
K
-
Q
L
R
-
A
E
N
-
G
--
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
---
Q
--
G
Y
D
A
-
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
G
-----
P
D
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
39.32
33%
-10
- C2 -
-
3ZXT
1
DAPK1_HUMAN
B:
[19-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
------------
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
----------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
---------------
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
-----
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
39.23
38%
-67
- C2 -
-
4JG6
1
A:
[37-239]
----------------------
Y
E
V
K
E
-
D
I
-----
S
V
C
K
R
C
I
H
K
A
T
-
N
M
E
F
A
V
K
I
I
D
K
S
K
R
-
D
-------
P
----
T
--
E
--------------
E
-----
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
-
K
D
----
V
Y
D
D
------
G
-
K
Y
V
-
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
-
L
R
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---
N
P
E
S
I
R
--
I
C
D
F
G
F
A
K
-
Q
L
R
-
A
E
N
-
G
--
L
L
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
------
R
---
Q
--
G
Y
D
A
-
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
G
-----
P
D
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
37.18
38%
-60
- C2 -
-
5O1S
2
A:
[46-248]
----------------------
Y
E
V
K
E
-
D
I
-----
S
V
C
K
R
C
I
H
K
A
T
-
N
M
E
F
A
V
K
I
I
D
K
S
K
R
-
D
-------
P
----
T
--
E
--------------
E
-----
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
-
K
D
----
V
Y
D
D
------
G
-
K
Y
V
-
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
-
L
R
Q
-
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---
N
P
E
S
I
R
--
I
C
D
F
G
F
A
K
-
Q
L
R
-
A
E
N
-
G
--
L
L
M
T
P
C
---
N
F
V
A
P
E
V
L
E
------
R
---
Q
--
G
Y
D
A
-
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
-
A
N
G
-----
P
D
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
36.34
36%
-31
- C2 -
-
3RZF
1
?
A:
[18-305]
----------------
E
-----
M
--
K
E
-
R
L
G
T
G
G
F
G
Y
V
L
R
W
I
H
Q
D
T
G
E
-
Q
V
A
I
K
Q
C
R
Q
E
L
S
-
P
-------
K
----
N
--
R
-
E
R
-----
W
C
L
---
E
-----
I
Q
I
M
K
K
L
-
N
H
P
N
V
V
S
A
-
R
E
VPDG
L
Q
K
L
------
A
P
N
D
L
P
L
L
A
M
E
Y
C
E
G
G
D
L
R
K
Y
L
-
N
Q
F
-
E
----
N
CCG
L
K
E
G
P
I
R
T
L
L
S
D
I
S
S
A
L
R
Y
L
H
E
N
R
I
I
H
R
D
L
K
P
E
N
I
V
L
------
Q
P
G
P
Q
R
L
I
H
K
I
I
D
L
G
Y
A
K
-
E
L
D
-
Q
-
G
-
E
--
L
C
T
E
F
V
G
T
L
Q
Y
L
A
P
E
L
L
E
------
Q
---
K
--
K
Y
T
V
-
T
V
D
Y
W
S
F
G
T
L
A
F
E
C
I
T
G
F
R
P
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
36.13
37%
-56
- C2 -
-
2WNT
1
B:
[29-231]
----------------------
Y
V
V
K
E
-
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
-
N
M
E
Y
A
V
K
V
I
D
K
S
K
R
-
D
-------
P
----
S
--
E
--------------
E
-----
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
-
K
D
----
V
Y
D
D
------
G
-
K
H
V
-
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
-
L
R
Q
-
K
----
F
---
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
---
N
P
E
C
L
R
--
I
C
D
F
G
F
A
K
-
Q
L
R
-
A
E
N
-
G
--
L
L
M
T
P
C
Y
----------
K
------
R
---
Q
--
G
Y
D
E
-
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
-
A
N
G
-----
P
S
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
28.79
33%
4
- C2 -
-
3ZXT
1
DAPK1_HUMAN
C:
[15-275]
-----------------------------
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
-
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
-
K
-------
S
----
S
--
R
-
R
G
-----
V
S
R
---
E
DIERE
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
-
H
E
----
V
Y
E
N
------
K
-
T
D
V
-
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
R
N
V
P
K
P
-
R
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
--------------
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
-----
K
Q
-
E
T
L
-----
A
N
V
-------
S
A
-------------------
V
----
N
Y
----
E
-
F
-
E
D
--
E
Y
F
--
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
----
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
26.91
37%
-8
- C2 -
-
2J90
2
DAPK3_HUMAN
A:
[34-239]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
-
E
Y
A
A
K
F
I
K
K
R
R
L
-
S
-------
S
RRGV
S
--
R
-
E
E
-----
I
E
R
---
E
-----
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
-
A
E
K
-
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
K
N
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-------------
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
26.68
37%
-7
- C2 -
-
2J90
2
DAPK3_HUMAN
B:
[34-239]
-----------------------------
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
----
K
-
E
Y
A
A
K
F
I
K
K
R
R
L
-
S
-------
S
RRGV
S
--
R
-
E
E
-----
I
E
R
---
E
-----
V
N
I
L
R
E
I
-
R
H
P
N
I
I
T
L
-
H
D
----
I
F
E
N
------
K
-
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
-
A
E
K
-
E
--------
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
----
K
N
V
P
N
P
-
R
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
-
N
--
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
---
E
--
P
L
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
T
-----
K
Q
-
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------